A dissection composition for minimally invasive digestive endoscopy

Abstract

This invention discloses a dissection composition for minimally invasive endoscopic surgery. By weight, the dissection composition comprises 5-10 parts of a tissue dissector, 0.5-1.0 parts of an osmotic pressure regulator, 0.01-0.2 parts of an synergist, 0.01-0.1 parts of a stabilizer, 0.001-0.1 parts of a hemostatic agent, and 0.0005-0.002 parts of a color indicator. This invention can reduce the time required for electrocautery dissection by dissolving submucosal connective tissue, thereby reducing the difficulty of surgical dissection, shortening the operation time, and lowering the risk of bleeding and perforation during and after surgery, as well as delayed bleeding and perforation, thus improving safety.

Description

Technical Field

[0001] This invention belongs to the field of medical technology, specifically relating to a dissection composition for minimally invasive digestive endoscopy. Background Technology

[0002] In recent years, with the rapid development of digestive endoscopy technology, minimally invasive endoscopic surgery has been widely used in the treatment of many diseases in clinical practice. In current clinical procedures, the main approach is to inject lifting fluid to ensure sufficient exposure of the submucosal layer, then use a distal device to allow the endoscope to enter the submucosal space, and finally use an electrocautery knife to remove the submucosal layer and diseased tissue. However, during the procedure, the need to separate the connective tissue surrounding the diseased tissue can easily lead to complications such as bleeding and perforation. Therefore, there is a need to provide a dissection composition for minimally invasive digestive endoscopic surgery. Summary of the Invention

[0003] The purpose of this invention is to provide a dissection composition for minimally invasive endoscopic surgery of the digestive system, which can reduce the time required for dissection using an electrocautery knife by dissolving submucosal connective tissue, thereby reducing the difficulty of surgical dissection, shortening the operation time, and reducing the risk of bleeding and perforation during the operation as well as delayed bleeding and perforation after the operation, thus improving safety.

[0004] To achieve the above objectives, the present invention adopts the following technical solution:

[0005] A dissection composition for minimally invasive endoscopic surgery, comprising, by weight, 5-10 parts of tissue dissector, 0.5-1.0 parts of osmotic pressure regulator, 0.01-0.2 parts of synergist, 0.01-0.1 parts of stabilizer, 0.001-0.1 parts of hemostatic agent, and 0.0005-0.002 parts of color indicator.

[0006] Furthermore, the tissue stripping agent is acetylcysteine.

[0007] Furthermore, the osmotic pressure regulator is sodium chloride.

[0008] Furthermore, the synergist is fibrinolytic enzyme.

[0009] Furthermore, the stabilizer is at least one of calcium chloride and propylene glycol.

[0010] Furthermore, the hemostatic agent is at least one of adrenaline and noradrenaline.

[0011] Furthermore, the color indicator is methylene blue.

[0012] The significant advantages of this invention are:

[0013] (1) The dissection composition for minimally invasive endoscopic surgery provided by the present invention, through the combination of acetylcysteine ​​and fibrinolytic enzyme, can synergistically enhance the dissolution of submucosal connective tissue, producing a blunt dissection effect. This results in good wound visibility, more effective vascular pretreatment, reduced risk of intraoperative bleeding, and shorter intraoperative hemostasis time. Furthermore, submucosal dissection is less likely to damage the muscle layer, reducing the probability of intraoperative perforation. At the same time, it can reduce the time spent using an electrocautery knife, reducing thermal damage, lowering the risk of delayed postoperative bleeding and perforation, and also reducing the occurrence of complications such as electrocoagulation syndrome. Therefore, using the dissection composition of the present invention can reduce the difficulty of surgical dissection and shorten the operation time.

[0014] (2) The present invention adds a color indicator to the stripping composition, which can clearly indicate the surgical range, facilitate the stripping of lesions, and reduce the risk of damaging normal tissue.

[0015] (3) The components in the dissection composition for minimally invasive digestive endoscopy provided by the present invention have good biocompatibility, which can ensure the safety of patients. Detailed Implementation

[0016] A dissection composition for minimally invasive endoscopic surgery, comprising, by weight, 5-10 parts of acetylcysteine ​​as a tissue dissector, 0.5-1.0 parts of sodium chloride as an osmotic pressure regulator, 0.01-0.2 parts of fibrinolytic enzyme as an synergist, 0.01-0.1 parts of a stabilizer, 0.001-0.1 parts of a hemostatic agent, and 0.0005-0.002 parts of methylene blue as a color indicator.

