Biopsy sampling box and biopsy device

Abstract

One or more embodiments of the invention relate to a biopsy sampling box and a biopsy device. The biopsy sampling box comprises a box body, a cleaning part and a transmission mechanism, the transmission mechanism is arranged in the box body and is in transmission connection with the sweeping component to drive the sweeping component to swing; a needle passing hole is formed in the box body, the sampling needle can pass through the needle passing hole, and the sweeping end on the sweeping component can sweep over at least part of the area of the sampling needle through swinging of the sweeping component.

Description

Technical Field

[0001] The present specification relates to the technical field of medical devices, and in particular to a biopsy sampling box and a biopsy device. Background Art

[0002] Currently, for clinical chest and abdominal biopsy puncture surgeries, the disposable handheld biopsy guns used by doctors can only perform single punctures and single sampling. After each puncture, the biopsy sample needs to be manually removed and placed in a reagent bottle containing formalin solution. Breast biopsy puncture surgery usually uses a large-aperture electrosurgical biopsy gun for single puncture and multiple sampling. The principle is to extract the biopsy sample from the sampling needle into the sampling box in the form of vacuum negative pressure. Both of the above biopsy puncture surgeries require doctors to manually transfer the obtained biopsy samples, which is difficult to operate and has cumbersome steps, reducing the operational efficiency of biopsy puncture.

[0003] In order to solve the above problems, this specification provides a biopsy sampling box to simplify the biopsy puncture operation steps, save doctors' time, and improve the efficiency of biopsy puncture operations. Summary of the invention

[0004] One of the embodiments of the present specification provides a biopsy sampling box, including a box body, a cleaning component and a transmission mechanism; the transmission mechanism is arranged in the box body, and the transmission mechanism is connected to the cleaning component to drive the cleaning component to swing; a needle hole is provided on the box body, and the needle hole is used for a sampling needle to pass through, and the swing of the cleaning component can make the cleaning end of the cleaning component sweep over at least a partial area of ​​the sampling needle.

[0005] One of the embodiments of the present specification provides a biopsy device, including a biopsy instrument and the biopsy sampling box of the aforementioned embodiment; the biopsy sampling box is installed on the biopsy instrument; the biopsy instrument is used to obtain a biopsy sample, and the biopsy sampling box is used to collect the biopsy sample. BRIEF DESCRIPTION OF THE DRAWINGS

[0006] This specification will be further described in the form of exemplary embodiments, which will be described in detail by the accompanying drawings. These embodiments are not restrictive, and in these embodiments, the same number represents the same structure, wherein:

[0007] Figure 1 is a schematic diagram of the structure of a biopsy sampling box according to some embodiments of this specification;

[0008] Figure 2 is a schematic diagram of the working principle of the biopsy sampling box shown in some embodiments of this specification;

[0009] Figure 3is a schematic diagram of the structure of a biopsy sampling box according to other embodiments of this specification;

[0010] Figure 4 It is a schematic diagram of the structure of the biopsy sampling box shown in some embodiments of this specification when the box body is not provided;

[0011] Figure 5 is a cross-sectional schematic diagram of a biopsy sampling box according to some embodiments of this specification;

[0012] Figure 6 is a cross-sectional schematic diagram of a biopsy sampling box according to other embodiments of this specification;

[0013] Figure 7 is a schematic diagram of the structure of a biopsy device according to some embodiments of this specification;

[0014] Figure 8 is a perspective view of a sampling needle according to some embodiments of the present specification;

[0015] Fig. 9 is a schematic diagram of the structure of a sampling needle according to some embodiments of this specification;

[0016] Fig.10 is a schematic diagram of the structure of the biopsy sampling box and the sterile adapter before installation according to some embodiments of this specification;

[0017] Fig.11 It is a schematic diagram of the structure of the biopsy sampling box and the sterile adapter when they are installed according to some embodiments of this specification.

[0018] Reference numerals: biopsy sampling box 100; box body 110; liquid containing chamber 111; needle hole 112; cleaning component 120; cleaning end 121; connecting end 122; limiting block 123; mounting nut 124; transmission mechanism 130; first gear 131; second gear 132; second fixed shaft 1321; friction transmission member 133; partition 140; first side wall 1401; top wall 1402; second side wall 1403; arc-shaped limiting hole 141; arc-shaped containing groove 142; opening 143; limiting protrusion 144; mounting hole 145; first mounting protrusion 146; positioning hole 147 ; Articulated joint 148; Abutment protrusion 149; Release button 150; Press key 151; U-leg structure 152; Pressing area 153; First fixing hole 160; Sampling needle 200; Coaxial needle 210; Notch 211; Biopsy needle outer sleeve 220; Biopsy needle core 230; Side groove 231; Biopsy sample 300; Biopsy instrument 400; Sterile adapter 500; Flexible buckle 510; First clamping hole 511; Second clamping hole 512; Second fixing hole 520; Support member 530; Positioning column 540; Friction fitting member 550; Second friction contact surface 551; Biopsy device 600. DETAILED DESCRIPTION

[0019] In order to more clearly illustrate the technical solutions of the embodiments of this specification, the following is a brief introduction to the drawings required for the description of the embodiments. Obviously, the drawings described below are only some examples or embodiments of this specification. For ordinary technicians in this field, this specification can also be applied to other similar scenarios based on these drawings without creative work. Unless it is obvious from the language environment or otherwise explained, the same reference numerals in the figures represent the same structure or operation.

[0020] As shown in this specification and claims, unless the context clearly indicates an exception, the words "a", "an", "an" and / or "the" do not refer to the singular and may also include the plural. Generally speaking, the terms "comprise" and "include" only indicate the inclusion of the steps and elements that have been clearly identified, and these steps and elements do not constitute an exclusive list. The method or device may also include other steps or elements.

