Reagent storage device and reagent operation system

Abstract

A reagent storage device (1) and a reagent handling system, the reagent storage device comprising a reagent bin (10) comprising a bin body (11) and a bin door (12) for closing the bin body (11); the kit storage unit (20) is arranged in the bin body (11) and comprises a kit containing space (20A), and the kit containing space (20A) is configured to contain a kit (30) with a reagent storage space (30A); the puncture unit (40) comprises a sample adding needle (41) arranged in the bin body (11), the sample adding needle (41) is provided with an internal channel (41A) and a puncture end (41C), the puncture end (41C) is provided with a sample adding needle hole (41B) communicated with the internal channel (41A), and the puncture unit (40) is movably arranged relative to the kit storage unit (20) and has a first puncture working state and a second puncture working state; the puncturing unit (40) is configured in such a manner that the sample adding needle hole (41B) is communicated with the reagent storage space (30A) of the kit (30) in a first puncturing working state in a state that the kit (30) is placed in the kit accommodating space (20A), and the sample adding needle hole (41B) is disconnected from the reagent storage space (30A) of the kit (30) in a second puncturing working state in a state that the sample adding needle hole (41B) is disconnected from the reagent storage space (30A) of the kit (30).

Description

Reagent storage devices and reagent handling systems Technical Field

[0001] The present invention relates to the field of fluid manipulation technology, and in particular to a reagent storage device and a reagent operating system. Background Art

[0002] Fluid manipulation devices, such as medical testing equipment like biochemical and gene sequencers, require a series of physical and chemical reactions to test samples. These reactions require the addition of various reagents. The addition of multiple reagents during each test necessitates the design of a fluid flow path using multi-channel switching valves and multiple pipelines. Furthermore, a comprehensive sample loading mechanism is required.

[0003] As shown in FIG39 , in the related art, an external puncture and sampling mechanism 40 ′ is generally provided outside the reagent chamber 10 ′, and the external puncture and sampling mechanism 40 ′ is used to perform puncture sampling on the reagent stored in the reagent chamber 10 ′ from above.

[0004] Summary of the Invention

[0005] The invention provides a reagent storage device and a reagent operating system.

[0006] A first aspect of the present disclosure provides a reagent storage device, comprising:

[0007] A reagent chamber, comprising a chamber body and a chamber door for closing the chamber body;

[0008] a reagent box storage unit, disposed in the compartment body, comprising a reagent box accommodating space configured to accommodate a reagent box having a reagent storage space; and

[0009] The puncture unit includes a sample loading needle arranged in the warehouse body, the sample loading needle has an internal channel and a puncture end, the puncture end is provided with a sample loading needle pinhole connected to the internal channel, the puncture unit is movably arranged relative to the reagent kit storage unit and has a first puncture working state and a second puncture working state, the puncture unit is configured as follows: when the reagent kit is placed in the reagent kit accommodating space, in the first puncture working state, the sample loading needle pinhole is connected to the reagent storage space of the reagent kit, and in the second puncture working state, the sample loading needle pinhole is disconnected from the reagent storage space of the reagent kit.

[0010] In some embodiments of the reagent storage device, the reagent storage device includes two or more puncture units arranged corresponding to the same reagent cartridge accommodating space.

[0011] In some embodiments of the reagent storage device,

[0012] Among the two or more puncture units provided corresponding to the same reagent cartridge accommodating space, the puncture end of the sample addition needle of at least one puncture unit is located outside or below the bottom of the corresponding reagent cartridge accommodating space; and / or

[0013] Among the two or more puncture units arranged corresponding to the same reagent cartridge accommodating space, the puncture end of the sample addition needle of at least one puncture unit is located outside or above the top of the corresponding reagent cartridge accommodating space.

[0014] In the reagent storage device of some embodiments, the reagent kit storage unit includes a reagent kit protection portion arranged between the sample injection needle and the reagent kit accommodating space, and the reagent kit protection portion has a puncture end avoidance opening for avoiding the puncture end of the sample injection needle.

[0015] In the reagent storage device of some embodiments, at least part of the sample injection needles of the puncture unit include:

[0016] a sample injection needle tube, wherein the internal passage is located within the sample injection needle tube; and

[0017] The sampling needle tip is located at the puncture end of the sampling needle and is connected to one end of the sampling needle tube. The sampling needle tip is a cone with a cross-section gradually decreasing from the sampling needle tube to the side away from the sampling needle tube; wherein the sampling needle hole is located on the side wall of the sampling needle tube close to the sampling needle tip.

[0018] In the reagent storage device of some embodiments, the sample loading needle includes a sample loading needle tube and a sample loading needle tip located at the puncture end and connected to the sample loading needle tube, wherein:

[0019] The sample adding needle tube has at least one sample adding needle curved tube section; and / or

[0020] The sample adding needle tube has at least one flexible tube section; and / or

[0021] The sample adding needle tube has at least one telescopic tube section.

[0022] In the reagent storage device of some embodiments, the sample injection needle tube includes:

[0023] A first straight tube section of the sample loading needle extends along the wall surface of the bin body; and

[0024] The second straight tube section of the sample loading needle extends from one side of the warehouse wall surface of the warehouse body toward the reagent kit accommodating space, one end of the second straight tube section of the sample loading needle is connected to one end of the first straight tube section of the sample loading needle through the curved tube section of the sample loading needle, and the needle tip of the sample loading needle is connected to the other end of the second straight tube section of the sample loading needle.

[0025] In the reagent storage device of some embodiments, the puncture unit further includes a sample loading needle mounting portion, and the sample loading needle is fixed on the sample loading needle mounting portion.

[0026] In some embodiments of the reagent storage device, the reagent storage device further includes a puncture drive unit, including a switching portion that is drive-connected or drive-coordinated with the puncture unit, and the switching portion is configured to drive the puncture unit to switch between the first puncture working state and the second puncture working state.

[0027] In some embodiments of the reagent storage device, the reagent storage device includes two or more puncture units, and the puncture drive unit includes two or more switching parts corresponding to the puncture units, wherein at least two of the switching parts are arranged in a linked manner.

[0028] In some embodiments of the reagent storage device, the reagent storage device includes two or more puncture units arranged corresponding to the same reagent kit accommodating space, and the puncture drive unit includes two or more switching parts corresponding one to one to the two or more puncture units arranged corresponding to the same reagent kit accommodating space, and the two or more switching parts are arranged in a linkage manner so that the corresponding two or more puncture units can be synchronously switched from the first puncture working state to the second puncture working state or from the second puncture working state to the first puncture working state.

[0029] In some embodiments of the reagent storage device, the puncture unit includes a sample loading needle mounting portion and a plurality of the sample loading needles, the plurality of sample loading needles are mounted on the sample loading needle mounting portion, and the switching portion is driven connected or driven to cooperate with the sample loading needle mounting portion of the puncture unit to drive the plurality of sample loading needles to move synchronously.

[0030] In some embodiments of the reagent storage device, the switching part includes a sample loading needle driving mechanism, which is configured to apply a force to the puncture unit to switch it from the first puncture working state to the second puncture working state and / or apply a force to switch it from the second puncture working state to the first puncture working state.

[0031] In the reagent storage device of some embodiments, the sample injection needle driving mechanism includes:

[0032] a first movable portion having a first driving working position and a second driving working position;

[0033] The second movable part is driven to be connected or driven to cooperate with the first movable part and the puncture unit to transmit the action of the first movable part to the puncture unit, wherein when the first movable part is in the first driving working position, the puncture unit is in one of the first puncture working state and the second puncture working state, and when the first movable part is in the second driving working position, the puncture unit is in the other of the first puncture working state and the second puncture working state.

[0034] In the reagent storage device of some embodiments, the puncture drive unit includes a linkage portion, which is drivingly connected or drivingly coordinated with at least two of the switching portions to enable the puncture units corresponding to the at least two switching portions to move synchronously.

[0035] In the reagent storage device of some embodiments, the puncture drive unit includes:

[0036] a limiting portion, the limiting portion being configured to limit the range of motion of the first movable portion and / or the second movable portion; and / or

[0037] A guide portion is configured to guide the movement of the first movable portion and / or the second movable portion.

[0038] In some embodiments of the reagent storage device,

[0039] The limiting portion is configured to limit the range of motion of the linkage portion to limit the range of motion of the first movable portion and / or the second movable portion; and / or

[0040] The guide portion is configured to guide the movement of the linkage portion so as to guide the movement of the first movable portion and / or the second movable portion.

[0041] In some embodiments of the reagent storage device,

[0042] The limiting portion includes one or more limiting structures, at least one of the limiting structures includes a limiting groove and a limiting surface, the limiting surface is movably located in the limiting groove and is in abutment with the limiting groove, one of the limiting groove and the limiting surface is fixed relative to one of the first movable portion and the second movable portion, and the other is fixed relative to the other of the first movable portion and the second movable portion; and / or

[0043] The guide portion includes one or more guide structures, at least one guide structure includes a guide groove and a guide surface, the guide surface slides in conjunction with the guide groove, one of the guide groove and the guide surface is fixed relative to the bin body, and the other is fixed relative to the first movable portion or the second movable portion.

[0044] In some embodiments of the reagent storage device, the puncture drive unit further includes a positioning portion, which has a positioning state for maintaining the puncture unit in the first puncture working state and / or the second puncture working state and an avoidance state for preventing interference with the puncture unit switching the working position, and the positioning portion is movably arranged relative to the chamber body to switch between the avoidance state and the positioning state.

[0045] In the reagent storage device of some embodiments, the positioning portion cooperates with the reagent reagent box drive to switch between the avoidance state and the positioning state under the drive of the reagent reagent box.

[0046] In some embodiments of the reagent storage device, the positioning portion includes a slider and a slider reset mechanism. The slider is movably installed in the warehouse body relative to the warehouse body and includes a positioning surface. The slider is driven to cooperate with the reagent reagent box. In the avoidance state of the positioning portion, the slider is in an avoidance position where the positioning surface is separated from the second movable part, and the slider reset mechanism is in a force storage state. In the positioning state of the positioning portion, the slider is in a positioning position where the positioning surface is in contact with the second movable part, and the slider reset mechanism is in a force release state.

[0047] In some embodiments of the reagent storage device,

[0048] The first movable portion includes a first translation component, the first translation component is reciprocally movable relative to the bin body along a first direction, the first translation component is provided with a driving surface, and the driving surface is inclined along the first direction toward a second direction perpendicular to the first direction;

[0049] The second movable portion includes a second translation component, which is fixedly arranged relative to the sample injection needle and can be reciprocated relative to the warehouse body along the second direction. The second translation component is provided with a mating surface corresponding to the driving surface, and the mating surface is inclined along the first direction toward the second direction. By changing the position of the first translation component in the first direction, the mating position of the driving surface and the mating surface is changed to change the position of the second translation component along the second direction.

[0050] In some embodiments of the reagent storage device, the puncture drive unit includes a linkage portion, which is drivably connected to or drives and cooperates with at least two of the switching portions to enable the puncture units corresponding to the at least two switching portions to move synchronously, wherein:

[0051] The linkage portion includes a push-pull rod extending along the first direction;

[0052] The first translation component is fixed to the push-pull rod, and the driving surface is provided on a side of the push-pull rod close to the second translation component;

[0053] The second translation component includes a pressing plate, which is arranged along the second direction. The matching surface is provided at an end of the pressing plate close to the first translation component.

[0054] In some embodiments of the reagent storage device,

[0055] The puncture drive unit includes a limiting portion, which is configured to limit the movement range of the linkage portion to limit the movement range of the first movable portion, and the limiting portion includes one or more limiting structures, at least one of which includes a limiting groove and a limiting surface, and the limiting surface is movably located in the limiting groove and has an abutment state with the limiting groove, and one of the limiting groove and the limiting surface is provided on the second movable portion, and the other is provided on the push-pull rod; and / or

[0056] The puncture drive unit includes a guide portion, which is configured to guide the movement of the linkage portion to guide the movement of the first movable portion. The guide portion includes one or more guide structures, at least one guide structure includes a guide groove and a guide surface, one of the guide groove and the guide surface is fixed relative to the magazine body, and the other is arranged on the push-pull rod.

[0057] In some embodiments of the reagent storage device,

[0058] The first movable portion includes a first rotating component, and the first rotating component is rotatably arranged relative to the warehouse body;

[0059] The second movable part includes a second rotating component, which is rotatable relative to the warehouse body and is drivingly connected or drivingly matched with the first rotating component. The second rotating component drives the puncture unit to switch between the first puncture working state and the second puncture working state.

[0060] In some embodiments of the reagent storage device,

[0061] The first rotating component is a rotating shaft;

[0062] The second rotating component includes a cam arranged on the rotating shaft, and the cam is pressed and fitted with the puncture unit.

[0063] In some embodiments of the reagent storage device, the puncture drive unit further includes a movable connection portion, which is respectively connected to the cam and the puncture unit, and is configured to transmit the movement of the cam to the puncture unit so that the rotation of the cam drives the puncture unit to move.

[0064] In some embodiments of the reagent storage device, the movable connection portion includes:

[0065] a first pin, disposed on an end surface of the cam;

[0066] a second pin, arranged on the puncture unit in parallel and spaced apart from the first pin;

[0067] The movable element has an arc-shaped groove. The movable element is installed on the cam and the puncture unit through the first pin and the second pin cooperating with the arc-shaped groove. The first pin and the second pin are slidably matched with the arc-shaped groove.

[0068] In some embodiments of the reagent storage device,

[0069] The puncture drive unit includes a linkage portion, which is drivingly connected or drivingly matched with at least two of the switching portions to enable the puncture units corresponding to the at least two switching portions to move synchronously;

[0070] The linkage portion includes at least one of a belt transmission mechanism, a chain transmission mechanism, a gear transmission mechanism, a gear and rack transmission mechanism or a connecting rod mechanism connected between the first rotating components of the at least two switching portions.

[0071] In some embodiments of the reagent storage device, the puncture drive unit further includes an actuating portion, which is drivingly connected to or drivingly engaged with the first movable portion; the actuating portion includes:

[0072] a handle or a rotary handle, drivingly connected to or drivingly cooperating with the first movable part, the handle or the rotary handle being arranged on a side of the warehouse body where the warehouse door is arranged; or

[0073] An actuator is drivingly connected to or drivingly matched with the first movable part.

[0074] In some embodiments of the reagent storage device, the switching unit includes a sample injection needle reset mechanism, wherein:

[0075] One of the sample needle driving mechanism and the sample needle resetting mechanism is configured to apply a force to the puncture unit to switch the puncture unit from the first puncture working state to the second puncture working state;

[0076] The other of the sample loading needle driving mechanism and the sample loading needle resetting mechanism is configured to apply a force to the puncture unit to switch the puncture unit from the second puncture working state to the first puncture working state.

[0077] In the reagent storage device of some embodiments, the sample injection needle reset mechanism includes at least one spring; wherein,

[0078] The spring is located and / or connected between the puncture unit and the reagent kit storage unit; or

[0079] The spring is located and / or connected between the puncture unit and the cartridge body.

[0080] In some embodiments of the reagent storage device, the reagent storage device includes a plurality of the reagent kit storage units, and / or the reagent kit storage unit includes a plurality of the reagent kit accommodating spaces.

[0081] In some embodiments of the reagent storage device, the reagent storage device further includes a heat preservation unit configured to maintain the temperature of the reagent chamber.

[0082] In some embodiments of the reagent storage device, the heat preservation unit includes a refrigerant circulation system, and the refrigerant circulation system is configured to regulate the temperature inside the reagent compartment.

[0083] In some embodiments of the reagent storage device,

[0084] The reagent storage device includes a reagent kit, the reagent kit includes a reagent storage space, and the reagent kit accommodating space of the reagent storage device is used to place the reagent kit;

[0085] In the first puncture working state of the puncture unit, the sample loading needle pinhole is connected to the reagent storage space of the reagent kit placed in the reagent kit accommodating space, and in the second puncture working state of the puncture unit, the sample loading needle pinhole is disconnected from the reagent storage space of the reagent kit placed in the reagent kit accommodating space.

[0086] In the reagent storage device of some embodiments, the reagent kit has a weak portion corresponding to the puncture end of the sample loading needle. In the first puncture working state of the puncture unit, the puncture end of the sample loading needle enters the reagent storage space by piercing the weak portion to realize the connection between the sample loading needle pinhole of the sample loading needle and the reagent storage space of the reagent kit.

[0087] In some embodiments, the reagent storage device further includes a base plate, which is located in the reagent compartment and installed on the bottom wall of the compartment body, and the reagent kit storage unit and / or the puncture unit are installed on the base plate.

[0088] A second aspect of the present disclosure provides a reagent operating system, comprising the reagent storage device according to the first aspect of the present disclosure; wherein the reagent operating system further comprises:

[0089] a reagent receiving portion, which is in communication with an internal channel of the sample injection needle of at least one of the puncture units; and / or

[0090] a cleaning liquid delivery portion, which is in communication with an internal channel of the sample injection needle of at least one of the puncture units; and / or

[0091] The gas communication portion is in communication with an inner channel of the sample addition needle of at least one of the puncture units.

[0092] In the reagent operating system of some embodiments,

[0093] The reagent operating system comprises the reagent receiving portion and the cleaning liquid delivery portion, wherein the reagent receiving portion and the cleaning liquid delivery portion are respectively connected to the internal channels of the sample injection needles of different puncture units; and / or

[0094] The reagent operating system includes the cleaning liquid delivery part and the gas communication part, and the cleaning liquid delivery part and the gas communication part are in communication with the internal channel of the sample addition needle of the same puncture unit at different time periods.

