Natural plant essential oil emulsifiable paste composition for relieving male prostatic discomfort

Abstract

The invention provides a composition. The composition comprises extracts of one or more of borneol (blumea balsamifera), lysimachia tricolor, myrrh, tea trees, lemons, thyme, rosemary, cistanche, cynomorium songaricum, herba epimedii, mint, peach kernels, radix cyathulae, pogostemon cablin, pumpkin seeds, curcuma zedoary, rhizoma acori graminei and turmeric. The invention further provides a cream prepared from the extract (plant essential oil), and the cream is suitable for being smeared on the skin of the perineum or the prostate area and used for relieving prostate discomfort, especially prostatitis symptoms. The invention further provides a combined treatment method, namely the cream is combined with a quantum resonance instrument, and local stimulation with a certain frequency is applied, so that the transdermal absorption and anti-inflammatory effects of the medicine are enhanced, and the overall curative effect is improved.

Description

Technical Field

[0001] The present invention relates to the field of biomedicine, and in particular to a composition for relieving male prostate discomfort. Background Art

[0002] The prostate is a vital glandular organ unique to adult men. Located adjacent to the bladder outlet and the beginning of the urethra, it plays a key role in the male urinary and reproductive systems. In recent years, the incidence of prostate-related diseases has continued to rise, with the age of onset trending toward younger people, driven by factors such as an accelerated pace of life, prolonged sedentary lifestyles, and irregular diets.

[0003] Prostate discomfort is primarily manifested by symptoms such as perineal distension, weak urination, frequent urination, urgency, increased nocturia, painful ejaculation, and decreased sexual function, severely impacting patients' quality of life. Prostatitis is one of the most common pathological causes of prostate discomfort, particularly nonbacterial chronic prostatitis / chronic pelvic pain syndrome (NIH-III), which accounts for over 90% of all prostatitis patients and is characterized by a prolonged course, high recurrence rates, and difficulty in treatment.

[0004] Current treatments for prostatitis primarily include antibiotics, alpha-blockers, and botanical preparations, with some patients also supplemented with prostate massage or physical therapy. However, these treatments present numerous challenges: antibiotics have limited effectiveness against nonbacterial inflammation, and long-term use can easily lead to drug resistance and disrupt intestinal flora; alpha-blockers have common side effects, including decreased blood pressure, dizziness, and fatigue, leading to poor compliance; oral Chinese patent medicines are absorbed through the digestive tract, resulting in poor targeting and slow onset of action; and the unique anatomy of the prostate makes it difficult for drugs to effectively penetrate the barrier and act on the prostate parenchyma, creating a therapeutic bottleneck.

[0005] Furthermore, there is a lack of effective, convenient, and safe topical treatment options specifically designed for the prostate area. While some plant essential oils currently exhibit certain biological activities in terms of anti-inflammatory, analgesic, and blood circulation, their effectiveness is significantly limited by limitations such as the skin barrier.

[0006] Therefore, there is an urgent need to develop an innovative treatment plan that synergistically enhances the external penetration ability of herbal medicines and has both local regulation and systemic conditioning effects, so as to improve prostate discomfort symptoms, relieve inflammatory responses and improve patient compliance. Summary of the Invention

[0007] After years of experimentation, product development, testing, and formula adjustments, the inventors developed the present composition and cream. Based on clinical experience and differentiated by different symptom manifestations, they primarily target a range of symptoms caused by the prostate, including prostatitis, weak and delayed urination, frequent urination at night, frequent urination, urgency, urinary emergencies, and scrotal moisture.

[0008] The present invention provides a formula / composition containing borneol (Bombyx Balsamifera), Herba Myrrhae, Camellia Sinensis, lemon, thyme, rosemary, Cistanche Deserticola, Cynomorium Songaricum, and Epimedium. Further formulas / compositions containing Herba Blumea Balsamifera, Herba Myrrhae, Camellia Sinensis, lemon, thyme, rosemary, Cistanche Deserticola, Cynomorium Songaricum, Epimedium, mint, peach kernel, Cyathula officinalis, patchouli, pumpkin seed, Curcuma Rhizome, Acorus Gramineus, and Curcuma Longa are provided. These formulas / compositions can be used to treat prostatitis, particularly the latter.

[0009] The formula can be mixed in different proportions in the form of 100% natural plant essential oils, and emulsified, and then the quantum resonance technology process is added.

[0010] The formula of the present invention is made into a cream and applied to the perineum and its surrounding area, which mainly has the following functions: rapid penetration and anti-inflammation, softening and dispersing lumps, activating tissues and enhancing energy.

[0011] In one aspect of the present invention, a composition is provided, comprising: Artemisia argyi, Herba Myrrhae, Camellia sinensis, Lemon, Thyme, Rosemary, Cistanche deserticola, Cynomorium songaricum, Epimedium, Mint, Peach Kernel, Cyathula officinalis, Patchouli, Pumpkin Seed, Curcuma zedoaria, Acorus calamus and Turmeric.

[0012] In some embodiments of the present invention, a composition is provided, comprising: 20-40 parts by weight of Blumea balsamifera, 3-8 parts by weight of Herba Myrrhae, 10-30 parts by weight of Myrrha, 3-8 parts by weight of Camellia sinensis, 30-50 parts by weight of lemon, 10-30 parts by weight of Thyme, 3-8 parts by weight of Rosemary, 0.5-2 parts by weight of Cistanche deserticola, 1-5 parts by weight of Cynomorium songaricum, 5-15 parts by weight of Epimedium, 5-15 parts by weight of Menthol, 10-20 parts by weight of Peach Kernel, 10-20 parts by weight of Cyathula, 20-40 parts by weight of Patchouli, 20-40 parts by weight of Pumpkin Seeds, 3-8 parts by weight of Curcuma zedoaria, 3-8 parts by weight of Acorus calamus, and 5-15 parts by weight of Curcuma longa.

