An insulin-like growth factor mass spectrometry detection device and its usage method

Abstract

The present invention relates to the technical field of mass spectrometry detection, and specifically relates to a mass spectrometry detection device for insulin-like growth factor and its usage method, including a storage box with a storage device. A communication unit is provided on the storage box; the storage device is horizontally arranged in the storage box and there are multiple storage devices. The multiple storage devices are arranged in a ring and can rotate around the axis of the ring structure. There is a sample access position on the storage box. When the storage device rotates, it can pass through the sample access position. One end of the storage device is provided with an opening, and a plug ball is arranged at the opening. A first spring is arranged along the length direction of the storage device on the side of the plug ball far away from the opening. A thimble is horizontally arranged at the sample access position. The thimble can move horizontally and a communication groove is penetrated along the extending direction of the thimble inside the thimble. The thimble is communicated with the communication unit through the communication groove. The present invention avoids the leakage of the sample in the storage device during sampling and sample storage.

Description

Technical Field

[0001] The present invention relates to the technical field of mass spectrometry detection, and specifically relates to a mass spectrometry detection device for insulin-like growth factor and a method for using the same. Background Art

[0002] Mass spectrometry detection equipment includes a detection device and a sample storage device, and the multiple detection devices and the sample storage device are separately arranged. Thus, when performing detection, it is necessary for the staff to first take out the sample from the sample storage device and then conduct experiments. After the experiments, the sample needs to be put back. Moreover, the same sample needs to be experimented multiple times within a certain period, and the above steps need to be repeated for each experiment. Such a working process is rather cumbersome, and most samples need to be stored refrigerated. Frequent opening and closing are likely to increase the situation of external impurities mixing into the sample storage device, thereby contaminating the sample. The same situation also occurs during sample storage.

[0003] Chinese Patent Application CN118150731A discloses a liquid chromatography tandem mass spectrometer, including a base. A mass spectrometer is fixedly installed on the top of the base. A storage device is fixedly installed on the top of the mass spectrometer. A sealing door is movably installed on one side of the mass spectrometer. An injection mechanism is fixedly installed on the side of the sealing door away from the mass spectrometer; the storage device includes a support frame fixedly installed on the top of the mass spectrometer. A heat preservation box is fixedly installed on one side of the support frame close to the sealing door. A refrigerator is fixedly installed on the side of the heat preservation box away from the injection mechanism. An adjusting mechanism is fixedly installed on the rear side inside the heat preservation box. A heat preservation door is fixedly installed on the side of the heat preservation box away from the support frame. A fixing plate is fixedly installed on the side of the adjusting mechanism close to the heat preservation door. An electric conveyor belt is rotatably connected to the side of the fixing plate away from the adjusting mechanism. Storage mechanisms are rotatably connected at equal intervals along the conveying direction of the electric conveyor belt on the side of the electric conveyor belt away from the fixing plate.

[0004] Although the above solution can avoid contact with the outside world during sample storage, the method of storing samples in the above solution has a low space utilization rate. Moreover, when storing samples, the opening of the storage container needs to be vertically downward. In this way, the samples in the storage container are likely to overflow after injection. This is because the opening of the storage container is vertically downward. When the storage container is disconnected from the injection mechanism, the opening of the storage container is not closed in time, thus causing the overflow of the sample. In addition, the structure of the storage container in the above solution only allows entry and cannot achieve the discharging function. At the same time, there is only an injection mechanism without a sampling mechanism. Thus, when sampling, it is still necessary to open the heat preservation door, and the number of sampling times is several times more than the number of injection times. In this way, it will still cause sample contamination. Summary of the Invention

[0005] In view of the above problems, an insulin-like growth factor mass spectrometry detection device and its use method are provided. When storing a sample, first, the storage device needs to be located at the access sample position. Subsequently, the thimble moves horizontally towards the storage device. When the end of the thimble contacts the plug ball on the opening of the storage device, the thimble continues to move, and the thimble pushes open the plug ball blocking the opening of the storage device. The first spring connected to the plug ball is gradually compressed when the plug ball is pushed open from the opening. The end of the communication groove far from the communication unit is radially opened at the end of the thimble. Thus, when the plug ball is pushed open by the thimble, the communication unit can communicate with the storage device through the communication groove in the thimble. In this way, after the communication unit inhales the sample, it can inject the sample into the storage device through the communication groove on the thimble. When sampling, the principle is the same. Still, the plug ball blocking the opening of the storage device is pushed open by the thimble. Subsequently, the storage device communicates with the communication groove, and the communication unit can sample from the storage device through the thimble. The communication unit connected to the thimble can communicate with both the monitoring unit and the sample to be placed outside. It should be noted that there is a storage cavity in the storage device, and the storage cavity is in a ring structure. A sleeve is arranged in the storage device along the extension direction of the storage device. A first corrugated sleeve is sleeved outside the first spring, and the two ends of the first corrugated sleeve are respectively fixed to the plug ball and the end of the sleeve facing the opening of the storage device. In this way, it can be ensured that the sample in the storage device does not wrap the first spring, avoiding the inconvenience of cleaning the first spring due to its irregular shape during subsequent cleaning of the storage cavity. Therefore, sleeving the first corrugated sleeve outside the first spring can ensure that the storage cavity can be cleaned thoroughly. By horizontally setting the storage device and enabling the storage device to rotate in the storage box, the storage device can adapt to different operations of sampling or storing samples, and the number of storage devices that can be set in the storage box is more than that when the storage devices are vertically arranged. At the same time, by setting a plug ball at the opening of the storage device and pushing it open by the thimble during sampling or storing samples, the situation of sample leakage in the storage device during sampling and storing samples is avoided, thereby avoiding the pollution of the sample in the storage device.