[0021] The present specification provides a biopsy sampling box, which may include a box body and a cleaning component and a transmission mechanism arranged in the box body. The transmission mechanism may be connected to an external power device, and the cleaning component may be driven by the transmission mechanism to perform linear motion or swing. The sampling needle used to obtain the biopsy sample can be inserted into the box body through the pinhole on the box body. When the cleaning component moves, it can sweep at least a part of the area of ​​the sampling needle, so that the biopsy sample temporarily stored on the sampling needle is swept into the biopsy sampling box, and the transfer of the biopsy sample is realized. In some cases, after the sampling needle obtains the biopsy sample, the sampling needle can be directly inserted into the biopsy sampling box, and the biopsy sample on the sampling needle is swept into the biopsy sampling box through the cleaning component, shortening the distance and operation process for the doctor to transport the biopsy sample to the biopsy sampling box, and effectively improving the efficiency of biopsy sampling. In some embodiments, the biopsy sampling box can be used in conjunction with a biopsy instrument, and the biopsy instrument may include a sampling needle, and the sampling needle can be used to perform a puncture biopsy on the patient's tissue and obtain a biopsy sample. The biopsy sampling box can be used to collect biopsy samples obtained by the biopsy instrument. When the biopsy sampling box is installed on the biopsy instrument, the doctor can control the sampling needle to move along its own axis to perform multiple biopsy puncture sampling, or transfer the obtained biopsy samples to the biopsy sampling box, etc., which not only achieves the purpose of multiple biopsy sampling, but also saves the step of transferring the biopsy sample to the formalin solution reagent bottle, simplifies the operation process of biopsy sampling, and improves the operation efficiency of biopsy sampling.

[0022] In some embodiments, in combination Figure 1-Figure 2 As shown, the biopsy sampling box 100 may include a box body 110, a cleaning component 120 and a transmission mechanism 130. The transmission mechanism 130 may be disposed in the box body 110, and the transmission mechanism 130 is in transmission connection with the cleaning component 120 to drive the cleaning component 120 to swing. The box body 110 is provided with a needle hole 112, and the needle hole 112 may be used for the sampling needle 200 to pass through. The swing of the cleaning component 120 may enable the cleaning end 121 on the cleaning component 120 to sweep over at least a portion of the sampling needle 200.

[0023] In some embodiments, the sampling needle 200 can be used to perform a biopsy puncture on a patient's tissue and obtain a biopsy sample 300, and the obtained biopsy sample 300 can be temporarily stored at a specific position on the sampling needle 200. When the specific position of the sampling needle 200 is located in the biopsy sampling box 100, the biopsy sample 300 on the sampling needle 200 can be swept off by the swing of the cleaning component 120, thereby transferring the biopsy sample 300 to the biopsy sampling box 100. For more descriptions of the sampling needle 200 and the sampling needle 200 performing a biopsy puncture on a patient's tissue to obtain and temporarily store a biopsy sample, please refer to Figure 8-Figure 9 and description of its embodiments.

[0024] In some embodiments, the cleaning component 120 may include any structure that can separate the biopsy sample 300 from the sampling needle 200, such as a stick-shaped structure, a cylindrical structure, a plate-shaped structure (e.g., a scraper), a brush, etc. For example, the cleaning component 120 may be a scraper, and the scraper may remove the biopsy sample 300 on the sampling needle 200. For another example, the cleaning component 120 may be a roller. In some specific embodiments, such as Figure 1 As shown, the cleaning component 120 may be a brush, and the brush may include bristles (i.e., the cleaning end 121 of the cleaning component 120), and the bristles of the brush may clean the biopsy sample 300 on the sampling needle 200. In some embodiments, the bristles of the brush may be fixed to the brush handle by knitting or implanting. In some embodiments, the material for making the bristles may include nylon or silicone, so that the bristles are relatively soft and will not damage the biopsy sample 300 on the sampling needle 200.

[0025] In some embodiments, the biopsy sampling box 100 may further include a partition 140, which may be used to separate the transmission mechanism 130 and the sampling area for the biopsy sample 300 so that the two do not affect each other. For more details about the partition 140, please refer to the description of other embodiments of this specification.

[0026] In some embodiments, in combination Figure 1-Figure 3 As shown, a sealing structure is provided on the pinhole 112, and the area corresponding to the box body 110 and the cleaning component 120 forms a liquid holding chamber 111 with the partition 140, and the liquid holding chamber 111 can be used to hold formalin solution. As an example only, a sealing ring (not shown in the figure) is provided on the pinhole 112, and the sealing ring can seal the pinhole 112. After the partition 140 is set, the first side wall 1401 of the partition 140 can divide the internal cavity of the box body 110, a part of the cavity is used to set the transmission mechanism 130, and the other part of the cavity is used for sampling the biopsy sample 300. The area corresponding to the box body 110 and the cleaning component 120 can refer to the bottom wall and side wall of the cavity of the box body 110 that accommodates the cleaning component 120, and the bottom wall and side wall of the cavity of the box body 110 can form a cavity with the first side wall 1401 of the partition 140, which is the liquid holding chamber 111. In some embodiments, the liquid level of the liquid containing chamber 111 may be lower than the arc-shaped limiting hole 141 to avoid liquid leakage.

[0027] In some cases, the sealing ring can not only prevent the liquid in the box body 110 from leaking through the needle hole 112, but also play a role in further fixing the sampling needle 200, reducing the deflection of the sampling needle 200 caused by the force of the patient's tissue during the puncture process, and ensuring that the movement trajectory of the puncture needle always remains straight. Figure 8When the sampling needle 200 is inserted into the tissue (within the side groove 231 of the biopsy needle core 230), the sampling needle 200 will be limited by the sealing valve to reduce deviation and shaking, thereby reducing the risk of injury to the patient.

[0028] In some cases, by providing a liquid containing chamber 111 for containing formalin solution in the biopsy sampling box 100, the doctor can observe the condition of the biopsy sample 300 and decide whether further biopsy sampling is needed according to the fullness of the biopsy sample 300. Compared with the process of transferring the biopsy sample 300 to a formalin specimen bottle and then sending it for inspection, the biopsy sampling box 100 can be directly sent for inspection after the biopsy is completed, which saves steps and is convenient for the doctor's operation.