[0013] In some embodiments of the present invention, the composition is composed of: 20-40 parts by weight of Blumea balsamifera, 3-8 parts by weight of Herba Myrrhae, 10-30 parts by weight of Camellia sinensis, 30-50 parts by weight of lemon, 10-30 parts by weight of thyme, 3-8 parts by weight of rosemary, 0.5-2 parts by weight of Cistanche deserticola, 1-5 parts by weight of Cynomorium songaricum, 5-15 parts by weight of Epimedium, 5-15 parts by weight of mint, 10-20 parts by weight of peach kernel, 10-20 parts by weight of Cyathula officinalis, 20-40 parts by weight of Patchouli, 20-40 parts by weight of pumpkin seeds, 3-8 parts by weight of Curcuma zedoaria, 3-8 parts by weight of Acorus calamus, and 5-15 parts by weight of turmeric.

[0014] In some embodiments of the present invention, the composition comprises: 30 parts by weight of Blumea balsamifera, 5 parts by weight of Herba Myrrhae, 20 parts by weight of Myrrha, 5 parts by weight of Camellia sinensis, 40 parts by weight of lemon, 20 parts by weight of Thyme, 5 parts by weight of Rosemary, 1 part by weight of Cistanche deserticola, 3 parts by weight of Cynomorium songaricum, 10 parts by weight of Epimedium, 10 parts by weight of Menthol, 15 parts by weight of Peach Kernel, 15 parts by weight of Cyathula, 30 parts by weight of Patchouli, 30 parts by weight of Pumpkin Seeds, 5 parts by weight of Curcuma zedoaria, 5 parts by weight of Acorus calamus and 10 parts by weight of Curcuma longa.

[0015] In some embodiments of the present invention, the composition is composed of: 30 parts by weight of Blumea balsamifera, 5 parts by weight of Herba Myrrha, 20 parts by weight of Camellia sinensis, 40 parts by weight of lemon, 20 parts by weight of thyme, 5 parts by weight of Rosemary, 1 part by weight of Cistanche deserticola, 3 parts by weight of Cynomorium songaricum, 10 parts by weight of Epimedium, 10 parts by weight of Menthol, 15 parts by weight of Peach Kernel, 15 parts by weight of Cyathula, 30 parts by weight of Patchouli, 30 parts by weight of Pumpkin Seeds, 5 parts by weight of Curcuma zedoaria, 5 parts by weight of Acorus calamus and 10 parts by weight of Curcuma longa.

[0016] In some embodiments of the present invention, a composition is provided, comprising: 20-40 parts by weight of Blumea balsamifera extract, 3-8 parts by weight of Herba Myrrhae Officinalis extract, 10-30 parts by weight of Myrrha myrrh extract, 3-8 parts by weight of Camellia sinensis extract, 30-50 parts by weight of lemon extract, 10-30 parts by weight of Thyme extract, 3-8 parts by weight of Rosemary extract, 0.5-2 parts by weight of Cistanche deserticola extract, 1-5 parts by weight of Cynomorium songaricum extract, 5-15 parts by weight of Epimedium extract, 5-15 parts by weight of Peppermint extract, 10-20 parts by weight of Peach Kernel extract, 10-20 parts by weight of Cyathula officinalis extract, 20-40 parts by weight of Patchouli extract, 20-40 parts by weight of Pumpkin Seed Extract, 3-8 parts by weight of Curcuma zedoaria extract, 3-8 parts by weight of Acorus calamus extract, and 5-15 parts by weight of Curcuma longa extract.

[0017] Optionally, the preparation method of the extract of the present invention is: take the botanical materials (i.e., any one of Blumea balsamifera, Herba Myrrha, Camellia sinensis, Lemon, Thyme, Rosemary, Cistanche deserticola, Cynomorium songaricum, Epimedium, Mint, Peach Kernel, Cynomorium songaricum, Patchouli, Pumpkin Seed, Curcuma zedoaria, Acorus calamus and Turmeric), crush them, add a mixed solvent of n-hexane-ethyl acetate with a volume ratio of 3:1, let it stand at room temperature, filter, and evaporate the filtrate to dryness to obtain the extract.

[0018] Optionally, the extract of the present invention is prepared by: taking the botanical material, crushing it, adding 3-7 times its weight of a mixed solvent of n-hexane-ethyl acetate with a volume ratio of 3:1, standing at room temperature, filtering, and evaporating the filtrate to dryness.

[0019] Optionally, the extract is prepared by: taking the botanical material, crushing it, adding about 5 times its weight of a mixed solvent of n-hexane-ethyl acetate in a volume ratio of 3:1, standing at room temperature, filtering, and evaporating the filtrate to dryness.

[0020] The plant medicinal material is any one of Blumea balsamifera, Herba Myrrhae, Myrrha, Tea Tree, Lemon, Mushroom, Rosemary, Cistanche deserticola, Cynomorium songaricum, Epimedium, Mint, Peach Kernel, Cyathula officinalis, Patchouli, Pumpkin Seed, Curcuma zedoaria, Acorus calamus and Turmeric.

[0021] Optionally, the preparation method of the extract of the present invention is: take the botanical material, wash, dry, and crush, take 150 g, add 1 liter of a mixed solvent of n-hexane and ethyl acetate with a volume ratio of 3:1, let it stand at room temperature for 10 days, filter, and evaporate the filtrate under reduced pressure at 30 degrees Celsius to dryness.

[0022] In some embodiments of the present invention, the composition is composed of 20-40 parts by weight of Blumea balsamifera extract, 3-8 parts by weight of Herba Myrrhae Officinalis extract, 10-30 parts by weight of Myrrha Myrrha extract, 3-8 parts by weight of Camellia sinensis extract, 30-50 parts by weight of lemon extract, 10-30 parts by weight of Thyme extract, 3-8 parts by weight of Rosemary extract, 0.5-2 parts by weight of Cistanche deserticola extract, 1-5 parts by weight of Cynomorium songaricum extract, 5-15 parts by weight of Epimedium extract, 5-15 parts by weight of Peppermint extract, 10-20 parts by weight of Peach Kernel extract, 10-20 parts by weight of Cyathula officinalis extract, 20-40 parts by weight of Patchouli extract, 20-40 parts by weight of Pumpkin Seed Extract, 3-8 parts by weight of Curcuma zedoaria extract, 3-8 parts by weight of Acorus calamus extract and 5-15 parts by weight of Curcuma longa extract.

