Micro-catheter for hepatic artery perfusion chemotherapy

Abstract

The utility model provides a microcatheter for hepatic artery perfusion chemotherapy, which is characterized in that the microcatheter is arranged in an inherent artery of a liver through a common artery of the liver, an injection port is arranged at the head end of the microcatheter, a catheter far section is formed at a position, which is away from the injection port by a preset length, of the microcatheter, and a pigtail-shaped curled catheter tail section is formed at the tail end of the catheter far section; a plurality of side holes are formed in the pipe tail section at intervals, and an end hole is formed in the tail end of the pipe tail section; the end hole faces the inner side of the pipe tail section along with the curling of the pipe tail section; when medicine is injected into the micro catheter from the injection port, the medicine flows out of the side hole and the end hole and enters a target position. According to the technical scheme, after the catheter tail section of the micro catheter is placed in the preset position of the inherent artery of the liver under the guidance of the guide wire, the guide wire is pulled away, the catheter far section is in a smooth bending shape, and the catheter tail section is curled in a pigtail shape, so that the catheter conforms to the shape of a blood vessel, and the effects that the catheter is not prone to falling off, the catheter can be placed more deeply and medicine is evenly released can be achieved.

Description

Technical Field

[0001] This utility model relates to the field of medical technology, and in particular to a microcatheter for hepatic artery perfusion chemotherapy. Background Technology

[0002] Hepatic artery infusion chemotherapy (HAIC) is an interventional treatment method that involves infusing chemotherapy drugs via the hepatic artery to increase the drug concentration in liver tumors, thereby enhancing the anti-tumor effect. HAIC can maximize the killing of tumor cells, and the chemotherapy drugs have minimal impact on normal liver tissue, resulting in fewer systemic adverse reactions. With the increasing publication of research findings on HAIC treatment for hepatocellular carcinoma, confirming its effectiveness, HAIC treatment is becoming more and more widespread. The main method of HAIC treatment involves selectively inserting a microcatheter into the proper hepatic artery or the main blood supply artery of the tumor, with catheterization in the proper hepatic artery being the most common approach.

[0003] like Figures 5-7 As shown, existing microcatheters are either straight-tipped or swan-neck shaped. However, during perfusion via the proper hepatic artery, the microcatheter tip adheres to the vessel wall, resulting in laminar flow of the infused drug. Since the proper hepatic artery is relatively short, the drug does not have sufficient time to mix with the blood, and most of the drug enters the hepatic artery branch on the side adhering to the wall (usually the right hepatic artery). Furthermore, hepatic artery perfusion chemotherapy strictly limits the catheter tip to within the proper hepatic artery or the main blood supply branch to the tumor. If the proper hepatic artery is too short and / or too large, the catheter tip is prone to dislocation, and the drug may accidentally enter the gastroduodenal artery, left / right gastric artery, or other vessels, affecting the efficacy of the perfusion chemotherapy and easily causing gastrointestinal damage, leading to symptoms such as abdominal pain and vomiting. Utility Model Content

[0004] In view of this, it is necessary to propose a microcatheter for hepatic artery perfusion chemotherapy.

[0005] This invention provides a microcatheter for hepatic artery perfusion chemotherapy. The microcatheter is placed in the proper hepatic artery via the common hepatic artery. The tip of the microcatheter has an injection port. A distal segment is formed at a predetermined length from the injection port. The end of the distal segment is a pig-tail-shaped curled tail segment. The tail segment has several side holes spaced apart and an end hole at its end. The end hole faces inwards from the curled tail segment. When medication is injected into the microcatheter through the injection port, the medication flows out from the side holes and the end hole and enters the target location.

[0006] Optionally, the tail section of the tube is curled up in a pig's tail shape one or more times; the end hole is located in the middle of the curled tail section.

[0007] Optionally, when the drug flows out from the end port and side port, the drug is confined only within the proper hepatic artery.

[0008] Optionally, the distal segment is formed by bending the microcatheter, and the distal segment includes a smooth bend away from the tail segment. The angle between the common hepatic artery and the proper hepatic artery is adapted to the bending angle of the smooth bend segment. The microcatheter is adapted to be placed in the common hepatic artery and the proper hepatic artery with the distal segment, and the tail segment is located at the end of the proper hepatic artery away from the common hepatic artery.

