Method and apparatus for generating sound stimulation signals for tinnitus, testing and sound therapy system

Abstract

An embodiment of the present invention provides a method and device for generating a sound stimulation signal for tinnitus, a testing and sound therapy system, which relate to the field of medical technology. The method for generating a sound stimulation signal for tinnitus includes: obtaining desensitization test data obtained by a desensitization test on a subject at a test frequency point; wherein the desensitization test at each test frequency point uses a test sound with a corresponding frequency and a specified playback rhythm; based on the tinnitus condition of the subject, obtaining reference desensitization data matched with the subject; based on the desensitization test data and the reference desensitization data of the subject, determining an energy adjustment parameter of the subject, and the energy adjustment parameter at least includes: an energy adjustment value at the test frequency point; adjusting the sound energy of a preset sound stimulation signal according to the energy adjustment parameter of the subject to obtain a target sound stimulation signal matched with the subject. In the present invention, different personalized sound stimulation signals can be generated for subjects with different tinnitus conditions.

Description

Technical Field

[0001] The present invention relates to the field of medical technology, and particularly to a method and device for generating sound stimulation signals for tinnitus, as well as a testing and sound therapy system. Background Art

[0002] Tinnitus is a common auditory abnormality, characterized by the perception of sound in the absence of external sound stimulation, usually described as ringing, buzzing, hissing, or whistling in the ears or head, which can be intermittent, continuous, or recurrent; the degree of pain varies from person to person, including from slightly annoying to severely affecting the quality of life, and even leading to suicidal tendencies, etc. The causes of tinnitus include noise, hearing loss, ototoxic drugs, ear infections, and other neurological or cardiovascular diseases. The pathophysiological characteristics of tinnitus are complex, and it is generally believed that abnormal neural activities caused by changes in neural plasticity in the peripheral and central auditory nervous systems lead to the misperception of sound in the absence of actual auditory signals.

[0003] Although the pathogenesis of tinnitus has not been fully elucidated, more and more evidence indicates that tinnitus is not just a local auditory problem, but involves widespread central nervous system dysfunction. These dysfunctions include overexcitation of the auditory cortex, abnormal activation of the attention network, dysregulation of the default network, and the involvement of the limbic system. In addition, tinnitus patients often suffer from mood disorders such as anxiety and depression, suggesting dysfunction of brain regions related to emotion regulation.

[0004] Currently, the commonly used tinnitus treatment methods are mainly masking treatment and sound therapy, which can relieve tinnitus symptoms; however, these tinnitus treatment methods usually use the same fixed sound to stimulate patients. However, there are individual differences in the responses of different patients to sound stimulation, which will cause the treatment effects to vary greatly among different patients, resulting in some patients not being able to achieve good tinnitus treatment effects. Summary of the Invention

[0005] The object of the present invention is to provide a method and device for generating sound stimulation signals for tinnitus, as well as a testing and sound therapy system, which can determine energy adjustment parameters matching the tinnitus condition of a subject based on the desensitization test data of the subject and in combination with reference desensitization data matching the tinnitus condition of the subject, and then can adjust the energy of a preset sound stimulation signal based on the energy adjustment parameters to obtain a target sound stimulation signal adapted to the subject; thus, it can generate different personalized sound stimulation signals for subjects with different tinnitus conditions, so that subjects with different tinnitus conditions can all obtain better tinnitus treatment effects through the adapted sound stimulation signals.

[0006] To achieve the above object, the present invention provides a method for generating a sound stimulation signal for tinnitus, comprising: obtaining desensitization test data of a subject obtained through desensitization tests at test frequency points; wherein the number of the test frequency points is at least one, and the desensitization test for each test frequency point uses a test sound with a corresponding frequency and a specified playback rhythm; based on the tinnitus condition of the subject, obtaining reference desensitization data matched with the subject; based on the desensitization test data of the subject and the reference desensitization data, determining an energy adjustment parameter of the subject, the energy adjustment parameter at least including: an energy adjustment value of the test frequency point; adjusting the sound energy of a preset sound stimulation signal according to the energy adjustment parameter of the subject to obtain a target sound stimulation signal matched with the subject.

[0007] The present invention further provides a desensitization test system, comprising: a masking test module for obtaining the minimum masking threshold of a subject at test frequency points; the number of the test frequency points is at least one; a test tone generation module for generating a test sound used in the desensitization test of the subject at each test frequency point; the desensitization test for each test frequency point uses a test sound with a corresponding frequency, a loudness above the minimum masking threshold of the subject at this test frequency point, and a specified playback rhythm; a sound output device for playing the test sound of the desensitization test; a data acquisition module for acquiring the desensitization test data of the subject at each test frequency point; the desensitization test data of each test frequency point is used to indicate the tinnitus change of the subject after the corresponding desensitization test.

[0008] The present invention further provides a device for generating a sound stimulation signal for tinnitus, comprising: a first acquisition module for obtaining desensitization test data of a subject obtained through desensitization tests at test frequency points; a second acquisition module for obtaining the tinnitus condition of the subject; a data processing module communicatively connected to the first acquisition module and the second acquisition module respectively; the data processing module is configured to execute the method for generating a sound stimulation signal for tinnitus as described above.

[0009] The present invention further provides a sound therapy system for tinnitus, comprising: a central processing module and a sound output device; the central processing module is used for the method for generating a sound stimulation signal for tinnitus as described above to obtain a target sound stimulation signal for output to a subject; the central processing module is further used for controlling the sound output device to play a corresponding sound based on the target sound stimulation signal.

[0010] The present invention further provides a computer-readable storage medium, the computer-readable storage medium being a non-volatile storage medium or a non-transitory storage medium, on which a computer program is stored, and when the computer program is run by a processor, it executes the steps of the method for generating a sound stimulation signal for tinnitus as described above.

[0011] In one embodiment, obtaining the desensitization test data of the subject at the test frequency points through desensitization testing includes:

[0012] Selecting at least one preset frequency point from each of the preset frequency points as the test frequency point of the subject;

[0013] Collecting the minimum masking threshold of tinnitus of the subject at each of the test frequency points;

[0014] Adding a set value to the minimum masking threshold of tinnitus at each of the test frequency points as the loudness of the test sound at that test frequency point;

[0015] During the desensitization test at each of the test frequency points, playing the test sound corresponding to that test frequency point according to the specified playback rhythm; wherein the specified playback rhythm is within the range of 35 - 45 Hz;

[0016] Collecting the desensitization test data of the subject at each of the test frequency points, and the desensitization test data of each test frequency point is used to indicate the change in tinnitus of the subject after the corresponding desensitization test.

[0017] In one embodiment, when the subject undergoes desensitization testing, the test sound used has any one or more of the following characteristics:

[0018] The test sound is a narrowband sound or a pure tone corresponding to the frequency of the current test frequency point;

[0019] The loudness of the test sound is 5 - 15 dB higher than the minimum masking threshold of tinnitus of the subject at the corresponding test frequency point;

[0020] The specified playback rhythm of the test sound is 40 Hz.

[0021] In one embodiment, the desensitization test data includes a desensitization amplitude and a desensitization time.

[0022] In one embodiment, the desensitization test data further includes a desensitization score; the desensitization score is calculated and determined according to the desensitization amplitude and the desensitization time.

[0023] In one embodiment, selecting at least one preset frequency point from each of the preset frequency points as the test frequency point of the subject includes any one or more of the following:

[0024] According to the tinnitus frequency of the subject, selecting a preset frequency point that matches the tinnitus frequency as the test frequency point;

[0025] Selecting several preset frequency points near the tinnitus frequency of the subject as the test frequency points;

[0026] Select at least one preset frequency point from low frequency, medium frequency, and high frequency as the test frequency point.

[0027] In one embodiment, obtaining reference desensitization data matching the subject based on the tinnitus condition of the subject includes:

[0028] Obtain the reference desensitization data of the target group matching the subject from the pre-constructed desensitization database according to the tinnitus frequency;

[0029] Determining the energy regulation parameter of the subject based on the desensitization test data of the subject and the reference desensitization data includes:

[0030] Determine the energy regulation parameter of the subject based on the desensitization test data of the subject and the reference desensitization data of the target group at each preset frequency point.

