Traditional Chinese medicine composition and application thereof

Abstract

The invention discloses a traditional Chinese medicine composition, which is prepared from the following raw material components in parts by weight: 10 to 40 parts of rhizoma curcumae longae, 10 to 30 parts of radix et rhizoma rhei, 20 to 45 parts of ramulus cinnamomi, 20 to 45 parts of fried ramulus mori, 15 to 45 parts of radix puerariae, 10 to 45 parts of lignum sappan, 15 to 45 parts of herba lycopodii, 10 to 45 parts of rhizoma chuanxiong and 10 to 45 parts of radix cyathulae. The traditional Chinese medicine composition provided by the invention has obvious advantages in chronic muscle and bone disease treatment theory and practice, is reliable in curative effect, small in toxic and side effects and relatively low in cost, particularly pays attention to overall regulation of human body functions, stimulates the disease resistance and rehabilitation ability of human bodies, and is beneficial to treatment of chronic muscle and bone diseases with complex etiology and reduction of recurrence rate.

Description

Technical Field

[0001] The present invention relates to the field of Chinese medicine formula, and in particular to a Chinese medicine composition and its application. Background Art

[0002] Chronic bone and muscle diseases are caused by the natural degeneration of the human body, which is accelerated by trauma, strain, exposure to external pathogens, metabolic disorders and other factors. It causes imbalance in the dynamic and static forces of bones and muscles in the spine, bones and joints, skeletal muscles and other parts, and presents a syndrome of symptoms and signs such as systemic and local pain, swelling, numbness, muscle atrophy, and limited mobility.

[0003] Based on the perspective of big health, the research scope of chronic bone and muscle diseases can be summarized into the following categories: ① Degenerative diseases of the spine: such as cervical spondylosis, lumbar spondylosis (lumbar disc herniation, lumbar spinal stenosis), etc. ② Degenerative diseases of bones and joints: such as hip / knee osteoarthritis, etc. ③ Soft tissue diseases: such as frozen shoulder, rotator cuff injury, meniscus injury, lateral epicondylitis, myofasciitis, etc. ④ Bone metabolic diseases: such as osteoporosis, etc.

[0004] my country has entered an aging society since 1999. In 2020, the population over 60 years old will be about 264 million, and it is expected to reach 483 million in 2050. The current incidence of osteoarthritis alone will affect hundreds of millions of people. Most of these diseases have an insidious onset and complex pathogenic factors, which impose a heavy economic burden on individuals, families, society and the country. Its clinical features are "one big, five many, and five high", namely, it is highly harmful; there are many patients, many causes, many types of diseases, many complications, and many treatments; the incidence rate, disability rate, recurrence rate, surgery rate, and medical expenses are high. Therefore, it has become a major medical task and research direction for orthopedic medical workers to carry out in-depth basic and clinical research.

[0005] The significant advantage of Western medicine in treating chronic bone and muscle diseases is that it works quickly. For example, during the acute attack period, painkillers and anti-inflammatory drugs are used, such as non-steroidal anti-inflammatory drugs (NSAIDs): ibuprofen, diclofenac, aceclofenac, etc.; selective COX-2 inhibitors: celecoxib, etoricoxib; glucocorticoids: prednisone, dexamethasone, etc. These drugs can quickly relieve pain and inflammatory symptoms and improve the quality of life of patients. However, long-term use of drugs may cause side effects such as gastrointestinal reactions and liver and kidney damage. In addition, Western medicine treatment is also prone to relapse. For some chronic diseases, simple Western medicine treatment may only relieve symptoms, but cannot fundamentally solve the cause, resulting in easy recurrence of the disease.

[0006] Traditional Chinese medicine classifies chronic myositis as "muscle paralysis" and "bone paralysis". In view of the long course of chronic myositis and damage to multiple tissues and organs, traditional Chinese medicine can better play the advantages of "overall regulation, local precision, and comprehensive intervention", and is more suitable for the middle-aged and elderly people with impaired visceral function, poor metabolic function, and chronic myositis. Traditional Chinese medicine treatment of chronic myositis is guided by traditional Chinese medicine theory, and under the guidance of the principles of holistic treatment and taking both the symptoms and the root causes into consideration, it adopts the treatment principle of traditional Chinese medicine's characteristic internal and external treatment, and the effect is remarkable.

[0007] Treating different diseases with the same method is a significant feature of TCM treatment. Its connotation means that different diseases can be treated with the same method if the pathogenesis is the same. The same pathogenesis is the basis for treating different diseases with the same method, and the combination of disease and syndrome is the key to treating different diseases with the same method. From the perspective of Western medicine, chronic myositis belongs to different parts of the body such as the neck, shoulders, waist and legs, and the clinical symptoms are also different. The causes are diverse, but the pathogenesis of TCM is basically the same. Its essence can be summarized as the invasion of wind, cold and dampness, which leads to the disorder of qi and blood. Therefore, clinical treatment can be based on "bi" and "treating different diseases with the same method". The core treatment method is to dispel wind, cold and dampness, regulate qi and remove blood stasis.

[0008] Wu Shiji of the Qing Dynasty mentioned in Lihua Pianwen: "The principle of external treatment is the principle of internal treatment; the medicine for external treatment is also the medicine for internal treatment. The only difference is the method. The medical theory and medicine properties are the same, but the method is magical and changeable." This statement clarifies the similarities between external treatment and internal treatment in Chinese medicine in terms of medical theory and medicine properties, but the treatment methods are different. "Wuerbing Fang" records a variety of external treatment methods, such as plastering, fumigation, etc., which provides an early practical basis for the development of external treatment methods in Chinese medicine. Therefore, it is a beneficial exploration to study a Chinese medicine composition, a compound decoction combined with Chinese medicine soaking, wet compress, fumigation and other Chinese medicine characteristic external treatment methods for the treatment of chronic bone and muscle diseases. Summary of the invention

[0009] In view of the shortcomings of the existing drugs mentioned above, this application, based on the inheritance of the Shi family traumatology school's academic ideas of "focusing on Qi and blood first" and "treating both evil and evil, especially phlegm and dampness", summarizes many years of clinical medication and treatment experience, and based on the team's scientific research exploration, created the Huangzhi Tongbi Recipe, which consists of 9 medicines.

[0010] The present application provides a traditional Chinese medicine composition, which comprises the following raw material components by weight: 10-40 parts of turmeric, 10-30 parts of rhubarb, 20-45 parts of cinnamon twig, 20-45 parts of stir-fried mulberry twig, 15-45 parts of kudzu root, 10-45 parts of sappan wood, 15-45 parts of lycopodii herba, 10-45 parts of ligusticum chuanxiong, and 10-45 parts of cyathula capitata.

[0011] The present application also provides a Chinese medicine preparation, which is prepared using the above-mentioned Chinese medicine composition as raw material.

[0012] The present application also provides the use of the above-mentioned Chinese medicine composition or the above-mentioned Chinese medicine preparation in the preparation of drugs for preventing and / or treating chronic bone and muscle diseases.