[0009] Optionally, the distal section of the tube includes a vertical tube section connected to the end of the distal section away from the end hole, and a horizontal tube section that is bent and connected to the vertical tube section. The injection port is located at the head end of the horizontal tube section away from the vertical tube section, and the distal section is formed by curling downward from the end of the vertical tube section.

[0010] Optionally, the length of the vertical tube section is 15-25 mm.

[0011] Optionally, the curling diameter of the tube tail section is 3-5 mm.

[0012] Optionally, the distal end of the catheter is marked so that when the microcatheter is inserted into the proper hepatic artery, the detection device can use the mark to determine the position of the distal end of the catheter in the proper hepatic artery.

[0013] Optionally, the microcatheter is placed in a straight line within the proper hepatic artery under the guidance of a guidewire; when the guidewire is retrieved, the microcatheter returns to its original position within the proper hepatic artery.

[0014] Optionally, the injection port is adapted and fixed to the drug delivery device so that the drug is injected into the microcatheter.

[0015] The aforementioned microcatheter for hepatic artery perfusion chemotherapy utilizes a pig-tail-shaped coiled tail section with an end port and several side ports, and an injection port at the tip for drug infusion. This allows the drug to enter the microcatheter and, through the side and end ports, reach the target location in the blood vessel, thus enabling hepatic artery perfusion chemotherapy. The pig-tail-shaped coiled tail section within the proper hepatic artery, with side and end ports, ensures uniform drug release into the blood vessel, preventing laminar flow and improving the efficacy of hepatic artery perfusion chemotherapy. Furthermore, by avoiding laminar flow, the catheter can be placed more deeply into the distal portion of the proper hepatic artery, reducing the risk of dislocation. Additionally, the bending angle of the distal section conforms to the angle between the common hepatic artery and the proper hepatic artery, preventing slippage and displacement of the microcatheter within the proper hepatic artery and avoiding ectopic drug perfusion. Attached Figure Description

[0016] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on the structures shown in these drawings without creative effort.

[0017] Figure 1 A schematic diagram of the structure of a microcatheter provided for an embodiment of the utility model.

[0018] Figure 2 A schematic diagram of the distal section of a microcatheter provided in an embodiment of the utility model.

[0019] Figure 3 A schematic diagram illustrating the application scenario of the microcatheter provided in the embodiment of the utility model.

[0020] Figure 4 A schematic diagram of drug flow out through a microcatheter provided in an embodiment of the utility model.

[0021] Figure 5 This is a schematic diagram of existing microcatheter usage scenarios.

[0022] Figure 6 This is a schematic diagram illustrating laminar drug flow during existing microcatheter infusion.

[0023] Figure 7 This is a schematic diagram of the existing microcatheter detachment.

[0024] Component designations

[0025] Microcatheter - 100 Left hepatic artery - 4

[0026] Existing microcatheter - 100', right hepatic artery - 5

[0027] Distal segment-1 Gastroduodenal artery-6

[0028] Injection entrance -11 Common hepatic artery -7

[0029] Vertical segment of the gastric tube - 12 Right gastric artery - 8

[0030] Horizontal pipe section-13 Drug laminar flow-9

[0031] Pipe Tail Section-2 Preset Length-H1

[0032] End hole-21 Length of vertical pipe section-H2

[0033] Side hole - 22, curling diameter - H3

[0034] Logo-23 End hole diameter-H4

[0035] External diameter of distal segment of proper hepatic artery - 3 vessels - H5

[0036] The realization of the purpose, functional features and advantages of this utility model will be further explained in conjunction with the embodiments and with reference to the accompanying drawings. Detailed Implementation

[0037] In the description of this utility model, it should be understood that the terms "length", "width", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.

[0038] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this utility model, "a plurality of" means two or more, unless otherwise explicitly specified.

[0039] In this utility model, unless otherwise explicitly specified and limited, the terms "installation," "connection," "joining," and "fixing," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.

[0040] To provide a clearer and more accurate understanding of the present invention, a detailed description will now be provided in conjunction with the accompanying drawings. The accompanying drawings illustrate examples of embodiments of the present invention, wherein the same reference numerals denote the same elements. It is to be understood that the scale shown in the accompanying drawings is not the actual scale of the present invention, and is for illustrative purposes only, and is not a drawing based on the original dimensions.

