A colloidal gold immunochromatography detection device

Abstract

The present invention relates to the technical field of colloidal gold immunochromatography analyzers, and discloses a colloidal gold immunochromatography detection device, including: an analyzer body, a detection area is arranged on the front side of the analyzer body, a protective door is rotatably arranged at the bottom of the detection area, a plurality of card insertion ports are arranged in the detection area, a test card body is inserted in the card insertion port, and a reserved installation port is opened on the plurality of card insertion ports, and a detachable and replaceable film component is arranged in the reserved installation port, which is used to film around the sample addition hole of the test card body and cover the splashed sample liquid around the sample addition hole. As the test card body continues to go deeper, the protective film gradually covers all around the sample addition hole of the test card body, ensuring that the splashed sample liquid around the sample addition hole of the test card body will not directly contact the upper wall of the card insertion port, preventing the residual sample liquid from affecting the contact between the test card body and the instrument, resulting in inaccurate test results and cross contamination of the detection instrument.

Description

Technical Field

[0001] The invention relates to the field of colloidal gold immunochromatography analyzers, and more specifically, to a colloidal gold immunochromatography detection device. Background Art

[0002] The colloidal gold immunochromatographic detection device is an instrument used to quickly, easily and accurately detect various antigens, antibodies, haptens and other biological molecules. The detection principle of the colloidal gold immunochromatographic analyzer is based on the specificity of the antigen-antibody reaction. When the antigen in the sample to be tested combines with the colloidal gold-labeled antibody, an antigen-antibody complex is formed. This complex moves on the chromatography paper. When it encounters a specific test line, due to the specific binding of the antigen and antibody, the complex will be fixed on the test line, thereby producing a color reaction.

[0003] Colloidal gold immunochromatographic analyzers usually require diluted blood to be dripped onto a test card for testing. When performing colloidal gold immunochromatographic analysis, the sample (such as blood) is generally mixed with a specific reagent first, and then the mixture is dripped into the sample well of the test card. Subsequently, the sample moves on the test card through capillary action and combines with the specific antigen fixed on the test card to form a visible test line. The instrument will scan and read the test line in the test card, and the color change or intensity of the test line will be recorded by the instrument. Based on the read data, the instrument will process and analyze the data to determine whether the sample contains the target substance and calculate the corresponding test results, thereby performing immunoassay;

[0004] However, when the sample liquid is dripped into the sample well of the test card body, bubbles may appear. After the bubbles burst, some sample liquid may splash around the sample well of the test card body, and the staff cannot see the tiny residues clearly with the naked eye. If there are residues around the sample wells of the test card, it may affect the accurate reading and analysis of the test card results by the colloidal gold immunochromatography analyzer. The residues may affect the contact between the test card and the instrument, resulting in inaccurate test results and cross-contamination of the detection instrument. For this reason, we propose a colloidal gold immunochromatography detection device. Summary of the invention

[0005] The present invention provides a colloidal gold immunochromatography detection device, which solves the technical problem in the related art that residues around the sample addition holes of a test card may affect the accurate reading and analysis results of the test card by a colloidal gold immunochromatography analyzer, and the residues may affect the contact between the test card and the instrument, resulting in inaccurate test results and cross contamination of the detection instrument.

[0006] The present invention provides a colloidal gold immunochromatography detection device, comprising: an analyzer body, a detection area is arranged at the front side of the analyzer body, a protective door is rotatably arranged at the bottom of the detection area, a plurality of card insertion ports are arranged in the detection area, a test card body is inserted in the card insertion ports, a reserved installation port is opened on the plurality of card insertion ports, a detachable and replaceable film covering component is arranged in the reserved installation port, and is used for covering the periphery of the sample adding hole of the test card body with a film, and covering the splashed sample liquid around the sample adding hole;

[0007] The film coating assembly includes a film rolling wheel, on which a protective film with equidistant dividing lines is rolled up, and a circle of adhesive layer is formed around the fitting surface of each section of the protective film, a support arm is provided on the side of the film rolling wheel close to the sample adding hole of the test card body, a film coating arm is rotatably provided on the side of the support arm close to the sample adding hole of the test card body, a film pressing body is fixedly provided on one end of the film coating arm close to the sample adding hole of the test card body, and the protective film is fitted with the film coating arm and goes around the bottom of the film pressing body to coat the test card body;

[0008] A distance measuring component is arranged inside the entrance of the card insertion port, which is used to measure the distance of the test card body inserted into the card insertion port and control the film pressing body to press the protective film around the sample adding hole of the test card body.

