Visual lung rehabilitation device based on diaphragm electrical activity monitoring and electrical stimulation

Abstract

The invention relates to a visual lung rehabilitation device based on diaphragm electrical activity monitoring and electrical stimulation. The visual lung rehabilitation device comprises a phrenic nerve signal acquisition module, a septum electrical stimulation module and an electrical impedance imaging module. The phrenic nerve signal acquisition module is used for acquiring diaphragm electrical activity signals; the diaphragm electrical stimulation module processes the diaphragm electrical activity signal and then generates corresponding stimulation current and stimulation time control signals to electrically stimulate the diaphragm, so that the diaphragm is contracted / relaxed; and meanwhile, the electrical impedance imaging module monitors the pulmonary ventilation condition of the patient in the electrical stimulation treatment process, and the monitoring data of the electrical impedance imaging module is fused and integrated with the data of the diaphragm electrical activity signal again to generate a control signal of next electrical stimulation. The system has the advantages that an accurate electrical stimulation treatment management system is provided for passive lung rehabilitation treatment, the problem of man-machine confrontation in traditional electrical stimulation treatment is solved, the treatment effect can be synchronously visualized, and the competitiveness of lung rehabilitation medical equipment is enhanced.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a visualized lung rehabilitation device based on diaphragm electrical activity monitoring and electrical stimulation. Background Art

[0002] Pulmonary rehabilitation breathing training is a training method for the recovery of lung function. It helps patients with respiratory diseases recover their lung function, improve breathing efficiency and gas exchange capacity through a series of breathing training and lung function exercises. The main purpose of breathing training is to increase lung capacity, improve lung ventilation function, and enhance respiratory muscle strength and endurance. These trainings can be active training or passive treatments. Active training includes deep breathing exercises, exhalation training, cough training, respiratory muscle training, aerobic exercise, etc., which usually require patient cooperation. However, some patients are unable to cooperate with active training due to severe illness, impaired consciousness, etc. At this time, how to conduct effective passive pulmonary rehabilitation treatment is particularly important.

[0003] First of all, phrenic nerve electrical stimulation is a common traditional passive pulmonary rehabilitation treatment method. In recent years, there has also been combined electrical stimulation of the phrenic nerve and abdominal muscles. Electrodes are placed on the corresponding phrenic nerve and rectus abdominis positions on the patient's body surface, and electrical stimulation is performed using low-frequency pulses. However, this method cannot achieve synchronization with the patient's breathing, and human-machine antagonism often occurs (mainly manifested as: when the patient breathes spontaneously, the respiratory center sends instructions to the phrenic nerve, causing the diaphragm to be excited and contracted to achieve inhalation. However, if the phrenic nerve electrical stimulation is inconsistent with the diaphragm electrical signal sent by the respiratory center, the patient's inhalation action will be inconsistent with the phrenic nerve stimulation, resulting in human-machine confrontation, affecting the rehabilitation treatment effect and making the patient feel uncomfortable). In addition, with this method, we cannot visualize the improvement of lung ventilation or respiratory function, resulting in the inability to accurately evaluate the efficacy, and the satisfaction of medical staff and patients is poor.

[0004] Secondly, the existing pulmonary rehabilitation technology has not established an accurate pulmonary rehabilitation management system, nor has it established a closed-loop feedback response mechanism, which is not conducive to pulmonary rehabilitation treatment.

[0005] In summary, there is an urgent need for a pulmonary rehabilitation device that can sense the patient's ventilation needs and avoid human-machine confrontation, has visual lung function monitoring, and establishes a closed-loop feedback mechanism for electrical stimulation of the phrenic nerve. However, there is no report on such a pulmonary rehabilitation device. Summary of the invention

[0006] The purpose of the present invention is to provide a lung rehabilitation device for electrically stimulating the phrenic nerve, which can sense the patient's ventilation needs and avoid human-machine confrontation, has visual lung function monitoring and establishes a closed-loop feedback mechanism.

