Composition with red fading effect and application thereof

Abstract

The invention discloses a composition with a red fading effect and application thereof. The composition is prepared from the following components in percentage by mass: 90 to 99 percent of fat-soluble solvent and 1 to 10 percent of saururus chinensis extract, wherein the fat-soluble solvent is selected from at least one of glycol, caprylic / capric triglyceride, sunflower seed oil, macadamia nut oil, meadowfoam seed oil, silicone oil, squalane, ethylhexyl palmitate, diisostearyl malate, polyglycerol-2 triisostearate, camelina seed oil, octyldodecanol and coconut oil alcohol-caprylate / caprate. The composition prepared by mixing the saururus chinensis extract and the fat-soluble solvent has a very remarkable red fading effect.

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetics, and in particular to a composition with redness-removing effect and application thereof. Background Art

[0002] In recent years, skin problems caused by sensitive skin, such as burning, itching, erythema, and damaged skin barrier, have attracted increasing attention. These skin discomfort symptoms are generally induced by endogenous or exogenous factors, and the most prominent manifestations are redness and burning. The mechanism behind them is closely related to vascular hyperreactivity. Among them, the red blood streaks caused by facial capillary dilation not only seriously affect the patient's beauty, but also cause a great psychological burden on the patient. With the development of society and the continuous improvement of people's living standards, the quality and performance requirements of cosmetics are also getting higher and higher. People hope that a series of functional cosmetics that are harmless to human health and have beauty and health care effects will appear.

[0003] Using Chinese herbal extracts as additives for beauty and skin care cosmetics has the characteristics of stable and long-lasting efficacy, mild effect on the skin, low irritation, high safety, and significant efficacy. At present, the fat-soluble cosmetic raw materials with redness-removing effect on the market are mainly anti-inflammatory models. Such raw materials are not only added in large quantities, but also take a long time to take effect, and cannot quickly solve the problem of skin redness. Water-soluble and alcohol-soluble cosmetic raw materials are difficult to be compatible with essential oils, makeup removers, and makeup products.

[0004] Saururus chinensis is sweet and spicy, and cold in nature. According to the Tang Materia Medica, it can treat edema, beriberi, promote defecation and urination, eliminate phlegm and bad habits, remove accumulation, and eliminate carbuncle. It has the effects of diuresis and detumescence, clearing away heat and detoxification, and can be used to treat edema, dysuria, and painful urination. Saururus chinensis contains a variety of chemical components, mainly lignans, flavonoids, volatile oils, alkaloids, polysaccharides, polyphenols, and fat-soluble terpenes. Summary of the invention

[0005] In view of the deficiencies of the prior art, the purpose of the present invention is to develop a cosmetic raw material that is compatible with essential oils, makeup remover oils, and makeup products, and can quickly and effectively improve skin redness and have skin barrier repair effects. Specifically, the purpose of the present invention is to provide a composition with redness-removing effect and its application. The present invention uses a fat-soluble Saururus chinensis extract and dissolves it in a specific fat-soluble solvent to obtain a composition with significant redness-removing effect.

[0006] The objective of the present invention is achieved through the following technical solutions:

[0007] In a first aspect, the present invention provides a composition having the effect of removing redness, comprising the following components in percentage by weight: 90-99% of a fat-soluble solvent, 1-10% of a Saururus chinensis extract;

[0008] The fat-soluble solvent is selected from at least one of hexylene glycol, caprylic / capric triglyceride, sunflower seed oil, macadamia nut oil, meadowfoam seed oil, silicone oil, squalane, ethylhexyl palmitate, diisostearyl malate, polyglyceryl-2 triisostearate, camelina seed oil, octyldodecanol, and coconut oil caprylate / caprate.

[0009] As a preferred embodiment, the composition comprises the following components in percentage by weight: 90-97% fat-soluble solvent, 3-10% Saururus chinensis extract. More preferably, the composition comprises the following components in percentage by weight: 90-95% fat-soluble solvent, 3-5% Saururus chinensis extract.

[0010] As a preferred embodiment, the fat-soluble solvent is selected from at least one of hexyl glycol, caprylic / capric triglyceride, sunflower seed oil, macadamia oil, white meadowfoam seed oil, ethylhexyl palmitate, diisostearyl malate, polyglyceryl-2 triisostearate, camelina seed oil, and octyldodecanol. In the previous experimental studies of the inventors, it was found that the type of fat-soluble solvent used has a great influence on the solubility and stability of the prepared composition, thereby affecting the redness-removing effect. For example, when the fat-soluble solvent used is silicone oil, squalane, coconut oil alcohol-caprylate / caprate, the solubility and stability of the prepared composition are poor.

[0011] As a further preferred embodiment, the fat-soluble solvent is selected from at least one of caprylic / capric triglyceride, macadamia oil, and octyldodecanol, and the composition prepared therefrom has the best redness-removing effect.

[0012] As a preferred embodiment, the Saururus chinensis extract is a fat-soluble Saururus chinensis extract.

[0013] As a preferred embodiment, the Saururus chinensis extract is prepared by the following method:

[0014] The raw material of Saururus chinensis is extracted with alcohol, then filtered, adsorbed with resin, desorbed with alcohol, concentrated and dried to obtain the product.

