Freeze-dried material transfer mechanism, double-chamber pre-filled syringe production line, production method, control device and storage medium

Abstract

The application provides a freeze-dried material transfer mechanism, a double-cavity pre-filled syringe production line, a production method, a control device and a storage medium. The freeze-dried material transfer mechanism is provided with a first feeding conveying assembly for feeding medicinal containers, a second feeding conveying assembly for feeding freeze-dried materials, and a taking and placing assembly for transferring the freeze-dried materials supplied by the second feeding conveying assembly into the medicinal containers supplied by the first feeding conveying assembly. The second feeding conveying assembly comprises coaxially arranged first and second screws. The feeding state of the freeze-dried materials can be adjusted by different rotation frequencies of the first and second screws. Thus, the feeding of the freeze-dried materials can be matched with the feeding of the medicinal containers, thereby improving the pre-filling and production effect of the double-cavity pre-filled syringe.

Description

Technical Field

[0001] This application relates to the field of medical equipment technology, specifically to a freeze-dried material transfer mechanism, a dual-chamber pre-filled syringe production line, a production method, a control device, and a storage medium. Background Technology

[0002] A syringe is a common medical device, primarily used to draw or inject liquids through a needle.

[0003] A special type of syringe is the dual-chamber pre-filled syringe, which is widely used in situations requiring the mixing of multiple drugs or liquids. This type of syringe has two independent chambers, each storing a different liquid or drug, and a connecting channel on the syringe barrel to link the two chambers. In use, the user presses the syringe plunger to change the position of the rubber stopper inside the syringe. When the stopper moves to the connecting channel, the two chambers are connected, allowing the components in both chambers to mix.

[0004] However, current production equipment is not well capable of pre-filling and producing dual-chamber pre-filled syringes. Summary of the Invention

[0005] This application provides a freeze-dried material transfer mechanism, a dual-chamber pre-filled syringe production line, a production method, a control device, and a storage medium to improve the pre-filling and production of dual-chamber pre-filled syringes.

[0006] A first aspect of this application provides a freeze-dried material transfer mechanism, comprising,

[0007] The first feeding and conveying assembly is used to feed pharmaceutical containers;

[0008] The second feeding and conveying assembly is used to feed freeze-dried materials. The second feeding and conveying assembly includes a first driving mechanism, a second driving mechanism, and a first screw and a second screw arranged coaxially. The first driving mechanism is driven to the first screw, and the second driving mechanism is driven to the second screw. The first screw and the second screw are arranged adjacent to each other along the conveying direction of the second feeding and conveying assembly. The assembly also includes a pick-and-place assembly for transferring the freeze-dried materials supplied by the second feeding and conveying assembly into a pharmaceutical container supplied by the first feeding and conveying assembly.

[0009] In some embodiments, the second screw is provided with a first feeding position and a second feeding position, the first feeding position is located downstream of the second feeding position, and the feeding state of the second screw can be adjusted by switching the rotation frequency.

[0010] In some embodiments, the second screw can switch between four feeding states, wherein in the first feeding state, both the first feeding position and the second feeding position have freeze-dried material; in the second feeding state, the first feeding position does not have freeze-dried material, but the second feeding position does; in the third feeding state, the first feeding position has freeze-dried material, but the second feeding position does not; and in the fourth feeding state, neither the first feeding position nor the second feeding position has freeze-dried material.

[0011] In some embodiments, the freeze-dried material transfer mechanism further includes a detection mechanism for detecting the pharmaceutical container being fed and obtaining a detection result; the second feeding and conveying assembly adjusts the feeding state of the second screw according to the detection result.

[0012] In some embodiments, the pick-and-place assembly includes a drive mechanism and at least one set of pick-and-place units. The drive mechanism is used to drive the pick-and-place units to move between the first feeding conveying assembly and the second feeding conveying assembly to feed the freeze-dried material into a pharmaceutical container.

[0013] In some embodiments, the drive unit can drive the pick-and-place unit to switch between a first station and a third station; at the first station, at least one set of the pick-and-place units corresponds to a first feeding position and a second feeding position of the second screw to obtain freeze-dried material; at the third station, at least one set of the pick-and-place units corresponds to a position of the first feeding and conveying assembly to place the freeze-dried material into a pharmaceutical container.

[0014] In some embodiments, the driving member can also drive the pick-and-place unit to a second station, where a second detection mechanism is provided for detecting the freeze-dried material.

[0015] In some embodiments, the driving element may also drive the pick-and-place unit to a fourth station, which is a cleaning station.

[0016] In some embodiments, each set of pick-and-place units includes two pick-and-place components, and the arrangement of the two pick-and-place components corresponds to the arrangement of the first feeding position and the second feeding position.

[0017] In some embodiments, the driving member includes a rotary driving member, which is tractively connected to the pick-and-place unit to drive the pick-and-place unit to rotate and switch between a first station, a second station, a third station, and a fourth station; the first station, the second station, the third station, and the fourth station are arranged evenly in sequence along the circumference.

[0018] In some embodiments, the pick-and-place unit includes at least one pick-and-place component, which is a vacuum adsorption component, and a collection container is provided at the fourth station for collecting the ejected material when the pick-and-place component sprays air outward.

[0019] In some embodiments, the pick-and-place assembly is further provided with a central shaft, a vacuum source, and a support. The central shaft is connected to the support via the air slip ring. The vacuum source gas is connected to the air slip ring, and the air slip ring gas is connected to each of the vacuum adsorption elements to provide positive or negative pressure to each of the vacuum adsorption elements.

[0020] In some embodiments, the pick-and-place assembly includes four sets of pick-and-place units, which are evenly arranged circumferentially.

[0021] In some embodiments, the driving component further includes a lifting driving component connected to the pick-and-place unit for driving the pick-and-place unit to move up and down.

[0022] In some embodiments, the freeze-dried material transfer mechanism further includes a connector, the rotary drive is disposed on the connector, the pick-and-place assembly has a central shaft, the pick-and-place unit is connected to the central shaft, the central shaft is rotatably connected to the connector and is drivenly connected to the rotary drive, and the lifting drive is connected to the connector to drive the connector, the rotary drive, and the pick-and-place unit to lift.

[0023] In some embodiments, the freeze-dried material transfer mechanism further includes a guide post, a guide sleeve, and a fixing frame. One of the guide post and the guide sleeve is connected to the fixing frame, and the other is connected to the connector. The guide post is fitted inside the guide sleeve and extends along the direction of lifting and lowering of the connector.

[0024] A second aspect of this application provides a dual-chamber pre-filled syringe production line, comprising a filling unit, the filling unit including:

[0025] A first sealing mechanism is used to provide a first sealing body in a pharmaceutical container;

[0026] A filling mechanism is located downstream of the first sealing mechanism, and the filling mechanism is used to fill liquid into a pharmaceutical container;

[0027] A second sealing mechanism is disposed downstream of the filling mechanism. The second sealing mechanism is used to provide a second sealing body in the pharmaceutical container, and a liquid chamber for containing the liquid is formed between the first sealing body and the second sealing body.

[0028] The freeze-dried material transfer mechanism provided in any of the foregoing embodiments is disposed downstream of the second sealing mechanism for adding freeze-dried material into the pharmaceutical container;

[0029] A third sealing mechanism is disposed downstream of the freeze-dried material transfer mechanism for providing a third sealing body in the pharmaceutical container for sealing the freeze-dried material.

[0030] In some embodiments, a first flipping mechanism is provided downstream of the second sealing mechanism and upstream of the freeze-dried material removal mechanism. The first flipping mechanism is used to flip the pharmaceutical container. A chamber for accommodating the freeze-dried material is formed between the first sealing body and the third sealing body.

[0031] In some embodiments, the dual-chamber pre-filled syringe production line further includes a third detection mechanism located downstream of the freeze-dried material transfer mechanism and upstream of the third sealing mechanism, for detecting the communication status between the liquid chamber for containing liquid and the chamber for containing freeze-dried material within the pharmaceutical container.

[0032] In some embodiments, the dual-chamber pre-filled syringe production line further includes a laminar flow hood, in which the first sealing mechanism, the filling mechanism, the second sealing mechanism, and the freeze-dried material removal mechanism are disposed and are in a Class A laminar flow environment.

[0033] In some embodiments, the dual-chamber pre-filled syringe production line further includes:

[0034] A pharmaceutical container supply unit is disposed upstream of the filling unit for supplying pharmaceutical containers to the filling unit;

[0035] A freeze-dried material supply unit is located upstream of the filling unit for supplying freeze-dried material to the filling unit; and a discharge unit is located downstream of the filling unit for discharging material from a pharmaceutical container pre-filled with liquid components and freeze-dried material after assembling it into a syringe.

[0036] A third aspect of this application provides a method for manufacturing a dual-chamber pre-filled syringe, comprising the following steps:

[0037] The pharmaceutical containers are fed through the first feeding and conveying assembly;

[0038] The freeze-dried material is fed through the second feeding and conveying assembly;

[0039] The freeze-dried material supplied by the second feeding and conveying component is transferred to the pharmaceutical container supplied by the first feeding and conveying component by the pick-and-place component;

[0040] The second feeding and conveying assembly has four feeding states. In the first feeding state, both the first and second feeding positions of the second feeding and conveying assembly have freeze-dried material. In the second feeding state, the first feeding position does not have freeze-dried material, but the second feeding position does. In the third feeding state, the first feeding position has freeze-dried material, but the second feeding position does not. In the fourth feeding state, neither the first nor the second feeding position has freeze-dried material.

[0041] In some embodiments, the method further includes the following steps: testing the pharmaceutical container being fed by a testing agency and obtaining the testing results; and switching the feeding state of the second feeding conveying component according to the testing results.

[0042] In some embodiments, the step of transferring the freeze-dried material supplied by the second feeding conveyor assembly to the pharmaceutical container supplied by the first feeding conveyor assembly via the pick-and-place assembly specifically includes:

[0043] At the first station, the freeze-dried material supplied by the second feeding and conveying component is obtained through the pick-and-place component;

[0044] Rotate the pick-and-place assembly to the third station and place the freeze-dried material into a pharmaceutical container.

