A catgut implantation material for treating ascites and a preparation method thereof

Abstract

A catgut implant for treating ascites and a preparation method thereof belong to the technical field of catgut preparation. Raw materials are as follows in percentage by mass: 27-31% of Gansui Banxia extract, 25-28% of humectant, 27-31% of water, 0.5-0.8% of glycyrrhizic acid, 5-9% of polyacrylic acid sodium, 1.5-4% of carboxymethyl cellulose sodium, 0.9-2.5% of polyvinylpyrrolidone, 0.03-0.06% of disodium edetate, 0.2-1.3% of organic acid, 0.5-0.9% of filling agent and 0.2-2% of transdermal penetration enhancer. The catgut implant improves the production process of catgut, reduces the production cost of catgut, has good formability and adhesion, and prepares Gansui Banxia decoction for treating ascites into catgut implant with controllable quality.

Description

Technical Field

[0001] This application relates to the field of poultice preparation technology, and more specifically, to a poultice acupoint patch for treating ascites and its preparation method. Background Technology

[0002] Cataplasmata refers to a topical dosage form made by mixing a drug or herbal extract with a suitable hydrophilic matrix and then applying it to a backing material.

[0003] Ascites is the most common complication of decompensated cirrhosis, presenting in approximately 20% of cirrhosis patients at their first visit, with a two-year mortality rate of about 50%. Due to the presence of ascites, cirrhosis patients are more susceptible to other complications such as bacterial infections, electrolyte imbalances, kidney damage, and malnutrition. Effective control of ascites is a crucial aspect of cirrhosis treatment. Patients with mild to moderate cirrhosis and ascites who respond to sodium restriction and diuretic therapy have a better prognosis. However, 15%–20% of cirrhosis patients with ascites do not respond to high-dose diuretics and are classified as refractory ascites (RA), with a one-year mortality rate as high as 60%–70%.

[0004] Traditional Chinese medicine (TCM) treatment of ascites due to liver cirrhosis is a distinctive feature of Chinese medicine. TCM plays a vital role in combating liver fibrosis, promoting ascites resolution, and preventing ascites recurrence. The formula Gansui Banxia Tang (Euphorbia kansui and Pinellia ternata decoction) was first recorded in the *Synopsis of Prescriptions of the Golden Chamber*, where it was described as follows: "Three large pieces of Gansui, twelve pieces of Pinellia ternata, five pieces of Paeonia lactiflora, and one piece of roasted licorice root the size of a finger. Boil in two liters of water until half a liter remains. Remove the dregs, add half a liter of honey to the decoction, and boil until eight-tenths of a decoction remains. Take it all at once." Gansui Banxia Tang is a potent purgative, with the effects of purging water retention, reducing swelling, and dissipating nodules.

[0005] Currently, Gansui Banxia Decoction is mainly administered to patients as a decoction. However, oral administration of traditional Chinese medicine often leads to patient aversion, especially among those with difficulty eating, making administration difficult and affecting efficacy. Furthermore, some Chinese medicine components can cause liver and kidney damage when taken orally. Traditional Chinese medicine emphasizes treating internal diseases externally. Now, Gansui Banxia Decoction is being converted into a plaster form for application to the patient's skin. This plaster is a water-based plaster with a high drug-carrying capacity, helping the medicine to exert its full effect and exhibiting low skin irritation. This plaster is applied to the Shenque acupoint on the patient's abdomen to utilize the acupoint's function and ensure more thorough drug delivery. Summary of the Invention

[0006] This invention aims to overcome the difficulties of low patient compliance with traditional Chinese medicine oral preparations, low drug loading capacity and poor transdermal properties of traditional plasters, and to improve the skin irritation and clinical efficacy of traditional plasters. Therefore, the classic ancient formula Gansui Banxia Decoction is made into an extract and then transformed into a poultice dosage form.