[0029] In some embodiments, the liquid containing chamber 111 is provided with a camera device (not shown in the figure) to facilitate the doctor to observe the condition of the biopsy sample 300 so as to decide whether further biopsy sampling is needed according to the fullness of the biopsy sample 300 .

[0030] In some embodiments, at least a portion of the box body 110 is made of a transparent material. For example, the portion of the box body 110 corresponding to the liquid holding chamber 111 may be transparent so that image information in the liquid holding chamber 111 can be obtained by a camera. In some embodiments, all portions of the box body 110 are made of a transparent material. In some embodiments, the material for making the box body 110 may include acrylic, polyvinyl chloride (PVC), polypropylene (PP), etc.

[0031] In some embodiments, the transmission mechanism 130 may include a gear transmission mechanism, a pulley transmission mechanism, a guide rail and slider transmission mechanism, a worm gear transmission mechanism, a crank connecting rod transmission mechanism, etc. In some embodiments, the type of the transmission mechanism 130 may be determined according to the form of movement of the cleaning component 120. For example, when the form of movement of the cleaning component 120 is swinging, the transmission mechanism 130 may be a gear transmission mechanism, a pulley transmission mechanism, etc. Swinging refers to a movement with a fixed point as the center and the other end moving back and forth in a circular arc trajectory on the same plane.

[0032] In some embodiments, Figure 1 and Figure 2As shown, the gear transmission mechanism may include a first gear 131 and a second gear 132, the first gear 131 may be transmission-connected to an external power device, the first gear 131 may mesh with the second gear 132, and the second gear 132 may be fixedly connected to the connecting end 122 of the cleaning component 120. The first gear 131 and the second gear 132 are rotatably disposed on the inner wall of the box body 110. Wherein, the connecting end 122 is used to connect the cleaning end 121 with the transmission mechanism 130. As an example only, the first gear 131 may include a first fixed shaft (not shown in the figure), the second gear 132 may include a second fixed shaft 1321, the first fixed shaft and the second fixed shaft 1321 are fixed to the inner wall of the box body 110, the first gear 131 is rotatably disposed on the first fixed shaft, and the second gear 132 is rotatably disposed on the second fixed shaft 1321.

[0033] The working principle of the biopsy sampling box 100 provided in this specification is: the first gear 131 is driven by an external power device to rotate counterclockwise or clockwise, thereby driving the second gear 132 to rotate in the opposite direction, so as to drive the cleaning component 120 to move along the circumferential direction of the second gear 132. Figure 2 As shown, when the first gear 131 moves counterclockwise (as shown by arrow Q), the second gear 132 will be driven to move clockwise (as shown by arrow P), thereby driving the cleaning component 120 to move clockwise along the circumference of the second gear 132. When the first gear 131 moves clockwise, the second gear 132 will be driven to move counterclockwise, thereby driving the cleaning component 120 to move counterclockwise along the circumference of the second gear 132. That is, by changing the movement direction of the first gear 131, the cleaning component 120 can reciprocate along the circumference of the second gear 132, thereby realizing the swing of the cleaning component 120, and the biopsy sample 300 on the sampling needle 200 is swept off by the swing of the cleaning component 120.

[0034] In some embodiments, the connection end 122 of the cleaning member 120 may be connected to the end surface of the second gear 132, for example, Figure 1 In the illustrated embodiment, the connection end 122 of the cleaning member 120 is fixedly connected to the end surface of the second gear 132. In some embodiments, the connection end 122 of the cleaning member 120 can be connected to the gear teeth or tooth grooves of the second gear 132.

[0035] In some embodiments, the swing amplitude of the cleaning component 120 may be related to the angular stroke of the second gear 132. In order to avoid excessive swing amplitude of the cleaning component 120, the rotation angle of the second gear 132 needs to be limited. In some embodiments, the maximum rotation angle of the second gear 132 may be in the range of 30 degrees to 150 degrees. In some embodiments, the maximum rotation angle of the second gear 132 may be in the range of 30 degrees to 120 degrees. In some embodiments, the maximum rotation angle of the second gear 132 may be in the range of 30 degrees to 90 degrees.

[0036] In some embodiments, a friction transmission member 133 is disposed on the rotating shaft of the first gear 131. When the biopsy sampling box 100 is installed on a biopsy instrument (for example, Figure 7 The power device of the biopsy instrument can drive the first gear 131 to rotate via the friction transmission member 133. The friction transmission member 133 refers to a structural member whose surface friction coefficient is greater than a certain threshold value, so that when the active member moves relative to the friction transmission member 133, a large friction force can be generated, and the friction force is used to drive the driven member to move. In this embodiment, the active member may refer to the power device of the biopsy instrument, and the driven member may refer to the first gear 131. As an example only, the power device of the biopsy instrument may include a rotating shaft and a driving mechanism for driving the rotating shaft to rotate. When the biopsy sampling box 100 is installed on the biopsy instrument, the biopsy sampling box 100 is located at the end of the biopsy instrument (such as Figure 7 As shown in the figure, that is, the end of the biopsy instrument close to the patient, the end of the rotating shaft of the biopsy instrument can abut against the friction transmission member 133. When the driving mechanism drives the rotating shaft to rotate, a large friction force is generated between the rotating shaft and the friction transmission member 133. Since the friction transmission member 133 is relatively fixed to the first gear 131, it can drive the first gear 131 to rotate and control the cleaning component 120 to swing. For more details about the rotating shaft, please refer to the description of other embodiments of this specification, which will not be repeated here.

[0037] In some cases, the doctor can control the movement of the cleaning component 120 on the biopsy sampling box 100 by manipulating the rotation of the rotating shaft of the biopsy instrument, without manually controlling the biopsy sampling box 100, so that multiple biopsy sampling can be performed more quickly and efficiently, thereby improving the efficiency of biopsy sampling. In addition, since the friction transmission member 133 drives the first gear 131 to rotate by the friction force generated by the rotating shaft, during the installation of the biopsy instrument and the biopsy sampling box 100, it is only necessary to abut the rotating shaft with the friction transmission member 133 to achieve the transmission connection between the rotating shaft and the first gear 131, and it is not necessary to set up other power transmission devices between the power device and the friction transmission member 133, which not only reduces the equipment cost, but also reduces the difficulty of installing the biopsy instrument and the biopsy sampling box 100, and simplifies the installation steps.

