Bamboo vinegar powder foot patch and preparation method thereof

Abstract

The invention discloses a bamboo vinegar powder foot patch and a preparation method thereof. The bamboo vinegar powder foot patch is prepared from the following raw materials in percentage by mass: 50 to 65 percent of bamboo vinegar powder, 15 to 30 percent of plant extract and 15 to 25 percent of auxiliary components, the plant extract is one or more of a lavender extract, a folium artemisiae argyi extract, a platycodon root extract, a liquorice extract and a fructus evodiae extract. According to the bamboo vinegar powder foot patch with the structure and the preparation method of the bamboo vinegar powder foot patch, the prepared bamboo vinegar powder foot patch can stimulate plantar meridians and collaterals, blood circulation is promoted, fatigue and pain caused by unsmooth blood circulation are relieved, plant ingredients such as the lavender extract and the folium artemisiae argyi extract are rich in natural aromatic substances, and the bamboo vinegar powder foot patch is free of toxic and side effects. The traditional Chinese medicine composition has the effects of tranquilizing and allaying excitement and relieving nervous mood, and also has a good improvement effect on oral ulcer patients and internal heat patients.

Description

Technical Field

[0001] The invention relates to the technical field of foot patches, in particular to a bamboo vinegar powder foot patch and a preparation method thereof. Background Art

[0002] With the acceleration of modern life and the enhancement of people's health awareness, the market demand for health care products is growing. Foot patches are a convenient and effective external health care product, which are widely favored by consumers because they can promote blood circulation, expel toxins from the body, and relieve fatigue through the reflexology of the soles of the feet. Bamboo vinegar powder, as one of the key ingredients in foot patches, plays an important role in the production of foot patches because of its natural, safe and multi-effect characteristics.

[0003] Bamboo vinegar powder is a natural precious essence obtained by high-temperature distillation of bamboo. It is rich in more than 200 natural organic ingredients and minerals. Its main ingredients include acetic acid, phenolic compounds, alcohols and aldehydes, etc. It has multiple functions such as anti-inflammatory and antibacterial, insect repellent and fresh-keeping, deodorizing and beauty. In foot patches, bamboo vinegar powder can not only promote the transdermal absorption of drug ingredients, but also help eliminate dampness and toxins in the body and improve blood circulation, thereby achieving the purpose of health care.

[0004] However, there are many foot patch products on the market, many of which contain bamboo vinegar powder as a key ingredient. However, these products differ in the formulation and content of bamboo vinegar powder, resulting in uneven product effects. Some products have a low content of bamboo vinegar powder and cannot fully exert its efficacy; while others may cause skin discomfort due to excessive content. In addition, there is also a lack of unified standards for the determination of bamboo vinegar powder content in the prior art, which brings difficulties to product quality control.

[0005] At present, the formulation of bamboo vinegar powder in foot patch products mostly relies on experience and lacks scientific and systematic research, which makes it difficult to predict and control the product effect. In-depth analysis found that the main functions of bamboo vinegar powder in foot patches include detoxification, dehumidification, improving blood circulation, relieving fatigue, improving skin problems, and assisting in regulating the stomach and improving immunity. Unfortunately, these effects lack objective and simple evaluation methods. At the same time, the determination methods of bamboo vinegar powder content are diverse but lack unified standards, making it difficult to compare and control the quality of different products. Some products may cause adverse reactions such as skin irritation and allergies due to improper bamboo vinegar powder content or unreasonable combination with other ingredients, affecting consumer health. Therefore, there is an urgent need for a bamboo vinegar powder content determination method and a foot patch with bamboo vinegar powder as raw material and better health care effects. Summary of the invention

[0006] The purpose of the present invention is to provide a bamboo vinegar powder foot patch and a preparation method thereof, so as to solve the problems that the content of bamboo vinegar powder is difficult to determine, the formula of bamboo vinegar powder foot patch is unreasonable, and the health care effect is poor.

[0007] To achieve the above object, the first aspect of the present invention provides a bamboo vinegar powder foot patch, which comprises the following raw materials in terms of mass percentage:

[0008] Bamboo vinegar powder 50-65%

[0009] Plant extracts 15-30%

[0010] Auxiliary ingredients 15-25%;

[0011] The plant extract is one or more of lavender extract, wormwood leaf extract, platycodon root extract, licorice extract and evodia rutaecarpa extract.

[0012] Preferably, the preparation process of the plant extract is:

[0013] (1) subjecting one or more Chinese medicinal raw materials selected from lavender, wormwood leaf, platycodon root, liquorice or evodia rutaecarpa to quality inspection, crushing the qualified raw materials and passing through a 50-mesh sieve;

[0014] (2) First extraction

[0015] Add the crushed Chinese medicine raw materials into the extraction tank;

[0016] Take deionized water and add it to the extraction tank. After soaking for 10 to 50 minutes, heat it to 85 to 100°C and keep it warm for 0.5 to 2 hours.