[0007] To achieve the above object, the technical solution adopted by the present invention is: A visualized pulmonary rehabilitation device based on diaphragm electrical activity monitoring and electrical stimulation, characterized in that the pulmonary rehabilitation device includes a phrenic nerve signal acquisition module, a diaphragm electrical stimulation module, and an electrical impedance imaging module; when the patient breathes spontaneously, the respiratory center sends a breathing command to the phrenic nerve; the phrenic nerve generates a diaphragm electrical activity signal after receiving the breathing command; the phrenic nerve signal acquisition module collects the diaphragm electrical activity signal and inputs it to the diaphragm electrical stimulation module; the diaphragm electrical stimulation module processes the diaphragm electrical activity signal and generates a corresponding stimulation current and stimulation time control signal to electrically stimulate the diaphragm, thereby causing the diaphragm to contract / relax; at the same time, the electrical impedance imaging module monitors the patient's pulmonary ventilation status during the electrical stimulation treatment, and the monitoring data of the electrical impedance imaging module is integrated with the data of the diaphragm electrical activity signal again to generate a control signal for the next electrical stimulation, so as to control the stimulation current intensity and time of the diaphragm electrical stimulation module, thereby realizing closed-loop control of diaphragm electrical stimulation; The pulmonary rehabilitation device establishes two progressive closed-loop control signals for diaphragm electrical stimulation; the first closed-loop control is: using the phrenic nerve electrical activity signal to directly generate the first electrical stimulation current / time, preliminarily controlling the diaphragm electrical stimulation module to stimulate the diaphragm, thereby establishing the first layer of closed-loop control for diaphragm electrical stimulation; the second closed-loop control is: fusing the phrenic nerve electrical activity signal after the first diaphragm electrical stimulation with the monitoring data of the electrical impedance imaging module, generating a new stimulation current / time to control the diaphragm electrical stimulation module to achieve diaphragm stimulation, thereby establishing the second layer of closed-loop control for diaphragm electrical stimulation; through the two progressive closed-loop control signals, precise control of diaphragm electrical stimulation is achieved; The phrenic nerve signal acquisition module comprises a catheter body; a detection electrode and a reference electrode are arranged at the distal end of the catheter body; a diaphragm electrical activity monitoring cable interface tube is arranged at the proximal end of the catheter body; the diaphragm electrical activity monitoring cable interface tube is externally connected to the phrenic nerve electrical activity module; the phrenic nerve electrical activity module is used to acquire and process the diaphragm electrical activity signal, the phrenic nerve electrical activity module has a built-in amplifier for amplifying the diaphragm electrical activity signal, and uses the best filtering method to exclude interference signals, and uses the double reduction method to further extract the diaphragm electrical activity signal; The diaphragm electrical stimulation module includes an identification unit, a control unit, and a stimulation unit; the identification unit is configured to receive diaphragm electrical activity signals to identify when and to what extent the patient wishes to inhale and exhale; after the identification unit sends the identification instruction to the control unit, the control unit outputs the corresponding stimulation parameter instruction; and finally the stimulation unit performs the work; The electrical impedance imaging module includes an electrode acquisition unit, an image processing unit, an image display unit, a normal image recognition unit, an abnormal image recognition unit, and a parameter correction unit; the electrode acquisition unit is used to acquire the electrical impedance signal of the body surface and transmit the electrical impedance signal to the image processing unit; the image processing unit is used to perform imaging processing on the acquired electrical impedance signal; the image display unit receives the instructions of the image processing unit and displays the image; the output end of the image display unit is provided with a normal image recognition unit and an abnormal image recognition unit; when the image display unit displays a normal image, the image recognition unit performs work, and the indicator light of the normal image recognition unit is on; when the image display unit displays an abnormal image, the abnormal image recognition unit performs work, and the indicator light of the abnormal image recognition unit is on, and the abnormal image recognition unit sends an instruction to the parameter correction unit. After receiving the instruction, the parameter correction unit extracts the data of the relevant electrical impedance signal from the image processing unit, corrects it by the parameter unit and integrates it with the data of the diaphragm electrical activity signal to generate a control signal for the next electrical stimulation.

[0008] As a preferred technical solution, the stimulation parameter instruction output by the control unit includes the intensity and time of the stimulation current.