[0038] In some embodiments, the friction transmission member 133 may include a silicone pad, a rubber pad, a plastic pad, etc. In some embodiments, the friction transmission member 133 may be fixedly connected to the first gear 131. The fixed connection method may include bonding, integral molding, etc. In some embodiments, the friction transmission member 133 may be detachably connected to the first gear 131. The detachable connection method may include a screw nut connection, a snap connection, a magnetic connection, etc.

[0039] It should be noted that Figure 1-Figure 2 The examples of the transmission mechanism 130 are for illustration purposes only and are not intended to limit the specific structure of the transmission mechanism 130. In some embodiments, the transmission mechanism 130 may include only the first gear 131, the end surface of the first gear 131 is provided with a friction transmission member 133, and the connecting end 122 of the cleaning component 120 may be fixedly connected to the first gear 131, that is, the first gear 131 is driven to rotate by the rotating shaft, and the cleaning component 120 is directly driven to swing by the first gear 131, and there is no need to additionally provide a second gear 132 between the first gear 131 and the cleaning component 120.

[0040] In some embodiments, the movement of the cleaning component 120 may also include linear reciprocating motion. For example, the cleaning component 120 may reciprocate in the width direction or length direction of the biopsy sampling box 100, as long as the cleaning end 121 of the cleaning component 120 can sweep the biopsy sample 300 on the sampling needle 200. Figure 1 As indicated by the arrow Y in the figure, the length direction of the biopsy sampling box 100 can be Figure 1 As indicated by the arrow X in FIG. 1 , the height direction of the biopsy sampling box 100 can be Figure 1 Indicated by the arrow Z in the figure. In some embodiments, when the movement form of the cleaning component 120 is a linear reciprocating motion, the transmission mechanism 130 may include a pulley transmission mechanism. As an example only, the pulley transmission mechanism (not shown in the figure) may include a first transmission wheel, a second transmission wheel and a conveyor belt that cooperates with the first transmission wheel and the second transmission wheel, at least a portion of the conveyor belt is parallel to the width direction of the biopsy sampling box 100, and the connecting end 122 of the cleaning component 120 is fixedly connected to the part of the transmission belt, and a friction transmission member 133 is provided on the first transmission wheel. When the power device of the biopsy instrument drives the first transmission wheel to rotate counterclockwise or counterclockwise, the first transmission wheel can drive the conveyor belt for transportation, thereby driving the cleaning component 120 to reciprocate along the width direction of the biopsy sampling box 100.

[0041] In some embodiments, in combination Figure 1-Figure 3As shown, the partition 140 can be covered outside the transmission mechanism 130, and the first side wall 1401 of the partition 140 near the pinhole 112 is provided with an arc-shaped limit hole 141, and the connection end 122 of the cleaning component 120 is provided with a limit block 123, and the connection end 122 passes through the arc-shaped limit hole 141 and is transmission-connected with the transmission mechanism 130, and the limit block 123 cooperates with the arc-shaped limit hole 141 to limit the swing position of the cleaning component 120. As an example only, the partition 140 may include a first side wall 1401 near the pinhole 112 and a top wall 1402 located above the transmission mechanism 130, and the first side wall 1401 may be connected to the top wall 1402. The first side wall 1401 of the partition 140 close to the pinhole 112 may be arc-shaped, and the center of the circle where the arc-shaped first side wall 1401 is located may overlap or approximately overlap with the center of the second gear 132. The stopper 123 may be arranged on the side of the connection end 122 close to the cleaning end 121, and the stopper 123 extends along the height direction of the biopsy sampling box 100, and in the height direction of the biopsy sampling box 100, the size of the stopper 123 is larger than the size of the arc-shaped stopper hole 141. The end of the connection end 122 away from the cleaning end 121 can pass through the arc-shaped stopper hole 141 to connect with the second gear 132, and the stopper 123 abuts against the side wall of the arc-shaped stopper hole 141.

[0042] In some cases, during the swinging of the cleaning component 120, since the arc-shaped limiting hole 141 is provided, when the connecting end 122 moves to a position in contact with both ends of the arc-shaped limiting hole 141 in the arc length direction, the arc-shaped limiting hole 141 can block the connecting end 122 to limit the cleaning component 120 from continuing to swing, thereby limiting the swinging position of the cleaning component 120. In addition, since the limiting block 123 is provided, it can be ensured that the cleaning end 121 and the second gear 132 remain relatively still, so that the center of the circle where the swinging path of the cleaning end 121 is located can overlap or approximately overlap with the center of the second gear 132, thereby ensuring the accuracy of the cleaning end 121 during the swinging process.

[0043] In some embodiments, the surface of the limit block 123 in contact with the arc-shaped limit hole 141 has a certain curvature, so that the limit block 123 can fit tightly with the side wall of the arc-shaped limit hole 141, thereby improving the accuracy of the cleaning end 121 during the swinging process.

[0044] In some embodiments, in combination Figure 1 and Figure 3 As shown, the partition 140 is further provided with an arc-shaped receiving groove 142 . When the connecting end 122 is fixedly connected to the second gear 132 via the mounting nut 124 , the arc-shaped receiving groove 142 can be used to accommodate the mounting nut 124 , thereby further limiting the swing of the cleaning component 120 .

[0045] In some embodiments, in combination Figure 4-Figure 6As shown, a limiting protrusion 144 is provided on the inner side of the partition 140, when the biopsy sampling box 100 is not installed on the biopsy instrument (for example, Figure 7 When the biopsy instrument 400 is mounted on the first gear 131, the limiting protrusion 144 is inserted into the tooth gap of the first gear 131 to limit the rotation of the first gear 131.