[0017] Cool down to 40-50℃, filter out the drug residue, and collect the first extract;

[0018] (3) Second extraction

[0019] Add deionized water to the drug residue, soak for 10 to 50 minutes, raise the temperature to 85 to 100° C., and keep warm for 0.5 to 2 hours;

[0020] Cool down to 40-50°C, filter out the drug residue, collect the second extract, and combine it with the first extract to obtain the total extract;

[0021] (4) Concentration and drying

[0022] The combined total extract is concentrated to remove excess water, and dried in a microwave dryer to form an extract;

[0023] (5) Crushing and screening

[0024] The dried extract is crushed and passed through an 80-mesh sieve to obtain Chinese medicine extract powder, i.e., plant extract.

[0025] Preferably, the deionized water added in step (2) is 5 to 15 times the weight of the Chinese medicinal raw material.

[0026] Preferably, the deionized water added in step (3) is 5 to 10 times the weight of the Chinese medicinal raw material.

[0027] Preferably, the auxiliary component is one or more of tourmaline, chitin, nano negative ion powder, Vc, and VE.

[0028] The second aspect of the present invention provides a method for preparing a bamboo vinegar powder foot patch, comprising the following steps:

[0029] (1) Mixing: Add bamboo vinegar powder, plant extract and auxiliary ingredients into a mixer according to a certain proportion, and stir until the mixture is uniform;

[0030] (2) Sieving: Pass the mixed powder through an 80-mesh sieve;

[0031] (3) Bagging: The sieved powder is placed in a medicine bag with one side made of paper and the other side made of non-woven fabric;

[0032] (4) Sealing: Use a heat sealer to seal the bag mouth to obtain a foot patch bag;

[0033] (5) Packaging: The foot patch medicine bag and the additional patch are respectively placed in a sealed bag or a packaging box to obtain the bamboo vinegar powder foot patch.

[0034] Therefore, the present invention adopts a bamboo vinegar powder foot patch and a preparation method thereof of the above structure, which has the following characteristics:

[0035] Beneficial effects:

[0036] (1) The foot patch of the present invention uses bamboo vinegar powder and a variety of natural plant extracts as main ingredients, has no chemical additives, is safe and harmless, and is suitable for long-term use. The present invention mixes the raw materials according to a specific ratio to ensure that the efficacy of each ingredient is fully exerted, while avoiding the interaction between the ingredients that affects the effect.

[0037] (2) The bamboo vinegar powder of the present invention has a warming effect. By applying it to the sole of the foot, it can stimulate the meridians of the sole of the foot, promote blood circulation, and help relieve fatigue and pain caused by poor blood circulation. Plant ingredients such as lavender extract and wormwood extract are rich in natural aromatic substances, which have the effects of calming the mind and relieving tension, and can help users relax their body and mind and relieve daily fatigue. Bamboo vinegar powder and some plant extracts (such as Evodia rutaecarpa) have the effects of removing dampness and detoxification. Applying them to the acupuncture points on the sole of the foot can promote the discharge of moisture and toxins in the body, and help improve physical fitness.

[0038] (3) The foot patch of the present invention has the effects of clearing away heat and reducing internal heat, promoting metabolism and soothing emotions for patients suffering from internal heat. The plant extracts in the formula, such as licorice, have the effect of clearing away heat and detoxifying. Although the direct effect of applying the patch directly to the sole of the foot on the symptoms of internal heat may be limited, it may help relieve the internal heat discomfort caused by internal heat by regulating the overall state of the body; bamboo vinegar powder and other plant ingredients can stimulate the meridians of the sole of the foot, promote blood circulation and metabolism, and help the body discharge excess heat and toxins, thereby alleviating the symptoms of internal heat; the aroma of plant extracts such as lavender helps relieve tension and relieve the irritability and anxiety that may be caused by internal heat.

[0039] (4) The foot patch of the present invention has the effects of improving immunity, promoting blood circulation and assisting conditioning for patients with oral ulcers. Among them, plant extracts such as platycodon root and licorice are rich in multiple active ingredients and have the function of enhancing immunity. Improving the body's immunity helps the body resist viral and bacterial invasion and reduce the occurrence of oral diseases such as oral ulcers; bamboo vinegar powder and other plant ingredients can stimulate the meridians of the soles of the feet and promote blood circulation through foot patching. Although this will not directly treat oral ulcers, good blood circulation helps various parts of the body to supply nutrients and discharge waste, indirectly promoting oral health; although the foot patch is not a drug that directly treats oral ulcers, it may help reduce the causes of oral ulcers by regulating the overall state of the body, such as improving sleep quality and relieving mental stress.

