External traditional Chinese medicine formula for reducing uric acid and preparation method of external traditional Chinese medicine formula

Abstract

The invention discloses an external traditional Chinese medicine formula for reducing uric acid and a preparation method thereof. The invention relates to a pharmaceutical composition for reducing uric acid, in particular to a medicament for reducing uric acid, which is prepared from plant Chinese herbal medicines as raw materials. Hyperuricemia is a common disease in modern society, brings great pain to patients, and urgently needs a traditional Chinese medicine preparation which can efficiently relieve hyperuricemia and keep blood uric acid constant. Therefore, development of a traditional Chinese medicine preparation which is efficient, convenient to use and small in side effect has important significance. The invention firstly discloses the external traditional Chinese medicine composition for reducing uric acid. The external traditional Chinese medicine composition comprises rhizoma atractylodis, cortex phellodendri, radix cyathulae, semen coicis, garden balsam stem, spina gleditsiae, sargentgloryvine stem, lycopodium clavatum, radix paeoniae alba and rhizoma smilacis glabrae. The traditional Chinese medicine composition has the advantages that the traditional Chinese medicine composition is high in acid discharge effect, and uric acid can be obviously reduced; the preparation method of the external preparation provided by the invention is simple and easy to implement.

Description

Technical Field:

[0001] The present invention relates to a drug combination for reducing uric acid, and particularly to a drug for reducing uric acid prepared from plant Chinese herbal medicines. Background Art:

[0002] Under normal purine diet conditions, hyperuricemia can be diagnosed if the blood uric acid level exceeds 420 μmol / L on two non - consecutive days. In recent years, with the improvement of the living standards of Chinese people, the prevalence risk of hyperuricemia has been increasing year by year, and the prevalence rate of hyperuricemia in China has reached as high as 13.3%. Hyperuricemia is a risk factor for many diseases and an independent risk factor for cardiovascular diseases, kidney diseases, and hypertension, seriously damaging people's physical health. At present, although the drugs for treating hyperuricemia in domestic clinics can significantly reduce the serum uric acid concentration of patients, long - term use will produce adverse reactions and cause damage to the body. Hyperuricemia is a common disease in modern society, bringing great pain to patients. There is an urgent need for a traditional Chinese medicine preparation that can effectively relieve symptoms and maintain a constant blood uric acid level to meet clinical needs. Therefore, it is of great significance to develop a traditional Chinese medicine preparation with high efficiency, convenient use, and few side effects.

[0003] In the traditional Chinese medicine theory system, hyperuricemia belongs to the categories of arthralgia syndrome, bi syndrome, gout, etc. Its disease location is in the kidney and is closely related to organs such as the liver and spleen. In recent years, with the continuous exploration of hyperuricemia, traditional Chinese medicine has basically summarized the pathogenesis of this disease into three aspects: deficiency of the spleen and kidney, internal accumulation of damp - turbidity; dysfunction of the spleen in transportation and transformation, and disorder of the ascending and descending of the spleen and stomach in clearing and descending turbidity; inability of the kidney qi to transform, and loss of the function of separating and excreting turbidity, resulting in the endogenous generation of damp - turbidity, which accumulates for a long time and forms uric acid turbidity toxin. Therefore, traditional Chinese medicine often uses traditional Chinese medicines such as tonics, heat - clearing drugs, blood - activating and stasis - removing drugs, and exterior - relieving drugs to treat hyperuricemia in clinical practice.

[0004] Based on traditional Chinese medicine and modern medical theories, the present invention has verified the safety and effectiveness of the formula and preparation through repeated experiments. Summary of the Invention:

[0005] The first object of the present invention is to provide a traditional Chinese medicine composition with a therapeutic effect on hyperuricemia according to traditional Chinese medicine theory.

[0006] The second object of the present invention is to provide an external preparation containing the above - mentioned traditional Chinese medicine composition and its preparation method.

[0007] To achieve the above objects, the present invention adopts the following technical solutions:

[0008] The present invention first discloses an external-use traditional Chinese medicine composition for reducing uric acid, which is characterized in that the traditional Chinese medicine composition comprises the following raw medicinal materials in parts by mass: Atractylodes lancea 150 - 300 parts, Phellodendron amurense 100 - 300 parts, Cyathula officinalis 200 - 300 parts, Coix lacryma-jobi 150 - 300 parts, Speranskia tuberculata 150 - 300 parts, Gleditsia sinensis 150 - 300 parts, Sargentodoxa cuneata 150 - 300 parts, Lycopodium clavatum 100 - 300 parts, Paeonia lactiflora 150 - 300 parts, Smilax glabra 150 - 300 parts.