[0009] Furthermore, the range measuring assembly includes two grinding wheels connected by a rotating shaft, the spacing between the two grinding wheels is smaller than the width of the test card body, and the two grinding wheels are rotatably connected to the upper wall of the card insertion port through the rotating shaft, and the two grinding wheels protrude downward from the upper wall of the card insertion port.

[0010] Furthermore, a take-up wheel 1 is fixedly provided at the center position of the two grinding wheels, on which a travel belt is wound, and a take-up wheel 2 is fixedly provided at the end of the travel belt away from the take-up wheel 1 and rotatably connected to the analyzer body, and the outer walls of the rotating columns at both ends of the take-up wheel 2 are provided with a plurality of equidistant positioning grooves.

[0011] Furthermore, a winding spring sheet is fixedly provided on the rotating columns at both ends of the winding wheel, an air storage bag is fixedly provided on the inner wall of the winding spring sheet, the output end of the air storage bag is connected to an air supply pipe, the output end of the air supply pipe is provided with an air outlet head, and the air outlet head is used to provide power for coating the coating assembly and pressurizing the sample adding hole.

[0012] Furthermore, the coating assembly also includes an assembly body that matches the reserved installation port and is used to replace the film rolling wheel. An assembly groove is provided inside the assembly body, and a limiting groove is provided on one side of the assembly groove close to the rotating columns at both ends of the film rolling wheel. The film rolling wheel is rotatably connected to the assembly body.

[0013] Furthermore, a clamping ring rotatably connected to the film rolling wheel is fixedly provided at one end of the support arm close to the rotating columns at both ends of the film rolling wheel, a blocking head slidably connected to the clamping ring is passed through the center position of the clamping ring, and an air duct is provided inside the support arm where the blocking head is away from the rotating columns at both ends of the film rolling wheel, and the air duct is a group of ventilation pipes.

[0014] Furthermore, an air inlet hole is provided at the air inlet end of the air duct, and the air inlet hole is opened on the lower wall of the support arm. The diameter of the air inlet hole gradually decreases from bottom to top, and the positions of the air inlet hole and the air outlet head are aligned with each other and the shapes match each other.

[0015] Furthermore, the film pressing body includes four piston columns fixedly connected to it and passing through the film covering arm. At the same time, the film pressing body forms a telescopic structure with the film covering arm through the piston column. The sliding space between the piston column and the film covering arm is connected to the output end of the air channel through a pipeline, which is used to inject air into this space to push the film pressing body downward.

[0016] Furthermore, a pressing plate is fixedly arranged between the two film-covering arms, a pressing balloon is fixedly arranged at the center of the pressing plate, and the thickness of the lower wall of the pressing balloon gradually decreases from the center to the outer circle, an air supply pipe is arranged at the air inlet end of the pressing balloon, and a plurality of pressure-bearing bag columns fixedly connected to the lower wall of the pressing body are arranged at one end of the air supply pipe away from the pressing balloon, and the plurality of pressure-bearing bag columns are connected to each other.

[0017] Furthermore, a plurality of pressure-bearing capsule columns are provided with integral film-absorbing columns inside, the bottom of the film-absorbing columns penetrates through the lower wall of the pressure-bearing capsule columns, and the inside of the film-absorbing columns is a hollow structure.

[0018] The beneficial effects of the present invention are:

[0019] When the test card body is inserted into the card insertion port, the two card grinding wheels of the range measuring component detect that the sample adding hole of the test card body is about to enter the card insertion port, so that the film pressing body automatically presses down to tightly press the protective film on the test card body. As the test card body continues to penetrate, the protective film gradually covers all the areas around the sample adding hole of the test card body, ensuring that splashed sample liquid around the sample adding hole of the test card body will not directly contact the upper wall of the card insertion port, preventing residual sample liquid from affecting the contact between the test card body and the instrument, resulting in inaccurate test results and cross contamination of the detection instrument.