[0013] The beneficial effects brought by the present application include but are not limited to: (1) The Chinese medicine compound created by the present application has the effects of promoting blood circulation and removing blood stasis, regulating qi and unblocking collaterals, and taking into account the effects of dispelling wind and dampness. It has a wide range of clinical indications, especially in the treatment of qi stagnation and blood stasis syndrome and wind-cold arthralgia in chronic musculoskeletal diseases. (2) Strong local targeting: directly acting on the lesion site, it can exert the efficacy of the drug more concentratedly and improve the therapeutic effect. (3) Reduce systemic side effects: Since it is a local external application, the amount of drug absorbed into the blood circulation is relatively small, thereby reducing the risk of systemic side effects. (4) Good compatibility with other treatment methods: It can be used in combination with other topical drugs (such as ointments) or oral drugs to enhance the therapeutic effect. (5) Economical and easy to use: Compared with some other treatment methods, lotions are usually cheaper and more easily accepted by patients. At the same time, it is easy to make and clean, and patients can operate it at home by themselves without the need for special medical equipment or professional assistance. In conclusion, external preparations for the limbs have many advantages in treating qi stagnation and blood stasis and wind-cold arthralgia in chronic myositis related to the limbs and spine, providing patients with a convenient, effective and relatively safe treatment option. In summary, TCM treatment has obvious advantages in the theory and practice of treating chronic myositis, with reliable efficacy, few toxic and side effects, and relatively low cost. In particular, it focuses on the overall regulation of human functions, stimulates the body's disease resistance and rehabilitation ability, and is conducive to the treatment of chronic myositis with complex etiology and reduces the recurrence rate. BRIEF DESCRIPTION OF THE DRAWINGS

[0014] The present application will be further described in the form of exemplary embodiments, which will be described in detail with reference to the accompanying drawings. These embodiments are not restrictive, and include:

[0015] Figure 1 The degree of pain is determined according to the VAS pain scoring standard shown in some embodiments of the present application.

[0016] Figure 2 This is a comparison of the effectiveness of the control group and the treatment group shown in some embodiments of the present application. DETAILED DESCRIPTION

[0017] In order to more clearly illustrate the technical solutions of the embodiments of this specification, the following is a brief introduction to the drawings required for the description of the embodiments. Obviously, the drawings described below are only some examples or embodiments of this specification. For ordinary technicians in this field, this specification can also be applied to other similar scenarios based on these drawings without creative work. Unless it is obvious from the language environment or otherwise explained, the same reference numerals in the figures represent the same structure or operation.

[0018] As shown in this specification and claims, unless the context clearly indicates an exception, the words "a", "an", "an" and / or "the" do not refer to the singular and may also include the plural. Generally speaking, the terms "comprise" and "include" only indicate the inclusion of the steps and elements that have been clearly identified, and these steps and elements do not constitute an exclusive list. The method or device may also include other steps or elements.

[0019] Flowcharts are used in this specification to illustrate the operations performed by the system according to the embodiments of this specification. It should be understood that the preceding or following operations are not necessarily performed precisely in order. Instead, the steps may be processed in reverse order or simultaneously. At the same time, other operations may also be added to these processes, or one or more operations may be removed from these processes.

[0020] The present application provides a traditional Chinese medicine composition, which comprises the following raw material components by weight: 10-40 parts of turmeric, 10-30 parts of rhubarb, 20-45 parts of cinnamon twig, 20-45 parts of stir-fried mulberry twig, 15-45 parts of kudzu root, 10-45 parts of sappan wood, 15-45 parts of lycopodii herba, 10-45 parts of ligusticum chuanxiong, and 10-45 parts of cyathula capitata.

[0021] In some embodiments, the Chinese medicine composition comprises the following raw material components by weight:

[0022] 10-40 parts of turmeric, for example, 12-38 parts, 14-36 parts, 16-34 parts, 18-32 parts, 20-30 parts, 22-28 parts, 24-26 parts;

[0023] 10-30 parts of rhubarb, for example 12-28 parts, 14-26 parts, 16-24 parts, 18-22 parts, 20-22 parts;

[0024] 20-45 parts of cassia twig, for example, 22-43 parts, 24-41 parts, 26-39 parts, 28-37 parts, 30-35 parts, 32-33 parts;

[0025] 20-45 parts of stir-fried mulberry branches, such as 22-43 parts, 24-41 parts, 26-39 parts, 28-37 parts, 30-35 parts, 32-33 parts;

[0026] 15-45 parts of Pueraria root, for example, 17-43 parts, 19-41 parts, 21-39 parts, 23-37 parts, 25-35 parts, 27-33 parts, 29-31 parts;

[0027] 10-45 parts of Sappan wood, for example, 12-43 parts, 14-41 parts, 16-39 parts, 18-37 parts, 20-35 parts, 22-33 parts, 24-31 parts, 26-29 parts, 28-29 parts;

[0028] 15-45 parts of Lycopodiella ciliata, for example, 17-43 parts, 19-41 parts, 21-39 parts, 23-37 parts, 25-35 parts, 27-33 parts, 29-31 parts;

[0029] 10-45 parts of Ligusticum chuanxiong, for example 12-43 parts, 14-41 parts, 16-39 parts, 18-37 parts, 20-35 parts, 22-33 parts, 24-31 parts, 26-29 parts, 28-29 parts;

[0030] 10-45 parts of Cyathula capitata, for example 12-43 parts, 14-41 parts, 16-39 parts, 18-37 parts, 20-35 parts, 22-33 parts, 24-31 parts, 26-29 parts, 28-29 parts.

[0031] In some embodiments, preferably, the Chinese medicine composition includes the following raw material components: 10-30 parts of turmeric, 10-20 parts of rhubarb, 20-30 parts of cinnamon twig, 20-30 parts of stir-fried mulberry twig, 15-30 parts of kudzu root, 10-30 parts of rhubarb, 15-30 parts of lycopodii, 10-30 parts of ligusticum wallichii, 10-30 parts of chuanxiong, and 10-30 parts of cyathula capitata.

[0032] In some embodiments, more preferably, the Chinese medicine composition includes the following raw material components: 10 parts of turmeric, 10 parts of rhubarb, 20 parts of cinnamon twig, 20 parts of stir-fried mulberry twig, 15 parts of kudzu root, 10 parts of rhubarb, 15 parts of lycopodii herba, 10 parts of ligusticum chuanxiong, and 10 parts of cyathula capitata.

[0033] The nature, flavor, meridians, efficacy and composition analysis of each drug in the formula:

[0034] Turmeric (Curcuma longa L.): Nature and flavor: pungent, bitter, warm. Meridians: spleen and liver meridians. Efficacy: promotes blood circulation and qi circulation, relieves pain. It is commonly used for various symptoms caused by blood stasis and qi stagnation, such as chest and flank pain, waist and back pain, and pain and numbness in the shoulders and arms caused by rheumatic arthralgia.