[0015] As a preferred embodiment, the alcohol is selected from at least one of ethanol, propanol, butanol, glycerol and butanediol.

[0016] As a preferred embodiment, the resin is a macroporous resin.

[0017] As a preferred embodiment, after the alcohol elution, a decolorization step is also included.

[0018] As a preferred embodiment, the preparation method of the Saururus chinensis extract comprises the following steps:

[0019] A1. Extraction: Cut the raw material of Saururus chinensis into sections and perform reflux extraction with 60-70% ethanol by volume;

[0020] A2. Enrichment: The extract obtained in step A1 is filtered, and the obtained filtrate a is subjected to macroporous resin, and then desorbed with 80-95% ethanol by volume, and the desorbed liquid is collected, concentrated and dried to obtain the Saururus chinensis extract.

[0021] As a preferred embodiment, in step A1, the temperature of the reflux extraction is 80-90°C, the number of extractions is 2-3 times, and the time of each extraction is 1.0-2.0h.

[0022] As a preferred embodiment, in step A1, the amount of ethanol used is 6 to 12 Bv.

[0023] As a preferred embodiment, in step A2, the macroporous resin is selected from at least one of D101, D101C, LX-100B, LX-T28, LX-T81, AB-8, and DM130.

[0024] As a preferred embodiment, in step A2, the volume mass ratio of the macroporous resin to the Saururus chinensis raw material is 0.5-2 (ml):1 (g); and the flow rate of the filtrate a is 0.5-3 Bv / h.

[0025] As a preferred solution, in step A2, the amount of ethanol with a volume fraction of 80-95% is 1-6 times the volume of the macroporous resin, and the flow rate is 0.5-3 Bv / h.

[0026] As a further preferred embodiment, in step A2, the ethanol used for desorption is ethanol with a volume fraction of 90-95%, and most preferably ethanol with a volume fraction of 90%.

[0027] As a preferred embodiment, in step A2, the vacuum degree used for the concentrated drying is 0.01-0.1 MPa and the temperature is 50-70°C.

[0028] In the previous experimental research of the inventor, it was found that when the Saururus chinensis extract obtained by the aforementioned extraction and enrichment steps is used in the composition, the red-fading effect of the composition can be further improved. Among them, when the volume fraction of ethanol of 80-95% is specifically used in step A2, and the amount thereof is 1-6 times the volume of the macroporous resin for desorption, the red-fading effect of the obtained Saururus chinensis extract after being used in the composition can be better; if less than 80% ethanol is used for desorption, or the amount of 80% ethanol used is too low or too low, the red-fading effect of the corresponding composition obtained will decrease to varying degrees.

[0029] As a further preferred embodiment, in order to remove the pigment in the Saururus chinensis extract and lighten the color of the Saururus chinensis extract, so that the prepared composition can be actually applied to cosmetic products, in step A2, the collected desorption liquid further includes a decolorization step before being concentrated and dried;

[0030] The decolorization step is specifically as follows: the desorption liquid is first decolorized with activated carbon and then filtered, the obtained filtrate b is then decolorized with an anionic macroporous resin, the decolorized liquid is collected and the pH is adjusted to 6.5-7.1.

[0031] As a preferred solution, in the decolorization step, the activated carbon is coconut shell activated carbon with a mesh size of 200-300 meshes; the amount of the activated carbon used is 0.1-1% of the mass of the Saururus chinensis raw material. The use of activated carbon can remove impurities such as chlorophyll in the desorption liquid, thereby improving the stability of the Saururus chinensis extract and making the color lighter.

[0032] As a preferred embodiment, in the decolorization step, the temperature for decolorization with activated carbon is 15 to 60° C., and the stirring time is 20 to 60 minutes.

[0033] As a preferred embodiment, in the decolorization step, the filtration is performed using a 0.22-0.8 um membrane.

[0034] As a preferred embodiment, in the decolorization step, the anionic macroporous resin is a weak anionic macroporous resin, specifically selected from at least one of LX-T5, LX-94, D941, LXD-762, LXB-AS, and LXB-400. The anionic macroporous resin can remove the red pigment impurities in the filtrate b.

[0035] As a preferred embodiment, in the decolorization step, when the anionic macroporous resin is used for decolorization, the volume ratio of the filtrate b to the anionic macroporous resin is 10 to 30:1, and the flow rate of the filtrate b is 0.5 to 3 Bv / h. When the dosage of the anionic macroporous resin is too high, the red-fading effect of the final prepared composition will decrease; and when the dosage is too low, the decolorization effect will decrease. In the previous experimental research of the inventor, it was found that only after the activated carbon decolorization is first used and then the anionic macroporous resin decolorization is used, the pigment impurities in the Saururus chinensis extract can be effectively removed, so that the prepared composition can reach the color that meets the requirements; at the same time, the red-fading effect of the prepared composition is better. If only activated carbon decolorization or anionic macroporous resin decolorization is performed, or if the anionic macroporous resin is used for decolorization first and then the activated carbon decolorization is performed, the pigment removal effect in the Saururus chinensis extract will decrease to varying degrees, so that the color of the prepared composition becomes darker to varying degrees, and the red-fading effect of the composition is reduced to a certain extent.