[0020] After the sample pressing balloon is inflated, as the sample pressing balloon slides to the sample adding hole position of the test card body, the sample pressing balloon presses down the protective film at the sample adding hole position of the test card body, thereby increasing the pressure in the sample adding hole of the test card body, which is beneficial to increase the speed at which the sample liquid in the sample adding hole penetrates into the test strip paper and reduces the speed at which the sample liquid penetrates. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 It is a schematic diagram of the overall structure of the present invention;

[0022] Figure 2 It is a schematic diagram of the assembly structure of the present invention;

[0023] Figure 3 It is a schematic diagram of the protective film structure of the present invention;

[0024] Figure 4 It is a schematic diagram of the film rolling wheel structure of the present invention;

[0025] Figure 5 The present invention Figure 4 The enlarged schematic diagram at A in the middle;

[0026] Figure 6 It is a schematic diagram of the support arm structure of the present invention;

[0027] Figure 7 The present invention Figure 6 The enlarged schematic diagram of point B in the middle;

[0028] Figure 8 The present invention Figure 6 The enlarged schematic diagram at C in the middle;

[0029] Fig. 9 It is a schematic diagram of the structure of the film pressing body of the present invention;

[0030] Fig.10 The present invention Fig. 9 The enlarged schematic diagram at D in the middle;

[0031] Fig.11 It is a schematic diagram of the coiled spring structure of the present invention.

[0032] In the figure: 11, analyzer body; 12, detection area; 13, protective door; 14, reserved installation port; 15, card insertion port; 16, test card body; 2, film covering assembly; 21, assembly body; 22, assembly slot; 23, limit slot; 24, film rolling wheel; 25, clamping slot; 26, protective film; 27, support arm; 271, clamping ring; 272, film covering arm; 273, film pressing body; 274, film pressing column; 275, film limiting port; 276, sample pressing plate; 2 77. Blocking head; 278. Air inlet; 279. Air duct; 28. Limiting port; 281. Limiting buckle; 282. Reset belt; 201. Sample pressing balloon; 202. Air supply pipe; 203. Pressure bag column; 204. Piston column; 205. Film suction column; 3. Range measuring component; 31. Grinding wheel; 32. Take-up wheel 1; 33. Travel belt; 34. Take-up wheel 2; 36. Take-up spring; 37. Air supply pipe; 38. Air outlet; 39. Air storage bag. DETAILED DESCRIPTION

[0033] The subject matter described herein will now be discussed with reference to example embodiments. It should be understood that the discussion of these embodiments is only to enable those skilled in the art to better understand and implement the subject matter described herein, and the functions and arrangements of the elements discussed may be changed without departing from the scope of protection of the contents of this specification. Each example may omit, replace or add various processes or components as needed. In addition, the features described relative to some examples may also be combined in other examples.

[0034] like Figure 1 - Fig.11 As shown, a colloidal gold immunochromatographic detection device comprises: an analyzer body 11, a detection area 12 is arranged on the front side of the analyzer body 11, a protective door 13 is rotatably arranged at the bottom of the detection area 12, a plurality of card insertion ports 15 are arranged in the detection area 12, a test card body 16 is inserted in the card insertion port 15, a prepared sample is dripped into a designated sample addition hole of the test card body 16, and then the test card body 16 loaded with the sample is correctly inserted into the card insertion port 15 of the colloidal gold immunochromatographic analyzer, ensuring that the test card body 16 is tightly fitted with the card insertion port 15, without The test card body 16 will not be skewed or loosened, and then the protective door 13 of the detection area 12 will be closed to ensure that the test card body 16 will not be disturbed by the outside world during the detection process. Finally, the instrument will scan and read the detection line in the test card body 16, and the color change or intensity of the detection line will be recorded by the instrument. According to the read data, the instrument will process and analyze the data to determine whether the sample contains the target substance and calculate the corresponding test results. Finally, the analysis results will be displayed on the display screen of the instrument or printed out, and the user can view the test results intuitively.

