Micro-catheter for hepatic artery perfusion chemotherapy
Patent Information
- Application Number
- CN202411543468.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-10-31
- Publication Date
- 2024-12-20
AI Technical Summary
In the chemotherapy of hepatic artery perfusion, the drug laminar flow caused by end adherence, the drug is not fully mixed, and it is prone to dislocation, which affects the treatment effect and causes side effects.
Design a pig tail-shaped curly microcatheter with lateral holes and end holes at the end, through which drugs flow into the blood vessels to avoid laminar flow, and adapt to the angle between the common hepatic artery and the inherent artery of the hepatic artery through the bent section to ensure the catheter Stable assertion.
The uniform release of drugs in the hepatic artery is achieved, the effect of hepatic artery perfusion chemotherapy is improved, the ectopic perfusion of drugs and catheter dislocation is avoided, and the depth and safety of treatment are enhanced.
Smart Images
Figure CN119158143A_ABST
Abstract
Description
Technical Field
[0001] The invention relates to the field of medical technology, and in particular to a microcatheter used for hepatic artery perfusion chemotherapy. Background Art
[0002] Hepatic Artery Infusion Chemotherapy (HAIC) is an interventional treatment method that infuses chemotherapy drugs through the hepatic artery to increase the drug concentration in liver tumors and thus improve the anti-tumor effect. HAIC can kill tumor cells to the greatest extent, and chemotherapy drugs have little effect on normal liver tissue and fewer systemic adverse reactions. With the publication of more and more research results on HAIC treatment of hepatocellular carcinoma, its effectiveness has been confirmed, and HAIC treatment has become more and more popular. The main method of HAIC treatment is to selectively insert a microcatheter into the proper hepatic artery or the main blood supply artery of the tumor, especially catheterization in the proper hepatic artery is the most commonly used.
[0003] like Figure 5-Figure 7 As shown, the existing microcatheters are straight-headed or swan-necked. However, when the proper hepatic artery is catheterized for perfusion, the end of the microcatheter adheres to the wall, and the drug perfused through the microcatheter adheres to the blood vessel wall to produce drug laminar flow. However, the proper hepatic artery is short, and the drug and blood do not have time to fully mix, and most of the drug enters the hepatic artery branch on the side attached to the wall (usually the right hepatic artery). At the same time, hepatic artery perfusion chemotherapy strictly limits the end of the catheter to the proper hepatic artery or the main blood supply branch of the tumor. If the proper hepatic artery is too short and / or thick, the end of the catheter is easily dislocated, and the drug will mistakenly enter the gastroduodenal artery, left / right gastric artery and other blood vessels, affecting the effect of perfusion chemotherapy, and easily causing gastrointestinal damage and causing abdominal pain, vomiting and other symptoms. Summary of the invention
[0004] In view of this, it is necessary to propose a microcatheter for hepatic artery infusion chemotherapy.
[0005] An embodiment of the present invention provides a microcatheter for hepatic artery perfusion chemotherapy, wherein the microcatheter is placed in the proper hepatic artery through the common hepatic artery, an injection port is provided at the head end of the microcatheter, a distal tube section is formed at a position of a preset length from the injection port, and the end of the distal tube section forms a pigtail-shaped curled tube tail section; the tube tail section is curled in a pigtail shape, a plurality of side holes are arranged at intervals on the tube tail section, and an end hole is arranged at the end of the tube tail section; the end hole faces the inner side of the tube tail section as the tube tail section curls; when the drug is injected into the microcatheter from the injection port, the drug flows out from the side holes and the end hole and enters the target position.
[0006] Optionally, the tube tail section is curled in a pigtail shape for one or more turns; and the end hole is located in the middle of the curled tube tail section.
[0007] Optionally, when the drug flows out of the end holes and the side holes, the drug is confined to only within the proper hepatic artery.
[0008] Optionally, the distal tube section is formed by bending the microcatheter, the distal tube section includes a smoothly bent section away from the tail section, the angle between the common hepatic artery and the proper hepatic artery is adapted to the bending angle of the smoothly bent section, the microcatheter is adaptively placed on the common hepatic artery and the proper hepatic artery with the distal tube section, and the tail section is located at one end of the proper hepatic artery away from the common hepatic artery.
[0009] Optionally, the distal end of the tube includes a vertical tube body section connected to the end of the tube tail section away from the end hole, and a horizontal tube body section connected to the vertical tube body section by relative bending, the injection port is arranged at the head end of the horizontal tube body section away from the vertical tube body section, and the tube tail section is curled downward from the end of the vertical tube body section.
[0010] Optionally, the length of the vertical tube section is 15-25 mm.
