Backflow control device, method and equipment, readable medium and ventricular assist system

Abstract

The embodiment of the invention discloses a reflux control device, method and equipment for a ventricular assist system, a readable medium and the ventricular assist system. The reflux control device comprises an anti-reflux speed obtaining module and a rotating speed control module, and the anti-reflux speed obtaining module can obtain a target anti-reflux speed according to the current anti-reflux speed; and the rotating speed control module can generate a rotating speed control instruction according to the target rotating speed and the target anti-backflow rotating speed, and issues the rotating speed control instruction to an execution mechanism so as to control the backflow degree. According to the scheme, the effect of controlling or reducing reflux can be achieved.

Description

Technical Field

[0001] This specification relates to the field of blockchain technology, and in particular to a reflux control device, method, equipment, readable medium and ventricular assist system for a ventricular assist system. Background Art

[0002] Usually, the catheter pump of the ventricular assist system is implanted between the artery and the ventricle. Since the arterial pressure changes periodically, the aortic valve also opens and closes periodically. The closure of the aortic valve corresponds to the stage when the arterial pressure is higher than the ventricular pressure; the opening of the aortic valve corresponds to the stage when the arterial pressure is lower than the ventricular pressure. However, due to the implantation position of the catheter pump, the aortic valve may not close completely, so that there is a passage from the artery to the ventricle for blood flow, forming aortic valve regurgitation, which causes certain structural damage to the aortic valve itself.

[0003] Based on the above reasons, how to provide a device and method for ventricular assist system that can achieve reflux control has become a technical problem that urgently needs to be solved. Summary of the invention

[0004] The purpose of the embodiments of this specification is to address the above-mentioned problems and to provide a reflux control device for a ventricular assist system, a ventricular assist system, and a reflux control method, equipment, and readable medium.

[0005] To solve the above technical problems, the embodiments of this specification are implemented as follows:

[0006] In a first aspect, a reflux control device for a ventricular assist system is provided, comprising:

[0007] The anti-reflux speed acquisition module can obtain the target anti-reflux speed according to the current anti-reflux speed;

[0008] The speed control module can generate a speed control instruction according to the target speed and the target anti-backflow speed, and send the speed control instruction to the actuator to control the backflow degree.

[0009] Furthermore, the anti-backflow speed acquisition module can also: obtain the target anti-backflow speed according to the magnitude relationship between the current anti-backflow speed and the target speed; including:

[0010] If the current anti-backflow speed is less than or equal to the target speed, determining that the target anti-backflow speed is equal to the target speed;

[0011] If the current anti-backflow speed is greater than the target speed, a minimum value of the effective anti-backflow speed greater than the target speed is determined as the target anti-backflow speed.

[0012] Furthermore, generating a speed control instruction based on the target speed and the target anti-reflux speed includes inputting the target speed and the target anti-reflux speed into a preset speed control model to generate a speed control instruction based on the speed output by the speed control model.

[0013] Furthermore, when the target anti-backflow speed is greater than the target speed, the speed control model is determined to control the current speed to change periodically between the target speed and the target anti-backflow speed; when the target anti-backflow speed is less than or equal to the target speed, the speed is controlled to reach the target speed.

[0014] Further, when the target anti-backflow speed is greater than the target speed, determining the speed control model includes: obtaining the speed control model by segmenting the speed-time function relationship curve and setting control parameters according to the speed change trend, wherein the speed-time function is a periodic function.

[0015] Furthermore, the speed-time function relationship curve is configured as a trapezoidal wave; the trapezoidal wave is determined based on the change in slope of the current speed between the target speed and the target anti-reflux speed, including: dividing the trapezoidal wave into 4 line segments with different slopes; the control parameters of the speed control model corresponding to the line segments include the time corresponding to the change process of controlling the current speed value, and the sum of the time corresponding to the 4 line segments of the trapezoidal wave is one cardiac cycle.

[0016] Furthermore, the speed control module can also: according to the generated speed control instruction, instruct the actuator to adjust the motor current value accordingly to control the periodic change of the speed.

[0017] In the second aspect, a ventricular assist system is proposed, comprising a catheter pump and a reflux control device for the catheter pump to execute the first aspect; the catheter pump comprises a motor and an impeller; the reflux control device comprises an anti-reflux speed acquisition module and a speed control module.

[0018] In a third aspect, a reflux control method for a ventricular assist system is proposed, comprising:

[0019] Get the current anti-backflow speed;

[0020] According to the current anti-reflux speed, a target anti-reflux speed is obtained;

[0021] A speed control instruction is generated according to the target speed and the target anti-backflow speed, and the speed control instruction is sent to the actuator to control the backflow degree.

[0022] Further, the sending of the speed control instruction to the actuator includes: according to the generated speed control instruction, instructing the actuator to adjust the motor current value accordingly to control the periodic change of the speed.

[0023] In a fourth aspect, an electronic device is provided, comprising: a processor; and

[0024] A memory arranged to store computer executable instructions which, when executed, cause the processor to perform the method of the third aspect.

[0025] In a fifth aspect, a computer-readable storage medium is proposed, which stores one or more programs. When the one or more programs are executed by an electronic device including multiple application programs, the electronic device executes the method described in the third aspect.