[0006] To solve the problems of the prior art, the present invention provides an insulin-like growth factor mass spectrometry detection device, comprising a storage box for storing storage containers, and a connecting unit is arranged on the storage box; the storage containers are horizontally arranged in the storage box and a plurality of storage containers are provided, the plurality of storage containers are arranged in a ring shape and can rotate around the axis of the ring structure, a sample storage and access position is provided on the storage box, the storage containers can pass through the sample storage and access position when rotating, an opening is provided at one end of the storage container, a sealing ball is provided at the opening, a first spring is provided along the length direction of the storage container on a side of the sealing ball away from the opening, a ejector pin is horizontally provided on the sample storage and access position, the ejector pin can move in a horizontal direction, and a connecting groove is provided in the ejector pin along the extension direction of the ejector pin, the ejector pin is connected to the connecting unit through the connecting groove, and the connecting groove is radially provided at the end of the ejector pin at one end away from the connecting unit, and when the storage container rotates to the sample storage and access position, the ejector pin moves toward the opening of the storage container and pushes open the sealing ball blocking the opening.

[0007] Preferably, an extension tube is fixedly provided at the opening of the storage container along the extension direction of the opening, and the ejector pin needs to pass through the extension tube before entering the opening of the storage container. The inner diameter of the extension tube is the same as the outer diameter of the ejector pin, and a sealing ring is provided on the inner wall of the extension tube.

[0008] Preferably, a sliding plate is provided in the storage container for sliding along the length direction of the storage container, and a storage cavity is formed on the side of the sliding plate facing the opening of the storage container. The ejector pin can inject the sample into the storage cavity or take out the sample from the storage cavity through the connecting groove. When the sample is injected into the storage cavity, the sliding plate slides in a direction away from the opening of the storage container, and when the sample is taken out of the storage cavity, the sliding plate slides in a direction close to the opening of the storage container.

[0009] Preferably, a cleaning position is also provided on the storage box, and the cleaning position is located above the sample storage and access position. A cleaning unit is provided on the cleaning position, and the cleaning unit includes a connecting sleeve that moves in a horizontal direction, and a water injection pipe for supplying water to the connecting sleeve is provided at the end of the connecting sleeve, and a drain port is provided on the side wall of the storage container, and a drain valve is provided on the drain port. When the connecting sleeve is arranged at the opening of the storage container, the water injection pipe supplies water to the connecting sleeve and the drain valve is opened, and the water flow pushes open the sealing ball and flushes the storage cavity.

[0010] Preferably, a pre-opening unit is provided on the storage container, and the pre-opening unit includes a first electromagnet arranged on one side of the storage container. A pulling tube is movably arranged in the storage container, and the end of the pulling tube facing the opening of the storage container is fixedly connected to the sealing ball. The end of the pulling tube away from the opening of the storage container can be attracted by the first electromagnet. When the storage container needs to be cleaned and reaches the cleaning position and the connecting sleeve is arranged on the opening of the storage container, the first electromagnet is energized.

[0011] Preferably, a rangefinder is provided on one side of the storage device. The measuring end of the rangefinder points horizontally at the sliding plate. The rangefinder is used to measure the straight-line distance between the rangefinder and the sliding plate. The rangefinder is preset with a rated distance. When the measured value of the rangefinder reaches the rated distance, the first electromagnet is energized when it reaches the cleaning position.

[0012] Preferably, a rotating frame is provided in the storage box. The rotating frame is a ring-shaped bracket structure. The storage devices are arranged in the storage box and evenly arranged on the rotating frame around the axis of the rotating frame. A toothed ring is provided at the end of the rotating frame. A first rotary driver for driving the toothed ring to rotate is provided on one side of the toothed ring.

[0013] Preferably, a second electromagnet is fixedly provided on the side wall of the storage box. The second electromagnet is a ring-shaped structure. The ejector pin passes through the inner ring of the second electromagnet and is slidably matched with the second electromagnet. The magnetic attraction plate is fixedly provided at the end of the ejector pin away from the storage device. There is a gap between the magnetic attraction plate and the second electromagnet. The second spring is arranged in the gap along the moving direction of the ejector pin, and both ends of the second spring are fixedly connected to the second electromagnet and the magnetic attraction plate respectively.

[0014] Preferably, a blocking unit is provided on the inner wall of the storage box on the side of the ejector pin facing the storage device. The blocking unit is opened before the ejector pin moves towards the storage device and is closed after the ejector pin withdraws from the opening of the storage device. The first connecting pipe is provided at the end of the ejector pin away from the storage device and is communicated with the communication groove. A pump body is provided on the first connecting pipe. A second reversing valve is provided at the end of the first connecting pipe away from the ejector pin. There is a cleaning groove on the side wall of the storage box after the blocking unit blocks the end of the ejector pin. A drain groove is provided at the lower part of the cleaning groove.