[0040] The technical solution of the present invention is further described in detail below through the accompanying drawings and embodiments. BRIEF DESCRIPTION OF THE DRAWINGS

[0041] Figure 1 This is the wavelength scanning chromatogram of phenol;

[0042] Figure 2 This is the chromatogram of phenol standard sample;

[0043] Figure 3 is the sample chromatogram;

[0044] Figure 4 This is the linear relationship diagram for the determination of phenol content;

[0045] Figure 5 The fingerprint of the sample. DETAILED DESCRIPTION

[0046] The present invention will be further described below. It should be noted that this embodiment is based on the technical solution and provides a detailed implementation method and a specific operation process, but the present invention is not limited to this embodiment.

[0047] Example 1

[0048] HPLC Analysis of Bamboo Vinegar Powder

[0049] (1) The reagents and manufacturers used are shown in Table 1.

[0050] Table 1 Reagents

[0051]

[0052] (2) Chromatographic test conditions

[0053] Chromatographic column: C18 column; mobile phase: methanol: ultrapure water (1:4); column temperature: 35°C; injection volume: 10 μl;

[0054] Detection wavelength: accurately weigh 0.1g of phenol and put it into a 100ml volumetric flask. Use a rubber-tipped dropper to absorb methanol and add it to the scale line. Then put it into an ultrasonic oscillator and ultrasonically dissolve it for 3 minutes. Take out an appropriate amount of the solution and add it to the injection bottle. Inject the sample for chromatographic scanning and finally determine the detection wavelength to be 270nm. Scan the chromatogram as shown Figure 1 shown.

[0055] (3) Solution preparation

[0056] Preparation of sample solution: Take 1g of bamboo vinegar powder from each company, dissolve it in 49ml of methanol, ultrasonicate for 3min, filter and place in a 100ml volumetric flask, wash with methanol 3 times, and dilute to the mark to obtain the sample solution.

[0057] Preparation of standard solution: Take 0.1041g of phenol, dissolve it in methanol and dilute to 100ml to obtain 1mg / ml phenol solution. Accurately measure 1mg / ml phenol solution and dilute to different volumes to obtain 100μg / ml, 80μg / ml, 50μg / ml, 20mg / ml, and 10mg / ml phenol solutions.

[0058] The chromatograms of the standard solution and sample solution are shown in Figure 2 and Figure 3 .

[0059] (4) Methodological research

[0060] Linearity: Take appropriate amounts of 10μg / ml, 20μg / ml, 50μg / ml, 80μg / ml, and 100μg / ml phenol standard solutions prepared in the solution preparation section and place them in 5 injection bottles for testing. Use the concentration of the phenol standard solution as the horizontal axis and the peak area as the vertical axis to perform linear regression and evaluate the linear range and relationship. The linear relationship of phenol content determination is as follows Figure 4 shown.

[0061] Precision: Take the 20μg / ml phenol standard solution in the solution preparation, inject 10μl, and repeat the injection 5 times. Measure the peak area of ​​each injection and calculate the RSD value of the 5 measurements. The test results are shown in Table 2

[0062] Table 2 Precision test results

[0063]

[0064]

[0065] It can be seen from Table 2 that the RSD calculated from the obtained data is 0.87%, which is less than 5%, indicating good precision.

[0066] Repeatability: Take the Zhongju Biological Grade A powder sample solution prepared in the solution preparation item, inject 10μl, and repeat the injection 5 times. Calculate the RSD value of the peak area of ​​5 injections. The test results are shown in Table 3.

[0067] Table 3 Repeatability test results

[0068]

[0069] From Table 3, it can be seen that the calculated RSD is 0.76%, indicating that the method has good repeatability.

[0070] Stability: The sample solution of Zhongju Biological Grade A powder was tested at 0, 2, 4, and 8 hours, the peak area at different time points was measured, and the RSD value was calculated. The test results are shown in Table 4.

[0071] Table 4 Stability test results

[0072]

[0073] It can be seen from Table 4 that the RSD of the sample solution at different times is 0.73%, indicating that the sample solution is stable within 8 h.

[0074] Recovery rate: Take 0.4g of Zhongju Biological Grade A powder sample, dissolve it in 49ml of methanol, and ultrasonically treat it for 3min. Filter to obtain the filtrate, and dilute it to a 100ml volumetric flask. Take 6 portions of 1ml sample solution, add 1ml of 20μg / ml standard solution to each portion, and dilute to 10ml with methanol. Determine the peak area and calculate the recovery rate based on the concentration of the standard and sample. The test results are shown in Table 5.

[0075] Table 5 Recovery rate experimental results

[0076]

[0077] It can be seen from Table 5 that the calculated recovery rate is 98.19%.