[0026] An embodiment of the above invention has the following advantages or beneficial effects: The present invention provides a reflux control device and method and a ventricular assist system that can be used in a ventricular assist system. The scheme of the present invention can obtain a target anti-reflux speed based on the current anti-reflux speed; generate a speed control instruction based on the target speed and the target anti-reflux speed, and send the speed control instruction to the actuator to achieve the effect of controlling or reducing reflux.

[0027] The further effects of the above-mentioned non-conventional optional manner will be described below in conjunction with the specific implementation manner. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] In order to more clearly illustrate the embodiments of this specification or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments recorded in this specification. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative labor.

[0029] Figure 1 This is a schematic diagram of the architecture of the backflow control device provided in the embodiments of this specification.

[0030] Figure 2 This is a working diagram of the anti-backflow speed acquisition module in the backflow control device provided in the embodiment of this specification.

[0031] Figure 3 This is a graph showing the relationship between the motor current and time function in the reverse flow control device provided in the embodiment of this specification.

[0032] Figure 4 This is a curve diagram of the speed-time function relationship in the backflow control device provided in the embodiment of this specification.

[0033] Figure 5 This is a schematic diagram of the speed regulation device architecture provided in the embodiments of this specification.

[0034] Figure 6 This is a working diagram of the speed estimation module in the speed regulation device provided in the embodiment of this specification.

[0035] Figure 7 This is a working diagram of the speed regulation module in the speed regulation device provided in the embodiment of this specification.

[0036] Figure 8 This is one of the structural schematic diagrams of the ventricular assist system provided in the embodiments of this specification.

[0037] Fig. 9 This is the second structural schematic diagram of the ventricular assist system provided in the embodiment of this specification.

[0038] Fig.10 A schematic flow chart of the backflow control method provided in the embodiments of this specification.

[0039] Fig.11 A schematic diagram of an implementation method of anti-reflux control of a ventricular assist system provided in an embodiment of this specification.

[0040] Fig.12 A schematic diagram of the structure of an electronic device provided for one embodiment of the present specification. DETAILED DESCRIPTION

[0041] In order to enable those skilled in the art to better understand the technical solutions in this specification, the technical solutions in the embodiments of this specification will be clearly and completely described below in conjunction with the drawings in the embodiments of this specification. Obviously, the described embodiments are only part of the embodiments of this specification, not all of the embodiments. Based on the embodiments in this specification, all other embodiments obtained by ordinary technicians in this field without creative work should fall within the scope of protection of this specification.

[0042] The following is a detailed description of a reflux control scheme for a ventricular assist system involved in this specification through a specific example.

[0043] A ventricular assist system is a mechanical circulatory support device, that is, an invasive mechanical pump that pumps blood from the heart's ventricles to the rest of the body. Therefore, a ventricular assist device can be used for patients with weak heart or heart failure.

[0044] The basic principle of the ventricular assist system is to insert a catheter pump connected to an external power source between the left ventricle and the aorta, that is, at the aortic valve, when heart failure occurs. If it is right ventricular assist, it is set between the right ventricle and the pulmonary artery and at the pulmonary valve. The catheter pump has an impeller driven by a motor to rotate at high speed, pumping blood from the ventricle to the artery to supplement the part of the cardiac output that the original heart cannot provide.

[0045] In the control process based on the ventricular assist system, when the catheter pump runs at the preset speed, the arterial pressure changes periodically and the aortic valve opens and closes periodically. When the aortic valve is closed, it means that the arterial pressure is higher than the ventricular pressure. However, due to the presence of the catheter pump, the aortic valve will not close completely, resulting in a path for blood flow from the artery to the ventricle, forming aortic valve regurgitation, and aortic valve regurgitation will cause certain structural damage to the aortic valve itself.

[0046] In addition, the target speed in this specification is the speed target value of the catheter pump motor obtained based on the actual cardiac physiological state of the user of the ventricular assist system. The setting of the speed target value first hopes to obtain accurate blood pumping flow and reduce the user's adverse cardiac reactions, and can also consider avoiding or reducing the occurrence of reflux. The current anti-reflux speed is the speed value of the catheter pump motor currently set by the ventricular assist system to avoid the occurrence of reflux. The target anti-reflux speed is the speed value of the catheter pump motor that the ventricular assist system expects to set to avoid the occurrence of reflux.

[0047] Based on the above shortcomings, Figure 1 As shown, an embodiment of the present invention provides a reflux control device 100 for a ventricular assist system, including: an anti-reflux rotation speed acquisition module 110 and a rotation speed control module 120 .

[0048] In one embodiment of the present invention, the anti-reflux speed acquisition module 110 is used to obtain a target anti-reflux speed according to the current anti-reflux speed.

[0049] In one embodiment of the present invention, the anti-reflux speed acquisition module 110 is further used to obtain the target anti-reflux speed according to the magnitude relationship between the current anti-reflux speed and the target speed, such as Figure 2 As shown, including:

[0050] S211: If the current anti-backflow speed is less than or equal to the target speed, determine that the target anti-backflow speed is equal to the target speed.

[0051] S212: If the current anti-backflow speed is greater than the target speed, determine the minimum value of the effective anti-backflow speed greater than the target speed as the target anti-backflow speed.