[0035] A plurality of card insertion ports 15 are provided with reserved installation ports 14, in which a detachable and replaceable film covering component 2 is arranged, which is used to cover the surroundings of the sample adding holes of the test card body 16 and cover the splashed sample liquid around the sample adding holes;

[0036] The film coating assembly 2 includes a film rolling wheel 24, on which a protective film 26 with equidistant dividing lines is rolled up, and a circle of adhesive layer is formed around the fitting surface of each section of the protective film 26, and a support arm 27 is provided on the side of the film rolling wheel 24 close to the sample loading hole of the test card body 16, and a film coating arm 272 is rotatably provided on the side of the support arm 27 close to the sample loading hole of the test card body 16, and a film pressing body 273 is fixedly provided on one end of the film coating arm 272 close to the sample loading hole of the test card body 16, and the protective film 26 is fitted with the film coating arm 272 and goes around the bottom of the film pressing body 273 to coat the test card body 16;

[0037] When the test card body 16 is inserted into the card insertion port 15, the rotation stroke of the two card grinding wheels 31 of the range measuring component 3 detects that the sample adding hole of the test card body 16 is about to enter the card insertion port 15, so that the film pressing body 273 automatically presses down to press the protective film 26 tightly on the test card body 16. When the staff drips the sample liquid into the sample adding hole of the test card body 16, bubbles may appear. After the bubbles burst, some sample liquid may splash around the sample adding hole of the test card body 16, and the staff cannot see the tiny residue clearly with the naked eye. As the test card body 16 continues to go deeper, the protective film 26 gradually covers all around the sample adding hole of the test card body 16, ensuring that the splashed sample liquid around the sample adding hole of the test card body 16 will not directly contact the upper wall of the card insertion port 15, preventing the residual sample liquid from affecting the contact between the test card body 16 and the instrument, resulting in inaccurate test results and cross contamination of the detection instrument.

[0038] A distance measuring component 3 is disposed inside the entrance of the card insertion port 15 for measuring the distance of the test card body 16 inserted into the card insertion port 15 and controlling the film pressing body 273 to press the protective film 26 around the sample adding hole of the test card body 16 .

[0039] The range measuring component 3 includes two grinding wheels 31 connected by a rotating shaft, the spacing between the two grinding wheels 31 is smaller than the width of the test card body 16, and the two grinding wheels 31 are rotatably connected to the upper wall of the card insertion port 15 through the rotating shaft, and the two grinding wheels 31 protrude downward from the upper wall of the card insertion port 15. When the test card body 16 is inserted into the card insertion port 15, the two grinding wheels 31 are in contact with the upper wall of the test card body 16 at the same time, and the grinding wheels 31 are driven to rotate as the test card body 16 goes deeper. The rotation stroke of the grinding wheels 31 represents the distance the test card body 16 is inserted into the card insertion port 15, which is used to accurately judge when the sample adding hole of the test card body 16 enters the card insertion port 15 and when the sample adding hole of the test card body 16 is coated.

[0040] A take-up wheel 1 32 is fixedly provided at the center position of the two grinding wheels 31, and a travel belt 33 is rolled up on the take-up wheel 1 32. A take-up wheel 2 34 rotatably connected to the analyzer body 11 is fixedly provided at one end of the travel belt 33 away from the take-up wheel 1 32. A plurality of equidistant positioning grooves 25 are provided on the outer walls of the rotating columns at both ends of the take-up wheel 2 34. As the test card body 16 goes deeper, the two grinding wheels 31 and the rotating columns are driven to rotate at the same speed, so that the take-up wheel 1 32 is driven to roll up the travel belt 33 on the take-up wheel 2 34. At the same time, the travel belt 33 is released by the tension, driving the take-up wheel 2 34 to rotate. The length of the travel belt 33 rolled up by the take-up wheel 1 32 matches the depth of the test card body 16 entering the card insertion port 15.

