Pure traditional Chinese medicine external preparation capable of treating fungal infection and preparation method thereof

Abstract

The invention discloses a pure traditional Chinese medicine external preparation capable of treating fungal infection and a preparation method thereof, and relates to the technical field of traditional Chinese medicine preparations, the pure traditional Chinese medicine external preparation is prepared from the following components: clove, peach leaf tincture, ligusticum wallichii tincture, cortex pseudolaricis, cortex phellodendri, cortex dictamni, radix sophorae flavescentis, fructus cnidii, dark plum, saponin, scutellaria baicalensis, houttuynia cordata, gallnut, dried alum, rhizoma coptidis from Sichuan of China, chaulmoogratree seed and lavender essential oil. The pure traditional Chinese medicine external preparation is prepared into the spray, medication is convenient, undesirable phenomena of medication discomfort, poor comfort and the like of traditional ointment are overcome, the spray is easily accepted by patients, the raw materials used by the pure traditional Chinese medicine external preparation are all natural Chinese herbal medicines, hormone-free and good in safety, and the pure traditional Chinese medicine external preparation does not generate obvious side effects of allergy and the like to the patients after long-time use, and is suitable for clinical application. The traditional Chinese medicine composition eliminates the drug resistance after the existing medicine is used, has a remarkable curative effect, is not easy to relapse after being cured, is sprayed on an affected part during use and is slightly massaged to be absorbed by the skin, and is safe and convenient to use.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicine preparations, and in particular to a pure traditional Chinese medicine external preparation capable of treating fungal infection and a preparation method thereof. Background Art

[0002] Diseases caused by fungal infections are called mycoses. Common fungal skin diseases are tinea manus, pedis and tinea, such as psoriasis, tinea manus and pedis, tinea versicolor, tinea cruris, bacterial skin infections, eczema and other skin diseases. They are highly contagious and difficult to cure. At present, the main topical drugs for the treatment of eczema-like skin diseases are glucocorticoids, immunosuppressants and some Chinese patent medicine preparations. These drugs may achieve good results in the early stage of treatment, but long-term use may cause certain side effects to users. Common side effects include itching, thinning of the skin, hair follicle atrophy, acne and even hormone-dependent dermatitis. Therefore, there is an urgent need for a pure Chinese medicine topical preparation for the treatment of fungal infections and its preparation method.

[0003] The existing technology has the following problems:

[0004] The treatment of fungal infection is mainly with topical and oral medications. In the prior art, the treatment is mostly carried out by applying Western medicine in the form of ointments to the affected area. However, Western antifungal drugs have large toxic side effects and drug resistance. Western medicine contains hormone ingredients, which have obvious effects within a short period of time after use, but will relapse after stopping the drug, and it is more difficult to treat after relapse. In addition, it is very inconvenient to apply topical medications, especially in summer, the comfort of topical ointment preparations is poor, and patients are not easy to accept. Summary of the invention

[0005] The present invention provides a pure Chinese medicine external preparation for treating fungal infection and a preparation method thereof, so as to solve the problems raised in the above background technology.

[0006] In order to solve the above technical problems, the technical solution adopted by the present invention is:

[0007] In a first aspect, the present invention provides a pure Chinese medicine external preparation for treating fungal infections. The pure Chinese medicine external preparation is made of the following components: clove, peach leaf tincture, chuanxiong tincture, tu jin pi xin, phellodendron chinense, dactylum bark, sophora flavescens, cnidium monnieri, ebony, sapodilla, scutellaria baicalensis, houttuynia cordata, gallnut, alum, chuan lian, da feng zi, and lavender essential oil.

[0008] Preferably, the dosage form of the pure Chinese medicine external preparation is a spray.

[0009] In a second aspect, the present invention further provides a method for preparing a pure Chinese medicine external preparation for treating fungal infection, the method for preparing the pure Chinese medicine external preparation comprising the following steps:

[0010] S1: weigh the raw materials according to the formula;

[0011] S2: grinding the medicinal materials into herbal powder and adding solvent to obtain an extract;

[0012] S3: filtration and purification;

[0013] S4: adding auxiliary materials and mixing to obtain a pure Chinese medicine external preparation;

[0014] S5: sterilize and fill to obtain the spray.