[0036] In a second aspect, the present invention provides a use of the aforementioned composition in preparing cosmetics having redness-removing effect.

[0037] As a preferred embodiment, in the cosmetics having redness-removing effect, the added mass percentage of the aforementioned composition is 0.01 to 10%.

[0038] Compared with the prior art, the present invention has the following beneficial effects:

[0039] 1) The composition prepared by mixing the Saururus chinensis extract with a fat-soluble solvent has a very significant redness-removing effect.

[0040] 2) The present invention can further improve the redness-removing effect of the composition by specifically selecting the mixing ratio of the Saururus chinensis extract and the fat-soluble solvent and specifically selecting the type of the fat-soluble solvent.

[0041] 3) The present invention can further improve the redness-removing effect of the composition by further adopting the Saururus chinensis extract prepared by a specific process. BRIEF DESCRIPTION OF THE DRAWINGS

[0042] Other features, objects and advantages of the present invention will become more apparent from the detailed description of non-limiting embodiments made with reference to the following drawings:

[0043] Figure 1 The photographs are of the desorption liquid after enrichment, the filtrate after decolorization with activated carbon, and the eluate after decolorization with an anion resin in Example 2 of the present invention;

[0044] Figure 2 The results of the alleviating effect of 0.5% Y1 on skin redness induced by capsaicin, histamine, and methyl nicotinate;

[0045] Figure 3 The results of the alleviating effect of the tested product 0.5% Y2 on skin redness induced by capsaicin, histamine, and methyl nicotinate;

[0046] Figure 4 This is a case study showing the effect of 0.5% Y2 on the skin redness induced by capsaicin, histamine, and methyl nicotinate;

[0047] Figure 5 The results of the alleviating effect of the tested product 0.5% Y3 on skin redness induced by capsaicin, histamine, and methyl nicotinate;

[0048] Figure 6 The results of the alleviating effect of the tested product 0.5% Y4 on skin redness induced by capsaicin, histamine, and methyl nicotinate;

[0049] Figure 7The results of the alleviating effect of the tested product 0.5% Y5 on skin redness induced by capsaicin, histamine, and methyl nicotinate;

[0050] Figure 8 The results of the relieving effect of the tested product 0.5% Y6 on skin redness induced by capsaicin, histamine, and methyl nicotinate;

[0051] Fig. 9 The results show that 0.5% Y7, the tested product, alleviates skin redness induced by capsaicin, histamine, and methyl nicotinate.

[0052] Fig.10 The results of the alleviating effect of the tested product 0.5% Y8 on skin redness induced by capsaicin, histamine, and methyl nicotinate;

[0053] Fig.11 The results of the relieving effect of the tested product 0.5% Y9 on skin redness induced by capsaicin, histamine, and methyl nicotinate;

[0054] Fig.12 The results of the alleviating effect of the tested product 0.5% Y10 on skin redness induced by capsaicin, histamine, and methyl nicotinate;

[0055] Fig.13 The results of the alleviating effect of the tested product 0.5% Y11 on skin redness induced by capsaicin, histamine, and methyl nicotinate;

[0056] Fig.14 The results show that 0.5% Y12 of the tested product alleviates skin redness induced by capsaicin, histamine and methyl nicotinate.

[0057] Fig.15 The results show that 0.5% Y13, the tested product, alleviates skin redness induced by capsaicin, histamine, and methyl nicotinate.

[0058] Fig.16 The results show that 0.5% Y14, the tested product, alleviates skin redness induced by capsaicin, histamine, and methyl nicotinate.

[0059] Fig.17 The results show that 0.5% Y16, the tested product, alleviates skin redness induced by capsaicin, histamine, and methyl nicotinate. DETAILED DESCRIPTION

[0060] The present invention is described in detail below in conjunction with specific embodiments. The following embodiments will help those skilled in the art to further understand the present invention, but are not intended to limit the present invention in any form. It should be noted that, for those of ordinary skill in the art, several variations and improvements may be made without departing from the concept of the present invention. These all belong to the protection scope of the present invention.

[0061] The Chinese medicinal raw materials, reagents, etc. used in the experiment of the present invention are all provided by the company and / or purchased on the market. In the following examples, the percentage of ethanol used is the volume fraction. The content of saururus chinensis ketone in the raw material used is: 0.14%, the content of total lignans is: 0.3%, and the content of total terpenes is: 0.36%. Determination method: Saururus chinensis ketone adopts the 2020 edition of the "Chinese Pharmacopoeia", the total terpenes are determined by the total triterpenoid content in the health food method, and the total lignans are determined by UV-visible spectrophotometry.

