A composition specially used for resisting superficial fungal and bacterial infections and its preparation method

Abstract

The present invention discloses a composition and a preparation method thereof for specifically resisting superficial fungal bacterial infection. It mainly includes an antibacterial agent, a synergist, a repair agent, and a solubilizing agent. The antibacterial agent component is ε-polylysine hydrochloride; the synergist component is oxymatrine, hexylene glycol, octyl glycol, and sodium diacetate; the repair agent component is glycerol, urea, allantoin, and dipotassium glycyrrhizinate; the solubilizing agent component is Triton X-100, polyvinyl pyrrolidone, sodium pyrrolidone carboxylate, sodium pyrithione, and polyvinyl alcohol. The present invention uses antibacterial components from food grade and traditional Chinese medicine sources, no hormones and irritants, no corrosiveness, and is friendly to the human body. At the same time, the composition of the present invention is water-soluble, spray-type, easy to use, can soften keratin and dead skin, has good permeability, and continuously exerts fungicidal and bacterial effects to achieve the purpose of curing the root cause.

Description

Technical Field

[0001] The invention relates to the field of antibacterial infection, and in particular to a composition that can be used for superficial fungal and bacterial infections of the skin and a preparation method thereof. Background Art

[0002] Superficial fungal infection is the most common fungal infectious disease, including tinea pedis (athlete's foot), tinea cruris, tinea corporis, scalp tinea, onychomycosis (onychomycosis), etc. Among them, athlete's foot is one of the most common fungal infectious lesions of the skin, with symptoms such as foot sweat, foot odor, itching, blistering, cracking, peeling and even pain in the affected area. Due to the hot and humid environment of the feet, fungi and bacteria can easily multiply rapidly between the toes and in the folds of the skin. At the same time, due to the penetration of microorganisms into the skin and the patient's own scratching, athlete's foot is prone to recurrence and spread. Although skin infections such as athlete's foot are not serious infectious diseases, such infections bring serious inconvenience to people's lives and affect people's mental health and quality of life.

[0003] The pathogens of skin infections such as tinea cruris, tinea corporis, and tinea pedis are mainly fungi, among which the most common are one or more of the four types of Trichophyton (Trichophyton rubrum and Trichophyton violaceum), Trichophyton gypseum, Epidermophyton floccosum, and Candida albicans. It is also easy to be mixed with bacterial infections, such as Staphylococcus aureus and Streptococcus. The fundamental method to treat athlete's foot is to eliminate the growth and reproduction environment of such microorganisms and give antibacterial drugs that cure the root cause. Taking athlete's foot as an example, many antifungal creams for treating athlete's foot are currently only effective against fungi, but not against bacteria. In addition, the creams are not easy to apply in the gaps between toes and nails, and are mainly fat-soluble and have poor permeability. Many spray preparations contain acidic ingredients (salicylic acid, glacial acetic acid, benzoic acid, etc.), phenols (such as phenol), aldehydes (such as formaldehyde), and hormones (such as dexamethasone), which are irritating or corrosive to the skin. Many Chinese medicines and plant extracts for treating athlete's foot have complex formulas, and the ingredients are not stable and clear, which is not conducive to quality assurance. Summary of the invention

[0004] The technical problem to be solved by the present invention is to provide a composition specially used for resisting superficial fungal and bacterial infections, the main component of which is ε-polylysine hydrochloride, which is a water-soluble nutritional biological preservative with good permeability, high safety and good antibacterial effect.

[0005] In order to solve the above technical problems, the technical solution adopted by the present invention is:

[0006] A composition specially used for resisting superficial fungal and bacterial infections. The composition mainly comprises an antibacterial agent, a synergist, a repairing agent and a solubilizing agent. Every 1000 parts by weight of the composition comprises the following components in parts by weight: antibacterial agent: 1-3 parts; synergist: 2-6 parts; repairing agent: 5-10 parts; solubilizing agent: 5-10 parts; and the balance is water.

[0007] Wherein, the antibacterial agent is ε-polylysine hydrochloride (molecular weight 4130-5776). The synergist is one of oxymatrine, hexylene glycol, caprylyl glycol, sodium diacetate or a mixture of two or more thereof. The repair agent is one of glycerol, urea, allantoin, dipotassium glycyrrhizinate or a mixture of two or more thereof. The solubilizer is one of Triton X-100, polyvinyl pyrrolidone, sodium pyrrolidone carboxylate, sodium pyrithione, polyvinyl alcohol or a mixture of two or more thereof.

[0008] The present invention also provides a method for preparing the above composition: the preparation process of each 1000 parts by weight of the composition is as follows: A. weigh the antibacterial agent, synergist and repair agent in the above mentioned parts by weight, add about 500 parts by weight of tap water and stir at room temperature and pressure; B. add the above mentioned parts by weight of the solubilizer to the mixture in step A, add tap water to 1000 parts by weight and stir to dissolve at room temperature and pressure.