[0078] (5) Sample test results

[0079] Table 6 Sample test results

[0080]

[0081] The fingerprints of Zhongju Biological Grade A Powder (bamboo vinegar powder sample 1), Shukang Biological Grade A Powder (bamboo vinegar powder sample 5), Shukang Biological Grade B Powder (bamboo vinegar powder sample 6) and Haoyuan Biological Grade A Powder (bamboo vinegar powder sample 3) are shown in Figure 5 , Figure 5 From bottom to top they are Zhongju Bio-A, Hebei Shukang-A, Hebei Shukang-B, and Shaanxi Haoyuan-A.

[0082] from Figure 5 It can be seen that the two samples of Zhongju Biological Company and Xi'an Haoyuan Company have a high degree of similarity in fingerprints, and only one representative spectrum is shown. It can be seen from the above figure that there are large differences in the chromatograms of the three manufacturers. It can be determined that the types and quantities of substances contained in the bamboo vinegar powder of different manufacturers are different, so there are also large differences in the role played when used. The fingerprint spectrum of the sample of Zhongju Biological Company shows that the sample contains more ingredients, multiple substance peaks appear in the spectrum, and the content of phenol is higher; the sample of Shaanxi Haoyuan has fewer substance peaks in the spectrum and the content of phenol is lower; the sample of Hebei Shukang Company has more chromatographic peaks within 10 minutes and a larger peak area. It is speculated that it mainly contains a large amount of organic acids and the content of phenol is also low. Based on this, the quality of bamboo vinegar powder can be determined and it is helpful for the selection of bamboo vinegar powder. Therefore, the present invention selects Hebei Shukang A sample (bamboo vinegar powder sample 5) as the main raw material of the foot patch.

[0083] Example 2

[0084] A bamboo vinegar powder foot patch, which comprises the following raw materials in terms of mass percentage:

[0085] Bamboo Vinegar Powder 65%

[0086] Plant extract 15%

[0087] Auxiliary ingredients 20%;

[0088] Auxiliary ingredients include tourmaline, chitosan, nano negative ion powder, Vc and VE, and the mass ratio of the above five substances is 1:1:1:1:1.

[0089] The plant extract is lavender extract.

[0090] The bamboo vinegar powder was bamboo vinegar powder sample 5, grade A, batch number 210213-12, purchased from Hebei Shukang Biotechnology Co., Ltd.

[0091] The preparation process of plant extracts is:

[0092] (1) subjecting lavender Chinese medicinal raw materials to a quality inspection, crushing the qualified raw materials, and passing through a 50-mesh sieve;

[0093] (2) First extraction

[0094] Add the crushed Chinese medicine raw materials into the extraction tank;

[0095] Take deionized water and add it into the extraction tank. The deionized water added is 10 times the weight of the Chinese medicine raw material. After soaking for 30 minutes, heat it to 90°C and keep it warm for 1 hour.

[0096] Cool down to 45°C, filter out the drug residue, and collect the first extract;

[0097] (3) Second extraction

[0098] Add deionized water to the medicine residue, the amount of deionized water added is 8 times the weight of the Chinese medicine raw material, soak for 20 minutes, raise the temperature to 90°C, and keep warm for 2 hours;

[0099] Cool down to 40°C, filter out the drug residue, collect the second extract, and combine it with the first extract to obtain the total extract;

[0100] (4) Concentration and drying

[0101] The combined total extract is concentrated to remove excess water, and dried in a microwave dryer to form an extract;

[0102] (5) Crushing and screening

[0103] The dried extract is crushed and passed through an 80-mesh sieve to obtain Chinese medicine extract powder, i.e., plant extract.

[0104] A method for preparing a bamboo vinegar powder foot patch comprises the following steps:

[0105] (1) Mixing: Add bamboo vinegar powder, plant extract and auxiliary ingredients into a mixer according to a certain proportion, and stir until the mixture is uniform;

[0106] (2) Sieving: Pass the mixed powder through an 80-mesh sieve;

[0107] (3) Bagging: The sieved powder is placed in a medicine bag with one side made of paper and the other side made of non-woven fabric;

[0108] (4) Sealing: Use a heat sealer to seal the bag mouth to obtain a foot patch bag;

[0109] (5) Packaging: The foot patch medicine bag and the additional patch are respectively placed in a sealed bag or a packaging box to obtain the bamboo vinegar powder foot patch.

[0110] Example 3

[0111] A bamboo vinegar powder foot patch, which comprises the following raw materials in terms of mass percentage:

[0112] Bamboo vinegar powder 50%

[0113] Plant extract 30%

[0114] Auxiliary ingredients 20%;

[0115] Auxiliary ingredients include tourmaline, chitosan, nano negative ion powder, Vc and VE, and the mass ratio of the above five substances is 1:1:1:1:1.

[0116] The plant extracts are lavender extract and mugwort leaf extract.