[0045] In some embodiments, before the step of rotating the pick-and-place assembly to the third station and placing the freeze-dried material into the pharmaceutical container, the pick-and-place assembly is rotated to the second station, and the freeze-dried material is tested by a second testing mechanism.

[0046] In some embodiments, the pick-and-place assembly removes the lyophilized material by vacuum adsorption. After the step of rotating the pick-and-place assembly to the third station and placing the lyophilized material in the pharmaceutical container, the pick-and-place assembly is rotated to the fourth station, and air is sprayed outward at the fourth station to clean the air passage of the pick-and-place assembly.

[0047] In some embodiments, prior to the step of feeding the pharmaceutical container via the first feeding conveyor assembly, the pharmaceutical container is filled with liquid to form a liquid chamber for containing the liquid.

[0048] In some embodiments, before the step of feeding the pharmaceutical container through the first feeding conveyor assembly, the pharmaceutical container is supplied by the pharmaceutical container supply unit; before the step of feeding the lyophilized material through the second feeding conveyor assembly, the lyophilized material is supplied by the lyophilized material supply unit; after the step of transferring the lyophilized material supplied by the second feeding conveyor assembly to the pharmaceutical container supplied by the first feeding conveyor assembly through the pick-and-place assembly, the pharmaceutical container pre-filled with liquid components and lyophilized material is assembled into a syringe by the discharge unit and then discharged.

[0049] A fourth aspect of this application provides a control device for a dual-chamber pre-filled syringe production line, comprising,

[0050] The freeze-dried material transfer mechanism provided in any of the foregoing embodiments;

[0051] Testing agencies are used to test pharmaceutical containers used for feeding materials and obtain test results;

[0052] The controller is signal-connected to the freeze-dried material transfer mechanism and the detection mechanism, and adjusts the feeding state of the second screw of the freeze-dried material transfer mechanism according to the detection results.

[0053] A fifth aspect of this application provides a non-volatile computer-readable storage medium storing a computer program that is executed by a processor to implement the steps in the method for producing a dual-chamber pre-filled syringe provided in any of the foregoing embodiments.

[0054] This application provides the following beneficial effects: A freeze-dried material transfer mechanism, a dual-chamber pre-filled syringe production line, a production method, a control device, and a storage medium. The freeze-dried material transfer mechanism includes a first feeding conveyor assembly for feeding pharmaceutical containers, a second feeding conveyor assembly for feeding freeze-dried materials, and a pick-and-place assembly for transferring the freeze-dried materials supplied by the second feeding conveyor assembly into the pharmaceutical containers supplied by the first feeding conveyor assembly. The second feeding conveyor assembly includes a first screw and a second screw coaxially arranged. The feeding state of the freeze-dried material can be adjusted by using different rotation frequencies of the first and second screws. Therefore, the feeding of the freeze-dried material can be matched with the feeding of the pharmaceutical containers, thereby improving the pre-filling and production effect of the dual-chamber pre-filled syringes. Attached Figure Description

[0055] To more clearly illustrate the technical solutions in the embodiments of this application, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the accompanying drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0056] Figure 1 An exemplary top view of a freeze-dried material transfer mechanism is shown.

[0057] Figure 2 An exemplary schematic diagram of a freeze-dried material transfer mechanism is shown.

[0058] Figure 3 An exemplary front view of a freeze-dried material transfer mechanism is shown.

[0059] Figure 4 An exemplary schematic diagram shows the second feeding and conveying assembly in the first feeding state.

[0060] Figure 5 An exemplary schematic diagram shows the second feeding and conveying assembly in the second feeding state.

[0061] Figure 6 An exemplary schematic diagram shows the second feeding and conveying assembly in the third feeding state.

[0062] Figure 7 An exemplary schematic diagram shows the second feeding and conveying assembly in the fourth feeding state.

[0063] Figure 8 An exemplary schematic diagram of the other side of a freeze-dried material transfer mechanism is shown.

[0064] Figure 9 An exemplary side view of a freeze-dried material transfer mechanism is shown.

[0065] Figure 10 An exemplary schematic diagram of a dual-chamber pre-filled syringe production line is shown.

[0066] Figure 11 An exemplary flowchart illustrates a method for manufacturing a dual-chamber pre-filled syringe.

[0067] Figure 12 A schematic diagram of a control device for a dual-chamber pre-filled syringe production line is shown as an example.

[0068] The components in the attached diagram are described as follows: 10-Freeze-dried material transfer mechanism, 100-First feeding and conveying assembly, 200-Second feeding and conveying assembly, 210-First drive mechanism, 220-Second drive mechanism, 230-First screw, 240-Second screw, 241-First feeding position, 242-Second feeding position, 300-Pick-and-place assembly, 310-Pick-and-place component, 320-Drive component, 321-Rotation drive component, 322-Lifting drive component, 330-Fixed frame, 340-Connector, 350-Central shaft, 360-Air slip ring, 370-Bracket, 400-Freeze-drying mold collection tray, 500-Second detection mechanism, 600-Detection mechanism, A-First pick-and-place unit, B-Second pick-and-place unit, C-Third pick-and-place unit, D-Fourth pick-and-place unit.

[0069] 20-Pharmaceutical container supply unit, 21-Unpacking mechanism, 22-Sealing paper heating mechanism, 23-Paper picking mechanism, 24-Crater picking mechanism, 25-Pharmaceutical container picking mechanism.

[0070] 30-Freeze-dried material supply unit, 31-Freeze-drying mold feeding mechanism, 32-Front weighing mechanism, 33-Freeze-dried material filling mechanism, 34-Rear weighing mechanism, 35-Freeze-drying feeding mechanism, 36-Freeze-drying mechanism, 37-Capping mechanism.

[0071] 40-Filling unit, 41-First sealing mechanism, 42-Filling mechanism, 43-Second sealing mechanism, 44-First detection mechanism, 45-First flipping mechanism, 46-Freeze-dried material pre-loading machine, 47-Third sealing mechanism.

[0072] 50 - Discharge unit, 51 - Adapter mounting mechanism, 52 - Top cap mounting mechanism, 53 - Pharmaceutical container flipping mechanism, 54 - Back push mounting mechanism, 55 - Discharge mechanism.

[0073] 60 - Pharmaceutical containers.

[0074] 70 - Control device for dual-chamber pre-filled syringe production line; 71 - Processor; 72 - Memory. Detailed Implementation

[0075] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. Based on the embodiments of this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application. In addition, it should be understood that the specific embodiments described herein are only for illustration and explanation of this application and are not intended to limit this application. In this application, unless otherwise stated, directional terms such as "up," "down," "left," and "right" generally refer to up, down, left, and right in the actual use or working state of the device, specifically the drawing directions in the accompanying drawings.

[0076] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Thus, a feature defined with "first" or "second" may explicitly or implicitly include at least one of that feature.

[0077] This application provides a freeze-dried material transfer mechanism, a dual-chamber pre-filled syringe production line, a production method, a control device, and a storage medium, which are described in detail below. It should be noted that the order of description of the following embodiments is not intended to limit the preferred order of the embodiments of this application. Furthermore, in the following embodiments, the descriptions of each embodiment have their own emphasis; parts not described in detail in a certain embodiment can be referred to in the relevant descriptions of other embodiments.

[0078] Please see Figure 1 The embodiments of this application provide a freeze-dried material transfer mechanism 10, which includes a first feeding and conveying assembly 100, a second feeding and conveying assembly 200, and a pick-and-place assembly 300.

[0079] The first feeding and conveying assembly 100 is used to feed the pharmaceutical container 60. For example, the pharmaceutical container 60, after being flipped by the first flipping mechanism 45, is conveyed by the first feeding and conveying assembly 100 to one side of the pick-and-place assembly 300. Details about the first flipping mechanism 45 will be described later. Of course, it is understood that without the first flipping mechanism 45, the first feeding and conveying assembly 100 can simply convey the pharmaceutical container 60 from upstream to one side of the pick-and-place assembly 300. The first feeding and conveying assembly 100 may include a conveyor line, etc.

[0080] The second feeding and conveying assembly 200 is used to feed freeze-dried materials and may include a conveyor line, etc. For example, it conveys freeze-dried materials from the freeze-dried material supply unit 30 to one side of the pick-and-place assembly 300. The details of the freeze-dried material supply unit 30 will be described later.

[0081] Here, exemplarily, the first feeding conveyor assembly 100 and its conveying direction are arranged parallel to the conveying direction of the second feeding conveyor assembly 200. Figure 1 In the illustrated state, the conveying direction of both is from left to right. The first feeding conveyor assembly 100 and the second feeding conveyor assembly 200 are located on both sides of the pick-and-place assembly 300 to save space and facilitate the pick-and-place assembly 300 in filling the freeze-dried material into the pharmaceutical container 60. Of course, this embodiment is not intended to unduly limit the scope of the invention. In other embodiments, the first feeding conveyor assembly 100 and the second feeding conveyor assembly 200 may be located in other positions, such as on the same side of the pick-and-place assembly 300 or on adjacent sides of the pick-and-place assembly 300.

[0082] Please see here. Figure 2 The second feeding and conveying assembly 200 includes a first screw 230 and a second screw 240 arranged coaxially. (See also...) Figure 3 The second feeding and conveying assembly 200 also includes a first drive mechanism 210 and a second drive mechanism 220. The first drive mechanism 210 is driven to the first screw 230, and the second drive mechanism 220 is driven to the second screw 240. The first screw 230 and the second screw 240 are arranged adjacent to each other along the conveying direction of the second feeding and conveying assembly 200 to realize the function of screw conveying. The first drive mechanism 210 and the second drive mechanism 220 can be mounted on a fixed bracket 330. Here, by way of example, a transfer conveyor line can also be provided upstream of the first screw 230 to feed material to the first screw 230.