[0095] In some embodiments of the reagent operating system, the reagent operating system includes the reagent receiving part and the cleaning liquid delivery part, wherein:

[0096] The puncture end of the sample addition needle of the puncture unit in communication with the reagent receiving portion is located outside or below the bottom of the corresponding reagent cartridge accommodating space;

[0097] The puncture end of the sample addition needle of the puncture unit in communication with the cleaning liquid delivery portion is located outside or above the top of the corresponding reagent cartridge accommodating space.

[0098] In the reagent operating system of some embodiments,

[0099] The reagent receiving portion is connected to the sample addition needle of at least one of the puncture units via a connecting tube having a flexible tube section or a telescopic tube section; and / or

[0100] The cleaning liquid delivery portion is connected to the sample addition needle of at least one of the puncture units via a connecting tube having a flexible tube section or a telescopic tube section; and / or

[0101] The gas communication portion is connected to the sample addition needle of at least one of the puncture units via a connecting tube having a flexible tube section or a telescopic tube section.

[0102] In the reagent operating system of some embodiments,

[0103] The reagent receiving portion is connected to the sample injection needle of at least one of the puncture units via a connecting tube that passes through the chamber body and is sealed between the chamber body; and / or

[0104] The cleaning liquid delivery portion is connected to the sample addition needle of at least one of the puncture units via a connecting tube that passes through the chamber body and is sealed between the chamber body; and / or

[0105] The gas communication portion is connected to the sample addition needle of at least one of the puncture units via a connecting tube that passes through the chamber body and is sealed with the chamber body.

[0106] The reagent storage device provided by the present disclosure is provided with a puncture unit in the reagent chamber. The sampling needle pinhole of the puncture unit can be connected or disconnected with the reagent storage space of the reagent kit, so that the puncture unit can realize the function of an external sampling mechanism. The puncture unit is coupled to the interior of the reagent chamber. Compared with the existing technology of the external sampling mechanism of the reagent chamber, there is no need to reserve multiple through holes on the reagent chamber for the sampling needle to pass through, which is conducive to isolating the internal accommodating space of the reagent chamber and the reagent kit and puncture unit therein from the air. Therefore, it is conducive to preventing a large amount of air from entering the reagent chamber to form condensed water and then carrying dust and impurities into the reagent kit to contaminate the reagents.

[0107] The reagent operating system of the present disclosure has the same advantages as the reagent storage device of the present disclosure. BRIEF DESCRIPTION OF THE DRAWINGS

[0108] The drawings described herein are used to provide a further understanding of the present invention and constitute a part of this disclosure. The exemplary embodiments of the present invention and their descriptions are used to explain the present invention and do not constitute an improper limitation of the present invention. In the drawings:

[0109] FIG1 is a schematic structural diagram of a reagent storage device according to an embodiment of the present disclosure.

[0110] FIG2 is a schematic structural diagram of the reagent storage device shown in FIG1 from another direction.

[0111] FIG3 is a schematic structural diagram of the reagent storage device shown in FIG1 , in which one reagent box is located outside the reagent box accommodating space.

[0112] FIG4 is a schematic structural diagram of the reagent storage device shown in FIG1 with the reagent compartment removed, wherein one reagent cartridge is located outside the reagent compartment.

[0113] FIG5 is a schematic structural diagram of the reagent storage device shown in FIG1 with the reagent compartment removed.

[0114] FIG6 is a schematic structural diagram of the reagent storage device shown in FIG1 from another direction with the reagent compartment removed, wherein one reagent reagent is located outside the reagent reagent accommodating space.

[0115] FIG7 is a schematic top view of the structure of the reagent storage device shown in FIG1 with the reagent compartment removed.

[0116] FIG8 is a schematic cross-sectional view of the reagent storage device shown in FIG1 with the reagent compartment removed.

[0117] FIG9 is a schematic structural diagram of the reagent storage device shown in FIG1 from another direction with the reagent compartment and the bottom plate removed, wherein one reagent reagent is located outside the reagent reagent accommodating space.

[0118] FIG10 is a schematic structural diagram of the combined structure of the reagent kit storage unit, the reagent kit, the puncture unit and the puncture drive unit of the reagent storage device shown in FIG1 , wherein the puncture unit is in the second puncture working state.

[0119] FIG11 is a schematic diagram of a partially enlarged structure of a portion of FIG10 .

[0120] FIG. 12 is a schematic structural diagram of a positioning portion of the puncture drive unit of the reagent storage device shown in FIG. 1 .

[0121] FIG13 is a schematic diagram of a partially enlarged structure of another part of FIG10.

[0122] FIG14 is a schematic structural diagram of the combined structure of the reagent kit storage unit, the reagent kit, the puncture unit, and the puncture drive unit of the reagent storage device shown in FIG1 , wherein the puncture unit is in a first puncture working state.

[0123] FIG15 is a schematic diagram of the local structure of a part of FIG14.

[0124] FIG16 is a schematic diagram of a partially enlarged structure of another part of FIG14.

[0125] FIG17 is a schematic structural diagram of the sample addition needle of the puncture unit of the reagent storage device shown in FIG1 .

[0126] FIG18 is a schematic cross-sectional view of the sample adding needle shown in FIG11 from another direction.

[0127] FIG19 is a schematic diagram of the exploded structure of the reagent kit of the reagent storage device shown in FIG1 .

[0128] FIG20 is a schematic structural diagram of a reagent storage device according to another embodiment of the present disclosure.

[0129] FIG21 is a schematic structural diagram of the reagent storage device shown in FIG20 in another direction.

[0130] FIG22 is a schematic structural diagram of the reagent storage device shown in FIG20 , in which one reagent box is located outside the reagent box accommodating space.

[0131] FIG23 is a schematic structural diagram of the reagent storage device shown in FIG20 with the reagent compartment removed.

[0132] FIG24 is a schematic structural diagram of the reagent storage device shown in FIG20 , with the reagent chamber and the heat preservation unit removed.

[0133] FIG25 is a schematic structural diagram of the reagent storage device shown in FIG20 in another direction.

[0134] FIG26 is a schematic structural diagram of the reagent storage device shown in FIG20 with the reagent compartment removed, wherein one reagent cartridge is located outside the reagent compartment.

[0135] FIG27 is a schematic structural diagram of the reagent storage device shown in FIG20 from another direction with the reagent compartment removed.

[0136] FIG28 is a schematic structural diagram of the reagent storage device shown in FIG20 from another direction with the reagent compartment removed.

[0137] FIG29 is a schematic diagram of the exploded structure of the reagent storage device shown in FIG20 , with the reagent compartment removed.

[0138] FIG30 is a schematic diagram of a partially enlarged structure of FIG29.

[0139] FIG31 is a schematic diagram of the top view of the reagent storage device shown in FIG20 .

[0140] FIG32 is a schematic diagram of the cross-sectional structure taken along the AA line of FIG31 .

[0141] FIG33 is a schematic diagram of the top view of the reagent storage device shown in FIG20 with the reagent compartment removed.

[0142] FIG34 is a schematic diagram of the three-dimensional structure viewed along line BB in FIG33 .

[0143] FIG35 is a schematic structural diagram of a portion of the reagent storage device shown in FIG20 including a puncture unit, a puncture drive unit, and a reagent kit.

[0144] FIG36 is a schematic structural diagram of a portion of the reagent storage device shown in FIG20 including a puncture unit and a puncture drive unit.

[0145] FIG37 is a schematic diagram of the exploded structure of the partial structure shown in FIG36 .

[0146] FIG38 is a schematic diagram showing the principle of a reagent operating system according to an embodiment of the present disclosure.

[0147] FIG39 is a schematic structural diagram of a reagent operating system in related art. DETAILED DESCRIPTION

[0148] The following will be combined with the accompanying drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, rather than all the embodiments. The following description of at least one exemplary embodiment is actually only illustrative and is in no way intended to limit the present invention and its application or use. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0149] Unless otherwise specifically stated, the relative arrangement of the parts and steps, the numerical expressions and the numerical values ​​set forth in these embodiments do not limit the scope of the present invention. At the same time, it should be understood that, for ease of description, the sizes of the various parts shown in the drawings are not drawn according to the actual proportional relationship. The techniques, methods and equipment known to those of ordinary skill in the relevant art may not be discussed in detail, but where appropriate, the techniques, methods and equipment should be considered as part of the authorization specification. In all examples shown and discussed here, any specific values ​​should be interpreted as being merely exemplary and not as limiting. Therefore, other examples of the exemplary embodiments may have different values. It should be noted that similar numbers and letters represent similar items in the following figures, and therefore, once an item is defined in one figure, it does not need to be further discussed in subsequent figures.

[0150] In the process of realizing the present disclosure, the inventors discovered the following phenomena in the related art:

[0151] The external loading mechanism 40', located outside the reagent chamber 10', is not well isolated from the air, resulting in a high level of condensation. Specifically, the reagent chamber 10' has a refrigeration function and has multiple through-holes on its top for the loading needles 41' to pass through. This allows ambient air to easily enter the chamber 10' through these holes, forming condensation, which then carries dust and impurities into the reagent kit, contaminating the reagents.

[0152] When the sample loading mechanism 40 ′ is externally installed, the total volume of the sample loading mechanism 40 ′ and the reagent chamber 10 ′ is too large.

[0153] It is difficult to achieve automatic cleaning of the sample adding needle 41 ' of the sample adding mechanism 40 ' or it is difficult to clean the sample adding needle 41 ' automatically.

[0154] In order to solve the aforementioned problems, the embodiments of the present disclosure provide a reagent storage device 1 and a reagent operating system.

[0155] As shown in Figures 1 to 37, the reagent storage device 1 of the embodiment of the present disclosure includes a reagent tank 10, a reagent kit storage unit 20 and a puncture unit 40. The reagent tank 10 includes a tank body 11 and a tank door 12 for closing the tank body 11. The reagent kit storage unit 20 is arranged in the tank body 11, including a reagent kit accommodating space 20A, and the reagent kit accommodating space 20A is configured to place a reagent kit 30 having a reagent storage space 30A. The puncture unit 40 includes a sample loading needle 41 arranged in the tank body 11. The sample loading needle 41 has an internal channel 41A and a puncture end 41C, and the puncture end 41C is provided with a sample loading needle hole 41B connected to the internal channel 41A. The puncture unit 40 is movably arranged relative to the reagent kit storage unit 20 and has a first puncture working state and a second puncture working state. The puncture unit 40 is configured as follows: when the reagent kit 30 is placed in the reagent kit accommodating space 20A, in a first puncture working state, the sample needle hole 41B is connected to the reagent storage space 30A of the reagent kit 30; in a second puncture working state, the sample needle hole 41B is disconnected from the reagent storage space 30A of the reagent kit 30.

[0156] The reagent storage device 1 of the embodiment of the present disclosure is provided with a puncture unit 40 in the reagent chamber 10. The sample loading needle hole 41B of the sample loading needle 41 of the puncture unit 40 can be connected to or disconnected with the reagent storage space 30A of the reagent reagent box 30, so that the puncture unit 40 can realize the function of an external sample loading mechanism. The puncture unit 40 is coupled to the interior of the reagent chamber 10. Compared with the existing technology in which the sample loading mechanism is external to the reagent chamber 10, there is no need to reserve multiple through holes on the reagent chamber 10 for the sample loading needle to pass through, which is conducive to isolating the internal accommodating space of the reagent chamber 10 and the reagent reagent box 30 and the puncture unit 40 therein from the air. Therefore, it is conducive to preventing a large amount of air from entering the reagent chamber to form condensed water and then carrying dust and impurities into the reagent reagent box to contaminate the reagent.

[0157] In the embodiment shown in Figures 1 to 37, the reagent chamber 10 includes a chamber body 11 and a chamber door 12 for closing the chamber body 11. The chamber body 11 and the chamber door 12 together form an internal storage space of the reagent chamber 10. The chamber body 11 is, for example, a cube with an opening toward one side of the chamber body 11. In embodiments not shown, the chamber body 11 can be configured in other shapes, such as a cylindrical shape.

[0158] In the embodiments shown in Figures 1 to 37, in some embodiments of the reagent storage device 1, the door 12 is hingedly connected to the chamber body 11. The opening of the chamber body 11 faces the side of the chamber body 11, and the door 12 is hingedly connected to one side of the chamber body 11. In embodiments not shown, the chamber body 11 and the door 12 can be hingedly connected to the top surface of the chamber body 11, or the chamber body 11 and the door 12 can be detachably connected by a buckle or other means to achieve opening and closing of the chamber body 11.

[0159] The reagent kit 30 may include only one reagent storage space 30A or multiple reagent storage spaces 30A. For example, in the embodiments shown in Figures 1 to 37, the number of reagent storage spaces 30A is multiple. When the reagent kit 30 has multiple reagent storage spaces 30A, the reagent kit 30 may have only a single reagent kit body 31, and the multiple reagent storage spaces are separated into multiple reagent storage spaces by a partition wall within the single reagent kit body 31. When the reagent kit 30 has multiple reagent storage spaces 30A, the reagent kit 30 may also include multiple reagent kit bodies 31. Among the multiple reagent kit bodies 31, each reagent kit body 31 may include only a single reagent storage space, or some of the reagent kit bodies 31 may include a single reagent storage space, while another part of the reagent kit bodies 31 may include multiple reagent storage spaces, or all of the reagent kit bodies 31 may include multiple reagent storage spaces.

[0160] In the embodiments shown in Figures 1 to 37, in the reagent storage device 1 of some embodiments, the reagent kit 30 included in the reagent storage device 1 or used in conjunction with the reagent storage device 1 includes a plurality of reagent kit boxes 31, and each reagent kit box 31 has a single reagent storage space 30A.

[0161] In each embodiment of the present disclosure, "plurality" refers to more than two, for example, two, three, five, eight, thirteen, etc.

[0162] In some embodiments of the reagent storage device 1, the reagent storage device 1 includes two or more puncture units 40 corresponding to the same reagent cartridge accommodating space 20A. For example, in the embodiments shown in Figures 1 to 37, two puncture units 40 are provided corresponding to the same reagent cartridge accommodating space 20A.

[0163] The reagent storage device 1 includes two or more puncture units 40 corresponding to the same reagent kit accommodating space 20A. The sampling needles 41 of different puncture units 40 can be connected to the required functional modules, such as a reagent receiving part, a cleaning liquid delivery part or a gas connecting part, according to different needs, to achieve different functions such as sampling, improving the working efficiency of the sampling needle 41 or cleaning the sampling needle 41.

[0164] In the reagent storage device 1 of some embodiments, among the two or more puncture units 40 corresponding to the same reagent reagent accommodating space 20A, the puncture end 41C of the sample loading needle 41 of at least one puncture unit 40 is located outside or below the bottom of the corresponding reagent reagent accommodating space 20A; and / or among the two or more puncture units 40 corresponding to the same reagent reagent accommodating space 20A, the puncture end 41C of the sample loading needle 41 of at least one puncture unit 40 is located outside or above the top of the corresponding reagent reagent accommodating space 20A.

[0165] This arrangement facilitates the configuration of two or more puncture units 40 corresponding to the same reagent cartridge storage space 20A, each puncture unit 40 fulfilling different functions. When the puncture end 41C of the sample needle 41 of the puncture unit 40 is located outside or below the bottom of the corresponding reagent cartridge storage space 20A, a small movement of the puncture unit 40 can connect and disconnect the sample needle hole 41B of the puncture end 41C with the reagent storage space 30A of the reagent cartridge 30, thereby evacuating the reagent from the reagent storage space 30A. When the puncture end 41C of the sample needle 41 of the puncture unit 40 is located outside or above the top of the corresponding reagent cartridge storage space 20A, a small movement of the puncture unit 40 can connect and disconnect the sample needle hole 41B of the puncture end 41C with the reagent storage space 30A of the reagent cartridge 30, thereby injecting reagent, cleaning fluid, or gas into the reagent storage space 30A. Since the corresponding puncture unit 40 only needs to move slightly, there is no need to reserve a large space for the puncture unit, thereby facilitating the miniaturization of the reagent storage device.

[0166] In the embodiments shown in Figures 1 to 37, two upper and lower puncture units 40 are provided corresponding to each reagent cartridge storage space 20A. The puncture end 41C of the sample loading needle 41 of the lower puncture unit 40 is located below the corresponding reagent cartridge storage space 20A. The lower puncture unit 40 is used to extract the reagent from the reagent cartridge 30. The puncture end 41C of the sample loading needle 41 of the upper puncture unit 40 is located above the corresponding reagent cartridge storage space 20A. The upper puncture unit 40 can be used to connect to the gas when the lower puncture unit 40 extracts the reagent from the reagent cartridge 30 to facilitate extraction of the reagent. It can also be used to introduce a cleaning solution into the reagent storage space 30A to clean the sample loading needle 41 of the lower puncture unit 40 after the lower puncture unit 40 extracts the reagent from the reagent cartridge 30.

[0167] In the reagent storage device 1 of some embodiments, the reagent kit storage unit 20 includes a reagent kit protection portion 21 arranged between the sample injection needle 41 and the reagent kit accommodating space 20A, and the reagent kit protection portion 21 has a puncture end avoidance port 21A for avoiding the puncture end 41C of the sample injection needle 41.

[0168] The reagent kit protection portion 21 is provided to easily protect the reagent kit 30, preventing the reagent kit 30 from touching the sample injection needle 41 during the process of entering the reagent kit accommodating space 20A, and to facilitate accurate positioning of the reagent kit 30 inside the reagent kit storage unit 20, so that when the puncture unit 40 switches its working position, the sample injection needle hole 41B of the sample injection needle 41 can be accurately connected to or disconnected from the corresponding reagent storage space 30A according to the working position of the puncture unit 40.