[0041] Please refer to Figure 1This is a schematic diagram of the structure of a microcatheter for hepatic artery infusion chemotherapy provided in an embodiment of the present invention. This embodiment of the present invention provides a microcatheter 100 for hepatic artery infusion chemotherapy (HAIC). The microcatheter 100 is placed in the proper hepatic artery 3 via the common hepatic artery 7. The microcatheter 100 is made of a flexible material, such as polyetheramide polymer (PEBAX) or polyethylene. The tip of the microcatheter 100 has an injection port 11. A distal segment 1 is formed at a predetermined distance H1 from the injection port 11. The end of the distal segment 1 forms a pigtail-shaped coiled tail segment 2. The tail segment 2 and the distal segment 1 are interconnected to form a drug delivery conduit. The tail segment 2 has several side holes 22 spaced apart, and an end hole 21 is provided at the end of the tail segment 2. The microcatheter 100 is connected to a drug delivery device (not shown) via an injection port 11, allowing the drug from the delivery device to be injected into the microcatheter 100 through the injection port 11 and flow out through the end port 21 and side ports 22 into the blood vessel to reach the target location. The end port 21 is located at the center of the end port 2, which is oriented towards the inside of the tail section 2 as it curls, thus positioning the end port 21 at the center of the blood vessel, i.e., the center of the proper hepatic artery 3. Several side ports 22 disperse the drug flow into the blood vessel, preventing laminar flow. In this embodiment, the side ports 22 are evenly spaced. The preset length H1 is determined based on the target location during HAIC and configured to different lengths. Optionally, the preset length H1 is configured to be 120 cm. It is understood that in other embodiments, the spacing between each pair of side ports 22 is not the same. In addition, the microcatheter 100 is flexible, which allows it to be inserted into blood vessels in different shapes under guidance, thereby improving the convenience of inserting the microcatheter 100 into blood vessels. The specific guidance method of the microcatheter 100 will be described in detail below.

[0042] In this embodiment, the tail section 2 is curled into a pigtail shape with one or more turns, so that the end hole 21 is located in the middle of the curl. It can be understood that the tail section 2 can be curled clockwise with one or more turns, causing the end of the tail section 2 to curl inwards, thus placing the end hole 21 in the middle of the curl, or it can be curled counterclockwise with one or more turns, causing the end of the tail section 2 to curl inwards, thus placing the end hole 21 in the middle of the curl. That is to say, the curling method of the tail section 2 in this embodiment is merely an example of the curling method and number of turns of the tail section 2, and not a limitation on the curling method and number of turns of the tail section 2. Furthermore, the tail section 2 is curled in a spiral manner to place the end hole 21 in the middle of the curl, and the end hole 21 faces upwards, and several side holes 22 are also distributed in a curved pattern as the tail section 2 bends. As the drug flows out from the end port 21 and the side port 22, it is confined only within the proper hepatic artery 3. The coiled diameter H3 of the tail segment 2 is 3-5 mm.

[0043] In this embodiment, the distal segment 1 is formed by bending the microcatheter 100. The distal segment 1 includes a smooth bend away from the tail segment 2. The angle between the common hepatic artery 7 and the proper hepatic artery 3 is adapted to the bending angle of the tail segment 1, so that when the microcatheter 100 is placed in the proper hepatic artery 3, the bending angle fixes the position between the microcatheter 100 and the blood vessel in the proper hepatic artery 3. The distal segment 1 is pre-shaped as a "C", but is not limited to "C", "U", "V" or straight shapes. The microcatheter 100 is placed in the common hepatic artery 7 and the proper hepatic artery 3 with the distal segment 1 adapted to fit. When the microcatheter 100 is correctly placed in the proper hepatic artery 3, the tail segment 2 is located at the end of the proper hepatic artery 3 away from the common hepatic artery 7. The bending angle of the distal segment 1 of the microcatheter 100 conforms to the angle formed by the proper hepatic artery 3 and the common hepatic artery 7, making the distal segment 1 of the microcatheter 100 less prone to dislocation. In this embodiment, the end hole diameter H4 is smaller than the outer diameter H5 of the far section of the pipe. The end hole diameter H4 is 0.85mm-0.93mm, and the outer diameter H5 of the far section of the pipe is 0.88mm-1.00mm.

[0044] In this embodiment, the distal section 1 includes a vertical tube section 12 connected to the end of the distal section 2 away from the end hole 21, and a horizontal tube section 13 bent and connected to the vertical tube section 12. The inlet 11 is located at the head end of the horizontal tube section 13 away from the vertical tube section 12. The distal section 2 is formed by curling downwards from the end of the vertical tube section 12. The length H2 of the vertical tube section 12 is 15-25 mm. In other embodiments, the distal section 1 may also be straight overall.