[0117] The bamboo vinegar powder was bamboo vinegar powder sample 5, grade A, batch number 210213-12, purchased from Hebei Shukang Biotechnology Co., Ltd.

[0118] The preparation process of plant extracts is:

[0119] (1) subjecting lavender and wormwood Chinese medicine raw materials to quality inspection, with the mass ratio of lavender to wormwood being 1:1, crushing qualified raw materials and passing through a 50-mesh sieve;

[0120] (2) First extraction

[0121] Add the crushed Chinese medicine raw materials into the extraction tank;

[0122] Take deionized water and add it into the extraction tank. The deionized water added is 12 times the weight of the Chinese medicine raw material. After soaking for 40 minutes, heat it to 100°C and keep it warm for 0.5 hours.

[0123] Cool down to 50℃, filter out the drug residue, and collect the first extract;

[0124] (3) Second extraction

[0125] Add deionized water to the medicine residue, the amount of deionized water added is 10 times the weight of the Chinese medicine raw material, soak for 45 minutes, heat to 95°C, and keep warm for 1 hour;

[0126] Cool down to 50°C, filter out the drug residue, collect the second extract, and combine it with the first extract to obtain the total extract;

[0127] (4) Concentration and drying

[0128] The combined total extract is concentrated to remove excess water, and dried in a microwave dryer to form an extract;

[0129] (5) Crushing and screening

[0130] The dried extract is crushed and passed through an 80-mesh sieve to obtain Chinese medicine extract powder, i.e., plant extract.

[0131] The preparation method of the bamboo vinegar powder foot patch is the same as that of Example 2.

[0132] Example 4

[0133] A bamboo vinegar powder foot patch, which comprises the following raw materials in terms of mass percentage:

[0134] Bamboo vinegar powder 50%

[0135] Plant extract 30%

[0136] Auxiliary ingredients 20%;

[0137] Auxiliary ingredients include tourmaline, chitosan, nano negative ion powder, Vc and VE, and the mass ratio of the above five substances is 1:1:1:1:1.

[0138] The bamboo vinegar powder was bamboo vinegar powder sample 5, grade A, batch number 210213-12, purchased from Hebei Shukang Biotechnology Co., Ltd.

[0139] The plant extracts are lavender extract and evodia rutaecarpa extract.

[0140] The preparation process of plant extracts is:

[0141] (1) subjecting lavender and Evodia rutaecarpa Chinese medicine raw materials to quality inspection, with the mass ratio of lavender to Evodia rutaecarpa being 1:1, crushing qualified raw materials and passing through a 50-mesh sieve;

[0142] (2) First extraction

[0143] Add the crushed Chinese medicine raw materials into the extraction tank;

[0144] Take deionized water and add it into the extraction tank. The deionized water added is 8 times the weight of the Chinese medicine raw material. After soaking for 20 minutes, heat it to 85°C and keep it warm for 1 hour.

[0145] Cool down to 40℃, filter out the drug residue, and collect the first extract;

[0146] (3) Second extraction

[0147] Add deionized water to the medicine residue, the amount of deionized water added is 6 times the weight of the Chinese medicine raw material, soak for 20 minutes, raise the temperature to 85°C, and keep warm for 2 hours;

[0148] Cool down to 40°C, filter out the drug residue, collect the second extract, and combine it with the first extract to obtain the total extract;

[0149] (4) Concentration and drying

[0150] The combined total extract is concentrated to remove excess water, and dried in a microwave dryer to form an extract;

[0151] (5) Crushing and screening

[0152] The dried extract is crushed and passed through an 80-mesh sieve to obtain Chinese medicine extract powder, i.e., plant extract.

[0153] The preparation method of the bamboo vinegar powder foot patch is the same as that of Example 2.

[0154] Example 5

[0155] A bamboo vinegar powder foot patch, which comprises the following raw materials in terms of mass percentage:

[0156] Bamboo vinegar powder 50%

[0157] Plant extract 30%

[0158] Auxiliary ingredients 20%;

[0159] Auxiliary ingredients include tourmaline, chitosan, nano negative ion powder, Vc and VE, and the mass ratio of the above five substances is 1:1:1:1:1.

[0160] The bamboo vinegar powder was bamboo vinegar powder sample 5, grade A, batch number 210213-12, purchased from Hebei Shukang Biotechnology Co., Ltd.

[0161] The plant extracts are lavender extract, platycodon root extract and liquorice extract.

[0162] The preparation process of plant extracts is:

[0163] (1) subjecting lavender, platycodon root and licorice Chinese medicinal raw materials to quality inspection, wherein the mass ratio of lavender, platycodon root and licorice is 1:1:1, and crushing the qualified raw materials and passing through a 50-mesh sieve;

[0164] (2) First extraction

[0165] Add the crushed Chinese medicine raw materials into the extraction tank;

[0166] Take deionized water and add it into the extraction tank. The deionized water added is 10 times the weight of the Chinese medicine raw material. After soaking for 40 minutes, heat it to 90°C and keep it warm for 2 hours.