[0031] In one embodiment, determining the energy regulation parameter of the subject based on the desensitization test data of the subject and the reference desensitization data of the target group at each preset frequency point includes:

[0032] Evaluate the desensitization test data of the subject at each preset frequency point according to the desensitization test data of the subject at each test frequency point and the reference desensitization data of the target group at each preset frequency point;

[0033] Obtain the desensitization test data of the subject at each frequency point within the set frequency range according to the desensitization test data of the subject at each preset frequency point, and the set frequency range includes all the preset frequency points;

[0034] Compare the desensitization test data of the subject at each frequency point within the set frequency range with the reference desensitization data of the target group at each frequency point within the set frequency range obtained based on the desensitization database, and obtain the energy regulation parameter of the subject, where the energy regulation parameter includes: the energy regulation value at each frequency point within the set frequency range.

[0035] In one embodiment, evaluating the desensitization test data of the subject at each preset frequency point according to the desensitization test data of the subject at each test frequency point and the reference desensitization data of the target group at each preset frequency point includes:

[0036] Obtain the reference desensitization data of the target group at each preset frequency point from the desensitization database, and the reference desensitization data includes a reference desensitization score;

[0037] For each of the preset frequency points except the test frequency point, based on the desensitization score of the subject at the test frequency point and the reference desensitization score of the target group at the preset frequency point, evaluate the desensitization score of the subject at each of the preset frequency points.

[0038] In one embodiment, after obtaining the reference desensitization data of the target group at each of the preset frequency points from the desensitization database, it further includes:

[0039] Obtain the desensitization score deviation between the subject and the target group at each of the test frequency points, where the desensitization score deviation is the difference between the desensitization score of the subject and the reference desensitization score of the target group;

[0040] After evaluating the desensitization score of the subject at each of the preset frequency points except the test frequency point, based on the desensitization score of the subject at the preset frequency point and the reference desensitization score of the target group at the preset frequency point, it further includes:

[0041] For each of the preset frequency points except the test frequency point, based on the desensitization score deviation between the subject and the target group at each of the test frequency points, adjust the evaluated desensitization score of the subject at each of the preset frequency points.

[0042] In one embodiment, comparing the desensitization test data of the subject at each frequency point within the set frequency range with the reference desensitization data of the target group at each frequency point within the set frequency range obtained from the desensitization database to obtain the energy regulation parameter of the subject includes:

[0043] Obtain the average desensitization score of the target group at each of the preset frequency points based on the desensitization database;

[0044] Based on the average desensitization score of the target group at each of the preset frequency points, obtain the reference desensitization score of the target group at each frequency point within the set frequency range;

[0045] Based on the desensitization score of the subject at each of the preset frequency points, obtain the desensitization score of the subject at each frequency point within the set frequency range;

[0046] Based on the desensitization score of the subject at each frequency point within the set frequency range and the reference desensitization score of the target group at each frequency point within the set frequency range, compare to obtain the score difference between the desensitization score of the subject and the reference desensitization score of the target group at each frequency point within the set frequency range;

[0047] Determine the energy adjustment parameter of the subject according to the scoring difference between the desensitization score of the subject at each frequency point and the average desensitization score of the target group; wherein, if the scoring difference is greater than the first set value, increase the sound energy value at the corresponding frequency point; if the scoring difference is lower than the second set value, decrease the energy value of the sound at the corresponding frequency point; wherein, the first set value is greater than or equal to 0, and the second set value is less than or equal to 0.

[0048] In one embodiment, obtaining the desensitization scores of the subject at each frequency point within the set frequency range based on the desensitization scores of the subject at each of the preset frequency points includes:

[0049] Based on the desensitization scores of the subject at each of the preset frequency points and the reference desensitization scores of the target group at the preset frequency points, and combining the first scoring weight of the subject and the second scoring weight of the target group, obtain the desensitization scores of the subject at each frequency point within the set frequency range.

[0050] In one embodiment, the process of constructing the desensitization database includes:

[0051] Collect desensitization test data of patients with different tinnitus frequencies at each preset frequency point; the desensitization test data includes desensitization time and desensitization amplitude;

[0052] According to the desensitization time and desensitization amplitude of each patient at each preset frequency point, calculate the desensitization score corresponding to each patient at each preset frequency point;

[0053] Store the tinnitus frequency, desensitization time, desensitization amplitude, and desensitization score of each preset frequency point of each collected patient.

[0054] In one embodiment, the desensitization score at each frequency point is the product of the corresponding desensitization amplitude and the desensitization time; or the desensitization score at each frequency point is the result obtained after normalizing or standardizing the product of the corresponding desensitization amplitude and the desensitization time.

[0055] In one embodiment, after obtaining the target stimulus sound, it further includes:

[0056] Modulate the target sound stimulus signal according to the specified playback rhythm to obtain the final output target sound stimulus signal; the specified playback rhythm is within the range of 35 - 45 Hz.

[0057] Through the method and device for generating sound stimulus signals for tinnitus provided by the present application, a sound signal with better desensitization effect can be customized for tinnitus patients. Description of the Drawings

[0058] Figure 1It is a specific flowchart of the method for generating a sound stimulation signal for tinnitus in the first embodiment of the present invention;

[0059] Figure 2 It is Figure 1 a specific flowchart of step 101 of the method for generating a sound stimulation signal for tinnitus in

[0060] Figure 3 It is Figure 1 a specific flowchart of step 103 of the method for generating a sound stimulation signal for tinnitus in

[0061] Figure 4 It is a schematic diagram of the frequency - desensitization score curve of a subject in an embodiment of the present application;

[0062] Figure 5 It is a schematic diagram of the frequency - desensitization score curve and the average score reference line of another subject in another embodiment of the present application. Detailed implementation manners

[0063] The following will describe each embodiment of the present invention in detail with reference to the accompanying drawings to more clearly understand the purpose, features, and advantages of the present invention. It should be understood that the embodiments shown in the drawings are not limitations on the scope of the present invention, but only to illustrate the essential spirit of the technical solution of the present invention.

[0064] In the following description, certain specific details are set forth for purposes of explaining various disclosed embodiments to provide a thorough understanding of the various disclosed embodiments. However, one or more of these specific details may be practiced without these specific details by those skilled in the relevant art. In other instances, well - known devices, structures, and techniques associated with the present application may not be shown or described in detail so as not to unnecessarily obscure the description of the embodiments.

[0065] Unless the context requires otherwise, throughout the specification and claims, the words "comprise" and its variants, such as "comprising" and "having", should be understood in an open, inclusive sense, i.e., should be interpreted as "including, but not limited to".

[0066] References to "one embodiment" or "an embodiment" throughout the specification mean that a particular feature, structure, or characteristic described in connection with the embodiment is included in at least one embodiment. Thus, appearances of "in one embodiment" or "in an embodiment" in various places throughout the specification are not necessarily all referring to the same embodiment. Additionally, the particular features, structures, or characteristics may be combined in any manner in one or more embodiments.

[0067] As used in this specification and the appended claims, the singular forms "a" and "the" include plural referents unless the context clearly dictates otherwise. It should be noted that the term "or" is generally used in its inclusive sense of "and / or" unless the context clearly dictates otherwise.

[0068] In the following description, in order to clearly show the structure and working mode of the present invention, many directional terms will be used for description. However, terms such as "front", "rear", "left", "right", "outer", "inner", "outward", "inward", "up", "down", etc. should be understood as convenient terms and should not be understood as limiting terms.

[0069] The first embodiment of the present invention relates to a method for generating a sound stimulation signal for tinnitus, which can be applied to a sound therapy system for tinnitus. The sound therapy system for tinnitus includes: a central processing module and a sound output device. The central processing module can be a conventional processor, a microcontroller, etc., and the sound output device can be a wearable earphone or a speaker. There can be wired or wireless communication between the central processing module and the sound output device. After the central processing module executes the sound stimulation signal generation method of this embodiment, it can generate a target sound stimulation signal adapted to the tinnitus condition of the subject, and control the sound output device to output a corresponding stimulation sound based on the target sound stimulation signal; further, before controlling the sound output device to output a corresponding stimulation sound, the target sound stimulation signal can be modulated with a specified playback rhythm, and the specified playback rhythm is within the range of 35 - 45 Hz, for example, a 40 Hz rhythm. Because the sound stimulation of 40 Hz can regulate brain nerve activity and can play a role in reducing tinnitus, and the target sound stimulation signal is related to the tinnitus condition of the subject, so that the finally output 40 Hz rhythm sound stimulation can be adapted to the individual situation of the subject to achieve a better treatment effect of tinnitus desensitization.

