Combination of antibody-drug conjugates and anti-SIRP alpha antibodies

CN119136832APending Publication Date: 2024-12-13DAIICHI SANKYO CO LTD
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Patent Information

Application Number
CN202380037780.4
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Priority Date
2022-05-10
Filing Date
2023-05-09
Publication Date
2024-12-13

AI Technical Summary

Technical Problem

Although existing antibody-drug conjugates have excellent antitumor effects when used alone, they require a method to inhibit cancer cells in a variety of ways by using in combination with another anticancer agent with different mechanisms of action. and further excellent anti-tumor effects.

Method used

Provided is a pharmaceutical composition, including a combination of an antibody-drug conjugate with an anti-SIRPα antibody, specifically a antibody such as gosatozumab, vepotentizumab and enmetrastuzumab - A combination of drug conjugates with anti-SIRPα antibodies for the treatment of various types of cancer.

Benefits of technology

Through the combination of anti-SIRPα antibodies and antibody-drug conjugates, the killing effect on cancer cells is significantly enhanced, and the anti-tumor effect and life-extended effect is achieved. It is suitable for various types of cancer treatment.

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Abstract

Provided are a pharmaceutical composition, a therapeutic method, and an anti-SIRP [alpha] antibody that are superior in terms of anti-tumor effect and safety. The pharmaceutical compositions and methods of treatment are characterized in that an anti-SIRP [alpha] antibody and at least one antibody-drug conjugate selected from the group consisting of gosatuzumab, vipostuzumab and enmetratuzumab are combined and administered. The anti-SIRP alpha antibody is characterized by being administered in combination with the antibody-drug conjugate.
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