A bacteriostatic and antibacterial Yi medicine formula and its production process

Abstract

The present invention relates to a kind of antibacterial and antimicrobial Yi medicine formula and its production process, belong to the technical field of drug preparation, a kind of antibacterial and antimicrobial Yi medicine formula, including the following parts by mass: 80-100 parts of sophora flavescens, 80-100 parts of scutellaria baicalensis, 80-100 parts of blood-filled grass, 80-100 parts of Senecio chinensis, 5-8 parts of system stabilizers, 2000-3000 parts of drinking water, 1-6 parts of essences and 1-2 parts of composite strains; wherein the system stabilizer includes polyhexamethylene guanidine, oligoxylose and liposome. The present invention adopts Chinese medicinal materials such as sophora flavescens and scutellaria baicalensis to enhance synergy and antibacterial, cooperates with polyhexamethylene guanidine, oligoxylose and liposome to stabilize the system, utilizes plant lactobacillus and bifidobacterium adolescentis composite strain fermentation, liposome improves extraction efficiency, and each part acts synergistically to jointly enhance the antibacterial effect, stability and health care function of antibacterial liquid.

Description

Technical Field

[0001] The present application relates to the technical field of drug preparation, and more specifically, to a bacteriostatic and antibacterial Yi medicine formula and its production process. Background Art

[0002] As an important part of traditional Chinese medicine, Yi medicine has a long history and profound cultural heritage. It combines the long-term life experience and medical practice of the Yi people to form a unique drug formula and preparation process. In recent years, with the in-depth research and development of traditional Chinese medicine theory, the application of Yi medicine in the field of antibacterial and antimicrobial has gradually received attention.

[0003] In modern society, with the continuous improvement of people's health awareness, the demand for natural, non-toxic and antibacterial products is increasing. However, many antibacterial products on the market currently have technical problems such as poor system stability and insufficient antibacterial stability, which greatly limits their effects in practical applications. In order to solve these problems, the present invention proposes a formula of antibacterial Yi medicine and its production process, aiming to provide a kind of Yi medicine antibacterial product with high efficiency, stability and no toxic and side effects.

[0004] Based on the above statements, the present application provides an antibacterial and antimicrobial Yi medicine formula and its production process, aiming to solve the technical problems of existing antibacterial products such as poor system stability and insufficient antibacterial stability. Summary of the invention

[0005] In order to solve the problems raised in the background technology, the present application provides a bacteriostatic and antibacterial Yi medicine formula and its production process. The present invention adopts a combination of Chinese medicinal materials such as Sophora flavescens and Herba Polygoni Multiflori for antibacterial synergy, cooperates with polyhexamethylene guanidine, oligoxylose and liposome stabilization system, utilizes plant lactobacillus and bifidobacterium adolescentis composite strain fermentation, and liposome improves extraction efficiency, and each part works synergistically to jointly enhance the antibacterial effect, stability and health care function of the antibacterial liquid.

[0006] The present application provides a bacteriostatic and antibacterial Yi medicine formula and its production process, which adopts the following technical solutions:

[0007] A bacteriostatic and antibacterial Yi medicine formula, comprising the following raw materials in parts by weight:

[0008] 80-100 parts of Sophora flavescens, 80-100 parts of Radix schizonepetae, 80-100 parts of Herba Lycopodii, 80-100 parts of Radix Senecio, 5-8 parts of system stabilizer, 2000-3000 parts of drinking water, 1-6 parts of essence and 1-2 parts of composite bacteria;

[0009] The system stabilizers include polyhexamethylene guanidine, xylooligosaccharides and liposomes.

[0010] Furthermore, the system stabilizer is obtained by mixing polyhexamethylene guanidine, xylooligosaccharide and liposome in a mass ratio of 10:(3-7):(1-3).

[0011] Furthermore, the liposome is at least one of phosphatidylcholine liposome, ceramide liposome and hyaluronic acid liposome.

[0012] A production process of an antibacterial and antimicrobial Yi medicine comprises the following steps:

[0013] S1, collect Chinese medicinal materials of Sophora flavescens, Herba scutellariae, Herba Ligustici Chuanxiong, wash and dry them, check their appearance and properties, then weigh them, transfer them to the production workshop after verification, slice, grind, crush and sieve them to obtain plant raw material powder;

[0014] S2, adding the plant raw material powder obtained in step S1 into deionized water, stirring evenly, soaking for 1-3 hours, then heating to boiling, and then cooling to room temperature to obtain a primary extraction system;

[0015] S3, mixing the primary extraction system, system stabilizer and composite bacteria obtained in step S1, and then fermenting and filtering to obtain a secondary extraction system;

[0016] S4. Add drinking water and essence to the secondary extraction system obtained in step S3, followed by stirring, filtering and packaging after properties and pH value testing to obtain an antibacterial and antimicrobial Yi medicine.