[0035] Rhubarb (R.officinale Baill.) Nature and flavor: bitter, cold. Meridians: spleen, stomach, large intestine, liver, pericardium. Efficacy: purgative, removing stagnation, removing blood stasis and promoting menstruation. Taking it after can enhance its purgative and removing blood stasis effects. It is often used for patients with acute muscle and bone pain caused by internal blood stasis and pain caused by obstruction. Rhubarb can play a special role in removing blood stasis.

[0036] Cinnamomum cassia Presl: Nature and flavor: pungent, sweet, warm. Meridians: heart, lung, bladder. Efficacy: sweating, relieving muscles, warming and unblocking meridians. Commonly used for joint pain caused by wind-cold invading the exterior, cinnamon can warm the meridians and unblock the collaterals, assist yang and transform qi, and promote diuresis and reduce swelling.

[0037] Stir-fried Morus alba L: Nature and flavor: slightly bitter, neutral. Meridian: liver meridian. Efficacy: dispel rheumatism and benefit joints. Commonly used for joint pain, numbness, flexion and extension difficulties caused by rheumatism, especially in the upper limb shoulder and arm joints.

[0038] Pueraria lobata: Nature and flavor: sweet, pungent, cool. Meridians: spleen and stomach meridians. Efficacy: relieves muscle spasms, promotes blood circulation. Commonly used in the treatment of cervical spondylosis: It has a certain effect on relieving neck pain and stiffness caused by blocked meridians and poor blood circulation.

[0039] Biancaea sappan (L.) Tod.: Nature and flavor: sweet, salty, pungent, neutral. Meridians: heart, liver, spleen. Efficacy: promoting blood circulation, removing blood stasis, reducing swelling and relieving pain. It is often used to relieve local blood stasis, swelling and pain after trauma. Biancaea sappan can accelerate the dissipation of blood stasis and reduce swelling and pain.

[0040] Common clubmoss herb Latin: Nature and flavor: slightly bitter, pungent, warm. Meridians: liver, spleen, kidney. Efficacy: dispel wind and dampness, relax muscles and activate collaterals. Indications include: joint pain, flexion and extension difficulties, muscle soreness and other symptoms caused by rheumatism; limb numbness caused by wind and dampness blocking the meridians; and a certain effect on relieving tendon and vein damage, swelling and pain after trauma.

[0041] Ligusticum sinense'Chuanxiong': Nature and flavor: pungent, warm. Meridians: liver, gallbladder, pericardium. Efficacy: promoting blood circulation and qi, dispelling wind and relieving pain. It is a "blood qi medicine". It is often used for diseases caused by qi and blood stasis, can promote blood circulation, dissipate blood stasis, and promote qi circulation, relieve qi stagnation and blood stasis; rheumatic arthralgia caused by rheumatic arthralgia blocking the meridians, can improve symptoms such as joint pain and numbness.

[0042] Cyathula officinalis Kuan: Nature and flavor: sweet, slightly bitter, neutral. Meridians: liver and kidney meridians. Efficacy: removes blood stasis and dredges meridians, and unblocks joints. "Leading blood downward": guiding blood downward, often used for tendon and vein pain caused by blood stasis, can remove blood stasis, dredge meridians, unblock joints, help improve joint mobility, and relieve joint pain, flexion and extension difficulties and other symptoms.

[0043] Formula analysis:

[0044] In the formula, turmeric and rhubarb are the main drugs, which are mainly used to promote blood circulation, remove blood stasis, dredge meridians and relieve pain, with the main effect of solving blood stasis. Cinnamon twig and stir-fried mulberry twig are the assistant drugs, which dispel cold, warm and dredge meridians, dispel wind, relax muscles and dredge meridians, especially to improve the symptoms of upper limb shoulder and arm joints. Pueraria root, spatholobi and Su wood can dispel rheumatism, benefit joints, promote diuresis and reduce swelling, and relieve symptoms such as rheumatic bone pain, back pain and poor joint movement. Chuanxiong is a blood-qi drug, and Sichuan Cyathula is a classic meridian-guiding drug, which guides blood downward. Both of them promote qi and blood circulation, and are both guiding drugs. The whole formula is compatible, and they work together to promote blood circulation, remove blood stasis, dispel wind and dampness, dredge meridians and relieve pain.

[0045] Medication characteristics and main effects:

[0046] Features: It gives equal emphasis to promoting blood circulation and removing blood stasis, regulating qi and unblocking collaterals, and also takes into account the dispelling of wind and dampness.

[0047] Efficacy: It has the effects of promoting blood circulation and removing blood stasis, dispelling wind and dampness, unblocking meridians and relieving pain. It is suitable for joint pain, limb numbness, and flexion and extension difficulties caused by rheumatism and blood stasis.

[0048] The present application also provides a Chinese medicine preparation, which is prepared using the above-mentioned Chinese medicine composition as raw material.

[0049] In some embodiments, the above-mentioned traditional Chinese medicine composition can be decocted with water and filtered to obtain the traditional Chinese medicine preparation.

[0050] In some embodiments, the traditional Chinese medicine preparation may include a traditional Chinese medicine decoction and / or coarse granular medicinal residues.

[0051] In some embodiments, before decoction, the Chinese medicine composition can be soaked in water for 30 minutes to 1 hour;

[0052] In some embodiments, rhubarb can be added later during the decocting process.

[0053] The present application also provides the use of the above-mentioned Chinese medicine composition or the above-mentioned Chinese medicine preparation in the preparation of drugs for preventing and / or treating chronic bone and muscle diseases.

[0054] The term "prevention and / or treatment" (and grammatical variations thereof) refers to an attempt to alter the natural course of a disease in a treated individual, and may be a clinical intervention performed for prevention or during the course of clinical pathology. Desired effects of treatment include, but are not limited to, preventing the occurrence or recurrence of the disease, alleviating symptoms, reducing any direct or indirect pathological consequences of the disease, preventing metastasis, slowing the rate of disease progression, ameliorating or alleviating the disease state, and eliminating or improving prognosis.

[0055] In some embodiments, the chronic bone and muscle diseases may include degenerative spinal diseases, degenerative bone and joint diseases, soft tissue diseases or bone metabolic diseases.

[0056] In some embodiments, the spinal degenerative disease may include cervical spondylosis and lumbar spondylosis.

[0057] In some embodiments, the degenerative bone joint disease may include hip / knee osteoarthritis.

[0058] In some embodiments, the soft tissue disease may include frozen shoulder, rotator cuff injury, meniscus injury, lateral epicondylitis or myofasciitis.

[0059] In some embodiments, the metabolic bone disorder may include osteoporosis.

[0060] In some embodiments, the drug can reduce serum pain mediator levels. In some embodiments, preferably, the drug can reduce serum prostaglandin E2, substance P, serotonin or interleukin-1β levels.

[0061] In some embodiments, the chronic musculoskeletal disease may include at least one of cervical disc herniation, cervical osteoarthritis, lumbar disc herniation, lumbar osteoarthritis, periarthritis of the shoulder, knee osteoarthritis or plantar fasciitis.