[0045] In this embodiment, the microcatheter 100 is further provided with several markers 23. Specifically, several markers 23 are disposed on the distal segment 2 of the catheter so that when the microcatheter 100 is inserted into the proper hepatic artery 3, a detection device (not shown) can use the markers 23 to determine the position of the distal segment 2 in the proper hepatic artery 3. Understandably, the markers 23 can be configured as the same type or different types according to design requirements, so that the detection device can determine the position of the distal end of the microcatheter 100 based on the markers 23. In some feasible embodiments, the markers 23 can also be disposed on the inner wall of the distal segment 2 and / or the distal segment 1.

[0046] In this embodiment, when injecting medication into the patient's proper hepatic artery 3, the microcatheter 100 is first straightened using a guidewire (not shown). That is, the microcatheter 100 is placed in a straight line within the proper hepatic artery under the guidance of the guidewire, with the distal segment 2 and distal segment 1 of the catheter straightened by the guidewire. This allows the microcatheter 100 to be smoothly inserted into the blood vessel. Next, the microcatheter 100 is guided into the proper hepatic artery 3 and, with the assistance of a detection device, is guided to the appropriate position. The catheter is positioned such that the tail segment 2 is located at the end of the proper hepatic artery 3 furthest from the common hepatic artery 7, and the angle between the common hepatic artery 7 and the proper hepatic artery 3 matches the bending angle of the distal segment 1. Next, the guidewire is retrieved. When the guidewire is retrieved, the microcatheter 100 returns to its original shape within the proper hepatic artery 3, i.e., the tail segment 2 returns to a pig-tail shape, and the distal segment 1 returns to a bent shape, thus confining the microcatheter 100 within the hepatic artery. Finally, the injection port 11 is fitted and fixed to the drug delivery device to allow drug injection into the microcatheter 100. When the drug is injected into the microcatheter 100 through the injection port 11, the drug flows out from the side hole 22 and the end hole 21 and enters the target location. At this time, the tail segment 2 of the microcatheter 100 is curled into a pig-tail shape within the proper hepatic artery 3. The application scenarios of the prior art and the microcatheter provided in this application when placed in the proper hepatic artery 3 will be described in detail below with reference to the accompanying drawings.

[0047] like Figure 6 As shown, when a conventional microcatheter 100' is placed in the proper hepatic artery 3, the tip of the microcatheter 100' adheres tightly to the vessel wall (usually the right side wall). At this time, the drug infused through the microcatheter 100' adheres to the vessel wall, creating a laminar flow 9. However, because the proper hepatic artery 3 is relatively short, the drug does not have enough time to mix with the blood before entering the arterial branch on the wall side (usually the right hepatic artery 5) in the form of a laminar flow 9. And as... Figure 5 and Figure 7 As shown, when placing the microcatheter 100' in the proper hepatic artery 3, it is crucial to strictly limit the distal end of the microcatheter 100' to be located within the proper hepatic artery 3. If one or more conditions exist, such as the proper hepatic artery 3 being too short or too large, the distal end of the microcatheter 100' is prone to dislocation within the proper hepatic artery 3, causing some of the drug to flow into its proximal branch vessels, or even the distal end of the catheter to directly enter proximal branch vessels (such as the gastroduodenal artery 6, right gastric artery 8, left gastric artery, etc.). This affects the drug perfusion effect and exacerbates adverse reactions.

[0048] And such Figure 4As shown, after the microcatheter 100 is placed in the proper hepatic artery 3, when the drug flows in the proper hepatic artery 3 according to the blood flow direction shown in the diagram, the drug will flow out from the side hole 22 and the end hole 21, and flow evenly to the left hepatic artery 4 and the right hepatic artery 5 with the blood flow. Moreover, because the end hole 21 and the side hole 22 are provided on the tail section 2 of the catheter, the drug entering the proper hepatic artery 3 can be distributed more evenly in the proper hepatic artery 3, avoiding laminar flow and thus improving the effect of HAIC. In addition, because laminar flow is avoided, the microcatheter 100 can be placed more deeply in the distal end of the proper hepatic artery 3, making it less likely to dislodge. Furthermore, the bending angle of the distal section 1 of the catheter is adapted to the angle between the common hepatic artery 7 and the proper hepatic artery 3, making it less likely for the microcatheter 100 to slip or shift in the proper hepatic artery 3, avoiding ectopic drug perfusion. Therefore, the microcatheter 100 provided in this application can be used in HAIC.