[0070] The specific process of the method for generating a sound stimulation signal for tinnitus in this embodiment is as Figure 1 shown.

[0071] Step 101, obtain the desensitization test data obtained by the subject through desensitization tests at test frequency points; wherein, the number of test frequency points is at least one, and the desensitization test at each test frequency point uses a test sound with a corresponding frequency and a specified playback rhythm.

[0072] Specifically, the central processing module first obtains the desensitization test data obtained by the subject through desensitization tests at test frequency points. The desensitization test data includes the result data of the desensitization tests of the subject at at least one test frequency point; in an example, please refer to Figure 2 , step 101 specifically includes:

[0073] Sub-step 1011: Select at least one preset frequency point from each of the preset frequency points as the test frequency point for the subject.

[0074] The preset frequencies can adopt multiple fixed frequencies commonly used in tinnitus tests. Specifically, they include frequency points with several octave relationships, as well as several common tinnitus frequency points. For example, they include: 125 Hz, 250 Hz, 500 Hz, 1000 Hz, 2000 Hz, 4000 Hz, 5000 Hz, 6000 Hz, 8000 Hz, 10000 Hz, 12000 Hz, these 12 fixed frequencies.

[0075] Specifically, the way to select at least one preset frequency point from each of the preset frequency points as the test frequency point for the subject can be any one or combination of the following:

[0076] According to the tinnitus frequency of the subject, select a preset frequency point that matches the tinnitus frequency as the test frequency point. The tinnitus frequency of the subject can be stored in advance in the memory of the tinnitus sound therapy system. Of course, it can also be measured immediately, and the measurement method can be the pure tone measurement method. Here, select a preset frequency point that matches the tinnitus frequency of the subject as the test frequency point. For example, select a preset frequency point that is the same as or has the smallest difference from the tinnitus frequency of the subject as the test frequency point.

[0077] Select several preset frequency points near the tinnitus frequency of the subject as the test frequency points. For example, if the tinnitus frequency of subject A is 800 Hz, then 800 Hz and several fixed frequencies near 800 Hz (such as the above 250 Hz, 500 Hz, 1000 Hz, and 2000 Hz) can be selected as the test frequency points.

[0078] Select at least one preset frequency point from low frequency, medium frequency, and high frequency as the test frequency points. For example, select these three preset frequency points: 250 Hz, 4000 Hz, and 10000 Hz as the test frequency points.

[0079] Among them, the number of test frequency points selected can be less than the number of preset frequency points, which can reduce the amount of desensitization data measurement and still ensure the relevance between the desensitization data and the patient. Selecting the test frequency points based on the tinnitus frequency of the subject can select more suitable test frequency points for the subject, and thus more accurate estimation results can be obtained subsequently. It should be noted that in some embodiments, all the preset frequency points can be selected as the test frequency points.

[0080] Sub-step 1012: Collect the minimum masking threshold of the subject's tinnitus at each test frequency point.

[0081] Sub-step 1013: Add a set value to the minimum masking threshold of tinnitus at each test frequency point as the loudness of the test sound at that test frequency point.

[0082] Sub-step 1014: When performing the desensitization test at each test frequency point, play the test sound corresponding to that test frequency point according to the specified playback rhythm; where the specified playback rhythm is within the range of 35 - 45 Hz.

[0083] Sub-step 1015: Collect the desensitization test data of the subject at each test frequency point, and the desensitization test data at each test frequency point is used to indicate the change in tinnitus of the subject after the corresponding desensitization test.

[0084] Specifically, after selecting the test frequency points, it is necessary to perform desensitization tests on the subject at each test frequency point to obtain the desensitization test data of the subject at each test frequency point. Taking a test frequency point K as an example, before the subject performs the desensitization test at the test frequency point K, first obtain the minimum masking threshold (MML) of the subject's tinnitus at the test frequency point K. The specific process is as follows: The audio signal generating device can generate test sound stimulation signals corresponding to different frequencies (including the test frequency point K), and based on the test sound stimulation signals, control the sound output device to generate a test sound with a specified playback rhythm corresponding to the test frequency point K. Thus, the audio signal generating device outputs the test sound stimulation signals to the sound output device to control the sound output device to output the test sound with the specified playback rhythm at the test frequency point K, and continuously increase the energy intensity of the narrowband sound (the test sound corresponding to the frequency) in steps of 2 dB. Each energy intensity is played for 1 second until the data acquisition device receives the confirmation signal input by the subject indicating that the tinnitus can just be covered. Then the current energy intensity is the minimum masking threshold of the subject at the test frequency point K. It should be noted that in this embodiment and subsequent embodiments, the specified playback rhythm is in the range of 35 - 45 Hz. Preferably, 40 Hz can be selected, or it can be increased or decreased based on the conditions of different subjects. After obtaining the minimum masking threshold of the subject's tinnitus at the test frequency point K, then use the loudness increased by a set value (such as 10 dB above the minimum masking threshold of tinnitus) at the test frequency point K of the subject to control the sound output device to play the test sound with the specified playback rhythm for a selectable set duration, such as 30 s, 50 s, 1 minute; and receive the value representing the percentage of the remaining intensity of the subject's tinnitus (i.e., the percentage of the remaining intensity of the tinnitus under the condition of sound stimulation) input by Patient A through the data acquisition device, as well as the desensitization time when the subject's tinnitus returns to the initial intensity input by the subject. The recording method of this desensitization time is as follows: After playing the test sound stimulation with a 40 Hz rhythm at the minimum masking threshold (MML) of the subject at the test frequency point K for the set duration, start timing and obtain how much tinnitus the subject currently has remaining; and when the data acquisition device receives the confirmation signal input by the subject indicating that the tinnitus has returned to the initial intensity, stop timing, and the timing duration is the desensitization time. Among them, the value representing the percentage of the remaining intensity of the subject's tinnitus input by the subject is the current remaining tinnitus intensity, and the desensitization amplitude can be calculated based on the current remaining tinnitus intensity. For example, if the current remaining tinnitus intensity is 30%, the desensitization amplitude is 70%. The data acquisition device can be a mobile phone, a tablet computer, etc. It can display a user interface where the user can input test data, and the user interface is also used to display treatment parameters, treatment effect feedback, etc.

[0085] From the above, the desensitization test data of the subject at the test frequency point K can be obtained. The desensitization test data indicates the change in tinnitus of the subject after desensitization corresponding to each test frequency point; similarly, the desensitization test data of the subject at all test frequency points can be obtained through the desensitization test; the desensitization test data includes: desensitization amplitude and desensitization time; further, the desensitization test data also includes: desensitization score, and the desensitization score is calculated and determined according to the desensitization amplitude and desensitization time. In some examples, the desensitization score for each frequency point is the product of the corresponding desensitization amplitude and desensitization time; for example, the desensitization score of the subject at a certain test frequency point is equal to the product of the desensitization time and desensitization amplitude of the subject at that test frequency point.

[0086] In some examples, the desensitization score for each frequency point is the result obtained after normalizing or standardizing the product of the corresponding desensitization amplitude and desensitization time. There are various ways of normalization, and the present application does not limit the specific way of normalization. For example, the specific way is: after obtaining the product of the desensitization amplitude and desensitization time of the subject at all test frequency points, calculate the average value (the median can also be selected) of the products at all these test frequency points, and then use the difference between the product of the desensitization amplitude and desensitization time at each test frequency point and the average value as the desensitization score at each test frequency point; alternatively, the difference can also be divided by the average value as the final desensitization score.

[0087] Step 102, based on the tinnitus condition of the subject, obtain reference desensitization data that matches the subject.