[0062] In some embodiments, the Chinese medicine composition, Chinese medicine preparation or medicine can be an external medicine.

[0063] Examples of applicable symptoms:

[0064] Cervical spondylosis (neck pain): Applicable to cervical spondylosis of qi stagnation and blood stasis type caused by trauma or strain. For example, long-term poor posture causes neck strain, resulting in muscle pain, arm numbness, and difficulty in movement; cervical spondylosis caused by rheumatism and arthralgia, symptoms include stiff neck, shoulder and back pain, etc.

[0065] Periarthritis of shoulder (shoulder arthralgia): It is suitable for periarthritis of shoulder caused by wind, cold and dampness, qi stagnation and blood stasis, which is manifested as shoulder pain, heaviness, limited movement, and aggravated by cold. For example, the elderly and weak, who are invaded by wind, cold and dampness, and whose shoulder meridians are blocked by qi and blood, will experience shoulder pain, stiffness, adhesion, and difficulty in lifting.

[0066] Lumbar pain (lumbar paralysis): Suitable for lumbago caused by meridian stasis, with symptoms of soreness, stiffness, difficulty in flexion and extension, and even limited movement. Lumbar pain caused by cold and dampness blocking the meridians, with symptoms including cold pain, heaviness, difficulty in turning, and worsening in cold weather.

[0067] Arthritis (bone arthritis): Applicable to rheumatoid arthritis, symptoms include joint pain, stiffness, deformity, and difficulty in movement, which are aggravated by cold or rainy days; osteoarthritis, symptoms include joint pain, swelling, difficulty in flexion and extension, bone hyperplasia, which are aggravated by fatigue.

[0068] Heel pain (tendon arthritis): also known as plantar fasciitis, heel pain caused by cold, dampness and blood stasis in the meridians. Symptoms include cold and painful heels, which are aggravated by cold and relieved by heat. The heel pain caused by blood stasis in the meridians is like a thorn, and the pain is localized. It is usually most obvious in the first step after getting up in the morning. The pain is aggravated after standing or walking for a long time and can be relieved after rest.

[0069] The present application also provides a method for treating chronic bone and muscle diseases, which comprises administering an effective amount of the Chinese medicine preparation of the present application to a subject in need thereof.

[0070] The experimental methods in the following examples are conventional methods unless otherwise specified. The experimental materials used in the following examples are purchased from conventional biochemical reagent companies unless otherwise specified. The quantitative tests in the following examples are repeated three times, and the results are averaged.

[0071] Example 1

[0072] Chinese medicine composition 1#: 10g of turmeric, 10g of rhubarb (added later), 20g of cinnamon twig, 20g of stir-fried mulberry twig, 15g of kudzu root, 10g of sappan wood, 15g of lycopodiella cuneata, 10g of ligusticum chuanxiong, 10g of cyathula capitata

[0073] Chinese medicine composition 2#: 20g of turmeric, 20g of rhubarb (added later), 40g of cinnamon twig, 40g of stir-fried mulberry twig, 30g of kudzu root, 30g of sappan wood, 45g of lycopodiella cuneata, 30g of chuanxiong, 30g of chuanxiong

[0074] Chinese medicine composition 3#: 40g of turmeric, 30g of rhubarb (added later), 45g of cinnamon twig, 45g of stir-fried mulberry twig, 45g of kudzu root, 45g of sappan wood, 45g of spatholobi, 45g of lycopodiella cuneata, 45g of ligusticum chuanxiong, 45g of cyathula capitata

[0075] Chinese medicine composition 4#: 30g of turmeric, 20g of rhubarb (added later), 30g of cinnamon twig, 30g of stir-fried mulberry twig, 30g of kudzu root, 20g of sappan wood, 30g of spatholobi, 30g of ligusticum wallichii, 30g of chuanxiong, 30g of chuanxiong

[0076] Chinese medicine composition 5#: 40g of turmeric, 20g of rhubarb (added later), 30g of cinnamon twig, 30g of stir-fried mulberry twig, 30g of kudzu root, 40g of sappan wood, 45g of schizonepeta tenuifolia, 30g of chuanxiong, 35g of chuanxiong

[0077] Decoction steps:

[0078] Cleaning medicinal materials: Rinse the external Chinese medicine with clean water to remove dust and impurities on the surface.

[0079] Soaking herbs: Place the herbs in a decoction vessel and add an appropriate amount of cold water. The water level should generally be 2-3 cm higher than the herbs. Soak for about 30 minutes to 1 hour to allow the herbs to fully absorb water, which is conducive to the decoction of effective ingredients.

[0080] Decoction process: first boil the liquid medicine over high heat, then turn to low heat and keep it at a slight boil. This usually takes 10-15 minutes. Rhubarb should be added 5-10 minutes before the liquid medicine is ready.

[0081] Number of decoctions: Usually, the medicine is decocted twice to fully extract the effective ingredients. When decocting the medicine for the second time, the amount of water (the amount of water added is 2 / 3 of the amount of water used in the first decoction) and the decoction time (usually 5-10 minutes) can be appropriately reduced.

[0082] The medicinal materials in the Chinese medicine formula are all rhizomes or branches of plants except for the herb spatholobi which is in grass form. They are coarse particles after processing and can be decocted with water to obtain the Chinese medicine decoction and coarse granular medicinal residues.

[0083] Correspondingly, we obtain Chinese herbal decoction 1#, Chinese herbal decoction 2#, Chinese herbal decoction 3#, Chinese herbal decoction 4#, and Chinese herbal decoction 5#.

[0084] Directions:

[0085] Decoctions can be used in combination with stain removal and fumigation treatments, and coarse granular medicinal residues can be used in combination with wet hot compresses and ironing treatments.

[0086] Example 2

[0087] A total of 600 patients with chronic bone and muscle diseases who visited our hospital from January 2022 to March 2024 were selected as research subjects and divided into 10 groups according to the random number table method, including control group 1, control group 2, control group 3, control group 4, control group 5 and treatment group 1, treatment group 2, treatment group 3, treatment group 4 and treatment group 5, with 60 cases in each group.

[0088] Diagnostic criteria:

[0089] Western medicine diagnostic criteria: in line with the diagnostic criteria for cervical spondylosis, lumbar disc herniation, frozen shoulder, knee osteoarthritis, and plantar fasciitis in Practical Orthopedics. In line with the diagnostic criteria of "Expert Consensus on Classification, Diagnosis and Non-surgical Treatment of Cervical Spondylosis (2018)", "Chinese Medical Association Orthopedic Branch Orthopedic Rehabilitation Group·Guidelines for Diagnosis and Treatment of Lumbar Disc Herniation (2020)", "World Federation of Chinese Medicine Societies·Expert Consensus on Integrated Chinese and Western Medicine Diagnosis and Treatment of Frozen Shoulder (2023)", "World Federation of Chinese Medicine Societies·Expert Consensus on Integrated Chinese and Western Medicine Diagnosis and Treatment of Knee Osteoarthritis (2023)", "American Physical Therapy Association Orthopedic Branch·Guidelines for Diagnosis and Treatment of Heel Pain-Plantar Fasciitis (2023)".