[0015] The present invention also relates to a method for using a mass spectrometry detection device for insulin-like growth factor. A mass spectrometry detection device for insulin-like growth factor is adopted, and the specific steps are as follows:

[0016] S1. There is a control panel on the storage box. Through the control panel, select the storage device that needs to store or sample the sample, so that the selected storage device rotates to the access sample position and then stops rotating.

[0017] S2. The ejector pin moves horizontally towards the opening of the storage device and pushes open the blocking ball blocking the opening of the storage device. The first spring is compressed. The storage device is communicated with the communication unit through the communication groove on the ejector pin. The communication unit can sample or store the sample through the communication groove on the ejector pin.

[0018] S3. After storing or sampling is completed, the ejector pin moves horizontally away from the storage device. The blocking ball blocks the opening of the storage device under the elastic force of the first spring.

[0019] The beneficial effects of the present invention compared with the prior art are:

[0020] 1. When the present invention stores a sample, first, the storage device needs to be located at the access sample position. Subsequently, the ejector pin moves horizontally towards the storage device. When the end of the ejector pin contacts the plug ball on the opening of the storage device, the ejector pin continues to move. The ejector pin pushes open the plug ball blocking the opening of the storage device, and the first spring connected to the plug ball is gradually compressed when the plug ball is pushed open from the opening. And the end of the communication groove far from the communication unit is radially opened at the end of the ejector pin. Thus, when the plug ball is pushed open by the ejector pin, the communication unit can be connected to the storage device through the communication groove in the ejector pin. In this way, after the communication unit sucks the sample, it can inject the sample into the storage device through the communication groove on the ejector pin. When sampling, the principle is the same. Still, the plug ball blocking the opening of the storage device is pushed open by the ejector pin. Subsequently, the storage device is connected to the communication groove, and the communication unit can sample from the storage device through the ejector pin. The communication unit connected to the ejector pin can be connected to both the monitoring unit and the sample to be put in from the outside. It should be noted that there is a storage cavity in the storage device. The storage cavity is of an annular structure. A sleeve is arranged in the storage device along the extending direction of the storage device. A first corrugated sleeve is sleeved outside the first spring. The two ends of the first corrugated sleeve are respectively fixedly connected to the plug ball and the end of the sleeve facing the opening of the storage device. In this way, it can be ensured that the sample in the storage device does not wrap the first spring, avoiding that when the storage cavity is cleaned subsequently, the first spring is not easy to clean due to its irregular shape. Therefore, sleeving the first corrugated sleeve outside the first spring can ensure that the storage cavity can be cleaned cleanly. By horizontally arranging the storage device and enabling the storage device to rotate in the storage box, the storage device can adapt to different operations of sampling or storing samples, and the number of storage devices that can be set in the storage box is more than that when the storage devices are arranged vertically. At the same time, by setting a plug ball at the opening of the storage device and pushing it open by the ejector pin during sample storage or sampling, the situation of sample leakage in the storage device during sampling and sample storage is avoided, thereby avoiding the pollution of the sample in the storage device.

[0021] 2. A sliding plate is arranged in the storage device, enabling the sliding plate to slide in the storage device during sample storage and sampling. In this way, the volume of the storage cavity can be arbitrarily changed according to sampling or sample storage, thereby avoiding obstacles during sample storage or sampling. Description of the Drawings

[0022] Figure 1 is a three-dimensional schematic of an insulin-like growth factor mass spectrometry detection device Figure 1 。

[0023] Figure 2 is a three-dimensional schematic of an insulin-like growth factor mass spectrometry detection device Figure 2 。

[0024] Figure 3 is an insulin-like growth factor mass spectrometry detection deviceFigure 2 Partial enlarged schematic view at position A.

[0025] Figure 4 Side view of a mass spectrometry detection device for insulin-like growth factor.

[0026] Figure 5 It is a Figure 4 Cross-sectional schematic view at B-B.

[0027] Figure 6 It is a Figure 5 Partial enlarged schematic view at position C.

[0028] Figure 7 Cutaway three-dimensional schematic view of a mass spectrometry detection device for insulin-like growth factor.

[0029] Figure 8 It is a Figure 7 Partial enlarged schematic view at position D.

[0030] Figure 9 It is a Figure 7 Partial enlarged schematic view at position E.

[0031] Figure 10 It is a Figure 7 Partial enlarged schematic view at position F.

[0032] Figure 11 Three-dimensional schematic view of the connection unit of a mass spectrometry detection device for insulin-like growth factor.

[0033] Figure 12 Cutaway three-dimensional schematic view of a storage device with a thimble at the opening of a mass spectrometry detection device for insulin-like growth factor.

