A compound component for treating Alzheimer's disease and anti-aging and its preparation method

Abstract

The present invention provides a compound component for treating Alzheimer's disease and anti-aging and a preparation method thereof, which relates to the technical field of pharmaceutical preparation. The compound component is mainly composed of six raw medicinal materials, namely ginger extract, cistanche deserticola extract, salvia miltiorrhiza extract, ganoderma lucidum extract, polygonatum sibiricum extract, and licorice extract. The weight parts of each component are as follows: 10-20 parts of ginger extract, 20-40 parts of cistanche deserticola extract, 10-15 parts of salvia miltiorrhiza extract, 15-30 parts of ganoderma lucidum extract, 5-10 parts of polygonatum sibiricum extract, 3-5 parts of licorice extract, and 5-10 parts of surfactant. In the present invention, the compound component can play a therapeutic role through multiple mechanisms, including antioxidant, anti-inflammatory, neuroprotective, immunomodulatory, etc. The compound component uses natural drug components, has high safety and small side effects, can significantly improve cognitive function and enhance memory. At the same time, the compound component has an anti-aging effect and can delay the aging process of the body.

Description

Technical Field

[0001] The present invention relates to the technical field of pharmaceutical preparation, and specifically relates to a compound component for treating Alzheimer's disease and anti-aging and a preparation method thereof. Background Art

[0002] Alzheimer's Disease (AD) is a common neurodegenerative disease, mainly manifested as symptoms such as cognitive decline, memory loss, language disorders, and behavioral abnormalities. With the aggravation of global aging, the incidence of Alzheimer's disease has been increasing year by year and has become one of the main factors affecting the quality of life of the elderly.

[0003] At present, the etiology and pathogenesis of Alzheimer's disease have not been fully elucidated and are mainly related to multiple factors such as β-amyloid (Aβ) deposition, neurofibrillary tangles, oxidative stress, and neuroinflammation. Aging is a complex physiological process and is closely related to the occurrence of various chronic diseases. As people age, the body's immune function, metabolic function, and antioxidant capacity gradually decline, making it easy to cause various diseases. Therefore, developing drugs with anti-aging effects is of great significance for improving the quality of life of the elderly population.

[0004] Existing drugs for treating Alzheimer's disease mainly include acetylcholinesterase inhibitors and NMDA receptor antagonists, but these drugs can only temporarily relieve symptoms, cannot prevent the progression of the disease, and may produce obvious side effects after long-term use. Therefore, there is an urgent need to develop new therapeutic drugs with better efficacy and fewer side effects.

[0005] Traditional Chinese medicine has unique advantages in preventing and treating neurodegenerative diseases. Through compound compatibility, it can achieve multi-target and multi-pathway synergistic effects and improve the symptoms and quality of life of patients. Chinese medicinal materials such as ginger, cistanche, and ganoderma lucidum have significant antioxidant, anti-inflammatory, neuroprotective, and immunomodulatory effects and play an important role in the prevention and treatment of anti-aging and neurodegenerative diseases.

[0006] Therefore, those skilled in the art have provided a compound component for treating Alzheimer's disease and anti-aging and a preparation method thereof to solve the problems raised in the above background art. Summary of the Invention

[0007] (I) Technical Problems to be Solved

[0008] In view of the deficiencies of the prior art, the present invention provides a compound component for treating Alzheimer's disease and anti-aging, which can effectively treat Alzheimer's disease and has an anti-aging effect. Through scientific proportioning and preparation methods, the synergistic effects of each component are fully exerted, providing a safe and effective treatment plan, and solving the problem that the existing drugs for treating Alzheimer's disease mainly include acetylcholinesterase inhibitors and NMDA receptor antagonists, but these drugs can only relieve symptoms temporarily, cannot prevent the progression of the disease, and may produce obvious side effects after long-term use.