[0009] The beneficial effects that the present invention can achieve are:

[0010] 1. The antibacterial main component ε-polylysine hydrochloride used in the present invention is a water-soluble nutritional biological preservative with good permeability, high safety, good antibacterial effect, broad antibacterial spectrum, high temperature resistance and can be decomposed into nutrient lysine in the stomach and intestines. In vitro antimicrobial experiments show that the antibacterial component has a good bactericidal effect on common trichophyton, flocculent epidermophyton, gypsum-like tinea, Candida and Staphylococcus aureus in skin infections, and is an ideal substance for treating superficial fungal and bacterial infections such as athlete's foot. At the same time, the present invention uses a synergist to assist in sterilization to achieve a synergistic bactericidal effect.

[0011] 2. The repairing agent used in the present invention can soften the stratum corneum and dead skin of the affected skin, allowing the antibacterial ingredients to quickly penetrate deep into the skin to achieve a good antibacterial effect. It also has the effects of anti-inflammation, wound repair and skin regeneration.

[0012] 3. The present invention provides a composition specially used for resisting superficial fungal and bacterial infections and a preparation method thereof. The composition has no hormone components, is non-corrosive, has a suitable smell, and has good permeability and moisturizing properties. The composition is in a spray form, is easy to use, and is easy for patients to accept. DETAILED DESCRIPTION

[0013] The following examples are used to explain the present invention, but are not limited thereto.

[0014] A composition specially used for resisting superficial fungal and bacterial infections. The composition mainly comprises an antibacterial agent, a synergist, a repairing agent and a solubilizing agent. Every 1000 parts by weight of the composition comprises the following components in parts by weight: antibacterial agent: 1-3 parts; synergist: 2-6 parts; repairing agent: 5-10 parts; solubilizing agent: 5-10 parts; and the balance is water.

[0015] Wherein, the antibacterial agent is ε-polylysine hydrochloride, with a molecular weight of 4130-5776, which is the main antibacterial component and plays a role in killing and inhibiting fungi and bacteria. The synergist is one or more mixtures of oxymatrine, hexylene glycol, octyl glycol, sodium diacetate, and this component is a novel and safe preservative, which plays a synergistic auxiliary role in the present invention. The repair agent is one or more mixtures of glycerol, urea, allantoin, and dipotassium glycyrrhizinate, and the repair agent has the effects of moisturizing, softening dead skin keratin and preventing skin cracking. Among them, allantoin and dipotassium glycyrrhizinate have anti-inflammatory effects and can reduce skin redness, swelling and itching. At the same time, it can promote cell synthesis of collagen and accelerate the healing of skin ulcers. The solubilizer is one or more mixtures of Triton X-100, polyvinyl pyrrolidone, sodium pyrrolidone carboxylate, sodium pyridinethione, and polyvinyl alcohol, and its function is to increase the compatibility between the components and improve the stability of the solution. The above components are all commercially available products.

[0016] The present invention also provides a method for preparing the above composition: the preparation process of each 1000 parts by weight of the composition is as follows: A. weigh the antibacterial agent, synergist and repair agent in the above mentioned parts by weight, add about 500 parts by weight of tap water and stir at room temperature and pressure; B. add the above mentioned parts by weight of the solubilizer to the mixture in step A, add tap water to 1000 parts by weight and stir to dissolve at room temperature and pressure.

[0017] The present invention is described in detail below with reference to specific embodiments. Example

[0018] A composition specially used for resisting superficial fungal and bacterial infections, the composition consists of ε-polylysine hydrochloride, caprylyl glycol, glycerol, allantoin, Triton X-100 and polyvinyl pyrrolidone.

[0019] To prepare 1 kg of the spray of the composition, weigh the components as follows:

[0020] ε-polylysine hydrochloride 3.0 g;

[0021] Caprylyl glycol 5.0 g;

[0022] Glycerol 5.0 g;

[0023] Allantoin 5.0 g;

[0024] Polyvinylpyrrolidone 5.0 g;

[0025] Triton X-100 5.0 g;

[0026] Add water to 1 Kg.

[0027] The spray preparation process of the composition is as follows:

[0028] A. First, mix the above weights of ε-polylysine hydrochloride, caprylyl glycol, glycerol, allantoin, and polyvinylpyrrolidone evenly, then add about 0.5 kg of water and stir at room temperature and pressure;

[0029] B. Add the above weight of Triton X-100 to the mixture in step A, and then add up to 1 kg. Stir thoroughly for half an hour at room temperature and pressure, and let it stand to obtain the finished product. Example

[0030] A composition specially used for resisting superficial fungal and bacterial infections and a preparation method thereof. The composition consists of ε-polylysine hydrochloride, oxymatrine, hexylene glycol, urea, dipotassium glycyrrhizinate, sodium pyrithione and sodium pyrrolidone carboxylate.