[0009] As a preferred technical solution, the stimulation unit includes phrenic nerve electrodes and abdominal muscle nerve electrodes. The phrenic nerve electrodes include one group, including two stimulation electrodes and two reference electrodes; and the abdominal muscle electrodes include two groups.

[0010] The advantages of the present invention are: 1. The present invention is a visualized pulmonary rehabilitation device based on diaphragm electrical activity monitoring and electrical stimulation, which provides a precise passive electrical stimulation treatment for pulmonary rehabilitation respiratory management, solves the problem of human-machine confrontation in traditional electrical stimulation, and because it can visualize the treatment effect, it enhances the competitiveness of pulmonary rehabilitation medical equipment.

[0011] 2. A phrenic nerve signal acquisition module is provided, which is mainly used to obtain diaphragm electrical activity signals. Among them, diaphragm electrical activity signals are currently the best neural respiratory signals that reflect the respiratory state, because all respiratory muscles (including diaphragm and auxiliary respiratory muscles) stimulate muscle contraction by generating electrical activity. Diaphragm electrical activity is the sum of diaphragm muscle fiber action potentials induced by nerve impulses transmitted from the respiratory center to the diaphragm. When the respiratory load increases, respiratory muscle weakness, etc., leading to an increase in the respiratory center drive, the diaphragm electrical activity increases; on the contrary, when the respiratory load decreases, the diaphragm electrical activity decreases. Therefore, diaphragm electrical activity is the nerve impulse transmitted from the respiratory center to the diaphragm, which directly reflects the strength of the central drive.

[0012] 3. Through the coordination of the phrenic nerve signal acquisition module and the diaphragm electrical stimulation module, the assisted ventilation mode is adjusted by nerves, the patient's diaphragm electrical activity signal is monitored, the patient's ventilation needs (inhalation or exhalation) are sensed, and the diaphragm electrical signal is sent to the diaphragm electrical stimulation module. After receiving the signal, the diaphragm electrical stimulation module starts to output electrical stimulation, thereby achieving the patient's spontaneous breathing and human-machine synchronization. Because, in the existing technical solutions, the phrenic nerve electrical stimulation and the diaphragm electrical signal sent by the respiratory center are often inconsistent, resulting in inconsistency between the patient's inhalation action and the phrenic nerve stimulation, resulting in human-machine confrontation, affecting the rehabilitation treatment effect and making the patient feel uncomfortable.

[0013] 4. An impedance imaging module is provided to monitor the ventilation status of the lungs in real time. It dynamically presents the ventilation distribution of the lung regions through two-dimensional / three-dimensional images, thereby reflecting the heterogeneity of lung ventilation and making up for the deficiency of one-dimensional global lung monitoring of respiratory mechanics. In addition, the impedance imaging module is coordinated with the diaphragm electrical stimulation module. During the electrical stimulation process, the impedance imaging module is used to monitor the ventilation status of the lungs of the patient during electrical treatment, and the effect of the treatment is visualized. Moreover, the monitoring data of the impedance imaging module and the data of the diaphragm electrical signal are integrated to generate the control signal for the next electrical stimulation, so as to control the current intensity and time of the diaphragm electrical stimulation module. Thus, closed-loop control of diaphragm electrical stimulation is realized, the pulmonary rehabilitation treatment plan is optimized, and the pulmonary rehabilitation effect is improved.

[0014] 5. Establish two progressive closed-loop control signals for diaphragm electrical stimulation. The first closed-loop control is: it is conducive to the direct generation of the first electrical stimulation current / time by the phrenic nerve electrical activity signal, and the diaphragm electrical stimulation module is initially controlled to stimulate the diaphragm, thereby establishing the first layer of closed-loop control for diaphragm electrical stimulation; the second closed-loop control is: the phrenic nerve electrical activity signal after the first diaphragm electrical stimulation is integrated with the monitoring data of the electrical impedance imaging module to produce a new stimulation current / time to control the diaphragm electrical stimulation module to achieve diaphragm stimulation, thereby establishing the second layer of closed-loop control for diaphragm electrical stimulation. Through the two progressive closed-loop control signals, precise control of diaphragm electrical stimulation is achieved, which is conducive to improving the effect of pulmonary rehabilitation treatment.