[0017] A production process of an antibacterial and antimicrobial Yi medicine comprises the following steps:

[0018] S1, collect the Chinese medicinal materials of Sophora flavescens, Herba scutellariae, Herba Ligustici Chuanxiong, and Herba Senecio, then wash the above Chinese medicinal materials with deionized water and dry them naturally, check their appearance and properties, and then weigh them. After verification, transfer them to the production workshop, slice, grind, crush, and pass through an 80-mesh sieve to obtain plant raw material powder;

[0019] S2, adding the plant raw material powder obtained in step S1 into deionized water at a mass volume ratio of 1 g: (5-10) mL, stirring evenly, soaking for 1-3 hours, then heating to boiling, and then cooling to room temperature to obtain a primary extraction system;

[0020] S3, mixing the primary extraction system, system stabilizer and composite bacteria obtained in step S1, and then fermenting and filtering to obtain a secondary extraction system;

[0021] S4. Transfer the secondary extraction system obtained in step S3 to a liquid preparation tank, add drinking water and essence, then stir at room temperature until uniform, and after testing the properties and pH value, filter and package to obtain an antibacterial and antimicrobial Yi medicine.

[0022] Furthermore, in step S3, the composite bacteria is obtained by mixing Lactobacillus plantarum and Bifidobacterium adolescentis in a mass ratio of 1:(0.1-0.3).

[0023] Furthermore, in step S3, the inoculation amount of the composite bacteria is 3-7%.

[0024] Furthermore, in step S3, during the fermentation process, the fermentation temperature is set to 35-40° C. and the fermentation time is set to 48-72 hours.

[0025] In summary, this application has the following beneficial effects:

[0026] In the technical solution of the present invention, Sophora flavescens, Herba scutellariae, Herba scutellariae, and Herba scutellariae are used as components of the raw materials of the antibacterial liquid. Each of these Chinese medicinal materials has unique antibacterial, anti-inflammatory, and antioxidant effects. Combining them together can enhance each other's synergy and improve the overall antibacterial effect. For example, Sophora flavescens has a broad-spectrum antibacterial effect and can inhibit the growth of a variety of bacteria; Herba scutellariae can relax muscles and promote local blood circulation; Herba scutellariae has an anti-inflammatory effect and can reduce inflammatory reactions; Herba scutellariae can clear away heat, detoxify, and improve eyesight. The synergistic effect of these components makes the prepared antibacterial liquid have stronger antibacterial, anti-inflammatory and health-care effects.

[0027] In the technical solution of the present invention, polyhexamethylene guanidine, oligoxylose and liposomes are used as system stabilizers in the antibacterial liquid. This system stabilizer can enhance the stability of the antibacterial liquid, ensure that it is not easy to change its properties during storage and use, and avoid stratification, precipitation or reduced activity of the system. During the fermentation process, the above-mentioned system stabilizer participates in the fermentation process. The polyhexamethylene guanidine in the component has a broad-spectrum antibacterial property, which can effectively inhibit the growth of miscellaneous bacteria and ensure the purity of the fermentation process; oligoxylose as a carbon source can regulate the microbial activity in the fermentation process and promote the growth of beneficial bacteria; liposomes can be used as a carrier to help the effective ingredients to be better dispersed and stabilized, and improve the fermentation efficiency and product quality. Among the components, oligoxylose is not easily hydrolyzed by enzymes, has higher stability, and can provide a long-lasting and stable energy source for probiotics. At the same time, oligoxylose also has the health functions of regulating skin flora and enhancing immunity, which helps to improve the added value and health care effects of the prepared antibacterial liquid product.

[0028] In the technical solution of the present invention, a composite strain including Lactobacillus plantarum and Bifidobacterium adolescentis is used to ferment the Chinese medicinal material raw material. The composite strain can produce a variety of antibacterial substances, has a wider antibacterial spectrum, and has an inhibitory effect on a variety of bacteria, fungi and other microorganisms. At the same time, the interaction between different strains can also improve the stability and activity of the fermentation liquid, further enhancing its antibacterial effect.