[0167] Cool down to 42°C, filter out the drug residue, and collect the first extract;

[0168] (3) Second extraction

[0169] Add deionized water to the medicine residue, the amount of deionized water added is 9 times the weight of the Chinese medicine raw material, soak for 25 minutes, raise the temperature to 90°C, and keep warm for 1.5 hours;

[0170] Cool down to 45°C, filter out the drug residue, collect the second extract, and combine it with the first extract to obtain the total extract;

[0171] (4) Concentration and drying

[0172] The combined total extract is concentrated to remove excess water, and dried in a microwave dryer to form an extract;

[0173] (5) Crushing and screening

[0174] The dried extract is crushed and passed through an 80-mesh sieve to obtain Chinese medicine extract powder, i.e., plant extract.

[0175] The preparation method of the bamboo vinegar powder foot patch is the same as that of Example 2.

[0176] Example 6

[0177] A bamboo vinegar powder foot patch, which comprises the following raw materials in terms of mass percentage:

[0178] Bamboo vinegar powder 50%

[0179] Plant extract 30%

[0180] Auxiliary ingredients 20%;

[0181] Auxiliary ingredients include tourmaline, chitosan, nano negative ion powder, Vc and VE, and the mass ratio of the above five substances is 1:1:1:1:1.

[0182] The bamboo vinegar powder was bamboo vinegar powder sample 5, grade A, batch number 210213-12, purchased from Hebei Shukang Biotechnology Co., Ltd.

[0183] The plant extracts are lavender extract, mugwort leaf extract, platycodon root extract, licorice extract and evodia rutaecarpa extract.

[0184] The preparation process of plant extracts is:

[0185] (1) subjecting five Chinese medicinal raw materials, namely lavender, wormwood leaf, platycodon root, liquorice and evodia rutaecarpa, to quality inspection, wherein the mass ratio of the five Chinese medicinal raw materials is 1:1:1:1:1, and the qualified ones are crushed and passed through a 50-mesh sieve;

[0186] (2) First extraction

[0187] Add the crushed Chinese medicine raw materials into the extraction tank;

[0188] Take deionized water and add it into the extraction tank. The deionized water added is 10 times the weight of the Chinese medicine raw material. After soaking for 30 minutes, heat it to 90°C and keep it warm for 1 hour.

[0189] Cool down to 45°C, filter out the drug residue, and collect the first extract;

[0190] (3) Second extraction

[0191] Add deionized water to the medicine residue, the amount of deionized water added is 8 times the weight of the Chinese medicine raw material, soak for 40 minutes, raise the temperature to 95°C, and keep warm for 2 hours;

[0192] Cool down to 50°C, filter out the drug residue, collect the second extract, and combine it with the first extract to obtain the total extract;

[0193] (4) Concentration and drying

[0194] The combined total extract is concentrated to remove excess water, and dried in a microwave dryer to form an extract;

[0195] (5) Crushing and screening

[0196] The dried extract is crushed and passed through an 80-mesh sieve to obtain Chinese medicine extract powder, i.e., plant extract.

[0197] The preparation method of the bamboo vinegar powder foot patch is the same as that of Example 2.

[0198] Comparative Example 1

[0199] The difference from Example 6 is that the bamboo vinegar powder is bamboo vinegar powder sample 1, grade A, batch number 210115-03, purchased from Jiangyin Zhongju Biotechnology Co., Ltd.

[0200] Comparative Example 2

[0201] The difference from Example 6 is that the bamboo vinegar powder is bamboo vinegar powder sample 3, grade A, batch number 210314-05, purchased from Xi'an Haoyuan Biotechnology Co., Ltd.

[0202] Comparative Example 3

[0203] The difference from Example 6 is that the temperature used for the first extraction in the preparation process of the plant extract is 120°C.

[0204] Comparative Example 4

[0205] The difference from Example 6 is that the temperature used for the first extraction in the preparation process of the plant extract is 60°C.

[0206] Performance Testing

[0207] (1) 50 subjects with basically the same physical conditions were selected and divided into 10 groups, with 5 subjects in each group. The subjects were respectively given the foot patches prepared in Examples 2-6 and Comparative Examples 1-4, and then the weight gain of the foot patches after use was tested.

[0208] Instructions: Soak your feet for 15 minutes until the soles of your feet are slightly sweaty, then dry your feet, tear off the sticker from the foot patch, find the Yongquan acupoint and apply it, making sure that the side with the small hole in the powder bag faces the sole of the foot, apply it before going to bed and remove it after getting up, and apply it for 8 hours. During the study, weigh the foot patch before use, take it on after getting up the next day, and weigh it again to determine the accurate weight change. The weight increase is used as the main indicator to evaluate the product's dehumidification and detoxification effects, and the average value is taken from 5 people in each group. The test results are shown in Table 7.