[0046] In some cases, the stop protrusion 144 can limit the rotation of the first gear 131 before the biopsy sampling box 100 is installed with the biopsy instrument, so that the cleaning component (e.g., Figure 1 The position of the cleaning component 120) in the biopsy sampling box is fixed and will not change during the transportation and installation of the biopsy sampling box 100, ensuring that the initial position of the cleaning component of the biopsy sampling box 100 is consistent with that of the biopsy instrument after installation.

[0047] In some embodiments, the partition 140 is provided with an opening 143 at a position corresponding to the friction transmission member 133. The inner diameter of the opening 143 is larger than the outer diameter of the friction transmission member 133 and smaller than the outer diameter of the first gear 131. The opening 143 can facilitate the friction transmission member 133 to abut against a power device (e.g., a rotating shaft). When the biopsy sampling box 100 is not installed on the biopsy instrument, the friction transmission member 133 corresponds to the first gear 131. When the biopsy sampling box 100 is installed on the biopsy instrument, the friction transmission member 133 corresponds to the limiting protrusion 144. The correspondence between the friction transmission member 133 and the limiting protrusion 144 means that in the height direction of the biopsy sampling box 100, the projection of the friction transmission member 133 and the projection of the limiting protrusion 144 at least partially overlap. The correspondence between the first gear 131 and the limiting protrusion 144 means that in the height direction (e.g., Figure 4 The projection of the first gear 131 at least partially overlaps with the projection of the limiting protrusion 144. Figure 4 and Figure 5 As shown, the biopsy sampling box 100 is not installed on the biopsy instrument. At this time, the projection of the upper limit protrusion 144 in the height direction of the biopsy sampling box 100 completely overlaps with the projection of the first gear 131, that is, the limit protrusion 144 is inserted into the tooth gap of the first gear 131, limiting the rotation of the first gear 131. In another example, Figure 6 As shown, the biopsy sampling box 100 is installed on a biopsy instrument (not shown in the figure), and the rotating shaft of the biopsy instrument abuts against the friction transmission member 133, so that the friction transmission member 133 and the first gear 131 move to the right along the height direction of the biopsy sampling box 100, thereby separating the limiting protrusion 144 from the first gear 131, and making the friction transmission member 133 correspond to the limiting protrusion 144. When the first gear 131 is freed from the restriction of the limiting protrusion 144, it can rotate driven by the rotating shaft.

[0048] In some embodiments, the shape of the limiting protrusion 144 may include a regular or irregular shape such as a cylinder, a prism, a sphere, a hemisphere, etc. Figure 3 In the illustrated embodiment, the limiting protrusion 144 is a plate-shaped protrusion disposed on the partition 140, and the plate-shaped protrusion has a tip. When the biopsy sampling box 100 is not installed on the biopsy instrument, the tip of the plate-shaped protrusion can just extend into the tooth gap of the first gear 131. In another example, the limiting protrusion 144 can be a limiting cylinder, and when the biopsy sampling box 100 is installed on the biopsy instrument, the limiting cylinder is separated from the first gear 131. When the biopsy sampling box 100 is not installed on the biopsy instrument, the limiting cylinder can extend into the tooth gap of the first gear 131.

[0049] In some embodiments, the partition 140 can be detachably connected to the box body 110 of the biopsy sampling box 100. Exemplary detachable connection methods may include magnetic connection, snap connection, screw nut connection, hinge connection, etc. This specification will take hinge connection as an example for description. Figure 1 and Figure 4 As shown, hinged joints 148 are also provided on the two side walls (or referred to as second side walls 1403) along the width direction of the partition 140. The hinged joints 148 can be adapted to the U-shaped leg structure 152 provided on the side wall of the box body 110. Both the hinged joints 148 and the U-shaped leg structure 152 are provided with pin holes. When the box body 110 is matched with the partition 140, the hinged joint 148 can extend into the gap of the U-shaped leg structure 152, and the pin shaft (not shown in the figure) passes through the pin holes of the U-shaped leg structure 152 and the hinged joint 148, so that the U-shaped leg structure 152 and the hinged joint 148 can be rotatably connected. For more details about the U-shaped leg structure 152, please refer to Figure 10-11 In some embodiments, the partition 140 may be fixedly connected to the box body 110. The fixed connection method may include bonding, welding, etc.

[0050] In some embodiments, the box body 110 of the biopsy sampling box 100 is provided with a first fixing hole (eg, Figure 1 In some embodiments, the first fixing hole 160 is provided in the box body 110 and the partition 140. Before installing the partition 140, the box body 110 and the partition 140 can be fixed by the cooperation of the bolt and the first fixing hole. In some embodiments, the first fixing hole can be provided on the partition 140. In some embodiments, the first fixing hole is not necessary, and the box body 110 and the partition 140 can be fixed by gluing, snap connection, magnetic connection, etc.

[0051] like Figure 7As shown, the present specification provides a biopsy device 600, which includes a biopsy instrument 400 and a biopsy sampling box 100 in the above-mentioned embodiment, and the biopsy sampling box 100 is installed on the biopsy instrument 400. The biopsy instrument 400 is used to obtain a biopsy sample (for example, Figure 2 The biopsy sample shown in the figure) is used to collect the biopsy sample obtained by the biopsy instrument 400.

[0052] In some embodiments, in combination Figure 7-Figure 9 As shown, the biopsy instrument 400 may include a sampling needle 200, and the sampling needle 200 may include a coaxial needle 210, a biopsy needle outer sleeve 220, and a biopsy needle core 230. The coaxial needle 210, the biopsy needle outer sleeve 220, and the biopsy needle core 230 are coaxially sleeved in sequence. The biopsy needle core 230 is provided with a side groove 231, and the coaxial needle 210 is provided with a notch 211 matching the side groove 231. When the biopsy sampling box 100 is installed on the biopsy instrument 400, the notch 211 corresponds to the position of the cleaning end 121 of the cleaning component 120.