[0023] In some embodiments of the present invention, the composition comprises: 30 parts by weight of Blumea balsamifera extract, 5 parts by weight of Herba Myrrhae extract, 20 parts by weight of Myrrha extract, 5 parts by weight of Camellia sinensis extract, 40 parts by weight of lemon extract, 20 parts by weight of Thyme extract, 5 parts by weight of Rosemary extract, 1 part by weight of Cistanche deserticola extract, 3 parts by weight of Cynomorium songaricum extract, 10 parts by weight of Epimedium extract, 10 parts by weight of Peppermint extract, 15 parts by weight of Peach Kernel extract, 15 parts by weight of Cyathula officinalis extract, 30 parts by weight of Patchouli extract, 30 parts by weight of Pumpkin Seed extract, 5 parts by weight of Curcuma zedoaria extract, 5 parts by weight of Acorus calamus extract and 10 parts by weight of Curcuma longa extract.

[0024] In some embodiments of the present invention, the composition is composed of: 30 parts by weight of Blumea balsamifera extract, 5 parts by weight of Herba Myrrhae extract, 20 parts by weight of Myrrha extract, 5 parts by weight of Camellia sinensis extract, 40 parts by weight of lemon extract, 20 parts by weight of Thyme extract, 5 parts by weight of Rosemary extract, 1 part by weight of Cistanche deserticola extract, 3 parts by weight of Cynomorium songaricum extract, 10 parts by weight of Epimedium extract, 10 parts by weight of Peppermint extract, 15 parts by weight of Peach Kernel extract, 15 parts by weight of Cyathula officinalis extract, 30 parts by weight of Patchouli extract, 30 parts by weight of Pumpkin Seed extract, 5 parts by weight of Curcuma zedoaria extract, 5 parts by weight of Acorus calamus extract and 10 parts by weight of Curcuma longa extract.

[0025] In some embodiments of the present invention, the composition is composed of: 30 parts by weight of Blumea balsamifera extract, 5 parts by weight of Herba Myrrhae Officinalis extract, 20 parts by weight of Myrrha Myrrha extract, 5 parts by weight of Camellia sinensis extract, 40 parts by weight of lemon extract, 20 parts by weight of Thyme extract, 5 parts by weight of Rosemary extract, 1 part by weight of Cistanche deserticola extract, 3 parts by weight of Cynomorium songaricum extract, 10 parts by weight of Epimedium extract, 10 parts by weight of Peppermint extract, 15 parts by weight of Peach Kernel extract, 15 parts by weight of Cyathula officinalis extract, 30 parts by weight of Patchouli extract, 30 parts by weight of Pumpkin Seed extract, 5 parts by weight of Curcuma zedoaria extract, 5 parts by weight of Acorus calamus extract, and 10 parts by weight of Curcuma longa extract;

[0026] The preparation method of the extract is as follows: taking the botanical material, crushing it, adding 3-7 times of its weight of a mixed solvent of n-hexane and ethyl acetate in a volume ratio of 3:1, standing at room temperature, filtering, and evaporating the filtrate to dryness to obtain the extract.

[0027] In some embodiments of the present invention, the composition is composed of: 30 parts by weight of Blumea balsamifera extract, 5 parts by weight of Herba Myrrhae Officinalis extract, 20 parts by weight of Myrrha Myrrha extract, 5 parts by weight of Camellia sinensis extract, 40 parts by weight of lemon extract, 20 parts by weight of Thyme extract, 5 parts by weight of Rosemary extract, 1 part by weight of Cistanche deserticola extract, 3 parts by weight of Cynomorium songaricum extract, 10 parts by weight of Epimedium extract, 10 parts by weight of Peppermint extract, 15 parts by weight of Peach Kernel extract, 15 parts by weight of Cyathula officinalis extract, 30 parts by weight of Patchouli extract, 30 parts by weight of Pumpkin Seed extract, 5 parts by weight of Curcuma zedoaria extract, 5 parts by weight of Acorus calamus extract, and 10 parts by weight of Curcuma longa extract;

[0028] The preparation method of the extract is as follows: take each of the botanical herbs, wash, dry, and crush, take 150 g, add 1 liter of a mixed solvent of n-hexane and ethyl acetate with a volume ratio of 3:1, stand at room temperature for 10 days, filter, and evaporate the filtrate under reduced pressure at 30 degrees Celsius to dryness to obtain the extract of the corresponding botanical herb.

[0029] In some embodiments of the present invention, the method for preparing the composition is as described in any one of Example 1. In some embodiments of the present invention, the method for preparing the composition is as described in Preparation Example 1 of Example 1.

[0030] In some embodiments of the present invention, the Blumea Balsamifera is the dried whole herb. In some embodiments of the present invention, the Herba Eupatorii is the dried whole herb. In some embodiments of the present invention, the Myrrha is the dried resin of the Herba Lycopodii. In some embodiments of the present invention, the Camellia Sinensis is the dried root. In some embodiments of the present invention, the Lemon is the dried fruit. In some embodiments of the present invention, the Thyme is the dried whole herb. In some embodiments of the present invention, the Rosemary is the dried whole herb. In some embodiments of the present invention, the Herba Cistanches is the dried fleshy stem with scaly leaves. In some embodiments of the present invention, the Herba Cynomorii songarici is the dried fleshy stem. In some embodiments of the present invention, the Herba Epimedii is the dried leaf. In some embodiments of the present invention, the Herba Mentha is the dried leaf. In some embodiments of the present invention, the Herba Pruni is the dried mature seed. In some embodiments of the present invention, the Herba Cynomorii is the dried root. In some embodiments of the present invention, the Herba Patchouli is the dried leaf. In some embodiments of the present invention, the Herba Cucurbitae is the dried mature seed. In some embodiments of the present invention, the Herba Curcumae is the dried rhizome. In some embodiments of the present invention, the Herba Acorus Tatarinowii is the dried rhizome of the Herba Lycopodii. In some embodiments of the present invention, the turmeric is a dried rhizome.

[0031] In another aspect of the present invention, a cream is provided, comprising the composition according to any one of the present invention.

[0032] In some embodiments of the present invention, the preparation method of the cream is: take 5 parts by weight of the composition of the present invention, mix it with 5-15 parts by weight of liquid paraffin, 40-50 parts by weight of deionized water, 3-8 parts by weight of glycerol, 20-40 parts by weight of white petrolatum, 2-6 parts by weight of glyceryl monostearate, and 1-3 parts by weight of Tween-80 under heating conditions, and cool it to obtain the cream.