[0062] Example 1

[0063] This embodiment provides a composition, comprising 3.5% by weight of Saururus chinensis extract and 96.5% by weight of caprylic / capric triglyceride (sample number Y1). The specific preparation steps of the composition are as follows:

[0064] 1. Extraction: Cut the raw material of Saururus chinensis (stems and leaves of Saururus chinensis) into sections, add 500.0 g of the raw material, add 5000 mL of 65% ethanol each time, reflux extract at 80-90°C for 1.5 h, extract twice, combine the extracts, cool to room temperature, and filter the extracts;

[0065] 2. Enrichment: Load the filtrate obtained in the extraction step onto 500 mL of D101 macroporous resin at a flow rate of 2.0 Bv / h; after loading, desorb with 1500 mL of 80% ethanol at a flow rate of 1.0 Bv / h, and collect the desorbed liquid;

[0066] 3. Decolorization: Add 2.0g of 200-300 mesh coconut shell activated carbon to the desorption liquid, stir for 30 minutes at room temperature for decolorization, and then filter with a 0.45um membrane; the obtained filtrate is then loaded onto LX-T5 anion resin (the volume ratio of the filtrate to the LX-T5 anion resin is 30:1) for decolorization, the column flow rate is 2.0Bv / h, the eluate is collected and the pH is adjusted to 6.9-7.1 with citric acid; the solution photos before and after decolorization are as follows Figure 1 shown.

[0067] 4. Concentration and drying: The eluate obtained in the decolorization step was concentrated and dried by vacuum concentration, with a vacuum degree of 0.09 MPa, a drying temperature of 60°C, and a drying time of 10 h. 4.0 g of extract (i.e., Saururus chinensis extract) was obtained, with a content of 8.4% of Saururus chinensis ketone and a yield of 48.0%; a content of 17% of total lignans and a yield of 45.3%; and a content of 20.0% of total terpenes and a yield of 44.4%.

[0068] 5. Dissolution with a fat-soluble solvent: Take 2.0 g of the extract, add caprylic / capric triglyceride at a concentration of 3.5%, dissolve and filter to obtain a composition with good stability.

[0069] Example 2

[0070] This embodiment provides a composition, comprising 3.5% by weight of Saururus chinensis extract and 96.5% by weight of caprylic / capric triglyceride (sample number Y2). The specific preparation steps of the composition are as follows:

[0071] 1. Extraction: Cut the raw material of Saururus chinensis (stems and leaves of Saururus chinensis) into sections, add 500.0 g of the raw material, add 5000 mL of 70% ethanol each time, reflux extract at 80-90°C for 1.5 h, extract twice, combine the extracts, cool to room temperature, and filter the extracts;

[0072] 2. Enrichment: Load the filtrate obtained in the extraction step onto 400 mL of D101 macroporous resin at a flow rate of 2.5 Bv / h; after loading, desorb with 1500 mL of 90% ethanol at a flow rate of 1.0 Bv / h, and collect the desorbed liquid;

[0073] 3. Decolorization: Add 2.0g 200-300 mesh coconut shell activated carbon to the desorption liquid, stir for 30 minutes at room temperature for decolorization, and then filter with a 0.45um membrane; the obtained filtrate is then loaded onto LX-T5 anion resin (the volume ratio of the filtrate to the LX-T5 anion resin is 30:1) for decolorization, the column flow rate is 2.0Bv / h, collect the eluate and adjust the pH to 6.9-7.1 with citric acid;

[0074] 4. Concentration and drying: The eluate obtained in the decolorization step was concentrated and dried under vacuum, with a vacuum degree of 0.09 MPa, a drying temperature of 60°C, and a drying time of 10 h. 4.5 g of extract (i.e., Saururus chinensis extract) was obtained, and the content of Saururus chinensis ketone was 14% and the yield was 66.8% by HPLC; the content of total lignans was 28% and the yield was 66.0%; the content of total terpenes was 25.0% and the yield was 32%.

[0075] 5. Dissolution with a fat-soluble solvent: Take 1.0 g of the extract, add caprylic / capric triglyceride at a concentration of 3.5%, dissolve and filter to obtain a composition with good stability.

[0076] Example 3

[0077] This embodiment provides a composition, including 3.5% by weight of Saururus chinensis extract and 96.5% by weight of caprylic / capric triglyceride (sample number Y3). The specific preparation steps of the composition are as follows:

[0078] 1. Extraction: Cut the raw material of Saururus chinensis (stems and leaves of Saururus chinensis) into sections, add 500.0 g of the raw material, add 5000 mL of 70% ethanol each time, reflux extract at 80-90°C for 1.5 h, extract twice, combine the extracts, cool to room temperature, and filter the extracts;

[0079] 2. Enrichment: Load the filtrate obtained in the extraction step onto 400 mL of D101 macroporous resin at a flow rate of 2.5 Bv / h; after loading, desorb with 1500 mL of 95% ethanol at a flow rate of 1.0 Bv / h, and collect the desorbed liquid;

[0080] 3. Decolorization: Add 2.0g of 200-300 mesh coconut shell activated carbon to the desorption liquid, stir for 30 minutes at room temperature for decolorization, and then filter with a 0.45um membrane; the obtained filtrate is then loaded onto LX-T5 anion resin (the volume ratio of the filtrate to the LX-T5 anion resin is 30:1) for decolorization, the column flow rate is 2.0Bv / h, collect the eluate and adjust the pH to 6.9-7.1 with citric acid;

[0081] 4. Concentration and drying: The eluate obtained in the decolorization step was concentrated and dried under vacuum, with a vacuum degree of 0.09 MPa, a drying temperature of 60°C, and a drying time of 10 h. 4.8 g of extract (i.e., Saururus chinensis extract) was obtained, and the content of Saururus chinensis ketone was 10.2% and the yield was 69.9% as determined by HPLC; the content of total lignans was 23% and the yield was 73.6%; the content of total terpenes was 25.5% and the yield was 68.0%.