[0041] A coil spring 36 is fixedly provided on the rotating columns at both ends of the winding wheel 34, and an air storage bag 39 is fixedly provided on the inner wall of the coil spring 36. The output end of the air storage bag 39 is connected to the air supply pipe 37, and the output end of the air supply pipe 37 is provided with an air outlet head 38, and the air outlet head 38 is used to provide power for the film coating component 2 to coat the film and pressurize the sample adding hole. When the winding wheel 34 releases the travel belt 33, it drives the coil spring 36 to rewind, and the air storage bag 39 is squeezed by the winding of the coil spring 36. The tighter the coil spring 36 is rolled, the more severe the squeezing of the air storage bag 39 is, and the air in the air storage bag 39 flows into the air inlet hole 278 through the air supply pipe 37 and the air outlet head 38;

[0042] A limiting opening 28 is provided at the connecting end of the support arm 27 and the coating arm 272, and a limiting buckle 281 which is fixedly connected to the coating arm 272 is rotatably provided inside the limiting opening 28, and a reset belt 282 is provided on the top of the limiting buckle 281. The coating arm 272 is rotatably connected to the support arm 27. On the one hand, when installing the coating assembly 2, it is convenient to insert the coating arm 272 into the assembly groove 22, and when installing the assembled coating assembly 2 in the reserved installation opening 14, the coating arm 272 can be rotated clockwise, which is conducive to installation. After the installation is completed, the coating arm 272 is reset and tightly attached to the upper wall of the card insertion port 15 through the pulling force of the reset belt 282.

[0043] The film coating component 2 also includes an assembly body 21 that matches the reserved installation port 14 and is used to replace the film winding wheel 24. An assembly groove 22 is provided inside the assembly body 21. A limiting groove 23 is provided on one side of the assembly groove 22 close to the rotating columns at both ends of the film winding wheel 24. The film winding wheel 24 is rotatably connected to the assembly body 21. When installing the film coating component 2, first press the new film winding wheel 24 on the bottom of the assembly groove 22 to make the rotating column of the film winding wheel 24 rotate at the bottom of the limiting groove 23. Then, pull out the protective film 26 and pass through the coating arm 272 and the film pressing column 274 on the coating arm 272, and pass through the film limiting port 275 in the film pressing column 274 to the lower wall of the film pressing body 273, which is conducive to ensuring the stable output of the protective film 26 when it is pulled out.

[0044] A retaining ring 271 rotatably connected to the film rolling wheel 24 is fixedly provided at one end of the support arm 27 close to the rotating columns at both ends of the film rolling wheel 24, and a blocking head 277 slidably connected to the retaining ring 271 is passed through the center position of the retaining ring 271. An air duct 279 is provided inside the support arm 27 away from the rotating columns at both ends of the film rolling wheel 24, and the air duct 279 is a group of ventilation pipes.

[0045] The air inlet end of the air passage 279 is provided with an air inlet hole 278, and the air inlet hole 278 is opened on the lower wall of the support arm 27, the diameter of the air inlet hole 278 gradually decreases from bottom to top, and the positions of the air inlet hole 278 and the air outlet head 38 are aligned with each other and the shapes match each other. When the film-coating assembly 2 is completely installed in the reserved installation opening 14, the air outlet head 38 is just inserted into the air inlet hole 278. When the film pressing body 273 completes the film coating around the sample adding hole of the test card body 16, as the test card body 16 continues to The deeper the test card body 16 goes, the deeper it goes, the more the rolling wheel 24 stops releasing the protective film 26, and the protective film 26 is subjected to increased tension, causing the protective film 26 to break at the dotted line.

[0046] The film pressing body 273 includes four piston rods 204 fixedly connected thereto and passing through the film coating arm 272. At the same time, the film pressing body 273 and the film coating arm 272 form a telescopic structure through the piston rod 204. The sliding space between the piston rod 204 and the film coating arm 272 is connected to the output end of the air channel 279 through a pipeline, which is used to inject air into this space to push the film pressing body 273 downward. The amount of air in the air bag 39 injected into the air channel 279 is during this period before the blocking head 277 extends. This interval allows the time for coating the surroundings of the sample addition holes of the test card body 16. The air first enters the sliding space of the film coating arm 272 to push the piston rod 204 downward, so that the film pressing body 273 is tightly pressed against the upper wall of the test card body 16. As the test card body 16 goes deeper, the surroundings of the sample addition holes of the test card body 16 are completely coated.