[0015] Preferably, the solvent is 50-75% ethanol.

[0016] Preferably, S2 comprises: putting the raw materials: clove, peach leaf tincture, chuanxiong tincture, radix scutellariae, phellodendron, cortex dactylis, sophora flavescens, fructus cnidii, ebony, sapodilla, scutellaria baicalensis, houttuynia cordata, gallnut, alum, and rhizoma chuanxiong into a grinder in proportion, starting the grinder to grind the raw materials into powder, then putting the herbal powder into a percolator, adding solvent to soak the medicinal materials, effectively dissolving the medicinal materials, extracting liquid from the lower part of the percolator from top to bottom, adding new solvent to the percolator at any time during the percolation process, so that the effective ingredients of the medicinal materials are fully leached to obtain the leachate, the soaking time is 2-5h, the percolation speed is 4-8ml / min, and the percolation time is 10-15h.

[0017] Preferably, S3 includes: after the leaching solution is allowed to stand for 25-35 minutes, adding it to a double-filter-type Chinese medicine multi-functional extraction tank, using the large-area annular filter screen of the tube body and the tank body drain port to obtain an extract with good drainage and complete filtration effect, heating and distilling the extract for purification to obtain a purified extract.

[0018] Preferably, S4 comprises: adding the purified pure Chinese medicine extract into a reaction tank, and adding deionized water and lavender essential oil, mixing and stirring evenly to obtain a blended medicine, and using activated carbon for adsorption and decolorization to obtain a pure Chinese medicine external preparation. The pure Chinese medicine external preparation prepared in this way can be used for the treatment of urticaria, eczema, fungal infection, fungal infection, tinea capitis, tinea corporis, tinea manuum, tinea versicolor, tinea cruris, athlete's foot, external auditory canal prurigo, senile skin itch, diabetic skin itch, sequelae of herpes zoster, folliculitis, acne, seborrheic dermatitis and the like.

[0019] Due to the adoption of the above technical solution, the present invention has the following technical advances compared with the prior art:

[0020] 1. The present invention provides a pure Chinese medicine external preparation for treating fungal infection and a preparation method thereof. The pure Chinese medicine external preparation is prepared from essential oils of clove, peach leaf tincture, chuanxiong rhizome tincture, tu jin pi, phellodendron, dactylum bark, sophora flavescens, cnidium monnieri, ebony, sapodilla, scutellaria baicalensis, houttuynia cordata, gallnut, alum, chuan lian, da feng zi and lavender. The pure Chinese medicine external preparation has the functions of relieving itching, relieving pain, reducing inflammation, killing bacteria and resisting allergy. The treatment pain of patients is small, and the preparation has a good therapeutic effect on fungal infected skin diseases, so that various eczema, fungal infection, allergy and unexplained skin itching, pain, chapped cracks and desquamation can be cured, and the preparation has a significant therapeutic effect on late epidermal neuralgia caused by herpes zoster. The preparation can be used by the elderly, the young and pregnant women, and has a wide range of application, and is suitable for use by all groups.

[0021] 2. The present invention provides a pure Chinese medicine external preparation for treating fungal infection and a preparation method thereof. The pure Chinese medicine external preparation is prepared into a spray, which is convenient to use and overcomes the adverse phenomena of traditional ointments such as discomfort and poor comfort. It is easy for patients to accept. The raw materials used in the pure Chinese medicine external preparation are all natural Chinese herbal medicines, without hormones, and have good safety. Long-term use will not cause obvious side effects such as allergies to patients, eliminates drug resistance after use of existing drugs, has significant efficacy, and is not prone to recurrence after cure. When used, it is sprayed on the affected area and gently massaged until absorbed by the skin. It is safe and convenient to use. Through the synergistic effect of each component, the pure Chinese medicine external preparation has good bactericidal, detoxifying and antipruritic effects, and has significant therapeutic effects on psoriasis, tinea manuum, tinea versicolor, tinea cruris, athlete's foot and neurodermatitis caused by various fungal infections.

