Compound traditional Chinese medicine capsule for treating hypertension and preparation method thereof

Abstract

The invention relates to the technical field of traditional Chinese medicines, and particularly discloses a compound traditional Chinese medicine capsule for treating hypertension and a preparation method. Comprising 70 to 85 parts of pyrola calliantha, 45 to 60 parts of bidens pilosa, 45 to 54 parts of prunella vulgaris, 68 to 70 parts of radix clematidis, 75 to 81 parts of uncaria rhynchophylla, 40 to 52 parts of cape jasmine, 50 to 55 parts of coptis chinensis, 70 to 85 parts of schisandra chinensis, 58 to 66 parts of achyranthes bidentata, 75 to 80 parts of radix puerariae, 45 to 60 parts of semen raphani, 58 to 63 parts of beautiful sweetgum fruit, 10 to 13 parts of salvia miltiorrhiza, 12 to 14 parts of poria with hostwood, 16 to 18 parts of gastrodia elata and a plurality of additives. The internal environment of a patient is comprehensively conditioned, the effect of treating both symptoms and root causes is achieved, short-term decrease of blood pressure is not only concerned, the physical condition of the patient is fundamentally improved, and the possibility of blood pressure rebound is reduced.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a compound traditional Chinese medicine capsule for treating hypertension and a preparation method thereof. Background Art

[0002] As a common chronic disease, the incidence of hypertension is increasing year by year, which seriously threatens human health. At present, there are many kinds of drugs for the treatment of hypertension in clinical practice, including Western medicine and Chinese patent medicine. However, although Western medicine is effective in treating hypertension, it is often accompanied by certain side effects, such as dizziness, palpitations, dry cough, etc., and some patients are resistant to Western medicine, resulting in poor treatment effect.

[0003] Chinese patent medicines are gradually favored by patients in the treatment of hypertension because of their multi-component and multi-target characteristics, small side effects, stable efficacy, etc. However, existing Chinese patent medicines for the treatment of hypertension also have some problems, such as complex drug composition, cumbersome preparation process, and different efficacy. In addition, although some Chinese patent medicines can temporarily relieve symptoms, it is difficult to achieve the purpose of radical cure, and blood pressure is prone to rebound after stopping the drug. Therefore, a compound Chinese medicine capsule for the treatment of hypertension and a preparation method are proposed. Summary of the invention

[0004] The object of the present invention is to provide a compound Chinese medicine capsule for treating hypertension and a preparation method thereof, so as to solve the problems raised in the above-mentioned background technology.

[0005] To achieve the above object, the present invention provides the following technical solutions:

[0006] A compound Chinese medicine capsule for treating hypertension is composed of the following materials in parts by weight: 70-85 parts of deer vine, 45-60 parts of Bidens pilosa, 45-54 parts of Prunella vulgaris, 68-70 parts of Clematis chinensis, 75-81 parts of Uncaria rhynchophylla (without hook), 40-52 parts of Gardenia jasminoides, 50-55 parts of Coptis chinensis, 70-85 parts of Schisandra chinensis, 58-66 parts of Cyathula officinalis, 75-80 parts of Pueraria root, 45-60 parts of Radish seed, 58-63 parts of Scolopendra liquidambar formosana, 10-13 parts of Salvia miltiorrhiza, 12-14 parts of Poria, 16-18 parts of Gastrodia elata and several additives.

[0007] Preferably, the additives include 25-35 parts of Rhodiola rosea extract, 10-30 parts of nano-astragalus, 5-20 parts of kudzu flavonoids complex, 5-15 parts of selenium-enriched green tea extract, and 10-15 parts of coenzyme Q10 complex.