[0034] The reference numerals in the figure are:

[0035] 1. Storage box; 2. Connecting unit; 21. Sealing unit; 211. Second rotary driver; 212. Sealing disc; 213. Second gear; 22. First connecting pipe; 23. Second reversing valve; 24. Pump body; 25. Drainage groove; 26. Second connecting pipe; 3. Storage device; 31. Sealing ball; 32. First spring; 321. First corrugated sleeve; 322. Sleeve; 33. Extension pipe; 34. Sliding plate; 341. First limiting ring; 342. Second limiting ring; 4. Thimble; 41. Connecting groove; 42. Second electromagnet; 43. Magnetic attraction plate; 44. Second spring; 5. Cleaning unit; 51. Connecting sleeve; 52. Water injection pipe; 53. Drainage valve; 54. Electric push rod; 55. Rubber sleeve; 6. Pre-opening unit; 61. First electromagnet; 62. Pulling pipe; 63. Rangefinder; 631. Second corrugated sleeve; 7. Rotating frame; 71. Tooth ring; 72. First rotary driver; 73. First gear. Detailed implementation manner

[0036] To further understand the features, technical means, specific purposes, and functions achieved by the present invention, the present invention will be described in further detail below in conjunction with the accompanying drawings and specific implementation manners.

[0037] Refer to Figure 1 , Figure 2 , Figure 5 , Figure 6 , Figure 11 and Figure 12 : An insulin-like growth factor mass spectrometry detection device, including a storage box 1 storing a storage device 3, and a connecting unit 2 is provided on the storage box 1; the storage device 3 is horizontally arranged in the storage box 1 and there are multiple storage devices 3, and the multiple storage devices 3 are arranged in a ring and can rotate around the axis of the ring structure. There is an access sample position on the storage box 1. When the storage device 3 rotates, it can pass through the access sample position. One end of the storage device 3 is provided with an opening, a sealing ball 31 is arranged at the opening, a first spring 32 is arranged along the length direction of the storage device 3 on the side of the sealing ball 31 away from the opening. A thimble 4 is horizontally arranged at the access sample position. The thimble 4 can move horizontally and a connecting groove 41 is axially penetrated along the extending direction of the thimble 4 inside the thimble 4. The thimble 4 is interconnected with the connecting unit 2 through the connecting groove 41. The end of the connecting groove 41 away from the connecting unit 2 is radially opened at the end of the thimble 4. When the storage device 3 rotates to the access sample position, the thimble 4 moves towards the opening of the storage device 3 and pushes open the sealing ball 31 blocking the opening.

[0038] On one side of the storage box 1, a detection unit is also provided. An injection port is provided on the detection unit. The detection unit is preferably a mass spectrometer. The communication unit 2 provided on the storage box 1 can be used for both sampling and sample storage. For the sake of convenience of description, insulin-like growth factor will be simply referred to as a sample hereinafter. The sample can be stored in the storage device 3. The storage box 1 is provided with a sample access position and a cleaning position. The storage device 3 rotatably arranged in the storage box 1 can be rotated to the sample access position and the cleaning position respectively by rotation. When it is necessary to store the sample in or take the sample out of the storage device 3, at this time, the storage device 3 needs to be rotated to the sample access position, and then the communication unit 2 is made to communicate with the storage device 3, so as to realize the functions of sample storage and sampling. The cleaning position provided on the storage box 1 can clean the storage device 3. That is, when the sample in the storage device 3 is completely taken out, a part of the sample residue will remain in the storage device 3. In order to ensure that the storage device 3 can be recycled without taking the storage device 3 out of the storage box 1 for cleaning, in this way, the situation that foreign impurities accidentally enter the storage box 1 during the process of taking out the storage device 3 for cleaning can be avoided, thereby causing pollution to the opening of the storage device 3 in the storage box 1. The working principle of the sample storage and sampling steps of the storage device 3 is as follows. When storing the sample, first, the storage device 3 needs to be located at the sample access position, and then the thimble 4 moves horizontally towards the storage device 3. When the end of the thimble 4 contacts the plugging ball 31 on the opening of the storage device 3, the thimble 4 continues to move. The thimble 4 pushes the plugging ball 31 blocking the opening of the storage device 3 away. The first spring 32 connected to the plugging ball 31 is gradually compressed when the plugging ball 31 is pushed away from the opening. And the end of the communication groove 41 far away from the communication unit 2 is radially opened at the end of the thimble 4. In this way, when the plugging ball 31 is pushed away by the thimble 4, the communication unit 2 can communicate with the storage device 3 through the communication groove 41 in the thimble 4. In this way, after the communication unit 2 sucks the sample, it can inject the sample into the storage device 3 through the communication groove 41 on the thimble 4. When sampling, the principle is the same. It is still to push the plugging ball 31 blocking the opening of the storage device 3 away by the thimble 4. Then the storage device 3 communicates with the communication groove 41, and the communication unit 2 can sample from the storage device 3 through the thimble 4. The communication unit 2 connected to the thimble 4 can communicate with both the monitoring unit and the sample that needs to be put in from the outside. It should be noted that a storage cavity is provided in the storage device 3. The storage cavity is of an annular structure. A sleeve 322 is arranged in the storage device 3 along the extending direction of the storage device 3. A first corrugated sleeve 321 is sleeved outside the first spring 32. The two ends of the first corrugated sleeve 321 are respectively fixedly connected to the plugging ball 31 and the end of the sleeve 322 facing the opening of the storage device 3. In this way, it can be ensured that the sample in the storage device 3 will not wrap the first spring 32, avoiding that when the storage cavity is cleaned subsequently, the first spring 32 is not easy to clean due to its special-shaped structure. Therefore, sleeving the first corrugated sleeve 321 outside the first spring 32 can ensure that the storage cavity can be cleaned cleanly. By horizontally arranging the storage device 3 and enabling the storage device 3 to rotate in the storage box 1,The register 3 can be adapted to different sampling or sample storage operations, and the number of registers 3 that can be set in the storage box 1 is more than that when the register 3 is set vertically. At the same time, by setting a blocking ball 31 at the opening of the register 3 and pushing it open by the ejector pin 4 during sample storage or sampling, the leakage of the sample in the register 3 during sampling and sample storage is avoided, and thus the contamination of the sample in the register 3 is avoided.