[0083] Specifically, taking the first screw 230 as an example, a receiving position for accommodating freeze-dried material is formed between two adjacent blades of the first screw 230. Driven by the first drive mechanism 210, the first screw 230 rotates at a set angle, causing the freeze-dried material to move forward one stroke, thereby realizing the spiral conveying of the freeze-dried material. Similarly, a receiving position for accommodating freeze-dried material is also formed between two adjacent blades of the second screw 240. Driven by the second drive mechanism 220, the second screw 240 rotates at a set angle, causing the freeze-dried material to move forward one stroke, thereby realizing the spiral conveying of the freeze-dried material. In essence, it splits a spiral conveying rod into a first screw 230 and a second screw 240 arranged in succession.

[0084] Therefore, with the first screw 230 and the second screw 240 rotating synchronously, the freeze-dried material can be continuously conveyed forward. In some cases, if the number of rotations of the first screw 230 and the second screw 240 is adjusted so that the number of rotations of the second screw 240 is greater than the number of rotations of the first screw 230, differential conveying can be achieved to coordinate with the subsequent pick-and-place assembly 300 to move the freeze-dried material.

[0085] For example, if the rotation frequency of the second screw 240 is set to twice that of the first screw 230, then one rotation of the first screw 230 will move one portion of freeze-dried material forward by one stroke and deliver it to the second screw 240. Meanwhile, the second screw 240 will rotate two rotations to move the previous portion of freeze-dried material at its original position forward by two strokes. Thus, an empty receiving position is formed between the previous portion of freeze-dried material and the current portion of freeze-dried material.

[0086] In this embodiment, the second screw 240 of the second feeding and conveying assembly 200 includes two feeding positions, which can be any two receiving positions of the second screw 240 for receiving freeze-dried materials. For example, they can be two receiving positions for receiving freeze-dried materials formed between the three blades at the end of the second screw 240 furthest from the second screw 240.

[0087] Please see Figure 4 In this embodiment, the two feeding positions are defined as the first feeding position 241 and the second feeding position 242. The first feeding position 241 is located downstream of the second feeding position 242, that is, the first feeding position 241 is located on the side of the second feeding position 242 away from the first screw 230. Thus, by controlling the number of rotations of the second screw 240 and the first screw 230, the second screw 240 can have four feeding states, namely the first feeding state, the second feeding state, the third feeding state, and the fourth feeding state.

[0088] In the first feeding state, both the first feeding position 241 and the second feeding position 242 contain freeze-dried material. For example, this can be achieved by making the number of rotations of the second screw 240 and the first screw 230 the same when feeding two adjacent freeze-dried materials.

[0089] Please see Figure 5 In the second feeding state, the first feeding position 241 does not have freeze-dried material, while the second feeding position 242 has freeze-dried material. For example, this can be achieved by rotating the second screw 240 one more revolution than the first screw 230 before feeding a freeze-dried material to the second screw 240.

[0090] Please see Figure 6 In the third feeding state, the first feeding position 241 has freeze-dried material, while the second feeding position 242 does not. For example, this can be achieved by feeding a freeze-dried material to the second screw 240, and then rotating the second screw 240 one more revolution than the first screw 230.

[0091] Please see Figure 7In the fourth feeding state, neither the first feeding position 241 nor the second feeding position 242 contains freeze-dried material. For example, this can be achieved by rotating the second screw 240 one revolution while the first screw 230 remains stationary.

[0092] It is understood that this embodiment is illustrated using the example of the second screw 240 having two feeding positions, but the second screw 240 itself may have more feeding positions for containing freeze-dried materials. Furthermore, in other embodiments, the second screw 240 may also have other numbers of feeding positions, such as three, four, or five. And in other embodiments, the second screw 240 may not have a fourth feeding state, etc. The examples in this embodiment do not constitute undue limitation.

[0093] In this embodiment, please refer to again Figure 1 The pick-and-place assembly 300 includes at least one set of pick-and-place units, and each set of pick-and-place units includes at least one pick-and-place element 310. For example, the pick-and-place assembly 300 has four sets of pick-and-place units, namely a first set of pick-and-place units A, a second set of pick-and-place units B, a third set of pick-and-place units C, and a fourth set of pick-and-place units D. The four sets of pick-and-place units are evenly arranged along the circumference, that is, the included angle between two adjacent sets of pick-and-place units is approximately a right angle.

[0094] Here, the position and number of pick-and-place components 310 in each pick-and-place unit correspond to the loading positions of the second screw 240. For example, the following explanation assumes the second screw 240 has two loading positions, and the number of pick-and-place components 310 in each pick-and-place unit is also two, corresponding to the positions of the two loading positions of the second screw 240. That is, the two pick-and-place components 310 are arranged sequentially along the loading position setting direction and can be used to simultaneously pick up and place the freeze-dried material at the two loading positions. It can be understood that when the number of loading positions is three, four, five, etc., the number of pick-and-place components 310 in each pick-and-place unit is correspondingly three, four, five, etc.

[0095] Please see Figure 8 The pick-and-place assembly 300 also includes a rotary drive 321, which is driveably connected to the pick-and-place unit to drive the pick-and-place member 310 of the pick-and-place unit to rotate. The rotary drive assembly can be a motor, etc., and can be driveably connected to the pick-and-place assembly 300 via a reduction gearbox, bevel gear transmission mechanism, etc. Thus, the pick-and-place unit can be driven to rotate via the rotary drive 321. It is understood that in... Figure 2 and Figure 8 In order to facilitate observation of the relative positional relationship between the pick-up and drop-off component 310 and the pharmaceutical container 60, the first feeding and conveying assembly 100 is not shown.

[0096] Here, the pick-and-place assembly 300 has four stations: a first station, a second station, a third station, and a fourth station. When the pick-and-place assembly 300 is driven to rotate by the rotary drive 321, each pick-and-place unit can rotate and switch between the four stations. For example, the first, second, third, and fourth stations are arranged evenly along the circumference, meaning the angle between any two adjacent stations is approximately 90 degrees. Of course, in other embodiments, the arrangement of the four stations may differ according to actual needs, and this embodiment does not constitute an undue limitation.

[0097] Here, the movement process of each set of pick-and-place units is the same. In this embodiment, the movement process of one set of pick-and-place units will be used as an example for illustrative explanation.

[0098] At the first station, the pick-and-place unit 310 of a set of pick-and-place units corresponds to the loading position of the second screw 240, and the pick-and-place unit 310 can remove the freeze-dried material at the loading position. For example, the pick-and-place unit 310 is a vacuum adsorption unit, which picks up the freeze-dried material at the loading position by vacuum adsorption. Exemplarily, Figure 1 The location of the first pick-and-place unit A is the location of the first workstation.

[0099] At the second workstation, a second detection mechanism 500 is provided. This second detection mechanism 500 is used to detect whether the pick-and-place unit 310 has acquired freeze-dried material. Here, the second detection mechanism 500 can be a visual detection mechanism such as a camera; of course, in other embodiments, it can also be other infrared detection mechanisms, etc., and this embodiment does not constitute an undue limitation. Furthermore, exemplarily, this group of pick-and-place units can rotate approximately 90 degrees from the previous state to move from the first workstation to the second workstation. Again, exemplarily... Figure 1 The location of the second pick-and-place unit B is the location of the second workstation.

[0100] At the third station, the set of pick-and-place units moves to a position corresponding to the first feeding conveyor assembly 100 and aligns with the position of the pharmaceutical containers 60 on the first feeding conveyor assembly 100, for example, moving to the upper side of the first feeding conveyor assembly 100. The arrangement of the pharmaceutical containers 60 on the first feeding conveyor assembly 100, the arrangement of the feeding positions of the second feeding conveyor assembly 200, and the arrangement of the pick-and-place components 310 in each set of pick-and-place units correspond to each other. Thus, when rotating to the third station, the pick-and-place components 310 of this set of pick-and-place units can place the freeze-dried material into the corresponding pharmaceutical container 60. Furthermore, by way of example, this set of pick-and-place units can rotate approximately 90 degrees from the previous state to rotate from the second station to the third station. Again by way of example, Figure 1 The location of the third pick-and-place unit C is the location of the third workstation.

[0101] The fourth workstation is a cleaning station. For example, Figure 1 The location of the fourth pick-and-place unit D is the fourth workstation. Here, because freeze-dried material particles may fall off, the pick-and-place component 300 may become contaminated with some of these particles. This contamination could potentially cause the freeze-dried material particles to adhere to subsequent freeze-dried materials, affecting their quality. In particular, when the pick-and-place component 310 is a vacuum adsorption component, the freeze-dried material particles may continue to accumulate and block the airflow path in the vacuum adsorption system.

[0102] Therefore, at the fourth station, the set of pick-and-place units will be cleaned. For example, when the pick-and-place component 310 is a vacuum adsorption component, the air path is cleaned by controlling the pick-and-place component 310 to spray air outwards. Exemplarily, a collection container can also be provided at the fourth station, and the pick-and-place component 310 of the set of pick-and-place units can be moved to a position corresponding to the collection container and spray air to spray extruded materials such as freeze-dried material particles into the collection container. Of course, in other embodiments, the cleaning station can also be provided with other structures and other methods for cleaning, such as providing a reciprocating brush to clean the pick-and-place component 310, or providing a high-pressure nozzle and drying equipment to clean and dry with high-pressure liquid, etc. The examples in this embodiment do not constitute an undue limitation.

[0103] It is understood that four sets of pick-and-place units and four workstations are provided here. In actual operation, each workstation has one set of pick-and-place units working, thereby ensuring the continuity of the pick-and-place component 300's operation and improving work efficiency. However, in other embodiments, the number of pick-and-place units and workstations may not correspond, for example, only one set, two sets, or other numbers of pick-and-place units may be provided. Furthermore, the above example using four workstations is provided for illustration. In other embodiments, only the first and third workstations may be provided, or the fourth workstation may not be provided, etc. The examples in this embodiment do not constitute an undue limitation on this application.