[0082] 5. Dissolution with a fat-soluble solvent: Take 1.0 g of the extract, add caprylic / capric triglyceride at a concentration of 3.5%, dissolve and filter to obtain a composition with good stability.

[0083] Example 4

[0084] This example provides a composition, comprising 3.5% by weight of Saururus chinensis extract and 96.5% by weight of macadamia oil (sample number Y4). The specific preparation steps of the composition are substantially the same as those of Example 2, except that the caprylic / capric triglyceride in step 5 is replaced by macadamia oil.

[0085] Example 5

[0086] This embodiment provides a composition, including 3.5% by weight of Saururus chinensis extract and 96.5% by weight of octyldodecanol (sample number Y5). The specific preparation steps of the composition are basically the same as those of Example 2, except that the caprylic / capric triglyceride in step 5 is replaced by octyldodecanol.

[0087] Example 6

[0088] This example provides a composition, comprising 1% by weight of Saururus chinensis extract and 99% by weight of octyldodecanol (sample number Y6). The specific preparation steps of the composition are the same as those of Example 1.

[0089] Example 7

[0090] This embodiment provides a composition, including 10% by weight of Saururus chinensis extract and 90% by weight of octyldodecanol (sample number Y7). The specific preparation steps of the composition are the same as those of Example 1. In the composition prepared in this embodiment, the solubility of the Saururus chinensis extract is greatly reduced, and the color of the prepared composition is darker.

[0091] Example 8

[0092] This example provides a composition, comprising 5% by weight of Saururus chinensis extract and 95% by weight of octyldodecanol (sample number Y8). The specific preparation steps of the composition are the same as those of Example 1.

[0093] Example 9

[0094] This embodiment provides a composition, including 3.5% by weight of Saururus chinensis extract and 96.5% by weight of hexylene glycol (sample number Y9). The specific preparation steps of the composition are basically the same as those of Example 2, except that the caprylic / capric triglyceride in step 5 is replaced by hexylene glycol.

[0095] Example 10

[0096] This embodiment provides a composition, including 3.5% by weight of Saururus chinensis extract and 96.5% by weight of squalane (sample number Y10). The specific preparation steps of the composition are basically the same as those of Example 2, except that the caprylic / capric triglyceride in step 5 is replaced by squalane.

[0097] Embodiment 11

[0098] This example provides a composition, comprising 3.5% by weight of Saururus chinensis extract and 96.5% by weight of sunflower seed oil (sample number Y11). The specific preparation steps of the composition are substantially the same as those of Example 2, except that the caprylic / capric triglyceride in step 5 is replaced by sunflower seed oil.

[0099] Example 12

[0100] This embodiment provides a composition, including 3.5% by weight of Saururus chinensis extract and 96.5% of polyglycerol-2 triisostearate (sample number Y12). The specific preparation steps of the composition are basically the same as those of Example 2, except that the caprylic / capric triglyceride in step 5 is replaced by polyglycerol-2 triisostearate.

[0101] Embodiment 13

[0102] This embodiment provides a composition, including 3% by weight of Saururus chinensis extract and 97% by weight of caprylic / capric triglyceride (sample number Y13). The specific preparation steps of the composition are as follows:

[0103] 1. Extraction: Cut the raw material of Saururus chinensis (stems and leaves of Saururus chinensis) into sections, add 500.0 g of the raw material, add 6000 mL of 60% ethanol each time, reflux extract at 80-90°C for 1 hour, extract 3 times, combine the extracts, cool to room temperature, and filter the extracts;

[0104] 2. Enrichment: Load the filtrate obtained in the extraction step onto 1000 mL of LX-100B macroporous resin at a flow rate of 1.0 Bv / h; after loading, desorb with 6000 mL of 80% ethanol at a flow rate of 3.0 Bv / h, and collect the desorbed liquid;

[0105] 3. Decolorization: Add 1.0 g of 200-300 mesh coconut shell activated carbon to the desorption liquid, stir at 60°C for 20 min for decolorization, and then filter with a 0.45 um membrane; the obtained filtrate is then loaded onto LX-T5 anion resin (the volume ratio of the filtrate to the LX-T5 anion resin is 10:1) for decolorization, the column flow rate is 1.0 Bv / h, the eluate is collected and the pH is adjusted to 6.5-6.7 with citric acid; the color of the obtained decolorized liquid is basically the same as that in Example 1.

[0106] 4. Concentration and drying: The eluate obtained in the decolorization step was concentrated and dried by vacuum concentration at a vacuum degree of 0.05 MPa, a drying temperature of 50° C., and a drying time of 20 h to obtain 3.2 g of extract (i.e., Saururus chinensis extract).

[0107] 5. Dissolution with a fat-soluble solvent: Take 2.0 g of the extract, add caprylic / capric triglyceride at a concentration of 3%, dissolve and filter to obtain a composition with good stability.