[0052] Specifically, one of the implementation methods of obtaining the target anti-reflux speed is to obtain it based on the size relationship between the current anti-reflux speed and the target speed when the target speed is obtained. It should be noted that the target speed is a speed target value obtained based on the actual cardiac physiological state of the user of the ventricular assist system. The setting of the speed target value first hopes to obtain accurate blood pumping flow and reduce the user's adverse cardiac reactions, while considering avoiding or reducing the occurrence of reflux. Therefore, the size relationship between the target speed and the current anti-reflux speed determines how the target anti-reflux speed value is determined.

[0053] Specifically, if the current anti-backflow speed is less than or equal to the target speed, then the target speed can meet the speed requirement of the anti-backflow, that is, the target anti-backflow speed is equal to the target speed.

[0054] If the current anti-backflow speed is greater than the target speed, there are the following situations: the first situation is that the target anti-backflow speed can be accurately controlled to be equal to the current anti-backflow speed; the second situation is that the target anti-backflow speed value is not able to be controlled to the exact value of the speed, for example, there is no such gear in the speed control gear, then at this time the target anti-backflow value should be adjusted to the lowest speed gear that is greater than the target speed and can achieve anti-backflow control.

[0055] Specifically, another implementation method for obtaining the target anti-reflux speed includes directly obtaining the target anti-reflux speed based on the current anti-reflux speed. Since the current anti-reflux speed can be directly obtained, for example, directly obtained from a running ventricular assist system, then, based on the human physiological coupling system of the user of the ventricular assist system, such as the current heart rate, heart temperature, and even the pressure difference between the artery and the ventricle, etc., the target anti-reflux speed of the user of the ventricular assist system is obtained through simulation or in vitro equipment testing. The current anti-reflux speed can be obtained by a preset adjustment method to obtain the current anti-reflux speed, for example, by multiplying the current anti-reflux speed by an empirical coefficient. However, it should be understood that the implementation method for obtaining the target anti-reflux speed based on the current anti-reflux speed is not limited to the present embodiment, and any method that can obtain the target anti-reflux speed through the current anti-reflux speed is within the protection scope of the present invention.

[0056] In one embodiment of the present invention, the speed control module 120 is used to generate a speed control instruction according to the target speed and the target anti-backflow speed, and send the speed control instruction to the actuator to control the backflow degree.

[0057] In one embodiment of the present invention, the speed control instruction is generated based on the target speed and the target anti-reflux speed, including: inputting the target speed and the target anti-reflux speed into a preset speed control model, so as to generate the speed control instruction based on the speed output by the above speed control model.

[0058] In one embodiment of the present invention, when the target anti-backflow speed is greater than the target speed, the above-mentioned speed control model is determined to control the current speed to periodically change between the target speed and the target anti-backflow speed; when the target anti-backflow speed is less than or equal to the target speed, the speed is controlled to reach the target speed.

[0059] Specifically, if the target anti-backflow speed is less than or equal to the target speed, then the target speed can meet the speed requirement of the anti-backflow, that is, the generated speed control instruction is used to maintain the target speed value. If the target anti-backflow speed is greater than the target speed, the current speed is controlled by the determined speed control model to periodically change between the target speed and the target anti-backflow speed.

[0060] In one embodiment of the present invention, when the target anti-backflow speed is greater than the target speed, determining the speed control model includes: obtaining the speed time function by segmenting the speed time function relationship curve and setting control parameters according to the speed change trend, wherein the speed time function is a periodic function.

[0061] In one embodiment of the present invention, the speed control module 120 is further configured to instruct the actuator to adjust the motor current value accordingly according to the generated speed control instruction, so as to control the periodic change of the speed.

[0062] Specifically, the embodiment of the present invention is described by controlling the periodic change of the speed by controlling the motor current value. Since the larger the motor current value, the faster the speed of the catheter pump; conversely, the smaller the motor current value, the slower the speed of the catheter pump; that is, the change trend of the motor current value I is linearly positively correlated with the change trend of the catheter pump speed. Therefore, the problem of establishing a speed control model can be transformed into the problem of establishing a motor current control model.

[0063] In one embodiment of the present invention, the speed-time function relationship curve is configured as a trapezoidal wave; the trapezoidal wave is determined based on the slope change of the current speed between the target speed and the target anti-reflux speed, including: dividing the trapezoidal wave into 4 line segments with different slopes; the control parameters of the speed control model corresponding to the line segments include the time length corresponding to the change process of controlling the current speed value, and the sum of the time lengths corresponding to the 4 line segments of the trapezoidal wave is one cardiac cycle.

[0064] Specifically, based on the fact that the change trend of the motor current value I is linearly positively correlated with the change trend of the catheter pump speed N, and the problem of establishing a speed control model can be transformed into the problem of establishing a motor current control model, the motor current control model obtained in the embodiment of the present invention, that is, the motor current time function relationship curve is as follows:

[0065] I=f(A,B,C,D,N set , N nfo )

[0066] Among them, A, B, C, and D are feedback control parameters set according to the control strategy, and N nfo is the target anti-backflow speed, N set is the target speed. The control strategy is based on the actual cardiac physiological state of the ventricular assist system user, so that accurate pumping blood flow can be obtained while reducing the user's cardiac adverse reactions and avoiding or reducing the reflux phenomenon. Specifically, parameter A is Figure 3 During a cardiac cycle, the current changes from a low current value I l Rising to a high current value I h The time proportion of Figure 3 During a cardiac cycle, the current is at a high current value I h The time proportion of Figure 3 During one cardiac cycle, the current changes from a high current value I h Reduce to low current value I l The parameter D is Figure 3 During a cardiac cycle, the current is at a low current value I l The overall change cycle of the current is a cardiac cycle, which is obtained through the heart rate sensor.