[0039] Refer to Figure 7 : An extension tube 33 is fixedly arranged along the extension direction of the opening at the opening of the register 3. Before the ejector pin 4 enters the opening of the register 3, it needs to pass through the extension tube 33 first. The inner diameter of the extension tube 33 is the same as the outer diameter of the ejector pin 4, and a sealing ring is arranged on the inner wall of the extension tube 33.

[0040] When the end of the ejector pin 4 is inserted into the extension tube 33, the radially arranged communication grooves 41 on the end of the ejector pin 4 are no longer communicated with the outside world. The sealing ring located in the extension tube 33 can completely wrap the outer peripheral wall of the ejector pin 4. In this way, the communication grooves 41 on the end of the ejector pin 4 facing the opening of the register 3 are completely separated from the outside world. When the ejector pin 4 pushes open the blocking ball 31 at the opening, there will be no overflow at the opening.

[0041] Refer to Figure 12 : A sliding plate 34 is slidably arranged along the length direction of the register 3 in the register 3. A storage cavity is formed on the side of the sliding plate 34 facing the opening of the register 3. The ejector pin 4 can inject the sample into the storage cavity or take out the sample from the storage cavity through the communication grooves 41. When the sample is injected into the storage cavity, the sliding plate 34 slides in a direction away from the opening of the register 3. When the sample is taken out from the storage cavity, the sliding plate 34 slides in a direction close to the opening of the register 3.

[0042] The volume of the traditional storage container 3 is mostly fixed. After the connection unit 2 is connected to the opening of the traditional storage container 3, whether it is sampling or storing samples, it is difficult to store or sample. Unless the entire storage container 3 is taken out and manual sampling or storing is used, it is easy to cause external impurities to mix into the sample and contaminate the sample. A sliding plate 34 is provided in the storage container 3. In this way, when storing or sampling, the volume of the storage cavity in the storage container 3 can be changed arbitrarily, and there will be no situation where storing or sampling is blocked. A first limiting ring 341 and a second limiting ring 342 are respectively provided on the inner wall of the storage container 3 along the extending direction of the storage container 3. When the sliding plate 34 slides in the storage container 3, it is always located between the first limiting ring 341 and the second limiting ring 342. The first limiting ring 341 is closer to the opening of the storage container 3 than the second limiting ring 342. Therefore, when the sliding plate 34 is on one side of the first limiting ring 341, the volume of the storage cavity is the smallest, and at this time, the sample in the storage cavity cannot be taken out again and needs to be cleaned before it can be used for the second time. When the limiting plate is on one side of the second limiting ring 342, the volume of the storage cavity is the largest, and at this time, the amount of sample in the storage cavity is the largest.

[0043] Refer to Figures 5 - 7 : A cleaning position is also provided on the storage box 1. The cleaning position is above the access sample position. A cleaning unit 5 is provided on the cleaning position. The cleaning unit 5 includes a connecting sleeve 51 that moves horizontally. A water injection pipe 52 for supplying water to the connecting sleeve 51 is provided at the end of the connecting sleeve 51. A drain port is opened on the side wall of the storage container 3, and a drain valve 53 is provided on the drain port. When the connecting sleeve 51 is sleeved on the opening of the storage container 3, the water injection pipe 52 supplies water to the connecting sleeve 51 and the drain valve 53 is opened, and the water flow will push open the blocking ball 31 and flush the storage cavity.

[0044] A rubber sleeve 55 is fixedly sleeved on the end of the connecting sleeve 51 facing the storage container 3. When the connecting sleeve 51 is connected to the opening of the storage container 3, the connecting sleeve 51 can be tightly connected to the storage container 3. An electric push rod 54 is horizontally and fixedly provided on the storage box 1. The end of the electric push rod 54 is fixedly connected to the connecting sleeve 51. The electric push rod 54 is used to drive the connecting sleeve 51 to move horizontally. A first reversing valve is provided at the end of the water injection pipe 52. The first reversing valve is a two-position reversing valve, and a water pump and an air pump are respectively connected to the two positions. The water pump is started first. The water pump pumps water into the storage container 3 through the water injection pipe 52 and flows out from the drain valve 53 on the storage container 3. And when the storage container 3 rotates to the cleaning position, the drain valve 53 on the storage container 3 is in a vertical state and is located below the storage container 3. In this way, it is more conducive to the water flow entering the storage container 3 to flow out. After the cleaning is completed, the first reversing valve changes direction and the air pump is started. The air pump blows dry gas into the storage container 3, so that the residual water stains in the storage container 3 can be dried. Figure 6 The direction indicated by the arrow in is the flow direction of the water flow used to clean the storage container 3 when the cleaning unit 5 cleans the storage container 3.