[0007] To achieve the above objectives, the present invention adopts the following technical solution:

[0008] A type of acupoint patch for treating ascites contains the following raw materials by weight percentage: 27%–31% *Euphorbia kansui* and *Pinellia ternata* extract, 25%–28% moisturizer, 27%–31% water, 0.5%–0.8% aluminum hydroxyacetate, 5%–7% sodium polyacrylate, 1.5%–4% sodium carboxymethyl cellulose, 0.9%–2.5% polyvinylpyrrolidone, 0.03%–0.06% disodium edetate, 0.2%–1.3% organic acid, 0.5%–0.9% filler, and 0.2%–2% transdermal penetration enhancer.

[0009] The herbal extract is a concentrated extract of four herbs: Euphorbia kansui, Pinellia ternata, Paeonia lactiflora, and Glycyrrhiza uralensis (processed). The mass ratio of Euphorbia kansui: Pinellia ternata: Paeonia lactiflora: Glycyrrhiza uralensis (processed) is 3:12:5:1.

[0010] The moisturizer is one or both of glycerin and propylene glycol.

[0011] The sodium polyacrylate is one of NP700 and NP800.

[0012] The polyvinylpyrrolidone is one of PVP-K30 and PVP-K90.

[0013] The organic acid is one of citric acid and tartaric acid.

[0014] The filler is one of kaolin, micronized silica gel, and titanium dioxide.

[0015] The transdermal penetration enhancer is one of carbomer, water-soluble azone, and poloxamer.

[0016] A method for preparing a poultice acupoint patch for treating ascites includes the following steps:

[0017] S1: Weigh each raw medicinal material in the formula according to the mass ratio, soak in 75% ethanol for 2-4 hours, then use the heating reflux method to add 75% ethanol in a volume ten times the total weight of the medicinal materials, heat and reflux for 2-4 hours, filter, and obtain the alcohol extract of the medicinal materials.

[0018] Add ten times the amount of water to the filtered residue, heat and reflux at 90℃~100℃ for 2-4 hours, repeat twice, and filter after each extraction to obtain an aqueous extract of the medicinal material.

[0019] The alcoholic extract and the aqueous extract of the combined medicinal materials were concentrated under reduced pressure to obtain an extract.

[0020] S2: Dissolve polyvinylpyrrolidone, disodium edetate, organic acid and transdermal penetration enhancer in water to obtain phase A, which is then set aside.

[0021] S3: Add sodium polyacrylate, aluminum hydroxyl, sodium carboxymethyl cellulose and filler to the humectant, stir well to obtain phase B, and set aside;

[0022] S4: Mix the extract of Euphorbia kansui and Pinellia ternata, phase A and phase B, stir evenly with a hook stirrer, spread the paste into a shape, cut it, pack it into an aluminum-plastic composite bag, heat and seal it, and then place it at room temperature.

[0023] Furthermore, a poultice for treating ascites includes a non-woven fabric backing material, a semi-solid ointment coated on the non-woven fabric, and a release film covering the semi-solid ointment. The semi-solid ointment includes extracts of Euphorbia kansui and Pinellia ternata, and excipients constituting the matrix. The original medicinal materials in the formula include Euphorbia kansui, Pinellia ternata, Paeonia lactiflora, and Glycyrrhiza uralensis (processed), with a mass ratio of Euphorbia kansui: Pinellia ternata: Paeonia lactiflora: Glycyrrhiza uralensis (processed) = 3:12:5:1. The excipients constituting the matrix of the poultice include: phase A: polyvinylpyrrolidone, disodium edetate, organic acids, transdermal penetration enhancers, and water; and phase B: sodium polyacrylate, sodium carboxymethyl cellulose, aluminum hydroxide, fillers, and humectants.