[0090] TCM diagnostic standards: refer to the TCM industry standards of the People's Republic of China (ZY / T001.1-94) ① "TCM disease diagnosis and efficacy standards · TCM orthopedics disease · cervical spondylosis" ② "TCM disease diagnosis and efficacy standards · TCM orthopedics disease · lumbar disc herniation" ③ "TCM disease diagnosis and efficacy standards · TCM orthopedics disease · frozen shoulder" ④ "TCM disease diagnosis and efficacy standards · TCM orthopedics disease · bone arthritis" ⑤ "TCM disease diagnosis and efficacy standards · TCM orthopedics disease · myofasciitis" TCM syndrome differentiation: according to the "National Standard of the People's Republic of China on Clinical Diagnosis and Treatment Terminology of Traditional Chinese Medicine Syndrome Part" (GB / T16751.1-1997) ① Syndrome of qi stagnation and blood stasis: Qi stagnation, poor blood circulation, blood stasis and blockage are characterized by distension, stuffiness, pain, occasional tingling, or lumps, scattered and gathered from time to time, purple or spotted tongue, and stringy and astringent pulse as common symptoms. ②Syndrome of cold-dampness obstruction and stagnation: Cold-dampness evil invades and blocks the Qi, with common symptoms such as heaviness of the head and body, joint pain, difficulty in flexion and extension, no sweating, or swelling of the face and limbs, loose stools, difficulty urinating, white and moist tongue coating, and moist or slippery pulse. The diagnosis can be confirmed by combining the above two main symptoms or two secondary symptoms and referring to the tongue and pulse.

[0091] Inclusion criteria: ① meet the diagnostic criteria of traditional Chinese and Western medicine; ② age between 18 and 75 years old; ③ complete informed consent.

[0092] Exclusion criteria: ① not meeting the diagnostic criteria; ② under 18 years old or over 75 years old; ③ having primary diseases such as cardiovascular and cerebrovascular diseases; ④ special populations (mental illness, pregnant women); ⑤ fractures, tumors and other diseases; ⑥ indications for surgery.

[0093] Exclusion criteria: ① loss to follow-up or dropout; ② self-administration of other drugs or therapies during treatment; ③ patients unable to continue treatment due to other factors.

[0094] method:

[0095] Control group: Control group 1-5, each group of 60 patients were uniformly given Gutongling tincture (commercial external Chinese patent medicine dosage form). This medicine is a typical representative of external blood circulation and collateral activating agents, which has the effects of warming the meridians and dispelling cold, dispelling wind and activating blood circulation, and relieving pain. It is mainly used for lumbar and cervical vertebrae hyperosteogeny, osteoarthritis, scapulohumeral periarthritis, and rheumatoid arthritis. Usage: For external use, once a day, use according to the instructions for two weeks as a course of treatment.

[0096] Treatment Group:

[0097] Treatment group 1 (neck arthralgia group) was given the Chinese medicine decoction 1# of Example 1 of the present invention for external use, 7 doses / week, and continuous treatment for 2 weeks. Treatment group 2 (lumbar arthralgia group) was given the Chinese medicine decoction 2# of Example 1 of the present invention for external use, 7 doses / week, and continuous treatment for 2 weeks. Treatment group 3 (shoulder arthralgia group) was given the Chinese medicine decoction 3# of Example 1 of the present invention for external use, 7 doses / week, and continuous treatment for 2 weeks. Treatment group 4 (knee arthralgia group) was given the Chinese medicine decoction 4# of Example 1 of the present invention for external use, 7 doses / week, and continuous treatment for 2 weeks. Treatment group 5 (tendon arthralgia group) was given the Chinese medicine decoction 5# of Example 1 of the present invention for external use, 7 doses / week, and continuous treatment for 2 weeks.

[0098] Efficacy evaluation method:

[0099] 1. Pain score: All 10 groups of patients were assessed for pain using the visual analogue scale (VAS) before treatment and two weeks after treatment.

[0100] Description: The VAS method is widely used in clinical pain assessment in China. The basic method is: use a 10-cm long floating ruler with 10 scales on one side, with "0" and "10" at the two ends. 0 points means no pain, and 10 points means the most severe pain that is unbearable.

[0101] The VAS pain scoring system defines the degree of pain as follows (see Figure 1 ):

[0102] ①0 points: The patient does not feel any pain.

[0103] ② Below 3 points: The patient has slight pain but can still bear it.

[0104] ③4-6 points: The patient has obvious pain, which affects the quality of sleep, but is still tolerable.

[0105] ④7-10 points: The patient experiences severe pain that is unbearable and affects sleep quality and appetite.

[0106] 2. Serum pain mediator levels: including the levels of serum prostaglandin E2 (PGE2), substance P (SP), serotonin (5-HT), and interleukin-1β (IL-1β) in 10 groups of patients before treatment and two weeks after treatment.

[0107] 3. Efficacy evaluation: refer to the relevant efficacy judgment standards in the Traditional Chinese Medicine Industry Standard of the People's Republic of China "Standards for Diagnosis and Efficacy of Traditional Chinese Medicine Diseases and Syndromes" (ZY / T001.1-94) and "Guiding Principles for Clinical Research of New Traditional Chinese Medicines".

[0108] The standards are as follows:

[0109] Cured: Muscle soreness, joint stiffness, difficulty in movement, limb numbness and other related symptoms completely disappeared, and the patient's daily life and work were not affected at all;

[0110] Significantly effective: symptoms such as muscle soreness, joint stiffness, difficulty in movement, and limb numbness have basically disappeared, with occasional mild pain and discomfort, which has little impact on daily life and work;

[0111] Effective: Symptoms related to muscle soreness, joint stiffness, difficulty in movement, and limb numbness are alleviated, and the disease relapses after treatment is stopped, causing some interference with daily life and work;

[0112] Ineffective: Symptoms such as muscle soreness, joint stiffness, difficulty in movement, and limb numbness were not relieved, seriously interfering with daily life and work.

[0113] Statistical methods: SPSS16.0 statistical software was used to organize and analyze the data. The measurement data that conformed to the normal distribution were expressed as ±s. The paired t test was used for comparison before and after treatment in the same group, and the independent sample t test was used for comparison between groups; the rank sum test was used for non-normal distribution measurement data. The chi-square test was used for non-rank data in the count data. For the two-sided test, P<0.05 was considered statistically significant.

[0114] result:

[0115] Description: Serum prostaglandin E2 (PGE2), substance P (SP), serotonin (5-HT), interleukin-1β (IL-1β)

[0116] Results of Group 1 (Neck Bi Group):

[0117] ① There was no statistically significant difference in the levels of related pain mediators between the two groups before treatment, and they were comparable (P>0.05);

[0118] ② Intra-group comparison, the levels of related pain media in the two groups of patients were significantly improved two weeks after treatment compared with before treatment, and the difference was statistically significant (P<0.05). At the two-week treatment time point between the two groups, the related indicators of the treatment group were better than those of the control group, and the difference was statistically significant (P<0.05) (see Table 1).