[0011] Optionally, the curling diameter of the tube tail section is 3-5 mm.
[0012] Optionally, the tube tail section is provided with a mark, so that when the microcatheter is placed in the proper hepatic artery, a detection device can obtain the position of the tube tail section in the proper hepatic artery through the mark.
[0013] Optionally, the microcatheter is placed in the proper hepatic artery in a straight line under the guidance of a guide wire; when the guide wire is retrieved, the microcatheter returns to its original shape in the proper hepatic artery.
[0014] Optionally, the injection port is adapted and fixed to a drug delivery device so that the drug can be injected into the microcatheter.
[0015] The microcatheter for hepatic artery perfusion chemotherapy is provided with an end hole and a plurality of side holes in the tail section of the tube curled in a pigtail shape, and an injection port for injecting drugs into the microcatheter is provided at the head end of the tube so that the drugs can enter the microcatheter and enter the target position of the blood vessel through the side holes and the end holes, and then applied to hepatic artery perfusion chemotherapy. The tail section of the microcatheter is curled in the shape of a pigtail in the proper hepatic artery, and the curled section is provided with side holes and end holes, so that the drugs can be evenly released into the blood vessel, avoiding the occurrence of laminar flow, thereby improving the effect of hepatic artery perfusion chemotherapy. And because the laminar flow phenomenon is avoided, the tube can be placed more deeply at the distal end of the proper hepatic artery, making it difficult to dislocate. In addition, the bending angle of the distal section of the tube is used to conform to the angle between the common hepatic artery and the proper hepatic artery, so that the microcatheter is not easy to slip or move in the proper hepatic artery, avoiding the situation of ectopic drug perfusion. BRIEF DESCRIPTION OF THE DRAWINGS
[0016] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on the structures shown in these drawings without paying creative work.
[0017] Figure 1 A schematic structural diagram of a microcatheter provided in an embodiment of the invention.
[0018] Figure 2 A schematic structural diagram of the distal section of a microcatheter tube provided in an embodiment of the invention.
[0019] Figure 3 A schematic diagram of a microcatheter usage scenario provided for an embodiment of the invention.
[0020] Figure 4 Schematic diagram of drug outflow from a microcatheter provided in an embodiment of the invention.
[0021] Figure 5 Schematic diagram of existing microcatheter usage scenarios.
[0022] Figure 6 Schematic diagram of drug laminar flow during the existing microcatheter perfusion process.
[0023] Figure 7 This is a schematic diagram of the existing microcatheter removal.
[0024] Component number
[0025] Microcatheter-100 Left hepatic artery-4
[0026] Existing microcatheter-100' right hepatic artery-5
[0027] Distal tube-1 Gastroduodenal artery-6
[0028] Injection port-11 Common hepatic artery-7
[0029] Vertical tube segment-12 Right gastric artery-8
[0030] Horizontal pipe section-13 Drug laminar flow-9
[0031] Tube tail section-2 Preset length-H1
[0032] End hole-21 Length of vertical pipe section-H2
[0033] Side hole-22 Curl diameter-H3
[0034] Mark-23 End hole diameter-H4
[0035] Hepatic artery-3 Distal outer diameter of the tube-H5
[0036] The realization of the purpose, functional features and advantages of the present invention will be further explained in conjunction with embodiments and with reference to the accompanying drawings. DETAILED DESCRIPTION
[0037] In the description of the present invention, it should be understood that the terms "length", "width", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside" and "outside" etc., indicating orientations or positional relationships, are orientations or positional relationships based on the drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present invention.
[0038] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implying the number of technical features indicated by the term. Therefore, a feature defined as "first" or "second" may explicitly or implicitly include one or more of the features. In the description of the present invention, the meaning of "plurality" is two or more, unless otherwise clearly and specifically defined.
[0039] In the present invention, unless otherwise clearly specified and limited, the terms "installed", "connected", "connected", "fixed" and the like should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.
[0040] In order to make the content of the present invention more clearly and more accurately understood, it will now be described in detail with reference to the accompanying drawings. The accompanying drawings in the specification illustrate examples of embodiments of the present invention, wherein the same reference numerals represent the same elements. It is understood that the scales shown in the accompanying drawings in the specification are not the scales of the actual implementation of the present invention, and are only for the purpose of illustrative description, and are not drawn according to the original size.