[0209] Table 7 Test results of dehumidification and detoxification effect

[0210]

[0211]

[0212] (2) Observation of therapeutic efficacy in patients with oral ulcers

[0213] 50 young people with oral ulcers were selected for efficacy observation and divided into 10 groups, with 5 people in each group. They used the foot patches prepared in Examples 2-6 and Comparative Examples 1-4 respectively. The method of use was to wash feet with warm water every night, take two patches and stick them on the Yongquan acupoints on the soles of the feet respectively, remove them in the morning of the next day (the usage time was 8 hours), wipe them clean, and apply them continuously for 5 days as a course of treatment.

[0214] Inclusion criteria for patients with oral ulcers:

[0215] ① The patient has a history of oral ulcers for at least half a year.

[0216] ②Recurrent attacks, at least once every two months.

[0217] ③The ulcer lasts no longer than 3 days.

[0218] ④ Subjects who are willing and able to cooperate in completing the trial.

[0219] The scoring criteria are shown in Table 8.

[0220] Table 8 Scoring criteria for oral ulcers

[0221]

[0222]

[0223] The test group's feedback results show that the foot patch prepared in Examples 2-6 has the effects of reducing pain, shortening recovery time, etc. The test score results are shown in Table 9.

[0224] Table 9 Oral ulcer treatment results

[0225]

[0226]

[0227] Clinical trials:

[0228] Feng**, 19 years old, female, had the following symptoms: 3 oral ulcers, which were small and round with red edges. The score was 21 points before use according to Table 8. The foot patch prepared in Example 6 was applied for 4 days from December 25 to December 28 according to the above method of use. The score after use was 1 point.

[0229] Mu**, 20 years old, female, had symptoms of 2 oral ulcers, not too big, with slightly red edges, scored according to Table 8, and applied the foot patch prepared in Example 2 for 3 days from December 24 to December 26 according to the above method of use. The score after use was 7 points.

[0230] Liu**, 20 years old, male, symptom: oral ulcer, scored according to Table 8, the score before use was 12 points, and the foot patch prepared in Example 3 was applied for 4 days from December 24 to December 27 according to the above method of use, and the score after use was 3 points.

[0231] Zhuang**, 20 years old, male, symptom: oral ulcer, scored according to Table 8, the score before use was 13 points, and the foot patch prepared in Example 3 was applied for 4 days from December 25 to December 28 according to the above method of use, and the score after use was 0 points.

[0232] (3) Observation of therapeutic effects on patients with internal heat

[0233] 50 young people with symptoms of getting angry were selected for efficacy observation and divided into 10 groups, with 5 people in each group. They used the foot patches prepared in Examples 2-6 and Comparative Examples 1-4 respectively. The method of use was to wash feet with warm water every night, take two patches and stick them on the Yongquan acupoints on the soles of the feet respectively, remove them in the early morning of the next day (the usage time was 8 hours), wipe them clean, and apply them continuously for 5 days as a course of treatment.

[0234] Inclusion criteria for patients with internal heat:

[0235] ① Patients with acute tonsillitis, tonsillar abscess, acute pharyngitis and simple laryngitis.

[0236] ② Sore throat caused by viral, bacterial infection or physical and chemical factors.

[0237] ③ Subjects who are willing and able to cooperate in completing the trial.

[0238] Effect evaluation criteria:

[0239] Cure criteria: After treatment, pain disappears, mucosal congestion completely subsides, and related functions return to normal.

[0240] Improvement criteria: Symptoms and signs have improved, and functions have basically returned to normal.

[0241] Ineffective situation: There is no significant change in symptoms before and after treatment.

[0242] The symptoms of many patients suffering from internal heat who used the foot patch of Examples 2-6 improved, and a small number of patients were cured, indicating that this prescription has an annealing effect.

[0243] Clinical trials:

[0244] Ma**, 19 years old, female, symptoms: swollen and painful gums, with symptoms of getting angry, used the foot patch prepared in Example 4, from December 24, 2019 to December 26, 2019. After three days of use, the symptoms and signs improved, and the functions basically returned to normal.

[0245] Huang*, 21 years old, female, symptoms: sore throat, frequent dreams, dizziness, and symptoms of getting angry. The foot patch prepared in Example 4 was applied from December 25, 2019 to December 27, 2019. After three days of use, the symptoms and signs improved, and the functions basically returned to normal.

[0246] Tong**, 20 years old, male, symptoms: sore throat, with symptoms of getting angry, used the foot patch prepared in Example 4, from December 24, 2019 to December 27, 2019, and after four days of use, the symptoms and signs improved, and the functions basically returned to normal.