[0169] The reagent kit guard portion 21 is, for example, a reagent kit guard plate. In the embodiments shown in Figures 1 to 37, each reagent kit storage unit 20 includes two parallel, spaced-apart square reagent kit guard plates, one above the other. A connecting rod 22 is provided at each corner of the upper and lower reagent kit guard plates, and each connecting rod 22 is fixedly connected to the upper and lower reagent kit guard plates. Each connecting rod 22 passes through the upper and lower reagent kit guard plates. The upper and lower ends of the connecting rod 22 are located above and below the upper and lower reagent kit guard plates, respectively. In embodiments not shown, the reagent kit guard portion 21 can also be in other forms, such as a mesh plate, a frame, or a track.

[0170] In some embodiments of the reagent storage device 1, as shown in Figures 17 and 18, at least part of the sample loading needle 41 of the puncture unit 40 includes a sample loading needle tube 411 and a sample loading needle tip 412. An internal channel 41A is located within the sample loading needle tube 411. The sample loading needle tip 412 is located at the puncture end 41C of the sample loading needle 41 and is connected to one end of the sample loading needle tube 411. The sample loading needle tip 412 is a cone with a cross-section that gradually decreases from the sample loading needle tube 411 toward the side away from the sample loading needle tube 411. The sample loading needle hole 41B is located on the side wall of the sample loading needle tube 411 near the sample loading needle tip 412.

[0171] The structure of the sample loading needle 41 is conducive to designing the sample loading needle hole 41B of the sample loading needle 41 to be closer to the wall of the reagent storage space 30A or the adjacent wall penetrated by the sample loading needle 41. Therefore, when the sample loading needle 41 is located outside or below the bottom of the reagent storage space 30A, it is conducive to the complete outflow of the reagent in the reagent storage space 30A. When the sample loading needle 41 is located outside or above the top of the reagent storage space 30A, it is conducive to the entry of gas or cleaning agent into the reagent storage space 30A.

[0172] In the reagent storage device 1 of some embodiments, as shown in Figures 4-10, 14, 17-18, 23-24, 26-29, and 32-37, the sample loading needle 41 includes a sample loading needle tube 411 and a sample loading needle tip 412 connected to the sample loading needle tube 411 at the puncture end 41C; wherein, the sample loading needle tube 411 has at least one sample loading needle bent tube segment 4112; and / or the sample loading needle tube 411 has at least one flexible tube segment; and / or the sample loading needle tube 411 has at least one telescopic tube segment.

[0173] The sample needle tube 411 is provided with at least one sample needle bent tube section 4112, which is conducive to reasonably setting the shape of the sample needle 41 according to the surrounding environment of the sample needle 41, saving the space occupied by the sample needle 41 and the required active space, and helping to reduce the volume and cost of the reagent storage device 1.

[0174] The sample needle tube 411 has at least one flexible tube section and / or the sample needle tube 411 has at least one telescopic tube section, which helps prevent the structure of the sample needle 41 from being damaged or the part connected to the sample needle from being affected when the puncture unit 40 switches the working state.

[0175] In the reagent storage device 1 of some embodiments, as shown in Figures 17-18, the sample injection needle tube 411 includes a first sample injection needle straight tube section 4111, a sample injection needle curved tube section 4112, and a second sample injection needle straight tube section 4113. The first sample injection needle straight tube section 4111 extends along the wall surface of the storage body 11. The second sample injection needle straight tube section 4113 extends from one side of the wall surface of the storage body 11 toward the reagent reagent storage space 20A. One end of the second sample injection needle straight tube section 4113 is connected to one end of the first sample injection needle straight tube section 4111 via a sample injection needle curved tube section 4112, and the sample injection needle tip 412 is connected to the other end of the second sample injection needle straight tube section 4113.

[0176] The above arrangement is beneficial for reasonably saving the space occupied by the sample addition needle 41 and its movable space with the least number of curved pipe sections.

[0177] In the reagent storage device 1 of some embodiments, as shown in Figures 4-10, 14, 17-18, 23-24, 26-29, and 32-37, the puncture unit 40 also includes a sample needle mounting portion 42, and the sample needle 41 is fixed on the sample needle mounting portion 42.

[0178] The sample needle mounting portion 42 can be, for example, a mounting plate, a mesh plate, a mounting frame, a mounting rod, etc. In the embodiments shown in Figures 1 to 37, the sample needle mounting portion 42 is a mounting plate. The sample needle 41 is mounted on the sample needle mounting portion 42 via its fixed connection portion 413.

[0179] The provision of the sample needle mounting portion 42 facilitates accurate positioning of the sample needle 41 and enables the puncture unit 40 to switch between the first puncture working state and the second puncture working state by driving the sample needle mounting portion 42, thereby also facilitating accurate control of the working position of the sample needle 41 and reducing damage to the sample needle 41.

[0180] In some embodiments of the reagent storage device 1, as shown in Figures 1, 3-16, 20, 22-30, and 32-37, the reagent storage device 1 further includes a puncture drive unit 50. The puncture drive unit 50 includes a switching portion 51, which is drivingly connected to or drivingly engaged with the puncture unit 40 and is configured to drive the puncture unit 40 to switch between a first puncture operating state and a second puncture operating state.

[0181] The switching portion 51 is provided to facilitate driving the puncture unit 40 to switch between the first puncture working state and the second puncture working state.

[0182] In some embodiments of the reagent storage device 1, as shown in Figures 1, 3-16, 20, 22-30, and 32-37, the reagent storage device 1 includes two or more puncture units 40. When the reagent storage device 1 includes two or more puncture units 40, the reagent storage device 1 includes two or more switching parts 51, and the two or more switching parts 51 are driven to connect or drive to cooperate with the two or more puncture units 40 in a one-to-one correspondence.

[0183] This arrangement facilitates controlling the actions of each puncture unit 40 through the switching portion 51 , so as to accurately and / or quickly implement the actions required to be performed by each puncture unit 40 .

[0184] In the reagent storage device 1 of some embodiments, as shown in Figures 1, 3-16, 20, 22-30, and 32-37, the reagent storage device 1 includes more than two puncture units 40, and the puncture drive unit 50 includes more than two switching parts 51 corresponding to the puncture units 40, wherein at least two switching parts 51 are arranged in a linkage manner.

[0185] At least two switching parts 51 are arranged in a linked manner, which is conducive to achieving the required action switching of the required puncture unit 40 with fewer operating steps.

[0186] In the embodiment shown in Figures 1 to 37, the reagent storage device 1 includes four puncture units 40. The reagent storage device 1 has two reagent reagent storage spaces 20A, with a puncture unit 40 disposed on the upper and lower sides of each reagent reagent storage space 20A. The reagent storage device 1 includes four switching portions 51. Each reagent reagent storage space 20A is provided with two puncture units 40 and two switching portions 51. The two switching portions 51 corresponding to the same reagent reagent storage space 20A are configured in a coordinated manner to simultaneously actuate the two puncture units 40 corresponding to the same reagent reagent storage space 20A.

[0187] In some embodiments of the reagent storage device 1, the reagent storage device 1 includes two or more puncture units 40 corresponding to the same reagent kit accommodating space 20A, and the puncture drive unit 50 includes two or more switching parts 51 corresponding one to one to the two or more puncture units 40 corresponding to the same reagent kit accommodating space 20A, and the two or more switching parts 51 are arranged in a linkage manner so that the corresponding two or more puncture units 40 can be synchronously switched from the first puncture working state to the second puncture working state or from the second puncture working state to the first puncture working state.

[0188] The two or more switching parts 51 corresponding to the two or more puncture units 40 corresponding to the same reagent box accommodating space 20A are arranged in a linkage manner, so that the corresponding two or more puncture units 40 are synchronously switched from the first puncture working state to the second puncture working state or from the second puncture working state to the first puncture working state, which is beneficial for the puncture units 40 corresponding to the same reagent box accommodating space 20A to synchronously switch the working positions, thereby simplifying the operation steps and accurately corresponding to the working positions of different puncture units 40, which is beneficial to reducing operational errors.

[0189] In the embodiments shown in Figures 1 to 37, the two puncture units 40 corresponding to the same reagent kit accommodating space 20A are synchronously switched from the first puncture working state to the second puncture working state, and synchronously switched from the second puncture working state to the first puncture working state under the linkage action of the corresponding two switching parts 51.

[0190] In the reagent storage device 1 of some embodiments, as shown in Figures 1, 3-16, 20, 22-30, and 32-37, the puncture unit 40 includes a sample loading needle mounting portion 42 and multiple sample loading needles 41, and the multiple sample loading needles 41 are mounted on the sample loading needle mounting portion 42. The switching portion 51 is driven to be connected or driven to cooperate with the sample loading needle mounting portion 42 of the puncture unit 40 to drive the multiple sample loading needles 41 to move synchronously.

[0191] This arrangement facilitates the switching portion 51 to drive the multiple sample adding needles 41 to move synchronously, thereby improving the switching efficiency of the working position of the puncture unit 40 and enabling each sample adding needle 41 to be synchronously connected to or disconnected from the corresponding reagent storage space 30A.

[0192] In the reagent storage device 1 of some embodiments, as shown in Figures 4-6, 8-10, 14, 23-24, 26-29, 32, and 34-37, the switching unit 51 includes a sample needle driving mechanism 511. The sample needle driving mechanism 511 is configured to apply a force to the puncture unit 40 to switch it from the first puncture operating state to the second puncture operating state and / or to apply a force to switch it from the second puncture operating state to the first puncture operating state.

[0193] In the embodiment shown in FIG. 1 to FIG. 37 , the sample injection needle driving mechanism 511 is configured to apply a force to the puncture unit 40 to switch the puncture unit 40 from the first puncture working state to the second puncture working state.

[0194] In the reagent storage device 1 of some embodiments, as shown in Figures 4-6, 8-11, 13-16, 23-24, 26-30, and 32-37, the sample needle drive mechanism 511 includes a first movable portion 5111 and a second movable portion 5112. The first movable portion 5111 has a first drive working position and a second drive working position. The second movable portion 5112 is drivingly connected or drivingly engaged with the first movable portion 5111 and the puncture unit 40. When the first movable portion 5111 is in its first drive working position, the puncture unit 40 is in one of its first puncture working state and its second puncture working state. When the first movable portion 5111 is in its second drive working position, the puncture unit 40 is in the other of its first puncture working state and its second puncture working state.

[0195] The sample needle driving mechanism 511 includes a first movable part 5111 and a second movable part 5112, which is conducive to the flexible setting of the sample needle driving mechanism 511. For example, the direction and magnitude of the force at the input end and the output end of the switching part 51 can be changed by setting the first movable part 5111 and the second movable part 5112, which is conducive to realizing the linkage between the switching parts 51 and the limiting, guiding, positioning and other functions of the switching part 51.

[0196] In the embodiment shown in Figures 1 to 37, the sample needle drive mechanism 511 includes a first movable portion 5111 and a second movable portion 5112. The first movable portion 5111 has a first drive operating position and a second drive operating position. The second movable portion 5112 is drivingly connected or drivingly engaged with the first movable portion 5111 and the puncture unit 40. When the first movable portion 5111 is in its first drive operating position, the puncture unit 40 is in its first puncture operating state. When the first movable portion 5111 is in its second drive operating position, the puncture unit 40 is in its second puncture operating state.

[0197] In the reagent storage device 1 of some embodiments, as shown in Figures 4-6, 9-10, 13-16, 23-24, 26-30, and 32-37, the puncture drive unit 50 includes a linkage part 52, which is driven to be connected or driven to cooperate with at least two switching parts 51 so that the puncture units 40 corresponding to the at least two switching parts 51 move synchronously.

[0198] Providing a linkage portion 52 connecting at least two switching portions 51 is beneficial for achieving synchronous control of different puncture units 40 .

[0199] In some embodiments of the reagent storage device 1, as shown in Figures 4-6, 8-11, and 13-16, the puncture drive unit 50 includes a limiter 53 and / or a guide 54. The limiter 53 is configured to limit the range of motion of the first movable portion 5111 and / or the second movable portion 5112. The guide 54 is configured to guide the movement of the first movable portion 5111 and / or the second movable portion 5112.

[0200] The puncture drive unit 50 includes a limiting portion 53 and / or a guide portion 54, which is beneficial for preventing the puncture unit 40 from excessive movement by limiting the movement range of the first movable portion 5111 and / or the second movable portion 5112, so that the puncture unit 40 can switch between the first puncture working state and the second puncture working state more accurately and quickly.

[0201] In the reagent storage device 1 of some embodiments, as shown in Figures 4-6, 8-11, and 13-16, the limiting portion 53 is configured to limit the movement range of the linkage portion 52 to limit the movement range of the first movable portion 5111 and / or the second movable portion 5112; and / or the guide portion 54 is configured to guide the movement of the linkage portion 52 to guide the movement of the first movable portion 5111 and / or the second movable portion 5112.

[0202] The limiting portion 53 limits the movement range of the first movable portion 5111 and / or the second movable portion 5112 by limiting the movement range of the linkage portion 52, which is beneficial for achieving synchronous limiting of the puncture unit 40 linked by the linkage portion 52 and can reduce the components or structures used for limiting.

[0203] The guide portion 54 is configured to guide the movement of the linkage portion 52 to guide the movement of the first movable portion 5111 and / or the second movable portion 5112, which is beneficial for synchronously guiding the puncture unit 40 linked by the linkage portion 52 and can reduce the components or structures used for guidance.

[0204] In the reagent storage device 1 of some embodiments, as shown in Figures 4-6, 9-11, and 13-16, the limiting portion 53 includes one or more limiting structures, at least one of which includes a limiting groove 53A and a limiting surface 53B. The limiting surface 53B is movably located within the limiting groove 53A and is in abutment with the limiting groove 53A. One of the limiting groove 53A and the limiting surface 53B is fixed relative to one of the first movable portion 5111 and the second movable portion 5112, and the other is fixed relative to the other of the first movable portion 5111 and the second movable portion 5112.

[0205] In the reagent storage device 1 of some embodiments, as shown in Figures 4-6, 9-11, and 13-16, the guide portion 54 includes one or more guide structures, at least one guide structure includes a guide groove 54A and a guide surface 54B, the guide surface 54B slides with the guide groove 54A, one of the guide groove 54A and the guide surface 54B is fixed relative to the chamber body 11, and the other is fixed relative to the first movable portion 5111 or the second movable portion 5112.

[0206] At least one limiting structure of the limiting portion 53 is configured to include a limiting groove 53A and a limiting surface 53B. The structure is simple and the movable range of the movable component to be controlled by the limiting portion 53 is accurately defined.

[0207] At least one guiding structure of the guiding portion 54 is configured to include a guiding groove 54A and a guiding surface 54B, which has a simple structure and is conducive to accurately guiding the movement direction of the movable component to be guided by the guiding portion 54.

[0208] As shown in FIG. 13 and FIG. 16 , the limiting surface 53B is provided on the limiting protrusion 531 .

[0209] As shown in Figures 4-6, 9-11, and 13-16, the puncture drive unit 50 includes multiple guide structures, each of which includes a guide groove 54A and a corresponding guide surface 54B. The guide groove 54A is provided on the push-pull rod 521, and the guide surface 54B is a portion of the surface of the support column 22 or is provided on a guide pin 541 on the support column 22.

[0210] In some embodiments of the reagent storage device 1, as shown in Figures 4-6, 9-12, and 14-15, the puncture drive unit 50 further includes a positioning portion 55. The positioning portion 55 has a positioning state for maintaining the puncture unit 40 in the first puncture operating state and / or the second puncture operating state, and a retracting state for preventing interference with the puncture unit 40 from switching its operating position. The positioning portion 55 is movably disposed relative to the storage body 11 to switch between the retracting state and the positioning state.

[0211] The positioning portion 55 can be switched between its positioned state and its avoidance state by, for example, locking or unlocking the position of at least one of the first movable portion 5111, the second movable portion 5112, the linkage portion 52, and the sample needle mounting portion 42 of the puncture unit 40. For example, in the embodiment shown in Figures 1 to 19, the positioning portion 55 is switched between its positioned state and its avoidance state by locking and unlocking the position of the second movable portion 5112.

[0212] The positioning portion 55 is provided, and the second movable portion 5112 can be stably maintained in the desired position without the switching portion 51 continuously applying a driving force to the second movable portion 5112, thereby making the puncture device 40 stably in the second puncture working state, which helps to prevent interference between the reagent kit 30 and the puncture needle 41 of the puncture device 40 when the reagent kit 30 is replaced.

[0213] In the reagent storage device 1 of some embodiments, as shown in FIG. 4-6 , FIG. 9 - 12 , and FIG. 14 - 15 , the positioning portion 55 is driven to cooperate with the reagent reagent 30 to switch between the avoidance state and the positioning state driven by the reagent reagent 30 .

[0214] For example, when the reagent cassette 30 is placed in the reagent cassette accommodating space 20A, the positioning portion 55 is in the retracted state. When the reagent cassette 30 is taken out of the reagent cassette accommodating space 20A, the positioning portion 55 is in the positioned state.

[0215] The positioning portion 55 is driven by the reagent box 30 to switch between the avoidance state and the positioning state. There is no need to perform special operations on the positioning portion 55, which simplifies the operating steps and allows the positioning portion 55 to be accurately in its required working state as the reagent box 30 enters and exits the reagent box accommodating space 20A.

[0216] In the reagent storage device 1 of some embodiments, as shown in Figure 12, the positioning portion 55 includes a slider 551 and a slider reset mechanism 552. The slider 551 is movably installed in the warehouse body 11 relative to the warehouse body 11 and includes a positioning surface 5511D. The slider 551 is driven to cooperate with the reagent reagent 30. In the avoidance state of the positioning portion 55, the slider 551 is in an avoidance position in which the positioning surface 5511D is separated from the second movable portion 5112, and the slider reset mechanism 552 is in a force storage state. In the positioning state of the positioning portion 55, the slider 551 is in a positioning position in which the positioning surface 5511D is in contact with the second movable portion 5112, and the slider reset mechanism 552 is in a force release state.