[0088] Specifically, reference desensitization data for different tinnitus conditions can be pre-stored, and subsequently, corresponding reference desensitization data can be obtained according to the tinnitus condition of the subject. For the matching conditions, various methods can be adopted. For example, if the tinnitus frequency of the subject is used to characterize the tinnitus condition of the subject, the corresponding reference desensitization data can be matched according to the tinnitus frequency of the subject. The tinnitus frequency of the subject can be pre-stored in the memory of the tinnitus sound therapy system in advance. Of course, it can also be measured immediately, and the measurement method is the pure tone measurement method. After the central processing module obtains the tinnitus frequency of the subject, according to the tinnitus frequency, the reference desensitization data matching the subject is obtained. For example, the memory of the tinnitus sound therapy system has pre-set the reference desensitization data corresponding to different tinnitus frequencies. For example, the conventional tinnitus frequency range is divided into several tinnitus frequency segments (such as low frequency, medium frequency, high frequency), and each tinnitus frequency segment has corresponding reference desensitization data. Thus, according to the tinnitus frequency segment where the tinnitus frequency of the subject is located, the reference desensitization data corresponding to the tinnitus frequency segment can be used as the reference desensitization data matching the subject. It should be noted that in this embodiment, the tinnitus frequency of the subject is used as an example to illustrate the tinnitus condition of the subject, and other parameters that can characterize the tinnitus condition of the subject can also be applied to the tinnitus sound stimulation signal generation method of this embodiment.

[0089] In some embodiments, a desensitization database is pre-constructed in the memory of the tinnitus sound therapy system or the server of the tinnitus sound therapy system. The construction process of the desensitization database includes:

[0090] Collect desensitization test data of patients with different tinnitus frequencies at each preset frequency point; the desensitization test data includes desensitization time and desensitization amplitude. The measurement method of the desensitization test data of each patient at the preset frequency point is similar to the specific method for performing desensitization test on the subject described above, and will not be elaborated here.

[0091] According to the desensitization time and desensitization amplitude of each patient at each preset frequency point, calculate the desensitization score corresponding to each patient at each preset frequency point; similarly, the desensitization score of the patient is calculated and determined according to the desensitization amplitude and desensitization time. In some examples, the desensitization score at each frequency point is the product of the corresponding desensitization amplitude and desensitization time; for example, the desensitization score of a patient at a certain preset frequency point is equal to the product of the desensitization time and desensitization amplitude of the subject at that preset frequency point.

[0092] In some examples, the desensitization score at each frequency point is the result obtained after normalizing or standardizing the product of the corresponding desensitization amplitude and desensitization time. The method of normalization or standardization is not limited. The specific method of normalization is, for example: after obtaining the product of the desensitization amplitude and desensitization time at all preset frequency points of the patient, calculate the average value of the products at all these preset frequency points, and then use the difference obtained by subtracting the average value from the product of the desensitization amplitude and desensitization time at each preset frequency point as the desensitization score at each preset frequency point; alternatively, the difference can also be divided by the average value as the final desensitization score.

[0093] Therefore, regarding the desensitization score, the product of the desensitization time and desensitization amplitude can be used. More preferably, the desensitization score is the data obtained after normalizing or standardizing the product of the desensitization time and desensitization amplitude; unless otherwise specified hereinafter, the desensitization score mentioned below refers to the value after normalizing the product of the desensitization time and desensitization amplitude.

[0094] Store the tinnitus frequency of each patient collected, the desensitization time and desensitization amplitude at each preset frequency point; further, store the desensitization score of each sample patient at each preset frequency point.

[0095] Based on the foregoing process, after storing the tinnitus frequency, desensitization time, desensitization amplitude, and desensitization score of each patient obtained (which can also not be stored in the database first and be obtained by calculation during subsequent use), a desensitization database is formed.

[0096] That is to say, the desensitization database includes the tinnitus frequency, desensitization time, desensitization amplitude, and desensitization score of multiple patients; the desensitization data of each patient includes the desensitization time and desensitization amplitude, where each patient in the desensitization database has a corresponding tinnitus frequency, and there can be one or more patients with different tinnitus frequencies. The tinnitus frequency of the patient can be measured by the patient through pure tone audiometry.

[0097] Furthermore, for each group of patients (including several patients) with a specific tinnitus frequency in the desensitization database, a frequency-desensitization score curve for the group of patients with that tinnitus frequency can be obtained by fitting based on the desensitization score data of the group of patients with that tinnitus frequency at each preset frequency point. This curve can also be understood as the correspondence between the frequency points and the desensitization scores. Thus, the desensitization scores of each group of patients with a specific tinnitus frequency at different frequency points can be obtained from the curve. Among them, a preset frequency range can be set in advance. The preset frequency range is a conventional tinnitus frequency range, including the above-mentioned preset frequency points, for example, from 125 Hz to 12,000 Hz. Thus, for each tinnitus frequency, the desensitization scores at different frequency points within the preset frequency range can be obtained; among them, within the preset frequency range, the desensitization score at the preset frequency point is the value measured previously, and the desensitization score at a non-preset frequency point is an estimated value obtained by fitting; these data can also be stored in the desensitization database.

[0098] As described above, when obtaining the reference desensitization data matching the subject, according to the tinnitus frequency of the subject, the reference desensitization data of the target group matching the subject can be obtained from the pre-constructed desensitization database. The target group matching the subject is the group of patients in the desensitization database with the same tinnitus frequency as the subject or belonging to the same tinnitus frequency band range. The reference desensitization data of the target group may include the desensitization time, desensitization amplitude, and desensitization score of each patient in the target group at each preset frequency point; preferably, the reference desensitization data of the target group is calculated based on the desensitization test data of each patient in the group at each preset frequency point. For example, the reference desensitization data at each preset frequency point is the average or median value of the desensitization test data of each patient in the target group at the corresponding preset frequency point; taking the desensitization score as an example, the reference desensitization score of the target group at each preset frequency point is the average or median value of the desensitization scores of each patient in the target group at that preset frequency point. It should be noted that the desensitization score of the subject is of the same type as the desensitization score of the patients in the target group, for example, both are the product of the desensitization time and the desensitization amplitude, or both are the product of the desensitization time and the desensitization amplitude after normalization processing.

[0099] As described above, the test process for new subjects is simplified, the data of existing patients in the desensitization database is fully utilized, the time for the desensitization test of the subject is reduced, and it is also convenient to improve the efficiency and accuracy of treating new subjects subsequently.

[0100] Step 103: Based on the desensitization test data and the reference desensitization data of the subject, determine the energy adjustment parameter of the subject. The energy adjustment parameter at least includes: the energy adjustment value at the test frequency point.

[0101] The reference desensitization data at least includes the reference desensitization data at each test frequency point. Thus, the desensitization test data of the subject at each test frequency point can be combined with the reference desensitization data at each test frequency point to determine the energy adjustment value of the subject at each test frequency point.

[0102] In some embodiments, if the reference desensitization data is the reference desensitization data of the target group matched with the subject obtained from the desensitization database, then based on the desensitization test data of the subject and the reference desensitization data of the target group at each preset frequency point, the energy adjustment parameter of the subject is determined. Please refer to Figure 3 , and this step specifically includes:

[0103] Sub-step 1031: Evaluate the desensitization test data of the subject at each preset frequency point according to the desensitization test data of the subject at each test frequency point and the reference desensitization data of the target group at each preset frequency point.

[0104] Specifically, obtain the reference desensitization data of the target group at each preset frequency point from the desensitization database. The reference desensitization data includes the reference desensitization score. Subsequently, for each preset frequency point except the test frequency point, based on the desensitization score of the subject at the preset frequency point and the reference desensitization score of the target group at the preset frequency point, evaluate the desensitization score of the subject at each preset frequency point. Here, the desensitization scores of the subject at each preset frequency point are used as the desensitization test data for illustration, but it is not limited thereto. Similar methods can also be used to evaluate the desensitization amplitude and desensitization time of the subject at each preset frequency point.

[0105] In the foregoing process, only the desensitization test of the subject was performed at the test frequency point, and the desensitization scores of the subject at each test frequency point were obtained. The reference desensitization scores of the target group matched with the subject at each preset frequency point were obtained from the desensitization database. The preset frequency points include the test frequency points, that is, the reference desensitization scores of the target group at each test frequency point were obtained.