[0108] Embodiment 14

[0109] This embodiment provides a composition, including 4% by weight of Saururus chinensis extract and 96% by weight of caprylic / capric triglyceride (sample number Y14). The specific preparation steps of the composition are as follows:

[0110] 1. Extraction: Cut the raw material of Saururus chinensis (stems and leaves of Saururus chinensis) into sections, add 500.0 g of the raw material, add 3000 mL of 70% ethanol each time, reflux extract at 80-90°C for 2 hours, extract twice, combine the extracts, cool to room temperature, and filter the extracts;

[0111] 2. Enrichment: Load the filtrate obtained in the extraction step onto 250 mL of LX-100B macroporous resin at a flow rate of 0.5 Bv / h; after loading, desorb with 250 mL of 90% ethanol at a flow rate of 0.5 Bv / h, and collect the desorbed liquid;

[0112] 3. Decolorization: Add 5.0 g of 200-300 mesh coconut shell activated carbon to the desorption liquid, stir for 30 min at 20°C for decolorization, and then filter with a 0.45 um membrane; the obtained filtrate is then loaded onto LX-T5 anion resin (the volume ratio of the filtrate to the LX-T5 anion resin is 30:1) for decolorization, the column flow rate is 3.0 Bv / h, the eluate is collected and the pH is adjusted to 6.7-6.9 with citric acid; the color of the obtained decolorized liquid is substantially the same as that in Example 1.

[0113] 4. Concentration and drying: The eluate obtained in the decolorization step was concentrated and dried by vacuum concentration at a vacuum degree of 0.05 MPa, a drying temperature of 70° C., and a drying time of 5 h to obtain 2.8 g of extract (i.e., Saururus chinensis extract).

[0114] 5. Dissolution with a fat-soluble solvent: Take 2.0 g of the extract, add caprylic / capric triglyceride at a concentration of 4%, dissolve and filter to obtain a composition with good stability.

[0115] Embodiment 15

[0116] This embodiment provides a composition, including 3.5% by weight of Saururus chinensis extract and 96.5% by weight of caprylic / capric triglyceride (sample number Y15). The specific preparation steps of the composition are as follows:

[0117] 1. Extraction: Cut the raw material of Saururus chinensis (stems and leaves of Saururus chinensis) into sections, add 300.0 g of the raw material, add 3000 mL of 50% ethanol each time, reflux extract at 80-90°C for 2 hours, extract twice, combine the extracts, cool to room temperature, and filter the extracts;

[0118] 2. Enrichment: Load the filtrate obtained in the extraction step onto 300 mL of D101 macroporous resin at a flow rate of 2.0 Bv / h; after loading, desorb with 600 mL of 70% ethanol at a flow rate of 1.0 Bv / h, and collect the desorbed liquid;

[0119] 3. Concentration and drying: The desorbed liquid obtained in the enrichment step was concentrated and dried by vacuum concentration, with a vacuum degree of 0.05 MPa, a drying temperature of 70° C., and a drying time of 8 h to obtain 0.5 g of extract (i.e., Saururus chinensis extract).

[0120] 4. Dissolving with a fat-soluble solvent: Take 0.4 g of the extract, add caprylic / capric triglyceride at a concentration of 3.5%, dissolve and filter to obtain a composition. Since this comparative example is not decolorized, the color of the prepared composition is darker than that of Example 1, and it is not very stable, and a precipitate is precipitated after being placed for 1 day.

[0121] Comparative Example 1

[0122] This comparative example provides a composition, comprising 0.3% by weight of triturate and 99.7% by weight of caprylic / capric triglyceride (sample number Y16). The specific preparation steps of the composition are as follows:

[0123] The specific steps are as follows: 20 mg of sauropodazone standard is taken, caprylic / capric triglyceride is added at a concentration of 0.3%, and the mixture is dissolved and filtered to obtain a composition.

[0124] Efficacy verification:

[0125] The compositions prepared in Examples 1-14 (sample numbers Y1 to Y14) and Comparative Example 1 (sample number Y16) were formulated into various products to be tested with a concentration of 0.5% of Saururus chinensis extract solution or Saururus chinensis ketone solution using matrix raw materials, and the formulation ratios of various products to be tested are shown in Table 1. The products to be tested prepared from the extracts prepared in Examples 1-15 are sequentially recorded as 0.5% Y1 to 0.5% Y14, and the product to be tested prepared from the composition prepared in Comparative Example 1 is recorded as 0.5% Y16.

[0126] Table 1

[0127]

[0128] The preparation steps of each product to be tested are as follows:

[0129] 1. Heat phase A and phase B to 80-85℃ respectively and stir evenly.

[0130] 2. Add phase A to phase B and homogenize for 3 minutes.

[0131] 3. Continue stirring until the temperature reaches about 40°C, then add phase C.

[0132] In addition, caprylic / capric triglyceride, macadamia nut oil, octyldodecanol, ethylene glycol, squalane, sunflower seed oil, and polyglyceryl-2 triisostearate were prepared using the above-mentioned matrix raw materials to prepare respective solvent control products with a corresponding concentration of 0.5%.