[0217] In the embodiment shown in FIG. 1 to FIG. 19 , the slider reset mechanism 552 includes a spring located inside the slider 551 and having two ends pressing against the slider 511 and the support column 22 , respectively.

[0218] In the reagent storage device 1 of some embodiments, as shown in Figures 4-6, 9-11, and 13-16, the first movable portion 5111 includes a first translation component 51111, which is reciprocally movable relative to the chamber body 11 along the first direction X, and the first translation component 51111 is provided with a driving surface 51111A, which is inclined along the first direction X toward a second direction Z perpendicular to the first direction X; the second movable portion 5112 includes a second translation component 51111. The second translation component 51121 is fixedly arranged relative to the sample injection needle 41 and is reciprocably arranged relative to the chamber body 11 along the second direction Z. The second translation component 51121 is provided with a mating surface 51121A corresponding to the driving surface 51111A. The mating surface 51121A is inclined along the first direction X toward the second direction Z. By changing the position of the first translation component 51111 in the first direction X, the mating position of the driving surface 51111A and the mating surface 51121A is changed to change the position of the second translation component 51121 along the second direction Z.

[0219] In some embodiments of the reagent storage device 1, as shown in Figures 4-6, 9-11, and 13-16, the puncture drive unit 50 includes a linkage portion 52, which is drivingly connected to or drivingly engaged with at least two switching portions 51 to synchronize the movement of the puncture units 40 corresponding to the at least two switching portions 51. The linkage portion 52 includes a push-pull rod 521 extending along a first direction X; a first translation member 51111 is fixed to the push-pull rod 521, with a driving surface 51111A disposed on a side of the push-pull rod 521 proximate to a second translation member 51121; and the second translation member 51121 includes a pressure plate arranged along a second direction Z, with a mating surface 51121A disposed at an end of the pressure plate proximate to the first translation member 51111.

[0220] The driving surface 51111A may include a curved surface and / or a flat surface, and the mating surface 51121A may include a curved surface and / or a flat surface. The driving surface 51111A and the mating surface 51121A may be, for example, a flat surface, a curved surface, a combination of a flat surface and a flat surface, or a combination of a flat surface and a curved surface. Preferably, the driving surface 51111A and the mating surface 51121A are both mutually cooperating curved surfaces or both mutually cooperating flat surfaces. The number of the driving surfaces 51111A and the mating surfaces 51121A may be set according to the driving requirements.

[0221] For example, as shown in Figures 4-6, 9-11, and 13-16, the first translation component 51111 includes a protrusion provided on the linkage part 52 (such as the push-pull rod 521), and the driving surface 51111A includes a curved surface of the protrusion protruding from the linkage part 52 (such as the push-pull rod 521) toward the side of the second translation component 51121 (such as the pressure plate), such as an arcuate surface. Correspondingly, the mating surface 51121A includes an end portion of the second translation component 51121 (such as the pressure plate) facing the linkage part 52 (such as the push-pull rod 521) and a curved surface protruding toward the side away from the linkage part 52 (such as the push-pull rod 521), such as an arcuate surface.

[0222] As the linkage part 52 (such as the push-pull rod 521) translates along the first direction X, when the curved surface on the linkage part 52 (such as the push-pull rod 521) is located within the curved surface provided on the translation component (such as the pressure plate), that is, when the two curved surfaces are convex and concave, the first translation component 51111 is in its first driving working position. At this time, the puncture end 41C of the sample loading needle 41 of the puncture unit 40 enters the reagent storage space 30A. If the reagent reagent 30 is installed in the reagent reagent storage space 20A, the sample loading needle pinhole 41B is connected to the reagent storage space 30A of the reagent reagent 30, and the required substance can be introduced into the reagent storage space 30A through the sample loading needle 41, or the substance can be drawn out from the reagent storage space to the end of the sample loading needle 41 away from the puncture end 41C.

[0223] As the linkage part 52 (such as the push-pull rod 521) translates along the first direction X, when the curved surface on the linkage part 52 (such as the push-pull rod 521) leaves the curved surface of the translation part (such as the pressure plate), that is, when the two curved surfaces release the convex and concave fit, the first translation part 51111 is in its second driving working position. At this time, the puncture end 41C of the sample loading needle 41 of the puncture unit 40 leaves the reagent box accommodating space 20A. If the reagent box accommodating space 20A is filled with a reagent box 30, the sample loading needle hole 41B is disconnected from the reagent storage space 30A of the reagent box 30. At this time, it is impossible to introduce the required substance into the reagent storage space 30A through the sample loading needle 41 or to lead the substance out from the reagent accommodating space to the end of the sample loading needle 41 away from the puncture end 41C.

[0224] In the reagent storage device 1 of some embodiments, as shown in Figures 4-6, 9-11, and 13-16, the puncture drive unit 50 includes a limiting portion 53, which is configured to limit the movement range of the linkage portion 52 to limit the movement range of the first movable portion 5111. The limiting portion 53 includes one or more limiting structures, at least one limiting structure includes a limiting groove 53A and a limiting surface 53B, the limiting surface 53B is movably located in the limiting groove 53A and is in abutment with the limiting groove 53A, one of the limiting groove 53A and the limiting surface 53B is arranged on the second movable portion 5112, and the other is arranged on the push-pull rod 521.

[0225] The limiting groove 53A and the limiting surface 53B of at least one limiting structure of the limiting portion 53 are arranged on the second movable portion 5112 and the push-pull rod 521 respectively, which is beneficial for accurately determining the moving range of each movable component of the switching portion 51 linked by the push-pull rod 521 and the moving range of the puncture unit 40 driven by the puncture unit 40 by limiting the moving range of the push-pull rod 521, thereby facilitating the synchronous driving of the puncture unit 40 driven by the push-pull rod 521 to quickly and accurately switch between the first puncture working state and the second puncture working state.

[0226] In the reagent storage device 1 of some embodiments, as shown in Figures 4-6, 9-11, and 13-16, the puncture drive unit 50 includes a guide portion 54, which is configured to guide the movement of the linkage portion 52 to guide the movement of the first movable portion 5111. The guide portion 54 includes one or more guide structures, at least one guide structure includes a guide groove 54A and a guide surface 54B, one of the guide groove 54A and the guide surface 54B is fixed relative to the chamber body 11, and the other is arranged on the push-pull rod 521.

[0227] The guide groove 54A and the guide surface 54B of at least one guide structure of the guide part 54 are fixed and arranged on the push-pull rod 521 respectively relative to the magazine body 11, which is conducive to accurately guiding the movement direction of the push-pull rod 521 and guiding the movement of the first movable part 5111 of the switching part 51 linked to the push-pull rod 521, thereby facilitating the synchronous driving of the puncture unit 40 driven by the push-pull rod 521 to quickly and accurately switch between the first puncture working state and the second puncture working state.

[0228] In the reagent storage device 1 of some embodiments, as shown in Figures 23-30 and 32-37, the first movable part 5111 includes a first rotating part 51112, and the first rotating part 51112 is rotatable relative to the warehouse body 11; the second movable part 5112 includes a second rotating part 51122, and the second rotating part 51122 is rotatable relative to the warehouse body 11 and is drivingly connected or drivingly coordinated with the first rotating part 51112. The second rotating part 51122 drives the puncture unit 40 to switch between the first puncture working state and the second puncture working state.

[0229] The first movable portion 5111 includes a first rotating component 51112 , and the second movable portion 5112 includes a second rotating component 51122 , which facilitates the switching portion 51 to achieve its function through the rotating components, requires a smaller operating range, and facilitates reducing the operating space.

[0230] In the reagent storage device 1 of some embodiments, as shown in Figures 23-30 and Figures 32-37, the first rotating component 51112 is a rotating shaft; the second rotating component 51122 includes a cam provided on the rotating shaft, and the cam is pressed and fitted with the puncture unit 40.

[0231] In the reagent storage device 1 of some embodiments, as shown in Figures 23-30 and Figures 32-37, the puncture drive unit 50 also includes a movable connection part 58, which is respectively connected to the cam and the puncture unit 40, and is configured to transmit the movement of the cam to the puncture unit 40 so that the rotation of the cam drives the puncture unit 40 to move.

[0232] Through the movable connection part 58, the cam 40 and the puncture unit 40 can be effectively guaranteed to move synchronously, preventing the puncture unit 40 from getting stuck and failing to fit tightly with the cam 40, thereby ensuring the stability and accuracy of the switching part 51 driving the puncture unit 40, which is beneficial for the puncture unit 40 to switch the working state in a timely and accurate manner.

[0233] In some embodiments of the reagent storage device 1, as shown in Figures 29-30, the movable connection portion 58 includes a movable element 581, a first pin 582, and a second pin 583. The first pin 582 is disposed on the end surface of the cam. The second pin 583 is disposed on the puncture unit 40 in parallel and spaced apart from the first pin 582. The movable element 581 has an arcuate groove 581A. The movable element 581 is mounted on the cam and the puncture unit 40 by the first pin 582 and the second pin 583 cooperating with the arcuate groove 581A. The first pin 582 and the second pin 583 slidably engage with the arcuate groove 581A.

[0234] The movable connection part 58 includes a movable element 581, a first pin 582 and a second pin 583, so that the structure of the movable connection part 58 is simple and the function of making the puncture unit 40 follow the cam can be reliably performed.

[0235] In some embodiments of the reagent storage device 1, as shown in Figures 23-24, 26-29, and 32-37, the puncture drive unit 50 includes a linkage portion 52. The linkage portion 52 is drivingly connected to or drives a first movable portion 5111 of at least two switching portions 51 to synchronize the movement of the puncture units 40 corresponding to the at least two switching portions 51. The linkage portion 52, for example, includes at least one of a belt drive mechanism 522, a chain drive mechanism, a gear drive mechanism, a gear and rack drive mechanism, or a connecting rod mechanism connected between the first rotating components 51112 of the at least two switching portions 51.

[0236] In the embodiment shown in Figures 20 to 37, the linkage unit 52 includes a belt drive mechanism 522 connected between the rotating shafts of the two puncture manipulation units corresponding to the same reagent cartridge storage space 20A. The belt drive mechanism 522 includes pulleys connected to the two rotating shafts and a conveyor belt mounted on the two pulleys. The conveyor belt can be of various types, such as a V-belt, flat belt, synchronous belt, or poly-V belt, and the pulleys and conveyor belt are provided in conjunction with each other.

[0237] In the embodiments shown in Figures 20 to 37, the first rotating element and the corresponding second rotating element are coaxially fixedly connected, for example, the cam is directly fixedly connected to the rotating shaft. In embodiments not shown, the rotational axes of the first rotating element and the corresponding second rotating element can be arranged to be parallel or at an angle via a suitable transmission mechanism, such as a gear transmission mechanism. For example, the rotating shaft and the cam can be driven by a transmission device to drive the cam to rotate via the rotating shaft.

[0238] In addition, in an embodiment not shown, one of the first movable portion 5111 and the second movable portion 5112 can be a translational component and the other a rotational component. The translational component and the rotational component can be converted by an appropriate transmission mechanism, such as a gear and rack mechanism, a cam-and-rod mechanism, a connecting rod mechanism, etc.

[0239] In the reagent storage device 1 of some embodiments, the puncture drive unit 50 further includes an actuating portion 56 , which is drivingly connected to or drivingly engaged with the first movable portion 5111 .

[0240] In the embodiment shown in Figures 1 to 19, the actuating portion 56 includes a handle 561, which is drivingly connected or drivingly engaged with the first movable portion 5111, and the handle 561 is provided on a side of the bin body 11 where the bin door 12 is provided.

[0241] In the embodiment shown in Figures 20 to 37, the actuating portion 56 includes a rotating handle 562, which is drive-connected or drive-coordinated with the first movable portion 5111 (rotating shaft), and the rotating handle 562 is arranged on the side of the warehouse body 11 where the warehouse door 12 is provided.

[0242] In an embodiment not shown, an actuator may also be provided, which is drivingly connected to or drivingly engaged with the first movable portion 5111. The actuator may replace the handle 561 or the rotary handle 562. The actuator may include, for example, an oil cylinder, an air cylinder, a linear motor, a rotary motor, or the like. If it is necessary to convert the direction, speed, or force of the actuator output, an appropriate transmission mechanism may be provided between the actuator and the linkage portion or the switching portion. For example, the conversion between rotational motion and linear motion may be achieved through a gear and rack mechanism, a cam mechanism, or a screw and nut mechanism, and the conversion of speed or force may be achieved through a gear pair, etc.

[0243] In the reagent storage device 1 of some embodiments, as shown in Figures 4-6, 8-10, 14, 23-24, 26-29, 32, and 34-37, the switching unit 51 includes a sample needle driving mechanism 511 and a sample needle resetting mechanism 512. One of the sample needle driving mechanism 511 and the sample needle resetting mechanism 512 is configured to apply a force to the puncture unit 40 to switch the puncture unit 40 from the first puncture operating state to the second puncture operating state; the other of the sample needle driving mechanism 511 and the sample needle resetting mechanism 512 is configured to apply a force to the puncture unit 40 to switch the puncture unit 40 from the second puncture operating state to the first puncture operating state.

[0244] The simultaneous provision of the sample needle driving mechanism 511 and the sample needle resetting mechanism 512 facilitates the rapid and accurate switching of the puncture unit 40 between the first puncture working state and the second puncture working state, thereby facilitating the accurate connection or disconnection of the sample needle 41 and the corresponding reagent storage space 30A in the corresponding puncture working state.

[0245] In the embodiment shown in Figures 1 to 19, the sample needle drive mechanism 511 is configured to apply a force to the puncture unit 40 to switch it from the first puncture operating state to the second puncture operating state. The sample needle reset mechanism 512 is configured to apply a force to the puncture unit 40 to switch it from the second puncture operating state to the first puncture operating state. In the embodiment shown in Figures 20 to 37, the sample needle drive mechanism 511 is configured to apply a force to the puncture unit 40 to switch it from the second puncture operating state to the first puncture operating state. The sample needle reset mechanism 512 is configured to apply a force to the puncture unit 40 to switch it from the first puncture operating state to the second puncture operating state.

[0246] In the reagent storage device 1 of some embodiments, as shown in Figures 4-10, 14, 23-30, and 31-37, the sample needle reset mechanism 512 includes at least one spring 5121; the spring 5121 is located and / or connected between the puncture unit 40 and the reagent kit storage unit 20; or the spring 5121 is located and / or connected between the tank body 11.

[0247] The sample needle reset mechanism 512 includes at least one spring 5121 to facilitate automatic reset of the puncture unit 40 without special operation.

[0248] The type of spring is not limited here, as long as it can achieve the corresponding reset function. For example, it can be a coil spring, and can be set as a tension spring or a compression spring according to the installation position. It can also be a gas spring or a torsion spring, etc.

[0249] In an embodiment not shown in the figure, the sample needle resetting mechanism 512 may include, for example, an electromagnetic drive mechanism, a pneumatic mechanism, or a hydraulic mechanism.

[0250] In some embodiments of the reagent storage device 1 , the reagent storage device 1 includes a plurality of reagent kit storage units 20 , and / or the reagent kit storage unit 20 includes a plurality of reagent kit accommodating spaces 20A.

[0251] The reagent storage device 1 includes a plurality of reagent kit storage units 20 , and the reagent kit storage unit 20 includes a plurality of reagent kit accommodating spaces 20A, which are conducive to the simultaneous management and operation of multiple reagent kits and help expand the functions of the reagent storage device 1 .

[0252] In some embodiments of the reagent storage device 1 , the reagent storage device 1 further includes a heat preservation unit 60 , which is configured to regulate the temperature of the reagent compartment 10 .

[0253] The provision of the heat preservation unit 60 facilitates the storage of reagents at a desired temperature, thereby facilitating the assurance of reagent quality.

[0254] In the reagent storage device 1 of some embodiments, as shown in FIG. 2 , FIG. 4 - FIG. 8 , FIG. 21 , FIG. 23 , and FIG. 26 - FIG. 28 , the heat preservation unit 60 includes a refrigerant circulation system 61 .

[0255] The refrigerant circulation system 61 includes a compressor 612, a first heat exchanger 613, a throttling device, and a second heat exchanger 615, which are sequentially connected via a refrigerant pipeline 611. To improve the heat exchange capacity of the first heat exchanger 613 and the second heat exchanger 615, a first fan 616 and a second fan 617 are provided, respectively. A four-way valve for switching the direction of refrigerant flow may also be provided, enabling the refrigerant circulation system 61 to have both cooling and heating functions, thereby facilitating maintaining the internal storage space of the reagent compartment 10 of the reagent storage device 1 at a temperature below or above the ambient temperature.

[0256] As shown in Figures 1, 3-6, 8-10, 14, 19-20, 22-29, 32, and 34-35, in the reagent storage device 1 of some embodiments, the reagent storage device 1 includes a reagent kit 30, the reagent kit 30 includes a reagent storage space 30A, and the reagent kit accommodating space 20A of the reagent storage device 1 is used to place the reagent kit 30; in the first puncture working state of the puncture unit 40, the sample loading needle hole 41B is connected to the reagent storage space 30A of the reagent kit 30 placed in the reagent kit accommodating space 20A, and in the second puncture working state of the puncture unit 40, the sample loading needle hole 41B is disconnected from the reagent storage space 30A of the reagent kit 30 placed in the reagent kit accommodating space 20A.

[0257] In the reagent storage device 1 of some embodiments, as shown in Figures 3-4, 6, 9, 14, 19, 22, 25-26, and 34, the reagent kit 30 has a weak portion 301 corresponding to the puncture end 41C of the sample loading needle 41. In the first puncture working state of the puncture unit 40, the puncture end 41C of the sample loading needle 41 enters the reagent storage space 30A by puncturing the weak portion 301 to realize the connection between the sample loading needle hole 41B of the sample loading needle 41 and the reagent storage space 30A of the reagent kit 30.