[0106] For the preset frequency points where the subject has not undergone the desensitization test, the desensitization scores of these preset frequency points can be obtained by estimation. The specific method is as follows:

[0107] According to the desensitization scores of the subject and the target group at each test frequency point, obtain the target desensitization scores of the subject at each test frequency point. For example, at each test frequency point, calculate the average value of the desensitization score of the subject and the reference desensitization score of the target group as the target desensitization score.

[0108] In some embodiments, for each test frequency point, based on the reference desensitization score of the target group at the test frequency point and the first weight of the target group, as well as the desensitization score of the subject at the test frequency point and the second weight of the subject, the target desensitization score of the subject at each test frequency point is obtained. That is to say, a first weight (e.g., 0.3) is set for the target group, and a second weight (e.g., 0.7) is set for the subject; the sum of the first weight and the second weight is 1. At each test frequency point, calculate the product of the reference desensitization score of the target group and the first weight, and the product of the desensitization score of the subject and the second weight, and the sum of these two products can be used as the target desensitization score of the subject at the test frequency point; wherein, if the number of patients in the target group is multiple, the average value of the desensitization scores of all patients in the target group at the test frequency point, the product of the average value and the first weight, and the product of the desensitization score of the subject and the second weight are added together as the reference desensitization score of the subject at the test frequency point.

[0109] Subsequently, based on the target desensitization scores of the subject at each test frequency point, the desensitization scores of the subject at each preset frequency point other than the test frequency point among the multiple preset frequency points are obtained by interpolation; the interpolation method used can be Lagrange interpolation, cubic spline interpolation, etc., but is not limited thereto, and common interpolation methods can be used here.

[0110] Thus, the desensitization scores of the subject at all preset frequency points can be obtained.

[0111] In some embodiments, after obtaining the desensitization scores of the subject at all preset frequency points as described above, the desensitization scores at the preset frequency points other than the test frequency points can also be corrected. The specific correction method is as follows:

[0112] First, obtain the desensitization score deviation between the subject and the target group at each test frequency point. The desensitization score deviation is the difference between the desensitization score of the subject and the reference desensitization score of the target group.

[0113] For each preset frequency point except the test frequency points, based on the desensitization score deviation between the subject and the target group at each test frequency point, adjust the desensitization score of the evaluated subject at each preset frequency point. For example, the average deviation value of the desensitization score deviation between the subject and the target group at each test frequency point can be calculated, and then for the desensitization score of the evaluated subject at each preset frequency point (non-test frequency point), calculate the sum of the desensitization score at each preset frequency point (non-test frequency point) and the average deviation value to obtain the final desensitization score at each preset frequency point (non-test frequency point). Another example is that for the desensitization score of the evaluated subject at each preset frequency point (non-test frequency point), select the test frequency point closest to the preset frequency point, then obtain the desensitization score deviation at that test frequency point, and calculate the sum of the desensitization score at the preset frequency point and the desensitization score deviation at that test frequency point as the final desensitization score at that preset frequency point.

[0114] Sub-step 1032: According to the desensitization test data of the subject at each preset frequency point, obtain the desensitization test data of the subject at each frequency point within the set frequency range, and the set frequency range includes all preset frequency points.

[0115] Specifically, based on the desensitization scores of the subject at all preset frequency points, determine the desensitization scores of the subject at each frequency within the set frequency range. For example, based on the data of the desensitization scores of the subject at each preset frequency point, fit to obtain the frequency-desensitization score curve of the subject, and thus the desensitization scores of the subject at each frequency point within the set frequency range can be obtained from the curve. Among them, within the set frequency range, the desensitization score of the subject at the test frequency point is the value measured previously, the desensitization score at the preset frequency point of the non-test frequency point is the desensitization score obtained by the aforementioned interpolation method, and the desensitization score at the non-preset frequency point is the estimated value obtained by fitting.

[0116] In addition, when fitting the frequency-desensitization score curve of the subject based on the data of the desensitization scores of the subject at each preset frequency point, the desensitization scores of the subject at each preset frequency point used can all be the target desensitization scores of the subject at each preset frequency point; however, it is not limited to this. The measured desensitization score of the subject can be used at the test frequency point, and the target desensitization score of the subject can be used at the preset frequency point of the non-preset frequency point.

[0117] It should be noted that if the test frequency points include all the preset frequency points, for each preset frequency point, directly based on the desensitization score of the target population at the preset frequency point and the first weight of the target population, as well as the desensitization score of the subject at the preset frequency point and the second weight of the subject, the target desensitization score of the subject at the preset frequency point is obtained; then, the frequency-desensitization score curve of the subject is obtained by fitting the target desensitization scores of the subject at each preset frequency point, and the desensitization scores of the subject at each frequency point within the set frequency range can also be obtained from the curve.

[0118] Sub-step 1033: Compare the desensitization test data of the subject at each frequency point within the set frequency range with the reference desensitization data of the target population at each frequency point within the set frequency range obtained based on the desensitization database, to obtain the energy adjustment parameter of the subject. The energy adjustment parameter includes: the energy adjustment value at each frequency point within the set frequency range.

[0119] Specifically, based on the desensitization database, obtain the average desensitization score of the target population at each preset frequency point, and then based on the average desensitization scores of the target population at each preset frequency point, obtain the reference desensitization scores of the target population at each frequency point within the set frequency range; the target population may include one or more patients. After obtaining the desensitization scores of multiple patients in the target population at each preset frequency point, calculate the mean or median value of the desensitization scores of these patients at each preset frequency point respectively, to obtain the average desensitization score of the target population at each preset frequency point. Subsequently, based on the average desensitization scores of the target population at each preset frequency point, fit the frequency-desensitization score curve of the target population. This curve represents the desensitization scores of the target population at each frequency point within the set frequency range, that is, the reference desensitization scores at each frequency point.

[0120] Based on the desensitization scores of the subject at each preset frequency point, obtain the desensitization scores of the subject at each frequency point within the set frequency range; for example, fit the frequency-desensitization score curve of the subject based on the desensitization score data of the subject at each preset frequency point, and thus the desensitization scores of the subject at each frequency point within the set frequency range can be obtained from the curve.

[0121] In another embodiment, after obtaining the desensitization test data of the subject at each test frequency point, the desensitization test data includes desensitization scores; the desensitization scores of the subject at each test frequency point and the reference desensitization score data of the target population at each preset frequency point in the database can be jointly fitted, and the weights are reset at the same time. The setting of the weights can be determined according to the actual situation, and the specific values of the weight setting are not limited in this application. For example, the weight of the desensitization score data of the subject accounts for 30%, and the weight of the reference desensitization scores of the target population in the remaining database accounts for 70%. After such fitting, the frequency-desensitization score curve of the subject is obtained.Figure 4 As shown, the x-axis is the frequency and the y-axis is the desensitization score. The discrete data points represent the desensitization test scores of the subjects at the corresponding test frequency points (as previously described, the desensitization scores in the figure are the desensitization scores after normalization or standardization). The curve is the frequency-desensitization score curve of the subjects obtained by fitting; where k in 4k, 5k, 6k, 8k, 10k, and 12k represents 1000.

[0122] Specifically, for the preset frequency points that have not been tested, based on the desensitization scores of the subjects at each test frequency point, combined with the reference desensitization scores of the target group at each preset frequency point, the desensitization scores of the subjects at each preset frequency point other than the test frequency points can be evaluated by interpolation between frequencies; furthermore, based on the desensitization scores of the subjects at each preset frequency point and the reference desensitization scores of the target group at the preset frequency points, combined with the first scoring weight of the subjects and the second scoring weight of the target group, the desensitization scores of the subjects at each frequency point within the set frequency range can be obtained. For example, for each preset frequency point, according to the desensitization score of the target group at the preset frequency point and the first scoring weight of the target group, as well as the desensitization score of the subject at the preset frequency point and the second scoring weight of the subject, the reference desensitization scores of the subjects at each preset frequency point are obtained. That is to say, a first scoring weight (for example, 0.65) is set for the target group, and a second scoring weight (for example, 0.35) is set for the subjects; the sum of the first scoring weight and the second scoring weight is 1. At each preset frequency point, calculate the product of the reference desensitization score of the target group and the first scoring weight, and the product of the desensitization score of the subject and the second scoring weight, and adding these two products can be used as the reference desensitization score of the subject at the preset frequency point. Furthermore, based on the reference desensitization scores of the subjects at the preset frequency points, the frequency-desensitization score curve of the subjects can be obtained by fitting, and thus the desensitization scores of the subjects at each frequency point within the set frequency range can be obtained from the curve.