[0015] 6. The phrenic nerve signal acquisition module and the diaphragm electrical stimulation module cooperate with each other. The control signal generated by the phrenic nerve signal acquisition module is used to synchronously and accurately control the diaphragm electrical stimulation module to perform diaphragm electrical stimulation, thereby synchronizing the diaphragm electrical stimulation process with the patient's spontaneous breathing movements, solving the human-machine confrontation problem in traditional electrical stimulation therapy. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Attached Figure 1 It is a structural block diagram of a visualized lung rehabilitation device based on diaphragm electrical activity monitoring and electrical stimulation of the present invention.

[0017] Attached Figure 2 It is a structural diagram of the phrenic nerve signal acquisition module.

[0018] Attached Figure 3 Schematic diagram of the structure of the diaphragm electrical stimulation module.

[0019] Attached Figure 4 It is the structural block diagram of the electrical impedance imaging module. DETAILED DESCRIPTION

[0020] The present invention will be further described below in conjunction with embodiments and with reference to the accompanying drawings.

[0021] The reference numerals and components involved in the drawings are as follows: 1. Respiratory center 2. Phrenic nerve 3. Diaphragm 4. Phrenic nerve signal acquisition module 5. Diaphragm electrical stimulation module 6. Electrical impedance imaging module 41. Detection electrode 42. Catheter body 43.Diaphragm electrical activity monitoring cable interface 44.Diaphragm nerve electrical activity module 51. Identification unit 52. Control unit 53. Stimulation unit 61. Electrode collection unit 62. Image processing unit 63. Image display unit 64. Image normal recognition unit 65. Image abnormal recognition unit 66. Parameter correction unit In order to make the purpose, technical solution and advantages of the embodiments of the present invention clearer, the technical solution in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0022] To facilitate understanding of the embodiments of the present invention, specific embodiments will be further explained below in conjunction with the accompanying drawings. The embodiments do not constitute a limitation on the embodiments of the present invention.

[0023] In the description of the embodiments of the present invention, it should be noted that the orientations or positional relationships indicated by the terms "first", "second", "one end", "the other end", "upper top surface", "lower bottom surface", etc. are based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention; in addition, unless otherwise clearly specified and limited, the terms "installed", "connected", and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be an indirect connection through an intermediate medium, or it can be a connection between the two elements. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances. Example 1

[0024] Please refer to Figure 1 , Figure 1 This is a structural block diagram of a visualized pulmonary rehabilitation device based on phrenic nerve 2 electrical signal monitoring and electrical stimulation of the present invention. A visualized pulmonary rehabilitation device based on phrenic nerve 2 electrical signal monitoring and electrical stimulation, the pulmonary rehabilitation device includes a phrenic nerve signal acquisition module 4, a diaphragm electrical stimulation module 5, and an electrical impedance imaging module 6; when the patient breathes spontaneously, the respiratory center 1 sends a breathing command to the phrenic nerve 2; the phrenic nerve 2 generates a diaphragm electrical activity signal after receiving the breathing command; the phrenic nerve signal acquisition module 4 collects the diaphragm electrical activity signal and inputs it to the diaphragm electrical stimulation module 5; the diaphragm electrical stimulation module 5 processes the diaphragm electrical activity signal to generate a corresponding stimulation current and stimulation time control signal to electrically stimulate the diaphragm 3, That is, the first electrical stimulation current intensity / time, so as to cause the diaphragm 3 to contract; at the same time, the electrical impedance imaging module 6 monitors the patient's lung ventilation condition after the first diaphragm electrical stimulation (using the first electrical stimulation current intensity / time), and the monitoring data of the electrical impedance imaging module 6 and the data of the diaphragm electrical activity signal collected by the diaphragm electrical stimulation module are integrated to generate a control signal for the next electrical stimulation to control the stimulation current intensity and time of the diaphragm electrical stimulation module (that is, the second and subsequent electrical stimulation current intensity / time), thereby realizing closed-loop control of diaphragm electrical stimulation, optimizing the pulmonary rehabilitation treatment plan and improving the pulmonary rehabilitation effect.