[0047] A sample pressing plate 276 is fixedly arranged between the two film covering arms 272, a sample pressing balloon 201 is fixedly arranged at the center of the sample pressing plate 276, and the thickness of the lower wall of the sample pressing balloon 201 gradually decreases from the center to the outer circle, an air supply pipe 202 is arranged at the air inlet end of the sample pressing balloon 201, and a plurality of pressure-bearing balloon columns 203 fixedly connected to the lower wall of the film pressing body 273 are arranged at one end of the air supply pipe 202 away from the sample pressing balloon 201, and the plurality of pressure-bearing balloon columns 203 are connected to each other;

[0048] The film pressing body 273 is tightly pressed against the test card body 16 and squeezes several pressure-bearing capsule columns 203 at the same time, so that the air in the pressure-bearing capsule columns 203 enters into the sample pressing balloon 201. After the sample pressing balloon 201 expands, as the sample pressing balloon 201 slides to the sample adding hole position of the test card body 16, the sample pressing balloon 201 presses down the protective film 26 at the sample adding hole position of the test card body 16, thereby increasing the pressure in the sample adding hole of the test card body 16, which is beneficial to increase the speed at which the sample liquid in the sample adding hole penetrates into the test strip paper and reduces the speed at which the sample liquid penetrates.

[0049] Several pressure-bearing capsule columns 203 are internally provided with integrated film-absorbing columns 205, the bottom of which passes through the lower wall of the pressure-bearing capsule column 203, and the interior of the film-absorbing column 205 is a hollow structure. After the film pressing is completed, the film pressing body 273 rises and the pressure-bearing capsule column 203 expands. The expansion of the pressure-bearing capsule column 203 expands the space of the film-absorbing column 205, so that the space of the film-absorbing column 205 is in a negative pressure state, which can suck the broken protective film 26 tightly to prevent it from sagging, which is conducive to inserting the test card body 16 for use next time.

[0050] The above describes an embodiment of the present embodiment, but the present embodiment is not limited to the above-mentioned specific implementation methods. The above-mentioned specific implementation methods are merely illustrative and not restrictive. Under the guidance of the present embodiment, ordinary technicians in this field can also make many forms, all of which are within the protection of the present embodiment.

Claims

1. A colloidal gold immunochromatography detection device, comprising: An analyzer body (11), wherein a detection area (12) is arranged at the front side of the analyzer body (11), a protective door (13) is rotatably arranged at the bottom of the detection area (12), a plurality of card insertion ports (15) are arranged in the detection area (12), a test card body (16) is inserted into the card insertion ports (15), and the plurality of card insertion ports (15) are each provided with a reserved installation port (14), wherein a detachable and replaceable film covering component (2) is arranged in the reserved installation port (14) and is used for covering the periphery of the sample addition hole of the test card body (16) with a film, so as to cover splashed sample liquid around the sample addition hole; The film coating assembly (2) comprises a film rolling wheel (24), on which a protective film (26) with equidistant dividing lines is rolled up, and each section of the protective film (26) has a circle of adhesive layer around its bonding surface, a support arm (27) is provided on the side of the film rolling wheel (24) close to the sample loading hole of the test card body (16), a film coating arm (272) is rotatably provided on the side of the support arm (27) close to the sample loading hole of the test card body (16), a film pressing body (273) is fixedly provided on one end of the film coating arm (272) close to the sample loading hole of the test card body (16), and the protective film (26) is attached to the film coating arm (272) and goes around the bottom of the film pressing body (273) to coat the test card body (16); A distance measuring component (3) is provided inside the entrance of the card insertion port (15) for measuring the distance of the test card body (16) inserted into the card insertion port (15) and controlling the film pressing body (273) to press the protective film (26) around the sample addition hole of the test card body (16); The range measuring assembly (3) comprises two grinding wheels (31) connected by a rotating shaft, the distance between the two grinding wheels (31) is smaller than the width of the test card body (16), and the two grinding wheels (31) are rotatably connected to the upper wall of the card insertion port (15) via the rotating shaft, and the two grinding wheels (31) protrude downward from the upper wall of the card insertion port (15); A belt reel (32) is fixedly disposed at the center of the two grinding wheels (31), a travel belt (33) is wound on the belt reel (32), a belt reel (34) is fixedly disposed at one end of the travel belt (33) away from the belt reel (32) and is rotatably connected to the analyzer body (11), and a plurality of equidistant positioning grooves (25) are provided on the outer walls of the rotating columns at both ends of the belt reel (34); A coil spring sheet (36) is fixedly provided on the rotating columns at both ends of the second winding wheel (34), an air storage bag (39) is fixedly provided on the inner wall of the coil spring sheet (36), an output end of the air storage bag (39) is connected to an air supply pipe (37), an output end of the air supply pipe (37) is provided with an air outlet head (38), and the air outlet head (38) is used to provide power for coating the coating assembly (2) and pressurizing the sample addition hole.