[0119] Table 1 Comparison of serum pain mediator levels in group 1 (neck pain group) before and after treatment

[0120]

[0121] Note: ①Compared with the group before treatment, P < 0.05; ②Compared with the control group after treatment, P < 0.05

[0122] Results of Group 2 (lumbar paralysis group):

[0123] ① There was no statistically significant difference in the levels of related pain mediators between the two groups before treatment, and they were comparable (P>0.05);

[0124] ② Intra-group comparison, the levels of related pain media in the two groups of patients were significantly improved two weeks after treatment compared with before treatment, and the difference was statistically significant (P<0.05). At the two-week treatment time point between the two groups, the related indicators of the treatment group were better than those of the control group, and the difference was statistically significant (P<0.05) (see Table 2).

[0125] Table 2 Comparison of serum pain mediator levels in the two groups (lumbar arthritis group) before and after treatment

[0126]

[0127] Note: ①Compared with the group before treatment, P < 0.05; ②Compared with the control group after treatment, P < 0.05

[0128] Results of group 3 (shoulder paralysis group):

[0129] There was no significant difference in the levels of related pain mediators between the two groups before treatment, and the two groups were comparable (P>0.05). There was no significant difference in the levels of related pain mediators between the two groups before treatment, and the two groups were comparable (P>0.05). There was a significant difference in the levels of related pain mediators between the two groups after two weeks of treatment, and the difference was statistically significant (P<0.05). At the two-week treatment time point, the related indicators of the treatment group were better than those of the control group, and the difference was statistically significant (P<0.05) (see Table 3).

[0130] Table 3 Comparison of serum pain mediator levels in the three groups (shoulder arthritis group) before and after treatment

[0131]

[0132] Note: ①Compared with the group before treatment, P < 0.05; ②Compared with the control group after treatment, P < 0.05

[0133] Results of Group 4 (bone arthritis group):

[0134] There was no significant difference in the levels of related pain mediators between the two groups before treatment, and the two groups were comparable (P>0.05). There was no significant difference in the levels of related pain mediators between the two groups before treatment, and the two groups were comparable (P>0.05). There was a significant difference in the levels of related pain mediators between the two groups after two weeks of treatment, and the difference was statistically significant (P<0.05). At the two-week treatment time point, the related indicators of the treatment group were better than those of the control group, and the difference was statistically significant (P<0.05) (see Table 4).

[0135] Table 4 Comparison of serum pain mediator levels in 4 groups (bone arthritis group) before and after treatment

[0136]

[0137]

[0138] Note: ①Compared with the group before treatment, P < 0.05; ②Compared with the control group after treatment, P < 0.05

[0139] Results of Group 5 (Muscle Bi Group):

[0140] ① There was no statistically significant difference in the levels of related pain mediators between the two groups before treatment, and they were comparable (P>0.05);

[0141] ② Intra-group comparison, the levels of related pain media in the two groups of patients were significantly improved two weeks after treatment compared with before treatment, and the difference was statistically significant (P<0.05). At the two-week treatment time point between the two groups, the related indicators of the treatment group were better than those of the control group, and the difference was statistically significant (P<0.05) (see Table 2).

[0142] Table 5 Comparison of serum pain mediator levels in 5 groups (muscle arthritis group) before and after treatment

[0143]

[0144] Note: ①Compared with the group before treatment, P < 0.05; ②Compared with the control group after treatment, P < 0.05

[0145] Comparison of the effective rates between the two groups

[0146] The total effective rate of the control group was 95% (285 / 300), and the total effective rate of the treatment group was 96% (290 / 300). The total effective rate of the two groups was not statistically significant by rank sum test (P>0.05). The cure rate of the control group was 63% (188 / 300), and the cure rate of the treatment group was 75% (224 / 300). The cure rate of the two groups was statistically significant by rank sum test (P<0.05) (see Table 6 and Figure 2 ).

[0147] Table 6 Comparison of overall efficacy between the two groups of patients after 2 weeks of treatment (cases)

[0148]

[0149] Example 3

[0150] Ling, male, 54 years old, Shanghai Seventh People's Hospital, hospital number: 642694

[0151] Initial diagnosis: Chief complaint: Recurrent stiffness and pain in the neck accompanied by numbness in the right upper limb for 1 week.

[0152] Medical history: The patient developed stiffness and pain in the neck after working hard with his head down one week ago, and gradually developed numbness and discomfort in the right upper limb, without dizziness, and denied a history of trauma. The patient was treated in the outpatient clinic, and cervical MRI examination showed: 1. Protrusion of the intervertebral discs from C4-5 to C6-7; 2. Cervical bone hyperplasia and straightening of the physiological curvature. On admission, the patient had stiffness in the neck, stiffness and pain in the trapezius muscle, and numbness in the right upper arm. The condition worsened after fatigue, good appetite, poor sleep at night, and regular bowel movements.

[0153] Tongue and pulse: dark tongue with thin white coating and stringy pulse.

[0154] Examination: poor cervical spine activity, stiffness, top percussion test (+), right brachial plexus traction test (+), right upper arm feeling slightly weaker than the left, Hoffman sign (-), upper limb muscle strength and muscle tension are normal. Auxiliary examination: cervical MRI examination shows: 1. Cervical 4-5 to C6-7 intervertebral disc protrusion; 2. Cervical bone hyperplasia, physiological curvature straightening. Scale score: VAS: 7 points, JOA score: 13 points.

[0155] Syndrome differentiation: Qi stagnation and blood stasis syndrome

[0156] Diagnosis: Western medicine diagnosis: cervical disc herniation, cervical osteoarthritis

[0157] TCM diagnosis: cervical spondylosis (neck pain)

[0158] Treatment principle: regulating qi and removing blood stasis, unblocking meridians and relieving pain

[0159] Prescription: Chinese herbal decoction 1#, 7 doses for external use. Second diagnosis: After the patient heated the Chinese herbal decoction and applied it continuously, the pain and stiffness in the neck were partially improved, the flexion and extension of the cervical spine were significantly improved, and the numbness of the upper arm was partially relieved. Tongue and pulse were the same as before. Scale score: VAS: 5 points, JOA score: 13 points. The above method was still followed and 7 doses of the above prescription were given.

[0160] Follow-up: After 2 weeks of medication, neck pain, stiffness and upper arm numbness were significantly improved, appetite was good, sleep was good at night, tongue was pale with thin white fur and pulse was stringy. Scale score: VAS: 2 points, JOA score: 16 points.

[0161] Example 4

[0162] Qiu, female, 46 years old, Shanghai Seventh People's Hospital, hospital number: 653511

[0163] Initial diagnosis: Chief complaint: Lumbar pain with radiating pain in the right lower limb for 2 days.