[0258] To facilitate insertion of the sample needle 41 into the reagent cartridge body 31 and communication with the reagent storage space 30A, a weakened portion 301 may be provided at the portion of the reagent cartridge body 31 where the sample needle mates, facilitating insertion of the reagent needle. The weakened portion 301 may, for example, be thinner than the walls of the reagent cartridge body 31 other than the weakened portion 301, or may be made of a different material than the walls of the reagent cartridge body 31 other than the weakened portion 301. The weakened portion 301 may be easily replaceable to facilitate reuse of the reagent cartridge 30. For example, an opening and a covering may be provided at the portion of the reagent cartridge body 31 corresponding to the reagent needle. The weakened portion 301 may be the covering itself or a portion of the covering. The covering may, for example, be a film or a cap.

[0259] As shown in Figures 1, 3-6, and 7, in some embodiments of the reagent storage device 1, the reagent storage device 1 also includes a base plate 70, which is located in the reagent compartment 10 and is installed on the bottom wall of the compartment body 11, and the reagent kit storage unit 20 and / or the puncture unit 40 is installed on the base plate 70.

[0260] In the embodiment shown in FIG. 1 to FIG. 19 , components of the reagent storage device 1 located inside the reagent compartment 10 , such as the reagent kit storage unit 20 , the puncture unit 40 and the puncture drive unit 50 , are all mounted on the bottom plate 70 .

[0261] Different from the embodiment shown in Figures 1 to 19, in the embodiment shown in Figures 20 to 37, the components of the reagent storage device 1 located inside the reagent chamber 10, such as the reagent chamber storage unit 20, the puncture unit 40 and the puncture drive unit 50 are all installed on the bottom wall of the chamber body 11 of the reagent chamber 10, and no bottom plate is provided.

[0262] A bottom plate 70 is provided in the reagent chamber 10 to facilitate the assembly of the partial structures of the reagent storage device 1 and to fit the entire device into the internal accommodation space of the reagent chamber 10 , thereby facilitating quick disassembly and maintenance.

[0263] As shown in FIG38 , an embodiment of the present disclosure further provides a reagent operating system, comprising the reagent storage device 1 of the aforementioned embodiment of the present disclosure. The reagent operating system further comprises at least one of a reagent receiving portion 2, a cleaning liquid delivery portion 3, and a gas communication portion 4. The reagent receiving portion 2 is in communication with the internal channel 41A of the sample injection needle 41 of at least one puncture unit 40. The cleaning liquid delivery portion 3 is in communication with the internal channel 41A of the sample injection needle 41 of at least one puncture unit 40. The gas communication portion 4 is in communication with the internal channel 41A of the sample injection needle 41 of at least one puncture unit 40.

[0264] The reagent operating system of the disclosed embodiment is coupled with the sample injection needle 41 of the puncture unit 40 of the reagent storage device 1 through the reagent receiving part 2 and / or the cleaning liquid delivery part 3 and / or the gas connecting part 4, which can realize the functions of reagent sampling, output and / or delivery of cleaning liquid to the reagent storage space 30A to clean the sample injection needle 41 and / or connect the reagent storage space 30A with the external gas so that the reagent or cleaning liquid can smoothly enter or flow out of the reagent storage space 30A. The reagent receiving part 2 is provided to introduce the reagent in the reagent kit 30 into the reagent receiving part 2 to realize reagent transfer. The cleaning liquid delivery part 3 is provided to introduce the cleaning liquid into the reagent kit 30 to clean the sample injection needle 41 that has been in contact with the reagent, thereby realizing the cleaning of the sample injection needle 41. The gas connecting part 4 is provided to introduce gas into the reagent storage space 30A of the reagent kit 30, thereby facilitating the control of the pressure of the reagent storage space 30A, thereby facilitating the control of the speed at which the reagent flows out.

[0265] In some embodiments of the reagent operating system, the reagent operating system includes a reagent receiving part 2 and a cleaning liquid delivery part 3, and the reagent receiving part 2 and the cleaning liquid delivery part 3 are respectively connected to the internal channel 41A of the sample injection needle 41 of different puncture units 40; and / or the reagent operating system includes a cleaning liquid delivery part 3 and a gas connecting part 4, and the cleaning liquid delivery part 3 and the gas connecting part 4 are connected to the internal channel 41A of the sample injection needle 41 of the same puncture unit 40 at different time periods.

[0266] In some embodiments of the reagent operating system, the reagent operating system includes a reagent receiving section 2 and a cleaning liquid delivery section 3. The puncture end 41C of the sample injection needle 41 of the puncture unit 40 connected to the reagent receiving section 2 is located outside or below the bottom of the corresponding reagent cartridge accommodating space 20A; and the puncture end 41C of the sample injection needle 41 of the puncture unit 40 connected to the cleaning liquid delivery section 3 is located outside or above the top of the corresponding reagent cartridge accommodating space 20A.

[0267] The above arrangement facilitates the sample introduction needle 41 for extracting the reagent to penetrate into the reagent box 30 at a shallow depth, thereby emptying the reagent in the corresponding reagent storage space 30A and using less cleaning liquid to clean the sample introduction needle 41 for extracting the reagent, while the sample introduction needle 41 for introducing the cleaning liquid will not come into contact with the reagent and will not be contaminated by the reagent.

[0268] In the reagent operating system of some embodiments, the reagent receiving part 2 is connected to the sample adding needle 41 of at least one puncture unit 40 through a connecting tube having a flexible tube section or a telescopic tube section; and / or the cleaning liquid delivery part 3 is connected to the sample adding needle 41 of at least one puncture unit 40 through a connecting tube having a flexible tube section or a telescopic tube section; and / or the gas connecting part 4 is connected to the sample adding needle 41 of at least one puncture unit 40 through a connecting tube having a flexible tube section or a telescopic tube section.

[0269] The end of the sampling needle 41 away from the puncture needle hole 41B can be connected to one end of a connecting tube including a flexible tube segment or a telescopic tube segment, and the other end of the connecting tube is connected to the perforation on the warehouse body 11 or passes through the perforation on the warehouse body 11, and the reagent receiving part 2 or the cleaning liquid delivery part 3 or the gas connecting part 4 located outside the reagent storage device 1 can be connected to the perforation or the other end of the connecting tube, thereby connecting to the sampling needle 41. Due to the flexibility of the connecting tube including the flexible tube segment or the telescopic performance of the connecting tube including the telescopic tube segment, the position change of the sampling needle 41 caused by the switching of the working position of the puncture unit 40 does not affect the connection with the reagent receiving part 2 or the cleaning liquid delivery part 3 or the gas connecting part 4 and the second end of the connecting tube or does not affect the connection with the perforation on the warehouse body 11.

[0270] In the reagent operating system of some embodiments, the reagent receiving part 2 is connected to the sample loading needle 41 of at least one puncture unit 40 through a connecting tube that passes through the warehouse body 11 and is sealed between the warehouse body 11; and / or the cleaning liquid delivery part 3 is connected to the sample loading needle 41 of at least one puncture unit 40 through a connecting tube that passes through the warehouse body 11 and is sealed between the warehouse body 11; and / or the gas connecting part 4 is connected to the sample loading needle 41 of at least one puncture unit 40 through a connecting tube that passes through the warehouse body 11 and is sealed between the warehouse body 11.

[0271] Since the connecting tube connecting the reagent receiving part 2 and / or the cleaning liquid delivery part 3 and / or the gas connecting part 4 with the sample injection needle 41 is sealed with the chamber body 11, external air can be better prevented from entering the reagent chamber 10, thereby preventing air from entering the internal holding space of the reagent chamber 10 through the gap between the connecting tube and the chamber body 11 to form condensed water and then carrying dust and impurities into the test kit to contaminate the reagent.

[0272] The embodiments of the present disclosure are described in detail below with reference to FIG. 1 to FIG. 38 .

[0273] In the description of the following embodiments of the present disclosure: "front" refers to the side where the compartment door is located, corresponding to the X direction in Figures 1 and 20, that is, corresponding to the aforementioned first direction, and "rear" refers to the side opposite to the "front"; "up" and "down" refer to the up and down directions when the reagent storage device 1 is normally placed, "up" corresponds to the Z direction in Figures 1 and 20, that is, corresponding to the aforementioned second direction, and "up" and "down" are also expressed as "top" and "bottom" respectively in the following description; "left" and "right" refer to the left and right directions when observing from "front" to "rear", and "right" corresponds to the Y direction in Figure 1, which can also be called the third direction.

[0274] Figures 1 to 19 illustrate a reagent storage device 1 according to an embodiment of the present disclosure. In the embodiment shown in Figures 1 to 19 , the reagent storage device 1 includes a reagent compartment 10, a reagent cartridge storage unit 20, a reagent cartridge 30, a puncture unit 40, a puncture drive unit 50, a heat preservation unit 60, and a bottom plate 70.

[0275] The reagent chamber 10 includes a chamber body 11 and a chamber door 12 for enclosing the chamber body 11. The chamber body 11 is a cubical shape with an opening toward the front side of the chamber body 11. The chamber body 11 defines an internal storage space for the reagent chamber 1. When the chamber door 12 is closed, the internal storage space is sealed. The chamber door 12 is hingedly connected to the front end of the right side wall of the chamber body 11.

[0276] The reagent cartridge storage unit 20, reagent cartridge 30, puncture unit 40, puncture drive unit 50, heat preservation unit 60, and bottom plate 70 are all located within the internal storage space. The bottom plate 70 is mounted on the bottom wall of the chamber body 11. The reagent cartridge storage unit 20, reagent cartridge 30, puncture unit 40, puncture drive unit 50, and heat preservation unit 60 are all mounted on the bottom plate 70.

[0277] The reagent storage device 1 includes two reagent kit storage units 20 arranged side by side. Each reagent kit storage unit 20 includes a reagent kit accommodating space 20A, and the reagent kit accommodating space 20A is configured to place a reagent kit 30 having a reagent storage space 30A.

[0278] Each reagent box storage unit 20 includes two parallel, spaced-apart upper and lower square reagent box protection plates serving as reagent box protection portions 21, and four connecting rods 22. The reagent box protection plates have puncture end avoidance openings 21A for avoiding the puncture end 41C of the sample injection needle 41. A connecting rod 22 is provided at each of the four corners of the upper and lower reagent box protection plates, and each connecting rod 22 is fixedly connected to the upper and lower reagent box protection plates. Each connecting rod 22 passes through the upper and lower reagent box protection plates. The upper and lower ends of the connecting rod 22 are located above and below the upper and lower reagent box protection plates, respectively. The bottom end of the connecting rod 22 is fixedly connected to the base plate 70. The bottom end of the connecting rod 22 is fixedly connected to the base plate 70 by, for example, welding, threaded connection, or connection via a connector. The portion of the connecting rod 22 located between the two reagent box protection plates is a square rod segment with a square cross-section, and the portions of the connecting rod 22 located above and below the two reagent box protection plates are circular rod segments. The space defined by the upper and lower reagent box protection plates and the four connecting rods 22 is the reagent box accommodating space 20A. In an embodiment not shown, the cross-sectional shape of the connecting rods 22 can be square or circular from top to bottom.

[0279] The reagent kit 30 includes a plurality of reagent storage spaces 30A. The reagent kit 30 includes a plurality of reagent kit bodies 31 , wherein each reagent kit body 31 includes a single reagent storage space 30A.

[0280] As shown in Figure 19, the reagent kit 30 also includes a mounting frame 32 and a cover plate 33. The mounting frame 32 comprises a square frame body and multiple partitions. The partitions divide the space within the frame body into multiple independent areas corresponding to the multiple reagent kit bodies 31. Each reagent kit body 31 has an open top and is mounted on the lower portion of the mounting frame 32. It is sealed to the partitions of the corresponding independent area and the top of the frame body. The cover plate 33 covers the mounting frame 32 and is sealed to the frame body and the top of the partitions. The cover plate 33 is provided with multiple weak points 301 corresponding to each independent area and the corresponding reagent kit body 31. The bottom wall of each reagent kit body 31 has a hole, and each hole is provided with a plug 34 that plugs into the hole. The plug 34 is provided with a weak point 301. When the reagent kit 30 is installed in the reagent kit storage space 20A, each weak point 301 is opposite the corresponding sample injection needle 41.

[0281] The reagent storage device 1 includes four puncture units 40, two of which are provided for each reagent cartridge storage unit 20. Of the two puncture units 40 provided for the same reagent cartridge storage space 20A, the puncture end 41C of the sample loading needle 41 of one puncture unit 40 is located below the corresponding reagent cartridge storage space 20A, while the puncture end 41C of the sample loading needle 41 of the other puncture unit 40 is located above the corresponding reagent cartridge storage space 20A.

[0282] The puncture unit 40 includes a sample needle mounting portion 42 and a plurality of sample needles 41 fixed to the sample needle mounting portion 42. The sample needle mounting portion 42 is a mounting plate.

[0283] The sample addition needle 41 has an internal channel 41A and a puncture end 41C. The puncture end 41C is provided with a sample addition needle hole 41B communicating with the internal channel 41A.

[0284] The puncture unit 40 is movably disposed relative to the reagent cartridge storage unit 20 and has a first puncture operating state and a second puncture operating state. When the reagent cartridge 30 is placed in the reagent cartridge accommodating space 20A, in the first puncture operating state, the sample needle pinhole 41B communicates with the reagent cartridge storage space 30A. In the second puncture operating state, the sample needle pinhole 41B is disconnected from the reagent cartridge storage space 30A.

[0285] Among them, the puncture end 41C of the sample injection needle 41 of the puncture unit 40 located below the reagent kit storage space 20A is located below the corresponding reagent kit storage space 20A. The puncture unit 40 located below is used to extract the reagent from the reagent kit 30. The puncture end 41C of the sample injection needle 41 of the puncture unit 40 located above the same reagent kit storage space 20A is located above the corresponding reagent kit storage space 20A. The puncture unit 40 located above is used to connect with the gas when the puncture unit 40 located below extracts the reagent from the reagent kit 30 to facilitate the extraction of the reagent. It is also used to pass a cleaning fluid into the reagent storage space 30A to clean the sample injection needle 41 of the puncture unit 40 located below after the puncture unit 40 located below has extracted the reagent from the reagent kit 30.

[0286] As shown in Figures 17 and 18, the sample needle 41 of the puncture unit 40 includes a sample needle tube 411 and a sample needle tip 412. An internal channel 41A is located within the sample needle tube 411. The sample needle tip 412 is located at the puncture end 41C of the sample needle 41 and is connected to one end of the sample needle tube 411. The sample needle tip 412 is a cone with a cross-section that gradually decreases from the sample needle tube 411 toward the side away from the sample needle tube 411. The sample needle hole 41B is located on the side wall of the sample needle tube 411 near the sample needle tip 412.

[0287] The sample needle tube 411 includes a first straight tube section 4111, a curved tube section 4112, and a second straight tube section 4113. The curved tube section 4112 is a flexible tube section. The first straight tube section 4111 extends along the wall surface of the chamber body 11 in a first direction X. The second straight tube section 4113 extends from one side of the chamber wall surface of the chamber body 11 toward the reagent cartridge storage space 20A, that is, along a second direction Z. One end of the second straight tube section 4113 is connected to one end of the first straight tube section 4111 via a curved tube section 4112, and the sample needle tip 412 is connected to the other end of the second straight tube section 4113. Each sample needle 41 is mounted on the sample needle mounting portion 42 via its fixed connection portion 413. The fixed connection portion 413 and the sample needle mounting portion 42 are connected by, for example, a threaded connection or an interference fit.

[0288] The reagent storage device 1 includes two puncture drive units 50. Each puncture drive unit 50 is correspondingly provided to a reagent reagent storage unit 20 and is drivingly connected to the two puncture units 40 corresponding to the corresponding reagent reagent storage unit 20.

[0289] Each puncture drive unit 50 includes a switching portion 51 , a linkage portion 52 , a limiting portion 53 , a guide portion 54 , a positioning portion 55 and an actuating portion 56 .

[0290] Each puncture drive unit 50 includes two switching sections 51 corresponding to the two puncture units 40. Each switching section 51 is drivingly connected to or in conjunction with the corresponding puncture unit 40 and is configured to drive the puncture unit 40 to switch between a first puncture operating state and a second puncture operating state. The two switching sections 51 are arranged in a linkage manner via a linkage section 52 to simultaneously drive the two puncture units 40 corresponding to the same reagent cartridge storage space 20A, so that the two puncture units 40 synchronously switch from the first puncture operating state to the second puncture operating state, or from the second puncture operating state to the first puncture operating state.

[0291] In this embodiment, multiple sample needles 41 of each puncture unit 42 are installed on the sample needle mounting portion 42, and the switching portion 51 is drivingly connected or drivingly coordinated with the sample needle mounting portion 42 of the puncture unit 40 to drive the multiple sample needles 41 to move synchronously.

[0292] The switching unit 51 includes a sample needle driving mechanism 511 and a sample needle resetting mechanism 512. The sample needle driving mechanism 511 applies a force to the puncture unit 40 to switch it from the first puncture operating state to the second puncture operating state. The sample needle resetting mechanism 512 applies a force to the puncture unit 40 to switch it from the second puncture operating state to the first puncture operating state.

[0293] The sample needle drive mechanism 511 includes a first movable portion 5111 and a second movable portion 5112. The first movable portion 5111 has a first drive operating position and a second drive operating position. The second movable portion 5112 is drivingly connected or drivingly engaged with the first movable portion 5111 and the puncture unit 40. Referring to Figures 14 to 16 , when the first movable portion 5111 is in its first drive operating position, the puncture unit 40 is in its first puncture operating state. Referring to Figures 4-6 and 8-11 , when the first movable portion 5111 is in its second drive operating position, the puncture unit 40 is in its second puncture operating state.