[0049] In the above embodiments, by providing an end port and several side ports on the pig-tail-shaped coiled end section of the catheter, and an injection port for drug injection at the head end, the drug can enter the microcatheter and reach the target location in the blood vessel through the side ports and end port, thus enabling its application in hepatic artery perfusion chemotherapy. The pig-tail-shaped coiled end section within the proper hepatic artery, with side ports and end ports, allows for uniform drug release into the blood vessel, avoiding laminar flow and thus improving the efficacy of hepatic artery perfusion chemotherapy. Furthermore, because laminar flow is avoided, the catheter can be placed more deeply into the distal end of the proper hepatic artery, making it less prone to dislocation. Additionally, the bending angle of the distal section conforms to the angle between the common hepatic artery and the proper hepatic artery, preventing the microcatheter from slipping or shifting within the proper hepatic artery and avoiding ectopic drug perfusion.

[0050] Obviously, those skilled in the art can make various modifications and variations to this utility model without departing from the spirit and scope of this application. Therefore, if these modifications and variations of this utility model fall within the scope of the claims of this utility model and their equivalents, this utility model is also intended to include these modifications and variations.

[0051] The above-listed embodiments are merely preferred embodiments of the present utility model and should not be construed as limiting the scope of the present utility model. Therefore, any equivalent variations made in accordance with the claims of the present utility model shall still fall within the scope of the present utility model.

Claims

1. A microcatheter for hepatic artery perfusion chemotherapy, wherein the microcatheter is placed in the proper hepatic artery via the common hepatic artery, characterized in that, The microcatheter has an injection port at its tip, and a distal segment is formed at a predetermined length from the injection port. The distal segment ends in a pigtail-shaped curled tail section. The tail section has several side holes spaced apart and an end hole at its end. The end hole faces inwards from the curled tail section. When a drug is injected into the microcatheter through the injection port, the drug flows out from the side holes and the end hole and enters the target location. The distal segment of the catheter is formed by bending the microcatheter. The distal segment includes a smooth bend that is away from the distal segment. The angle between the common hepatic artery and the proper hepatic artery is adapted to the bending angle of the smooth bend. The microcatheter is placed in the common hepatic artery and the proper hepatic artery with the distal segment adapted to it, and its position with the proper hepatic artery is fixed by the bending angle.

2. The microcatheter for hepatic artery infusion chemotherapy as described in claim 1, characterized in that, The tail section of the tube is curled up in a pig tail shape, one or more times; the end hole is located in the middle of the curled tail section.

3. The microcatheter for hepatic artery perfusion chemotherapy as described in claim 2, characterized in that, When the drug flows out from the end port and side port, the drug is confined only within the proper hepatic artery.

4. The microcatheter for hepatic artery infusion chemotherapy as described in claim 3, characterized in that, The tail segment is located at the end of the proper hepatic artery away from the common hepatic artery.

5. The microcatheter for hepatic artery infusion chemotherapy as described in claim 4, characterized in that, The distal section of the tube includes a vertical tube section connected to the end of the distal section away from the end hole, and a horizontal tube section that is bent and connected to the vertical tube section. The injection port is located at the head end of the horizontal tube section away from the vertical tube section. The distal section is formed by curling downwards from the end of the vertical tube section.

6. The microcatheter for hepatic artery infusion chemotherapy as described in claim 5, characterized in that, The length of the vertical tube section is 15-25mm.

7. The microcatheter for hepatic artery infusion chemotherapy as described in claim 4, characterized in that, The diameter of the curled end of the tube is 3-5 mm.

8. The microcatheter for hepatic artery perfusion chemotherapy as described in claim 1, characterized in that, The distal end of the catheter is marked so that when the microcatheter is inserted into the proper hepatic artery, the detection device can use the mark to determine the position of the distal end of the catheter in the proper hepatic artery.

9. The microcatheter for hepatic artery infusion chemotherapy as described in claim 1, characterized in that, The microcatheter is positioned in a straight line within the proper hepatic artery under the guidance of a guidewire; when the guidewire is retrieved, the microcatheter returns to its original position within the proper hepatic artery.

10. The microcatheter for hepatic artery perfusion chemotherapy as described in any one of claims 1-9, characterized in that, The injection port is adapted and fixed to the drug delivery device so that the drug is injected into the microcatheter.

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