[0045] Refer to Figure 7 and Figure 9 : A pre-opening unit 6 is provided on the storage device 3. The pre-opening unit 6 includes a first electromagnet 61 provided on one side of the storage device 3. A pull tube 62 is movably arranged in the storage device 3. The end of the pull tube 62 facing the opening of the storage device 3 is fixedly connected to the plugging ball 31. One end of the pull tube 62 away from the opening of the storage device 3 can be attracted by the first electromagnet 61. When the storage device 3 needs to be cleaned and reaches the cleaning position and the connecting sleeve 51 is sleeved on the opening of the storage device 3, the first electromagnet 61 is powered on.

[0046] The pull tube 62 is slidably arranged in the sleeve 322. When the storage device 3 needs to be cleaned, the storage device 3 rotates to the cleaning position. Subsequently, the first electromagnet 61 is powered on, and the pull tube 62 is attracted by the first electromagnet 61. The pull tube 62 pulls the plugging ball 31 out of the opening of the storage device 3. In this way, when the cleaning unit 5 cleans the storage device 3, there is no need to push open the plugging ball 31. In this way, the water flow pressure entering the storage cavity will not be lost, thereby ensuring the cleaning effect.

[0047] Refer to Figure 9 and Figure 12 : A rangefinder 63 is provided on one side of the storage device 3. The measuring end of the rangefinder 63 points horizontally to the sliding plate 34. The rangefinder 63 is used to measure the straight-line distance between the rangefinder 63 and the sliding plate 34. The rangefinder 63 is preset with a rated distance. When the measured value of the rangefinder 63 reaches the rated distance, the first electromagnet 61 is powered on when it reaches the cleaning position.

[0048] A second corrugated sleeve 631 is sleeved on the periphery of the rangefinder 63. The second corrugated sleeve 631 can confine the rangefinder 63 in a sealed space, so that the rangefinder 63 will not be interfered by the outside when measuring the sliding plate 34.

[0049] Refer to Figure 7 and Figure 8 : A rotating frame 7 is provided in the storage box 1. The rotating frame 7 is a ring-shaped bracket structure. The storage device 3 is arranged in the storage box 1 and is evenly arranged on the rotating frame 7 around the axis of the rotating frame 7. A toothed ring 71 is provided at the end of the rotating frame 7. A first rotary driver 72 for driving the toothed ring 71 to rotate is provided on one side of the toothed ring 71.

[0050] A first gear 73 is fixedly provided on the output end of the first rotary driver 72. The first gear 73 and the toothed ring 71 are meshed with each other. The first rotary driver 72 is preferably a servo motor. When the first rotary driver 72 drives the first gear 73 to rotate, the first gear 73 can drive the toothed ring 71 to rotate, thereby causing the rotating frame 7 to rotate. The rotating frame 7 can drive the storage device 3 to rotate to the cleaning position or the sample storage position.

[0051] Refer to Figure 10 : A second electromagnet 42 is fixedly arranged on the side wall of the storage box 1. The second electromagnet 42 is of an annular structure. The ejector pin 4 passes through the inner ring of the second electromagnet 42 and is slidably matched with the second electromagnet 42. A magnetic attraction plate 43 is fixedly arranged at one end of the ejector pin 4 away from the storage 3. There is a gap between the magnetic attraction plate 43 and the second electromagnet 42. A second spring 44 is arranged in the gap along the moving direction of the ejector pin 4, and both ends of the second spring 44 are fixedly connected to the second electromagnet 42 and the magnetic attraction plate 43 respectively.

[0052] When sampling or retrieving samples is required, the storage 3 rotates to the access sample position. Subsequently, the second electromagnet 42 is energized, and the second electromagnet 42 attracts the magnetic attraction plate 43, compressing the second spring 44. At this time, the ejector pin 4 can move horizontally and insert from the opening of the storage 3. Similarly, if the second electromagnet 42 is de-energized, the magnetic attraction plate 43 resets under the drive of the second spring 44, and in this way, the ejector pin 4 can slide out from the opening of the storage 3.

[0053] Refer to Figure 2 、 Figure 3 、 Figure 7 、 Figure 10 and Figure 11 : A plugging unit 21 is arranged on the inner wall of the storage box 1 on the side of the ejector pin 4 facing the storage 3. The plugging unit 21 is opened before the ejector pin 4 moves towards the storage 3 and is closed after the ejector pin 4 withdraws from the opening of the storage 3. A first communication pipe 22 is arranged at the end of the ejector pin 4 away from the storage 3 and is communicated with the communication groove 41. A pump body 24 is arranged on the first communication pipe 22. A second reversing valve 23 is arranged at the end of the first communication pipe 22 away from the ejector pin 4. There is a cleaning groove on the side wall of the storage box 1 after the plugging unit 21 plugs the end of the ejector pin 4, and a drain groove 25 is arranged at the lower part of the cleaning groove.