[0033] In some embodiments of the present invention, the heating condition is heating to 75°C.

[0034] In some embodiments of the present invention, the preparation method of the cream is as follows: 5 parts by weight of the composition of the present invention is mixed with 10 parts by weight of liquid paraffin, 44 parts by weight of deionized water, 5 parts by weight of glycerol, 30 parts by weight of white vaseline, 4 parts by weight of glyceryl monostearate, and 2 parts by weight of Tween-80 under heating conditions of 75° C., and stirred until the mixture cools to room temperature to obtain the cream.

[0035] In some embodiments of the present invention, the preparation method of the cream is as follows: take 5 grams of the composition of the present invention, add 5 grams of liquid paraffin, mix evenly to obtain a mixture of the composition and liquid paraffin; take 44 grams of deionized water, add 5 grams of glycerol, heat to 75°C, and mix evenly; take 30 grams of white vaseline, 5 grams of liquid paraffin, 4 grams of glyceryl monostearate, and 2 grams of Tween-80, heat to 75°C, and stir to fully melt and evenly dissolve; then add the mixture of the composition and liquid paraffin, and stir quickly to obtain a semi-fluid emulsion; under high-speed stirring conditions of 600 rpm, slowly add the mixed solution of water and glycerol, stir at 75°C for 5 minutes to form a semi-fluid emulsion; and cool to room temperature after stirring to obtain the cream.

[0036] In some embodiments of the present invention, the composition is composed of: 20-40 parts by weight of Blumea balsamifera, 3-8 parts by weight of Herba Myrrhae, 10-30 parts by weight of Camellia sinensis, 30-50 parts by weight of lemon, 10-30 parts by weight of thyme, 3-8 parts by weight of rosemary, 0.5-2 parts by weight of Cistanche deserticola, 1-5 parts by weight of Cynomorium songaricum, 5-15 parts by weight of Epimedium, 5-15 parts by weight of mint, 10-20 parts by weight of peach kernel, 10-20 parts by weight of Cyathula officinalis, 20-40 parts by weight of Patchouli, 20-40 parts by weight of pumpkin seeds, 3-8 parts by weight of Curcuma zedoaria, 3-8 parts by weight of Acorus calamus, and 5-15 parts by weight of turmeric.

[0037] In some embodiments of the present invention, the composition is composed of: 30 parts by weight of Blumea balsamifera extract, 5 parts by weight of Herba Myrrhae Officinalis extract, 20 parts by weight of Myrrha Myrrha extract, 5 parts by weight of Camellia sinensis extract, 40 parts by weight of lemon extract, 20 parts by weight of Thyme extract, 5 parts by weight of Rosemary extract, 1 part by weight of Cistanche deserticola extract, 3 parts by weight of Cynomorium songaricum extract, 10 parts by weight of Epimedium extract, 10 parts by weight of Peppermint extract, 15 parts by weight of Peach Kernel extract, 15 parts by weight of Cyathula officinalis extract, 30 parts by weight of Patchouli extract, 30 parts by weight of Pumpkin Seed extract, 5 parts by weight of Curcuma zedoaria extract, 5 parts by weight of Acorus calamus extract, and 10 parts by weight of Curcuma longa extract;

[0038] The extract is prepared by washing, drying, and crushing each plant medicinal material, taking 150 g, adding 1 liter of a mixed solvent of n-hexane and ethyl acetate in a volume ratio of 3:1, standing at room temperature for 10 days, filtering, and evaporating the filtrate under reduced pressure at 30 degrees Celsius to obtain the extract of the corresponding plant medicinal material.

[0039] In another aspect of the present invention, a medicine is provided, comprising the composition according to any one of the present invention, or the cream according to any one of the present invention.

[0040] The drug is suitable for external use, particularly for application to the skin surface of the perineum or prostate region, to relieve prostate-related discomfort, treat prostatitis, or assist in improving lower urinary tract symptoms. The drug can be used alone or in combination with physical therapy equipment (such as a low-frequency resonance device or radiofrequency electromagnetic device) to enhance transdermal absorption and improve local tissue microcirculation, thereby achieving a more optimal synergistic therapeutic effect.

[0041] The drug can be further prepared into medicines, medical auxiliary products, external preparations, or traditional Chinese medicine external treatment products. Specific dosage forms include but are not limited to creams, ointments, gels, washes, patches, sprays, hot compress oils, etc. The selected dosage form can be optimized according to the usage scenario and needs.

[0042] In another aspect of the present invention, provided is the use of the composition according to any one of the present invention and the cream according to any one of the present invention in the preparation of a medicament for preventing or treating prostate diseases.

[0043] In another aspect of the present invention, there is provided use of the composition according to any one of the present invention and the cream according to any one of the present invention in the preparation of a medicament for preventing or treating prostate discomfort.

[0044] In another aspect of the present invention, provided is the use of the composition according to any one of the present invention and the cream according to any one of the present invention in preparing a medicament for preventing or treating prostatitis.

[0045] In some embodiments of the present invention, there is provided a use of the composition according to any one of the present invention in the preparation of a medicament for preventing or treating prostate discomfort.

[0046] In some embodiments of the present invention, there is provided use of the cream according to any one of the present invention in the preparation of a medicament for preventing or treating prostate discomfort.

[0047] In some embodiments of the present invention, there is provided a use of the composition according to any one of the present invention in the preparation of a medicament for treating prostate discomfort.

[0048] In some embodiments of the present invention, there is provided use of the cream according to any one of the present invention in the preparation of a medicament for treating prostate discomfort.

[0049] In some embodiments of the present invention, the prostate discomfort is selected from the group consisting of: prostatitis, weak and delayed urination, frequent urination at night, frequent and urgent urination, emergency, and scrotal moisture.

[0050] In some embodiments of the present invention, the prostate disorder is prostatitis.

[0051] In some embodiments of the present invention, there is provided use of any one of the compositions of the present invention in the preparation of a medicament for treating prostatitis.

[0052] In some embodiments of the present invention, there is provided use of the cream according to any one of the present invention in the preparation of a medicament for treating prostatitis.

[0053] In another aspect of the present invention, a combination is provided, comprising the cream according to any one of the present invention and a quantum resonator.