[0247] Wang**, 21 years old, male, symptoms: sore throat, with symptoms of getting angry, used the foot patch prepared in Example 4, from December 25, 2019 to December 27, 2019. After three days of use, the symptoms and signs improved, and the functions basically returned to normal.

[0248] Jia**, 19 years old, female, symptoms: sore throat, bleeding gums, and symptoms of getting angry. She used the foot patch prepared in Example 4 from December 25, 2019 to December 28, 2019. After four days of use, she no longer felt pain, mucosal congestion subsided, and her function returned to normal.

[0249] Wang**, 19 years old, female, symptoms: swollen and painful gums, sore throat, and symptoms of getting angry. The foot patch prepared in Example 4 was applied from December 24, 2019 to December 26, 2019. After three days of use, the symptoms and signs improved, and the functions basically returned to normal.

[0250] Yang**, 20 years old, female, symptoms: sore throat, accompanied by slight redness and swelling, with symptoms of getting angry, used the foot patch prepared in Example 4, from December 24, 2019 to December 26, 2019, and after three days of use, there was no more pain, mucosal congestion subsided, and function returned to normal.

[0251] Therefore, the present invention adopts a bamboo vinegar powder foot patch with the above structure and a preparation method thereof. The prepared bamboo vinegar powder foot patch can stimulate the meridians of the sole of the foot, promote blood circulation, and help relieve fatigue and pain caused by poor blood circulation. Plant components such as lavender extract and wormwood extract are rich in natural aromatic substances, have the effects of calming the nerves and relieving tension, and also have a good improvement effect on patients with oral ulcers and patients with internal heat.

[0252] Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention rather than to limit it. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that they can still modify or replace the technical solution of the present invention with equivalents, and these modifications or equivalent replacements cannot cause the modified technical solution to deviate from the spirit and scope of the technical solution of the present invention.

Claims

1. A bamboo vinegar powder foot patch, characterized in that: Bamboo vinegar powder foot patch includes the following raw materials in terms of mass percentage: Bamboo vinegar powder 50-65% Plant extract 15-30% Auxiliary ingredients 15-25%; The plant extract is one or more of lavender extract, wormwood leaf extract, platycodon root extract, licorice extract and evodia rutaecarpa extract.

2. The bamboo vinegar powder foot patch according to claim 1, characterized in that: The preparation process of plant extracts is: (1) Conduct quality inspection on one or more Chinese medicinal raw materials selected from lavender, wormwood leaf, platycodon root, licorice or evodia rutaecarpa, and crush the qualified raw materials and pass them through a 50-mesh sieve; (2) First extraction Add the crushed Chinese medicine raw materials into the extraction tank; Take deionized water and add it to the extraction tank. After soaking for 10 to 50 minutes, heat it to 85 to 100°C and keep it warm for 0.5 to 2 hours. Cool down to 40-50℃, filter out the drug residue, and collect the first extract; (3) Second extraction Add deionized water to the drug residue, soak for 10 to 50 minutes, raise the temperature to 85 to 100° C., and keep warm for 0.5 to 2 hours; Cool down to 40-50°C, filter out the drug residue, collect the second extract, and combine it with the first extract to obtain the total extract; (4) Concentration and drying The combined total extract is concentrated to remove excess water, and dried in a microwave dryer to form an extract; (5) Crushing and screening The dried extract is crushed and passed through an 80-mesh sieve to obtain Chinese medicine extract powder, i.e., plant extract.

3. The bamboo vinegar powder foot patch according to claim 2, characterized in that: The amount of deionized water added in step (2) is 5 to 15 times the weight of the Chinese medicinal raw material.

4. The bamboo vinegar powder foot patch according to claim 2, characterized in that: The amount of deionized water added in step (3) is 5 to 10 times the weight of the Chinese medicinal raw material.

5. The bamboo vinegar powder foot patch according to claim 1, characterized in that: The auxiliary components are one or more of tourmaline, chitin, nano negative ion powder, Vc and VE.

6. The method for preparing a bamboo vinegar powder foot patch according to any one of claims 1 to 5, characterized in that: The following steps are involved: (1) Mixing: Add bamboo vinegar powder, plant extract and auxiliary ingredients into a mixer according to the proportion, and stir until the mixture is uniform; (2) Sieving: Pass the mixed powder through an 80-mesh sieve; (3) Bagging: Put the sieved powder into a medicine bag with one side of paper and the other side of non-woven fabric; (4) Sealing: Use a heat sealer to seal the bag mouth to obtain a foot patch bag; (5) Packaging: The foot patch medicine bag and the additional patch are respectively placed in a sealed bag or packaging box to obtain the bamboo vinegar powder foot patch.

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