[0031] To prepare 1 kg of the spray of the composition, weigh the components according to the following weight or volume:

[0032] ε-Poly-lysine hydrochloride 2.5 g;

[0033] Oxymatrine 3.0g;

[0034] Hexanediol 3.0 g;

[0035] Urea 5.0 g;

[0036] Dipotassium glycyrrhizinate 2.0 g;

[0037] Sodium pyrithione 3.0 g;

[0038] Sodium pyrrolidonecarboxylate 5.0 g;

[0039] Add water to 1 Kg.

[0040] The spray preparation process of the composition is as follows:

[0041] A. First, mix the above weights of ε-polylysine hydrochloride, urea, dipotassium glycyrrhizinate, sodium pyrithione, and sodium pyrrolidone carboxylate, and then add about 0.5 kg of water and stir at room temperature and pressure;

[0042] B. Add the above weights of oxymatrine and hexylene glycol to the mixture in step A, add water to 1 kg, stir thoroughly for half an hour at room temperature and pressure, and let stand to obtain the finished product. Example

[0043] A composition specially used for resisting superficial fungal bacterial infection and a preparation method thereof. The composition consists of ε-polylysine hydrochloride, oxymatrine, sodium diacetate, allantoin and polyvinyl alcohol.

[0044] To prepare 1 kg of the spray of the composition, weigh the components as follows:

[0045] ε-Poly-lysine hydrochloride 1.0 g;

[0046] Oxymatrine 1.0 g;

[0047] Sodium diacetate 1.0 g;

[0048] Allantoin 5.0 g;

[0049] Polyvinyl alcohol 5.0 g;

[0050] Add tap water to 1 kg.

[0051] The spray preparation process of the composition is as follows:

[0052] A. First, mix the above weights of ε-polylysine hydrochloride, oxymatrine, sodium diacetate, and allantoin evenly, then add about 0.5 kg of water and stir at room temperature and pressure;

[0053] B. Add the above weight of polyvinyl alcohol to the mixture in step A, and then add water to make the volume 1 kg, stir thoroughly for half an hour at room temperature and pressure, and let it stand to obtain the finished product. Example

[0054] A composition specially used for resisting superficial fungal bacterial infection and a preparation method thereof. The composition consists of ε-polylysine hydrochloride, hexylene glycol, caprylyl glycol, allantoin, dipotassium glycyrrhizinate, polyvinyl pyrrolidone and sodium pyrithione.

[0055] To prepare 1 kg of the spray of the composition, weigh the components as follows:

[0056] ε-Poly-lysine hydrochloride 1.5 g;

[0057] Hexanediol 4.0 g;

[0058] Caprylyl glycol 2.0 g;

[0059] Allantoin 3.0 g;

[0060] Dipotassium glycyrrhizinate 2.0 g;

[0061] Polyvinylpyrrolidone 5.0 g;

[0062] Sodium pyrithione 5.0 g;

[0063] Add tap water to 1 Kg.

[0064] The spray preparation process of the composition is as follows:

[0065] A. First, mix the above weights of ε-polylysine hydrochloride, hexylene glycol, caprylyl glycol, allantoin and dipotassium glycyrrhizinate evenly, then add about 0.5 kg of water and stir at room temperature and pressure;

[0066] B. Add the above weights of polyvinyl pyrrolidone and sodium pyrithione to the mixture in step A, and then add water to make the volume to 1 kg. Stir thoroughly for half an hour at room temperature and pressure, and let it stand to obtain the finished product. Example

[0067] A composition specially used for resisting superficial fungal and bacterial infections and a preparation method thereof, the composition comprises ε-polylysine hydrochloride, oxymatrine, caprylyl glycol, sodium diacetate, urea,

[0068] It is composed of dipotassium glycyrrhizinate, Triton X-100 and sodium pyrithione.

[0069] To prepare 1 kg of the spray of the composition, weigh the components as follows:

[0070] ε-polylysine hydrochloride 1.0 g;

[0071] Oxymatrine 2.0 g;

[0072] Caprylyl glycol 2.0;

[0073] Sodium diacetate 2.0 g;

[0074] Urea 3.0 g;

[0075] Dipotassium glycyrrhizinate 5.0 g;

[0076] Triton X-100 5.0 Kg;

[0077] Sodium pyrithione 5.0 g;

[0078] Add tap water to 1 Kg.

[0079] The spray preparation process of the composition is as follows:

[0080] A. First, mix the above weights of ε-polylysine hydrochloride, oxymatrine, caprylyl glycol, sodium diacetate, urea, and dipotassium glycyrrhizinate uniformly, then add about 0.5 kg of water and stir at room temperature and pressure;

[0081] B. Add the above weights of Triton X-100 and sodium pyrithione to the mixture in step A, and then add water to make the volume to 1 kg. Stir well for half an hour at room temperature and pressure, and let it stand to obtain the finished product.