[0054] In another aspect of the present invention, there is provided use of a combination of the cream according to any one of the present invention and a quantum resonator in the preparation of a drug or medical device for preventing or treating prostate disease.

[0055] In some embodiments of the present invention, the quantum resonator is used to enhance the therapeutic effect of the cream.

[0056] In another aspect of the present invention, a method for preparing a cream is provided. The preparation method comprises the following steps: mixing 5 parts by weight of the composition of the present invention with 5-15 parts by weight of liquid paraffin, 40-50 parts by weight of deionized water, 3-8 parts by weight of glycerol, 20-40 parts by weight of white vaseline, 2-6 parts by weight of glyceryl monostearate, and 1-3 parts by weight of Tween-80 under heating conditions, and cooling the mixture to obtain the cream.

[0057] In some embodiments of the present invention, the preparation method of the cream is as follows: 5 parts by weight of the composition of the present invention is mixed with 10 parts by weight of liquid paraffin, 44 parts by weight of deionized water, 5 parts by weight of glycerol, 30 parts by weight of white vaseline, 4 parts by weight of glyceryl monostearate, and 2 parts by weight of Tween-80 under heating conditions of 75° C., and stirred until the mixture cools to room temperature to obtain the cream.

[0058] In some embodiments of the present invention, the preparation method of the cream is as follows: take 5 grams of the composition of the present invention, add 5 grams of liquid paraffin, mix evenly to obtain a mixture of the composition and liquid paraffin; take 44 grams of deionized water, add 5 grams of glycerol, heat to 75°C, and mix evenly; take 30 grams of white vaseline, 5 grams of liquid paraffin, 4 grams of glyceryl monostearate, and 2 grams of Tween-80, heat to 75°C, and stir to fully melt and evenly dissolve; then add the mixture of the composition and liquid paraffin, and stir quickly to obtain a semi-fluid emulsion; under high-speed stirring conditions of 600 rpm, slowly add the mixed solution of water and glycerol, stir at 75°C for 5 minutes to form a semi-fluid emulsion; and cool to room temperature after stirring to obtain the cream.

[0059] In some embodiments of the present invention, the method for preparing the composition is as described in any one of Example 1. In some embodiments of the present invention, the method for preparing the composition is as described in Preparation Example 1 of Example 1.

[0060] Without being bound by theory, tea trees contain compounds such as terpinen-4-ol, which can inhibit local prostate TNF-α and IL-10 expression, reducing prostate edema and exhibiting both antibacterial and immunomodulatory effects. Myrrh contains active ingredients such as bisabolol, which can significantly inhibit the production of inflammatory mediators such as NO and PGE2, regulate macrophage activity, and alleviate chronic inflammatory responses. Limonene acts on bacterial cell walls and biomembranes, disrupting their integrity and altering cell membrane permeability, leading to cell dysfunction and even death. Rosmarinic acid exhibits broad-spectrum antimicrobial activity against both bacteria and fungi, with significant inhibitory effects against Bacillus subtilis, Micrococcus luteus, Escherichia coli, Staphylococcus aureus, and Mycobacterium solani. Menthol in mint dilates local blood vessels and increases local temperature, promoting transdermal absorption and enhancing the absorption of active ingredients. Peach kernel has a strong blood circulation-activating and blood stasis-removing effect. Achyranthes bidentata (Cygnus radiata) regulates hormone levels and relieves urethral obstruction, preventing further exacerbation of prostatitis. Terpenes in patchouli possess potent anti-inflammatory activity, significantly inhibiting NF-κB activity and the expression of its mediator genes (TNF-α, IL-6, and IL-1β), while also significantly upregulating Nrf2 expression and activating antioxidant genes (NQO-1, GCLC, and HO-1). Unsaturated fatty acids and antioxidants in pumpkin seeds can inhibit inflammation. Curcuma zedoaria contains numerous chemical components, with volatile oils and curcuminoids as its primary active ingredients, exhibiting potent antitumor, anti-inflammatory, and antiviral effects. The volatile oil of Acorus calamus has a complex composition, with over 60 known components, primarily phenylpropanoids and terpenoids. Components in the volatile oil, such as asarone, possess potent anti-inflammatory properties. Turmeric contains numerous active ingredients, primarily curcumene, sesquiterpenoids, turmericone, and flavonoids, exhibiting broad-spectrum antibacterial, anti-inflammatory, expectorant, and anti-fibrotic effects.

[0061] In a non-limiting manner, the composition of the present invention may exert biological activity through multiple mechanisms: extracts of turmeric, zedoary, Acorus calamus, patchouli, thyme, etc. inhibit anti-inflammatory factors, and extracts of tea tree, rosemary, lemon, etc. are antibacterial; extracts of peach kernel, Cyathula, epimedium, zedoary, Cistanche deserticola, etc. promote blood circulation, dredge meridians, soften and disperse nodules; extracts of pumpkin seed, patchouli, menthol, Acorus calamus, etc. can promote diuresis and dehumidify, and improve microcirculation; extracts of rosemary, turmeric, menthol, zedoary, etc. can resist free radical oxidation and relieve pain.

[0062] The inventors have also found through experiments that applying the functional cream containing natural plant essential oil of the present invention to the skin of the prostate area externally and using a quantum resonance instrument in conjunction with resonance stimulation of the area can further improve the therapeutic effect.

[0063] The possible reasons are as follows:

[0064] (1) Promote transdermal absorption of active ingredients in creams. 7.2MHz electromagnetic waves belong to the radio frequency range and can generate weak electromagnetic disturbances on the surface of the skin, which can improve the skin permeability of the cream in the following ways: generating a dielectric oscillation effect in the skin stratum corneum, temporarily reducing the stratum corneum barrier; causing the skin microenvironment temperature to rise (radio frequency thermal effect), increasing capillary dilation and cell permeability; changing the potential distribution on the skin surface, forming a "carrier field" that is conducive to the smooth diffusion of fat-soluble active substances (such as terpenes and phenols) into the subcutaneous tissue. This type of transdermal promotion mechanism has been widely used in technologies such as radio frequency transdermal drug delivery, plasma skin channels, and non-invasive targeted delivery.