[0067] For example, assuming that the overall current change cycle, i.e., one cardiac cycle, is 0.8s, the selected parameters A, B, C, and D are: 0.2, i.e., 20%, 0.35, i.e., 35%, 0.1, i.e., 10%, 0.35, i.e., 35%, i.e., the durations corresponding to parameters A, B, C, and D are 0.16s, 0.28s, 0.08s, and 0.28s, respectively. Based on the experience of anti-reflux control in catheter pumps, it is recommended that the duration corresponding to parameter A be smaller than the duration corresponding to parameter C, and the larger the duration corresponding to parameter B, the better the anti-reflux effect.

[0068] Reference Figure 3 The motor current time function relationship curve shown in FIG. 1 is based on the fact that the change trend of the motor current value I is linearly positively correlated with the change trend of the catheter pump speed N. Figure 4 The speed control model shown is the speed-time function curve. Figure 3 The high current value I in the motor current time function curve h Corresponds to Figure 4 The target anti-backflow speed N nfo , Figure 3 Medium and low current value I l Corresponds to Figure 4 The target speed N set Assuming that one cardiac cycle is 0.8s, the target anti-reflux speed N nfo The target speed N is 8000 rpm.set is 6000rpm. Therefore, it corresponds to Figure 3 When the selected parameters A, B, C and D are 0.2, 0.35, 0.1 and 0.35 respectively, Figure 4 In the test, the time for the speed to increase from 6000rpm to 8000rpm is 0.16s, and the time to maintain 8000rpm is 0.28s. The time for decreasing from 8000rpm to 6000rpm is 0.08s, and the time to maintain 6000rpm is 0.28s.

[0069] It should be noted that the configuration of the above speed-time function relationship curve as a trapezoidal wave is one implementation of the embodiment of the present invention. According to different catheter pump speed control strategies, the above speed-time function relationship curve can also be configured as different forms such as sine waves, square waves, etc., which will not be repeated here. It should be understood that any speed control strategy that can periodically control the speed between the target anti-backflow speed and the target speed and its corresponding speed-time function relationship curve are in line with the technical features of the embodiment of the present invention.

[0070] It should be noted that the above speed control model does not achieve absolute anti-reflux, but reduces reflux to a certain extent. In one embodiment, reflux may still exist during the low-speed period but not during the high-speed period; this solution achieves the function and effect of reducing reflux compared to a cardiac cycle with a full low-speed period.

[0071] In one embodiment of the present invention, the speed needs to be adjusted before the reverse flow control is implemented. Figure 5 As shown, a speed regulating device 500 for controlling the backflow of a catheter pump includes a pressure difference estimation module 510, a speed estimation module 520 and a speed regulating module 530.

[0072] In one embodiment of the present invention, the above-mentioned speed regulating device 500 is used in a ventricular assist system, and the speed regulating device directly acts on the motor of the catheter pump of the ventricular assist system to adjust the motor speed.

[0073] In one embodiment of the present invention, the pressure difference estimation module 510 is used to calculate the current anti-reflux pressure difference based on the current heart rate, heart temperature, the pressure difference between the artery and the ventricle, and the anti-reflux pressure difference estimation model.

[0074] It should be noted that the pressure difference between the artery and the ventricle is related to the specific location and method of catheter pump implantation. When the catheter pump is implanted in the aorta and left ventricle of the heart, the pressure difference between the artery and the ventricle is the pressure difference between the aorta pressure and the left ventricle pressure; when the catheter pump is implanted in the pulmonary artery and right ventricle, the pressure difference between the artery and the ventricle is the pressure difference between the pulmonary aorta pressure and the right ventricle pressure.

[0075] In one embodiment of the present invention, the ventricular assist system includes sensors, which may include heart rate sensors, temperature sensors and pressure sensors according to their functions. The current heart rate, heart temperature, arterial pressure and ventricular pressure can be obtained through the sensors, so that the pressure difference between the artery and the ventricle can be obtained through the obtained arterial pressure and ventricular pressure.

[0076] In one embodiment of the present invention, the above-mentioned pressure difference estimation module 510 also includes obtaining simulation data before calculating the current anti-reflux pressure difference; the simulation data is obtained by simulating the human body coupling system of the ventricular assist system, and the human body coupling system includes heart rate, heart temperature and pressure difference between arteries and ventricles.

[0077] In one embodiment of the present invention, obtaining simulation data of the human body coupling system includes: obtaining data of a time series and a corresponding heart rate series, a heart temperature series, and a pressure difference series between arteries and ventricles, so as to obtain simulation data of the corresponding anti-reflux pressure difference between arteries and ventricles.