[0041] Please see Figure 1, which is a schematic diagram of the structure of a microcatheter for hepatic artery infusion chemotherapy provided in an embodiment of the invention. An embodiment of the present invention provides a microcatheter 100 for hepatic artery infusion chemotherapy (HAIC). The microcatheter 100 is placed in the proper hepatic artery 3 through the common hepatic artery 7. Among them, the microcatheter 100 is made of a flexible material, such as a polyetheramide polymer (PEBAX), polyethylene, etc. An injection port 11 is provided at the head end of the microcatheter 100. The microcatheter 100 forms a distal tube section 1 at a position of a preset length H1 from the injection port 11 at the head end. The end of the distal tube section 1 forms a pigtail-shaped curled tube tail section 2. The tube tail section 2 and the tube distal section 1 are interconnected to form a pipeline for delivering drugs. Among them, the tube tail section 2 is provided with a plurality of side holes 22 at intervals, and an end hole 21 is provided at the end of the tube tail section 2. The microcatheter 100 is connected to a drug delivery device (not shown) through the injection port 11, so that the drug of the drug delivery device is injected into the microcatheter 100 from the injection port 11, and flows out from the end hole 21 and the side hole 22 to the blood vessel and enters the target position. Among them, the end hole 21 is located at the center of the tube tail section 2 toward the inner side of the tube tail section 2 as the tube tail section 2 curls, so that the end hole 21 is located at the center of the blood vessel, that is, the center of the proper hepatic artery 3. Several side holes 22 allow the drug to flow into the blood vessel in a dispersed manner to avoid laminar flow of the drug in the blood vessel. In this embodiment, several side holes 22 are arranged at equal intervals. The preset length H1 is determined according to the target position during HAIC and configured to different lengths. Optionally, the preset length H1 is configured to be 120 cm. It can be understood that in other embodiments, the intervals between several side holes 22 are different. In addition, the microcatheter 100 is flexible, so that the microcatheter 100 can be placed into the blood vessel in different forms during guidance, thereby improving the convenience of placing the microcatheter 100 into the blood vessel. How to guide the microcatheter 100 will be described in detail below.
[0042] In this embodiment, the tube tail section 2 is curled in a pigtail shape for one or more turns so that the end hole 21 is located in the middle of the curling of the tube tail section 2. It is understandable that the tube tail section 2 can be curled in a clockwise direction for one or more turns so that the end of the tube tail section 2 curls inwards, thereby making the end hole 21 located in the middle of the curling of the tube tail section 2, or it can be curled in a counterclockwise direction for one or more turns so that the end of the tube tail section 2 curls inwards, thereby making the end hole 21 located in the middle of the curling of the tube tail section 2. In other words, the curling method of the tube tail section 2 in this embodiment is only an example of the curling method and number of turns of the tube tail section 2, rather than a limitation on the curling method and number of turns of the tube tail section 2. Furthermore, the tube tail section 2 is curled in a spiral manner so that the end hole 21 is located in the middle of the curling of the tube tail section 2, and the end hole 21 faces upwards and a number of side holes 22 are also distributed in a curve as the tube tail section 2 bends. When the drug flows out from the end hole 21 and the side hole 22, the drug is confined only in the proper hepatic artery 3. The curling diameter H3 of the tube tail section 2 is 3-5 mm.
[0043] In this embodiment, the distal tube section 1 is formed by bending the microcatheter 100. The distal tube section 1 includes a smooth bending section away from the tail section 2. The angle between the common hepatic artery 7 and the proper hepatic artery 3 is adapted to the bending angle of the tail section 1, so that when the microcatheter 100 is placed in the proper hepatic artery 3, the position between the microcatheter 100 and the blood vessels in the proper hepatic artery 3 is fixed by the bending angle. The distal tube section 1 is pre-shaped into a "C" shape, but is not limited to a "C" shape, a "U" shape, a "V" shape or a straight shape. The microcatheter 100 is adaptively placed in the common hepatic artery 7 and the proper hepatic artery 3 with the distal tube section 1. When the microcatheter 100 is correctly placed in the proper hepatic artery 3, the tail section 2 is located at the end of the proper hepatic artery 3 away from the common hepatic artery 7. The microcatheter 100 conforms to the angle formed by the proper hepatic artery 3 and the common hepatic artery 7 through the bending angle of the distal tube section 1, so that the distal tube section 1 of the microcatheter 100 is not easy to dislocate. In this embodiment, the end hole diameter H4 is smaller than the outer diameter H5 of the distal tube section, the end hole diameter H4 is 0.85 mm-0.93 mm, and the outer diameter H5 of the distal tube section is 0.88 mm-1.00 mm.
[0044] In this embodiment, the pipe distal section 1 includes a vertical pipe body section 12 connected to the end of the pipe tail section 2 away from the end hole 21, and a horizontal pipe body section 13 relatively bent and connected to the vertical pipe body section 12. The injection port 11 is arranged at the head end of the horizontal pipe body section 13 away from the vertical pipe body section 12. The pipe tail section 2 is formed by curling downward from the end of the vertical pipe body section 12. The length H2 of the vertical pipe body section 12 is 15-25 mm. In other embodiments, the pipe distal section 1 can also be straight as a whole.