[0025] Please refer to Figure 2 , Figure 2It is a structural schematic diagram of the phrenic nerve signal acquisition module 4. The phrenic nerve signal acquisition module 4 includes a catheter body 42; the distal end of the catheter body 42 is provided with a detection electrode 41 and a reference electrode; the proximal end of the catheter body 42 is provided with a diaphragm electrical activity monitoring cable interface tube 42; the diaphragm electrical activity monitoring cable interface tube is externally connected to a phrenic nerve electrical activity module 44; the phrenic nerve electrical activity module 44 is used to acquire and process the diaphragm electrical activity signal, and the phrenic nerve electrical activity module 44 has a built-in amplifier for amplifying the diaphragm electrical activity signal, and uses the best filtering method to exclude interference signals, and uses the double reduction method to further extract the diaphragm electrical activity signal.

[0026] Please refer to Figure 3 , Figure 3 : is a schematic diagram of the structure of the diaphragm electrical stimulation module 5. The diaphragm electrical stimulation module 5 comprises an identification unit 51, a control unit 52 and a stimulation unit 53; the identification unit 51 is configured to identify when and to what extent the patient wishes to inhale and exhale based on the received diaphragm electrical activity signal; after the identification unit 51 sends the identification instruction to the control unit 52, the control unit 52 outputs the corresponding electrical stimulation parameter instruction; finally, the stimulation unit 53 performs the execution.

[0027] The electrical stimulation parameter instructions output by the control unit 52 include the intensity of the stimulation current and the stimulation time.

[0028] The stimulation unit 53 includes phrenic nerve 2 electrodes and abdominal muscle stimulation electrodes.

[0029] Please refer to Figure 4 , Figure 46 is a block diagram of the electrical impedance imaging module 6. The electrical impedance imaging module 6 includes an electrode acquisition unit 61, an image processing unit 62, an image display unit 63, an image normal recognition unit 64, an image abnormal recognition unit 65 and a parameter correction unit 66; the electrode acquisition unit 61 is used to acquire the electrical impedance signal of the body surface and transmit the electrical impedance signal to the image processing unit 62; the image processing unit 62 is used to perform imaging processing on the acquired electrical impedance signal; the image display unit 63 receives the instruction of the image processing unit 62 and displays the image; the output end of the image display unit 63 is provided with an image normal recognition unit 64 and an image abnormal recognition unit 65. Identification unit 65; when the image display unit 63 displays a normal image, the image recognition unit 51 performs work, and the indicator light of the normal image recognition unit 64 is on; when the image display unit 63 displays an abnormal image, the abnormal image recognition unit 65 performs work, and the indicator light of the abnormal image recognition unit 65 is on, and the abnormal image recognition unit 65 sends an instruction to the parameter correction unit 66. After receiving the instruction, the parameter correction unit 66 extracts the data of the relevant electrical impedance signal from the image processing unit 62, corrects it with the data of the diaphragm electrical activity signal, and generates a control signal for the next electrical stimulation.

[0030] What needs to be explained in this embodiment is: The catheter body 42 is a special stomach tube structure, which is different from a general stomach tube. The structure of the special stomach tube is designed based on comprehensive considerations of factors such as the physiological structure required for insertion into the human body and the required integrated electrodes.

[0031] A phrenic nerve signal acquisition module 4 is provided, which is mainly used to obtain the diaphragm electrical activity signal, wherein the diaphragm electrical activity signal is currently the best neural respiratory signal to reflect the respiratory state, because all respiratory muscles (including the diaphragm 3 and the auxiliary respiratory muscles) stimulate muscle contraction by generating electrical activity. The electrical activity of the diaphragm 3 is the sum of the action potentials of the diaphragm 3 muscle fibers induced by the nerve impulses transmitted from the respiratory center 1 to the diaphragm 3. When the respiratory load increases, the respiratory muscles are weak, etc., resulting in an increase in the drive of the respiratory center 1, the diaphragm electrical activity increases; on the contrary, when the respiratory load decreases, the diaphragm electrical activity decreases. Therefore, the diaphragm electrical activity is the nerve impulse transmitted from the respiratory center 1 to the diaphragm 3, which directly reflects the strength of the central drive.