[0008] A method for preparing a compound Chinese medicine capsule for treating hypertension comprises the following steps:

[0009] S1. First alcohol extraction: Mix scutellaria baicalensis, Bidens pilosa, Prunella vulgaris, Clematis chinensis, Uncaria rhynchophylla, Gardenia jasminoides, Coptis chinensis, Schisandra chinensis, Achyranthes bidentata, Pueraria root, Radish seeds and Fructus liquidambar formosana evenly, soak them in 70% ethanol, with a solid-liquid ratio of 1:8, and the soaking time is 24 hours. After soaking, reflux extraction is performed, the extraction temperature is 75° C., and the extraction time is 2 hours. The extraction is repeated 3 times, and the extracts are combined and filtered to obtain the first alcohol extract;

[0010] S2, secondary alcohol extraction: Salvia miltiorrhiza, Poria and Gastrodia elata are mixed evenly, soaked in 80% ethanol, the solid-liquid ratio is 1:6, the soaking time is 12 hours, and reflux extraction is performed after soaking, the extraction temperature is 80°C, the extraction time is 1.5 hours, the extraction is repeated twice, the extracts are combined, and filtered to obtain a secondary alcohol extract;

[0011] S3, mixing and concentrating: the first alcohol extract and the second alcohol extract are mixed evenly, and concentrated using a rotary evaporator to 1 / 5 of the original volume to obtain a concentrated solution;

[0012] S4. Drying and preparation: Add Rhodiola rosea extract, nano-astragalus, kudzu flavonoids complex, selenium-enriched green tea extract and coenzyme Q10 complex to the concentrated solution, mix well, and dry in a vacuum drying oven at a drying temperature of 60°C for 12 hours to obtain a dried product. Crush the dried product and pass it through a 100-mesh sieve to obtain a powder. Put the powder into capsules, with each capsule containing 0.5 g, to obtain compound Chinese medicine capsules for treating hypertension.

[0013] Preferably, the preparation method of the nano-astragalus is:

[0014] A. Evenly mix the astragalus extract and the oil phase components, heat them, and at the same time, dissolve the surfactant and the water-soluble excipients in water, and also heat them to ensure that the surfactant is completely dissolved;

[0015] B. Under stirring conditions, slowly adding the heated water phase to the oil phase, stirring while adding, to form an emulsion, continuing to heat and stir the emulsion to gradually increase its temperature to the phase transition temperature (PIT), and then immediately cooling the emulsion to below the PIT, thereby obtaining nanoemulsion droplets with fine particle size;

[0016] C. Use a homogenizer to homogenize the cooled nanoemulsion to obtain nano-astragalus.

[0017] Preferably, the surfactant is a non-ionic surfactant containing polyoxyethylene, the oil phase is one of vegetable oil and mineral oil, and the water phase is a water-soluble auxiliary material.

[0018] Compared with the prior art, the present invention has the following beneficial effects:

[0019] (1) This formula has a good antihypertensive effect and also takes into account other symptoms or complications that may be caused by hypertension. Ingredients such as Salvia miltiorrhiza and Gastrodia elata have the effects of improving blood circulation and relieving headaches and dizziness; ingredients such as Coptis chinensis and Gardenia jasminoides have the effects of clearing away heat, purging fire, and detoxifying, which help improve the internal environment of patients with hypertension.

[0020] (2) By comprehensively regulating the patient's internal environment, we can achieve the effect of treating both the symptoms and the root causes, not just focusing on the short-term decrease in blood pressure, but fundamentally improving the patient's physical condition and reducing the possibility of blood pressure rebound. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 It is a process flow chart of the present invention. DETAILED DESCRIPTION

[0022] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0023] Embodiment 1:

[0024] See also Figure 1 As shown, a compound Chinese medicine capsule for treating hypertension is composed of the following materials in parts by weight: 80 parts of deer antlers, 60 parts of Bidens pilosa, 50 parts of Prunella vulgaris, 70 parts of Clematis chinensis, 80 parts of Uncaria rhynchophylla (clean hook), 50 parts of Gardenia jasminoides, 50 parts of Coptis chinensis, 80 parts of Schisandra chinensis, 60 parts of Achyranthes bidentata, 80 parts of Pueraria lobata, 60 parts of Radish seeds, 6 parts of Smilax glabra, 10 parts of Salvia miltiorrhiza, 12 parts of Poria, 16 parts of Gastrodia elata and some additives.