[0065] (2) Improve local microcirculation and lymphatic return. When the radio frequency signal acts on the skin of the perineum, it will generate slight warmth and dielectric vibration in the superficial tissue. The specific effects include: activating capillary movement, enhancing blood perfusion, and promoting the discharge of metabolic products; stimulating the activity of capillary lymphatic vessels, assisting in the removal of inflammatory mediators; and increasing the "concentration gradient" of the active ingredients in the essential oil in the local tissue, further driving them to diffuse into the prostate area. This has positive significance for chronic prostatitis with congestion, edema, and tissue stiffness in the prostate area.

[0066] (3) Provide targeted physical resonance stimulation to synergize drugs. The 7.2MHz frequency is close to the frequency doubling structure of some biological currents. Literature reports that it may: activate voltage-gated calcium channels (VGCCs) on cell membranes; interfere with cell signal transduction pathways (such as cAMP, Ca 2 + dependent pathways); enhance the biological effects of the plant active ingredients in the cream (such as anti-inflammatory pathways and antioxidant pathways); similar to bioresonance conditioning, it can assist tissues in restoring their structural functions.

[0067] (4) Forming a dual-pathway synergistic treatment model of "drug effect + field effect". On the basis of traditional topical cream, adding 7.2MHz radio frequency resonance field can form the following synergistic pathways, namely, drug effect pathway: Chinese herbal essential oils are absorbed through the skin and act on the prostate; field effect pathway: the resonance field stimulates the cell microenvironment, improves microcirculation and energy metabolism; synergistic effect: clinical symptoms such as anti-inflammatory, analgesia, and improvement of urination are more significant, especially suitable for chronic and refractory prostatitis.

[0068] The technical effects of the technical solution of the present invention include: significant efficacy, significantly alleviating prostate discomfort / prostatitis-related symptoms; very simple preparation method, low cost; safe, with few side effects; easy to use, and strong patient compliance. DETAILED DESCRIPTION

[0069] The present invention is further illustrated by way of examples below, but the present invention is not limited to the scope of the examples. Experimental methods in the following examples where specific conditions are not specified were performed according to conventional methods and conditions, or selected according to the product specifications.

[0070] The raw materials used in the following examples are: Blumea balsamifera (dried whole herb), Herba Myrrha (dried whole herb), Myrrha (dried resin of the Herba Lycopodii), Camellia sinensis (dried root), Lemon (dried fruit), Thyme (dried whole herb), Rosemary (dried whole herb), Cistanche deserticola (dried fleshy stem with scaly leaves), Cynomorium songaricum (dried fleshy stem), Epimedium (dried leaf), Mentha (dried leaf), Peach kernel (dried mature seed), Cyathula (dried root), Patchouli (dried leaf), Pumpkin seed (dried mature seed), Curcuma zedoaria (dried rhizome), Acorus calamus (dried rhizome of Acorus tatarinowii), and Turmeric (dried rhizome).

[0071] Example

[0072] Example 1: Preparation of the extract of the present invention

[0073] Wash, dry, and crush 150 g of Blumea balsamifera (dried whole herb). Add 1 liter of a mixed solvent of n-hexane and ethyl acetate (volume ratio 3:1) and let stand at room temperature for 10 days. Filter the mixture, and evaporate the filtrate to dryness under reduced pressure at 30 degrees Celsius to obtain Blumea balsamifera extract (quasi-essential oil, extracted with n-hexane and ethyl acetate).

[0074] The same method was used to prepare extracts of other medicinal herbs (quasi-essential oils, extracted with n-hexane-ethyl acetate). For example, 150 g of patchouli (dried leaves) was washed, air-dried, and ground. The mixture was added to 1 liter of a 3:1 hexane-ethyl acetate (volume ratio) solvent mixture and allowed to stand at room temperature for 10 days. The mixture was filtered, and the filtrate was evaporated to dryness under reduced pressure at 30°C to obtain the patchouli extract.

[0075] Preparation Example 1: Take 30 parts by weight of the above-mentioned Blumea balsamifera extract, 5 parts by weight of Herba Myrrhae extract, 20 parts by weight of Myrrha extract, 5 parts by weight of Camellia sinensis extract, 40 parts by weight of lemon extract, 20 parts by weight of Thyme extract, 5 parts by weight of Rosemary extract, 2 parts by weight of Cistanche deserticola extract, 3 parts by weight of Cynomorium songaricum extract, 10 parts by weight of Epimedium extract, 10 parts by weight of Peppermint extract, 15 parts by weight of Peach Kernel extract, 15 parts by weight of Cyathula officinalis extract, 30 parts by weight of Patchouli extract, 30 parts by weight of Pumpkin Seed Extract, 5 parts by weight of Curcuma zedoaria extract, 5 parts by weight of Acorus calamus extract, and 30 parts by weight of Curcuma longa extract, mix them evenly to obtain Composition 1 (oil).

[0076] Preparation Example 2: Take 30 parts by weight of the above-mentioned Blumea balsamifera extract, 5 parts by weight of Herba Myrrhae extract, 20 parts by weight of Myrrha extract, 5 parts by weight of Camellia sinensis extract, 40 parts by weight of lemon extract, 20 parts by weight of Thyme extract, 5 parts by weight of Rosemary extract, 2 parts by weight of Cistanche deserticola extract, 3 parts by weight of Cynomorium songaricum extract, and 10 parts by weight of Epimedium extract, mix them evenly to obtain Composition 2 (oil).

[0077] Preparation Example 3: Take 10 parts by weight of the above-mentioned peppermint extract, 15 parts by weight of peach kernel extract, 15 parts by weight of Cyathula capitata extract, 30 parts by weight of patchouli extract, 30 parts by weight of pumpkin seed extract, 5 parts by weight of Curcuma zedoaria extract, 5 parts by weight of Acorus calamus extract, and 30 parts by weight of turmeric extract, mix them evenly, and obtain composition 3 (oil).