[0032] Through the coordination of the phrenic nerve signal acquisition module 4 and the diaphragm electrical stimulation module 5, the assisted ventilation mode is adjusted by the nerves, the electrical activity signal of the patient's diaphragm 3 is monitored, the patient's ventilation needs (inhalation or exhalation) are sensed, and the electrical signal of the diaphragm 3 is sent to the diaphragm electrical stimulation module 5. After receiving the signal, the diaphragm electrical stimulation module 5 starts to output electrical stimulation, thereby achieving the patient's spontaneous breathing and human-machine synchronization. Because, in the existing technical solutions, the phrenic nerve electrical stimulation and the diaphragm electrical signal sent by the respiratory center are often inconsistent, resulting in inconsistency between the patient's inhalation action and the phrenic nerve stimulation, resulting in human-machine confrontation, affecting the rehabilitation treatment effect and making the patient feel uncomfortable.

[0033] An impedance imaging module 6 is provided to monitor the pulmonary ventilation status in real time. It dynamically presents the ventilation distribution of the pulmonary region through two-dimensional / three-dimensional images, thereby reflecting the heterogeneity of pulmonary ventilation and making up for the deficiency of one-dimensional global pulmonary monitoring of respiratory mechanics. In addition, the impedance imaging module 6 is matched with the diaphragm electrical stimulation module 5. During the electrical stimulation process, the impedance imaging module 6 is used to monitor the pulmonary ventilation status of the patient during the electrical treatment process, and the effect of the treatment is visualized. Moreover, the monitoring data of the impedance imaging module 6 and the data of the diaphragm 3 electrical signal are integrated to generate the control signal for the next electrical stimulation, so as to control the current intensity and time of the diaphragm electrical stimulation module 5. Thus, the closed-loop control of the diaphragm electrical stimulation is realized, the pulmonary rehabilitation treatment plan is optimized, and the pulmonary rehabilitation effect is improved.

[0034] The phrenic nerve signal acquisition module 4 includes a catheter body 42; the distal end of the catheter body 42 is provided with a detection electrode 41 and a reference electrode. The effect of this design is that it is convenient to measure the electrical signal of the diaphragm 3 in real time and accurately and exclude interference signals that are not diaphragm electrical activity. A reference electrode and a detection electrode 41 are provided, and the detection electrode 41 can be set to 10, which are linearly distributed on the catheter body 42. In this way, the position distribution of the stimulation electrode deep into the body is determined by the detection electrode 41, so that the detection electrode 41 is close to the center of electrical activity, and the diaphragm electrical activity signal of the diaphragm 3 can be obtained.

[0035] The diaphragm electrical activity monitoring cable interface 43 is externally connected to the phrenic nerve electrical activity module 44; the phrenic nerve electrical activity module 44 is used to acquire and process the diaphragm electrical activity signal, and the phrenic nerve electrical activity module 4 has a built-in amplifier for amplifying and processing the diaphragm electrical activity signal, and uses the best filtering method to eliminate interference signals, and uses the double reduction method to further extract the diaphragm electrical activity signal. The effect of this design is: it is easy to eliminate interference and successfully obtain the diaphragm electrical activity signal, because the diaphragm electrical activity signal is weak and is affected by many factors, such as the electrical activity of organs such as the heart, the movement of the electrode position, and the contraction activity of the diaphragm 3. In this implementation, the built-in amplifier of the phrenic nerve electrical activity module 44 is used to amplify the signal, and the best filtering method and the double reduction method and other measures are used to obtain the diaphragm electrical activity signal and eliminate background interference, and successfully obtain the diaphragm electrical activity signal.

[0036] Accurately obtaining the diaphragm electrical activity signal is also related to the installation position of the catheter body 42. In order to obtain the accuracy of the diaphragm electrical activity signal, the stimulation electrode must penetrate the diaphragm 3 vertically, and the position of the stimulation electrode must be confirmed through the following three steps: (1) First, measure the distance from the nose to the earlobe and the earlobe to the xiphoid process, and then calculate the depth of the gastric tube insertion according to the model of the gastric tube and the method of insertion of the gastric tube (oral or nasal). (2) Then, according to the monitored electrocardiogram (ECG) signal, continue to adjust the position of the gastric tube. Under normal circumstances, the closer to the atrium, the stronger the P wave and QRS wave signals; the closer to the stomach, the weaker the P wave and QRS wave signals. Adjust the position of the gastric tube so that the monitored P wave and QRS wave gradually weaken from strong to weak. (3) Finally, observe the downward concave position on the pressure and time curve when the diaphragm electrical activity begins to increase, and the position of the electrode can be confirmed.