[0022] 3. The present invention provides a pure Chinese herbal external preparation for treating fungal infection and a preparation method thereof. The pure Chinese herbal external preparation is prepared by processes such as crushing, extraction, filtering, and purification. The preparation process is simple, easy to operate, and has low production cost. 50-75% ethanol is used to extract the drug. The active ingredients extracted by this method have good transdermal absorption effect, which is beneficial to the skin absorption of the effective ingredients of the drug. Lavender essential oil is added to the raw materials for preparing the agent and can be used as a preservative. Lavender essential oil has antibacterial and antifungal effects, and can be assisted by bactericidal and antibacterial components of other Chinese herbal medicines to treat skin microorganisms, and the skin of the lesion site is well repaired. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 The present invention is a schematic diagram of the preparation process of the pure Chinese medicine external preparation. DETAILED DESCRIPTION

[0024] In order to make the technical means, creative features, objectives and effects achieved by the present invention easy to understand, the present invention is further explained below in conjunction with specific implementation methods.

[0025] In the first aspect, the present invention provides a pure Chinese medicine external preparation for treating fungal infections. The pure Chinese medicine external preparation is made of the following components: clove, peach leaf tincture, chuanxiong tincture, tuyinpi, phellodendron, difficile bark, sophora flavescens, cnidium monnieri, ebony, sapodilla, scutellaria baicalensis, houttuynia cordata, gallnut, alum, chuanxiong, zizyphus cyperus, and lavender essential oil.

[0026] Peach leaf tincture: It has the effects of dispelling wind and heat, drying dampness and detoxifying, and killing insects. It is used for eczema, carbuncle, ulcer, ringworm, malaria, etc.

[0027] Clove: It has the effects of anti-gastric ulcer, analgesia, antibacterial and insecticidal, and has inhibitory effects on a variety of pathogenic fungi, cocci, streptococci, pneumonia, dysentery, colon, typhoid and other bacteria, as well as influenza viruses;

[0028] Chuanxiong tincture: It has antibacterial, anti-inflammatory, blood-activating and analgesic effects, and can inhibit and eliminate a variety of skin fungi. It is used for skin fungal dermatitis, various psoriasis caused by fungal infections, eczema, athlete's foot, etc.

[0029] Tujinpi: It has antibacterial and antipruritic effects. It has different degrees of antibacterial effects on common pathogenic fungi. It is often used to treat stubborn ringworm, eczema, neurodermatitis and other diseases.

[0030] Huangbai: It has the effects of clearing away heat and dampness, purging fire and removing steam, detoxifying and curing sores. It is used for sores, swelling, eczema and itching.

[0031] Dictamni: It has the effects of clearing away heat and dampness, dispelling wind and detoxifying. It is used externally for eczema, scabies, skin itching, skin ulcers, yellow water dripping, etc. It has different degrees of inhibitory effects on various pathogenic fungi; Sophora flavescens: It has the effects of clearing away heat and dampness, and killing insects. It is used for swelling and itching of the vagina, eczema, wet sores, itchy skin, scabies, leprosy, tinea pedis, tinea manuum, fungal infection of skin diseases, etc.

[0032] Sophora flavescens: It has the effects of clearing away heat and dampness, antibacterial and anti-inflammatory, stomachic and antiparasitic, and is often used to treat skin itching;

[0033] Cnidium monnieri: It has the effects of clearing away heat and detoxifying, killing insects and relieving itching. It is often used for vaginal itching, eczema itching, dampness and low back pain, fungal infections such as skin infections;

[0034] Black plum: It has the effects of antibacterial, anti-protein allergy, anti-roundworm, anti-fatigue, anti-aging, anti-radiation, and enhancing immune function;

[0035] Gleditsia sinensis: It has certain antibacterial effects and can be used to treat cysts and other problems;

[0036] Scutellaria baicalensis: It has antibacterial and anti-inflammatory effects. It can treat skin allergic diseases such as urticaria, allergic dermatitis, and allergic purpura. It is also commonly used in the clinic to treat hypertension, urinary tract infection, pyelonephritis, prostatitis, and various inflammations of the skin and eyes.