[0029] In the technical solution of the present invention, a composite strain composed of plant lactobacillus and adolescent bifidobacterium and a system stabilizer composed of polyhexamethylene guanidine, oligoxylose and liposomes show synergistic effects. The liposomes and plant components are crushed together to extract the antibacterial components. Liposome technology can be used as an effective carrier to encapsulate the antibacterial components in plants, thereby improving their extraction efficiency. Since liposomes have a structure and function similar to that of cell membranes, they can more easily interact with plant cells, making it easier for the antibacterial components to be released and extracted. And the antibacterial components are encapsulated in liposomes, which can slow down their degradation rate and extend their shelf life. The composite strain produces antibacterial substances through fermentation, and the system stabilizer can protect these antibacterial substances from being destroyed by the external environment and maintain their activity. At the same time, oligoxylose as a carbon source can also promote the growth and reproduction of the composite strain, further enhancing its antibacterial ability. These two parts can promote each other and jointly improve the antibacterial effect and stability of the antibacterial liquid. DETAILED DESCRIPTION

[0030] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0031] The specific implementation methods of this application involve:

[0032] Lactobacillus plantarum: ATCC 8014, with a content of 10 billion cfu / g;

[0033] Bifidobacterium adolescentis: ATCC 15706, with a content of 10 billion cfu / g;

[0034] Lecithin liposomes: mesh size is 120 mesh, purity is 99.0%;

[0035] Ceramide Liposome: Ceramide fine powder, content is 5%;

[0036] Fragrance: Medicinal lemon flavor.

[0037] Example 1

[0038] A bacteriostatic and antibacterial Yi medicine formula, comprising the following raw materials in parts by weight:

[0039] 80 parts of Sophora flavescens, 80 parts of Radix Angelicae Pubescentis, 80 parts of Herba Lycopodii, 80 parts of Radix Senecio, 5 parts of system stabilizer, 2000 parts of drinking water, 1 part of essence and 1 part of composite bacteria;

[0040] The system stabilizer is obtained by mixing polyhexamethylene guanidine, oligoxylose and liposome in a mass ratio of 10:3:1, and the liposome is lecithin liposome.

[0041] A production process of an antibacterial and antimicrobial Yi medicine comprises the following steps:

[0042] S1, collect the Chinese medicinal materials of Sophora flavescens, Herba scutellariae, Herba Ligustici Chuanxiong, and Herba Senecio, then wash the above Chinese medicinal materials with deionized water and dry them naturally, check their appearance and properties, and then weigh them. After verification, transfer them to the production workshop, slice, grind, crush, and pass through an 80-mesh sieve to obtain plant raw material powder;

[0043] S2, adding the plant raw material powder obtained in step S1 to deionized water at a mass volume ratio of 1 g: 5 mL, stirring evenly, soaking for 1 hour, then heating to boiling, and then cooling to room temperature to obtain a primary extraction system;

[0044] S3, mixing the primary extraction system, system stabilizer and composite bacteria obtained in step S1, and then fermenting and filtering to obtain a secondary extraction system;

[0045] The composite bacteria is obtained by mixing Lactobacillus plantarum and Bifidobacterium adolescentis in a mass ratio of 1:0.1; the inoculation amount of the composite bacteria is 3%, the fermentation temperature is set at 35° C., and the fermentation time is 48 hours;

[0046] S4. Transfer the secondary extraction system obtained in step S3 to a liquid preparation tank, add drinking water and essence, and then stir at room temperature until uniform. After testing the properties and pH value, filter with a 0.45um filter and then package to obtain an antibacterial and antimicrobial Yi medicine.

[0047] Example 2

[0048] A bacteriostatic and antibacterial Yi medicine formula, comprising the following raw materials in parts by weight:

[0049] 90 parts of Sophora flavescens, 90 parts of Radix Angelicae Pubescentis, 90 parts of Herba Lycopodii, 90 parts of Radix Senecio, 7 parts of system stabilizer, 2500 parts of drinking water, 3 parts of essence and 1.5 parts of composite bacteria;

[0050] The system stabilizer is obtained by mixing polyhexamethylene guanidine, oligoxylose and liposome in a mass ratio of 10:5:2, and the liposome is lecithin liposome.