[0009] (II) Technical Solution

[0010] To achieve the above objectives, the present invention is realized through the following technical solutions:

[0011] A compound component for treating Alzheimer's disease and anti-aging is mainly composed of six raw materials: ginger extract, cistanche extract, salvia extract, ganoderma extract, polygonatum extract, and licorice extract. The weight parts of each component are as follows: ginger extract 10-20 parts, cistanche extract 20-40 parts, salvia extract 10-15 parts, ganoderma extract 15-30 parts, polygonatum extract 5-10 parts, licorice extract 3-5 parts, and surfactant 5-10 parts.

[0012] Further, the weight parts of each component are as follows: ginger extract 15 parts, cistanche extract 25 parts, salvia extract 12 parts, ganoderma extract 22 parts, polygonatum extract 8 parts, licorice extract 4 parts, and surfactant 7 parts.

[0013] Further, the weight parts of each component are as follows: ginger extract 20 parts, cistanche extract 40 parts, salvia extract 15 parts, ganoderma extract 30 parts, polygonatum extract 10 parts, licorice extract 5 parts, and surfactant 10 parts.

[0014] Further, the weight parts of each component are as follows: ginger extract 10 parts, cistanche extract 20 parts, salvia extract 10 parts, ganoderma extract 15 parts, polygonatum extract 5 parts, licorice extract 3 parts, and surfactant 5 parts.

[0015] Further, the surfactant is selected from one or a combination of more of polyoxyethylene ether-40 hydrogenated castor oil, poloxamer 188, and lecithin E-80.

[0016] Further, the preparation dosage forms of the compound component include tablets, capsules, and granules.

[0017] Further, a preparation method of a compound component for treating Alzheimer's disease and anti-aging includes the following steps:

[0018] Step 1. Extraction

[0019] Crush ginger, cistanche, ganoderma lucidum, salvia miltiorrhiza, polygonatum sibiricum and liquorice respectively, then reflux extract with 70% ethanol, combine the extracts, and then concentrate under reduced pressure;

[0020] Step 2. Purification

[0021] Purify through HPD100 macroporous resin, collect the 70% ethanol eluate, concentrate and dry to obtain their respective extracts;

[0022] Step 3. Mixing

[0023] Mix the ginger extract, cistanche extract, ganoderma lucidum extract, salvia miltiorrhiza extract, polygonatum sibiricum extract and liquorice extract evenly according to the weight ratio, and add a surfactant to the mixture, and stir well to obtain a mixed paste;

[0024] Step 4. Preparation

[0025] Prepare the above-mentioned mixed paste into tablets, capsules or granules as needed.

[0026] Furthermore, the preparation process of the capsule finished product of the compound component is as follows:

[0027] 1) Stir and mix the ginger extract, cistanche extract, salvia miltiorrhiza extract, ganoderma lucidum extract, polygonatum sibiricum extract and liquorice extract, and then stir and mix the mixed powder, surfactant and appropriate excipients such as microcrystalline cellulose and silicon dioxide;

[0028] 2) Then dry the mixture, controlling the moisture content to be below 5%;

[0029] 3) Use a capsule filling machine to fill the mixture into empty capsules with accurate filling amount to obtain the finished product;

[0030] The preparation process of the granule finished product of the compound component is as follows:

[0031] 1) Stir and mix the ginger extract, cistanche extract, salvia miltiorrhiza extract, ganoderma lucidum extract, polygonatum sibiricum extract and liquorice extract at a high speed, the stirring speed is 2900 revolutions per minute, and add a surfactant during the stirring and mixing process, and homogenize again;

[0032] 2) Place the mixture in an ultrasonic instrument for ultrasonic treatment for 20 - 30 min, and the frequency is 50 - 60 Hz;

[0033] 3) Then send it to a granulator for granulation to obtain a semi-finished product of traditional Chinese medicine granules;

[0034] 4) The semi-finished product is further dried to obtain the granule finished product.

[0035] Furthermore, the application of the compound component in the preparation of drugs for treating Alzheimer's disease and anti-aging.

[0036] (III) Beneficial effects

[0037] The present invention provides a compound component for treating Alzheimer's disease and anti-aging and its preparation method, which has the following beneficial effects:

[0038] The present invention provides a compound component for treating Alzheimer's disease and anti-aging and its preparation method. The compound component can play a therapeutic role through multiple mechanisms, including antioxidant, anti-inflammatory, neuroprotective, immunomodulatory, etc. The compound can significantly improve cognitive function, enhance memory, and has a good therapeutic effect on Alzheimer's disease. At the same time, the compound component has an anti-aging effect and can delay the aging process of the body.