[0037] Houttuynia cordata: It has antibacterial, antiviral, immunity-enhancing and diuretic effects. It can be used to treat snake and insect bites, female vulva itching, skin diseases and tinea pedis.

[0038] Chuanlian: It has the effects of clearing away heat and dampness, purging fire and detoxifying. It has certain therapeutic effects on stomach heat vomiting, thirst, carbuncle, ulcer, eczema, etc.

[0039] Fructus daphne: It has the functions of dispelling wind, attacking poison and killing insects, and can treat leprosy and scabies;

[0040] Drugs such as gallnut and alum have the effects of sterilization, antipruritic, moisture absorption and detoxification, and can be used for fungal infection of head skin diseases;

[0041] Lavender essential oil: has analgesic, anti-inflammatory, anti-rheumatic, antibacterial and bactericidal effects, and improves skin problems such as acne, blackheads, and acne caused by bacterial growth and clogged hair follicles.

[0042] The raw materials used in this pure Chinese medicine external preparation are all natural Chinese herbal medicines, without hormones, and have good safety. Long-term use will not cause obvious side effects such as allergies to patients. It eliminates drug resistance after the use of existing drugs, has significant therapeutic effects, and is not prone to recurrence after cure.

[0043] The scope of application of this pure Chinese medicine external preparation:

[0044] 1. Urticaria, UV allergy, drug allergy, food allergy, skin allergy itching after mosquito bites;

[0045] 2. Eczema, perianal eczema, vulvar eczema;

[0046] 3. Fungal infection, tinea capitis, tinea corporis, tinea manuum, tinea versicolor, tinea cruris, athlete's foot, prurigo of external auditory canal (for chapped fungal infection, applying zinc oxide ointment after topical medication will have better effect);

[0047] 4. Senile skin itching and diabetic skin itching;

[0048] 5. Special effects for post-herpetic sequelae (skin neuralgia, itching and various discomforts);

[0049] 6. Folliculitis, acne, seborrheic dermatitis, etc.

[0050] 7. It can effectively relieve itching and improve venous circulation in the lower limbs, and can treat skin itching and eczema caused by varicose veins in the lower limbs.

[0051] The dosage form of pure Chinese medicine external preparation is spray.

[0052] Pure Chinese herbal external preparations are prepared into sprays, which are convenient to use, overcome the adverse phenomena of traditional ointments such as discomfort and poor comfort, and are easily accepted by patients.

[0053] Second, as Figure 1 As shown, the present invention also provides a method for preparing a pure Chinese medicine external preparation for treating fungal infection, and the method for preparing the pure Chinese medicine external preparation comprises the following steps:

[0054] S1: weigh the raw materials according to the formula;

[0055] S2: grinding the medicinal materials into herbal powder and adding solvent to obtain an extract;

[0056] S3: filtration and purification;

[0057] S4: adding auxiliary materials and mixing to obtain a pure Chinese medicine external preparation;

[0058] S5: sterilize and fill to obtain the spray.

[0059] The solvent is 50-75% ethanol.

[0060] S2 comprises: putting the raw materials: clove, peach leaf tincture, chuanxiong tincture, radix scutellariae, phellodendron, cortex dactylis, sophora flavescens, fructus cnidii, ebony, sapodilla, scutellaria baicalensis, houttuynia cordata, gallnut, alum, and rhizoma chuanxiong into a grinder in proportion, starting the grinder to crush the raw materials into powder, then putting the herbal powder into a percolator, adding solvent to soak the medicinal materials, effectively dissolving the medicinal materials, extracting liquid from the lower part of the percolator from top to bottom, adding new solvent to the percolator at any time during the percolation process, so that the effective ingredients of the medicinal materials are fully leached to obtain the leachate, the soaking time is 2-5h, the percolation speed is 4-8ml / min, and the percolation time is 10-15h.

[0061] S3 includes: after the leaching solution is allowed to stand for 25-35 minutes, it is added into a double-filter-type Chinese medicine multi-functional extraction tank, and an extract with a fast and complete filtration effect is obtained by using a large-area annular filter screen on the tube body and a tank body discharge port, and the extract is heated and distilled for purification to obtain a purified extract.