[0133] Each product to be tested and each solvent control product were subjected to clinical redness removal test. The clinical redness removal test models include capsaicin stimulation model, histamine stimulation model, and nicotinate methyl ester stimulation model. Among them, capsaicin, histamine, and nicotinate methyl ester were purchased from the market, and this study test was approved by the Ethics Committee of Shanghai Jiakai Co., Ltd. (Batch No.: JKC-2409-0051, JKC-2409-0052). The concentrations of capsaicin, histamine, and nicotinate methyl ester used were 200μg / mL, 20mg / mL, and 20mM, respectively.

[0134] The specific test plan is as follows:

[0135] ① After cleaning the inner arm, balance for 20 minutes and use a marker to mark the test area of ​​each group 3*3cm 2 , each test area is at least 1 cm apart;

[0136] ② Use the skin color measuring instrument (SkinColorCatch, brand: Delfin) to test the skin basic a* value (i.e. a* value 刺激前 ), 30 μL of stimulant was applied for 15 min, and the probe test a* value (i.e. a* value 刺激后 ), take a photo with Vplus, and record it as repair 0min.

[0137] ③ Then the sample group applied 25 μL of each test sample or solvent control sample; the irritant group did not apply any sample.

[0138] 30 minutes after applying each test sample or solvent control sample, the sample group and irritant group were tested again with probe a*

[0139] Value (i.e. a* value 修护后 ), take photos with Vplus, and record it as 30 minutes of repair.

[0140] The specific data analysis method is as follows:

[0141] The Δa* value of each sample group and stimulus group was calculated using the following formula:

[0142] Δa* value = a* value 修护后 -a* value 刺激前

[0143] Compared with the stimulus group, the change rate of Δa* value of the sample group was calculated using the following formula:

[0144] Δa* value change rate (%) = (Δa* value 样品组 / Δa* value 刺激物组 -1)*100%

[0145] Paired T-test, α=0.05, compared with the matrix group, *** represents P<0.001, ** represents P<0.01, * represents P<0.05, ns represents P>0.05.

[0146] After stimulation with each stimulant, the test results of the Δa* value change rate of each sample group are shown in Table 2. The Δa* value change rate of each solvent control group is less than 5%.

[0147] Table 2

[0148]

[0149] The results of the test product 0.5% Y1 on the relief of skin redness induced by capsaicin, histamine, and methyl nicotinate are as follows Figure 2 Compared with the stimulation groups of capsaicin, histamine, and methyl nicotinate, the change rates of Δa* value of 0.5% Y1 were -44.69%, -40.42%, and -30.04%, respectively.

[0150] The results of the test product 0.5% Y2 on the relief of skin redness induced by capsaicin, histamine, and methyl nicotinate are as follows Figure 3 and Figure 4 Compared with the stimulation groups of capsaicin, histamine, and methyl nicotinate, the change rates of Δa* value of 0.5% Y2 were -57.41%, -72.59%, and -48.81%, respectively.

[0151] The results of the test product 0.5% Y3 on the relief of skin redness induced by capsaicin, histamine, and methyl nicotinate are as follows Figure 5 Compared with the stimulation groups of capsaicin, histamine, and methyl nicotinate, the change rates of Δa* value of 0.5% Y3 were -61.37%, -67.04%, and -48.21%, respectively.

[0152] The results of the test product 0.5% Y4 on the relief of skin redness induced by capsaicin, histamine, and methyl nicotinate are as follows Figure 6 Compared with the stimulation groups of capsaicin, histamine, and methyl nicotinate, the change rates of Δa* value of 0.5% Y4 were -61.90%, -65.81%, and -47.47%, respectively.

[0153] The results of the test product 0.5% Y5 on the relief of skin redness induced by capsaicin, histamine, and methyl nicotinate are as follows Figure 7 Compared with the stimulation groups of capsaicin, histamine, and methyl nicotinate, the change rates of Δa* value of 0.5% Y5 were -51.19%, -53.33%, and -43.65%, respectively.

[0154] The results of the test product 0.5% Y6 on the relief of skin redness induced by capsaicin, histamine, and methyl nicotinate are as follows Figure 8Compared with the stimulation groups of capsaicin, histamine, and methyl nicotinate, the change rates of Δa* value of 0.5% Y6 were -17.45%, -10.82%, and -10.91%, respectively.

[0155] The results of the test product 0.5% Y7 on the relief of skin redness induced by capsaicin, histamine, and methyl nicotinate are as follows Fig. 9 Compared with the stimulation groups of capsaicin, histamine, and methyl nicotinate, the change rates of Δa* value of 0.5% Y7 were -40.92%, -22.77%, and -24.26%, respectively.

[0156] The results of the test product 0.5% Y8 on the relief of skin redness induced by capsaicin, histamine, and methyl nicotinate are as follows Fig.10 Compared with the stimulation groups of capsaicin, histamine, and methyl nicotinate, the change rates of Δa* value of 0.5% Y8 were -56.68%, -50.81%, and -49.74%, respectively.

[0157] The results of the test product 0.5% Y9 on the relief of skin redness induced by capsaicin, histamine, and methyl nicotinate are as follows Fig.11 Compared with the stimulation groups of capsaicin, histamine, and methyl nicotinate, the change rates of Δa* value of 0.5% Y9 were -46.74%, -42.89%, and -24.41%, respectively.