[0078] In one embodiment of the present invention, in addition to the above-mentioned simulation data obtained by simulating the human coupling system of the ventricular assist system, it can also be obtained by experimental testing using in vitro tooling equipment, including setting parameters such as heart rate and temperature, and then starting the catheter pump to obtain arterial flow data, so as to test and obtain the pressure difference between the artery and the ventricle that can prevent reflux.

[0079] In one embodiment of the present invention, the anti-reflux pressure difference estimation model is obtained by training with the simulation data.

[0080] Specifically, an anti-reflux pressure difference estimation model is obtained in the experimental stage, wherein the input independent variables of the above model are the obtained heart rate, heart temperature, and the pressure difference between the artery and the ventricle when the catheter pump is not started as parameters, and the output variable is the estimated anti-reflux pressure difference critical value. In one embodiment of the present invention, the above anti-reflux pressure difference estimation model can be constructed based on a neural network model including a BP neural network model, so as to construct a nonlinear relationship between the input independent variables and the output variables.

[0081] In one embodiment of the present invention, the pressure difference estimation module 510 is also used to obtain the original pressure difference between the artery and the ventricle when the artery is in diastole. The pressure difference between the artery and the ventricle is the difference between the arterial pressure and the ventricular pressure when the catheter pump is installed in the human body and the speed of the catheter pump motor is zero.

[0082] It should be noted that the difference between arterial pressure and ventricular pressure when the catheter pump motor speed is zero is essentially the pressure difference between the artery and the ventricle; that is, the pressure difference obtained when the catheter pump speed is zero and in the diastolic period can be approximately equal to the arterial pressure.

[0083] In one embodiment of the present invention, the current heart rate, heart temperature and the pressure difference between the artery and the ventricle are input into the anti-reflux pressure difference estimation model, and the current anti-reflux pressure difference is calculated and output.

[0084] In one embodiment of the present invention, the rotation speed estimation module 520 is used to calculate the anti-reflux rotation speed according to the current estimated anti-reflux pressure difference.

[0085] In one embodiment of the present invention, the speed estimation module 520 is further configured to convert the current anti-reflux pressure difference into a corresponding anti-reflux speed according to a previously obtained catheter pump HQ curve.

[0086] Specifically, the HQ curve of the catheter pump is obtained in the scenario of in vitro testing, and is used to reflect the relationship between flow rate and pressure head, which is related to the structure, size, speed and flow rate of the catheter pump itself. Under a certain speed, the relationship between pressure head and flow rate can be obtained; under a certain flow rate, the relationship between pressure head and speed can be obtained. Therefore, in one embodiment, the corresponding anti-reflux speed value can be obtained according to the current anti-reflux pressure difference.

[0087] In one embodiment of the present invention, Figure 6 As shown, according to the catheter pump HQ curve obtained in advance, the current anti-reflux pressure difference is converted into the corresponding anti-reflux speed, including:

[0088] S611: Obtain a pressure difference sequence generated by the HQ curve at different rotation speeds.

[0089] S612: Obtain a minimum pressure difference that is greater than or equal to the current anti-backflow pressure difference from the pressure difference sequence.

[0090] S613: Determine that the rotation speed corresponding to the minimum pressure difference is the anti-backflow rotation speed.

[0091] The implementation process of step S612 to step S613 is illustrated by an example. First, the current anti-reflux pressure difference is obtained according to the above anti-reflux pressure difference estimation model, which is assumed to be 25 mmHg; then, the maximum pressure difference that can be generated by the HQ curve at different speeds is obtained, for example: when the speed is 5000 rpm, the maximum pressure difference that can be generated is 20 mmHg; when the speed is 8000 rpm, the maximum pressure difference that can be generated is 30 mmHg; then, based on the above current anti-reflux pressure difference of 25 mmHg, the corresponding speed should be between 5000 rpm and 8000 rpm. If the speed control can be accurately achieved, then according to the catheter pump HQ curve, it can be accurately converted to the speed value corresponding to the pressure difference value equal to the above current anti-reflux pressure difference of 25 mmHg. If the speed control cannot be accurately achieved, that is, the speed value can only be selected from the existing preset gears, then the lowest gear with a pressure difference value greater than or equal to the above current anti-reflux pressure difference of 25 mmHg is selected.

[0092] In one embodiment of the present invention, the speed regulating module 530 is used to generate a regulating instruction according to the current target speed and the anti-backflow speed, and send the regulating instruction to the actuator.

[0093] In one embodiment of the present invention, Figure 7 As shown, the speed adjustment module 530 generates corresponding adjustment instructions according to the magnitude relationship between the current target speed and the anti-backflow speed, including:

[0094] S711: If the current target speed is greater than or equal to the anti-backflow speed, the generated adjustment instruction includes keeping the current target speed unchanged.

[0095] S712: If the current target speed is less than the anti-backflow speed, the generated adjustment instruction includes adjusting the target speed to the anti-backflow speed, or adjusting the target speed to the lowest speed greater than the anti-backflow speed, or adjusting the target speed to periodically change between the current target speed and the anti-backflow speed.