[0104] It is understood that this embodiment is illustrated using a rotary drive unit 321 as an example. However, in other embodiments, the rotary drive unit 321 can be replaced with other linear displacement drive units, curved displacement drive units, or other drive units 320, as long as the drive unit 320 can drive the pick-and-place unit 310 of the pick-and-place unit to move between the first feeding conveyor assembly 100 and the second feeding conveyor assembly 200 to feed the freeze-dried material into the pharmaceutical container 60. The example in this embodiment does not constitute an undue limitation. Furthermore, the above embodiment uses the drive unit 320 driving each group of pick-and-place units as an example for illustration. In other embodiments, the drive unit 320 can also drive each pick-and-place unit 310. The example in this embodiment does not constitute an undue limitation.

[0105] In addition, please refer to Figure 8 The drive unit 320 of the freeze-dried material transfer mechanism 10 may also include a lifting drive unit 322, which is connected to the pick-and-place unit and is used to drive the pick-and-place unit 310 to lift.

[0106] For example, a connector 340 may be provided, and the pick-and-place assembly 300 is disposed on the connector 340. The connector 340 may be an integral structure or a structure formed by connecting several connecting blocks. The lifting drive 322 may be a motor or a telescopic cylinder, etc. For example, when the lifting drive 322 is a motor, it is connected to a reduction gearbox and a lead screw in sequence to transmit power to the connector 340, so as to drive the connector 340 and the pick-and-place assembly 300 thereon to move up and down in a roughly vertical direction; or, for example, when the lifting drive 322 is a telescopic cylinder, it is directly or indirectly connected to the connector 340, so as to drive the connector 340 and the pick-and-place assembly 300 thereon to move up and down in a roughly vertical direction. Of course, in other embodiments, the lifting drive 322 may also be of other structures, and the lifting drive 322 may also be directly or indirectly connected to the pick-and-place assembly 300 in other ways, as long as it can drive the pick-and-place assembly 300 to lift. For example, the lifting drive 322 may include telescopic cylinders provided for each pick-and-place member 310 or each group of pick-and-place units. The examples in this embodiment do not constitute an undue limitation.

[0107] Therefore, the lifting drive 322 can drive the pick-and-place member 310 to move up and down. For example, when the pick-and-place member 310 is at the first station, it is driven to move down to pick up the freeze-dried material, and then moves up to reset. Or, when the pick-and-place member 310 is at the third station, it is driven to move down to put down the freeze-dried material, and then moves up to reset. Of course, when lifting is not required, the lifting drive 322 may not be provided, and the example in this embodiment does not constitute an undue limitation.

[0108] Furthermore, at the second or fourth workstation, the pick-and-place unit 310 can be moved to the desired corresponding position via lifting, such as the detection position at the second workstation or the cleaning position at the fourth workstation. Of course, in other embodiments, the detection position at the second workstation and the cleaning position at the fourth workstation can also be set at the position before descent, and the example in this embodiment does not constitute an undue limitation.

[0109] Here, for example, please refer to Figure 8 The pick-and-place assembly 300 has a central shaft 350, the pick-and-place unit is connected to the central shaft 350, and the central shaft 350 is rotatably connected to the connector 340 and is drively connected to the rotary drive 321. The lifting drive 322 is mounted on a fixed frame 330 and is directly or indirectly connected to the pick-and-place unit, for example, the lifting drive 322 connects to the connector 340. When the lifting drive 322 drives the connector 340 to rise or fall, the rotary drive 321 and the pick-and-place unit are also driven to rise or fall. Here, the aforementioned first drive mechanism 210 and second drive mechanism 220 can also be mounted on the fixed frame 330. It is understood that in other embodiments, the first drive mechanism 210, the second drive mechanism 220, and the lifting drive 322 can also be mounted on different fixed frames 330, and this embodiment does not impose undue limitations on them.

[0110] Of course, in other embodiments, the rotary drive 321 can be connected to the connector 340 to drive the connector 340 to rotate as a whole, while the lifting drive 322 is disposed on the connector 340. The pick-and-place assembly 300 is connected to the lifting drive 322 and can be lifted and lowered to the connector 340, which can also achieve similar technical effects. The example in this embodiment does not constitute an undue limitation.

[0111] The coordinated arrangement of the rotary drive component 321 and the lifting drive component 322 achieves a compact structural design, which helps reduce the overall space occupied and improves work efficiency. In particular, the arrangement of the rotary drive component 321 and the four workstations evenly distributed along the circumference effectively improves its work efficiency.

[0112] In an embodiment where a rotary drive 321 is provided and the pick-and-place component 310 is a vacuum adsorption component, the pick-and-place assembly 300 has a central shaft 350, and a slip ring 360 is provided on the central shaft 350 and connected to a bracket 370 through the slip ring 360. A vacuum source is connected to the slip ring 360 through a gas pipeline, and the slip ring 360 is connected to each vacuum adsorption component through a gas pipeline to provide positive or negative pressure to each vacuum adsorption component. The vacuum source can be a pump, etc. The slip ring 360 enables gas flow communication during rotation. The slip ring 360 is a structure used to achieve gas flow sealing and communication, which is prior art in the field of gas flow communication, and will not be described in detail in this embodiment.

[0113] Here, vacuum adsorption can be used to effectively and conveniently pick up, place, and move freeze-dried materials, thereby improving the pre-loading efficiency of freeze-dried materials without damaging them, which helps to ensure the quality of freeze-dried material loading.

[0114] In some embodiments, to improve the alignment of the connector 340 and the pick-and-place assembly 300 during lifting and lowering, a guide post and a guide sleeve may be provided. The fixed frame 330 does not move with the lifting drive 322 and the rotation drive 321. One of the guide post and the guide sleeve is connected to the fixed frame 330, and the other is connected to the connector 340. The guide post is fitted within the guide sleeve and extends along the lifting and lowering direction of the connector 340, which is typically approximately vertical. Thus, when the lifting drive 322 drives the connector 340 to lift and lower, the guide post also lifts and lowers accordingly, and achieves a guiding function based on its cooperation with the guide sleeve, thereby making the lifting and lowering of the connector 340 and the pick-and-place assembly 300 more stable and aligned.

[0115] In some embodiments, please refer to Figure 8 and Figure 9 A detection mechanism 600 can also be provided, which can be used to detect whether the liquid in the pharmaceutical container 60 meets a preset standard. For example, the detection mechanism 600 can be a liquid weighing mechanism, a visual inspection mechanism, etc., used to detect whether the weight of the liquid meets a preset standard or whether the liquid level meets a standard. Exemplarily, the detection result of the detection mechanism 600 can be used to control the second feeding and conveying mechanism. Here, the detection mechanism 600 can be set at the freeze-dried material transfer mechanism 10. If the freeze-dried material transfer mechanism 10 is applied in a production line or other structure, the detection mechanism 600 can also be set at other positions upstream of the freeze-dried material transfer mechanism 10.

[0116] Therefore, if the liquid in a pharmaceutical container 60 does not meet the preset standard according to the test results of the testing agency, the corresponding pharmaceutical container 60 will not be fed with freeze-dried material. For example, if two consecutive pharmaceutical containers 60 meet the standard, the second feeding conveyor is controlled to be in the first feeding state; if the previous pharmaceutical container 60 does not meet the standard but the next pharmaceutical container 60 does, the second feeding conveyor is controlled to be in the aforementioned second feeding state; if the previous pharmaceutical container 60 meets the standard but the next pharmaceutical container 60 does not, the second feeding conveyor is controlled to be in the aforementioned third feeding state; if two consecutive pharmaceutical containers 60 do not meet the standard, the second feeding conveyor is controlled to be in the fourth feeding state.

[0117] This setup effectively ensures that only compliant pharmaceutical containers 60 are dispensed with freeze-dried material, while non-compliant containers 60 can be more conveniently disposed of in the waste collection area at subsequent workstations, reducing waste of the freeze-dried material. For example, at a subsequent workstation, non-compliant pharmaceutical containers 60 can be picked up by robotic arms or moved to the waste collection area via conveyor lines.

[0118] In some embodiments, since the freeze-dried material is placed in the freeze-drying mold and fed, in order to collect the empty freeze-drying mold after the freeze-drying material is fed, a freeze-drying mold collection tray 400 can also be provided at the end of the second feeding conveying mechanism. The second feeding conveying mechanism can transport the empty freeze-drying mold to the freeze-drying mold collection tray 400.

[0119] Accordingly, in order to better achieve the technical effects of the embodiments of this application, the embodiments of this application also provide a dual-chamber pre-filled syringe production line. Please refer to... Figure 10 The dual-chamber pre-filled syringe production line includes a pharmaceutical container supply unit 20, a freeze-dried material supply unit 30, a filling unit 40, and a discharging unit 50. Of course, in some embodiments, it may only include the filling unit 40.

[0120] The pharmaceutical container supply unit 20 and the freeze-dried material supply unit 30 are both located upstream of the filling unit 40, and the discharge unit 50 is located downstream of the filling unit 40.

[0121] The pharmaceutical container supply unit 20 supplies pharmaceutical containers 60 to the filling unit 40, and the lyophilized material supply unit 30 supplies lyophilized material to the filling unit 40. The filling unit 40 is used to fill the pharmaceutical containers 60, for example, by filling the pharmaceutical containers 60 with liquid components and by filling the lyophilized material into the pharmaceutical containers 60. The dispensing unit 50 is used to assemble the pharmaceutical containers 60, pre-filled with liquid components and lyophilized material, into a syringe and then dispense the material.

[0122] In some embodiments, the pharmaceutical container supply unit 20 may also be used to unpack the outer packaging containing the pharmaceutical container 60 to remove the pharmaceutical container 60 from the outer packaging.

[0123] For example, the syringe supply unit includes an unpacking mechanism 21, a sealing paper heating mechanism 22, a paper dispensing mechanism 23, a nesting plate dispensing mechanism 24, and a medicine dispensing container mechanism 25 arranged in sequence.