[0045] In this embodiment, the microcatheter 100 is also provided with a plurality of marks 23. Specifically, the plurality of marks 23 are provided on the tube tail section 2, so that when the microcatheter 100 is placed in the proper hepatic artery 3, the detection device (not shown) can obtain the position of the tube tail section 2 in the proper hepatic artery 3 through the marks 23. It can be understood that the marks 23 are configured as the same mark or different marks according to design requirements, so that when the detection device recognizes the marks 23, the position of the tube tail of the microcatheter 100 can be determined according to the marks 23. In some feasible embodiments, the marks 23 can also be provided on the inner wall of the tube tail section 2 and / or the distal tube section 1.
[0046] In this embodiment, when injecting drugs into the proper hepatic artery 3 of the patient, the microcatheter 100 is firstly straightened by using a guide wire (not shown), that is, the microcatheter 100 is placed in the proper hepatic artery in a straight line under the guidance of the guide wire, that is, the tail section 2 and the distal section 1 of the tube are straightened under the guidance of the guide wire, so that the microcatheter 100 can be smoothly introduced into the blood vessel; then, the microcatheter 100 is introduced into the proper hepatic artery 3 under the guidance of the guide wire and is introduced into the appropriate position with the assistance of the detection equipment. The microcatheter 100 is placed in the proper hepatic artery 3, that is, the tail section 2 of the tube is located at one end of the proper hepatic artery 3 away from the common hepatic artery 7, and the angle between the common hepatic artery 7 and the proper hepatic artery 3 is adapted to the bending angle of the distal section 1 of the tube; then, the guide wire is recovered, and when the guide wire is recovered, the microcatheter 100 is restored to its original state in the proper hepatic artery 3, that is, the tail section 2 of the tube is restored to a pigtail shape, and the distal section 1 of the tube is restored to a bent shape, thereby limiting the microcatheter 100 to the hepatic artery; finally, the injection port 11 is adapted and fixed to the drug delivery device so that the drug can be injected into the microcatheter 100. When the drug is injected into the microcatheter 100 from the injection port 11, the drug flows out from the side hole 22 and the end hole 21 and enters the target position. At this time, the tail section 2 of the microcatheter 100 is curled in the proper hepatic artery 3 in the shape of a pigtail. The following will specifically describe the application scenarios of the prior art and the microcatheter provided by the present application when placed in the proper hepatic artery 3 in conjunction with the accompanying drawings.
[0047] like Figure 6 As shown, when the existing microcatheter 100' is placed in the proper hepatic artery 3, the end of the microcatheter 100' is close to the blood vessel wall (usually the right side wall). At this time, the drug infused through the microcatheter 100' adheres to the blood vessel wall to generate a drug laminar flow 9. However, since the proper hepatic artery 3 is short, the drug does not have time to mix with the blood and enters the wall-adherent artery branch (usually the right hepatic artery 5) in the form of a drug laminar flow 9. Figure 5 and Figure 7 As shown, when the microcatheter 100' is placed in the proper hepatic artery 3, the end of the microcatheter 100' must be strictly limited to be located in the proper hepatic artery 3. If the proper hepatic artery 3 is too short or thick, the end of the microcatheter 100' is easily dislocated in the proper hepatic artery 3, causing part of the drug to flow into the proximal branch blood vessels, or even the end of the tube directly enters the proximal branch blood vessels (such as the gastroduodenal artery 6, the right gastric artery 8, the left gastric artery, etc.), thereby affecting the drug perfusion effect and aggravating the side effects.
[0048] And as Figure 4As shown, after the microcatheter 100 is placed in the proper hepatic artery 3, when the drug flows in the proper hepatic artery 3 according to the blood flow direction shown in the figure, the drug will flow out from the side hole 22 and the end hole 21, and flow evenly to the left hepatic artery 4 and the right hepatic artery 5 with the blood flow. Moreover, since the end hole 2 of the tube is provided with the end hole 21 and the side hole 22, the drug entering the proper hepatic artery 3 can be distributed more evenly in the proper hepatic artery 3, avoiding the occurrence of laminar flow, thereby improving the effect of HAIC. In addition, because the laminar flow phenomenon is avoided, the microcatheter 100 can be placed more deeply in the distal end of the proper hepatic artery 3, making it difficult to dislocate. In addition, the bending angle of the distal tube section 1 is used to conform to the angle between the common hepatic artery 7 and the proper hepatic artery 3, so that the microcatheter 100 is not easy to slip or move in the proper hepatic artery 3, avoiding the occurrence of ectopic drug perfusion. Therefore, the microcatheter 100 provided in the present application can be applied to HAIC.