[0024] The preferred mass ratio of raw materials and excipients for the poultice is: *Glycyrrhiza uralensis* and *Pinellia ternata* extract: humectant: water: aluminum hydroxypropyl ester: sodium polyacrylate: sodium carboxymethyl cellulose: polyvinylpyrrolidone: disodium edetate: organic acid: filler: transdermal penetration enhancer = 27-31: 25-28: 27-31: 0.5-0.8: 5-7: 1.5-4: 0.9-2.5: 0.03-0.06: 0.2-1.3: 0.5-0.9: 0.2-2. A more preferred mass ratio is: *Glycyrrhiza uralensis* and *Pinellia ternata* extract: glycerin: water: aluminum hydroxypropyl ester: NP700: sodium carboxymethyl cellulose: PVP-K30: disodium edetate: tartaric acid: kaolin: carbomer = 29.4: 27.5: 29.4: 0.6: 6.5: 3.0: 1.3: 0.04: 0.9: 0.6: 0.8. A method for preparing a poultice acupoint patch for treating ascites includes the following steps:

[0025] S1: Weigh each raw medicinal material in the formula according to the mass ratio, soak in 75% ethanol for 2 hours, then use the reflux method, adding ten times the total mass of 75% ethanol, and heat under reflux at 80℃ for 2 hours. Filter to obtain the ethanol extract of the medicinal materials. Add ten times the volume of water to the filtered residue, and heat under reflux at 90℃~100℃ for 2 hours. Repeat this process twice, filtering after each extraction to obtain the water extract of the medicinal materials. Combine all filtrates and concentrate under reduced pressure to obtain the extract.

[0026] S2: Dissolve and mix. Weigh out the prescribed amounts of polyvinylpyrrolidone, disodium edetate, organic acid, and transdermal penetration enhancer, and dissolve them in the prescribed amount of water to obtain phase A, which is then set aside.

[0027] S3: Stir and mix, weigh out sodium polyacrylate, aluminum hydroxyl, sodium carboxymethyl cellulose and filler and add to the prescribed amount of humectant, stir evenly, until no obvious particles are visible to the naked eye, to obtain phase B, for later use;

[0028] S4: Mix the extract of Euphorbia kansui and Pinellia ternata, phase A and phase B, stir evenly with a hook stirrer, spread the paste into a shape, cut it, pack it into an aluminum-plastic composite bag, heat and seal it, and then place it at room temperature.

[0029] Step S2 requires the mixture to stand and dissolve overnight.

[0030] The stirring speed in step S3 is 80 r / min to 100 r / min, and the stirring time is 20 to 30 min.

[0031] The coating speed in step S4 is 600mm / min to 900mm / min, the coating thickness is 1mm to 2mm, and the coating is cut into a rectangle of 10cm×12cm.

[0032] The beneficial effects of this invention are:

[0033] 1) This invention utilizes the advantages of poultices, such as high drug loading capacity, good transdermal absorption, and low skin irritation. The Gansui and Banxia poultice for treating ascites prepared by this invention follows a classic ancient formula, selecting the main pharmacologically active ingredients—Gansui, Banxia, ​​Shaoyao, and prepared licorice root—which are extracted, concentrated, and mixed with a poultice matrix to form the poultice. This improves medication adherence and is extremely convenient for transportation, storage, and carrying. While Gansui has some pharmacological toxicity, the dosage of Gansui in the poultice prepared by this invention is controlled within a range that ensures efficacy while minimizing toxicity. Therefore, this poultice is safe and effective.

[0034] 2) The Gansui Banxia plaster of the present invention has a large drug loading capacity, high bioavailability, does not stain clothing, and is not likely to cause allergies. In clinical practice, it is combined with acupoint therapy and applied to the Shenque acupoint to improve the therapeutic effect and relieve ascites symptoms. Attached Figure Description

[0035] Figure 1 This is a test chart of the initial adhesion of the poultice acupoint patch.

[0036] Figure 2 This is a test chart of the peel strength of the acupoint patch.