[0037] The diaphragm electrical stimulation module 5 includes an identification unit 51, a control unit 52, and a stimulation unit 53. The identification unit 51 senses the specific instructions of the respiratory center 1 through the diaphragm electrical activity signal, the control unit 52 mainly senses the specific breathing instructions, and outputs the time and electrical parameters required to execute the breathing state, etc. The stimulation unit 53 is an actuator, which makes the diaphragm 3 and abdominal muscles contract / relax regularly.

[0038] The stimulation unit 53 includes 2 phrenic nerve electrodes and 2 abdominal muscle nerve electrodes. The 2 phrenic nerve electrodes are 1 group, including two stimulation electrodes and 2 reference electrodes; the abdominal muscle electrodes are 2 groups, each group including 2 stimulation electrodes. In this way, the diaphragm 3 and the abdominal muscles can be stimulated in an all-round manner, and the stimulation effect is good.

[0039] The stimulation parameter instruction output by the control unit 52 includes the intensity and time of the stimulation current. The effect of this design is: by setting instructions of different parameters, the stimulation demand can be accurately controlled, thereby meeting the patient's lung function ventilation demand.

[0040] The electrical impedance imaging module 6 is used to observe the lung ventilation status and lung function, visualize the improvement of lung ventilation or respiratory function, and at the same time has an auxiliary feedback effect on breathing, feeding back the ventilation status to the diaphragm electrical stimulation module 5, forming a closed-loop control, optimizing the lung rehabilitation treatment plan and improving the lung rehabilitation effect.

[0041] When monitoring the ventilation status, the impedance imaging module 6 can evaluate the temporal / spatial heterogeneity of lung ventilation through various means such as static images, collapse / expansion views, lung regional ventilation percentage, ventilation center (Cov), etc. When the image display is abnormal, such as when lung collapse or expansion is observed on the image, the indicator light on the abnormal image display unit lights up, and at the same time, a command is sent to the parameter correction unit 66, which then mobilizes the relevant signal of the impedance, and integrates it with the data of the diaphragm electrical activity signal to generate the control signal for the next electrical stimulation, so as to control the current intensity and time of the diaphragm electrical stimulation module 5, thereby realizing the closed-loop control of the diaphragm electrical stimulation.

[0042] The present invention provides a visualized pulmonary rehabilitation device based on phrenic nerve 2 electrical signal monitoring and electrical stimulation, which provides a precise electrical stimulation treatment management system for passive pulmonary rehabilitation treatment, solves the human-machine confrontation problem in traditional electrical stimulation treatment, and can simultaneously visualize its treatment effect, thereby enhancing the competitiveness of pulmonary rehabilitation medical equipment.

[0043] The above is only a preferred embodiment of the present invention. It should be pointed out that ordinary technicians in this technical field can make several improvements and supplements without departing from the principle of the present invention. These improvements and supplements should also be regarded as the scope of protection of the present invention.