[0039] The present invention provides a compound component for treating Alzheimer's disease and anti-aging and its preparation method. It uses natural drug ingredients, has high safety, low side effects, and improves the therapeutic effect through the synergistic effect of multiple targets and multiple pathways.

[0040] The present invention provides a compound component for treating Alzheimer's disease and anti-aging and its preparation method. Its preparation method is simple, can be industrially produced, can be used to prepare drugs for treating Alzheimer's disease and anti-aging, and has broad application prospects. Brief description of the drawings

[0041] Figure 1 It is a schematic diagram of the inhibitory activity of the compound extract of the present invention against AChE. Detailed implementation manners

[0042] In order to further understand the present invention, the technical solutions in the specific implementation manners of the present invention will be clearly and completely described below in conjunction with the drawings in the specific implementation manners of the present invention. Obviously, the described specific implementation manners are only a part of the specific implementation manners of the present invention, rather than all of the specific implementation manners. Based on the specific implementation manners of the present invention, all other specific implementation manners obtained by those of ordinary skill in the art without creative efforts belong to the scope of protection of the present invention.

[0043] Unless otherwise specified, the reagents involved in the specific implementation manners of the present invention are all commercially available products and can be obtained through commercial channels.

[0044] Selection of raw materials

[0045] 1. Ginger: Rich in gingerol, zingerone, etc., and has antioxidant, anti-inflammatory and anti-aging effects.

[0046] 2. Cistanche deserticola: It contains phenyl ethanol glycosides, lignans, etc., and has the effects of improving memory, anti-fatigue, antioxidant, etc.

[0047] 3. Ganoderma lucidum: It is rich in triterpenoids, polysaccharides, etc., and has immunomodulatory, antioxidant and neuroprotective effects.

[0048] 4. Salvia miltiorrhiza: It contains tanshinone, salvianolic acid and flavonoid compounds, and has the effects of antioxidant, anti-inflammatory, anticoagulant, and protecting the cardiovascular and nervous systems.

[0049] 5. Polygonatum sibiricum: It contains saponins, amino acids, betaine and trace elements such as zinc, and has the effects of enhancing and modulating immunity. It can dilate blood vessels, inhibit platelet aggregation, reduce blood viscosity, improve blood circulation and cerebral perfusion.

[0050] 6. Glycyrrhiza uralensis: It contains a variety of chemical components, and the main components are glycyrrhizic acid and liquiritin. It has the effects of regulating body immunity, anti-aging, anti-inflammatory, anti-pathogenic microorganisms, sedation, anti-tumor, improving cardiovascular function, invigorating the spleen and replenishing qi, moistening the lungs and relieving cough, clearing heat and detoxifying, relieving pain, moderating the properties of drugs, and expelling phlegm. Specific Embodiment 1:

[0052] The specific embodiment of the present invention provides a compound component for treating Alzheimer's disease and anti-aging, which is mainly composed of six raw materials: ginger extract, Cistanche deserticola extract, Salvia miltiorrhiza extract, Ganoderma lucidum extract, Polygonatum sibiricum extract, and Glycyrrhiza uralensis extract. The weight parts of each component are as follows: ginger extract 15 parts, Cistanche deserticola extract 25 parts, Salvia miltiorrhiza extract 12 parts, Ganoderma lucidum extract 22 parts, Polygonatum sibiricum extract 8 parts, Glycyrrhiza uralensis extract 4 parts, and surfactant 7 parts.

[0053] By adopting the methods of reflux extraction with 70% ethanol and purification by macroporous resin, extracts rich in active ingredients are obtained. After mixing, oral preparations such as tablets, capsules, and granules can be prepared.

[0054] The surfactant is selected from polyoxyethylene ether-40 hydrogenated castor oil.