[0062] S4 includes: adding the purified pure Chinese medicine extract into a reaction tank, and adding deionized water and lavender essential oil, mixing and stirring evenly to obtain a blended medicine, and using activated carbon for adsorption and decolorization to obtain a pure Chinese medicine external preparation. The pure Chinese medicine external preparation prepared in this way can be used for the treatment of urticaria, eczema, fungal infection, fungal infection, tinea capitis, tinea corporis, tinea manuum, tinea versicolor, tinea cruris, athlete's foot, external auditory canal prurigo, senile skin itch, diabetic skin itch, sequelae of herpes zoster, folliculitis, acne, seborrheic dermatitis and other symptoms.

[0063] The pure Chinese herbal external preparation is prepared by processes such as crushing, extraction, filtering, and purification. The preparation process is simple, easy to operate, and has low production cost. 50-75% ethanol is used to extract the drug. The active ingredients extracted by this method have good transdermal absorption effect, which is beneficial to the skin's absorption of the effective ingredients of the drug.

[0064] In summary, the raw materials are weighed according to the formula, and the raw materials: cloves, peach leaf tincture, Chuanxiong tincture, Tujinpi, Huangbai, Dictamni, Sophora flavescens, Cnidium monnieri, Wumei, Gleditsia sinensis, Scutellaria baicalensis, Houttuynia cordata, Gallnut, Alum, and Chuanlian are put into a grinder in proportion, and the grinder is started to crush the raw materials into powder. Subsequently, the herbal powder is put into a percolator, and 50-75% ethanol is added to soak the medicinal materials to effectively dissolve the medicinal materials. The percolator extracts the leaching liquid from the bottom of the percolator from top to bottom. During the percolation process, new 50-75% ethanol is added to the percolator at any time to fully extract the effective components of the medicinal materials to obtain the leaching liquid. The soaking time is 2-5h, the percolation speed is 4-8ml / min, and the percolation time is 10- 15h, 50-75% ethanol is used to extract the drug. The active ingredients extracted by this method have good transdermal absorption effect. After the leaching solution is allowed to stand for 25-35 minutes, it is added to a double-filter-type Chinese medicine multi-functional extraction tank. The large-area annular filter of the tube body and the tank body discharge port are used to obtain an extract with good rapid and complete filtration effect. The extract is heated and distilled for purification to obtain a purified extract. The purified pure Chinese medicine extract is added to a reaction tank, and deionized water and lavender essential oil are added. Lavender essential oil can be used as a preservative. After mixing and stirring evenly, a blended medicine is obtained. Activated carbon is used for adsorption and decolorization to obtain a pure Chinese medicine external preparation. After sterilization and filling, a pure Chinese medicine is obtained. The spray of the external preparation of Chinese medicine has a simple preparation process, is easy to operate, and has a low production cost. The pure Chinese medicine external preparation prepared thereby has the functions of relieving itching, relieving pain, reducing inflammation, sterilizing, and anti-allergic. The patient suffers little pain during treatment and has a good therapeutic effect on fungal skin diseases, thereby being able to cure various eczema, fungal infections, allergies, and unexplained skin itching, pain, chapped skin, and desquamation, and has a significant therapeutic effect on late-stage epidermal neuralgia caused by herpes zoster. The spray can be used by the elderly, children, and pregnant women, and is suitable for use by all groups. The pure Chinese medicine external preparation is prepared into a spray, which is convenient for medication, overcomes the adverse phenomena of traditional ointments such as discomfort and poor comfort, is easily accepted by patients, and is used The raw materials are all natural Chinese herbal medicines, hormone-free, and have good safety. Long-term use will not cause obvious side effects such as allergies to patients, eliminates drug resistance after use of existing drugs, has significant therapeutic effects, and is not prone to recurrence after cure. When used, spray it on the affected area and gently massage until absorbed by the skin. It is safe and convenient to use. Through the synergistic effect of various components, this pure Chinese medicine external preparation has excellent bactericidal, detoxifying and antipruritic effects, and has significant therapeutic effects on psoriasis, tinea manuum, tinea versicolor, tinea cruris, athlete's foot and various fungal infections of neurodermatitis. Lavender essential oil has antibacterial and antifungal effects, and can be supplemented with bactericidal and antibacterial components of other Chinese herbal medicines to treat skin microorganisms, and the skin of the lesion site is well repaired.