[0078] Comparative Preparation Example 1:

[0079] Take 40 parts of borneol, 20 parts of lavender oil, 10 parts of lemon oil, 10 parts of herba sylvestris, 10 parts of myrrh, 3 parts of rosemary oil, 3 parts of tea tree oil, 3 parts of thyme, 3 parts of borneol, 0.1 part of Cistanche deserticola, 0.1 part of Epimedium, and 0.1 part of Cynomorium songaricum;

[0080] First, borneol, herb, myrrh, thyme, borneol, Cistanche deserticola, epimedium, and Cynomorium songaricum are dried; borneol, herb, myrrh, thyme, borneol, Cistanche deserticola, epimedium, and Cynomorium songaricum are distilled separately by distillation to prepare crude essential oils; the crude essential oils are subjected to supercritical carbon dioxide extraction (the crude essential oils are loaded into an extractor and heated to 42-48°C, the extraction flow rate is 21-24 L / h, the extraction pressure is 23 MPa, and the extraction time is 8 hours); the mixture of carbon dioxide and the extracted essential oil is input into a separator, reduced to normal pressure and then to room temperature, where the carbon dioxide is separated from the essential oil to obtain secondary essential oil; the secondary essential oils are then fractionated and added with lavender oil, lemon oil, rosemary oil, and tea tree oil, and mixed to obtain a natural compound essential oil, which is recorded as composition C1.

[0081] Example 2: Cream Preparation

[0082] Take 5 grams of any composition prepared as described in Example 1, add 5 grams of liquid paraffin, and mix well to obtain a mixture of the composition and liquid paraffin.

[0083] Take 44 grams of deionized water, add 5 grams of glycerol, heat to 75°C, and mix well.

[0084] 30 g of white vaseline, 5 g of liquid paraffin, 4 g of glyceryl monostearate, and 2 g of Tween-80 were heated to 75° C. and stirred to fully melt and uniformly dissolve. A mixture of the composition and liquid paraffin was then added and rapidly stirred to uniformly dissolve the mixture. Under high-speed stirring (600 rpm), a mixed solution of water and glycerol was slowly added and stirred at 75° C. for 5 minutes to form a milky white, semi-fluid emulsion. The mixture was then cooled to room temperature while stirring to form a stable cream.

[0085] 5 grams of the composition was replaced by an equal mass of liquid paraffin, and other procedures were the same to prepare a drug-free cream.

[0086] The creams were pale yellow to light brown semi-solids with a distinct aromatic, plant-based odor. The creams were uniform, free of stratification and foreign matter. After being stored at room temperature for one month, the creams showed no stratification or oil precipitation and could still be applied evenly.

[0087] Example 3: Functional testing

[0088] Healthy male SD rats weighing 275-283 g were raised in a conventional manner for 10 days and allowed to eat and drink freely every day.

[0089] Rats were then randomly divided into a blank control group, a model group, and each combination group, with 20 rats in each group. Under a sterile environment, rats were anesthetized with 10% chloral hydrate (350 mg / kg) via intraperitoneal injection. A midline abdominal incision was made through the skin and abdominal muscle layer to expose the bladder and bilateral seminal vesicles, thereby exposing the prostate. Except for the blank control group, which received an equal volume of saline, rats in the remaining groups received 0.1 ml of a 1% carrageenan solution in saline injected into the ventral lobe of the prostate to induce a nonbacterial prostatitis model. Following the injection, the incisions were sutured, disinfected with alcohol, and observed for recovery.

[0090] On the second day after the model was established, medication was initiated: the skin just below the prostate region of the rats was shaved; 0.5 g of the cream was applied to the shaved area (approximately 2 square centimeters); gentle massage was performed for 1 minute, avoiding licking, and the rats were immobilized for 15 minutes. The cream was then applied once daily for 30 consecutive days. Both the blank control group and the model group were treated with the drug-free cream prepared as described in Example 2. Each combination group was treated with the cream containing the corresponding composition prepared as described in Example 2.

[0091] Sixteen hours after the last drug administration, the rats were anesthetized, whole blood samples were collected through the abdominal aorta, and then they were euthanized, and prostate tissues were removed for subsequent testing.

[0092] The collected blood samples were placed at room temperature for 4 hours and then centrifuged to separate the serum for the detection of monocyte chemoattractant protein-1 (MCP-1) expression levels, which were quantitatively analyzed using enzyme-linked immunosorbent assay (ELISA).

[0093] The prostate tissues were fixed with 10% formaldehyde, dehydrated, embedded in paraffin and sectioned. They were stained with hematoxylin-eosin (HE) and the histomorphological changes were observed under a microscope.

[0094] The scoring criteria for glandular morphology are as follows: 2 points if the glandular epithelial single layer cell structure is intact and neatly arranged, the cells are columnar or cubic, and the glandular folds are obvious; 4 points if the glandular epithelium is slightly hyperplastic and damaged, and the glandular epithelial folds are reduced; 6 points if the epithelial cell structure is obviously destroyed, and the folds are greatly reduced or completely disappeared.

[0095] The scoring criteria for inflammatory cell infiltration were as follows: a small number of inflammatory cells were occasionally seen in the glandular cavity, 2 points; a moderate number of inflammatory cells were infiltrated, 4 points; a large number of inflammatory cells accumulated in the glandular cavity accompanied by congestion, 6 points.

[0096] The experimental results are shown in Tables 1 and 2. The data of each group are the average values of the animals in the group.

[0097] The glandular morphology score of the composition 1 group was much lower than that of the other groups, with statistically significant differences (P<0.01). The inflammatory cell infiltration score of the composition 1 group was much lower than that of the other groups, with statistically significant differences (P<0.05).

[0098] The expression level of MCP-1 in the composition 1 group was also much lower than that in the other groups, with statistically significant differences (P<0.05).

[0099] Previous studies have shown that MCP-1 expression is significantly elevated in the prostatic fluid of patients with chronic prostatitis. This experiment demonstrates that Composition 1 can significantly reduce the expression level of MCP-1 in model animals, thereby exerting its anti-inflammatory effect.

[0100] In addition, the combination of composition 2 and composition 3 showed a good synergistic effect, which brought an unexpected comprehensive therapeutic effect to composition 1. The overall results showed that composition 1 has a significant effect in improving the pathological state of prostatitis.

[0101] Histopathological observations also supported the above results: the prostate of rats in the model group showed obvious deformation, glandular shrinkage, reduced glandular epithelial folds, and local shedding and necrosis; while the group treated with composition 1 showed obvious recovery of glandular structure, intact epithelium, and clear fold structure.