[0017] The stabilizer is at least one of calcium chloride and propylene glycol.

[0018] The hemostatic agent is at least one of adrenaline and noradrenaline.

[0019] To make the content of this invention easier to understand, the technical solution of this invention will be further described below with reference to specific embodiments, but this invention is not limited thereto. Example

[0020] 1. Experimental animals: 70 pigs, weighing 32-36 kg, were inspected and quarantined as experimental animals. Two days before the experiment, the pigs were stopped from being fed solid food and were fed sugary liquid food and water.

[0021] 2. Test reagents: Prepare the corresponding stripping compositions according to the formulas in Table 1.

[0022] Table 1. Test reagent formulation

[0023]

[0024] 3. Test methods:

[0025] Seventy pigs were randomly divided into seven groups: experimental group 1, experimental group 2, experimental group 3, experimental group 4, experimental group 5, control group 1, and control group 2, with ten pigs in each group. Each pig underwent endoscopic submucosal dissection (ESD) at three sites in the digestive tract, namely the esophagus, stomach, and intestine. The resection size at each surgical site was approximately 2cm × 2cm.

[0026] 4. Experimental Procedure:

[0027] 1) Mark

[0028] After determining the surgical site, an electrocautery mark is made at the surgical site using an electrosurgical knife.

[0029] 2) Submucosal injection

[0030] Multiple submucosal injections were performed at the outer edge of the surgical site using the corresponding test drug to lift the lesion and separate it from the muscle layer.

[0031] 3) Cut open

[0032] Use an electric cutter to cut the mucosa along the outer edge of the marked point.

[0033] 4) Submucosal connective tissue separation

[0034] The submucosal connective tissue is separated using an electrosurgical unit. The injected fluid will be gradually absorbed over time (submucosal injections can be repeated if necessary to maintain adequate mucosal elevation).

[0035] 5) Management of intraoperative bleeding

[0036] Intraoperative bleeding can be stopped by electrocautery with an electrosurgical knife or by hemostatic forceps.

[0037] 6) Postoperative wound care

[0038] After the surgery, any visible bleeding points on the wound were treated with electrocoagulation to stop the bleeding.

[0039] 5. Evaluation indicators of the experiment

[0040] (1) Separation time of submucosal connective tissue;

[0041] (2) Number of hemostasis attempts during submucosal connective tissue separation;

[0042] (3) Number of injections and dosage of samples in the control group and the experimental group during the separation of submucosal connective tissue.

[0043] 6. Test Results

[0044] Table 2

[0045]

[0046] Table 2 shows that the dissecting composition containing acetylcysteine ​​and fibrinolytic enzymes resulted in significantly less submucosal connective tissue separation time during endoscopic minimally invasive surgery compared to the composition containing only acetylcysteine. This clearly demonstrates that the dissecting composition containing fibrinolytic enzymes can improve the efficiency of endoscopic minimally invasive surgery and reduce the number of hemostasis attempts, injections, and dosages required during submucosal connective tissue separation. Furthermore, the use of hemostatic agents and osmotic pressure regulators further enhances the efficiency of endoscopic minimally invasive surgery and shortens the operation time.

[0047] The above description is only a preferred embodiment of the present invention. All equivalent changes and modifications made within the scope of the claims of the present invention should be included in the scope of the present invention.

Claims

1. A dissection composition for minimally invasive endoscopic surgery, characterized in that, The composition and dosage of the stripping composition by weight are as follows: 5-10 parts tissue stripper, 0.5-1.0 parts osmotic pressure regulator, 0.01-0.2 parts synergist, 0.01-0.1 parts stabilizer, 0.001-0.1 parts hemostatic agent, and 0.0005-0.002 parts color indicator; The tissue stripping agent is acetylcysteine; The osmotic pressure regulator is sodium chloride; The synergist is fibrinolytic enzyme; The stabilizer is composed of calcium chloride and propylene glycol in a mass ratio of 1:5; The hemostatic agent is adrenaline; The color indicator is methylene blue.

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