[0123] Based on the desensitization scores of the subjects at each frequency point within the set frequency range and the baseline desensitization scores of the target group at each frequency point within the set frequency range, the difference between the desensitization scores of the subjects and the average desensitization score of the target group at each frequency point within the set frequency range is obtained by comparison.

[0124] Determine the energy adjustment parameter of the subject according to the difference between the desensitization score of the subject at each frequency point and the average desensitization score of the target group;

[0125] Specifically, for each frequency point within the set frequency range, calculate the difference between the desensitization score of the subject at that frequency point and the baseline desensitization score of the target group at that frequency point to obtain the score difference at that frequency point. Thus, the score differences at each frequency point within the set frequency range can be obtained. Then, determine the energy adjustment parameter of the subject based on the difference between the desensitization score of the subject at each frequency point and the average desensitization score of the target group. Among them, for the frequency points corresponding to the score differences greater than the first difference threshold or less than the second difference threshold, they can be deleted and replaced with the score differences of adjacent frequency points (which need to be between the first difference threshold and the second difference threshold).

[0126] For each frequency point, if the score difference at that frequency point is greater than the first set value, increase the sound energy value at that frequency point. The energy adjustment value at that frequency point is the energy increase value (positive value). Based on this score difference, determine the magnitude of the energy increase value used to increase the energy at that frequency point. For example, a corresponding relationship between the score difference and the energy increase value is preset in advance. Based on this corresponding relationship, the energy increase value corresponding to the difference can be determined. The larger the difference, the larger the corresponding energy increase value. Another example is that multiple first difference intervals are preset in advance, and each first difference interval has a corresponding energy increase value. This energy increase value can be a fixed energy value, such as 2 dB, or a percentage value, such as 20%. Thus, based on the first difference interval to which the score difference belongs, the corresponding energy increase value can be determined. Among them, the first set value is greater than or equal to 0, and the first set value can be a positive value close to 0.

[0127] If the score difference at that frequency point is lower than the second set value, decrease the sound energy value at that frequency point. The energy adjustment value at that frequency point is the energy decrease value (negative value). For example, a corresponding relationship between the score difference and the energy decrease value is preset in advance. Based on this corresponding relationship, the energy decrease value corresponding to the score difference can be determined. The smaller the score difference, the larger the corresponding energy decrease value. Another example is that multiple second difference intervals are preset in advance, and each interval has a corresponding energy decrease value. This energy decrease value can be a fixed energy value, such as 2 dB, or a percentage value, such as 20%. Thus, based on the second difference interval to which the score difference belongs, the corresponding energy decrease value can be determined. Among them, the second set value is less than or equal to 0, and the second set value can be a negative value close to 0.

[0128] Specifically, such as Figure 5As shown, the x-axis represents frequency and the y-axis represents desensitization score. The discrete data points are the desensitization scores of another subject at the corresponding test frequency points. The blue curve in the figure is the fitted frequency-desensitization score curve of the subject, and the orange straight line is the average desensitization score reference line of the target group. If both the first set value and the second set value are 0, then in the frequency-desensitization score curve of this subject, the frequency segments above the average desensitization score reference line correspond to increasing the energy value of the sound (such as increasing by 1 - 5 dB), while for the frequency segments below the average desensitization score reference line, the energy value of the sound is correspondingly decreased (such as decreasing by 1 - 5 dB). In this way, the energy adjustment parameters for each frequency segment of this subject can be obtained. Here, k in 4k, 5k, 6k, 8k, 10k, and 12k represents 1000.

[0129] From the above, the energy adjustment parameters for each frequency within the set frequency range of the subject can be determined. The energy adjustment parameters of the subject include: the energy adjustment value for each frequency, and the energy adjustment value can be an energy increase value or an energy decrease value. Based on this, a curve of frequency - energy adjustment value (energy increase value or energy decrease value) can be fitted, which can be called the frequency-domain energy modulation curve of the subject, and the energy adjustment value corresponding to each frequency point can be obtained from this curve.

[0130] Step 104: Adjust the sound energy of the preset sound stimulation signal according to the energy adjustment parameters of the subject to obtain a target sound stimulation signal that matches the subject.

[0131] Step 103 includes: converting the preset sound stimulation signal into a sound frequency-domain signal, and using the energy adjustment values of the subject at each frequency point within the set frequency range to adjust the energy of the sound frequency-domain signal at each frequency point; converting the sound frequency-domain signal after energy adjustment to obtain the target sound stimulation signal.

[0132] Specifically, the preset sound stimulation signal is stored in the storage module of the tinnitus sound therapy system, which can be white noise, music, etc., or it can be an audio signal imported by the subject. Preferably, the preset sound stimulation signal is a broadband signal, and its frequency range at least includes the set frequency range, or it can only include the set frequency range.

[0133] The preset sound stimulation signal is a time-domain signal, with the horizontal axis representing time and the vertical axis representing energy values. First, perform a Fourier transform on the preset sound stimulation signal to convert it from the time domain to the frequency domain, obtaining a sound frequency-domain signal. The horizontal axis of the sound frequency-domain signal represents frequency, and the vertical axis represents energy values. Then, use the energy adjustment parameter of the subject, that is, the frequency-domain energy modulation curve of the subject, to adjust the energy values of each frequency point in the sound frequency-domain signal. Taking a frequency point P2 as an example, assume that the energy adjustment value of the frequency point P2 in the energy adjustment parameter is the energy increase value, and the energy increase value is 20%. If the energy value of the frequency point P2 in the sound frequency-domain signal is 20 db, then increase it by 20%. The adjusted energy value of the frequency point P2 is 20×1.2 = 24 db. Thus, for each frequency point in the sound frequency-domain signal, the energy value is adjusted correspondingly to obtain a sound frequency-domain signal after energy adjustment. Then, perform an inverse Fourier transform on this sound frequency-domain signal to convert it from the frequency domain to the time domain, obtaining the target sound stimulation signal.

[0134] During the above energy modulation process, the energy or amplitude of the preset sound stimulation signal at each frequency is modulated. For the frequency points with good desensitization effect on the subject, the energy values of the target sound stimulation signal at these frequency points are increased, making the change amplitude between the energy values of these frequency points and adjacent frequency points larger; for the frequency points with poor desensitization effect on the subject, the energy values of these frequency points are decreased, making the energy change amplitude between the energy values of these frequency points and adjacent frequency points smaller. Through this differential setting of energy modulation, stronger rhythmic stimulation can be applied in the frequency range sensitive to the subject, while the rhythmic stimulation is weakened in the frequency range insensitive to the subject, increasing the energy change amplitude and further improving the treatment effect of tinnitus desensitization.

[0135] Further, after step 104, it further includes:

[0136] Step 105, modulate the target sound stimulation signal according to the specified playback rhythm as the finally output target sound stimulation signal; the specified playback rhythm is within the range of 35 - 45 Hz.

[0137] Specifically, taking the specified playback rhythm within the range of 35 - 45 Hz as an example, with the specified playback rhythm being 40 Hz, the modulation period of the 40 Hz rhythm modulation is the time length of a complete "play - stop" cycle. For example, if it is set to 25 ms, then the control target sound stimulation signal is played according to the rhythm of playing for 12.5 ms and stopping for 12.5 ms; the specific method is, for example: superimposing a 40 Hz modulation signal (such as a square wave signal) on the target sound stimulation signal, the period of this signal is 25 ms, where the high level lasts for 12.5 ms and the low level lasts for 12.5 ms, that is, performing periodic modulation on the target sound stimulation signal, the modulation frequency = 1 / 25 ms = 40 Hz, that is, realizing 40 Hz rhythm modulation. During the high - level period of the modulation signal (square wave signal), the target sound stimulation signal is played, and during the low - level period, the target sound stimulation signal is muted.

[0138] That is to say, the central processing module controls the sound output device to play the target sound stimulation signal according to the 40 Hz rhythm. Thus, playing the target sound stimulation signal using the 40 Hz rhythm can effectively regulate the function of brain nerve activities and produce a better tinnitus desensitization effect on the subject.