[0055] The preparation method of the compound component for treating Alzheimer's disease and anti-aging includes the following steps:

[0056] Step 1. Extraction

[0057] Ginger, Cistanche deserticola, Ganoderma lucidum, Salvia miltiorrhiza, Polygonatum sibiricum and Glycyrrhiza uralensis are respectively crushed, then reflux extracted with 70% ethanol, the extraction solutions are combined, and then concentrated under reduced pressure;

[0058] Step 2. Purification

[0059] Purify through HPD100 macroporous resin, collect the 70% ethanol eluate, concentrate and dry to obtain respective extracts;

[0060] Step 3. Mix

[0061] The ginger extract, the Cistanche deserticola extract, the Ganoderma lucidum extract, the Salvia miltiorrhiza extract, the Polygonatum sibiricum extract, and the Licorice extract are uniformly mixed according to the weight ratio, and a surfactant is added to the mixture, and the mixture is fully stirred and mixed to obtain a mixed paste;

[0062] Step 4. Preparation

[0063] The mixed paste is prepared into tablets, capsules or granules as required.

[0064] The preparation process of the compound component as a finished capsule is as follows:

[0065] 1) Stir and mix ginger extract, Cistanche deserticola extract, Salvia miltiorrhiza extract, Ganoderma lucidum extract, Polygonatum sibiricum extract, and Licorice extract, and then stir and mix the mixed powder, surfactant, and appropriate amounts of auxiliary materials, such as microcrystalline cellulose and silicon dioxide;

[0066] 2) Dry the mixture to control the moisture content below 5%;

[0067] 3) Use a capsule filling machine to fill the mixture into hollow capsules with accurate filling amount to obtain the finished product;

[0068] The preparation process of the compound component as a granule finished product is as follows:

[0069] 1) Ginger extract, Cistanche deserticola extract, Salvia miltiorrhiza extract, Ganoderma lucidum extract, Polygonatum sibiricum extract, and Licorice extract are mixed by high-speed stirring at a stirring speed of 2900 rpm, and a surfactant is added during the stirring and mixing process, and the mixture is homogenized again;

[0070] 2) The mixture was ultrasonicated in an ultrasonicator for 25 min at a frequency of 55 Hz;

[0071] 3) Then send it to the granulator for granulation to obtain the semi-finished Chinese medicine granules;

[0072] 4) The semi-finished product is then dried to obtain the finished granule product.

[0073] The preparation method of the compound component as a finished tablet is the same as that of the capsule, except that a tablet machine is used for the final tableting process. Specific implementation 2:

[0075] A specific embodiment of the present invention provides a compound component for treating Alzheimer's disease and anti-aging, which is mainly composed of six raw materials: ginger extract, Cistanche extract, Salvia miltiorrhiza extract, Ganoderma lucidum extract, Polygonatum sibiricum extract, and Licorice extract. The weight parts of each component are respectively: 20 parts of ginger extract, 40 parts of Cistanche extract, 15 parts of Salvia miltiorrhiza extract, 30 parts of Ganoderma lucidum extract, 10 parts of Polygonatum sibiricum extract, 5 parts of Licorice extract, and 10 parts of surfactant.

[0076] By adopting the method of 70% ethanol reflux extraction and macroporous resin purification, an extract rich in active ingredients is obtained, which can be prepared into oral preparations such as tablets, capsules, granules, etc. after mixing.

[0077] The surfactant is selected from Poloxamer 188.

[0078] The preparation method of the compound component for treating Alzheimer's disease and resisting aging comprises the following steps:

[0079] Step 1. Extraction

[0080] Ginger, Cistanche deserticola, Ganoderma lucidum, Salvia miltiorrhiza, Polygonatum sibiricum and Licorice were crushed separately, then extracted with 70% ethanol by reflux, the extracts were combined, and then concentrated under reduced pressure;

[0081] Step 2. Purification

[0082] Purification was performed by HPD100 macroporous resin, and the 70% ethanol eluate was collected, concentrated and dried to obtain the respective extracts;

[0083] Step 3. Mix

[0084] The ginger extract, the Cistanche deserticola extract, the Ganoderma lucidum extract, the Salvia miltiorrhiza extract, the Polygonatum sibiricum extract, and the Licorice extract are uniformly mixed according to the weight ratio, and a surfactant is added to the mixture, and the mixture is fully stirred and mixed to obtain a mixed paste;

[0085] Step 4. Preparation

[0086] The mixed paste is prepared into tablets, capsules or granules as required.