[0049] In the above embodiment, the end hole and several side holes are provided in the tail section of the tube curled in the shape of a pigtail, and the injection port for injecting drugs into the microcatheter is provided at the head end of the tube, so that the drugs can enter the microcatheter and enter the target position of the blood vessel through the side holes and the end holes, and then be applied to hepatic artery perfusion chemotherapy. The tail section of the microcatheter is curled in the shape of a pigtail in the proper hepatic artery, and the curled section is provided with side holes and end holes, so that the drugs can be evenly released into the blood vessel, avoiding the occurrence of laminar flow, thereby improving the effect of hepatic artery perfusion chemotherapy. And because the laminar flow phenomenon is avoided, the tube can be placed deeper at the distal end of the proper hepatic artery, making it difficult to dislocate. In addition, the bending angle of the distal section of the tube conforms to the angle between the common hepatic artery and the proper hepatic artery, so that the microcatheter is not easy to slip or move in the proper hepatic artery, avoiding the situation of ectopic perfusion of drugs.
[0050] Obviously, those skilled in the art can make various changes and modifications to the present invention without departing from the spirit and scope of the present application. Thus, if these modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include these modifications and variations.
[0051] The above examples are only preferred embodiments of the present invention, and certainly cannot be used to limit the scope of the present invention. Therefore, equivalent changes made according to the claims of the present invention still fall within the scope of the present invention.
Claims
1. A microcatheter for hepatic artery infusion chemotherapy, wherein the microcatheter is placed in the proper hepatic artery via the common hepatic artery, characterized in that: The head end of the microcatheter is provided with an injection port, the microcatheter forms a distal tube section at a preset length from the injection port, and the end of the distal tube section forms a pigtail-shaped curled tube tail section; the tube tail section is provided with a plurality of side holes at intervals and an end hole is provided at the end of the tube tail section; the end hole faces the inner side of the tube tail section as the tube tail section curls; when the drug is injected into the microcatheter from the injection port, the drug flows out from the side holes and the end hole and enters the target position.
2. The microcatheter for hepatic artery infusion chemotherapy according to claim 1, characterized in that: The tube tail section is curled in one or more circles in a pigtail shape; the end hole is located in the middle of the curling of the tube tail section.
3. The microcatheter for hepatic artery infusion chemotherapy according to claim 2, characterized in that: When the drug flows out from the end holes and the side holes, the drug is confined only within the proper hepatic artery.
4. The microcatheter for hepatic artery infusion chemotherapy according to claim 3, characterized in that: The distal tube section is formed by bending the microcatheter, and the distal tube section includes a smoothly bent section away from the tail section of the tube. The angle between the common hepatic artery and the proper hepatic artery matches the bending angle of the smoothly bent section. The microcatheter is adaptively placed on the common hepatic artery and the proper hepatic artery with the distal tube section, and the tail section of the tube is located at one end of the proper hepatic artery away from the common hepatic artery.
5. The microcatheter for hepatic artery infusion chemotherapy according to claim 4, characterized in that: The distal end of the tube includes a vertical tube section connected to one end of the tube tail section away from the end hole, and a horizontal tube section connected to the vertical tube section by relative bending. The injection port is arranged at the head end of the horizontal tube section away from the vertical tube section, and the tube tail section is curled downward from the end of the vertical tube section.
6. The microcatheter for hepatic arterial infusion chemotherapy according to claim 5, characterized in that: The length of the vertical tube section is 15-25 mm.
7. The microcatheter for hepatic arterial infusion chemotherapy according to claim 4, characterized in that: The curling diameter of the tube tail section is 3-5 mm.
8. The microcatheter for hepatic arterial infusion chemotherapy according to claim 1, characterized in that: The tube tail section is provided with a mark, so that when the microcatheter is placed in the proper hepatic artery, a detection device can obtain the position of the tube tail section in the proper hepatic artery through the mark.
9. The microcatheter for hepatic arterial infusion chemotherapy according to claim 1, characterized in that: The microcatheter is placed in the proper hepatic artery in a straight line under the guidance of the guide wire; when the guide wire is recovered, the microcatheter returns to its original shape in the proper hepatic artery.
10. The microcatheter for hepatic arterial infusion chemotherapy according to any one of claims 1 to 9, characterized in that: The injection port is adapted and fixed to the drug delivery device so that the drug can be injected into the microcatheter.