[0164] Medical history: The patient had lumbar pain after sitting for a long time yesterday, and gradually developed radiating pain in the right lower limb. He denied a history of trauma. The patient was treated in the outpatient clinic, and lumbar MRI examination showed: 1. Lumbar 4-5 intervertebral disc herniation (right lateral type); 2. Lumbar vertebrae hyperplasia and Schmor's nodes. When admitted to the hospital, he had lumbar pain, stiffness of the back muscles, radiating pain in the right lower limb, and the condition worsened after bending over and other activities. His appetite was good, his sleep was poor, and his bowel movements were normal.

[0165] Tongue and pulse: dark tongue with thin white coating and stringy pulse.

[0166] Examination: poor lumbar spine activity, stiffness, straight leg raising test: left 70° right 45°, femoral nerve traction test (-), hip and knee flexion test (-), normal sensation in both lower limbs, normal muscle strength and tension in the lower limbs, normal knee and ankle reflexes in the lower limbs. Auxiliary examination: Lumbar MRI examination suggests: 1. Lumbar 4-5 intervertebral disc herniation (right lateral type); 2. Lumbar bone hyperplasia and Schmor's nodes. Scale score: VAS: 8 points, Oswestry Disability Index (ODI) score: 20 points.

[0167] Syndrome differentiation: Qi stagnation and blood stasis syndrome

[0168] Diagnosis: Western medicine diagnosis: Lumbar disc herniation, lumbar osteoarthritis

[0169] TCM diagnosis: Lumbar paralysis

[0170] Treatment principle: regulating qi and removing blood stasis, unblocking meridians and relieving pain

[0171] Prescription: Chinese herbal decoction 2#, 7 doses for external use. Second diagnosis: After the patient heated the Chinese herbal decoction and applied it externally continuously, the soreness and stiffness in the lumbar sacral region were partially improved, the flexion and extension of the lumbar spine were significantly improved, and the radiating pain in the right lower limb was partially relieved. Tongue and pulse were the same as before. Scale score: VAS: 5 points, ODI score: 15 points. The above method was still followed and 7 doses of the above prescription were given.

[0172] Follow-up: After 2 weeks of medication, the pain in the lumbar region and the radiating pain in the right lower limb were significantly improved, the appetite was good, the sleep was good at night, the tongue was pale, the coating was thin and white, and the pulse was stringy. Scale score: VAS: 3 points, ODI score: 10 points.

[0173] Example 5

[0174] Zhang, female, 54 years old, Shanghai Seventh People's Hospital, hospital number: 667323

[0175] Initial diagnosis: Chief complaint: left shoulder pain with limited movement for more than 5 months.

[0176] Medical history: The patient had repeated left shoulder pain without obvious cause in the past five months. The pain was persistent and dull, which worsened at night and after catching a cold, affecting sleep. At the same time, the shoulder movement was limited, and the abduction, lifting, and extension movements were significantly limited, making it difficult to dress and comb the hair. The symptoms were generally relieved by self-application of analgesic plasters. When admitted to the hospital, the shoulder pain was aggravated by cold and relieved by warmth, accompanied by heaviness and fatigue of the limbs, good appetite, poor sleep at night, and regular bowel movements.

[0177] Tongue and pulse: pale tongue with thin white coating and tight pulse.

[0178] Examination: The left shoulder is limited in motion, and the abduction, elevation, and extension of the shoulder joint are all limited. The pain is aggravated by passive motion. The shoulder muscles are tense, and the tenderness of the shoulder area is obvious, especially under the acromion, coracoid process, and greater tuberosity.

[0179] Shoulder test (+), ruler test (+), no obvious atrophy of muscles around the shoulder joint. Auxiliary examination: Left shoulder X-ray: left shoulder bone hyperplasia. Scale score: VAS: 8 points, Constant-Murley shoulder joint scoring scale score: 65 points.

[0180] Syndrome differentiation: Cold-dampness obstruction syndrome

[0181] Diagnosis: Western medicine diagnosis: shoulder periarthritis

[0182] TCM diagnosis: Shoulder pain

[0183] Treatment principle: warming the meridians and dispelling cold, unblocking the meridians and relieving pain

[0184] Prescription: Chinese herbal decoction 3#, 7 doses for external use. Second diagnosis: After the patient heated the Chinese herbal decoction and applied it continuously, the shoulder pain was partially improved, and the left shoulder movement was significantly improved. Tongue and pulse were the same as before. Scale score: VAS: 6 points, Constant-Murley shoulder joint scoring scale score: 75 points. Still follow the above method and give 7 doses of the above prescription.

[0185] Follow-up: After 2 weeks of medication, the pain and limited activity of the left shoulder were significantly improved, the appetite was good, the sleep was good, the tongue was pale, the coating was thin, and the pulse was white. Scale score: VAS: 3 points, Constant-Murley shoulder joint scoring scale score: 80 points.

[0186] Example 6

[0187] Zhou, male, 46 years old, Shanghai Seventh People's Hospital, hospital number: 668052

[0188] Initial visit: Chief complaint: right knee pain for 3 months.

[0189] Medical history: The patient had repeated right knee pain and discomfort in the past three months. The pain worsened when going up and down stairs, and there was a popping sensation from time to time. He denied a clear history of trauma. Outpatient MRI examination of the knee joint showed: right knee degeneration, medial meniscus injury, and a small amount of fluid accumulation in the knee joint cavity and suprapatellar bursa. When he was admitted to the hospital, he had knee pain, mild swelling, poor flexion and extension, and his condition worsened after walking and other fatigue. His appetite was good, his sleep was poor, and his bowel movements were normal.

[0190] Tongue and pulse: dark tongue with thin white coating and stringy pulse.

[0191] Examination: right knee stiffness, slightly unfavorable flexion and extension, mild swelling around the patella, floating patella test (-), extrusion and grinding test (+), McBurney sign (++), drawer test (-). Auxiliary examination: knee MR examination showed: right knee degeneration, medial meniscus injury, a small amount of effusion in the knee joint cavity and suprapatellar bursa. Scale score: VAS: 8 points, WOMAC scale: 65 points.

[0192] Syndrome differentiation: Qi stagnation and blood stasis syndrome

[0193] Diagnosis: Western medicine diagnosis: right knee osteoarthritis, right knee meniscus injury

[0194] TCM diagnosis: knee arthritis

[0195] Treatment principle: regulating qi and removing blood stasis, unblocking meridians and relieving pain

[0196] Prescription: Chinese herbal decoction 4#, 7 doses for external use. Second diagnosis: After the patient heated the Chinese herbal decoction and applied it externally, the pain and stiffness of the knee were partially improved, the swelling of the knee joint was significantly improved, and he could fall asleep smoothly at night. Tongue and pulse were the same as before. Scale score: VAS: 5 points, WOMAC scale: 32 points. The above method was still followed and 7 doses of the above prescription were given.