[0025] In one embodiment of the present invention, the additives include 25 parts of Rhodiola rosea extract, 10 parts of nano-astragalus, 5 parts of kudzu flavonoids complex, 5 parts of selenium-enriched green tea extract, and 10 parts of coenzyme Q10 complex.

[0026] A method for preparing a compound Chinese medicine capsule for treating hypertension comprises the following steps:

[0027] S1. First alcohol extraction: Mix scutellaria baicalensis, Bidens pilosa, Prunella vulgaris, Clematis chinensis, Uncaria rhynchophylla, Gardenia jasminoides, Coptis chinensis, Schisandra chinensis, Achyranthes bidentata, Pueraria root, Radish seeds and Fructus liquidambar formosana evenly, soak them in 70% ethanol, with a solid-liquid ratio of 1:8, and the soaking time is 24 hours. After soaking, reflux extraction is performed, the extraction temperature is 75° C., and the extraction time is 2 hours. The extraction is repeated 3 times, and the extracts are combined and filtered to obtain the first alcohol extract;

[0028] S2, secondary alcohol extraction: Salvia miltiorrhiza, Poria and Gastrodia elata are mixed evenly, soaked in 80% ethanol, the solid-liquid ratio is 1:6, the soaking time is 12 hours, and reflux extraction is performed after soaking, the extraction temperature is 80°C, the extraction time is 1.5 hours, the extraction is repeated twice, the extracts are combined, and filtered to obtain a secondary alcohol extract;

[0029] S3, mixing and concentrating: the first alcohol extract and the second alcohol extract are mixed evenly, and concentrated using a rotary evaporator to 1 / 5 of the original volume to obtain a concentrated solution;

[0030] S4. Drying and preparation: Add Rhodiola rosea extract, nano-astragalus, kudzu flavonoids complex, selenium-enriched green tea extract and coenzyme Q10 complex to the concentrated solution, mix well, and dry in a vacuum drying oven at a drying temperature of 60°C for 12 hours to obtain a dried product. Crush the dried product and pass it through a 100-mesh sieve to obtain a powder. Put the powder into capsules, with each capsule containing 0.5 g, to obtain compound Chinese medicine capsules for treating hypertension.

[0031] In one embodiment of the present invention, the preparation method of nano-astragalus is:

[0032] A. Evenly mix the astragalus extract and the oil phase components, heat them, and at the same time, dissolve the surfactant and the water-soluble excipients in water, and also heat them to ensure that the surfactant is completely dissolved;

[0033] B. Under stirring conditions, slowly adding the heated water phase to the oil phase, stirring while adding, to form an emulsion, continuing to heat and stir the emulsion to gradually increase its temperature to the phase transition temperature (PIT), and then immediately cooling the emulsion to below the PIT, thereby obtaining nanoemulsion droplets with fine particle size;

[0034] C. Use a homogenizer to homogenize the cooled nanoemulsion to obtain nano-astragalus.

[0035] In one embodiment of the present invention, the surfactant is a non-ionic surfactant containing polyoxyethylene, the oil phase is one of vegetable oil and mineral oil, and the water phase is a water-soluble auxiliary material.

[0036] Embodiment 2:

[0037] See also Figure 1 As shown, a compound Chinese medicine capsule for treating hypertension is composed of the following materials in parts by weight: 85 parts of deer antlers, 60 parts of Bidens pilosa, 54 parts of Prunella vulgaris, 68 parts of Clematis chinensis, 81 parts of Uncaria rhynchophylla (clean hook), 52 parts of Gardenia jasminoides, 55 parts of Coptis chinensis, 85 parts of Schisandra chinensis, 66 parts of Achyranthes bidentata, 75 parts of Pueraria lobata, 45 parts of Radish seeds, 63 parts of Smilax glabra, 13 parts of Salvia miltiorrhiza, 12 parts of Poria, 18 parts of Gastrodia elata and some additives.

[0038] In one embodiment of the present invention, the additives include 25-35 parts of Rhodiola rosea extract, 10 parts of nano-astragalus, 5 parts of kudzu flavonoids complex, 15 parts of selenium-enriched green tea extract, and 10 parts of coenzyme Q10 complex.