[0037] Figure 3 This is a diagram of an in vitro permeation experiment of a poultice acupoint patch. Detailed Implementation

[0038] The mass ratio of each raw medicinal material was 3:12:5:1. After weighing according to this ratio, the materials were soaked in 75% ethanol for 2 hours. Then, using the reflux method, ten times the total mass of the medicinal materials were added to 75% ethanol, and the mixture was heated to reflux at 80℃ for 2 hours. After filtration, the alcohol extract of the medicinal materials was obtained. The residue obtained after filtration was added to ten times the amount of water, and the mixture was heated to reflux at 90℃~100℃ for 2 hours. This process was repeated twice, and the water extract of the medicinal materials was obtained after each extraction. All filtrates were combined and concentrated under reduced pressure to obtain a density of approximately 1.2 g / cm³. 3 The extract, 1g of extract is equivalent to 3g of raw herb.

[0039] Example 1

[0040] A type of acupoint patch for treating ascites, containing the following raw materials by weight percentage: 29.42% *Euphorbia kansui* and *Pinellia ternata* extract, 27.46% glycerin, 29.42% water, 0.59% aluminum hydroxyacetate, 6.47% sodium polyacrylate (NP700), 3.02% sodium carboxymethyl cellulose, 1.29% polyvinylpyrrolidone (PVP-K30), 0.04% disodium edetate, 0.88% tartaric acid, 0.59% kaolin, and 0.80% carbomer.

[0041] This invention also provides a preparation process for a poultice for treating ascites, comprising the following steps:

[0042] S1: Dissolve and mix. Weigh 0.66g polyvinylpyrrolidone (PVP-K30), 0.02g disodium edetate, 0.45g tartaric acid and 0.41g carbomer, dissolve in 15g water to obtain phase A, and set aside.

[0043] S2: Stir and mix, weigh 3.3g sodium polyacrylate (NP700), 1.54g sodium carboxymethyl cellulose, 0.3g aluminum hydroxyl and 0.3g kaolin and add them to 14g glycerol. Stir until there are no obvious particles visible to the naked eye. This is phase B. Set aside for later use.

[0044] S3: Mix 15g of Euphorbia kansui and Pinellia ternata extract, phase A, and phase B. Stir evenly using a hook mixer. After spreading and shaping the paste, cut it into pieces, pack it into an aluminum-plastic composite bag, heat and seal it, and then place it at room temperature.

[0045] Step S1 requires 12 hours, and the solution should be allowed to stand and dissolve overnight.

[0046] The stirring speed in step S2 is 80 r / min, and the stirring time is 20 min.

[0047] The coating speed in step S3 is 600 mm / min, the coating thickness is 1.5 mm, and the coating is cut into rectangles of 10 cm × 12 cm.

[0048] Example 2

[0049] A type of acupoint patch for treating ascites, containing the following raw materials by weight percentage: 30.11% *Euphorbia kansui* and *Pinellia ternata* extract, 26.10% glycerin, 30.11% water, 0.70% aluminum hydroxyacetate, 5.62% sodium polyacrylate (NP700), 2.01% sodium carboxymethyl cellulose, 2.01% polyvinylpyrrolidone (PVP-K30), 0.04% disodium edetate, 1.20% citric acid, 0.80% micronized silica gel, and 1.30% water-soluble azone.

[0050] This invention also provides a preparation process for a poultice for treating ascites, comprising the following steps:

[0051] S1: Dissolve and mix. Weigh 1g of polyvinylpyrrolidone (PVP-K30), 0.02g of disodium edetate, 0.6g of citric acid and 0.65g of water-soluble azone, dissolve in 15g of water to obtain phase A, and set aside.

[0052] S2: Stir and mix, weigh 2.8g sodium polyacrylate (NP700), 1g sodium carboxymethyl cellulose, 0.35g aluminum hydroxyl and 0.4g micronized silica powder and add them to 13g glycerol. Stir until there are no obvious particles visible to the naked eye, and obtain phase B, for later use.