[0294] The first movable portion 5111 of each sample loading needle drive mechanism 511 includes four first translation components 51111, two of which are positioned on each of the front and rear sides of the reagent cartridge storage unit 20. The two first translation components 51111 on each side of the reagent cartridge storage unit 20 are spaced apart along the front-to-back direction. Each first translation component 51111 is reciprocally movable relative to the cartridge body 11 along a first direction X. Each first translation component 51111 is provided with a driving surface 51111A that is inclined along the first direction X toward a second direction Z that is perpendicular to the first direction X.

[0295] The second movable portion 5112 of each sample needle drive mechanism 511 includes two second translation components 51121, one located on each left and right side of the reagent cartridge storage unit 20. Each second translation component 51121 is fixedly connected to the corresponding sample needle mounting portion 42, thereby being fixedly positioned relative to the sample needle 41. Each second translation component 51121 is reciprocally movable relative to the chamber body 11 along the second direction Z. Each second translation component 51121 is provided with two mating surfaces 51121A corresponding to the two driving surfaces 51111A of the first translation component 51111 on the corresponding side. The mating surfaces 51121A are inclined along the first direction X toward the second direction Z. Changing the position of the first translation component 51111 in the first direction X changes the mating position of the driving surfaces 51111A with the corresponding mating surfaces 51121A, thereby changing the position of the second translation component 51121 in the second direction Z.

[0296] Each injection needle reset mechanism 512 includes four springs 5121, which are located at the four corners of the reagent cartridge storage unit 20. Each spring 5121 is mounted on the connecting rod 22 at the corresponding corner. The corresponding end of the connecting rod 22 passes through the injection needle mounting portion 42, with a portion of the rod extending outside the injection needle mounting portion 42. The spring 5121 is mounted on the rod portion outside the injection needle mounting portion 42. One end of the spring 5121 abuts the corresponding injection needle mounting portion 42, and the other end presses against a spring seat 5122, which is fixed to the end of the connecting rod 22 via a threaded connector. Each spring 5121 is a compression spring, which applies a force to the sample needle mounting part 42 to make it toward the side of the reagent reagent storage unit 20, and also applies a force to the second translation component 51121 to make it toward the push-pull rod 521 through the sample needle mounting part 42. Therefore, when the push-pull rod 521 is in the rearward extreme position, each driving surface 51111A and the corresponding matching surface 51121A are in a convex-concave matching state, which is beneficial for the sample needle mounting part 42 and the sample needle 421 thereon to reach the specified position when the sample needle mounting part 42 is in the first puncture working state of the puncture unit 40, thereby preventing the sample needle 421 from being unable to effectively communicate with the corresponding reagent storage space 30A.

[0297] The linkage portion 52 is drivingly connected or engaged with the two switching portions 51 to synchronize the movement of the corresponding puncture units 40. The linkage portion 52 includes two push-pull rods 521 extending along the first direction X. The two push-pull rods 521 are located on the left and right sides of the reagent cartridge storage unit 20, respectively. The first translation components 51111 of the two puncture units 40 are secured to the push-pull rods 521 on the same side. A driving surface 51111A is provided on the side of the push-pull rods 521 proximate to the corresponding second translation component 51121. The second translation component 51121 includes a pressure plate arranged along the second direction Z, with a mating surface 51121A provided at the end of the pressure plate proximate to the corresponding first translation component 51111.

[0298] The first translation component 51111 is a protrusion provided on the push-pull rod 521, and the driving surface 51111A is an arcuate surface of the protrusion protruding from the push-pull rod 521 toward the side of the pressure plate. Correspondingly, the mating surface 51121A includes an arcuate surface provided on the end of the pressure plate toward the side of the push-pull rod 521 and protruding toward the side away from the push-pull rod 521.

[0299] As the push-pull rod 521 translates in the front-to-back direction, when the driving surface 51111A on the push-pull rod 521 is located in the mating surface 51121A provided on the pressure plate, that is, when the two arcuate surfaces serving as the driving surface 51111A and the mating surface 51121A respectively cooperate with each other, the first translation component 51111 is in its first driving working position (as shown in Figures 14-16). At this time, the puncture end 41C of the sample loading needle 41 of the puncture unit 40 enters the reagent storage space 20A. If the reagent cartridge 30 is contained in the reagent cartridge 20A, the sample loading needle tip 412 penetrates the corresponding reagent cartridge body 31, and the sample loading needle hole 41B is connected to the corresponding reagent storage space 30A of the reagent cartridge body 31, so that the required substance can be introduced into the reagent storage space 30A through the sample loading needle 41 or the substance can be drawn out from the reagent storage space 20A to the end of the sample loading needle 41 away from the puncture end 41C.

[0300] As the push-pull rod 521 translates in the front-to-back direction, when the arcuate surface on the push-pull rod 521 leaves the arcuate surface of the pressure plate, that is, when the two arcuate surfaces release the convex-concave fit, the first translation component 51111 is in its second driving working position (as shown in Figures 4-6, 9-11, and 12). At this time, the puncture end 41C of the sample loading needle 41 of the puncture unit 40 leaves the reagent box accommodating space 20A. If the reagent box accommodating space 20A is filled with a reagent box 30, the sample loading needle tip 412 is separated from the corresponding reagent box body 31, and the sample loading needle hole 41B is disconnected from the reagent storage space 30A corresponding to the reagent box body 31. At this time, it is impossible to introduce the required substance into the reagent storage space 30A through the sample loading needle 41 or to lead the substance out from the reagent accommodating space to the end of the sample loading needle 41 away from the puncture end 41C.

[0301] The limiting portion 53 is configured to limit the range of motion of the first movable portion 5111 and the second movable portion 5112. In this embodiment, the limiting portion 53 limits the range of motion of the first movable portion 5111 and the second movable portion 5112 by limiting the range of motion of the push-pull rod 521 as the linkage portion 52.

[0302] As shown in Figures 4-6, 9-11, and 13-16, the limiting portion 53 of each puncture drive unit 50 includes four limiting structures. These four limiting structures are grouped in pairs, with each pair located on the upper and lower sides of a push-pull rod 521. Each limiting structure includes a limiting groove 53A and a limiting surface 53B. The limiting surface 53B is movably positioned within and abuts the limiting groove 53A. The limiting groove 53A is provided on the second movable portion 5112, which in this embodiment is provided on the pressure plate, while the limiting surface 53B is provided on the push-pull rod 521, which serves as the linkage portion 52. Specifically, the push-pull rod 521 is provided with a limiting protrusion 531 facing the pressure plate, and the limiting surface 53B is a portion of the surface of the limiting protrusion 531.

[0303] As shown in Figures 4-6, 9-11, and 13-16, each push-pull rod 521 is provided with a stopper protrusion 531 on its upper and lower sides. The stopper protrusion 531 is hook-shaped, comprising a main body connected to the push-pull rod 521 and a hook portion protruding from the side away from the push-pull rod 521 and facing the first direction X. The surface of the hook portion facing the push-pull rod 521 slopes outward from the main body in a direction from the side close to the push-pull rod 521 to the side away from the push-pull rod 521. This surface of the hook portion facing the push-pull rod 521 forms a portion of the stopper surface 53B. The surface of the main body opposite the hook portion forms the other portion of the stopper surface. A limiting groove 53A is provided on one side of the pressure plate corresponding to each limiting protrusion 531. Limiting groove 53A comprises a first groove section proximal to the push-pull rod 521 and a second groove section connected to the first groove section and located distal to the push-pull rod 521. The width of the second groove section along the first direction X is greater than the width of the first groove section along the first direction X. The first and second groove sections are connected by a stepped surface. The limiting protrusion 531 is located within the limiting groove 53A, and there is a margin of movement within the limiting groove 53A along the first direction X.

[0304] When the push-pull rod 521 moves from the front to the rear, the hook portion, driven by the push-pull rod 521, approaches and eventually abuts against the angle between the step surface on the rear side of the limiting groove 53A and the first groove section. After abutting, the limiting structure 53 prevents the push-pull rod 521 from moving further backward, thereby limiting the rearward movement of the first translation component 51111. In addition, the hook portion limits the movement of the second translation component 51121 away from the push-pull rod, thereby also limiting the upward movement of the second translation component 51121.

[0305] When the push-pull rod 521 moves from the rear side to the front side, the hook portion, driven by the push-pull rod 521, gradually moves away from the stepped surface of the limiting groove 53A on the side of the push-pull rod 521, thereby releasing the restriction on the movement of the second translation member 51121 away from the push-pull rod. Driven by the push-pull rod 521 and the first translation member 51111 thereon, the second translation member 51121 can move away from the push-pull rod 521 along the second direction Z. As the push-pull rod 521 continues to move forward, the surface of the main portion of the limiting protrusion 531 opposite the hook portion abuts against the right side wall of the first groove section of the limiting groove 53A. After the abutment, the limiting structure 53 prevents the push-pull rod 521 from continuing to move rightward, thereby limiting the forward movement of the first translation member 51111 by limiting the push-pull rod 521.

[0306] 4-6 , 9-11 , and 13-16 , the guide portion 54 is configured to guide the movement of the first movable portion 5111 along the first direction X. In this embodiment, the guide portion 54 guides the movement of the first movable portion 5111 by guiding the movement of the push-pull rod 521 serving as the linkage portion 52 .

[0307] As shown in Figures 4-6, 9-11, and 13-16, the guide portion 54 includes a plurality of guide structures, each guide structure including a guide groove 54A and a corresponding guide surface 54B, the guide surface 54B slidingly cooperates with the corresponding guide groove 54A, the guide surface 54B is fixed relative to the bin body 11, and the guide groove 54A is fixed relative to the first movable portion 5111. For example, in this embodiment, the guide groove 54A is arranged on the push-pull rod 521.

[0308] As shown in Figures 4-6, 9-11, and 13-16, the puncture drive unit 50 is provided with two guide structures at each of the front and rear ends of each push-pull rod 521. Of the two guide structures at each end of each push-pull rod 521, one guide structure has a guide groove 54A disposed on the push-pull rod 521 and extending in the second direction Z. The support column 22 of the reagent cartridge storage unit 20, which extends in the second direction Z, passes through this guide groove 54A. The surface of the support column 22, which extends in the third direction Y, slidably engages with the guide groove 54A and has a margin of motion within the guide groove 54A along the first direction X. Of the two guide structures at each end of each push-pull rod 521, the other guide structure has a guide groove 54A disposed on the push-pull rod 521 and extending in the third direction Y. The corresponding guide surface 54B is disposed on the guide pin 541. The axial direction of the guide pin 541 is the third direction Y. The guide pin 541 is disposed in the corresponding guide slot 54A, slidingly engaged with the guide slot 54A, and has a movable margin in the guide slot 54A along the first direction X.

[0309] In the embodiment shown in Figures 1 to 19, the linkage portion 52 is movably mounted on the support column 22 via a guide pin 541. Furthermore, by properly setting the length and position of the guide slot 54A corresponding to the guide pin 541, the front and rear limit positions of the relative movement of the guide pin 541 within the guide slot 54A precisely correspond to the second and first drive operating positions of the first translation component 51111 on the push-pull rod 521, respectively. Thus, the guide pin 541 and the corresponding guide slot 54A can also serve to limit the movement of the first movable portion 5111 along the first direction X. Similarly, the connecting rod 22 and the corresponding guide slot 54A can also serve to limit the movement of the first movable portion 5111 along the first direction X by properly setting the length and position of the guide slot 54A.

[0310] As shown in Figures 4-6, 9-12, and 14-15, the positioning portion 55 has a positioning state that keeps the puncture unit 40 in the second puncture working state and an avoidance state that prevents interference with the puncture unit 40 from switching the working position. The positioning portion 55 is movably arranged relative to the chamber body 11 to switch between the avoidance state and the positioning state.

[0311] The positioning portion 55 switches between its positioning state and its avoidance state by locking and unlocking the position of the second movable portion 5112. When the first movable portion 5111 is in its second driving working position, the positioning portion 55 is in the positioning state. When the first movable portion 5111 switches between the first driving working position and the second driving working position, the positioning portion 55 is in the avoidance state.

[0312] The positioning portion 55 is driven in conjunction with the reagent cartridge 30 to switch between a retracted state and a positioned state driven by the reagent cartridge 30. When the reagent cartridge 30 is placed in the reagent cartridge accommodating space 20A, the positioning portion 55 is in the retracted state. When the reagent cartridge 30 is removed from the reagent cartridge accommodating space 20A, the positioning portion 55 is in the positioned state.

[0313] As shown in Figure 12, the positioning portion 55 includes a slider 551 and a slider reset mechanism 552. The slider 551 is movably mounted within the chamber body 11 relative to the chamber body 11 and includes a positioning surface 5511D. The slider 551 is driven in conjunction with the reagent cartridge 30. In the avoidance state of the positioning portion 55, the slider 551 is in a avoidance position where the positioning surface 5511D is separated from the second movable portion 5112. The slider reset mechanism 552 is in a force-storing state. In the positioning state of the positioning portion 55, the slider 551 is in a positioning position where the positioning surface 5511D abuts the second movable portion 5112, and the slider reset mechanism 552 is in a force-releasing state. In this embodiment, the positioning portion 55 of each puncture drive unit 50 includes two positioning mechanisms, which are respectively located at the rear of the left and right sides of the reagent cartridge storage unit 20, and each positioning mechanism is mounted on the support column 22 on the corresponding side.

[0314] The structure of the positioning mechanism is described below with reference to Figures 11 and 12. As shown in Figures 11 and 12, the positioning mechanism includes the aforementioned slider 551, a slider reset mechanism 552, and a slider mounting pin 553.

[0315] As shown in FIG12 , the slider 551 includes two first blocks 5511 spaced apart and arranged in parallel, and a second block 5512 connected at right angles to the two first blocks 5511. The slider 551 is movably mounted on the support column 22.

[0316] The rear section of the push-pull rod 521 is located in the gap between the two first blocks 5511, and the push-pull rod 521 slidably engages with the slider 551. Therefore, the push-pull rod 521 defines the position of the slider 551 along the second direction Z and its movement along the first direction X. Each first block 5511 of the slider 551 is also provided with a first slider groove 5511A and a second slider groove 5511B. The first slider groove 5511B is slotted in the second direction Z. The corresponding support column 22 penetrates into the first slider groove 5511B of the two first blocks 5511, slidingly connected thereto and having a play in the first slider groove 5511B along the first direction X. The second slider groove 5511B is slotted in the third direction Y. Two slider mounting pins 553 are provided corresponding to the second slider grooves 5511B of the two first blocks 5511. The slider mounting pin 553 has an axial direction in the third direction Y. It is mounted on the support column 22 and located in the second slider groove 5511B. The slider mounting pin 553 slidably engages with the second slider groove 5511B and has a movable margin along the first direction X. Thus, the slider 551 is movably mounted on the support column 22 via the slider mounting pin 553 and the push-pull rod 521.

[0317] In this embodiment, the front limit position and the rear limit position of the slider mounting pin 553 in the second slider groove 5511B determine the limit positions of the slider 551 .

[0318] In the embodiment shown in Figures 1 to 19, the slider reset mechanism 552 includes a spring located within the slider 551, with its ends respectively pressing against the slider 511 and the support column 22. In this embodiment, a spring mounting hole 5511C extending along the first direction X is provided within each first block 5511, and a spring is disposed within the spring mounting hole 5511C. The spring mounting hole 5511C communicates with the first slider groove 5511A, allowing one end of the spring to abut against the support column 22 to exert force on the support column 22. To facilitate spring installation and adjustment of the spring's elastic force, a threaded hole can be provided at the end of the spring mounting hole 5511C, and a screw that mates with the threaded hole can be disposed within the threaded hole. The screw abuts against one end of the spring, and when the position of the screw within the threaded hole is adjusted, the spring's elastic force is adjusted accordingly.

[0319] The positioning surface 5511D is provided at one end of each first block 5511 away from the second block 5112. The end of the first block 5511 away from the second block 5512 includes a step surface facing the corresponding puncture unit 40, and the step surface forms the positioning surface 5511D.

[0320] The second block 5512 is opposite to the rear portion of the reagent accommodating space 20A and is located within the reagent accommodating space 20A when the slider reset mechanism 552 is in the released state. As the reagent accommodating space 20A is gradually pushed from front to back, it gradually approaches and contacts the second block 5512. After contact, the second block 5512 gradually moves backward under the push of the reagent accommodating space 20A. During the backward movement of the second block 5512, the positioning surface 5511D of the slider 551 also moves backward, and the overlap with the second movable portion 5112 in the first direction X gradually decreases until the slider 551 separates and is in the avoidance position, as shown in Figure 14. At this time, the slider reset mechanism 552 is in the stored state. In the stored state, the slider reset mechanism 552, like a spring, is subjected to the maximum force.

[0321] Before the reagent box 30 is taken out from the reagent box accommodating space 20A, the push-pull rod 521 needs to be pulled forward so that the first translation component 51111 arranged on the push-pull rod 521 moves forward accordingly, and the upper and lower second translation components 51121 on the left and the upper and lower second translation components 51121 on the right move upward to both sides respectively, so that each puncture unit 40 is in the second puncture working state. When the reagent box 30 is taken out from the reagent box accommodating space 20A, it gradually moves forward. Due to the action of the spring of the positioning part 55, the second block 5512 and the slider 551 follow the reagent box 30 to move forward until they are limited by the slider mounting pin 553 and the second slider groove 5511B, and the slider 551 no longer moves with the reagent box 30. At this time, the slider reset mechanism 552 of the positioning part 55 is in a release state. In the release state, the slider reset mechanism 552 is subjected to the minimum force like the spring.