[0039] A method for preparing a compound Chinese medicine capsule for treating hypertension comprises the following steps:

[0040] S1. First alcohol extraction: Mix scutellaria baicalensis, Bidens pilosa, Prunella vulgaris, Clematis chinensis, Uncaria rhynchophylla, Gardenia jasminoides, Coptis chinensis, Schisandra chinensis, Achyranthes bidentata, Pueraria root, Radish seeds and Fructus liquidambar formosana evenly, soak them in 70% ethanol, with a solid-liquid ratio of 1:8, and the soaking time is 24 hours. After soaking, reflux extraction is performed, the extraction temperature is 75° C., and the extraction time is 2 hours. The extraction is repeated 3 times, and the extracts are combined and filtered to obtain the first alcohol extract;

[0041] S2, secondary alcohol extraction: Salvia miltiorrhiza, Poria and Gastrodia elata are mixed evenly, soaked in 80% ethanol, the solid-liquid ratio is 1:6, the soaking time is 12 hours, and reflux extraction is performed after soaking, the extraction temperature is 80°C, the extraction time is 1.5 hours, the extraction is repeated twice, the extracts are combined, and filtered to obtain a secondary alcohol extract;

[0042] S3, mixing and concentrating: the first alcohol extract and the second alcohol extract are mixed evenly, and concentrated using a rotary evaporator to 1 / 5 of the original volume to obtain a concentrated solution;

[0043] S4. Drying and preparation: Add Rhodiola rosea extract, nano-astragalus, kudzu flavonoids complex, selenium-enriched green tea extract and coenzyme Q10 complex to the concentrated solution, mix well, and dry in a vacuum drying oven at a drying temperature of 60°C for 12 hours to obtain a dried product. Crush the dried product and pass it through a 100-mesh sieve to obtain a powder. Put the powder into capsules, with each capsule containing 0.5 g, to obtain compound Chinese medicine capsules for treating hypertension.

[0044] In one embodiment of the present invention, the preparation method of nano-astragalus is:

[0045] A. Evenly mix the astragalus extract and the oil phase components, heat them, and at the same time, dissolve the surfactant and the water-soluble excipients in water, and also heat them to ensure that the surfactant is completely dissolved;

[0046] B. Under stirring conditions, slowly adding the heated water phase to the oil phase, stirring while adding, to form an emulsion, continuing to heat and stir the emulsion to gradually increase its temperature to the phase transition temperature (PIT), and then immediately cooling the emulsion to below the PIT, thereby obtaining nanoemulsion droplets with fine particle size;

[0047] C. Use a homogenizer to homogenize the cooled nanoemulsion to obtain nano-astragalus.

[0048] In one embodiment of the present invention, the surfactant is a non-ionic surfactant containing polyoxyethylene, the oil phase is one of vegetable oil and mineral oil, and the water phase is a water-soluble auxiliary material.

[0049] Experimental example:

[0050] One hundred patients with essential hypertension, aged 40-75 years old, half male and half female, were randomly divided into an experimental group and a control group, with 50 patients in each group.

[0051] Experimental methods:

[0052] Experimental group: Take compound Chinese medicine capsules daily, 2 capsules each time, 3 times a day, for 8 consecutive weeks;

[0053] Control group: taking placebo, which looks the same as the experimental group's medicine but does not contain active ingredients, and the method of taking and dosage are the same as the experimental group;

[0054] Detection indicators:

[0055] Blood pressure: Systolic and diastolic blood pressure were measured before the experiment, 4 weeks after the experiment, and 8 weeks after the experiment.

[0056] Safety indicators: blood routine, urine routine, liver and kidney function tests were performed before and after the experiment to evaluate drug safety;

[0057]

[0058]

[0059] There were no obvious abnormal changes in blood routine, urine routine, liver and kidney function in the experimental group and the control group before and after the experiment;

[0060] After continuous use for 8 weeks, this compound Chinese medicine capsule can significantly reduce the systolic and diastolic blood pressure of patients with hypertension, and has good safety, with no obvious adverse reactions observed.