[0102] Table 1. Prostate tissue pathology scores

[0103] Grouping Glandular morphology score Inflammatory cell infiltration Model Group 5.9 5.8 Composition 1 set 2.3 3.1 Composition 2 groups 4.6 4.9 Composition 3 groups 5.2 4.9 Composition C1 group 4.8 4.7

[0104] Table 2. Expression levels of MCP-1

[0105]

[0106]

[0107] Example 4: Animal experiment on the treatment of prostatitis using plant essential oil cream combined with quantum resonance instrument

[0108] In the experimental scheme shown in Example 3, an essential oil cream + resonance group was added. That is, after the cream was applied, the treatment probe was placed above the cream-covered area using a quantum resonance instrument, the resonance frequency was set to 7.2 MHz, and the action time was 10 minutes to ensure good local skin contact and avoid thermal damage.

[0109] Testing 15 days after administration revealed that the improvement achieved by the Composition 1 + Resonance group (15 days) was comparable to that achieved by Composition 1 in Example 3 (30 days), demonstrating that the combination of Composition 1 and the Quantum Resonance Instrument further enhances the therapeutic effect. The combined use of the plant essential oil cream and the Quantum Resonance Instrument significantly enhanced the therapeutic effect of the topical cream, improving prostate inflammation in the model animals, demonstrating a synergistic effect and unexpected technical benefits.

[0110] Although the embodiments of the present invention have been described above, it will be understood that the above embodiments are illustrative and do not constitute limitations on the present invention. Those skilled in the art may change, modify and alter the above embodiments within the scope of the present invention.

Claims

1. A composition, characterized in that The composition comprises: Artemisia balsamifera, Herba Myrrhae, Myrrha, Tea Tree, Lemon, Thyme, Rosemary, Cistanche deserticola, Cynomorium songaricum, Epimedium, Mint, Peach Kernel, Cyathula officinalis, Patchouli, Pumpkin Seed, Curcuma zedoaria, Acorus calamus and Turmeric.

2. A composition, characterized in that The composition comprises: 20-40 parts by weight of Blumea balsamifera, 3-8 parts by weight of Herba Myrrhae, 10-30 parts by weight of Myrrha, 3-8 parts by weight of Camellia sinensis, 30-50 parts by weight of lemon, 10-30 parts by weight of Thyme, 3-8 parts by weight of Rosemary, 0.5-2 parts by weight of Cistanche deserticola, 1-5 parts by weight of Cynomorium songaricum, 5-15 parts by weight of Epimedium, 5-15 parts by weight of Menthol, 10-20 parts by weight of Peach Kernel, 10-20 parts by weight of Cyathula, 20-40 parts by weight of Patchouli, 20-40 parts by weight of Pumpkin Seed, 3-8 parts by weight of Curcuma zedoaria, 3-8 parts by weight of Acorus calamus and 5-15 parts by weight of Curcuma longa.

3. A composition, characterized in that The composition comprises: 20-40 parts by weight of Blumea balsamifera extract, 3-8 parts by weight of Herba Myrrhae Officinalis extract, 10-30 parts by weight of Myrrha myrrh extract, 3-8 parts by weight of Camellia sinensis extract, 30-50 parts by weight of lemon extract, 10-30 parts by weight of Thyme extract, 3-8 parts by weight of Rosemary extract, 0.5-2 parts by weight of Cistanche deserticola extract, 1-5 parts by weight of Cynomorium songaricum extract, 5-15 parts by weight of Epimedium extract, 5-15 parts by weight of Peppermint extract, 10-20 parts by weight of Peach Kernel extract, 10-20 parts by weight of Cyathula officinalis extract, 20-40 parts by weight of Patchouli extract, 20-40 parts by weight of Pumpkin Seed Extract, 3-8 parts by weight of Curcuma zedoaria extract, 3-8 parts by weight of Acorus calamus extract and 5-15 parts by weight of Curcuma longa extract.

4. The composition according to claim 3, wherein The preparation method of the extract is as follows: taking the botanical material, crushing it, adding a mixed solvent of n-hexane and ethyl acetate in a volume ratio of 3:1, standing at room temperature, filtering, and evaporating the filtrate to dryness to obtain the extract.

5. A composition, characterized in that The composition comprises: 30 parts by weight of Blumea balsamifera extract, 5 parts by weight of Herba Myrrhae Officinalis extract, 20 parts by weight of Myrrha Myrrha extract, 5 parts by weight of Camellia sinensis extract, 40 parts by weight of lemon extract, 20 parts by weight of Thyme extract, 5 parts by weight of Rosemary extract, 1 part by weight of Cistanche deserticola extract, 3 parts by weight of Cynomorium songaricum extract, 10 parts by weight of Epimedium extract, 10 parts by weight of Mentha piperita extract, 15 parts by weight of Prunus persica extract, 15 parts by weight of Cyathula officinalis extract, 30 parts by weight of Patchouli extract, 30 parts by weight of Pumpkin Seed extract, 5 parts by weight of Curcuma zedoaria extract, 5 parts by weight of Acorus calamus extract, and 10 parts by weight of Curcuma longa extract; The preparation method of the extract is as follows: taking the botanical material, crushing it, adding 3-7 times of its weight of a mixed solvent of n-hexane and ethyl acetate in a volume ratio of 3:1, standing at room temperature, filtering, and evaporating the filtrate to dryness to obtain the extract.

6. A cream, characterized in that The cream comprises the composition according to any one of claims 1 to 5.

7. The cream according to claim 6, wherein The preparation method of the cream is as follows: 5 parts by weight of the composition according to any one of claims 1 to 5 are mixed with 5-15 parts by weight of liquid paraffin, 40-50 parts by weight of deionized water, 3-8 parts by weight of glycerol, 20-40 parts by weight of white vaseline, 2-6 parts by weight of glyceryl monostearate, and 1-3 parts by weight of Tween-80 under heating conditions, and the mixture is cooled to obtain the cream.

8. A drug, characterized in that The medicine comprises the composition according to any one of claims 1 to 5, or the cream according to any one of claims 6 to 7.

9. Use of the composition according to any one of claims 1 to 5, the cream according to any one of claims 6 to 7, and the combination of the cream according to any one of claims 6 to 7 and a quantum resonator in the preparation of a medicament for preventing or treating prostatitis.

10. A combination comprising the cream according to any one of claims 6 to 7, and a quantum resonator.

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