[0065] The above generally describes the present invention in detail, but it is obvious to a person skilled in the art that some modifications or improvements can be made to the present invention. Therefore, modifications or improvements that do not depart from the spirit of the present invention are within the scope of protection of the present invention.

Claims

1. A pure Chinese medicine external preparation for treating fungal infection, characterized in that: The pure Chinese medicine external preparation is prepared from the following components: clove, peach leaf tincture, chuanxiong tincture, tu jin pi jiang pi, phellodendron amurense, dactylum bark, sophora flavescens, cnidium monnieri, ebony, sapodilla, scutellaria baicalensis, houttuynia cordata, gallnut, alum, chuan lian, da feng zi and lavender essential oil.

2. A pure Chinese medicine external preparation for treating fungal infection according to claim 1, characterized in that: The dosage form of the pure Chinese medicine external preparation is a spray.

3. A method for preparing a pure Chinese herbal external preparation for treating fungal infections, comprising the pure Chinese herbal external preparation for treating fungal infections according to any one of claims 1 to 2, characterized in that: The preparation method of the pure Chinese medicine external preparation comprises the following steps: S1: weigh the raw materials according to the formula; S2: grinding the medicinal materials into herbal powder and adding solvent to obtain an extract; S3: filtration and purification; S4: adding auxiliary materials and mixing to obtain a pure Chinese medicine external preparation; S5: sterilize and fill to obtain the spray.

4. The method for preparing a pure Chinese medicine external preparation for treating fungal infection according to claim 3, characterized in that: The solvent is 50-75% ethanol.

5. The method for preparing a pure Chinese medicine external preparation for treating fungal infection according to claim 3, characterized in that: The S2 comprises: putting the raw materials: clove, peach leaf tincture, chuanxiong tincture, radix scutellariae, phellodendron, cortex dasyphyllae, sophora flavescens, fructus cnidium, ebony, sapodilla, scutellaria baicalensis, houttuynia cordata, gallnut, alum, and rhizoma chuanxiong into a grinder in proportion, starting the grinder to grind the raw materials into powder, then putting the herbal powder into a percolator, adding solvent to soak the medicinal materials, dissolving the effective ingredients of the medicinal materials, extracting liquid from the lower part of the percolator from top to bottom, adding new solvent to the percolator at any time during the percolation process, so that the effective ingredients of the medicinal materials are fully leached to obtain the leachate, the soaking time is 2-5h, the percolation speed is 4-8ml / min, and the percolation time is 10-15h.

6. The method for preparing a pure Chinese medicine external preparation for treating fungal infection according to claim 3, characterized in that: The step S3 comprises: after the leaching solution is allowed to stand for 25-35 minutes, adding the leaching solution into a double-filter-screen Chinese medicine multifunctional extraction tank, using the large-area annular filter screen of the tube body and the tank body discharge port to obtain an extract with good rapid and complete filtration effect, heating and distilling the extract to purify it, and obtaining a purified extract.

7. The method for preparing a pure Chinese medicine external preparation for treating fungal infection according to claim 3, characterized in that: The S4 comprises: adding the purified pure Chinese medicine extract into a reaction tank, and adding deionized water and lavender essential oil, mixing and stirring evenly to obtain a blended medicine, and using activated carbon for adsorption and decolorization to obtain a pure Chinese medicine external preparation. The pure Chinese medicine external preparation prepared in this way can be used for the treatment of urticaria, eczema, fungal infection, fungal infection, tinea capitis, tinea corporis, tinea manuum, tinea versicolor, tinea cruris, athlete's foot, prurigo of the external auditory canal, senile skin itching, diabetic skin itching, sequelae of herpes zoster, folliculitis, acne, seborrheic dermatitis and the like.

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