[0124] The pharmaceutical container 60 is typically housed within an outer packaging, which includes an outermost bag or box containing a honeycomb-shaped container with several compartments arranged in an array. Each compartment contains one pharmaceutical container 60. The honeycomb box has a honeycomb board that substantially covers it, and a sealing paper may also be placed on the honeycomb board.

[0125] In use, the unpacking mechanism 21 first removes the outer packaging bag or box to take out the nest box. Then, the sealing paper heating mechanism 22 heats the sealing paper to facilitate the paper-removing mechanism tearing the sealing paper off the nest box. After the sealing paper is torn off, the nest board removal mechanism 24 removes the nest board, thereby exposing the medicine container 60 inside the nest box. The medicine container removal mechanism 25 can then remove the medicine container 60 from the nest box.

[0126] The unpacking mechanism 21, the sealing paper heating mechanism 22, the paper taking mechanism 23, the nesting board taking mechanism 24, and the medicine container taking mechanism 25 can be mechanisms including robotic arms. Of course, existing mechanisms can also be used. For example, the unpacking mechanism 21 can be an existing automatic unpacking machine or semi-automatic unpacking machine. This is something that those skilled in the art can choose according to actual needs. The examples in this embodiment do not constitute an undue limitation.

[0127] Here, depending on actual needs, any of the unpacking mechanism 21, sealing paper heating mechanism 22, paper picking mechanism 23, and nesting board picking mechanism 24 may be omitted. For example, when it is not necessary to remove the packaging bag or box, the unpacking mechanism 21 may be omitted. Without the unpacking mechanism 21, sealing paper heating mechanism 22, paper picking mechanism 23, and nesting board picking mechanism 24, the pharmaceutical container supply unit 20 can essentially only perform the operation of supplying the pharmaceutical container 60 to the filling unit 40. Other operational steps can be performed manually or pre-completed by other equipment. It is understood that the examples in this embodiment do not constitute an undue limitation on this application.

[0128] The freeze-dried material supply unit 30 is used to supply freeze-dried material to the filling unit 40. Here, in some embodiments, the freeze-dried material supply unit 30 can also be used to prepare the freeze-dried material.

[0129] For example, the freeze-dried material supply unit 30 may include a feeding subunit and a freeze-drying subunit.

[0130] Please continue reading for more details. Figure 10 The feeding subunit may include a freeze-drying mold feeding mechanism 31, a front weighing mechanism 32, a freeze-drying material filling mechanism 33, and a rear weighing mechanism 34.

[0131] The freeze-drying mold feeding mechanism 31 is used to feed the freeze-drying mold, which is subsequently used to contain freeze-dried materials. After the freeze-drying mold is fed, the front weighing mechanism 32 first weighs it, and then the freeze-drying material filling mechanism 33 fills the freeze-drying mold with freeze-dried materials. After the freeze-drying material is filled, the rear weighing mechanism 34 weighs the freeze-drying mold containing the freeze-dried materials.

[0132] Here, the difference between the data weighed by the rear weighing mechanism 34 and the data weighed by the front weighing mechanism 32 is the weight of the filled liquid. If this difference does not meet the preset weight range, the corresponding freeze-drying mold will be rejected before freeze-drying. For example, the processor 71 of the dual-chamber pre-filled syringe production line records the position number of the freeze-drying mold that does not meet the requirements. When the freeze-drying mold is transported to the rejection station downstream of the rear weighing mechanism 34, the robot or other structure at the rejection station removes the freeze-drying mold from the production line.

[0133] For freeze-drying molds that meet the weighing requirements, they are transported to the freeze-drying subunit for freeze-drying operation.

[0134] Of course, in other embodiments, depending on actual needs, any of the freeze-drying mold feeding mechanism 31, the front weighing mechanism 32 and the rear weighing mechanism 34 may not be provided. The example in this embodiment does not constitute an undue limitation on them.

[0135] Furthermore, the freeze-drying mold feeding mechanism 31 can be a material feeding tray, etc., and the filling mechanism 42 can be a filling pump, etc. Of course, the example in this embodiment does not constitute an undue limitation, and other structures can be used to achieve the corresponding functions in other embodiments.

[0136] Please continue reading. Figure 10 The freeze-drying subunit includes a freeze-drying feeding mechanism 35, a freeze-drying mechanism 36, and a capping mechanism 37.

[0137] The aforementioned freeze-drying mold filled with freeze-dried material is transported to the freeze-drying feeding mechanism 35, which can be a push rod mechanism or the like, and sends the freeze-drying mold into the freeze-drying mechanism 36 for freeze-drying.

[0138] The freeze-drying mechanism 36 can be a freeze dryer or the like. The freeze-dried material is roughly in the shape of solid chalk, which can be called a powder cake. Of course, this embodiment does not limit its shape. After the freeze-drying operation is completed, the freeze-dried material and the freeze-dried mold containing it can be transferred to the filling unit 40 for subsequent operations.

[0139] Here, the capping mechanism 37 does not participate in the operation, so in some embodiments, it may not be provided. However, in other embodiments, the capping mechanism 37 may be provided to improve the applicability of the dual-chamber pre-filled syringe production line. Thus, the dual-chamber pre-filled syringe production line can also be used to produce other products. For example, vials or other containers are fed through the freeze-drying mold feeding mechanism 31, and the freeze-dried material filling mechanism 33 fills the vials or other containers with liquid medicine. Then, the vials or other containers filled with liquid medicine are sent to the capping mechanism 37 for capping operation for storage and transfer.

[0140] It is understood that in other embodiments, depending on the actual situation, either the feeding subunit or the freeze-drying subunit may not be provided. For example, freeze-drying operations can be performed by other equipment. In this case, the dual-chamber pre-filled syringe production line does not have a feeding subunit or a freeze-drying subunit. The dual-chamber pre-filled syringe production line itself may not have a freeze-drying function; it may only be used to feed the freeze-dried material to the filling unit 40. The above examples of this embodiment do not constitute an undue limitation on this application.

[0141] Please continue reading here. Figure 10 The filling unit 40 is used to fill the liquid component into the pharmaceutical container 60 and to fill the lyophilized material into the pharmaceutical container 60.

[0142] For example, the filling unit 40 includes a liquid filling subunit and a freeze-dried material pre-filling subunit.

[0143] The liquid filling subunit includes a first sealing mechanism 41, a filling mechanism 42, and a second sealing mechanism 43 arranged in sequence.

[0144] The first sealing mechanism 41 is used to add a first sealing body into the pharmaceutical container 60, the filling mechanism 42 is used to fill the space above the first sealing body with liquid, such as diluent, and the second sealing mechanism 43 is used to add a second sealing body into the pharmaceutical container 60. A liquid chamber for sealing the diluent is formed between the first and second sealing bodies. It can be understood that for a dual-chamber pre-filled syringe, one end of its connecting channel is connected to this liquid chamber.

[0145] Here, the first sealing body and the second sealing body can be the same or different. For example, both the first sealing body and the second sealing body can be rubber stoppers. Of course, in other embodiments, other structures can be used, such as wooden stoppers or metal stoppers, as long as they can form a liquid chamber to contain the liquid. The examples in this embodiment do not constitute an undue limitation.

[0146] In some embodiments, a first detection mechanism 44 may be provided, which is used to detect whether the filling volume of the liquid meets a preset standard. The first detection mechanism 44 may be located on the same side, opposite side, or downstream of the filling mechanism 42, as long as it can detect the filling volume of liquid. For example, the first detection mechanism 44 may include two liquid weighing mechanisms, which are respectively located upstream and downstream of the filling mechanism 42, and weighing is performed before and after filling to obtain the filling volume, etc. The examples in this embodiment do not constitute an undue limitation. In addition, in some embodiments, the detection result of the first detection mechanism 44 can be used to control the downstream freeze-dried material pre-filling subunit. For example, the first detection mechanism 44 is used as the aforementioned detection mechanism of the freeze-dried material transfer mechanism 10. Of course, in other embodiments, another detection mechanism may be provided at the freeze-dried material transfer mechanism 10, and the detection mechanism may also be a liquid weighing mechanism or other mechanisms.

[0147] It is understandable that the liquid filling subunit may not be equipped with the first sealing mechanism 41, for example, when the pharmaceutical container 60 supplied to the liquid filling subunit is already equipped with the first sealing body.

[0148] Please continue reading. Figure 10 The freeze-dried material preloading subunit includes a first flipping mechanism 45, a freeze-dried material preloading machine 46, and a third sealing mechanism 47 arranged sequentially. The freeze-dried material preloading machine 46 can be the freeze-dried material transfer mechanism 10 described in the previous embodiments, the structure of which has been specifically described in the previous embodiments and will not be repeated in this embodiment.

[0149] The first flipping mechanism 45 is used to flip the pharmaceutical container 60 so that the side of the pharmaceutical container 60 used for pre-filling the freeze-dried material faces the freeze-dried material transfer mechanism 10. For example, the first flipping mechanism 45 is a robotic arm. Of course, in some embodiments, the first flipping mechanism 45 may not be provided if it is not necessary to flip the pharmaceutical container 60.

[0150] Here, the freeze-dried material transfer mechanism 10 is located downstream of the liquid filling subunit. Of course, in other embodiments, it can also be located upstream of the liquid filling subunit.

[0151] It is understood that in other embodiments, the filling unit 40 may also be used to fill the lyophilized material into the pharmaceutical container 60, rather than to fill the pharmaceutical container 60 with liquid components, for example, when the pharmaceutical container supply unit 20 supplies the pre-transfer unit with a pharmaceutical container 60 that has already been filled with liquid components. The example in this embodiment does not constitute an undue limitation on this.

[0152] Here, as previously stated, a third sealing mechanism 47 is also provided downstream of the lyophilized material transfer mechanism 10. The third sealing mechanism 47 is used to provide a third sealing body in the pharmaceutical container 60 for sealing the lyophilized material. In an embodiment with a first flipping mechanism 45, a chamber for containing the lyophilized material is formed between the first and third sealing bodies. It is understood that for a dual-chamber pre-filled syringe, one end of its connecting channel is connected to the liquid chamber, and the other end is also connected to the liquid chamber.