2. A colloidal gold immunochromatography detection device according to claim 1, characterized in that: The film coating assembly (2) further comprises an assembly body (21) matched with the reserved installation opening (14) and used for replacing the film rolling wheel (24); an assembly groove (22) is provided inside the assembly body (21); a limiting groove (23) is provided on one side of the assembly groove (22) close to the rotating columns at both ends of the film rolling wheel (24); and the film rolling wheel (24) is rotatably connected to the assembly body (21).

3. A colloidal gold immunochromatography detection device according to claim 1, characterized in that: A clamping ring (271) rotatably connected to the film rolling wheel (24) is fixedly provided at one end of the support arm (27) close to the rotating columns at both ends of the film rolling wheel (24), and a blocking head (277) slidably connected to the clamping ring (271) is passed through the center of the clamping ring (271), and an air duct (279) is provided inside the support arm (27) away from the rotating columns at both ends of the film rolling wheel (24), and the air duct (279) is a group of air ducts.

4. A colloidal gold immunochromatography detection device according to claim 3, characterized in that: An air inlet hole (278) is provided at the air inlet end of the air duct (279), and the air inlet hole (278) is opened on the lower wall of the support arm (27), the diameter of the air inlet hole (278) gradually decreases from bottom to top, and the air inlet hole (278) and the air outlet head (38) are aligned in position and matched in shape.

5. A colloidal gold immunochromatography detection device according to claim 4, characterized in that: The film pressing body (273) comprises four piston columns (204) fixedly connected thereto and penetrating through the film covering arm (272); the film pressing body (273) and the film covering arm (272) form a telescopic structure through the piston columns (204); the sliding space between the piston columns (204) and the film covering arm (272) is connected to the output end of the air channel (279) through a pipeline, so as to inject air into the space to push the film pressing body (273) downward.

6. A colloidal gold immunochromatography detection device according to claim 5, characterized in that: A sample pressing plate (276) is fixedly arranged between the two film covering arms (272), a sample pressing balloon (201) is fixedly arranged at the center of the sample pressing plate (276), and the thickness of the lower wall of the sample pressing balloon (201) gradually decreases from the center of the circle to the outer circle, an air supply pipe (202) is arranged at the air inlet end of the sample pressing balloon (201), and a plurality of pressure-bearing balloon columns (203) fixedly connected to the lower wall of the film pressing body (273) are arranged at one end of the air supply pipe (202) away from the sample pressing balloon (201), and the plurality of pressure-bearing balloon columns (203) are interconnected.

7. A colloidal gold immunochromatography detection device according to claim 6, characterized in that: A plurality of the pressure-bearing capsule columns (203) are provided with integral film-absorbing columns (205) therein, the bottom of the film-absorbing column (205) penetrates the lower wall of the pressure-bearing capsule column (203), and the interior of the film-absorbing column (205) is a hollow structure.

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