[0051] A production process of an antibacterial and antimicrobial Yi medicine comprises the following steps:

[0052] S1, collect the Chinese medicinal materials of Sophora flavescens, Herba scutellariae, Herba Ligustici Chuanxiong, and Herba Senecio, then wash the above Chinese medicinal materials with deionized water and dry them naturally, check their appearance and properties, and then weigh them. After verification, transfer them to the production workshop, slice, grind, crush, and pass through an 80-mesh sieve to obtain plant raw material powder;

[0053] S2, adding the plant raw material powder obtained in step S1 to deionized water at a mass volume ratio of 1 g: 8 mL, stirring evenly, soaking for 2 hours, then heating to boiling, and then cooling to room temperature to obtain a primary extraction system;

[0054] S3, mixing the primary extraction system, system stabilizer and composite bacteria obtained in step S1, and then fermenting and filtering to obtain a secondary extraction system;

[0055] The composite bacteria is obtained by mixing Lactobacillus plantarum and Bifidobacterium adolescentis in a mass ratio of 1:0.2; the inoculation amount of the composite bacteria is 5%, the fermentation temperature is set at 38° C., and the fermentation time is 60 hours;

[0056] S4. Transfer the secondary extraction system obtained in step S3 to a liquid preparation tank, add drinking water and essence, and then stir at room temperature until uniform. After testing the properties and pH value, filter with a 0.45um filter and then package to obtain an antibacterial and antimicrobial Yi medicine.

[0057] Example 3

[0058] A bacteriostatic and antibacterial Yi medicine formula, comprising the following raw materials in parts by weight:

[0059] 100 parts of Sophora flavescens, 100 parts of Radix Angelicae Pubescentis, 100 parts of Herba Lycopodii, 100 parts of Radix Senecio, 8 parts of system stabilizer, 3000 parts of drinking water, 6 parts of essence and 2 parts of composite bacteria;

[0060] The system stabilizer is obtained by mixing polyhexamethylene guanidine, oligoxylose and liposome in a mass ratio of 10:7:3, and the liposome is ceramide liposome.

[0061] A production process of an antibacterial and antimicrobial Yi medicine comprises the following steps:

[0062] S1, collect the Chinese medicinal materials of Sophora flavescens, Herba scutellariae, Herba Ligustici Chuanxiong, and Herba Senecio, then wash the above Chinese medicinal materials with deionized water and dry them naturally, check their appearance and properties, and then weigh them. After verification, transfer them to the production workshop, slice, grind, crush, and pass through an 80-mesh sieve to obtain plant raw material powder;

[0063] S2, adding the plant raw material powder obtained in step S1 to deionized water at a mass volume ratio of 1 g: 10 mL, stirring evenly, soaking for 3 hours, then heating to boiling, and then cooling to room temperature to obtain a primary extraction system;

[0064] S3, mixing the primary extraction system, system stabilizer and composite bacteria obtained in step S1, and then fermenting and filtering to obtain a secondary extraction system;

[0065] The composite bacteria is obtained by mixing Lactobacillus plantarum and Bifidobacterium adolescentis in a mass ratio of 1:0.3; the inoculation amount of the composite bacteria is 7%, the fermentation temperature is set at 40° C., and the fermentation time is 72 hours;

[0066] S4. Transfer the secondary extraction system obtained in step S3 to a liquid preparation tank, add drinking water and essence, and then stir at room temperature until uniform. After testing the properties and pH value, filter with a 0.45um filter and then package to obtain an antibacterial and antimicrobial Yi medicine.

[0067] Comparative Example 1

[0068] The difference between this comparative example and Example 1 is that an antibacterial and antimicrobial Yi medicine formula comprises the following raw materials in parts by weight:

[0069] 80 parts of Sophora flavescens, 80 parts of Herba Polygoni Multiflori, 160 parts of Senecio radix, 5 parts of system stabilizer, 2000 parts of drinking water, 1 part of essence and 1 part of composite bacterial strain.

[0070] Comparative Example 2

[0071] The difference between this comparative example and Example 1 is that an antibacterial and antimicrobial Yi medicine formula comprises the following raw materials in parts by weight:

[0072] 80 parts of Sophora flavescens, 80 parts of Radix Polygoni Multiflori, 80 parts of Herba Plantaginis, 80 parts of Senecio grandis, 5 parts of system stabilizer, 2000 parts of drinking water, 1 part of essence and 1 part of composite bacterial strain.

[0073] Comparative Example 3

[0074] The difference between this comparative example and Example 1 is that an antibacterial and antimicrobial Yi medicine formula comprises the following raw materials in parts by weight:

[0075] 80 parts of Sophora flavescens, 80 parts of Radix Angelicae Pubescentis, 80 parts of Herba Lycopodii, 80 parts of Radix Senecio, 5 parts of system stabilizer, 2000 parts of drinking water, 1 part of essence and 1 part of composite bacteria;

[0076] The system stabilizer is obtained by mixing polyhexamethylene guanidine and xylooligosaccharide in a mass ratio of 10:4.