[0053] The coaxial needle 210, the biopsy needle outer sleeve 220 and the biopsy needle core 230 are sequentially coaxially sheathed, which means that the sheathing is performed from the outside to the inside, that is, the coaxial needle 210 is first sheathed outside the biopsy needle outer sleeve 220, and then the biopsy needle outer sleeve 220 and the coaxial needle 210 are sheathed outside the biopsy needle core 230. Figure 8 and Fig. 9 As shown. By controlling the coaxial needle 210, the biopsy needle outer sleeve 220 and the biopsy needle core 230 to move along the axial direction of the sampling needle 200, the coaxial needle 210, the biopsy needle outer sleeve 220 and the biopsy needle core 230 cooperate to achieve biopsy sampling. The tip (or distal end) of the biopsy needle core 230 can play a role in puncturing tissue, and the tip of the coaxial needle 210 and the biopsy needle outer sleeve 220 can play a role in cutting tissue. The tip (or distal end) can refer to the end away from the surgical operator (such as a doctor) or the end close to the patient. When a biopsy is required, the coaxial needle 210, the biopsy needle outer sleeve 220 and the biopsy needle core 230 need to be moved to the vicinity of the lesion site first, the coaxial needle 210 is used to establish a puncture channel, and then the biopsy needle core 230 is controlled to insert the needle into the patient's tissue, and the biopsy sampling is performed through the side groove 231 of the biopsy needle core 230. Then, the biopsy needle outer sleeve 220 is controlled to penetrate the patient's tissue, the tissue in the side groove 231 is cut and retained in the side groove 231 to complete the biopsy puncture, and finally the coaxial needle 210, the biopsy needle outer sleeve 220 and the biopsy needle core 230 are retracted into the biopsy sampling box 100, and the biopsy sample 300 is exposed to the biopsy sampling box (for example, through the notch 211 of the coaxial needle 210). Figure 1 In the biopsy sampling box 100), by cleaning components (e.g., Figure 1The cleaning component 120 in the side groove 231 sweeps the biopsy sample 300 into the biopsy sampling box. In addition, since the biopsy needle outer sleeve 220 and the biopsy needle core 230 are not completely withdrawn from the coaxial needle 210 at this time, no air will enter the human body through the notch 211 of the coaxial needle 210, thereby reducing the incidence of pneumothorax caused by the sampling process.

[0054] In some embodiments, in combination Fig.10 and Fig.11 As shown, the biopsy device 600 may also include a sterile adapter 500, a biopsy instrument (e.g., Figure 7 The biopsy instrument 400 in the apparatus can be connected to the biopsy sampling box 100 through a sterile adapter 500. The sterile adapter 500 can be used to isolate the biopsy instrument from the biopsy sampling box 100 to ensure that the biopsy instrument is not contaminated by organisms.

[0055] In some embodiments, the biopsy instrument and the sterile adapter 500, the biopsy sampling box 100 and the sterile adapter 500 can be matched through a physical interface. Exemplary physical interfaces may include snap-on connection components, socket-and-socket components, magnetic connection components, etc. Fig.10 and Fig.11As shown, the sterile adapter 500 is provided with two flexible buckles 510 and two second fixing holes 520. The two flexible buckles 510 respectively penetrate the two second fixing holes 520, and the flexible buckles 510 are fixed in the second fixing holes 520 by the support member 530. The flexible buckles 510 can rotate around the connection with the support member 530. A first clamping hole 511 is provided at the first end of the flexible buckle 510. The side wall of the box body 110 of the biopsy sampling box 100 and the second side wall 1403 of the partition 140 define two mounting holes 145, and the positions of the two mounting holes 145 correspond to the positions of the two flexible buckles 510, wherein a first mounting protrusion 146 is provided on the second side wall 1403 of the partition 140 in the mounting hole 145, and the first mounting protrusion 146 is adapted to the first clamping hole 511. It should be noted that before installing the sterile adapter 500 and the biopsy sampling box 100, the sterile adapter 500 needs to be installed with the biopsy instrument, for example, the second end of the flexible buckle 510 needs to be matched with the second mounting protrusion on the biopsy instrument. At this time, the second end of the flexible buckle 510 expands outward (i.e., in the direction away from the other flexible buckle 510), and the first end of the flexible buckle 510 closes inward (i.e., in the direction close to the other flexible buckle 510). Since the flexible buckle 510 has a certain elasticity, when the first end of the flexible buckle 510 contacts the first mounting protrusion 146, the first end of the flexible buckle 510 can overcome the elastic force and expand outward (i.e., in the direction away from the other flexible buckle 510) until the first mounting protrusion 146 can be snapped into the first snap hole 511. At this time, the flexible buckle 510 can be firmly snapped on the first mounting protrusion 146 under the action of the elastic force, thereby achieving fixation.

[0056] In some embodiments, the side wall of the first mounting protrusion 146 close to the sterile adapter 500 may form an angle greater than 90 degrees and less than 180 degrees with the second side wall 1403 of the partition 140, that is, the first mounting protrusion 146 is provided with an inclined side wall on the side close to the sterile adapter 500. When the first end of the flexible buckle 510 abuts against the first mounting protrusion 146, the inclined side wall of the first mounting protrusion 146 may make it easier for the first end of the flexible buckle 510 to expand and deform outward, thereby increasing the distance between the first ends of the two flexible buckles 510, so that the first clamping hole 511 of the flexible buckle 510 can be more smoothly buckled on the first mounting protrusion 146.

[0057] In some embodiments, Fig.10As shown, at least two positioning holes 147 are provided on the partition 140 of the biopsy sampling box 100, and at least two positioning posts 540 adapted to the positioning holes 147 are provided on the sterile adapter 500. Before installing the sterile adapter 500 and the biopsy sampling box 100, the positioning posts 540 can be inserted into the positioning holes 147 to position the installation positions of the biopsy sampling box 100 and the sterile adapter 500, thereby improving the installation accuracy.

[0058] In some embodiments, a friction fitting member 550 is provided at a position corresponding to the friction transmission member 133 on the sterile adapter 500, and the friction fitting member 550 includes a first friction contact surface (not shown) and a second friction contact surface 551. When the sterile adapter 500 is mated with the biopsy sampling box 100, the first friction contact surface abuts against the friction transmission member 133. When the sterile adapter 500 is mated with the biopsy instrument, the second friction contact surface 551 abuts against the power device (e.g., rotating shaft) of the biopsy instrument.