[0096] Specifically, the target speed is a speed target value obtained based on the actual cardiac physiological state of the ventricular assist system user. The setting of the speed target value is first expected to obtain accurate blood pumping flow, reduce the user's adverse cardiac reactions, and consider avoiding or reducing the occurrence of reflux. Therefore, the size relationship between the target speed and the anti-reflux speed determines the speed adjustment instruction generated. If the current target speed itself is greater than or equal to the anti-reflux speed, then the current target speed is the optimal speed value, that is, the generated speed adjustment instruction still maintains the current target speed; if the current target speed is less than the anti-reflux speed, there are the following situations: the first situation is to directly adjust the target speed to the anti-reflux speed. The premise of this situation is that the speed value can be accurately adjusted to be equal to the anti-reflux speed; the second situation is that the anti-reflux speed is not a speed value that can be adjusted exactly, for example, there is no equal gear value in the speed adjustment gear, then the target speed value should be adjusted to the lowest speed gear greater than the anti-reflux speed value; the third situation is to comprehensively consider the cardiac physiological state of the user of the ventricular assist system, give priority to obtaining an accurate blood pumping flow and a speed that can reduce the user's adverse cardiac reactions, and on this basis, minimize the occurrence of reflux. Therefore, the speed adjustment instruction should be able to make the speed change periodically between the current anti-reflux speed and the target speed, in order to minimize the reflux phenomenon.

[0097] An embodiment of the present invention provides a ventricular assist system, such as Figure 8 As shown, it includes a catheter pump 200 and a backflow control device 100. Among them,

[0098] The catheter pump comprises a motor 210 and an impeller 220 , wherein the motor 210 drives the impeller 220 to rotate to realize the catheter pump to obtain a desired blood pumping flow rate.

[0099] The above-mentioned backflow control device 100 is used to control the backflow degree of the catheter pump, and includes an anti-backflow rotation speed acquisition module 110 and a rotation speed control module 120 .

[0100] An embodiment of the present invention provides a ventricular assist system, such as Fig. 9 As shown, a rotation speed regulating device 500 and a sensor 400 are also included.

[0101] The rotation speed regulating device 500 is used to regulate the rotation speed, and includes a pressure difference estimation module 510 , a rotation speed estimation module 520 and a rotation speed regulating module 530 .

[0102] The above-mentioned sensors 400 include, according to their functions, a heart rate sensor 410 capable of acquiring real-time heart rate, a temperature sensor 420 capable of acquiring heart temperature, and a pressure sensor 430 capable of acquiring pressure values; the above-mentioned sensors are used to respectively acquire the heart rate, heart temperature, and the pressure difference between the artery and the ventricle and send them to the pressure difference estimation module 510 of the speed regulation device 500.

[0103] refer to Fig.10 The embodiment of the present invention provides a reflux control method for a ventricular assist system, comprising:

[0104] S1001: Obtain the current anti-backflow speed.

[0105] S1002: Obtain a target anti-backflow speed according to the current anti-backflow speed.

[0106] S1003: Generate a speed control instruction according to the target speed and the target anti-backflow speed, and send the speed control instruction to the actuator to control the backflow degree.

[0107] In one embodiment of the present invention, the target anti-backflow speed is obtained based on the relationship between the current anti-backflow speed and the target speed, including: if the current anti-backflow speed is less than or equal to the target speed, determining that the above target anti-backflow speed is equal to the above target speed; and, if the current anti-backflow speed is greater than the target speed, determining that the minimum value of the effective anti-backflow speed greater than the above target speed is the above target anti-backflow speed.

[0108] In one embodiment of the present invention, a speed control instruction is generated based on a target speed and a target anti-reflux speed, including inputting the target speed and the target anti-reflux speed into a preset speed control model to generate a speed control instruction based on the speed output by the above speed control model.

[0109] In one embodiment of the present invention, when the target anti-backflow speed is greater than the target speed, the above-mentioned speed control model is determined to control the current speed to periodically change between the target speed and the target anti-backflow speed; when the target anti-backflow speed is less than or equal to the target speed, the speed is controlled to reach the target speed.

[0110] In one embodiment of the present invention, when the target anti-backflow speed is greater than the target speed, determining the speed control model includes: obtaining the speed time function by segmenting the speed time function relationship curve and setting control parameters according to the speed change trend, wherein the speed time function is a periodic function.

[0111] In one embodiment of the present invention, the above-mentioned actuator is instructed to adjust the motor current value accordingly according to the generated speed control instruction to control the periodic change of the speed.

[0112] In one embodiment of the present invention, the speed-time function relationship curve is configured as a trapezoidal wave; the trapezoidal wave is determined based on the slope change of the current speed between the target speed and the target anti-reflux speed, including: dividing the trapezoidal wave into 4 line segments with different slopes; the control parameters of the speed control model corresponding to the line segments include the time length corresponding to the change process of controlling the current speed value, and the sum of the time lengths corresponding to the 4 line segments of the trapezoidal wave is one cardiac cycle.

[0113] In one embodiment, sending the speed control instruction to the actuator includes: instructing the actuator to adjust the motor current value accordingly according to the generated speed control instruction to control the periodic change of the speed.

[0114] The present invention provides a reflux control device and method that can be used in a ventricular assist system, and a ventricular assist system. The solution of the present invention can obtain a target anti-reflux speed based on a current anti-reflux speed; generate a speed control instruction based on the target speed and the target anti-reflux speed, and send the above-mentioned speed control instruction to an actuator to achieve the effect of controlling or reducing reflux.