Claims

1. A visual pulmonary rehabilitation device based on diaphragm electrical activity monitoring and electrical stimulation, characterized in that: The pulmonary rehabilitation device includes a phrenic nerve signal acquisition module, a diaphragm electrical stimulation module, and an electrical impedance imaging module; when the patient breathes spontaneously, the respiratory center sends a breathing command to the phrenic nerve; the phrenic nerve generates a diaphragm electrical activity signal after receiving the breathing command; the phrenic nerve signal acquisition module collects the diaphragm electrical activity signal and inputs it to the diaphragm electrical stimulation module; the diaphragm electrical stimulation module processes the diaphragm electrical activity signal to generate a corresponding stimulation current and stimulation time control signal to electrically stimulate the diaphragm, thereby causing the diaphragm to contract / relax; at the same time, the electrical impedance imaging module monitors the patient's pulmonary ventilation status during the electrical stimulation treatment, and the monitoring data of the electrical impedance imaging module is again integrated with the data of the diaphragm electrical activity signal collected by the diaphragm electrical stimulation module to generate a control signal for the next electrical stimulation, so as to control the stimulation current intensity and time of the diaphragm electrical stimulation module, thereby realizing closed-loop control of diaphragm electrical stimulation; The pulmonary rehabilitation device establishes two progressive closed-loop control signals for diaphragm electrical stimulation; the first closed-loop control is: using the phrenic nerve electrical activity signal to directly generate the first electrical stimulation current / time, preliminarily controlling the diaphragm electrical stimulation module to stimulate the diaphragm, thereby establishing the first layer of closed-loop control for diaphragm electrical stimulation; the second closed-loop control is: fusing the phrenic nerve electrical activity signal after the first diaphragm electrical stimulation with the monitoring data of the electrical impedance imaging module, generating a new stimulation current / time to control the diaphragm electrical stimulation module to achieve diaphragm stimulation, thereby establishing the second layer of closed-loop control for diaphragm electrical stimulation; through the two progressive closed-loop control signals, precise control of diaphragm electrical stimulation is achieved; The phrenic nerve signal acquisition module comprises a catheter body; a detection electrode and a reference electrode are arranged at the distal end of the catheter body; a diaphragm electrical activity monitoring cable interface tube is arranged at the proximal end of the catheter body; the diaphragm electrical activity monitoring cable interface tube is externally connected to the phrenic nerve electrical activity module; the phrenic nerve electrical activity module is used to acquire and process the diaphragm electrical activity signal, the phrenic nerve electrical activity module has a built-in amplifier for amplifying the diaphragm electrical activity signal, and uses the best filtering method to exclude interference signals, and uses the double reduction method to further extract the diaphragm electrical activity signal; The diaphragm electrical stimulation module comprises an identification unit, a control unit and a stimulation unit; the identification unit is configured to identify when and to what extent the patient wishes to inhale and exhale according to the received diaphragm electrical activity signal; after the identification unit sends the identification instruction to the control unit, the control unit outputs the corresponding stimulation parameter instruction; finally, the stimulation unit performs the work; The phrenic nerve signal acquisition module cooperates with the diaphragm electrical stimulation module, and uses the control signal generated by the phrenic nerve signal acquisition module to synchronously and accurately control the diaphragm electrical stimulation module to perform diaphragm electrical stimulation, thereby synchronizing the diaphragm electrical stimulation process with the patient's spontaneous breathing movements; The electrical impedance imaging module includes an electrode acquisition unit, an image processing unit, an image display unit, a normal image recognition unit, an abnormal image recognition unit and a parameter correction unit; the electrode acquisition unit is used to acquire the electrical impedance signal of the body surface and transmit the electrical impedance signal to the image processing unit; the image processing unit is used to perform imaging processing on the acquired electrical impedance signal; the image display unit receives the instruction of the image processing unit and displays the image; the output end of the image display unit is provided with a normal image recognition unit and an abnormal image recognition unit; when the image display unit displays a normal image, the image recognition unit performs work, and the indicator light of the normal image recognition unit is on; when the image display unit displays an abnormal image, the abnormal image recognition unit performs work, and the indicator light of the abnormal image recognition unit is on; the abnormal image recognition unit sends an instruction to the parameter correction unit, and when the parameter correction unit receives the instruction, it extracts the data of the relevant electrical impedance signal from the image processing unit, corrects it by the parameter unit and integrates it with the data of the diaphragm electrical activity signal to generate a control signal for the next electrical stimulation.

2. The visualized pulmonary rehabilitation device according to claim 1, characterized in that: The stimulation parameter instruction output by the control unit includes the intensity and time of the stimulation current.

3. The visualized pulmonary rehabilitation device according to claim 1, characterized in that: The stimulation unit comprises phrenic nerve electrodes and abdominal muscle nerve electrodes. The phrenic nerve electrodes comprise one group, including two stimulation electrodes and two reference electrodes; and the abdominal muscle electrodes comprise two groups.

Images