[0139] In this embodiment, when the tinnitus sound therapy system treats the current user, the central processing module can control the sound output device to output the target sound stimulation signal according to the 40 Hz rhythm, and after each treatment ends, the treatment time reaches a certain duration or each treatment cycle ends, re - obtain the tinnitus frequency of the subject, and re - measure the desensitization score of the subject at each preset frequency point, and then repeat the above steps 101 to 104 to optimize and update the obtained target sound stimulation signal, so as to achieve a better treatment effect in subsequent tinnitus desensitization treatment. Through multiple optimizations, the best desensitization effect can be achieved. Further, the parameters can be further optimized according to the tinnitus THI scale, tinnitus visual analogue scale, and tinnitus loudness feedback by the subject. Specifically, if the subject feedbacks that the tinnitus treatment effect is good, the desensitization test data of this subject can be incorporated into the database, so that the energy regulation parameters obtained based on the desensitization database and the desensitization test data of new patients are more accurate and more conducive to the tinnitus treatment of new patients.

[0140] The second embodiment of the present invention relates to a desensitization test system for performing desensitization tests on subjects. The desensitization test system includes:

[0141] A masking test module for obtaining the minimum masking threshold of the subject at the test frequency point; the number of test frequency points is at least one;

[0142] A test tone generation module for generating test sounds used in desensitization tests for each test frequency point of the subject; the desensitization test for each test frequency point uses a test sound corresponding to the frequency, with a loudness above the minimum masking threshold of the subject at that test frequency point and a specified playback rhythm.

[0143] A sound output device for playing the test sounds of the desensitization test.

[0144] A data acquisition module for acquiring desensitization test data of the subject at each test frequency point; the desensitization test data for each test frequency point is used to indicate the tinnitus change of the subject after the corresponding desensitization test.

[0145] For the specific process of performing the desensitization test on the subject, reference can be made to the relevant content in the first embodiment, which will not be elaborated here.

[0146] The third embodiment of the present invention relates to a sound stimulation signal generation device for tinnitus, including:

[0147] A first acquisition module for obtaining desensitization test data obtained by the subject through desensitization tests at test frequency points.

[0148] A second acquisition module for obtaining the tinnitus situation of the subject, such as tinnitus frequency and / or tinnitus sound type, etc.

[0149] A data processing module is communicatively connected to the first acquisition module and the second acquisition module respectively; the data processing module is configured to execute the sound stimulation signal generation method for tinnitus in the first embodiment of the claims.

[0150] Since the first embodiment corresponds to this embodiment, this embodiment can be implemented in cooperation with the first embodiment. The relevant technical details mentioned in the first embodiment are still valid in this embodiment, and the technical effects achievable in the first embodiment can also be realized in this embodiment. To avoid repetition, they will not be elaborated here. Correspondingly, the relevant technical details mentioned in this embodiment can also be applied in the first embodiment.

[0151] The fourth embodiment of the present invention relates to a sound therapy system for tinnitus, including: a central processing module and a sound output device. The central processing module can be a conventional processor, a microcontroller, etc., and the sound output device can be a wearable earphone or a speaker. There can be wired or wireless communication between the central processing module and the sound output device.

[0152] The central processing module can execute the sound stimulation signal generation method of the first embodiment, generate a target sound stimulation signal adapted to the tinnitus condition of the subject, and control the sound output device to output a corresponding stimulation sound based on the target sound stimulation signal; further, before controlling the sound output device to output a corresponding stimulation sound, the target sound stimulation signal can be modulated with a specified playback rhythm, and the specified playback rhythm is within the range of 35-45 Hz, for example, it is a 40 Hz rhythm. Since the sound stimulation of 40 Hz can regulate brain nerve activities and can play a role in reducing tinnitus, and the target sound stimulation signal is related to the tinnitus desensitization parameter of the subject, so that the finally output sound stimulation of 40 Hz rhythm can be adapted to the individual situation of the subject to achieve a better treatment effect of tinnitus desensitization.

[0153] In some embodiments, the tinnitus sound therapy system further includes: an audio signal generating device and a data acquisition device; wherein:

[0154] The audio signal generating device is used to generate a test sound during the desensitization test of the subject at each test frequency point; the desensitization test at each test frequency point uses a test sound with a corresponding frequency, a loudness above the minimum masking threshold of the subject at the test frequency point, and a specified playback rhythm;

[0155] The sound output device is further used to play the test sound generated by the audio signal generating device;

[0156] The data acquisition device is used to collect the desensitization test data of the subject at each test frequency point; the desensitization test data at each test frequency point is used to indicate the tinnitus change of the subject after the corresponding desensitization test;

[0157] The data acquisition device is further used to collect the tinnitus condition of the subject; and transmit the desensitization test data of the subject at each test frequency point and the tinnitus condition of the subject to the central processing module.

[0158] Specifically, the audio signal generating device can generate the sound stimulation signals required for the desensitization test at multiple frequencies; the central processing module is used to execute the relevant steps of the desensitization test, including controlling the sound output device to play the test sound at the corresponding test frequency point according to the specified playback rhythm through the audio signal generating device.

[0159] The central processing module is further used to receive the desensitization test data of the subject at each test frequency and the tinnitus condition of the subject (such as tinnitus frequency) through the data acquisition device.

[0160] An audio signal generating device, a sound output device, and a data acquisition device form a data collection system, which can be used to collect desensitization data and tinnitus conditions of different patients on the one hand to form a desensitization database. On the other hand, after the desensitization database is established, it can also collect the desensitization data and tinnitus conditions of the subjects to provide a customized basis for the generation of the sound stimulation signals required for the tinnitus sound treatment of the subjects. The central processing module, the sound output device, and the data acquisition device form a stimulating sound synthesis system, which can generate target sound stimulation signals adapted to the subjects.

[0161] Since the first embodiment corresponds to this embodiment, this embodiment can be implemented in cooperation with the first embodiment. The relevant technical details mentioned in the first embodiment are still valid in this embodiment, and the technical effects achievable in the first embodiment can also be achieved in this embodiment. To avoid repetition, they will not be elaborated here. Correspondingly, the relevant technical details mentioned in this embodiment can also be applied to the first embodiment.

[0162] The fifth embodiment of the present invention relates to a computer-readable storage medium, which is a non-volatile storage medium or a non-transitory storage medium, on which a computer program is stored. When the computer program is run by a processor, it executes the steps of the method for generating a sound stimulation signal for tinnitus as in the first embodiment.

[0163] The preferred embodiments of the present invention have been described in detail above. However, it should be understood that if necessary, aspects of the embodiments can be modified to adopt aspects, features, and concepts of various patents, applications, and publications to provide additional embodiments.

[0164] In view of the detailed description above, these and other changes can be made to the embodiments. Generally speaking, in the claims, the terms used should not be construed as limited to the specific embodiments disclosed in the specification and the claims, but should be understood to include all possible embodiments together with the full equivalent scope enjoyed by these claims.

Claims

1. A method for generating a sound stimulation signal for tinnitus, characterized in that: include: Obtaining desensitization test data obtained by the subject through a desensitization test at a test frequency point; wherein the number of the test frequency point is at least one, and the desensitization test at each test frequency point uses a test sound with a corresponding frequency and a specified playback rhythm; According to the tinnitus frequency of the subject, obtaining reference desensitization data of a target group matching the subject from a pre-constructed desensitization database; According to the desensitization test data of the subject at each of the test frequency points and the reference desensitization data of the target group at each of the preset frequency points, evaluating the desensitization test data of the subject at each of the preset frequency points; According to the desensitization test data of the subject at each of the preset frequency points, obtaining the desensitization test data of the subject at each frequency point within a set frequency range, wherein the set frequency range includes all of the preset frequency points; Comparing the desensitization test data of the subject at each frequency point within the set frequency range with the reference desensitization data of the target group at each frequency point within the set frequency range obtained based on the desensitization database, to obtain the energy adjustment parameter of the subject, the energy adjustment parameter comprising: the energy adjustment value of each frequency point within the set frequency range; Adjusting the sound energy of a preset sound stimulation signal according to the energy adjustment parameter of the subject to obtain a target sound stimulation signal matching the subject; Wherein, comparing the desensitization test data of the subject at each frequency point within the set frequency range with the reference desensitization data of the target group at each frequency point within the set frequency range obtained based on the desensitization database to obtain the energy regulation parameter of the subject specifically includes: Obtaining an average desensitization score of the target group at each of the preset frequency points based on the desensitization database; Based on the average desensitization score of the target group at each of the preset frequency points, obtaining a baseline desensitization score of the target group at each frequency point within a set frequency range; Based on the desensitization score of the subject at each of the preset frequency points, obtaining the desensitization score of the subject at each frequency point within the set frequency range; Based on the desensitization score of the subject at each frequency point within the set frequency range and the baseline desensitization score of the target group at each frequency point within the set frequency range, a score difference between the desensitization score of the subject at each frequency point within the set frequency range and the baseline desensitization score of the target group is obtained by comparison; The energy regulation parameter of the subject is determined according to the score difference between the desensitization score of the subject at each frequency point and the average desensitization score of the target group; wherein, if the score difference is greater than a first set value, the sound energy value of the corresponding frequency point is increased; if the score difference is lower than a second set value, the energy value of the sound at the corresponding frequency point is reduced; wherein, the first set value is greater than or equal to 0, and the second set value is less than or equal to 0.