[0087] The preparation process of the compound component as a finished capsule is as follows:

[0088] 1) Stir and mix ginger extract, Cistanche deserticola extract, Salvia miltiorrhiza extract, Ganoderma lucidum extract, Polygonatum sibiricum extract, and Licorice extract, and then stir and mix the mixed powder, surfactant, and appropriate amounts of auxiliary materials, such as microcrystalline cellulose and silicon dioxide;

[0089] 2) Dry the mixture to control the moisture content below 5%;

[0090] 3) Use a capsule filling machine to fill the mixture into empty capsules with accurate filling amounts to obtain the finished product;

[0091] The preparation process of the finished product of the compound component in the form of granules is as follows:

[0092] 1) Mix the ginger extract, cistanche extract, salvia miltiorrhiza extract, ganoderma lucidum extract, polygonatum sibiricum extract, and licorice extract by high-speed stirring at a stirring speed of 2900 revolutions per minute. Add a surfactant during the stirring and mixing process and homogenize again;

[0093] 2) Place the mixture in an ultrasonic instrument for ultrasonic treatment for 30 minutes at a frequency of 60 Hz;

[0094] 3) Then send it to a granulator for granulation to obtain the semi-finished product of traditional Chinese medicine granules;

[0095] 4) The semi-finished product is further dried to obtain the finished product of granules.

[0096] The preparation method of the finished product of the compound component in the form of tablets is the same as that of the capsules, and the difference lies in that a tablet making machine is finally used for tablet making treatment. Specific Embodiment 3:

[0098] The specific embodiment of the present invention provides a compound component for treating Alzheimer's disease and anti-aging, mainly composed of six raw medicinal materials: ginger extract, cistanche extract, salvia miltiorrhiza extract, ganoderma lucidum extract, polygonatum sibiricum extract, and licorice extract. The weight parts of each component are as follows: The weight parts of each component are: 10 parts of ginger extract, 20 parts of cistanche extract, 10 parts of salvia miltiorrhiza extract, 15 parts of ganoderma lucidum extract, 5 parts of polygonatum sibiricum extract, 3 parts of licorice extract, and 5 parts of surfactant.

[0099] By adopting the methods of reflux extraction with 70% ethanol and purification with macroporous resin, extracts rich in active ingredients are obtained. After mixing, oral preparations such as tablets, capsules, and granules can be prepared.

[0100] The surfactant is selected from lecithin E-80.

[0101] The preparation method of the compound component for treating Alzheimer's disease and anti-aging includes the following steps:

[0102] Step 1. Extraction

[0103] Crush ginger, cistanche, ganoderma lucidum, salvia miltiorrhiza, polygonatum sibiricum, and licorice respectively, then reflux extract with 70% ethanol, combine the extract solutions, and then concentrate under reduced pressure;

[0104] Step 2. Purification

[0105] Purification was performed by HPD100 macroporous resin, and the 70% ethanol eluate was collected, concentrated and dried to obtain the respective extracts;

[0106] Step 3. Mix

[0107] The ginger extract, the Cistanche deserticola extract, the Ganoderma lucidum extract, the Salvia miltiorrhiza extract, the Polygonatum sibiricum extract, and the Licorice extract are uniformly mixed according to the weight ratio, and a surfactant is added to the mixture, and the mixture is fully stirred and mixed to obtain a mixed paste;

[0108] Step 4. Preparation

[0109] The mixed paste is prepared into tablets, capsules or granules as required.