[0059] In some cases, by providing the friction fitting 550, it is possible to avoid direct contact between the power device of the biopsy instrument and the friction transmission member 133, and at the same time, the rotation of the friction transmission member 133 can be controlled by the power device of the biopsy instrument.

[0060] In some embodiments, the biopsy sampling box 100 further includes a release button 150. When the release button 150 is pressed, the flexible buckle 510 can be separated from the first mounting protrusion 146, thereby facilitating the disassembly of the biopsy sampling box 100 and the sterile adapter 500. Figure 1 , Figure 4 and Fig.11 As shown, the side wall of the box body 110 is provided with a through hole (not shown in the figure), and the release button 150 may include a rotating shaft (not shown in the figure), a pressing key 151, and a U-shaped leg structure 152 fixedly connected to the pressing key 151. The rotating shaft can be fixed in the circular hole of the hinged joint 148, and the axial direction of the rotating shaft is parallel to the height direction of the biopsy sampling box 100. The angle between the plane where the pressing key 151 is located and the plane where the U-shaped leg structure 152 is located is greater than 90 degrees and less than 180 degrees, and it is rotatably arranged on the rotating shaft. A pressing area 153 is provided on the pressing key 151, and the pressing area 153 can extend out of the box body 110 through the through hole. An abutting protrusion 149 is provided at a position of the partition 140 corresponding to the pressing key 151, and a compression spring (not shown in the figure) is provided between the abutting protrusion 149 and the pressing area 153. When the pressing area 153 is not pressed (such as Fig.11 As shown), the key 151 is in the initial state. When the key 151 is in the initial state, Figure 1As shown, the U-shaped leg structure 152 is attached to the side wall of the box body 110, and the U-shaped leg structure 152 does not abut against the flexible buckle 510 or the force applied by the U-shaped leg structure 152 to the flexible buckle 510 cannot make the flexible buckle 510 detach from the first mounting protrusion 146. When the pressing area 153 is pressed, the compression spring is compressed, and the U-shaped leg structure 152 rotates toward the flexible buckle 510, thereby pushing the flexible buckle 510 to move. When the operator removes the external force, the pressing key 151 can rebound to the initial state due to the compression spring. When the pressing key 151 is pressed to a certain position, the U-shaped leg structure 152 can push the flexible buckle 510 away from the first mounting protrusion 146, so that the biopsy sampling box 100 and the sterile adapter 500 can be disassembled.

[0061] In some embodiments, Fig.10 As shown, the second end of the flexible clip 510 is provided with a second clip hole 512, and the biopsy instrument is provided with a second mounting protrusion (not shown in the figure) adapted to the second clip hole 512. When the second clip hole 512 is snapped onto the second mounting protrusion, the biopsy instrument can be firmly mounted together with the sterile adapter 500.

[0062] In some embodiments, during the installation process, the sterile adapter 500 can be first connected to the biopsy instrument through the second clamping hole 512 and the second mounting protrusion, and then the sterile adapter 500 can be connected to the biopsy sampling box 100 using the first clamping hole 511 and the first mounting protrusion 146. As an example only, the first ends of the two flexible buckles 510 can be manually pressed and gradually closed to increase the distance between the second ends of the two flexible buckles 510 until the second clamping hole 512 can be engaged with the second mounting protrusion. After the sterile adapter 500 and the biopsy instrument are installed, the first end of the flexible buckle 510 is inserted into the mounting hole 145 and engaged with the first mounting protrusion 146. Similarly, in some embodiments, when disassembling the biopsy device 600, the biopsy sampling box 100 can be disassembled from the sterile adapter 500 by releasing the button 150, and then the first ends of the two flexible buckles 510 are pressed and gradually closed to separate the second clamping hole 512 from the second mounting protrusion of the biopsy instrument, thereby disassembling the biopsy instrument from the sterile adapter 500. In some embodiments, during the installation process, the sterile adapter 500 can be first connected to the biopsy sampling box 100 through the first clamping hole 511 and the first mounting protrusion 146, and then the sterile adapter 500 can be connected to the biopsy instrument by using the second clamping hole 512 and the second mounting protrusion.

[0063] The process of performing biopsy puncture sampling using the biopsy device provided in this specification may include the following steps: first, the biopsy instrument and the biopsy sampling box are installed and fixed by a sterile adapter, so that the rotating shaft of the biopsy instrument abuts against the friction transmission part of the biopsy sampling box, and the sampling needle of the biopsy instrument passes through the needle hole of the biopsy sampling box. The patient's tissue is biopsied by controlling the movement of the sampling needle, and the biopsy sample is temporarily stored in the side groove of the biopsy needle core. After the biopsy puncture is completed, the sampling needle is controlled to move so that the notch of the coaxial needle of the sampling needle and the side groove of the biopsy needle core are located in the biopsy sampling box. The cleaning component of the biopsy sampling box is driven to move by controlling the rotating shaft of the biopsy instrument, and the biopsy sample in the side groove of the biopsy needle core is swept into the liquid containing chamber of the biopsy sampling box, thereby transferring the biopsy sample to the formalin solution. After the transfer of the biopsy sample is completed, the biopsy sampling box can be removed and the biopsy sampling box can be sent for inspection.