[0053] S3: Mix 15g of Euphorbia kansui and Pinellia ternata extract, phase A, and phase B. Stir evenly using a hook mixer. After spreading and shaping the paste, cut it into pieces, pack it into an aluminum-plastic composite bag, heat and seal it, and then place it at room temperature.

[0054] Step S1 requires 12 hours, and the solution should be allowed to stand and dissolve overnight.

[0055] The stirring speed in step S2 is 90 r / min, and the stirring time is 30 min.

[0056] The coating speed in step S3 is 700 mm / min, the coating thickness is 2 mm, and the coating is cut into rectangles of 10 cm × 12 cm.

[0057] Example 3

[0058] A Gansui and Banxia poultice for treating ascites comprises the following raw materials by weight percentage: Gansui and Banxia extract 29.66%, propylene glycol 9.88%, glycerin 16.81%, water 28.67%, aluminum hydroxyacetate 0.79%, sodium polyacrylate (NP800) 5.34%, sodium carboxymethyl cellulose 3.56%, polyvinylpyrrolidone (PVP-K90) 0.99%, disodium edetate 0.06%, tartaric acid 0.79%, titanium dioxide 0.89%, and poloxamer 2.57%. This invention also provides a preparation process for the poultice for treating ascites, comprising the following steps:

[0059] S1: Dissolve and mix. Weigh 0.5g polyvinylpyrrolidone (PVP-K90), 0.03g disodium edetate, 0.4g tartaric acid and 1.3g poloxamer, dissolve in 14.5g water to obtain phase A, for later use.

[0060] S2: Stir and mix. Weigh 4.5g sodium polyacrylate (NP800), 1.8g sodium carboxymethyl cellulose, 0.4g aluminum hydroxyl and 0.45g titanium dioxide and add them to 5g propylene glycol and 8.5g glycerol. Stir until there are no obvious particles visible to the naked eye. This is phase B. Set aside for later use.

[0061] S3: Mix 15g of Euphorbia kansui and Pinellia ternata extract, phase A, and phase B. Stir evenly using a hook mixer. After spreading and shaping the paste, cut it into pieces, pack it into an aluminum-plastic composite bag, heat and seal it, and then place it at room temperature.

[0062] Step S1 requires 12 hours, and the solution should be allowed to stand and dissolve overnight.

[0063] The stirring speed in step S2 is 90 r / min, and the stirring time is 30 min.

[0064] The coating speed in step S3 is 900 mm / min, the coating thickness is 1 mm, and the coating is cut into rectangles of 10 cm × 12 cm.

[0065] The above embodiments were evaluated for performance, including moldability, adhesion testing and in vitro permeation experiments.

[0066] (1) Initial tack test

[0067] Initial tack test method: Follow Method 1 of the Adhesion Determination Methods in Part IV of the 2020 edition of the Chinese Pharmacopoeia. This apparatus mainly consists of an inclined plate, a base, stainless steel balls, and a ball receiving box. Adjust the inclined plate to an angle of 30°. Two horizontal lines, 10mm apart, are drawn on the plate; the upper line indicates the starting position of the steel balls, and the lower line indicates the fixed position of the top of the test sample. The base should be adjustable and maintain the horizontal state of the apparatus. The ball receiving box is used to collect the steel balls rolling off the plate, and its inner wall is lined with a soft material. The stainless steel ball size should conform to the table specified in the Pharmacopoeia. Before the test, place the poultice at 18–25°C and 40%–70% relative humidity for at least 2 hours. Wipe the surface of the inclined plate and stainless steel balls with a wiping material soaked in anhydrous ethanol, and carefully dry them with a clean, lint-free cloth. Repeat this cleaning process at least three times until the surface of the inclined plate and stainless steel balls is visually inspected and found to be clean. If all three test samples adhere to the largest steel ball, or if two of them are the largest steel ball and the third is only one size smaller, then the test meets the requirements. If one of them is the largest steel ball and the other two are only one size smaller, then three more samples should be tested. If all three samples can adhere to the largest steel ball, the test meets the requirements.