[0115] like Fig.11 FIG. 1 is a schematic diagram of an implementation method of anti-reflux control of a ventricular assist system according to an embodiment of the present invention. Fig.11 When the catheter pump is placed in the human body, the user's heart rate, heart temperature and arterial-ventricular pressure difference are obtained as inputs through the human body coupling system and input into the anti-reflux pressure difference estimation model to obtain the target arterial-ventricular pressure difference that can control reflux; combined with the previously obtained catheter pump HQ curve, the target arterial-ventricular pressure difference that can control reflux is converted into a target anti-reflux speed, so as to generate a corresponding speed adjustment instruction based on the target anti-reflux speed. Fig.11 One of the implementation methods of the actuator that responds to the speed adjustment instruction can include a current controller and a catheter pump, a current control model running in the current controller, and the current controller controls the catheter pump motor current to achieve the control of the motor speed; further, to achieve the target anti-backflow speed, it can be specifically implemented by adjusting the current controller control parameters, specifically including constructing a current control model, that is, a current-time relationship curve, so as to achieve the periodic control of the motor current value by comparing it with the pre-set target current value when the target anti-backflow current value is obtained; since the change trend of the motor current value is linearly positively correlated with the change trend of the motor speed value, the periodic control of the motor current value can correspond to the periodic control of the motor speed. Specifically, it can also be implemented as follows: when the catheter pump is initially running, the motor current gear can select a low current gear value, and after the anti-backflow speed estimation module outputs the target anti-backflow speed value, the corresponding gear is further adjusted to a high current gear value.

[0116] Fig.12 This is a schematic diagram of the structure of an electronic device according to an embodiment of this specification. Fig.12 At the hardware level, the electronic device includes a processor, and optionally also includes an internal bus, a network interface, and a memory. The memory may include a memory, such as a high-speed random access memory (RAM), and may also include a non-volatile memory (non-volatile memory), such as at least one disk storage. Of course, the electronic device may also include hardware required for other services.

[0117] The processor, network interface and memory can be interconnected through an internal bus, which can be an ISA (Industry Standard Architecture) bus, a PCI (Peripheral Component Interconnect) bus or an EISA (Extended Industry Standard Architecture) bus. The bus can be divided into an address bus, a data bus, a control bus, etc. For ease of representation, Fig.12 Only one bidirectional arrow is used in the diagram, but this does not mean that there is only one bus or only one type of bus.

[0118] The memory is used to store the program. Specifically, the program may include a program code, and the program code includes a computer operation instruction. The memory may include a memory and a non-volatile memory, and provides instructions and data to the processor.

[0119] The processor reads the corresponding computer program from the non-volatile memory into the memory and then runs it, forming a shared resource access control device at the logical level. The processor executes the program stored in the memory and is specifically used to perform the following operations:

[0120] Get the current anti-backflow speed;

[0121] According to the current anti-reflux speed, a target anti-reflux speed is obtained;

[0122] A speed control instruction is generated according to the target speed and the target anti-backflow speed, and the speed control instruction is sent to the actuator to control the backflow degree.

[0123] The above is as in this manual Fig.10The reflux control method for a ventricular assist system disclosed in the illustrated embodiment can be applied to a processor or implemented by a processor. The processor may be an integrated circuit chip with signal processing capabilities. In the implementation process, each step of the above method can be completed by an integrated logic circuit of hardware in the processor or instructions in the form of software. The above processor can be a general-purpose processor, including a central processing unit (CPU), a network processor (NP), etc.; it can also be a digital signal processor (DSP), an application-specific integrated circuit (ASIC), a field-programmable gate array (FPGA) or other programmable logic devices, discrete gates or transistor logic devices, discrete hardware components. The various methods, steps and logic block diagrams disclosed in the embodiments of this specification can be implemented or executed. The general-purpose processor can be a microprocessor or the processor can also be any conventional processor, etc. The steps of the method disclosed in the embodiments of this specification can be directly embodied as a hardware decoding processor for execution, or can be executed by a combination of hardware and software modules in the decoding processor. The software module can be located in a storage medium mature in the art such as a random access memory, a flash memory, a read-only memory, a programmable read-only memory, or an electrically erasable programmable memory, a register, etc. The storage medium is located in the memory, and the processor reads the information in the memory and completes the steps of the above method in combination with its hardware.

[0124] Of course, in addition to software implementation, the electronic device of the embodiments of this specification does not exclude other implementation methods, such as logic devices or a combination of software and hardware, etc., that is to say, the execution subject of the following processing flow is not limited to each logic unit, but can also be hardware or logic devices.

[0125] The embodiment of the present specification also provides a computer-readable storage medium, which stores one or more programs, wherein the one or more programs include instructions, which, when executed by a portable electronic device including a plurality of application programs, enable the portable electronic device to execute Fig.10 The reflux control method for a ventricular assist system of the illustrated embodiment is specifically used to perform the following method:

[0126] Get the current anti-backflow speed;

[0127] According to the current anti-reflux speed, a target anti-reflux speed is obtained;

[0128] A speed control instruction is generated according to the target speed and the target anti-backflow speed, and the speed control instruction is sent to the actuator to control the backflow degree.

[0129] In short, the above description is only a preferred embodiment of this specification and is not intended to limit the protection scope of this specification. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of this specification shall be included in the protection scope of this specification.