[0077] Comparative Example 4

[0078] The difference between this comparative example and Example 1 is that in this comparative example, Lactobacillus plantarum is used instead of the composite bacteria, and the inoculation amount is kept at 3%.

[0079] Comparative Example 5

[0080] The difference between this comparative example and Example 1 is that an antibacterial and antimicrobial Yi medicine formula comprises the following raw materials in parts by weight:

[0081] 80 parts of Sophora flavescens, 80 parts of Radix Angelicae Pubescentis, 80 parts of Herba Lycopodii, 80 parts of Radix Senecio, 5 parts of system stabilizer, 2000 parts of drinking water, 1 part of essence and 1 part of composite bacteria;

[0082] The system stabilizer is obtained by mixing polyhexamethylene guanidine, glucose and liposome in a mass ratio of 10:3:1.

[0083] Comparative Example 6

[0084] The difference between this comparative example and Example 1 is that an antibacterial and antimicrobial Yi medicine formula comprises the following raw materials in parts by weight:

[0085] 80-100 parts of Sophora flavescens, 80-100 parts of Radix schizonepetae, 80-100 parts of Herba Lycopodii, 80-100 parts of Radix Senecio, 5-8 parts of system stabilizer, 2000-3000 parts of drinking water, 1-6 parts of essence and 1-2 parts of composite bacteria;

[0086] The system stabilizer is obtained by mixing polyhexamethylene guanidine and liposomes in a mass ratio of 10:4;

[0087] Comparative Example 7

[0088] The difference between this comparative example and Example 1 is that the production process does not include a fermentation step, specifically:

[0089] A bacteriostatic and antibacterial Yi medicine formula, comprising the following raw materials in parts by weight:

[0090] 80 parts of Sophora flavescens, 80 parts of Radix Angelicae Pubescentis, 80 parts of Herba Lycopodii, 80 parts of Radix Senecio, 5 parts of system stabilizer, 2000 parts of drinking water and 1 part of essence;

[0091] The system stabilizer is obtained by mixing polyhexamethylene guanidine, oligoxylose and liposome in a mass ratio of 10:3:1.

[0092] S1, collect the Chinese medicinal materials of Sophora flavescens, Herba scutellariae, Herba Ligustici Chuanxiong, and Herba Senecio, then wash the above Chinese medicinal materials with deionized water and dry them naturally, check their appearance and properties, and then weigh them. After verification, transfer them to the production workshop, slice, grind, crush, and pass through an 80-mesh sieve to obtain plant raw material powder;

[0093] S2, adding the plant raw material powder obtained in step S1 to deionized water at a mass volume ratio of 1 g: 8 mL, stirring evenly, soaking for 2 hours, then heating to boiling, and then cooling to room temperature to obtain a primary extraction system;

[0094] S3, mixing the primary extraction system, the system stabilizer and the composite bacterial strain obtained in step S1, filtering and obtaining a secondary extraction system;

[0095] S4. Transfer the secondary extraction system obtained in step S3 to a liquid preparation tank, add drinking water and essence, and then stir at room temperature until uniform. After testing the properties and pH value, filter with a 0.45um filter and then package to obtain an antibacterial and antimicrobial Yi medicine.

[0096] Performance Testing

[0097] The antibacterial and antimicrobial Yi medicines prepared in Examples 1-3 and Comparative Examples 1-7 of the present application were tested for their antibacterial effects. Escherichia coli, Staphylococcus aureus and Candida albicans were taken as test strains to test the inhibitory effects of the samples prepared in different groups on different strains. 5 mL of sterilized culture medium was poured into a 25 mL sterilized culture dish for solidification. In the solidified culture medium, a sterile steel borer was used to make holes in the agar culture medium with a pore size of 6 mm. The microbial suspension was evenly applied to the surface of the solidified medium with a sterile swab, and 0.1 mL of the antibacterial and antimicrobial Yi medicine sample was added to each well with the help of a micropipette. The plate was incubated at 37 ° C for 24 hours to achieve antibacterial activity, and incubated at 25 ° C for 48 hours to obtain antifungal activity. Five readings were obtained for each sample and the average was taken. The specific test results are shown in Table 1 below:

[0098] Table 1

[0099]

[0100] As can be seen from the results in Table 1, the antibacterial and antimicrobial Yi medicine prepared in Example 2 showed good inhibitory effects on Escherichia coli, Staphylococcus aureus and Candida albicans. As can be seen from the results in Comparative Examples 1 and 2, the use of Sophora flavescens, Herba Sophorae Flavescentis, Herba Ligustici Chuanxiong and Herba Senecioides as components of the antibacterial liquid raw materials has the best antibacterial effect. As can be seen from the results in Comparative Examples 3-6, the use of liposomes and oligoxylose components and composite strains in the system stabilizer can promote the enrichment of antibacterial substances during the fermentation process and improve the antibacterial effect of the antibacterial and antimicrobial Yi medicine. As can be seen from the results in Comparative Example 7, the fermentation treatment of Chinese medicinal materials can improve the antibacterial effect of the antibacterial and antimicrobial Yi medicine.

[0101] The stability test of the antibacterial and antimicrobial Yi medicine prepared in Examples 1-3 and Comparative Examples 1-7 is now carried out. The antibacterial solution is stored in a dark environment at 40°C and 80RH% for 30 days, and then the pH value change of the initial system and the system after storage is detected, and the antibacterial effect change after storage is detected. Each sample is tested 5 times, and the average value is recorded. The test results are shown in Table 2 below.

[0102] Table 2

[0103]

[0104]

[0105] It can be seen from the results shown in Table 2 above that the system stability of the antibacterial and antimicrobial Yi medicines prepared in Examples 1-3 of the present application is significantly better than that of the antibacterial and antimicrobial Yi medicines prepared in Comparative Examples 1-7, that is, within the technical solution defined in the present application, the comprehensive performance of the antibacterial and antimicrobial Yi medicines prepared is excellent.

[0106] In the description of the specification, the description with reference to the terms "one embodiment", "example", "specific example", etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner.

[0107] The above contents are merely examples and explanations of the present invention. Those skilled in the art may make various modifications or additions to the specific embodiments described or replace them in a similar manner. As long as they do not deviate from the invention or exceed the scope defined by the claims, they shall all fall within the protection scope of the present invention.

Claims

1. An antibacterial and antimicrobial medicinal composition, characterized in that: It is composed of the following raw materials by weight: 80-100 parts of Sophora flavescens, 80-100 parts of Radix schizonepetae, 80-100 parts of Herba Lycopodii, 80-100 parts of Radix Senecio, 5-8 parts of system stabilizer, 2000-3000 parts of drinking water, 1-6 parts of essence and 1-2 parts of composite bacteria; The system stabilizer is obtained by mixing polyhexamethylene guanidine, xylooligosaccharide and liposome in a mass ratio of 10:(3-7):(1-3); The composite bacteria is obtained by mixing Lactobacillus plantarum and Bifidobacterium adolescentis in a mass ratio of 1:(0.1-0.3).

2. An antibacterial and antimicrobial medicinal composition according to claim 1, characterized in that: The liposome is at least one of phosphatidylcholine liposome, ceramide liposome and hyaluronic acid liposome.

3. The production process of an antibacterial and antimicrobial Yi medicine composition according to any one of claims 1 to 2, characterized in that: The following steps are involved: S1, collect Chinese medicinal materials of Sophora flavescens, Herba scutellariae, Herba Ligustici Chuanxiong, wash and dry them, check their appearance and properties, then weigh them, transfer them to the production workshop after verification, slice, grind, crush and sieve them to obtain plant raw material powder; S2, adding the plant raw material powder obtained in step S1 into deionized water, stirring evenly, soaking for 1-3 hours, then heating to boiling, and then cooling to room temperature to obtain a primary extraction system; S3, mixing the primary extraction system, system stabilizer and composite bacteria obtained in step S1, and then fermenting and filtering to obtain a secondary extraction system; S4. Add drinking water and essence to the secondary extraction system obtained in step S3, followed by stirring, filtering and packaging after properties and pH value testing to obtain an antibacterial and antimicrobial Yi medicine.

4. The production process of the antibacterial and antimicrobial Yi medicine composition according to claim 3, characterized in that: In step S3, the inoculation amount of the composite bacteria is 3-7%.

5. The production process of the antibacterial and antimicrobial Yi medicine composition according to claim 3, characterized in that: In step S3, during the fermentation process, the fermentation temperature is set at 35-40° C. and the fermentation time is set at 48-72 hours.

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