[0322] In the embodiments shown in Figures 1 to 19, the actuating portion 56 of each puncture drive unit 50 includes a handle 561, which is drive-connected or drive-coordinated with the first movable portion 5111 of the switching portion 51. The handle 561 is arranged on the side of the chamber body 11 where the chamber door 12 is provided, that is, on the front side.

[0323] The handle 561 is a U-shaped structure, comprising two parallel, spaced-apart first handle rods and a second handle rod connecting the two first handle rods. The two first handle rods extend vertically and are positioned on either side of the reagent container space 20A, with the free end of each first handle rod fixedly connected to the front end of the push-pull rod 521. The second handle rod extends horizontally and is positioned above the reagent container space 20A. The U-shaped handle 561 avoids the entrance and exit of the reagent container 30 at the front end of the reagent container space 20A.

[0324] The heat preservation unit 60 is configured to control the temperature of the reagent chamber 10. The heat preservation unit 60 includes a refrigerant circulation system 61. The refrigerant circulation system 61 includes a compressor 612, a first heat exchanger 613, a throttling device, and a second heat exchanger 615, which are sequentially connected via a refrigerant pipeline 611. To improve the heat exchange capacity of the first heat exchanger 613 and the second heat exchanger 615, a first fan 616 and a second fan 617 are also provided.

[0325] Figures 20 to 37 illustrate a reagent storage device 1 according to another embodiment of the present disclosure. Figures 20 to 37 illustrate that the reagent storage device 1 according to another embodiment of the present disclosure comprises a reagent compartment 10, a reagent cartridge storage unit 20, a reagent cartridge 30, a puncture unit 40, and a heat preservation unit 60, each of which employs the same structure as the embodiment shown in Figures 1 to 19. The composition, structure, and functions of these components can all refer to the embodiment shown in Figures 1 to 19. The following describes only the differences between the embodiments shown in Figures 20 and 37 and the embodiment shown in Figures 1 to 19.

[0326] As shown in Figures 20 to 37, the reagent storage device 1 of this embodiment does not include a base plate. In addition, the structure of the puncture drive unit 50 is different from the puncture drive unit 50 of the reagent storage device 1 of the embodiment shown in Figures 1 to 19, and a detection unit 80 is also provided.

[0327] In this embodiment, each puncture drive unit 50 includes a switching portion 51 , a linkage portion 52 , an actuating portion 56 , a supporting portion 57 and a movable connecting portion 58 .

[0328] In this embodiment, each puncture drive unit 50 includes two switching sections 51 corresponding to the two puncture units 40. Each switching section 51 is drivingly connected to or drivingly cooperates with the corresponding puncture unit 40 and is configured to drive the puncture unit 40 to switch between a first puncture operating state and a second puncture operating state. The two switching sections 51 are arranged in a linkage manner via a linkage section 52 to simultaneously drive the two puncture units 40 corresponding to the same reagent cartridge storage space 20A, so that the two puncture units 40 synchronously switch from the first puncture operating state to the second puncture operating state, or from the second puncture operating state to the first puncture operating state.

[0329] In this embodiment, multiple sample needles 41 of each puncture unit 42 are installed on the sample needle mounting portion 42, and the switching portion 51 is drivingly connected or drivingly coordinated with the sample needle mounting portion 42 of the puncture unit 40 to drive the multiple sample needles 41 to move synchronously.

[0330] The switching unit 51 includes a sample needle driving mechanism 511 and a sample needle resetting mechanism 512. The sample needle driving mechanism 511 applies a force to the puncture unit 40 to switch it from the first puncture operating state to the second puncture operating state. The sample needle resetting mechanism 512 applies a force to the puncture unit 40 to switch it from the second puncture operating state to the first puncture operating state.

[0331] The sample needle drive mechanism 511 includes a first movable portion 5111 and a second movable portion 5112. The first movable portion 5111 has a first drive operating position and a second drive operating position. The second movable portion 5112 is drivingly connected or drivingly engaged with the first movable portion 5111 and the puncture unit 40. When the first movable portion 5111 is in its first drive operating position, the puncture unit 40 is in its first puncture operating state. When the first movable portion 5111 is in its second drive operating position, the puncture unit 40 is in its second puncture operating state.

[0332] As shown in Figures 23-30 and Figures 32-37, the first movable part 5111 includes a first rotating part 51112, which is rotatable relative to the warehouse body 11; the second movable part 5112 includes a second rotating part 51122, which is rotatable relative to the warehouse body 11 and is drive-connected or drive-coordinated with the first rotating part 51112. The second rotating part 51122 drives the puncture unit 40 to switch between the first puncture working state and the second puncture working state.

[0333] In this embodiment, the first rotating member 51112 is a rotating shaft; the second rotating member 51122 includes a cam mounted on the rotating shaft, which presses against the puncture unit 40. The cam is directly fixed to the rotating shaft. In this embodiment, the rotating shaft and the cam thereon are both located outside the corresponding sample needle mounting portion 42 of the puncture unit 40. By changing the rotation angle of the cam relative to the sample needle mounting portion 42 as the rotating shaft and cam rotate, the cam drives the sample needle mounting portion 42 toward or away from the reagent cartridge receiving space 20A, thereby switching the puncture unit 40 between a first puncture operating state and a second puncture operating state. The first movable portion 5111, i.e., the first driven operating position of the rotating shaft, corresponds to a position where the major axis of the cam abuts the sample needle mounting portion 42. The second driven operating position of the first movable portion 5111, i.e., the rotating shaft, corresponds to a position where the minor axis of the cam abuts the sample needle mounting portion 42.

[0334] In the embodiment shown in Figures 20 to 37, the sample needle driving mechanism 511 is configured to apply a force to the puncture unit 40 to switch it from the second puncture operating state to the first puncture operating state. The sample needle resetting mechanism 512 is configured to apply a force to the puncture unit 40 to switch it from the first puncture operating state to the second puncture operating state.

[0335] Each loading needle reset mechanism 512 includes four springs 5121, located at the four corners of the reagent cartridge storage unit 20. The two ends of each spring 5121 are connected to the loading needle mounting portion 42 and the crossbeam 571. Each spring 5121 is a tension spring, thus applying a force to the loading needle mounting portion 42 away from the reagent cartridge storage unit 20. In other words, the loading needle reset mechanism 512 is configured to apply a force to the puncture unit 40, causing it to switch from the first puncture operating state to the second puncture operating state.

[0336] As shown in Figures 23-24, 26-29, and 32-37, the linkage portion 52 is drivingly connected or drivingly coordinated with the two switching portions 51 to synchronize the movement of the puncture units 40 corresponding to at least the two switching portions 51. The linkage portion 52 includes a first rotating member 51112 connected to the two switching portions 51, i.e., a belt transmission mechanism 522 between the rotating shafts.

[0337] The belt transmission mechanism 522 includes a pulley 5221 and a pulley 5222 connected to two rotating shafts, respectively, and a conveyor belt 5223 mounted on the pulleys 5221 and 5222. The belt transmission mechanism 522 causes the two rotating shafts of the same puncture drive unit 50 to rotate synchronously in opposite directions, thereby driving the two cams to rotate synchronously in opposite directions, and in turn driving the sample needle mounting portion 42 to move synchronously in opposite directions, thereby synchronously switching the upper and lower puncture units 40 from the first puncture operating state to the second puncture operating state, or vice versa.

[0338] In the embodiment shown in Figures 20 to 37, the actuator 56 includes a rotating handle 562, which is fixedly connected to the rotating shaft. The rotating handle 562 is disposed on the side of the chamber body 11 where the chamber door 12 is disposed, i.e., the front side. Rotating the rotating handle 562 drives the rotating shaft to rotate, thereby driving the cam to rotate, switching the puncture unit 40 between the first puncture operating state and the second puncture operating state.

[0339] The support portion 57 is used to mount the switching portion 51 and the linkage portion 52. The support portion 57 includes a crossbeam 571 disposed on the front and rear sides of each of the upper and lower sides of the chamber body 11, a connecting beam 572 connected to the front and rear crossbeams 571, a longitudinal beam 573 connected between the upper and lower rear crossbeams 571, and two bearings 574 located in the bearing holes at the upper and lower ends of the longitudinal beam 573. Each of the upper and lower rotating shafts passes through the crossbeams 571 on its front and rear sides and is rotatably supported on the two crossbeams 571. The ends of the rotating shafts respectively pass through the corresponding crossbeams 571. The rear end of the rotating shaft passes through the corresponding bearing 574 and is connected to the pulley 5221 or 5222. The front end of the rotating shaft is connected to the actuator 56. The crossbeam 571, the connecting beam 572, and the longitudinal beam 573 are all fixed to the reagent box storage unit 20.

[0340] The movable connection portion 58 is connected to the cam and the puncture unit 40, respectively, and is configured to transmit the movement of the cam to the puncture unit 40, so that the rotation of the cam drives the puncture unit 40. As shown in Figures 29-30, the movable connection portion 58 includes a movable element 581, a first pin 582, and a second pin 583. The first pin 582 is disposed on the end surface of the cam. The second pin 583 is disposed on the puncture unit 40 in parallel and spaced apart from the first pin 582. The movable element 581 has an arcuate groove 581A. The movable element 581 is mounted on the cam and the puncture unit 40 through the first pin 582 and the second pin 583 engaging with the arcuate groove 581A. The first pin 582 and the second pin 583 slide in the arcuate groove 581A.

[0341] In the embodiments shown in Figures 20 to 37, the components of the reagent storage device 1 located inside the reagent chamber 10, such as the reagent chamber storage unit 20, the puncture unit 40 and the puncture drive unit 50 are all installed on the bottom wall of the chamber body 11 of the reagent chamber 10.

[0342] The detection unit 80 includes, for example, a reagent kit detection unit 81 for detecting whether the reagent kit 30 is properly installed in the reagent kit accommodating space 20A, and / or a door detection unit 82 for detecting whether the door 12 is tightly closed. The reagent kit detection unit 81 and the door detection unit 82 may be, for example, electromagnetic sensors, photoelectric sensors, etc.

[0343] The above embodiments are not intended to limit the present disclosure. For example, although the embodiment shown in Figures 1 to 19 of the present disclosure does not include a detection unit 80, in a modified example of this embodiment, a detection unit 80 may also be provided. For another example, although the puncture drive unit 50 of the embodiment shown in Figures 20 to 37 does not include a limiting portion, a guide portion, and a positioning portion, in some modified examples of this embodiment, at least one of the limiting portion, the guide portion, and the positioning portion may still be provided.

[0344] Figure 38 shows a reagent operating system according to an embodiment of the present disclosure. As shown in Figure 38, the reagent operating system provided by the embodiment of the present disclosure includes the reagent storage device 1 of the aforementioned embodiment of the present disclosure. The reagent operating system further includes a reagent receiving portion 2, a cleaning liquid delivery portion 3, and a gas connection portion 4. The reagent receiving portion 2 is connected to the internal channel 41A of the sample injection needle 41 of the puncture unit 40 located below the reagent reagent storage space 20A. The gas connection portion 4 and the cleaning liquid delivery portion 3 are respectively connected to the internal channel 41A of the sample injection needle 41 of the puncture unit 40 located above the reagent reagent storage space 20A. The reagent receiving portion 2 is connected to the corresponding sample injection needle 41 via a connecting tube that passes through the chamber body 11 and is sealed therewith. The gas connection portion 4 and the cleaning liquid delivery portion 3 are connected to the corresponding sample injection needle 41 via a connecting tube that passes through the chamber body 11 and is sealed therewith.

[0345] The reagent operating system may include a controller. The controller is used to control the reagent operating system. The controller is for example coupled with the reagent receiving portion 2, the cleaning fluid delivery portion 3 and / or the gas communication portion 4. If the reagent storage device 1 includes a detection unit 80 and / or includes an actuator, the controller may also be coupled with the detection unit 80 and / or the actuator to receive the detection signal of the detection unit 80 and / or send a control instruction to the actuator. The controller may be implemented as a general purpose processor for performing the function described in the present disclosure, a programmable logic controller (PLC), a digital signal processor (DSP), an application specific integrated circuit (ASIC), a field programmable gate array (FPGA) or other programmable logic devices, discrete gates or transistor logic devices, discrete hardware components or any suitable combination thereof.

[0346] The operating procedures of the reagent operating system are described as follows:

[0347] Open the compartment door 12, pull the handle 561 to the frontmost position or rotate the rotary handle 562 to position the puncture unit 40 in the second puncture working position. If there is a used reagent cartridge 30 inside, remove it and place the reagent cartridge 30 into the reagent cartridge storage space 20A, ensuring it is properly installed. Push the handle 561 or rotate the rotary handle to switch the puncture unit 40 from the second puncture working position to the first puncture working position, forcing the sample needle mounting portions 42 and sample needles 41 of the upper and lower puncture units 40 to simultaneously move toward the reagent cartridge storage space 20A. Each reagent needle 41 penetrates the corresponding weak portion 301 of the reagent cartridge 30, connecting the sample needle pinhole 41B with the corresponding reagent storage space 30A. Close the compartment door 12.

[0348] After the reagent cartridge 30 is installed and the compartment door 12 is fully closed, the test process is initiated, and the reagent operating system performs the relevant tests, including controlling the connection and disconnection between the reagent receiving portion 2 and / or the gas connection portion 4 and the reagent storage space 30A. If a controller is provided, the relevant tests can be completed through the controller. If a monitoring unit is communicatively connected to the controller, the position of the reagent cartridge 30 and the compartment door 12 can be monitored by the monitoring unit and the controller.

[0349] After the test is completed, the cleaning liquid delivery unit 3 is controlled to supply cleaning liquid to the corresponding reagent storage space 30A. The corresponding end of the sample injection needle 41 at the bottom of the reagent storage space 30A is immersed in the cleaning liquid. The cleaning liquid can be emptied by an external device. By repeatedly using different cleaning solutions, the sample injection needle 41 can be cleaned to the desired level of cleanliness.

[0350] Open the compartment door 12, pull the handle 561 to the front or rotate the rotary handle 562 to switch the puncture unit 40 to the second puncture working state, disconnect the sample needle 41 from the corresponding reagent storage space 30A, and then pull out the reagent kit 30 to complete the test cleaning process.

[0351] In this reagent operating system, the reagent receiving part 2 can introduce the reagent in the reagent kit 30 into the reagent receiving part 2 to realize the reagent transfer; the gas connecting part 4 can introduce gas into the reagent storage space 30A of the reagent kit 30 during the reagent transfer, thereby facilitating the control of the pressure of the reagent storage space 30A and the speed of the reagent outflow; the cleaning liquid delivery part 3 can introduce the cleaning liquid into the reagent kit 30 after the reagent transfer to clean the sample injection needle 41 that has been in contact with the reagent, thereby realizing the cleaning of the sample injection needle 41.

[0352] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit the present invention. Although the present invention has been described in detail with reference to preferred embodiments, ordinary technicians in the field should understand that the specific implementation methods of the present invention can still be modified or some technical features can be replaced by equivalents without departing from the spirit of the technical solutions of the present invention. They should all be included in the scope of the technical solutions claimed for protection by the present invention.

Claims

1. A reagent storage device (1), comprising: A reagent chamber (10) comprising a chamber body (11) and a chamber door (12) for closing the chamber body (11); A reagent box storage unit (20) is disposed in the chamber (11) and includes a reagent box accommodating space (20A), wherein the reagent box accommodating space (20A) is configured to accommodate a reagent box (30) having a reagent storage space (30A); and The puncture unit (40) comprises a sample loading needle (41) arranged in the chamber (11), the sample loading needle (41) having an internal channel (41A) and a puncture end (41C), the puncture end (41C) being provided with a sample loading needle pinhole (41B) communicating with the internal channel (41A), the puncture unit (40) being movably arranged relative to the reagent box storage unit (20) and having a first puncture working state and a second puncture working state, the puncture unit (40) being configured as follows: when the reagent box (30) is placed in the reagent box accommodating space (20A), in the first puncture working state, the sample loading needle pinhole (41B) is communicated with the reagent storage space (30A) of the reagent box (30), and in the second puncture working state, the sample loading needle pinhole (41B) is disconnected from the reagent storage space (30A) of the reagent box (30).

2. The reagent storage device (1) according to claim 1, wherein: The reagent storage device (1) includes two or more puncture units (40) arranged corresponding to the same reagent kit accommodating space (20A).

3. The reagent storage device (1) according to claim 2, wherein: Among the two or more puncture units (40) provided corresponding to the same reagent box accommodating space (20A), the puncture end (41C) of the sample injection needle (41) of at least one puncture unit (40) is located outside or below the bottom of the corresponding reagent box accommodating space (20A); and / or Among the two or more puncture units (40) arranged corresponding to the same reagent kit accommodating space (20A), the puncture end (41C) of the sample addition needle (41) of at least one of the puncture units (40) is located outside or above the top of the corresponding reagent kit accommodating space (20A).

4. The reagent storage device (1) according to any one of claims 1 to 3, wherein: The reagent kit storage unit (20) includes a reagent kit protection portion (21) disposed between the sample injection needle (41) and the reagent kit accommodating space (20A), and the reagent kit protection portion (21) has a puncture end avoidance opening (21A) for avoiding the puncture end (41C) of the sample injection needle (41).

5. The reagent storage device (1) according to any one of claims 1 to 4, wherein: At least part of the sample injection needle (41) of the puncture unit (40) comprises: a sample adding needle tube (411), wherein the internal channel (41A) is located in the sample adding needle tube (411); and The sampling needle tip (412) is located at the puncture end (41C) of the sampling needle (41) and is connected to one end of the sampling needle tube (411). The sampling needle tip (412) is a cone whose cross-section gradually decreases from the sampling needle tube (411) to the side away from the sampling needle tube (411); wherein the sampling needle hole (41B) is located on the side wall of the sampling needle tube (411) close to the sampling needle tip (412).