[0061] In the present invention:

[0062] Deer Herb has the effects of clearing away heat and detoxifying, cooling blood and stopping bleeding. In the treatment of hypertension, it may play a role by regulating blood circulation and lowering blood pressure;

[0063] Bidens pilosa has the effects of clearing away heat and detoxifying, promoting blood circulation and removing blood stasis. It may help improve blood circulation, thus having a positive effect on high blood pressure;

[0064] Prunella vulgaris has the effects of clearing the liver and improving eyesight, dispersing nodules and reducing swelling. In the treatment of hypertension, it may assist in lowering blood pressure by regulating liver function and balancing hormones in the body;

[0065] Hardcore Clematis has the effects of dispelling wind and dampness, unblocking meridians and relieving pain. It may help improve blood circulation and relieve symptoms such as headaches caused by high blood pressure;

[0066] Uncaria rhynchophylla has the effects of calming the liver and extinguishing wind, relaxing muscles and activating collaterals. When treating hypertension, it may lower blood pressure by regulating liver function and soothing the tense nervous system;

[0067] Gardenia, which has the effects of purging fire and relieving restlessness, clearing heat and removing dampness. It may help relieve irritability and discomfort caused by high blood pressure;

[0068] Coptis chinensis has the effects of clearing away heat and dampness, purging fire and detoxifying. In the treatment of hypertension, it may assist in lowering blood pressure by clearing heat, toxins and dampness in the body;

[0069] Schisandra chinensis has the effects of astringing, strengthening qi and promoting body fluid, and nourishing the kidney and calming the mind. It may help regulate the balance of yin and yang in the body and enhance the body's immunity;

[0070] Achyranthes bidentata has the function of nourishing the liver and kidneys and strengthening the tendons and bones. When treating high blood pressure, it may help lower blood pressure by nourishing the liver and kidneys and enhancing body functions;

[0071] Pueraria root, which has the effects of relieving muscle and fever, promoting fluid and quenching thirst, and raising yang and stopping diarrhea. It may help improve blood circulation and lower blood pressure;

[0072] Radish seeds have the function of digesting food, relieving bloating, and reducing qi and phlegm. It may help improve digestive function and relieve symptoms such as chest tightness caused by high blood pressure;

[0073] Rhizoma Lulutong has the effects of dispelling wind, activating collaterals, promoting diuresis and dredging menstruation. In the treatment of hypertension, it may assist in lowering blood pressure by improving blood circulation and relieving blocked meridians;

[0074] Danshen, which has the effects of promoting blood circulation, removing blood stasis, promoting menstruation and relieving pain. It may help improve blood circulation and relieve symptoms such as pain caused by high blood pressure;

[0075] Poria root has the effects of calming the mind and promoting diuresis and removing dampness. It may help relieve symptoms such as anxiety and insomnia caused by high blood pressure;

[0076] Gastrodia elata has the effects of calming wind and stopping spasms, and calming liver yang. When treating hypertension, it may lower blood pressure by regulating liver function and soothing the tense nervous system;

[0077] Rhodiola rosea has the effects of invigorating qi and promoting blood circulation, relieving asthma and promoting blood circulation. It may help to enhance the body's endurance and adaptability, and have a positive impact on the treatment of hypertension;

[0078] Astragalus has the functions of replenishing Qi and raising Yang, strengthening the exterior and stopping sweating. Nano-processing may improve its bioavailability and effect, and help to assist in the treatment of hypertension;

[0079] Pueraria lobata flavonoids are one of the active ingredients in Pueraria lobata, which has antioxidant and anti-inflammatory effects. It may help protect blood vessels and lower blood pressure;

[0080] Selenium-enriched green tea is rich in selenium and antioxidants such as tea polyphenols, which help protect cardiovascular health and lower blood pressure;

[0081] Coenzyme Q10 is an important antioxidant that helps protect the cardiovascular system from oxidative damage, thereby having a positive impact on the treatment of hypertension.