[0110] The preparation process of the compound component as a finished capsule is as follows:

[0111] 1) Stir and mix ginger extract, Cistanche deserticola extract, Salvia miltiorrhiza extract, Ganoderma lucidum extract, Polygonatum sibiricum extract, and Licorice extract, and then stir and mix the mixed powder, surfactant, and appropriate amounts of auxiliary materials, such as microcrystalline cellulose and silicon dioxide;

[0112] 2) Dry the mixture to control the moisture content below 5%;

[0113] 3) Use a capsule filling machine to fill the mixture into hollow capsules with accurate filling amount to obtain the finished product;

[0114] The preparation process of the compound component as a granule finished product is as follows:

[0115] 1) Ginger extract, Cistanche deserticola extract, Salvia miltiorrhiza extract, Ganoderma lucidum extract, Polygonatum sibiricum extract, and Licorice extract are mixed by high-speed stirring at a stirring speed of 2900 rpm, and a surfactant is added during the stirring and mixing process, and the mixture is homogenized again;

[0116] 2) The mixture was placed in an ultrasonicator and sonicated for 20 min at a frequency of 50 Hz;

[0117] 3) Then send it to the granulator for granulation to obtain the semi-finished Chinese medicine granules;

[0118] 4) The semi-finished product is then dried to obtain the finished granule product.

[0119] The preparation method of the compound component as a finished tablet is the same as that of the capsule, except that a tablet machine is used for the final tableting process.

[0120] Pharmacological experiments:

[0121] This invention uses in vitro bioactivity assays to evaluate the inhibitory effects of the compound components on Alzheimer's disease-related targets, mainly by measuring the half inhibitory concentration (IC 50 ) for evaluation.

[0122] Determination of acetylcholinesterase (AChE) inhibitory activity

[0123] Reagent preparation: Prepare compound extract solutions with different concentrations (concentration range: 0.01 mg / mL - 1 mg / mL);

[0124] Enzyme reaction: At 37 °C, mix the compound solution with AChE enzyme and the substrate acetylthiocholine (ATCI), and react for 15 minutes;

[0125] Detection: Add 5,5'-dithiobis(2-nitrobenzoic acid) (DTNB), and measure the absorbance at a wavelength of 412 nm.

[0126] Result analysis:

[0127] Calculate the AChE inhibition rate at each concentration, plot the logarithm of the inhibition rate against the concentration, as Figure 1 shown, and calculate the IC 50 value.

[0128] Experimental results:

[0129] The IC 50 value of this compound component for AChE is 20.32 mM, showing strong inhibitory activity.

[0130] Application prospects:

[0131] The compound component of this invention has verified its significant inhibitory effects on Alzheimer's disease-related targets through in vitro experiments, and may have multiple effects such as antioxidant, neuroprotective, and inhibition of Aβ aggregation.

[0132] Due to its use of natural drug ingredients, it has high safety and can be used to prepare drugs for the treatment of Alzheimer's disease and anti-aging, with broad market prospects.

[0133] Although the specific embodiments of the present invention have been shown and described, it will be understood by those of ordinary skill in the art that various changes, modifications, substitutions, and variations can be made to these specific embodiments without departing from the principles and spirit of the present invention, and the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A compound component for treating Alzheimer's disease, comprising six raw materials: ginger extract, Cistanche deserticola extract, Salvia miltiorrhiza extract, Ganoderma lucidum extract, Polygonatum sibiricum extract, and Licorice extract, characterized in that: The weight proportions of the components are as follows: 10-20 parts of ginger extract, 20-40 parts of Cistanche deserticola extract, 10-15 parts of Salvia miltiorrhiza extract, 15-30 parts of Ganoderma lucidum extract, 5-10 parts of Polygonatum sibiricum extract, 3-5 parts of Licorice extract, and 5-10 parts of surfactant; The ginger extract, Cistanche deserticola extract, Salvia miltiorrhiza extract, Ganoderma lucidum extract, Polygonatum sibiricum extract and Licorice extract are extracted by the following method: Step 1. Extraction Ginger, Cistanche deserticola, Ganoderma lucidum, Salvia miltiorrhiza, Polygonatum sibiricum and Licorice were crushed separately, then extracted with 70% ethanol by reflux, the extracts were combined, and then concentrated under reduced pressure; Step 2. Purification The extracts were purified by HPD100 macroporous resin, and the 70% ethanol eluate was collected, concentrated and dried to obtain the respective extracts.