6. The reagent storage device (1) according to any one of claims 1 to 5, wherein: The sample addition needle (41) comprises a sample addition needle tube (411) and a sample addition needle tip (412) located at the puncture end (41C) and connected to the sample addition needle tube (411), wherein: The sample adding needle tube (411) has at least one sample adding needle curved tube section (4112); and / or The sample addition needle tube (411) has at least one flexible tube section; and / or The sample adding needle tube (411) has at least one telescopic tube section.

7. The reagent storage device (1) according to claim 6, wherein: The sample adding needle tube (411) comprises: A first sample addition needle straight tube section (4111) extends along the wall surface of the chamber body (11); and The second sample loading needle straight tube section (4113) extends from one side of the wall surface of the storage body (11) toward the reagent kit accommodating space (20A), one end of the second sample loading needle straight tube section (4113) is connected to one end of the first sample loading needle straight tube section (4111) via a sample loading needle curved tube section (4112), and the sample loading needle tip (412) is connected to the other end of the second sample loading needle straight tube section (4113).

8. The reagent storage device (1) according to any one of claims 1 to 7, wherein: The puncture unit (40) further comprises a sample adding needle mounting portion (42), and the sample adding needle (41) is fixed on the sample adding needle mounting portion (42).

9. The reagent storage device (1) according to any one of claims 1 to 8, wherein: The reagent storage device (1) further includes a puncture drive unit (50), including a switching portion (51) that is drive-connected or drive-coordinated with the puncture unit (40), and the switching portion (51) is configured to drive the puncture unit (40) to switch between the first puncture working state and the second puncture working state.

10. The reagent storage device (1) according to claim 9, wherein: The reagent storage device (1) includes two or more puncture units (40), and the puncture drive unit (50) includes two or more switching parts (51) corresponding to the puncture units (40), wherein at least two of the switching parts (51) are arranged in a linked manner.

11. The reagent storage device (1) according to claim 10, wherein: The reagent storage device (1) includes two or more puncture units (40) arranged corresponding to the same reagent kit accommodating space (20A), and the puncture drive unit (50) includes two or more switching parts (51) corresponding to the two or more puncture units (40) arranged corresponding to the same reagent kit accommodating space (20A), and the two or more switching parts (51) are arranged in a linked manner so that the corresponding two or more puncture units (40) are synchronously switched from the first puncture working state to the second puncture working state or from the second puncture working state to the first puncture working state.

12. The reagent storage device (1) according to any one of claims 9 to 11, wherein: The puncture unit (40) comprises a sample needle mounting portion (42) and a plurality of sample needles (41), wherein the plurality of sample needles (41) are mounted on the sample needle mounting portion (42), and the switching portion (51) is drivingly connected or drivingly matched with the sample needle mounting portion (42) of the puncture unit (40) to drive the plurality of sample needles (41) to move synchronously.

13. The reagent storage device (1) according to any one of claims 9 to 12, wherein: The switching portion (51) includes a sample needle driving mechanism (511), and the sample needle driving mechanism (511) is configured to apply a force to the puncture unit (40) to switch it from the first puncture working state to the second puncture working state and / or apply a force to switch it from the second puncture working state to the first puncture working state.

14. The reagent storage device (1) according to claim 13, wherein: The sample adding needle driving mechanism (511) comprises: A first movable portion (5111) having a first driving working position and a second driving working position; The second movable part (5112) is driven to be connected or driven to cooperate with the first movable part (5111) and the puncture unit (40) to transmit the action of the first movable part (5111) to the puncture unit (40), wherein, when the first movable part (5111) is in the first driving working position, the puncture unit (40) is in one of the first puncture working state and the second puncture working state, and when the first movable part (5111) is in the second driving working position, the puncture unit (40) is in the other of the first puncture working state and the second puncture working state.

15. The reagent storage device (1) according to claim 14, wherein: The puncture drive unit (50) comprises a linkage part (52), and the linkage part (52) is drivingly connected or drivingly matched with at least two of the switching parts (51) so that the puncture units (40) corresponding to the at least two switching parts (51) move synchronously.

16. The reagent storage device (1) according to claim 14 or 15, wherein: The puncture drive unit (50) comprises: a limiting portion (53), wherein the limiting portion (53) is configured to limit the range of motion of the first movable portion (5111) and / or the second movable portion (5112); and / or A guide portion (54), wherein the guide portion (54) is configured to guide the movement of the first movable portion (5111) and / or the second movable portion (5112).

17. The reagent storage device (1) according to claim 16, wherein: The limiting portion (53) is configured to limit the range of motion of the linkage portion (52) to limit the range of motion of the first movable portion (5111) and / or the second movable portion (5112); and / or The guide portion (54) is configured to guide the movement of the linkage portion (52) so as to guide the movement of the first movable portion (5111) and / or the second movable portion (5112).

18. The reagent storage device (1) according to claim 16 or 17, wherein: The limiting portion (53) comprises a limiting groove (53A) and a limiting surface (53B), the limiting surface (53B) is movably located in the limiting groove (53A) and is in abutment with the limiting groove (53A), one of the limiting groove (53A) and the limiting surface (53B) is fixed relative to one of the first movable portion (5111) and the second movable portion (5112), and the other is fixed relative to the other of the first movable portion (5111) and the second movable portion (5112); and / or The guide portion (54) includes one or more guide structures, at least one guide structure includes a guide groove (54A) and a guide surface (54B), the guide surface (54B) is slidably matched with the guide groove (54A), one of the guide groove (54A) and the guide surface (54B) is fixed relative to the warehouse body (11), and the other is fixed relative to the first movable portion (5111) or the second movable portion (5112).

19. The reagent storage device (1) according to any one of claims 14 to 18, wherein: The puncture drive unit (50) further includes a positioning portion (55), wherein the positioning portion (55) has a positioning state for maintaining the puncture unit (40) in the first puncture working state and / or the second puncture working state and an avoidance state for preventing interference with the switching of the working position of the puncture unit (40), and the positioning portion (55) is movably arranged relative to the chamber body (11) to switch between the avoidance state and the positioning state.

20. The reagent storage device (1) according to claim 19, wherein: The positioning portion (55) is driven and matched with the reagent box (30) to switch between the avoidance state and the positioning state under the drive of the reagent box (30).

21. The reagent storage device (1) according to claim 20, wherein: The positioning portion (55) includes a slider (551) and a slider reset mechanism (552). The slider (551) is movably installed in the warehouse body (11) relative to the warehouse body (11) and includes a positioning surface (5511D). The slider (551) is driven to cooperate with the reagent box (30). In the avoidance state of the positioning portion (55), the slider (551) is in an avoidance position where the positioning surface (5511D) is separated from the second movable portion (5112), and the slider reset mechanism (552) is in a force storage state. In the positioning state of the positioning portion (55), the slider (551) is in a positioning position where the positioning surface (5511D) abuts against the second movable portion (5112), and the slider reset mechanism (552) is in a force release state.

22. The reagent storage device (1) according to any one of claims 14 to 21, wherein: The first movable portion (5111) comprises a first translation component (51111), the first translation component (51111) being reciprocally movable relative to the bin body (11) along a first direction (X), the first translation component (51111) being provided with a driving surface (51111A), the driving surface (51111A) being inclined along the first direction (X) toward a second direction (Z) perpendicular to the first direction (X); The second movable portion (5112) includes a second translation component (51121), which is fixedly arranged relative to the sample injection needle (41) and can be reciprocated relative to the chamber body (11) along the second direction (Z). The second translation component (51121) is provided with a mating surface (51121A) corresponding to the driving surface (51111A), and the mating surface (51121A) is inclined along the first direction (X) toward the second direction (Z). By changing the position of the first translation component (51111) in the first direction (X), the mating position of the driving surface (51111A) and the mating surface (51121A) is changed to change the position of the second translation component (51121) along the second direction (Z).

23. The reagent storage device (1) according to claim 22, wherein: The puncture drive unit (50) includes a linkage part (52), and the linkage part (52) is drivingly connected to at least two of the switching parts (51) or drivingly cooperates with the at least two switching parts (51) to make the puncture units (40) corresponding to the at least two switching parts (51) move synchronously, wherein: The linkage portion (52) includes a push-pull rod (521) extending along the first direction (X); The first translation component (51111) is fixed on the push-pull rod (521), and the driving surface (51111A) is arranged on a side of the push-pull rod (521) close to the second translation component (51121); The second translation component (51121) includes a pressure plate, which is arranged along the second direction (Z), and the mating surface (51121A) is provided at an end of the pressure plate close to the first translation component (51111).

24. The reagent storage device (1) according to claim 23, wherein The puncture drive unit (50) includes a limiting portion (53), the limiting portion (53) is configured to limit the range of motion of the linkage portion (52) so as to limit the range of motion of the first movable portion (5111), the limiting portion (53) includes a limiting groove (53A) and a limiting surface (53B), the limiting surface (53B) is movably located in the limiting groove (53A) and is in abutment with the limiting groove (53A), one of the limiting groove (53A) and the limiting surface (53B) is provided on the second movable portion (5112), and the other is provided on the push-pull rod (521); and / or The puncture drive unit (50) includes a guide portion (54), which is configured to guide the movement of the linkage portion (52) to guide the movement of the first movable portion (5111), and the guide portion (54) includes one or more guide structures, at least one of which includes a guide groove (54A) and a guide surface (54B), one of the guide groove (54A) and the guide surface (54B) is fixed relative to the magazine body (11), and the other is arranged on the push-pull rod (521).

25. The reagent storage device (1) according to any one of claims 14 to 20, wherein: The first movable portion (5111) includes a first rotating component (51112), and the first rotating component (51112) is rotatably arranged relative to the warehouse body (11); The second movable part (5112) includes a second rotating component (51122), which is rotatably arranged relative to the warehouse body (11) and is drivingly connected or drivingly matched with the first rotating component (51112). The second rotating component (51122) drives the puncture unit (40) to switch between the first puncture working state and the second puncture working state.

26. The reagent storage device (1) according to claim 25, wherein The first rotating component (51112) is a rotating shaft; The second rotating component (51122) includes a cam arranged on the rotating shaft, and the cam is pressed and fitted with the puncture unit (40).

27. The reagent storage device (1) according to claim 26, wherein: The puncture drive unit (50) further includes a movable connection portion (58), which is respectively connected to the cam and the puncture unit (40), and is configured to transmit the movement of the cam to the puncture unit (40) so that the rotation of the cam drives the puncture unit (40) to move.

28. The reagent storage device (1) according to claim 27, wherein The movable connection part (58) comprises: a first pin (582) disposed on an end surface of the cam; a second pin (583) provided on the puncture unit (40) in parallel and spaced apart from the first pin (582); The movable element (581) has an arc-shaped groove (581A). The movable element (581) is installed on the cam and the puncture unit (40) through the first pin (582) and the second pin (583) cooperating with the arc-shaped groove (581A). The first pin (582) and the second pin (583) are slidably engaged with the arc-shaped groove (581A).

29. The reagent storage device (1) according to any one of claims 25 to 28, wherein: The puncture drive unit (50) includes a linkage portion (52), and the linkage portion (52) is drivingly connected or drivingly matched with at least two of the switching portions (51) so that the puncture units (40) corresponding to the at least two switching portions (51) move synchronously; The linkage part (52) includes at least one of a belt transmission mechanism (522), a chain transmission mechanism, a gear transmission mechanism, a gear and rack transmission mechanism, or a connecting rod mechanism connected between the first rotating parts (51112) of the at least two switching parts (51).

30. The reagent storage device (1) according to any one of claims 14 to 29, wherein: The puncture drive unit (50) further includes an actuating portion (56), the actuating portion (56) being drivingly connected or drivingly matched with the first movable portion (5111); the actuating portion (56) includes: A handle (561) or a rotating handle (562) is drivingly connected to or drivingly matched with the first movable part (5111), and the handle (561) or the rotating handle (562) is provided on a side of the warehouse body (11) where the warehouse door (12) is provided; or An actuator is drivingly connected to or drivingly engaged with the first movable part (5111).

31. The reagent storage device (1) according to any one of claims 13 to 30, wherein: in, The switching part (51) includes a sample needle reset mechanism (512), wherein: One of the sample needle driving mechanism (511) and the sample needle resetting mechanism (512) is configured to apply a force to the puncture unit (40) to switch the puncture unit from the first puncture working state to the second puncture working state; The other of the sample adding needle driving mechanism (511) and the sample adding needle resetting mechanism (512) is configured to apply a force to the puncture unit (40) to switch it from the second puncture working state to the first puncture working state.

32. The reagent storage device (1) according to claim 31, wherein The sample injection needle reset mechanism (512) includes at least one spring (5121); wherein, The spring (5121) is located and / or connected between the puncture unit (40) and the reagent kit storage unit (20); or The spring (5121) is located and / or connected between the puncture unit (40) and the chamber body (11).

33. The reagent storage device (1) according to any one of claims 1 to 32, wherein: The reagent storage device (1) includes a plurality of reagent kit storage units (20), and / or the reagent kit storage unit (20) includes a plurality of reagent kit accommodating spaces (20A).

34. The reagent storage device (1) according to any one of claims 1 to 33, wherein: The reagent storage device (1) further includes a heat preservation unit (60), and the heat preservation unit (60) is configured to maintain the temperature of the reagent chamber (10).

35. The reagent storage device (1) according to claim 34, wherein The heat preservation unit (60) includes a refrigerant circulation system (61), and the refrigerant circulation system (61) is configured to regulate the temperature inside the reagent chamber (10).

36. The reagent storage device (1) according to any one of claims 1 to 35, wherein: The reagent storage device (1) includes a reagent kit (30), the reagent kit (30) includes a reagent storage space (30A), and the reagent kit accommodating space (20A) of the reagent storage device (1) is used to place the reagent kit (30); In the first puncture working state of the puncture unit (40), the sample needle hole (41B) is connected to the reagent storage space (30A) of the reagent kit (30) placed in the reagent kit accommodating space (20A), and in the second puncture working state of the puncture unit (40), the sample needle hole (41B) is disconnected from the reagent storage space (30A) of the reagent kit (30) placed in the reagent kit accommodating space (20A).

37. The reagent storage device (1) according to claim 36, wherein The reagent box (30) has a weak portion (301) corresponding to the puncture end (41C) of the sample addition needle (41). In the first puncture working state of the puncture unit (40), the puncture end (41C) of the sample addition needle (41) enters the reagent storage space (30A) by puncturing the weak portion (301), thereby achieving communication between the sample addition needle hole (41B) of the sample addition needle (41) and the reagent storage space (30A) of the reagent box (30).

38. The reagent storage device (1) according to any one of claims 1 to 37, wherein: It also includes a bottom plate (70), which is located in the reagent compartment (10) and installed on the bottom wall of the compartment body (11), and the reagent kit storage unit (20) and / or the puncture unit (40) are installed on the bottom plate (70).

39. A reagent operating system, comprising the reagent storage device (1) according to any one of claims 1 to 38; wherein the reagent operating system further comprises: The reagent receiving portion (2) is in communication with the internal channel (41A) of the sample injection needle (41) of at least one of the puncture units (40); and / or The cleaning liquid delivery portion (3) is in communication with the internal channel (41A) of the sample injection needle (41) of at least one of the puncture units (40); and / or The gas communication portion (4) is in communication with an internal channel (41A) of the sample addition needle (41) of at least one of the puncture units (40).

40. The reagent operating system according to claim 39, wherein The reagent operating system comprises the reagent receiving portion (2) and the cleaning liquid delivery portion (3), wherein the reagent receiving portion (2) and the cleaning liquid delivery portion (3) are respectively in communication with the internal channels (41A) of the sample injection needles (41) of different puncture units (40); and / or The reagent operating system includes the cleaning liquid delivery part (3) and the gas communication part (4), and the cleaning liquid delivery part (3) and the gas communication part (4) are in a communication state with the internal channel (41A) of the sample injection needle (41) of the same puncture unit (40) at different time periods.

41. The reagent operating system according to claim 39 or 40, wherein The reagent operating system comprises the reagent receiving part (2) and the cleaning liquid delivery part (3), wherein: The puncture end (41C) of the sample adding needle (41) of the puncture unit (40) in communication with the reagent receiving portion (2) is located outside or below the bottom of the corresponding reagent cartridge accommodating space (20A); The puncture end (41C) of the sample addition needle (41) of the puncture unit (40) in communication with the cleaning liquid delivery portion (3) is located outside or above the top of the corresponding reagent kit accommodating space (20A).

42. The reagent operating system according to any one of claims 39 to 41, wherein The reagent receiving portion (2) is connected to the sample injection needle (41) of at least one of the puncture units (40) via a connecting tube having a flexible tube section or a telescopic tube section; and / or The cleaning liquid delivery portion (3) is connected to the sample addition needle (41) of at least one of the puncture units (40) via a connecting tube having a flexible tube section or a telescopic tube section; and / or The gas communication portion (4) is connected to the sample addition needle (41) of at least one of the puncture units (40) via a connecting tube having a flexible tube section or a telescopic tube section.

43. The reagent operating system according to any one of claims 39 to 42, wherein: The reagent receiving portion (2) is connected to the sample injection needle (41) of at least one of the puncture units (40) via a connecting tube that passes through the chamber (11) and is sealed with the chamber (11); and / or The cleaning liquid delivery portion (3) is connected to the sample injection needle (41) of at least one of the puncture units (40) via a connecting tube that passes through the chamber (11) and is sealed with the chamber (11); and / or The gas communication portion (4) is connected to the sample addition needle (41) of at least one of the puncture units (40) via a connecting tube that passes through the chamber body (11) and is sealed with the chamber body (11).

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