[0064] The beneficial effects of the biopsy sampling box and biopsy device provided in this specification may include but are not limited to: (1) by setting up the biopsy sampling box, after the sampling needle obtains the biopsy sample, the sampling needle can be directly inserted into the biopsy sampling box, and the biopsy sample on the sampling needle can be swept into the biopsy sampling box by the cleaning component, thereby shortening the distance and operation process for the doctor to transport the biopsy sample to the biopsy sampling box, and effectively improving the efficiency of biopsy sampling; (2) after the biopsy sampling box is matched with the biopsy instrument, the doctor can control the sampling needle to move along its own axis to perform multiple biopsy puncture sampling, or transfer the obtained biopsy sample to the biopsy sampling box, etc., which not only realizes The purpose of multiple biopsy sampling is achieved, and the step of transferring the biopsy sample to the formalin solution reagent bottle is omitted, the operation process of biopsy sampling is simplified, and the operation efficiency of biopsy sampling is improved; (3) by setting a sealing valve on the needle hole, it can prevent the liquid in the box from leaking from the needle hole, and it can also play a role in further fixing the sampling needle, reducing the deflection of the sampling needle caused by the force of the patient's tissue during the puncture process, ensuring that the movement trajectory of the puncture needle always remains in a straight line. In addition, when the cleaning component cleans the tissue in the sampling needle, the sampling needle will also be limited by the sealing valve to reduce the deviation and shaking, thereby reducing the risk of injury to the patient; (4 ) By setting a friction transmission part, the doctor can control the movement of the cleaning component on the biopsy sampling box by manipulating the rotation of the rotating shaft of the biopsy instrument, without manually controlling the biopsy sampling box, so that multiple biopsy sampling can be performed more quickly and efficiently, thereby improving the efficiency of biopsy sampling. In addition, since the friction transmission part drives the first gear to rotate by the friction force generated by the rotating shaft, during the installation of the biopsy instrument and the biopsy sampling box, it is only necessary to abut the rotating shaft with the friction transmission part to achieve the transmission connection between the rotating shaft and the first gear, and there is no need to set up other power transmission devices between the power device and the friction transmission part, which not only reduces the equipment cost, but also The difficulty of installing the biopsy instrument and the biopsy sampling box is reduced, and the installation steps are simplified; (5) by setting an arc-shaped limit hole on the partition, during the swinging process of the cleaning component, when the connecting end moves to the position in contact with the two ends of the arc-shaped limit hole in the arc length direction, the arc-shaped limit hole can block the cleaning component to limit the cleaning component from continuing to swing, thereby limiting the swinging position of the cleaning component. In addition, since the limit block is set, it can be ensured that the cleaning end and the second gear remain relatively still, so that the center of the circle where the swinging path of the cleaning end is located can overlap or approximately overlap with the center of the second gear, thereby ensuring the accuracy of the swinging process of the cleaning end.

[0065] The above description is only a preferred embodiment of this specification and is not intended to limit this specification. Any modifications, equivalent substitutions and improvements made within the spirit and principles of this specification should be included in the protection scope of this specification.

Claims

1. A biopsy sampling box (100), characterized in that: It comprises a box body (110), a cleaning component (120) and a transmission mechanism (130); The transmission mechanism (130) is disposed in the box body (110), and the transmission mechanism (130) is in transmission connection with the cleaning component (120) so as to drive the cleaning component (120) to swing; The box body (110) is provided with a pinhole (112) for allowing a sampling needle (200) to pass through, and the swing of the cleaning component (120) enables the cleaning end (121) of the cleaning component (120) to sweep over at least a partial area of ​​the sampling needle (200).

2. The biopsy sampling box (100) according to claim 1, characterized in that: The invention also comprises a partition plate (140), wherein the partition plate (140) is covered outside the transmission mechanism (130), and an arc-shaped limiting hole (141) is provided on the first side wall (1401) of the partition plate (140) close to the needle hole (112); a limiting block (123) is provided at the connecting end (122) of the cleaning component (120); the connecting end (122) passes through the arc-shaped limiting hole (141) and is transmission-connected to the transmission mechanism (130); the limiting block (123) cooperates with the arc-shaped limiting hole (141) to limit the swinging position of the cleaning component (120).

3. The biopsy sampling box (100) according to claim 2, characterized in that: The transmission mechanism (130) comprises a first gear (131) and a second gear (132); the first gear (131) is transmission-connected to an external power device; the first gear (131) is meshed with the second gear (132); and the second gear (132) is fixedly connected to the connection end (122) of the cleaning component (120).

4. The biopsy sampling box (100) according to claim 3, characterized in that: A friction transmission member (133) is provided on the rotating shaft of the first gear (131). When the biopsy sampling box (100) is installed on the biopsy instrument (400), the power device of the biopsy instrument (400) drives the first gear (131) to rotate through the friction transmission member (133).

5. The biopsy sampling box (100) according to claim 3, characterized in that: A limiting protrusion (144) is provided on the inner side of the partition (140). When the biopsy sampling box (100) is not installed on the biopsy instrument (400), the limiting protrusion (144) is inserted into the tooth gap of the first gear (131) to limit the rotation of the first gear (131).

6. The biopsy sampling box (100) according to claim 2, characterized in that: A sealing structure is provided on the pinhole (112); the box body (110) and the area corresponding to the cleaning end (121) of the cleaning component (120) and the partition plate form a liquid containing chamber (111); the liquid containing chamber (111) is used to contain a formalin solution.

7. The biopsy sampling box (100) according to claim 6, characterized in that: The liquid containing chamber (111) is provided with a camera device.

8. A biopsy device (600), characterized in that: It comprises a biopsy instrument (400) and a biopsy sampling box (100) as described in any one of claims 1 to 7; The biopsy sampling box (100) is installed on the biopsy instrument (400); the biopsy instrument (400) is used to obtain a biopsy sample (300), and the biopsy sampling box (100) is used to collect the biopsy sample (300).

9. The biopsy device (600) according to claim 8, characterized in that: The biopsy instrument (400) comprises a coaxial needle (210), a biopsy needle outer sleeve (220) and a biopsy needle core (230), wherein the coaxial needle (210), the biopsy needle outer sleeve (220) and the biopsy needle core (230) are coaxially sleeved in sequence; The biopsy needle core (230) is provided with a side groove (231), and the coaxial needle (210) is provided with a notch (211) matching the side groove (231); When the biopsy sampling box (100) is installed on the biopsy instrument (400), the notch (211) corresponds to the position of the cleaning end (121) of the cleaning component (120).

10. The biopsy device (600) according to claim 1, characterized in that: It also includes a sterile adapter (500), and the biopsy instrument (400) is connected to the biopsy sampling box (100) through the sterile adapter (500).

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