[0054] The blocking unit 21 includes a second rotation driver 211, a blocking disk 212, a blocking groove and a second gear 213. The blocking disk 212 is rotatably arranged at the front end of the ejector pin 4. The blocking disk 212 is arranged on the inner wall of the storage box 1. The blocking groove is opened on the blocking disk 212 along the axis of the blocking disk 212. When the blocking disk 212 rotates, the blocking groove can be driven to rotate to the front end of the ejector pin 4. When the blocking groove coincides with the front end of the ejector pin 4, the blocking unit 21 is in an open state. When the blocking groove is offset from the ejector pin 4, the blocking unit 21 is in a closed state. Meshing teeth are evenly arranged on the peripheral wall of the blocking disk 212. A second gear 213 is arranged on one side of the blocking disk 212. The second gear 213 meshes with the meshing teeth on the blocking disk 212. The second rotation driver 211 is arranged at the end of the second gear 213. The second rotation driver 211 is preferably a servo motor. A second connecting pipe 26 is provided on the side of the second reversing valve 23 away from the first connecting pipe 22. The second connecting pipe 26 can be connected to the mass spectrometer or connected to a new sample from the outside. It is worth noting that the second connecting pipe 26 needs to be replaced each time sampling or storing. The second reversing valve 23 is a two-position two-way reversing valve. There are two positions on the second reversing valve 23. When one of the positions of the second reversing valve 23 is connected, the first connecting pipe 22 and the second connecting pipe 26 are connected. At this time, the blocking unit 21 is in an open state. After the second reversing valve 23 is reversed, the first connecting pipe 22 and the second connecting pipe 26 are disconnected. The second reversing valve 23 can supply clean water from the outside to the first connecting pipe 22. At this time, the blocking unit 21 is in a blocked state. Clean water flows from the first connecting pipe 22 into the connecting groove 41 of the ejector pin 4, and flows out from the drainage groove 25 after being discharged into the cleaning groove, thereby completing the self-cleaning function of the connecting unit 2.

[0055] Reference Figures 1 - 12 The present invention also relates to a method for using an insulin-like growth factor mass spectrometry detection device, which uses an insulin-like growth factor mass spectrometry detection device, and the specific steps are as follows:

[0056] S1. A control panel is provided on the storage box 1. The storage container 3 for storing or taking samples is selected through the control panel, so that the selected storage container 3 rotates to the sample storage and retrieval position and then stops rotating.

[0057] S2, the ejector pin 4 moves horizontally toward the opening of the storage container 3 and pushes away the blocking ball 31 blocking the opening of the storage container 3, the first spring 32 is compressed, the storage container 3 is connected with the connecting unit 2 through the connecting groove 41 on the ejector pin 4, and the connecting unit 2 can take samples or store samples through the connecting groove 41 on the ejector pin 4.

[0058] S3. After the sample is stored or taken out, the ejector pin 4 moves horizontally away from the storage container 3, and the blocking ball 31 blocks the opening of the storage container 3 under the elastic force of the first spring 32.

[0059] The above embodiments merely represent one or several implementation manners of the present invention. The description thereof is relatively specific and detailed, but it should not be construed as a limitation to the scope of the present invention. It should be noted that for those of ordinary skill in the art, without departing from the concept of the present invention, several variations and improvements can still be made, and these all belong to the protection scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the appended claims.

Claims

1. An insulin-like growth factor mass spectrometry detection device, comprising a storage box (1) storing a storage device (3), wherein a connecting unit (2) is arranged on the storage box (1); It is characterized in that The storage container (3) is horizontally arranged in the storage box (1) and a plurality of the storage containers (3) are provided. The plurality of storage containers (3) are arranged in a ring shape and can rotate around the axis of the ring structure. A sample storage and access position is provided on the storage box (1). The storage container (3) can pass through the sample storage and access position when rotating. An opening is provided at one end of the storage container (3). A sealing ball (31) is provided at the opening. A first spring (32) is provided on the side of the sealing ball (31) away from the opening along the length direction of the storage container (3). A push pin (4) is provided, the push pin (4) can move in a horizontal direction and a connecting groove (41) is provided in the push pin (4) along the extension direction of the push pin (4). The push pin (4) is connected to the connecting unit (2) through the connecting groove (41). The end of the connecting groove (41) away from the connecting unit (2) is radially opened at the end of the push pin (4). When the storage container (3) rotates to the sample storage and access position, the push pin (4) moves toward the opening of the storage container (3) and pushes open the blocking ball (31) blocking the opening. An extension tube (33) is fixedly arranged at the opening of the storage container (3) along the extension direction of the opening. The ejector pin (4) needs to pass through the extension tube (33) before entering the opening of the storage container (3). The inner diameter of the extension tube (33) is the same as the outer diameter of the ejector pin (4). A sealing ring is arranged on the inner wall of the extension tube (33).

2. The mass spectrometry detection device for insulin-like growth factor according to claim 1, characterized in that: A sliding plate (34) is slidably arranged in the storage container (3) along the length direction of the storage container (3), and a storage cavity is formed on the side of the sliding plate (34) facing the opening of the storage container (3). The ejector pin (4) can inject the sample into the storage cavity through the connecting groove (41) or take the sample out of the storage cavity through the connecting groove (41). When the sample is injected into the storage cavity, the sliding plate (34) slides in a direction away from the opening of the storage container (3), and when the sample is taken out of the storage cavity, the sliding plate (34) slides in a direction close to the opening of the storage container (3).