[0082] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A compound Chinese medicine capsule for treating hypertension, characterized in that: The invention is composed of the following materials in parts by weight: 70-85 parts of deer vine, 45-60 parts of Bidens pilosa, 45-54 parts of Prunella vulgaris, 68-70 parts of Clematis chinensis, 75-81 parts of Uncaria rhynchophylla (without hook), 40-52 parts of Gardenia jasminoides, 50-55 parts of Coptis chinensis, 70-85 parts of Schisandra chinensis, 58-66 parts of Achyranthes bidentata, 75-80 parts of Pueraria root, 45-60 parts of Radish seed, 58-63 parts of Smilax glabra, 10-13 parts of Salvia miltiorrhiza, 12-14 parts of Poria, 16-18 parts of Gastrodia elata and some additives.

2. A compound Chinese medicine capsule for treating hypertension according to claim 1, characterized in that: The additives include 25-35 parts of rhodiola rosea extract, 10-30 parts of nano-astragalus, 5-20 parts of kudzu root flavonoids complex, 5-15 parts of selenium-enriched green tea extract, and 10-15 parts of coenzyme Q10 complex.

3. A method for preparing a compound Chinese medicine capsule for treating hypertension, characterized in that: The following steps are involved: S1. First alcohol extraction: Mix scutellaria baicalensis, Bidens pilosa, Prunella vulgaris, Clematis chinensis, Uncaria rhynchophylla, Gardenia jasminoides, Coptis chinensis, Schisandra chinensis, Achyranthes bidentata, Pueraria root, Radish seeds and Fructus liquidambar formosana evenly, soak them in 70% ethanol, with a solid-liquid ratio of 1:8, and the soaking time is 24 hours. After soaking, reflux extraction is performed, the extraction temperature is 75° C., and the extraction time is 2 hours. The extraction is repeated 3 times, and the extracts are combined and filtered to obtain the first alcohol extract; S2, secondary alcohol extraction: Salvia miltiorrhiza, Poria and Gastrodia elata are mixed evenly, soaked in 80% ethanol, the solid-liquid ratio is 1:6, the soaking time is 12 hours, and reflux extraction is performed after soaking, the extraction temperature is 80°C, the extraction time is 1.5 hours, the extraction is repeated twice, the extracts are combined, and filtered to obtain a secondary alcohol extract; S3, mixing and concentrating: the first alcohol extract and the second alcohol extract are mixed evenly, and concentrated using a rotary evaporator to 1 / 5 of the original volume to obtain a concentrated solution; S4. Drying and preparation: Add Rhodiola rosea extract, nano-astragalus, kudzu flavonoids complex, selenium-enriched green tea extract and coenzyme Q10 complex to the concentrated solution, mix well, and dry in a vacuum drying oven at a drying temperature of 60°C for 12 hours to obtain a dried product. Crush the dried product and pass it through a 100-mesh sieve to obtain a powder. Put the powder into capsules, with each capsule containing 0.5 g, to obtain compound Chinese medicine capsules for treating hypertension.

4. The method for preparing a compound Chinese medicine capsule for treating hypertension according to claim 3, characterized in that: The preparation method of the nano-astragalus is as follows: A. Evenly mix the astragalus extract and the oil phase components, heat them, and at the same time, dissolve the surfactant and the water-soluble excipients in water, and also heat them to ensure that the surfactant is completely dissolved; B. Under stirring conditions, slowly adding the heated water phase to the oil phase, stirring while adding, to form an emulsion, continuing to heat and stir the emulsion to gradually increase its temperature to the phase transition temperature (PIT), and then immediately cooling the emulsion to below the PIT, thereby obtaining nanoemulsion droplets with fine particle size; C. Use a homogenizer to homogenize the cooled nanoemulsion to obtain nano-sized Astragalus.

5. The method for preparing a compound Chinese medicine capsule for treating hypertension according to claim 4, characterized in that: The surfactant is a non-ionic surfactant containing polyoxyethylene, the oil phase is one of vegetable oil and mineral oil, and the water phase is a water-soluble auxiliary material.

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