2. The method for generating a sound stimulation signal for tinnitus according to claim 1, characterized in that: The method of obtaining the desensitization test data obtained by the subject through the desensitization test at the test frequency point includes: Selecting at least one preset frequency point from each preset frequency point as a test frequency point of the subject; Collecting the minimum masking threshold of tinnitus of the subject at each of the test frequency points; Adding a set value to the minimum masking threshold of tinnitus at each test frequency point as the loudness of the test sound at the test frequency point; During the desensitization test at each test frequency point, the test sound corresponding to the test frequency point is played according to the specified playback rhythm; wherein the specified playback rhythm is within the range of 35-45 Hz; The desensitization test data of the subject at each of the test frequency points is collected, and the desensitization test data of each of the test frequency points is used to indicate the change of tinnitus of the subject after the corresponding desensitization test.

3. The method for generating a sound stimulation signal for tinnitus according to claim 1 or 2, characterized in that: The test sound used by the subject during the desensitization test has any one or more of the following characteristics: The test sound is a narrowband sound or a pure tone at a frequency corresponding to the current test frequency point; The loudness of the test sound is 5-15 dB above the minimum masking threshold of tinnitus of the subject at the corresponding test frequency point; The specified playing rhythm of the test sound is 40 Hz.

4. The method for generating a sound stimulation signal for tinnitus according to claim 1 or 2, characterized in that: The desensitization test data includes desensitization amplitude and desensitization time.

5. The method for generating a sound stimulation signal for tinnitus according to claim 4, characterized in that: The desensitization test data also includes a desensitization score; the desensitization score is calculated and determined based on the desensitization amplitude and the desensitization time.

6. The method for generating a sound stimulation signal for tinnitus according to claim 2, characterized in that: The selecting at least one preset frequency point from the preset frequency points as the test frequency point of the subject includes any one or more of the following: According to the tinnitus frequency of the subject, selecting a preset frequency point matching the tinnitus frequency as a test frequency point; Selecting several preset frequency points near the subject's tinnitus frequency as test frequency points; At least one preset frequency point is selected from each of the low frequency, the medium frequency and the high frequency as a test frequency point.

7. The method for generating a sound stimulation signal for tinnitus according to claim 1, characterized in that: The step of evaluating the desensitization test data of the subject at each of the preset frequency points according to the desensitization test data of the subject at each of the test frequency points and the reference desensitization data of the target group at each of the preset frequency points comprises: Acquire reference desensitization data of the target group at each of the preset frequency points from the desensitization database, wherein the reference desensitization data includes a reference desensitization score; For each of the preset frequency points except the test frequency point, based on the desensitization score of the subject at the test frequency point and the reference desensitization score of the target group at the preset frequency point, the desensitization score of the subject at each of the preset frequency points is evaluated.

8. The method for generating a sound stimulation signal for tinnitus according to claim 7, characterized in that: After obtaining the reference desensitization data of the target group at each of the preset frequency points from the desensitization database, the method further includes: Obtaining a desensitization score deviation between the subject and the target group at each test frequency point, the desensitization score deviation being a difference between the desensitization score of the subject and a reference desensitization score of the target group; After evaluating the desensitization score of the subject at each of the preset frequency points except the test frequency point based on the desensitization score of the subject at the preset frequency point and the reference desensitization score of the target group at the preset frequency point, the method further includes: For each of the preset frequency points except the test frequency point, the desensitization score of the assessed subject at each of the preset frequency points is adjusted based on the deviation of the desensitization score between the subject and the target group at each of the test frequency points.

9. The method for generating a sound stimulation signal for tinnitus according to claim 1, characterized in that: The step of obtaining the desensitization score of the subject at each frequency point within the set frequency range based on the desensitization score of the subject at each preset frequency point comprises: Based on the desensitization score of the subject at each of the preset frequency points and the reference desensitization score of the target group at the preset frequency point, combined with the first score weight of the subject and the second score weight of the target group, the desensitization score of the subject at each frequency point within the set frequency range is obtained.

10. The method for generating a sound stimulation signal for tinnitus according to claim 1, characterized in that: The construction process of the desensitization database includes: Collect desensitization test data of patients with different tinnitus frequencies at each preset frequency point; the desensitization test data includes desensitization time and desensitization amplitude; According to the desensitization time and desensitization amplitude of each patient at each preset frequency point, the desensitization score corresponding to each patient at each preset frequency point is calculated; The collected tinnitus frequency, desensitization time, desensitization amplitude, and desensitization score of each patient are stored.

11. The method for generating a sound stimulation signal for tinnitus according to claim 4, characterized in that: The desensitization score of each frequency point is the product of the corresponding desensitization amplitude and the desensitization time; or the desensitization score of each frequency point is the result obtained by normalizing or standardizing the product of the corresponding desensitization amplitude and the desensitization time.

12. The method for generating a sound stimulation signal for tinnitus according to claim 1, characterized in that: After obtaining the target sound stimulation signal, the method further includes: The target sound stimulation signal is modulated according to the specified playback rhythm to serve as the final output target sound stimulation signal; the specified playback rhythm is within the range of 35-45 Hz.

13. A device for generating a sound stimulation signal for tinnitus, characterized in that: include: The first acquisition module is used to obtain the desensitization test data obtained by the subject through the desensitization test at the test frequency point; A second acquisition module is used to obtain the tinnitus condition of the subject; A data processing module is respectively connected to the first acquisition module and the second acquisition module in communication; the data processing module is configured to execute the method for generating a sound stimulation signal for tinnitus according to any one of claims 1 to 12.

14. A sound treatment system for tinnitus, characterized in that: include: Central processing module and sound output device; The central processing module is used to execute the method for generating a sound stimulation signal for tinnitus according to any one of claims 1 to 12, to obtain a target sound stimulation signal for output to a subject; The central processing module is also used to control the sound output device to play corresponding sounds based on the target sound stimulation signal.

15. The sound treatment system for tinnitus according to claim 14, characterized in that: The acoustic treatment system for tinnitus also includes: an audio signal generating device and a data acquisition device; wherein: The audio signal generating device is used to generate a test sound for the subject during the desensitization test at each test frequency point; the desensitization test at each test frequency point uses a test sound of a corresponding frequency, a loudness above the minimum masking threshold of the subject at the test frequency point, and a specified playing rhythm; The sound output device is also used to play the test sound generated by the audio signal generating device; The data acquisition device is used to collect the desensitization test data of the subject at each test frequency point; the desensitization test data at each test frequency point is used to indicate the change of the tinnitus of the subject after the corresponding desensitization test; The data acquisition device is also used to collect the tinnitus condition of the subject; and transmit the desensitization test data of the subject at each test frequency point and the tinnitus condition of the subject to the central processing module.

16. A computer-readable storage medium, wherein the computer-readable storage medium is a non-volatile storage medium or a non-transient storage medium, and a computer program is stored thereon, wherein: When the computer program is executed by a processor, the steps of the method for generating a sound stimulation signal for tinnitus according to any one of claims 1 to 12 are executed.

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