[0153] Here, the third sealing body can be a rubber stopper, etc. Of course, in other embodiments, it can also adopt other structures, such as wooden stoppers, metal stoppers, etc., as long as it can form a chamber to contain the freeze-dried material. The example in this embodiment does not constitute an undue limitation.

[0154] In some embodiments, as described above, for a dual-chamber prefilled syringe, its pharmaceutical container 60 has a liquid chamber for containing liquid and a chamber for containing lyophilized material. Before the dual-chamber prefilled syringe is used, the two chambers are not connected; otherwise, the lyophilized material will be mixed with the liquid prematurely without needing to do so, thus preventing it from achieving its intended function.

[0155] To this end, the dual-chamber pre-filled syringe production line is also equipped with a third inspection mechanism. This third inspection mechanism is located downstream of the freeze-dried material transfer mechanism 10 and upstream of the third sealing mechanism 47, and is used to detect the communication status between the liquid chamber for containing liquid and the chamber for containing freeze-dried material within the pharmaceutical container 60. If the third inspection mechanism detects that the two chambers of the pharmaceutical container 60 are pre-connected, the pharmaceutical container 60 will be removed as a defective product at a subsequent station. This improves the yield rate of the dual-chamber pre-filled syringes. Here, the third inspection mechanism can be a visual inspection mechanism, an infrared inspection mechanism, etc., and the example in this embodiment does not constitute an undue limitation.

[0156] In some embodiments, to improve environmental cleanliness, a laminar flow hood is provided. Both the liquid filling subunit and the freeze-dried material pre-loading subunit are housed within the laminar flow hood and operate under a Class A laminar flow environment. The Class A laminar flow airflow moves from the liquid filling subunit to the freeze-dried material pre-loading subunit. Since this embodiment places the liquid filling subunit upstream of the freeze-dried material pre-loading subunit, it better ensures product yield. Conversely, if the freeze-dried material pre-loading subunit is placed upstream of the liquid filling subunit, the freeze-dried material particles are prone to detachment, especially under Class A laminar flow conditions. These particles are easily stirred up by the Class A laminar flow, forming dust contamination, and easily fall into the downstream liquid, leading to a decrease in product yield.

[0157] Please continue reading here. Figure 10 The dispensing unit 50 receives the pharmaceutical container 60 from the filling unit 40. At this time, the pharmaceutical container 60 is pre-filled with liquid components and lyophilized material. The liquid component can be a diluent, and the lyophilized material can be a powder. Then, the dispensing unit 50 assembles the pharmaceutical container 60 pre-filled with liquid components and lyophilized material into a syringe and dispenses the liquid.

[0158] For example, the discharge unit 50 may include an adapter mounting mechanism 51, a top cap mounting mechanism 52, a pharmaceutical container flipping mechanism 53, a back-pushing mounting mechanism 54, and a discharge mechanism 55.

[0159] The pharmaceutical container 60 has a first end and a second end. The adapter mounting mechanism 51 first mounts the adapter to the first end of the syringe, the adapter acting as an adapter. Then, the cap mounting mechanism 52 mounts a cap onto the adapter for protection.

[0160] Subsequently, the pharmaceutical container 60 is flipped 180° by the flipping structure, reversing the positions of the first and second ends of the pharmaceutical container 60. The back-push mounting mechanism 54 can install the back pusher at the second end of the pharmaceutical container 60. The back pusher is a flange structure protruding outward at the second end of the pharmaceutical container 60. When actually using the syringe, the operator can press the front of the back pusher with their index and middle fingers and press the plunger with their thumb to inject. After the back pusher is installed, the pharmaceutical container 60 becomes a syringe without a plunger and needle, and the dispensing mechanism 55 can dispense it into the finished product collection container.

[0161] The adapter mounting mechanism 51, the top cap mounting mechanism 52, the pharmaceutical container flipping mechanism 53, the back push mounting mechanism 54, and the discharge mechanism 55 can be structures including a robotic arm, or other structures, such as a discharge star wheel.

[0162] It is understood that in other embodiments, the dispensing unit 50 may not include any of the adapter mounting mechanism 51, top cap mounting mechanism 52, pharmaceutical container flipping mechanism 53, and back-push mounting mechanism 54. For example, if the second end of the pharmaceutical container 60 does not require a separate back-push mechanism, the pharmaceutical container flipping mechanism 53 and the back-push mounting mechanism 54 may not be provided. Alternatively, the position of the back-push mounting structure can be adjusted, thereby eliminating the need for the pharmaceutical container flipping mechanism 53 and the flipping of the pharmaceutical container 60. Furthermore, existing syringe manufacturing production lines typically possess structures capable of implementing adapter mounting, top cap mounting, and back-push mounting; these structures can be used to achieve the corresponding functions, and the dual-lumen pre-filled syringe production line itself may not have these functions. In conclusion, the examples in this embodiment do not constitute undue limitations.

[0163] Furthermore, in some embodiments, the dual-chamber pre-filled syringe production line may also be equipped with a mesh belt conveyor or other conveyor lines, etc., to facilitate material transport between units and / or between mechanisms within units. The structure of the conveyor mechanism itself and its application in various production lines are well known to those skilled in the art, and this embodiment does not impose further limitations on it.

[0164] By combining the above settings, a complete dual-chamber pre-filled syringe production line can be provided, thereby realizing a series of steps such as unpacking the pharmaceutical container 60, preparing the lyophilized material, assembling the liquid and lyophilized material into the pharmaceutical container 60, and assembling the syringe, which effectively improves the production efficiency of the dual-chamber pre-filled syringe and also helps to improve its production quality.

[0165] In some embodiments, the dual-chamber pre-filled syringe production line can also be used to produce other products, such as filling and capping liquid medication into vials, which will utilize the aforementioned filling mechanism 42 or freeze-dried material filling mechanism 33, etc. For mechanisms that are not used, conveying mechanisms such as conveyor lines can pass vials along the production line through these mechanisms, and these unused mechanisms do not operate.

[0166] Accordingly, in order to better achieve the technical effects of the embodiments of this application, the embodiments of this application also provide a method for producing a dual-chamber pre-filled syringe. Please refer to [link to relevant documentation]. Figure 11 It includes the following steps:

[0167] S1. The pharmaceutical container 60 is fed through the first feeding and conveying assembly 100;

[0168] S2. The freeze-dried material is fed through the second feeding conveyor assembly 200;

[0169] S3. The freeze-dried material supplied by the second feeding and conveying component 200 is transferred to the pharmaceutical container 60 supplied by the first feeding and conveying component 100 by the pick-and-place component 300.

[0170] In some embodiments, the method for producing the dual-chamber prefilled syringe can be implemented based on the aforementioned dual-chamber prefilled syringe production line or a production line having the aforementioned freeze-dried material transfer mechanism 10.

[0171] It is understood that the step numbers in the embodiments of this application do not necessarily represent the order in which they are implemented. For example, steps S1 and S2 can be implemented simultaneously, and the examples in this embodiment do not constitute an undue limitation on them.

[0172] In step S2, the second feeding conveying assembly 200 has four feeding states. In the first feeding state, both the first feeding position 241 and the second feeding position 242 of the second feeding conveying assembly 200 have freeze-dried material. In the second feeding state, the first feeding position 241 does not have freeze-dried material, but the second feeding position 242 does. In the third feeding state, the first feeding position 241 has freeze-dried material, but the second feeding position 242 does not. In the fourth feeding state, neither the first feeding position 241 nor the second feeding position 242 has freeze-dried material.

[0173] In some embodiments, the pharmaceutical container 60 being fed is tested by a testing agency and the test results are obtained; in step S2, the feeding state of the second feeding conveying assembly 200 is switched according to the test results.

[0174] In some embodiments, step S3 specifically includes:

[0175] S31. At the first station, the freeze-dried material supplied by the second feeding and conveying component 200 is obtained by the pick-and-place component 300;

[0176] S33. Rotate the pick-and-place assembly 300 to the third station and place the freeze-dried material into the pharmaceutical container 60.

[0177] In some embodiments, the following steps are provided before step S33:

[0178] S32. Rotate the pick-and-place assembly 300 from the first station to the second station, and inspect the freeze-dried material through the second inspection mechanism 500.

[0179] In some embodiments, the following steps are provided before step S33:

[0180] S34. Rotate the pick-and-place assembly 300 from the third station to the fourth station, and spray air outward at the fourth station to clean the air passage of the pick-and-place assembly 300.

[0181] In some embodiments, prior to step S1, the following steps are performed: filling the pharmaceutical container 60 with liquid and forming a liquid chamber for containing the liquid.

[0182] In some embodiments, prior to step S1, the following step is performed: supplying a pharmaceutical container 60 through the pharmaceutical container supply unit 20. This pharmaceutical container 60 is typically a pharmaceutical container already filled with liquid. Specific implementation examples have been described in the foregoing embodiments and will not be repeated here.

[0183] In some embodiments, prior to step S2, the following step is performed: supplying freeze-dried material through the freeze-dried material supply unit 30. Specific implementation examples have been described in the foregoing embodiments and will not be repeated here.

[0184] In some embodiments, after step S3, the pharmaceutical container 60 pre-loaded with liquid components and lyophilized material is assembled into a syringe by the dispensing unit 50 and then dispensed. Specific implementation examples have been described in the foregoing embodiments and will not be repeated here.

[0185] Accordingly, in order to better achieve the technical effects of the embodiments of this application, please refer to Figure 12 This application also provides a control device 70 for a dual-chamber pre-filled syringe production line, which includes a detection mechanism 600, a controller 71, and the aforementioned freeze-dried material transfer mechanism 10. The detection mechanism 600 is used to detect the feeding pharmaceutical container 60 and obtain the detection result; the controller 71 is signal-connected to the freeze-dried material transfer mechanism 10 and the detection mechanism 600, and adjusts the feeding state of the second screw 240 of the freeze-dried material transfer mechanism 10 based on the detection result.