[0009] The present invention also discloses an external preparation, which is prepared from the above-mentioned traditional Chinese medicine composition. The preparation method of the preparation:

[0010] Atractylodes lancea 150 - 300 parts, Phellodendron amurense 100 - 300 parts, Cyathula officinalis 200 - 300 parts, Coix lacryma-jobi 150 - 300 parts, Speranskia tuberculata 150 - 300 parts, Gleditsia sinensis 150 - 300 parts, Sargentodoxa cuneata 150 - 300 parts, Lycopodium clavatum 100 - 300 parts, Paeonia lactiflora 150 - 300 parts, Smilax glabra 150 - 300 parts. Mix the above raw materials evenly, add 2000 - 3000 ml of clear water, boil for 20 minutes, filter to remove the residue, and then put the medicinal liquid into a basin for use. Specific embodiments:

[0011] The main active ingredients and medicinal properties of each component in the traditional Chinese medicine composition of the present invention are as follows:

[0012] Atractylodes lancea: pungent and bitter in taste, warm in nature, attributing to the spleen, stomach and liver meridians. It mainly includes chemical components such as alkynes, sesquiterpenes, triterpenes, glycosides and sterols, etc., having effects of anti-ulcer, immune regulation, anti-inflammatory, etc., and having the effects of strengthening the spleen, eliminating dampness and expelling wind.

[0013] Phellodendron amurense: bitter in taste, cold in nature, attributing to the kidney and bladder meridians. It mainly includes chemical components such as alkaloids, limonoids, phenolic acids, phenylpropanoids, volatile oils, etc., having effects of anti-inflammatory, antibacterial, antioxidant, anti-tumor, hypoglycemic, nerve protection, antidiarrheal, etc., and having the effects of clearing away heat and drying dampness, purging fire and removing steaming, detoxifying and treating sores.

[0014] Cyathula officinalis: sweet and slightly bitter in taste, neutral in nature, attributing to the liver and kidney meridians. The main active ingredients are sterone, triterpenoid saponins and polysaccharides, having effects of anti-inflammatory, anti-tumor, lipid-lowering, anti-hypertensive, antioxidant, etc., and having the effects of promoting blood circulation and dredging meridians, dispelling wind and removing dampness, diuretic and relieving stranguria, etc.

[0015] Coix lacryma-jobi: sweet and light in taste, cool in nature, attributing to the spleen, stomach and lung meridians. It contains components such as esters, unsaturated fatty acids, saccharides, lactams, etc., having effects of anti-cancer, hypoglycemic, regulating lipid metabolism, antiviral, anti-obesity, antihypertensive, anti-inflammatory, improving immunity, regulating intestinal microbiota, preventing osteoporosis, etc., and having the effects of strengthening the spleen and tonifying the lung, clearing away heat and promoting diuresis, discharging pus and relieving arthralgia, antidiarrheal, etc.

[0016] Radix Pseudostellariae: Spicy, warm in nature, and enters the liver and kidney meridians. It contains chemical components such as flavonoids, alkaloids, naphthoquinones, and terpenes, and has anti-inflammatory, analgesic, anti-tumor, antibacterial, antioxidant, and insecticidal effects. It has the effects of dispelling wind and dampness, relaxing muscles, activating blood circulation, and relieving pain.

[0017] Gleditsia sinensis: spicy, warm in nature, enters the large intestine and lung meridians. Mainly contains triterpenes, saponins, flavonoids, phenolic acid, echinocystic acid glycosides, coumarins and other chemical components, which have antibacterial, antiviral, immunity-enhancing, antioxidant and other effects, and have the effects of reducing swelling and pus, dispelling wind and killing insects, opening and closing, promoting qi and dispersing stagnation, and clearing the mind.

[0018] Red vine: bitter, neutral in nature, enters the large intestine and liver meridians. It has antibacterial, anti-inflammatory, antiviral, anti-tumor, anti-radiation, anti-allergic effects, and has the effects of clearing away heat and detoxification, promoting blood circulation, dispelling wind, and relieving pain.

[0019] Herba Lycopodii: slightly bitter and pungent, warm in nature, enters the liver, spleen and kidney meridians. It mainly contains alkaloids, triterpenes, anthraquinones, volatile oils and other ingredients. It has anti-inflammatory, analgesic, antibacterial, acetylcholinesterase activity inhibition effects, and has the effects of dispelling wind and dampness, relaxing muscles and activating collaterals.