[0158] The results of the test product 0.5% Y10 on the relief of skin redness induced by capsaicin, histamine, and methyl nicotinate are as follows Fig.12 Compared with the stimulation groups of capsaicin, histamine, and methyl nicotinate, the change rates of Δa* value of 0.5% Y10 were -24.19%, -17.21%, and -6.25%, respectively.

[0159] The results of the test product 0.5% Y11 on the relief of skin redness induced by capsaicin, histamine, and methyl nicotinate are as follows Fig.13 Compared with the stimulation groups of capsaicin, histamine, and nicotinate methyl ester, the change rates of Δa* value of 0.5% Y11 were -65.72%, -54.17%, and -43.01%, respectively.

[0160] The results of the test product 0.5% Y12 on the relief of skin redness induced by capsaicin, histamine, and methyl nicotinate are as follows Fig.14 Compared with the stimulation groups of capsaicin, histamine, and methyl nicotinate, the change rates of Δa* value of 0.5% Y12 were -57.82%, -54.94%, and -49.87%, respectively.

[0161] The results of the test product 0.5% Y13 on the relief of skin redness induced by capsaicin, histamine, and methyl nicotinate are as follows Fig.15Compared with the stimulation groups of capsaicin, histamine, and nicotinate methyl ester, the change rates of Δa* value of 0.5% Y13 were -55.13%, -44.41%, and -35.94%, respectively.

[0162] The results of the test product 0.5% Y14 on the relief of skin redness induced by capsaicin, histamine, and methyl nicotinate are as follows Fig.16 Compared with the stimulation groups of capsaicin, histamine, and methyl nicotinate, the change rates of Δa* value of 0.5% Y14 were -53.68%, -47.25%, and -42.19%, respectively.

[0163] The results of the test product 0.5% Y16 on the relief of skin redness induced by capsaicin, histamine, and methyl nicotinate are as follows Fig.17 Compared with the stimulation groups of capsaicin, histamine, and nicotinate methyl ester, the change rates of Δa* value of 0.5% Y16 were -26.89%, -14.08%, and -5.21%, respectively.

[0164] The present invention has many specific application paths, and the above is only a preferred embodiment of the present invention. It should be pointed out that the above embodiments are only used to illustrate the present invention, and are not used to limit the protection scope of the present invention. For those of ordinary skill in the art, several improvements can be made without departing from the principle of the present invention, and these improvements should also be regarded as the protection scope of the present invention.

Claims

1. A composition having redness-removing effect, characterized in that: The invention comprises the following components in percentage by weight: 90-99% of fat-soluble solvent and 1-10% of Saururus chinensis extract; The fat-soluble solvent is selected from at least one of hexylene glycol, caprylic / capric triglyceride, sunflower seed oil, macadamia nut oil, meadowfoam seed oil, silicone oil, squalane, ethylhexyl palmitate, diisostearyl malate, polyglyceryl-2 triisostearate, camelina seed oil, octyldodecanol, and coconut oil caprylate / caprate.

2. The composition having redness-removing effect according to claim 1, characterized in that: The invention comprises the following components in percentage by weight: 95-97% of fat-soluble solvent and 3-5% of Saururus chinensis extract.

3. The composition having redness-removing effect according to claim 1, characterized in that: The fat-soluble solvent is selected from at least one of caprylic / capric triglyceride, macadamia nut oil, and octyldodecanol.

4. The composition having redness-removing effect according to claim 1, characterized in that: The Saururus chinensis extract is a fat-soluble Saururus chinensis extract.

5. The composition having redness-removing effect according to claim 4, characterized in that: The Saururus chinensis extract is prepared by the following method: The raw material of Saururus chinensis is extracted with alcohol, then filtered, adsorbed with resin, desorbed with alcohol, concentrated and dried to obtain the product.

6. The composition having redness-removing effect according to claim 5, characterized in that: The alcohol is selected from at least one of ethanol, propanol, butanol, glycerol and butanediol; The resin is a macroporous resin.

7. The composition having redness-removing effect according to claim 5, characterized in that: After the alcohol desorption step, a decolorization step is also included.

8. The composition with redness-removing effect according to claim 5, 6 or 7, characterized in that: The preparation method of the Saururus chinensis extract comprises the following steps: A1. Extraction: Cut the raw material of Saururus chinensis into sections and perform reflux extraction with 60-70% ethanol by volume; A2. Enrichment: The extract obtained in step A1 is filtered, and the obtained filtrate a is subjected to macroporous resin, and then desorbed with 80-95% ethanol by volume, and the desorbed liquid is collected, concentrated and dried to obtain the Saururus chinensis extract.

9. The composition having redness-removing effect according to claim 8, characterized in that: In step A2, the collected desorption liquid is further subjected to a decolorization step before being concentrated and dried; The decolorization step is specifically as follows: the desorption liquid is first decolorized with activated carbon and then filtered, the obtained filtrate b is then decolorized with an anionic macroporous resin, the decolorized liquid is collected and the pH is adjusted to 6.5-7.

1.

10. Use of the composition according to any one of claims 1 to 9 in the preparation of cosmetics with redness-removing effect, wherein the addition amount of the composition is 0.01 to 10%.

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