[0082] In order to verify the effect of the embodiments of the present invention, the antibacterial effect of the compositions specially used for resisting superficial fungal and bacterial infections in Examples 1, 2, 3, 4, and 5 was tested on common microorganisms in tinea cruris, tinea corporis, tinea pedis, and tinea capitis. The following results were obtained from Table 1: Compositions ①-⑤ configured according to the above embodiments have good inhibitory or killing effects on Trichophyton rubrum, Epidermophyton floccosum, Gypsum gypseum, Candida albicans, and Staphylococcus aureus.

[0083] Microbial species ① ② ③ ④ ⑤ Trichophyton rubrum 42 50 49 48 59 Epidermophyton floccosum 42 40 39 40 46 Gypsum gypseum 31 33 30 31 34 Candida albicans 42 42 41 42 36 Staphylococcus aureus 24 25 24 26 22

[0084] Composition concentration: stock solution diluted 5 times

[0085] The diameter of the antibacterial ring (the average of three measurements), in mm, is 6 mm for the control group without antifungal agent (i.e. the diameter of the blank paper itself).

[0086] 2. Use observation

[0087] 2.1 Before treatment, all subjects were subjected to clinical direct microscopic examination, and all were positive, and were diagnosed with tinea. Then, the No. 4 composition of the fourth embodiment, which is specially used for resisting superficial fungal and bacterial infections, was applied to the affected area 2 to 3 times a day; clinical observation and direct microscopic examination were performed once every two weeks. Among the 106 cases with complete data, there were 32 males and 74 females. According to the disease type, there were 23 cases of tinea cruris, 27 cases of tinea corporis, and 56 cases of tinea pedis, and the same patient suffered from 1 to 3 diseases.

[0088] 2.2 Efficacy criteria

[0089] Healed - skin lesions disappear, local fungal scrapings and microscopic examination are negative

[0090] Improvement - Skin lesions improve, lesions disappear, and subjective symptoms are alleviated, but a small amount of hyphae in fungal scrapings are still positive.

[0091] Ineffective: subjective symptoms and skin lesions did not improve, and fungal scraping microscopy was still positive.

[0092] 2.3 Treatment outcomes

[0093] 89 cases were cured, accounting for 84%, 11 cases were improved, accounting for 10.4%, and 6 cases were ineffective, accounting for 5.6%. The total effective rate was 94.4%. The fastest improvement time for clinical manifestations was 3 days, the healing time was generally 7 to 10 days, and the slowest was 45 days. In some ineffective and improved cases, due to the large area of ​​​​lesions and failure to adhere to the medication, the 2 ineffective cases had local allergic reactions, causing erythema and discontinuation of use.

[0094] Observations on use have shown that composition No. 4, which is specifically used to resist superficial fungal and bacterial infections, is effective in treating skin tinea caused by fungi, such as tinea cruris, tinea corporis, and tinea pedis. The composition is simple to prepare, easy to use, and has little irritation to the skin, and is worthy of promotion.

[0095] The embodiments described in the present invention are for illustrative purposes only and are not intended to limit the scope of protection of the present invention. Those skilled in the art may make various other substitutions, changes and improvements within the scope of the present invention. Therefore, the present invention is not limited to the above embodiments, but is only limited by the claims.

Claims

1. A composition specially used for resisting superficial fungal and bacterial infections, the composition mainly comprises an antibacterial agent, a synergist, a repair agent and a solubilizer, characterized in that: Each 1000 parts by weight of the composition includes the following parts by weight of each component: Antimicrobial agent: 1-3 parts; Synergist: 2-6 parts; Restorative agent: 5-10 parts; Solubilizer: 5-10 parts; The balance is water, Among them, the antibacterial agent is ε-polylysine hydrochloride; the synergist is one of oxymatrine, hexylene glycol, caprylyl glycol, sodium diacetate or a mixture of two or more; the repair agent is one of glycerol, urea, allantoin, dipotassium glycyrrhizinate or a mixture of two or more; the solubilizer is one of Triton X-100, polyvinyl pyrrolidone, sodium pyrrolidone carboxylate, sodium pyrithione, polyvinyl alcohol or a mixture of two or more.

2. According to the method for preparing a composition specifically used for resisting superficial fungal and bacterial infections as claimed in claim 1, the preparation process of each 1000 parts by weight of the composition is as follows: A. Weigh the antibacterial agent, synergist and repair agent in the above weight parts, add about 500 weight parts of tap water and stir at room temperature and pressure; B. Add the solubilizer in parts by weight to the mixture in step A, add tap water to 1000 parts by weight, and stir thoroughly to dissolve at room temperature and pressure.