[0186] For example, when the test results show that two consecutive pharmaceutical containers 60 meet the standard, the controller controls the second feeding conveyor to be in the first feeding state; when the test results show that the previous pharmaceutical container 60 does not meet the standard but the next pharmaceutical container 60 does, the controller controls the second feeding conveyor to be in the aforementioned second feeding state; when the test results show that the previous pharmaceutical container 60 meets the standard but the next pharmaceutical container 60 does not, the controller controls the second feeding conveyor to be in the aforementioned third feeding state; when the test results show that two consecutive pharmaceutical containers 60 do not meet the standard, the controller controls the second feeding conveyor to be in the fourth feeding state.

[0187] In some embodiments, the controller controls the aforementioned dual-chamber pre-filled syringe production line to produce dual-chamber pre-filled syringes according to the aforementioned dual-chamber pre-filled syringe production method.

[0188] In some embodiments, the control device for the dual-chamber pre-filled syringe production line further includes a memory 72 for storing computer programs. The processor 71 and the memory 72 are connected by signals. When the computer program is executed by the processor 71, it is used to implement the aforementioned dual-chamber pre-filled syringe production method.

[0189] Accordingly, in order to better achieve the technical effects of the embodiments of this application, the embodiments of this application also provide a non-volatile computer-readable storage medium, on which a computer program is stored, and the computer program is executed by a processor to implement the steps in the aforementioned method for producing a dual-chamber pre-filled syringe.

[0190] The specific limitations and implementation methods of the above steps can be found in the embodiments of the production method of the dual-lumen pre-filled syringe, and will not be repeated here. Those skilled in the art will understand that all or part of the processes in the above embodiments can be implemented by a computer program instructing related hardware. The related computer program can be stored in a non-volatile computer-readable storage medium. When executed, the computer program can include the processes of the embodiments of the above methods. Any references to memory, storage, databases, or other media used in the embodiments provided in this application can include non-volatile and / or volatile memory. Non-volatile memory may include read-only memory (ROM), programmable ROM (PROM), electrically programmable ROM (EPROM), electrically erasable programmable ROM (EEPROM), or flash memory. Volatile memory may include random access memory (RAM) or external cache memory. By way of illustration and not limitation, RAM is available in a variety of forms, such as static RAM (SRAM), dynamic RAM (DRAM), synchronous DRAM (SDRAM), dual data rate SDRAM (DDRSDRAM), enhanced SDRAM (ESDRAM), synchronous link DRAM (SLDRAM), RAMbus direct RAM (RDRAM), direct memory bus dynamic RAM (DRDRAM), and memory bus dynamic RAM (RDRAM).

[0191] Application Examples

[0192] This document provides an example of a dual-chamber pre-filled syringe production line in practical use, which is understood not to unduly limit this application.

[0193] Here, the entire dual-chamber pre-filled syringe production line is used under Class A laminar flow annular conditions to ensure sterility.

[0194] First, the freeze-drying molds are loaded onto the freeze-drying mold loading mechanism 31, which may include a loading turntable, etc. The loading turntable rotates and works in conjunction with the guardrails on the loading turntable to arrange the freeze-drying molds into a single row. Then, the freeze-drying molds are transferred to the front weighing mechanism 32 to complete the front weighing.

[0195] The freeze-drying mold is then transferred to the freeze-drying material filling mechanism 33, where the liquid medicine is filled into the mold. The mold containing the liquid medicine is then sent to the subsequent weighing mechanism 34. The difference between the weight measured by the subsequent weighing mechanism 34 and the weight measured by the preceding weighing mechanism 32 is the weight of the filled liquid medicine. Freeze-drying molds that do not meet the required filling volume are discarded at subsequent stations. Freeze-drying molds that meet the requirements are conveyed to the entrance of the freeze-drying mechanism 36 via a transfer conveyor belt. The freeze-drying feeding mechanism 35 feeds the freeze-drying molds into the freeze-drying mechanism 36. After the entire batch of liquid medicine has been delivered to the freeze-drying mechanism 36, the door of the freeze-drying mechanism 36 is closed, and freeze-drying begins.

[0196] On the other hand, the packaged pharmaceutical container 60 is fed into the unpacking mechanism 21 for unpacking and retrieval of the nest box. A conveyor belt transports the nest box to the sealing paper heating mechanism 22, which ensures the sealing paper and heating elements are in full contact and heated, facilitating the removal of the sealing paper by the paper-retrieving mechanism 23. After heating, the conveyor belt transfers the nest box to the paper-retrieving mechanism 23, which descends and removes the sealing paper using a vacuum nozzle. The paper-retrieving mechanism 23 then rotates to the waste paper collection point, breaks the vacuum, and places the sealing paper into the waste paper collection device. After removing the sealing paper, the paper-retrieving mechanism 23 rotates back to the nest box, descends, and uses a vacuum nozzle to hold the inner liner paper. After rising and falling, it rotates to the waste paper collection point and places the inner liner paper into the waste paper collection device. Subsequently, the conveyor belt transports the nest box to downstream equipment.

[0197] The conveyor belt transports the nest box to the nest board removal mechanism 24. The mechanism 24 descends and removes the nest board from the nest box using a vacuum nozzle. After rotating, the mechanism descends again, placing the nest board in the nest board transfer conveyor line. The transfer conveyor line transports the nest board to the nest removal position, where the medicine container removal mechanism 25 descends and uses a vacuum to hold the medicine container 60. Then, the medicine container removal mechanism 25 rises, removing the medicine container 60 from the nest box and simultaneously widening the spacing between the medicine containers 60. This mechanism rotates 180° and descends again, placing the medicine container 60 into the double-layer medicine container transfer conveyor belt. The medicine container removal mechanism 25 then breaks the vacuum and rises again, and the medicine container transfer conveyor belt transports the medicine container 60 to downstream equipment.

[0198] After all the medicine containers 60 have been removed, the empty nesting boards are transferred to the nesting box retrieval mechanism via the nesting board transfer conveyor. The retrieval box mechanism descends, removes the empty nesting boards, and places them in the empty nesting box. The empty nesting box and empty nesting boards are then pushed into the empty nesting box collection belt by the push-out mechanism in the conveyor belt.

[0199] The pharmaceutical container feed conveyor belt transfers the pharmaceutical container 60, after it has been decoupled from the upstream feeder, onto the main conveyor belt. The main conveyor belt then transfers the pharmaceutical container 60 to the first sealing mechanism 41, where an intermediate rubber stopper is added. The first sealing mechanism 41 then adds the rubber stopper into the pharmaceutical container 60.

[0200] After the intermediate rubber stopper is added, the pharmaceutical container 60 is transferred by the main conveyor belt to the weighing station of the second testing institution 500 for weighing.

[0201] Subsequently, the main conveyor belt transports the pharmaceutical container 60 to the filling mechanism 42, where the filling mechanism 42 fills the diluent into the pharmaceutical container 60. The main conveyor belt then transports the pharmaceutical container 60 to the post-weighing position of the second testing mechanism 500 for post-weighing.

[0202] Then, the main conveyor belt transports the pharmaceutical container 60 to the second sealing mechanism 43 for sealing with rubber stoppers. After sealing, the pharmaceutical container 60 is transferred to the waste rejection star wheel. The waste rejection star wheel uses vacuum to pick up products without rubber stoppers and those that do not meet the weight requirements and transfers them to the waste rejection channel. Normal pharmaceutical containers 60 are transferred to downstream equipment through the discharge star wheel.

[0203] The pharmaceutical container 60, after being filled with diluent, is transferred to the freeze-dried material transfer mechanism 10 via a first feeding conveyor assembly 100, such as a feeding star wheel or a mesh belt. A first flipping mechanism 45 removes the pharmaceutical container 60 from the mesh belt, flips it 180°, and puts it back on the mesh belt. The mesh belt transfers the pharmaceutical container 60 to the weighing position in front of the testing mechanism 600 for weighing. A second feeding conveyor assembly 200, including a transfer mesh belt, transfers the freeze-dried product to the freeze-dried material transfer mechanism 10. The freeze-dried material transfer mechanism 10 at station 4 descends and removes the freeze-dried material from the freeze-drying mold using vacuum. Then, the freeze-dried material transfer mechanism 10 rotates, transferring the freeze-dried material to a third station and placing the freeze-dried material into the pharmaceutical container 60.

[0204] Subsequently, the conveyor belt transports the pharmaceutical container 60 to the weighing position of the testing mechanism 600 for weighing. After weighing, the conveyor belt transports the pharmaceutical container 60 to the third sealing mechanism 47 to complete the addition of the front rubber stopper. Then, the conveyor belt transports the finished product to the rejection star wheel, which uses vacuum suction to transport pharmaceutical containers 60 without powder cake, with unqualified powder cake weight, or without a front rubber stopper to the rejection channel. Qualified products are transported to the discharge unit 50 via the discharge star wheel for component assembly.

[0205] In the discharge unit 50, the pharmaceutical container 60 completes the installation of the adapter, top cap, back push, etc., and is then discharged by the discharge mechanism 55.

[0206] It is understood that, unless otherwise specified, the terms used in the various embodiments of this application have the same meaning. For any content not described in detail in a particular embodiment, the specific implementation details can be found in the descriptions of other embodiments. The examples and technical effects shown in the foregoing embodiments can be implemented accordingly. For repeated parts, this embodiment will not elaborate further.

[0207] The freeze-dried material transfer mechanism, dual-chamber pre-filled syringe production line, production method, control device, and storage medium provided in this application have been described in detail above. Specific examples have been used to illustrate the principles and implementation methods of this application. The descriptions of the above embodiments are only for the purpose of helping to understand the method and core ideas of this application. At the same time, for those skilled in the art, there will be changes in the specific implementation methods and application scope based on the ideas of this application. Therefore, the content of this specification should not be construed as a limitation of this application.