3. The mass spectrometry detection device for insulin-like growth factor according to claim 2, characterized in that: A cleaning position is also provided on the storage box (1), and the cleaning position is located above the sample storage and access position. A cleaning unit (5) is provided on the cleaning position. The cleaning unit (5) comprises a connecting sleeve (51) that moves in a horizontal direction. A water injection pipe (52) for supplying water to the connecting sleeve (51) is provided at the end of the connecting sleeve (51). A drainage port is provided on the side wall of the storage container (3), and a drainage valve (53) is provided on the drainage port. When the connecting sleeve (51) is sleeved on the opening of the storage container (3), the water injection pipe (52) supplies water to the connecting sleeve (51) and the drainage valve (53) is opened, so that the water flow pushes the sealing ball (31) open and flushes the storage cavity.

4. The mass spectrometry detection device for insulin-like growth factor according to claim 3, characterized in that: A pre-opening unit (6) is arranged on the storage container (3), and the pre-opening unit (6) comprises a first electromagnet (61) arranged on one side of the storage container (3). A pulling tube (62) is movably arranged in the storage container (3), and the end of the pulling tube (62) facing the opening of the storage container (3) is fixedly connected to the blocking ball (31). The end of the pulling tube (62) away from the opening of the storage container (3) can be attracted by the first electromagnet (61). When the storage container (3) needs to be cleaned and reaches the cleaning position and the connecting sleeve (51) is sleeved on the opening of the storage container (3), the first electromagnet (61) is energized.

5. The mass spectrometry detection device for insulin-like growth factor according to claim 4, characterized in that: A distance meter (63) is arranged on one side of the storage device (3), and a measuring end of the distance meter (63) is horizontally pointed to the sliding plate (34). The distance meter (63) is used to measure the straight-line distance between the distance meter (63) and the sliding plate (34). The distance meter (63) is preset with a rated distance. When the value measured by the distance meter (63) reaches the rated distance, the first electromagnet (61) is energized when it reaches the cleaning position.

6. The mass spectrometry detection device for insulin-like growth factor according to claim 1, characterized in that: A rotating frame (7) is arranged in the storage box (1), and the rotating frame (7) is an annular support structure. The storage container (3) is arranged in the storage box (1) and is evenly arranged on the rotating frame (7) around the axis of the rotating frame (7). A gear ring (71) is arranged at the end of the rotating frame (7), and a first rotary driver (72) for driving the gear ring (71) to rotate is arranged on one side of the gear ring (71).

7. The mass spectrometry detection device for insulin-like growth factor according to claim 1, characterized in that: A second electromagnet (42) is fixedly arranged on the side wall of the storage box (1). The second electromagnet (42) is an annular structure. The ejector pin (4) passes through the inner ring of the second electromagnet (42) and is slidably matched with the second electromagnet (42). The magnetic attraction plate (43) is fixedly arranged on the end of the ejector pin (4) away from the storage container (3). There is a gap between the magnetic attraction plate (43) and the second electromagnet (42). A second spring (44) is arranged in the gap along the moving direction of the ejector pin (4) and the two ends of the second spring (44) are fixedly connected to the second electromagnet (42) and the magnetic attraction plate (43) respectively.

8. The mass spectrometry detection device for insulin-like growth factor according to claim 1, characterized in that: A blocking unit (21) is provided on the inner wall of the storage box (1) on the side where the ejector pin (4) faces the storage container (3). The blocking unit (21) is opened before the ejector pin (4) moves toward the storage container (3) and is closed after the ejector pin (4) is withdrawn from the opening of the storage container (3). A first connecting pipe (22) is provided at the end of the ejector pin (4) away from the storage container (3) and is connected to the connecting groove (41). A pump body (24) is provided on the first connecting pipe (22). A second reversing valve (23) is provided at the end of the first connecting pipe (22) away from the ejector pin (4). A cleaning groove is provided on the side wall of the storage box (1) after the end of the ejector pin (4) is blocked by the blocking unit (21). A drainage groove (25) is provided at the bottom of the cleaning groove.

9. A method for using an insulin-like growth factor mass spectrometry detection device, using an insulin-like growth factor mass spectrometry detection device according to any one of claims 1 to 8, characterized in that: The specific steps are as follows: S1. A control panel is provided on the storage box (1), and a storage container (3) for storing or taking samples is selected through the control panel, so that the selected storage container (3) rotates to the sample storage and retrieval position and then stops rotating; S2, the ejector pin (4) moves toward the opening of the storage container (3) in the horizontal direction and pushes open the blocking ball (31) blocking the opening of the storage container (3), the first spring (32) is compressed, the storage container (3) is connected to the connecting unit (2) through the connecting groove (41) on the ejector pin (4), and the connecting unit (2) can take samples or store samples through the connecting groove (41) on the ejector pin (4); S3. After the sample is stored or taken out, the ejector pin (4) moves horizontally in a direction away from the storage container (3), and the blocking ball (31) blocks the opening of the storage container (3) under the elastic force of the first spring (32).

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