[0020] White peony root: bitter, sour, slightly cold, enters the liver and spleen meridians. Contains monoterpenes and their glycosides, triterpenes, flavonoids, tannins and other chemical components, has anti-inflammatory, liver protection, analgesic, blood nourishing and other pharmacological effects, and has the effects of nourishing blood and softening the liver, relieving pain, and concentrating yin and reducing sweat.

[0021] Smilax glabra: sweet, light, neutral in nature, enters the liver and stomach meridians. Contains chemical components such as sugars, organic acids, phenylpropanoids, flavonoids and flavonoid glycosides, sterols, saponins and volatile oils, and has anti-inflammatory and analgesic effects, as well as the effects of detoxification, dampness removal, cooling blood, detoxification, wind removal and pain relief.

[0022] Now, the present invention is described in detail with reference to the following embodiments:

[0023] 1. Mr. Du, male, 35 years old, had hyperuricemia for 11 years and gout stones. Before treatment, his uric acid level was 588.9 μmol / L. He was given 15g of Atractylodes lancea, 10g of Phellodendron chinense, 20g of Cyathula capitata, 30g of Coix seed, 30g of Radix Polygoni Multiflori, 30g of Gleditsia sinensis, 30g of Scutellaria baicalensis, 15g of Lycopodiella cuneata, 30g of White Peony Root, and 30g of Smilax glabra. He was fumigated and washed externally once a day. After rechecking, the uric acid level dropped to 372.4 μmol / L and the tophi stones softened.

[0024] 2. Wang, male, 34 years old, had a history of hyperuricemia for many years. Before treatment, his uric acid level was 420μmol / L. He was given 15g of Atractylodes lancea, 10g of Phellodendron chinense, 20g of Cyathula capitata, 30g of Coix seed, 30g of Radix Polygoni Multiflori, 30g of Gleditsia sinensis, 30g of Scutellaria baicalensis, 15g of Lycopodiella cuneata, 30g of White Peony Root, and 30g of Smilax glabra. He was used for external fumigation once a day. After rechecking, the uric acid level dropped to 397μmol / L.

[0025] The effects of the medicament of the present invention can be summarized as follows:

[0026] 1. The Chinese medicine composition of the present invention has a strong acid-removing effect and can significantly reduce uric acid;

[0027] 2. The preparation method of the preparation provided by the present invention is simple and easy to implement.

Claims

1. A Chinese herbal medicine for reducing uric acid and its preparation method, characterized in that, It consists of the following weight ratios: Atractylodes lancea 10 - 20 g, Phellodendron amurense 10 - 20 g, Cyathula officinalis 20 - 30 g, Coix lacryma-jobi 20 - 30 g, Speranskia tuberculata 20 - 30 g, Gleditsia sinensis 20 - 30 g, Sargentodoxa cuneata 20 - 30 g, Lycopodium clavatum 10 - 20 g, Paeonia lactiflora 20 - 30 g, Smilax glabra 20 - 30 g.

2. The Chinese herbal medicine for reducing uric acid and its preparation method according to claim 1, characterized in that, It consists of the following weight ratios: Atractylodes lancea 10 g, Phellodendron amurense 10 g, Cyathula officinalis 20 g, Coix lacryma-jobi 20 g, Speranskia tuberculata 20 g, Gleditsia sinensis 20 g, Sargentodoxa cuneata 20 g, Lycopodium clavatum 10 g, Paeonia lactiflora 20 g, Smilax glabra 20 g.

3. The Chinese herbal medicine for reducing uric acid and its preparation method according to claim 1, characterized in that, It consists of the following weight ratios: Atractylodes lancea 20 g, Phellodendron amurense 20 g, Cyathula officinalis 30 g, Coix lacryma-jobi 30 g, Speranskia tuberculata 30 g, Gleditsia sinensis 30 g, Sargentodoxa cuneata 30 g, Lycopodium clavatum 20 g, Paeonia lactiflora 30 g, Smilax glabra 30 g.

4. A Chinese herbal medicine for reducing uric acid and its preparation method according to claim 1, characterized in that, It consists of the following weight ratios: Atractylodes lancea 15 g, Phellodendron amurense 15 g, Cyathula officinalis 25 g, Coix lacryma-jobi 25 g, Speranskia tuberculata 25 g, Gleditsia sinensis 25 g, Sargentodoxa cuneata 25 g, Lycopodium clavatum 15 g, Paeonia lactiflora 25 g, Smilax glabra 25 g.

5. A Chinese herbal medicine for reducing uric acid and its preparation method according to claim 1, characterized in that, It includes the following steps: (1) Weigh according to the above weight ratios. (2) Mix and crush each herb in proportion, and add 2000 - 3000 ml of clear water, and boil for 20 minutes.