[0130] The systems, devices, modules or units described in the above embodiments may be implemented by computer chips or entities, or by products with certain functions. A typical implementation device is a computer. Specifically, the computer may be, for example, a personal computer, a laptop computer, a cellular phone, a camera phone, a smart phone, a personal digital assistant, a media player, a navigation device, an email device, a game console, a tablet computer, a wearable device, or a combination of any of these devices.

[0131] Computer readable media include permanent and non-permanent, removable and non-removable media that can be implemented by any method or technology to store information. Information can be computer readable instructions, data structures, program modules or other data. Examples of computer storage media include, but are not limited to, phase change memory (PRAM), static random access memory (SRAM), dynamic random access memory (DRAM), other types of random access memory (RAM), read-only memory (ROM), electrically erasable programmable read-only memory (EEPROM), flash memory or other memory technology, compact disk read-only memory (CD-ROM), digital versatile disk (DVD) or other optical storage, magnetic cassettes, magnetic tape magnetic disk storage or other magnetic storage devices or any other non-transmission media that can be used to store information that can be accessed by a computing device. As defined herein, computer readable media does not include temporary computer readable media (transitory media), such as modulated data signals and carrier waves.

[0132] It should also be noted that the terms "include", "comprises" or any other variations thereof are intended to cover non-exclusive inclusion, so that a process, method, commodity or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, commodity or device. In the absence of more restrictions, the elements defined by the sentence "comprises a ..." do not exclude the existence of other identical elements in the process, method, commodity or device including the elements.

[0133] Each embodiment in this specification is described in a progressive manner, and the same or similar parts between the embodiments can be referred to each other, and each embodiment focuses on the differences from other embodiments. In particular, for the system embodiment, since it is basically similar to the method embodiment, the description is relatively simple, and the relevant parts can be referred to the partial description of the method embodiment.

Claims

1. A reflux control device for a ventricular assist system, characterized in that: include: The anti-reflux speed acquisition module can obtain the target anti-reflux speed according to the current anti-reflux speed; The speed control module can generate a speed control instruction according to the target speed and the target anti-backflow speed, and send the speed control instruction to the actuator to control the backflow degree.

2. The device according to claim 1, characterized in that The anti-backflow speed acquisition module can also: obtain the target anti-backflow speed according to the magnitude relationship between the current anti-backflow speed and the target speed; including: If the current anti-backflow speed is less than or equal to the target speed, determining that the target anti-backflow speed is equal to the target speed; If the current anti-backflow speed is greater than the target speed, a minimum value of the effective anti-backflow speed greater than the target speed is determined as the target anti-backflow speed.

3. The device according to claim 1, characterized in that The generating of the speed control instruction according to the target speed and the target anti-backflow speed includes inputting the target speed and the target anti-backflow speed into a preset speed control model so as to generate the speed control instruction according to the speed output by the speed control model.

4. The device according to claim 3, characterized in that When the target anti-backflow speed is greater than the target speed, the speed control model is determined to control the current speed to change periodically between the target speed and the target anti-backflow speed; when the target anti-backflow speed is less than or equal to the target speed, the speed is controlled to reach the target speed.

5. The device according to claim 4, characterized in that When the target anti-backflow speed is greater than the target speed, determining the speed control model includes: obtaining the speed control model by segmenting the speed-time function relationship curve and setting control parameters according to the speed change trend, wherein the speed-time function is a periodic function.

6. The device according to claim 5, characterized in that The speed-time function relationship curve is configured as a trapezoidal wave; the trapezoidal wave is determined based on the slope change of the current speed between the target speed and the target anti-reflux speed, including: dividing the trapezoidal wave into 4 line segments with different slopes; the control parameters of the speed control model corresponding to the line segments include the time corresponding to the change process of controlling the current speed value, and the sum of the time corresponding to the 4 line segments of the trapezoidal wave is a cardiac cycle.

7. The device according to claim 1, characterized in that The speed control module can also: instruct the actuator to adjust the motor current value accordingly according to the generated speed control instruction, so as to control the periodic change of the speed.

8. A ventricular assist system, characterized in that: It comprises a catheter pump and a backflow control device for executing any one of claims 1 to 7 for the catheter pump; the catheter pump comprises a motor and an impeller; the backflow control device comprises an anti-backflow speed acquisition module and a speed control module.

9. A method for controlling reflux in a ventricular assist system, characterized in that: include: Get the current anti-backflow speed; According to the current anti-reflux speed, a target anti-reflux speed is obtained; A speed control instruction is generated according to the target speed and the target anti-backflow speed, and the speed control instruction is sent to the actuator to control the backflow degree.

10. The method according to claim 9, characterized in that The sending of the speed control instruction to the actuator includes: according to the generated speed control instruction, instructing the actuator to adjust the motor current value accordingly to control the periodic change of the speed.

11. An electronic device, characterized in that: include: processor; as well as A memory arranged to store computer executable instructions which, when executed, cause the processor to perform the method of claims 9 to 10.

12. A computer-readable storage medium, characterized in that: The computer-readable storage medium stores one or more programs which, when executed by an electronic device including a plurality of application programs, cause the electronic device to perform the method of claims 9 to 10.

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