2. The compound composition for treating Alzheimer's disease according to claim 1, characterized in that: The weight proportions of the components are as follows: 15 parts of ginger extract, 25 parts of Cistanche deserticola extract, 12 parts of Salvia miltiorrhiza extract, 22 parts of Ganoderma lucidum extract, 8 parts of Polygonatum sibiricum extract, 4 parts of Licorice extract and 7 parts of surfactant.

3. The compound composition for treating Alzheimer's disease according to claim 1, characterized in that: The weight proportions of the components are as follows: 20 parts of ginger extract, 40 parts of Cistanche deserticola extract, 15 parts of Salvia miltiorrhiza extract, 30 parts of Ganoderma lucidum extract, 10 parts of Polygonatum sibiricum extract, 5 parts of Licorice extract and 10 parts of surfactant.

4. The compound composition for treating Alzheimer's disease according to claim 1, characterized in that: The weight proportions of the components are as follows: 10 parts of ginger extract, 20 parts of Cistanche deserticola extract, 10 parts of Salvia miltiorrhiza extract, 15 parts of Ganoderma lucidum extract, 5 parts of Polygonatum sibiricum extract, 3 parts of Licorice extract and 5 parts of surfactant.

5. The compound composition for treating Alzheimer's disease according to claim 1, characterized in that: The surfactant is selected from one or more combinations of polyoxyethylene ether-40 hydrogenated castor oil, poloxamer 188, and lecithin E-80.

6. The compound composition for treating Alzheimer's disease according to claim 1, characterized in that: The dosage forms of the compound components include tablets, capsules and granules.

7. A method for preparing the compound component for treating Alzheimer's disease as claimed in claim 1, characterized in that: The following steps are involved: Step 1. Extraction Ginger, Cistanche deserticola, Ganoderma lucidum, Salvia miltiorrhiza, Polygonatum sibiricum and Licorice were crushed separately, then extracted with 70% ethanol by reflux, the extracts were combined, and then concentrated under reduced pressure; Step 2. Purification Purification was performed by HPD100 macroporous resin, and the 70% ethanol eluate was collected, concentrated and dried to obtain the respective extracts; Step 3. Mix The ginger extract, the Cistanche deserticola extract, the Ganoderma lucidum extract, the Salvia miltiorrhiza extract, the Polygonatum sibiricum extract, and the Licorice extract are uniformly mixed according to the weight ratio, and a surfactant is added to the mixture, and the mixture is fully stirred and mixed to obtain a mixed paste; Step 4. Preparation The mixed paste is prepared into tablets, capsules or granules as required.

8. The method for preparing the compound component for treating Alzheimer's disease according to claim 7, characterized in that: The preparation process of the compound component as a finished capsule is as follows: 1) stirring and mixing ginger extract, Cistanche deserticola extract, Salvia miltiorrhiza extract, Ganoderma lucidum extract, Polygonatum sibiricum extract, and Licorice extract, and then stirring and mixing the mixed powder, surfactant, and appropriate amount of auxiliary materials, wherein the auxiliary materials are microcrystalline cellulose and silicon dioxide; 2) Dry the mixture to control the moisture content below 5%; 3) Use a capsule filling machine to fill the mixture into hollow capsules with accurate filling amount to obtain the finished product; The preparation process of the compound component as a granule finished product is as follows: 1) Ginger extract, Cistanche deserticola extract, Salvia miltiorrhiza extract, Ganoderma lucidum extract, Polygonatum sibiricum extract, and Licorice extract are mixed by high-speed stirring at a stirring speed of 2900 rpm, and a surfactant is added during the stirring and mixing process, and the mixture is homogenized again; 2) Place the mixture in an ultrasonic device and perform ultrasonic treatment for 20 to 30 minutes at a frequency of 50 to 60 Hz; 3) Then send it to the granulator for granulation to obtain the semi-finished Chinese medicine granules; 4) The semi-finished product is then dried to obtain the finished granule product.

9. Use of the compound component according to claim 1 in preparing a drug for treating Alzheimer's disease.

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