[0068] (2) Peel strength test

[0069] Peel strength test method: The test sample is cut into a rectangular shape with a length of approximately 110 mm and a width greater than 20 mm. The test plate is a stainless steel plate with a thickness of 1.5 mm to 2.0 mm, a width of 50 mm ± 1 mm, and a length of 125 mm ± 1 mm. The peel strength of the poultice is determined using the 180° peel strength test method. The adhesive side of the poultice is attached to the test plate, and a 2 kg heavy roller is used to roll back and forth on the backing of the test sample three times. After being left at room temperature for 20 minutes, the peel strength is measured. The testing machine continuously peels at an upward speed of 300 mm / min ± 10 mm / min.

[0070] The above-described poultice exhibits good formability, smoothness, and easy peeling of the protective film with no residue. It has few and small air bubbles and no visible particles. After a certain period of application, the poultice does not penetrate the fabric or clump. When applied to the back of the hand and shaken vigorously 10 times, it does not fall off. After 7 days, the poultice remains intact without any "cold flow." It is easy to apply. After repeatedly applying and removing the poultice 10 times, there is no residue and it still maintains good adhesion.

[0071] (3) In vitro permeation test

[0072] The cumulative permeation of paeoniflorin was determined using paeoniflorin as the target substance. The in vitro permeation experiment was conducted using a vertical diffusion cell with an effective diffusion area of ​​1.767 cm². 2 The receiving pool volume was 10 mL. Isolated mouse skin was placed between the supply and receiving pools, with the outer skin surface facing upwards. After fixation, blank receiving solution was added to the receiving pool. PBS solution with pH = 7.4 was used as the receiving medium. A poultice was applied to the skin, and the diffusion pool temperature was set to 32 ± 0.2℃, with a stirring speed of 600 rpm. Samples of 0.2 mL were taken at 0 h, 1 h, 2 h, 4 h, 6 h, 8 h, and 12 h, and an equal volume of blank receiving solution was added after each sampling. The PF concentration in the samples was determined by HPLC. The cumulative permeation per unit area of ​​skin (μg / cm²) was calculated using the following formula. 2 ):

[0073]

[0074] C n It is the PF concentration (μg / mL) of the nth sample, C n-1 V is the PF concentration (μg / mL) of the (n-1)th sample, and V is the volume of the receiving liquid in a single diffusion cell (10 mL). n A is the volume of each sample taken (0.2 mL), and A is the effective diffusion surface area of ​​the diffusion cell (cm²). 2 ).

[0075] The adhesion and in vitro penetration test results of the poultice in Example 1 were as follows: Initial tack test showed it could adhere to size 18 microspheres, with a peel strength of 0.589 N. The cumulative penetration per unit area over 12 hours was 198.37 μg / cm². 2 .

[0076] The adhesion and in vitro penetration test results of the poultice in Example 2 were as follows: Initial tack test showed it could adhere to size 17 microspheres, with a peel strength of 0.633 N. The cumulative penetration per unit area over 12 hours was 173.40 μg / cm². 2 .

[0077] The adhesion and in vitro penetration test results of the poultice in Example 3 were as follows: Initial tack test showed it could adhere to size 19 microspheres, with a peel strength of 0.697 N. The cumulative penetration per unit area over 12 hours was 156.88 μg / cm². 2 .