[0197] Follow-up: After 2 weeks of medication, knee pain, stiffness and swelling were significantly improved, appetite was good, sleep was good at night, tongue was pale with thin white fur and pulse was stringy. Scale score: VAS: 2 points, WOMAC scale: 16 points.

[0198] Example 7

[0199] Ms. Cao, female, 48 years old, Shanghai Seventh People's Hospital, outpatient number: P09265621

[0200] Initial visit: Chief complaint: right heel pain for more than 2 weeks.

[0201] Medical history: The patient had right heel pain after fatigue in the past two weeks. The pain was like a thorn and had a fixed location. The patient refused to press. The pain worsened after walking or standing for a long time. There was no obvious redness or swelling in the heel, the patient had a good appetite, slept well at night, and had normal bowel movements.

[0202] Tongue and pulse: dark tongue with thin white coating and tight pulse.

[0203] Examination: right foot flat foot, normal ankle dorsiflexion and plantar flexion, tenderness of medial calcaneal tuberosity (++), plantar fascia tension test (++), normal toe sensation and circulation. Auxiliary examination: right calcaneal X-ray: right calcaneal bone spur is forming. Scale score: VAS: 8 points.

[0204] Syndrome differentiation: Qi stagnation and blood stasis syndrome

[0205] Diagnosis: Western medicine diagnosis: Heel pain (plantar fasciitis)

[0206] TCM diagnosis: tendon arthritis

[0207] Treatment principle: regulating qi and removing blood stasis, unblocking meridians and relieving pain

[0208] Prescription: Chinese herbal decoction 5#, a total of 7 doses for external use. Second diagnosis: The patient's plantar pain was partially improved after continuous external application of the heated Chinese herbal decoction. Scale score: VAS: 6 points. The above method was still followed and 7 doses of the above prescription were given.

[0209] Follow-up: After 2 weeks of medication, the pain in the soles of the feet was significantly improved, the appetite was good, the sleep was good, the tongue was pale, the coating was thin and the pulse was white. Scale score: VAS: 2 points.

[0210] The basic concepts have been described above. Obviously, for those skilled in the art, the above detailed disclosure is only for example and does not constitute a limitation of this specification. Although not explicitly stated here, those skilled in the art may make various modifications, improvements and corrections to this specification. Such modifications, improvements and corrections are suggested in this specification, so such modifications, improvements and corrections still belong to the spirit and scope of the exemplary embodiments of this specification.

[0211] At the same time, this specification uses specific words to describe the embodiments of this specification. For example, "one embodiment", "an embodiment", and / or "some embodiments" refer to a certain feature, structure or characteristic related to at least one embodiment of this specification. Therefore, it should be emphasized and noted that "one embodiment" or "an embodiment" or "an alternative embodiment" mentioned twice or more in different positions in this specification does not necessarily refer to the same embodiment. In addition, certain features, structures or characteristics in one or more embodiments of this specification can be appropriately combined.

[0212] In some embodiments, numbers describing the number of components and attributes are used. It should be understood that such numbers used in the description of the embodiments are modified by the modifiers "about", "approximately" or "substantially" in some examples. Unless otherwise specified, "about", "approximately" or "substantially" indicate that the numbers are allowed to vary by ±20%. Accordingly, in some embodiments, the numerical parameters used in the specification and claims are approximate values, which may change according to the required features of individual embodiments. In some embodiments, the numerical parameters should take into account the specified significant digits and adopt the general method of retaining digits. Although the numerical domains and parameters used to confirm the breadth of their range in some embodiments of this specification are approximate values, in specific embodiments, the setting of such numerical values ​​is as accurate as possible within the feasible range.

[0213] Finally, it should be understood that the embodiments described in this specification are only used to illustrate the principles of the embodiments of this specification. Other variations may also fall within the scope of this specification. Therefore, as an example and not a limitation, alternative configurations of the embodiments of this specification may be considered consistent with the teachings of this specification. Accordingly, the embodiments of this specification are not limited to the embodiments explicitly introduced and described in this specification.

Claims

1. A Chinese medicine composition, comprising the following raw material components by weight: 10-40 parts of turmeric, 10-30 parts of rhubarb, 20-45 parts of cassia twig, 20-45 parts of stir-fried mulberry twig, 15-45 parts of kudzu root, 10-45 parts of sappan wood, 15-45 parts of lycopodii herba, 10-45 parts of ligusticum chuanxiong, and 10-45 parts of cyathula capitata.

2. The Chinese medicine composition according to claim 1, characterized in that The raw material components include: 10-30 parts of turmeric, 10-20 parts of rhubarb, 20-30 parts of cassia twig, 20-30 parts of stir-fried mulberry twig, 15-30 parts of kudzu root, 10-30 parts of sappan wood, 15-30 parts of lycopodii herba, 10-30 parts of ligusticum chuanxiong, and 10-30 parts of cyathula capitata.

3. The Chinese medicine composition according to claim 1, characterized in that: The raw material components include: 10 parts of turmeric, 10 parts of rhubarb, 20 parts of cassia twig, 20 parts of stir-fried mulberry twig, 15 parts of kudzu root, 10 parts of sappan wood, 15 parts of lycopodii herba, 10 parts of ligusticum chuanxiong, and 10 parts of cyathula capitata.

4. A Chinese medicine preparation, prepared from the Chinese medicine composition according to any one of claims 1 to 3 as a raw material.

5. The Chinese medicine preparation according to claim 4, characterized in that: The Chinese medicine composition according to any one of claims 1 to 3 is decocted with water and filtered to obtain the Chinese medicine preparation.

6. The Chinese medicine preparation according to claim 4, characterized in that: The Chinese medicine preparation includes Chinese medicine decoction and / or coarse granular medicinal residue; And / or, before decoction, soak the Chinese medicine composition in water for 30 minutes to 1 hour; And / or, during the decocting process, rhubarb is added later.

7. Use of the Chinese medicine composition according to any one of claims 1 to 3 or the Chinese medicine preparation according to claim 4 in the preparation of drugs for preventing and / or treating chronic bone and muscle diseases.

8. The use according to claim 7, characterized in that The chronic bone and muscle diseases include spinal degenerative diseases, bone and joint degenerative diseases, soft tissue diseases or bone metabolic diseases.

9. The use according to claim 8, characterized in that The spinal degenerative diseases include cervical spondylosis and lumbar spondylosis; and / or, the bone and joint degenerative diseases include hip / knee osteoarthritis; And / or, the soft tissue diseases include frozen shoulder, rotator cuff injury, meniscus injury, lateral epicondylitis or myofasciitis; And / or, the bone metabolic disease includes osteoporosis.

10. The use according to claim 7, characterized in that The drug reduces the level of serum pain mediators, preferably, the drug reduces the level of serum prostaglandin E2, substance P, serotonin or interleukin-1β; And / or, the chronic bone and muscle disease includes at least one of cervical disc herniation, cervical osteoarthritis, lumbar disc herniation, lumbar osteoarthritis, periarthritis of the shoulder, knee osteoarthritis or plantar fasciitis.

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