Claims

1. A freeze-dried material transfer mechanism, characterized in that, include, The first feeding and conveying assembly is used to feed pharmaceutical containers; The second feeding and conveying assembly is used to feed freeze-dried materials. The second feeding and conveying assembly includes a first driving mechanism, a second driving mechanism, and a first screw and a second screw arranged coaxially. The first driving mechanism is driven to the first screw, and the second driving mechanism is driven to the second screw. The first screw and the second screw are arranged adjacent to each other along the conveying direction of the second feeding and conveying assembly. as well as The pick-and-place assembly is used to transfer the freeze-dried material supplied by the second feeding and conveying assembly into a pharmaceutical container supplied by the first feeding and conveying assembly; The second screw is provided with a first feeding position and a second feeding position. The first feeding position is located downstream of the second feeding position. Furthermore, the feeding state of the first feeding position and the second feeding position can be adjusted by switching the rotation frequency of the second screw. The second screw can switch between four feeding states, wherein, In the first feeding state, both the first feeding position and the second feeding position contain freeze-dried material; In the second feeding state, the first feeding position does not have freeze-dried material, while the second feeding position has freeze-dried material. In the third feeding state, the first feeding position has freeze-dried material, while the second feeding position does not have freeze-dried material. In the fourth feeding state, neither the first feeding position nor the second feeding position contains freeze-dried material; The pick-and-place assembly includes a drive component and at least one set of pick-and-place units. The drive component is used to drive the pick-and-place units to move between the first feeding conveying assembly and the second feeding conveying assembly to feed the freeze-dried material into the pharmaceutical container. The driving component can drive the pick-and-place unit to switch between the first station and the third station; At the first workstation, at least one set of the pick-and-place units corresponds to the first and second feeding positions of the second screw to obtain freeze-dried material; At the third station, at least one set of the pick-and-place units corresponds to the position of the first feeding and conveying assembly to place the freeze-dried material into a pharmaceutical container; Each set of pick-and-place units includes two pick-and-place components, and the arrangement of the two pick-and-place components corresponds to the arrangement of the first feeding position and the second feeding position.

2. The freeze-dried material transfer mechanism according to claim 1, characterized in that, It also includes, Testing agencies are used to test pharmaceutical containers used for feeding materials and obtain test results; The second feeding and conveying assembly adjusts the feeding state of the second screw based on the detection results.

3. The freeze-dried material transfer mechanism according to claim 1, characterized in that, The driving component can also drive the pick-and-place unit to the second station, where a second detection mechanism is provided for detecting the freeze-dried material.

4. The freeze-dried material transfer mechanism according to claim 1, characterized in that, The drive unit can also drive the pick-and-place unit to the fourth station, which is a cleaning station.

5. The freeze-dried material transfer mechanism according to claim 1, characterized in that, The driving component includes a rotary driving component, which is connected to the pick-and-place unit to drive the pick-and-place unit to rotate and switch between the first station, the second station, the third station and the fourth station. The first, second, third, and fourth workstations are arranged evenly along the circumference.

6. The freeze-dried material transfer mechanism according to claim 4, characterized in that, The pick-and-place device is a vacuum adsorption device, and a collection container is provided at the fourth station to collect the ejected material when the pick-and-place device sprays air outward.

7. The freeze-dried material transfer mechanism according to claim 6, characterized in that, The pick-and-place assembly is also provided with a central shaft, a vacuum source and a support. The central shaft is connected to the support via a slip ring. The vacuum source gas is connected to the slip ring, and the slip ring gas is connected to each of the vacuum adsorption elements to provide positive or negative pressure to each of the vacuum adsorption elements.

8. The freeze-dried material transfer mechanism according to claim 5, characterized in that, The pick-and-place assembly includes four sets of pick-and-place units, which are evenly arranged along the circumference.

9. The freeze-dried material transfer mechanism according to claim 5, characterized in that, The driving component further includes a lifting driving component, which is connected to the pick-and-place unit and is used to drive the pick-and-place unit to move up and down.

10. The freeze-dried material transfer mechanism according to claim 9, characterized in that, It also includes a connector, the rotary drive is disposed on the connector, the pick-and-place assembly has a central shaft, the pick-and-place unit is connected to the central shaft, the central shaft is rotatably connected to the connector and is driven by the rotary drive, and the lifting drive is connected to the connector to drive the connector, the rotary drive and the pick-and-place unit to lift.

11. A dual-chamber pre-filled syringe production line, characterized in that, Includes a filling unit, the filling unit comprising, A first sealing mechanism is used to provide a first sealing body in a pharmaceutical container; A filling mechanism is located downstream of the first sealing mechanism, and the filling mechanism is used to fill liquid into a pharmaceutical container; A second sealing mechanism is disposed downstream of the filling mechanism. The second sealing mechanism is used to provide a second sealing body in the pharmaceutical container, and a liquid chamber for containing the liquid is formed between the first sealing body and the second sealing body. The freeze-dried material transfer mechanism according to any one of claims 1 to 10 is disposed downstream of the second sealing mechanism for adding freeze-dried material into a pharmaceutical container; A third sealing mechanism is disposed downstream of the freeze-dried material transfer mechanism for providing a third sealing body in the pharmaceutical container for sealing the freeze-dried material.

12. The dual-chamber pre-filled syringe production line according to claim 11, characterized in that, Downstream of the second sealing mechanism and upstream of the freeze-dried material transfer mechanism, a first flipping mechanism is provided, which is used to flip the pharmaceutical container. A chamber for accommodating the freeze-dried material is formed between the first sealing body and the third sealing body.

13. The dual-chamber pre-filled syringe production line according to claim 11, characterized in that, It also includes a laminar flow hood, in which the first sealing mechanism, the filling mechanism, the second sealing mechanism, and the freeze-dried material removal mechanism are disposed and are in a Class A laminar flow environment.

14. The dual-chamber pre-filled syringe production line according to claim 11, characterized in that, It also includes, A pharmaceutical container supply unit is disposed upstream of the filling unit for supplying pharmaceutical containers to the filling unit; A freeze-dried material supply unit is disposed upstream of the filling unit for supplying freeze-dried material to the filling unit; as well as The dispensing unit, located downstream of the filling unit, is used to dispense the pharmaceutical container pre-filled with liquid components and lyophilized material after it has been assembled into a syringe.

15. A method for producing a dual-chamber pre-filled syringe, characterized in that, Includes the following steps, The pharmaceutical containers are fed through the first feeding and conveying assembly; The freeze-dried material is fed through the second feeding and conveying assembly; The freeze-dried material supplied by the second feeding and conveying component is transferred to the pharmaceutical container supplied by the first feeding and conveying component by the pick-and-place component; The second feeding and conveying assembly has four feeding states. In the first feeding state, both the first and second feeding positions of the second feeding and conveying assembly have freeze-dried material. In the second feeding state, the first feeding position does not have freeze-dried material, but the second feeding position does. In the third feeding state, the first feeding position has freeze-dried material, but the second feeding position does not. In the fourth feeding state, neither the first nor the second feeding position has freeze-dried material. The pharmaceutical containers used for feeding are tested by a testing agency, and the test results are obtained. The feeding state of the second feeding and conveying component is switched according to the detection results.

16. The method for producing a dual-chamber pre-filled syringe according to claim 15, characterized in that, The step of transferring the freeze-dried material supplied by the second feeding and conveying component to the pharmaceutical container supplied by the first feeding and conveying component via the pick-and-place component specifically includes, At the first station, the freeze-dried material supplied by the second feeding and conveying component is obtained through the pick-and-place component; Rotate the pick-and-place assembly to the third station and place the freeze-dried material into a pharmaceutical container.

17. The method for producing a dual-chamber pre-filled syringe according to claim 16, characterized in that, Before the step of rotating the pick-and-place assembly to the third station and placing the freeze-dried material into the pharmaceutical container, the pick-and-place assembly is rotated to the second station, and the freeze-dried material is tested by the second testing mechanism.

18. The method for producing a dual-chamber pre-filled syringe according to claim 16, characterized in that, The pick-and-place assembly removes the lyophilized material by vacuum adsorption. After rotating the pick-and-place assembly to the third station and placing the lyophilized material in the pharmaceutical container, the pick-and-place assembly is rotated to the fourth station, and air is sprayed outward at the fourth station to clean the air path of the pick-and-place assembly.

19. The method for producing a dual-chamber pre-filled syringe according to claim 15, characterized in that, Before the step of feeding the pharmaceutical container through the first feeding conveyor assembly, the pharmaceutical container is filled with liquid to form a liquid chamber for containing the liquid.

20. The method for producing a dual-chamber pre-filled syringe according to claim 15, characterized in that, Before the step of feeding the pharmaceutical container through the first feeding and conveying assembly, the pharmaceutical container is supplied through the pharmaceutical container supply unit; Before the step of feeding the freeze-dried material through the second feeding and conveying assembly, the freeze-dried material is supplied by the freeze-dried material supply unit. After the step of transferring the freeze-dried material supplied by the second feeding conveyor assembly to the pharmaceutical container supplied by the first feeding conveyor assembly via the pick-and-place assembly, the pharmaceutical container pre-filled with liquid components and freeze-dried material is assembled into a syringe by the discharge unit and then discharged.

21. A control device for a dual-chamber pre-filled syringe production line, characterized in that, include, The freeze-dried material transfer mechanism according to any one of claims 1 to 10; Testing agencies are used to test pharmaceutical containers used for feeding materials and obtain test results; The controller is connected to the freeze-dried material transfer mechanism and the detection mechanism, and adjusts the feeding state of the second screw of the freeze-dried material transfer mechanism according to the detection results.

22. A non-volatile computer-readable storage medium, characterized in that, The non-volatile computer-readable storage medium stores a computer program that is executed by a processor to implement the steps of the method for producing a dual-chamber pre-filled syringe according to any one of claims 15 to 20.

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