[0078] This invention strictly controls a poultice and its preparation process. By strictly controlling the proportions of raw materials and auxiliary materials and the preparation process parameters, the poultice is prepared by pulverizing Euphorbia kansui, Pinellia ternata, Paeonia lactiflora, and prepared licorice root, uniformly mixing the powders, and soaking the mixed powders. Then, using alcohol and water extraction methods, Euphorbia kansui and Pinellia ternata extract is prepared. Next, polyvinylpyrrolidone, organic acids, disodium edetate, and a transdermal penetration enhancer are dissolved in an appropriate amount of water and left overnight to obtain phase A. Sodium polyacrylate, aluminum hydroxide, sodium carboxymethyl cellulose, and fillers are then added to a humectant and stirred evenly to obtain phase B. Finally, phases A, B, and the Euphorbia kansui and Pinellia ternata extract are mixed and stirred evenly. The paste is placed between a nonwoven fabric and a release film, coated and shaped by rollers, cut, and packaged. In this poultice preparation process, the raw materials are dissolved and mixed in two steps, and all steps are carried out at room temperature without heating, simplifying the production process, making production simpler, reducing costs, and making the process simple and easy to implement.

Claims

1. A poultice acupoint patch for treating ascites, characterized in that, The raw materials, by weight percentage, are as follows: 27%-31% *Gansui* and *Banxia* extract, 25%-28% humectant, 27%-31% water, 0.5%-0.8% aluminum hydroxyl, 5%-7% sodium polyacrylate, 1.5%-4% sodium carboxymethyl cellulose, 0.9%-2.5% polyvinylpyrrolidone, 0.03%-0.06% disodium edetate, 0.2%-1.3% organic acid, 0.5%-0.9% filler, and 0.2%-2% transdermal penetration enhancer; The extract of Euphorbia kansui and Pinellia ternata is a concentrated extract of four medicinal materials: Euphorbia kansui, Pinellia ternata, Paeonia lactiflora, and Glycyrrhiza uralensis. The mass ratio of Euphorbia kansui: Pinellia ternata: Paeonia lactiflora: Glycyrrhiza uralensis is 3:12:5:

1. The moisturizer is one or both of glycerin and propylene glycol; The sodium polyacrylate is one of NP700 and NP800; The polyvinylpyrrolidone is one of PVP-K30 and PVP-K90; The organic acid is one of citric acid and tartaric acid; The filler is one of kaolin, micronized silica gel and titanium dioxide; The transdermal penetration enhancer is one of carbomer, water-soluble azone, and poloxamer.

2. The method for preparing a poultice acupoint patch for treating ascites as described in claim 1, characterized in that, Includes the following steps: S1: Weigh each raw medicinal material in the formula according to the mass ratio, soak in 75% ethanol for 2-4 hours, then use the heating reflux method to add 75% ethanol in a volume ten times the total mass of medicinal materials, heat and reflux for 2-4 hours, filter, and obtain the alcohol extract of the medicinal materials. Add ten times the amount of water to the filtered residue, heat and reflux at 90℃-100℃ for 2-4 hours, repeat twice, and filter after each extraction to obtain an aqueous extract of the medicinal material. The alcoholic extract and the aqueous extract of the combined medicinal materials were concentrated under reduced pressure to obtain an extract. S2: Dissolve polyvinylpyrrolidone, disodium edetate, organic acid and transdermal penetration enhancer in water to obtain phase A, which is then set aside. S3: Add sodium polyacrylate, aluminum hydroxyl, sodium carboxymethyl cellulose and filler to the humectant, stir well to obtain phase B, and set aside; S4: Mix the extract of Euphorbia kansui and Pinellia ternata, phase A and phase B, stir evenly with a hook stirrer, spread the paste into a shape, cut it, pack it into an aluminum-plastic composite bag, heat and seal it, and then place it at room temperature.

3. The method for preparing a poultice acupoint patch for treating ascites according to claim 2, characterized in that: In step S2, the solution is left to stand overnight to dissolve. The stirring speed in step S3 is 80 r / min-100 r / min, and the stirring time is 20-40 min; The coating speed in step S4 is 600mm / min-900mm / min, the coating thickness is 1.5mm, and it is cut into rectangles of 10cm×12cm.

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