Shenxiong prescription for treating Alzheimer's disease and application

Abstract

The invention relates to the technical field of traditional Chinese medicines, and provides a Shenxiong formula for treating Alzheimer's disease and application, the Shenxiong formula is prepared from the following traditional Chinese medicines: 10-12 g of ginseng, 10-12 g of Ligusticum wallichii, 10-12 g of Polygonum multiflorum, 10-12 g of Poria cocos, 6-8 g of Chinese angelica, 6-8 g of Radix Astragali, 3-5 g of Radix Glehniae, 3-5 g of polygala tenuifolia, 3-5 g of white peony root, and 3-5 g of wolfberry. Through the comprehensive effects of tonifying the liver and kidney, promoting blood circulation to remove blood stasis, nourishing yin and blood, invigorating the spleen and replenishing qi and the like, the combination of the components achieves the purposes of overall conditioning, illness state stabilization, cognition slowing down, anxiety improvement and function decline slowing down aiming at the core pathogenesis of the liver-kidney yin deficiency type Alzheimer's disease.

Description

Technical Field

[0001] The present invention belongs to the field of traditional Chinese medicine preparations, and in particular relates to a Shenxiong prescription for treating Alzheimer's disease and an application thereof. Background Art

[0002] Alzheimer's disease (AD) is a progressive neurodegenerative disease with a complex pathogenesis involving multiple factors. In traditional Chinese medicine theory, AD can be classified as "dementia" and "forgetfulness", and is often associated with "liver and kidney yin deficiency". Liver and kidney yin deficiency type AD is mainly manifested by memory loss, decreased cognitive function, emotional instability, etc. Traditional Chinese medicine emphasizes the use of syndrome differentiation and treatment to harmonize yin and yang and nourish the liver and kidney to improve the patient's symptoms.

[0003] In the field of traditional Chinese medicine, Alzheimer's disease (AD) can usually be divided into the following syndromes according to its clinical manifestations and causes: Liver and kidney yin deficiency type: mainly manifested as memory loss, irritability, insomnia and dreaminess, etc., often accompanied by symptoms such as hot flashes and night sweats. Treatment focuses on nourishing yin and tonifying the kidney. Spleen and stomach weakness type: manifested as loss of appetite, indigestion, fatigue, memory loss, etc. Such patients usually need to strengthen the spleen and nourish the stomach. Phlegm and dampness blocking the collateral type: symptoms include confusion, slow thinking, unclear speech, accompanied by phlegm and chest tightness. The focus of treatment is to resolve phlegm and dredge the collaterals. Blood stasis type: manifested as memory loss, headache, dizziness, depression, etc., and there may be obvious mood swings. The treatment method focuses on promoting blood circulation and removing blood stasis. Heart and spleen deficiency type: symptoms include palpitations, insomnia, memory loss, loss of appetite, etc., often accompanied by pale complexion. Treatment emphasizes strengthening the spleen and nourishing the heart.

[0004] Currently, Shenqiong Fang is one of the classic prescriptions for treating Alzheimer's disease, mainly used to improve memory and cognitive function. The herbs such as ginseng and wolfberry in its formula have a tonic effect and can enhance the function of internal organs. However, existing research mainly focuses on the application of its basic formula, lacking specific adjustments and in-depth discussions for liver-kidney yin deficiency type Alzheimer's disease. This may limit the effectiveness of Shenqiong Fang when targeting specific symptoms and pathological mechanisms.

[0005] In order to improve the effectiveness of Shenqiong prescription in treating liver-kidney yin deficiency type Alzheimer's disease, it is possible to consider improving its composition. By introducing other Chinese medicinal materials with obvious yin-nourishing and kidney-tonifying effects, it is possible to not only enhance the overall efficacy of the prescription, but also produce more significant effects in improving cognitive behavior and anxiety-like behavior. Such improvements provide new treatment ideas for patients with liver-kidney yin deficiency type Alzheimer's disease, which helps to improve their quality of life and treatment satisfaction. Summary of the invention

[0006] In order to solve the above problems, the present invention first provides a Shenxiong prescription and application for treating Alzheimer's disease.

[0007] The invention provides a Shenqiong prescription for treating Alzheimer's disease, which is prepared from the following raw materials by weight: 10-12g of ginseng, 10-12g of Chuanxiong, 10-12g of Polygonum multiflorum, 10-12g of Poria, 6-8g of Angelica sinensis, 6-8g of Astragalus, 3-5g of Adenophora adenophora, 3-5g of Polygala tenuifolia, 3-5g of White Peony Root, and 3-5g of Lycium barbarum.

[0008] In some embodiments, the Shenqiong prescription is prepared from the following raw materials by weight: 12g ginseng, 10g Chuanxiong, 12g Polygonum multiflorum, 10g Poria, 6g Angelica, 8g Astragalus, 5g Northern Adenophora, 5g Polygala, 5g White Peony Root, and 5g Lycium barbarum.

[0009] In some embodiments, the Shenqiong prescription is prepared from the following raw materials by weight: 12g ginseng, 12g Chuanxiong, 10g Polygonum multiflorum, 10g Poria, 6g Angelica, 8g Astragalus, 5g Adenophora, 3g Polygala, 3g White Peony, and 5g Lycium barbarum.

[0010] In some embodiments, the Shenqiong prescription is prepared from the following raw materials by weight: 12g ginseng, 10g Chuanxiong, 12g Polygonum multiflorum, 10g Poria, 8g Angelica, 6g Astragalus, 5g Northern Adenophora, 5g Polygala, 3g White Peony, and 3g Lycium barbarum.

[0011] In some embodiments, the Shenqiong prescription is prepared from the following raw materials by weight: 10g ginseng, 12g Chuanxiong, 10g Polygonum multiflorum, 12g Poria, 6g Angelica sinensis, 6g Astragalus, 3g Northern Adenophora, 5g Polygala tenuifolia, 3g White Peony Root, and 3g Lycium barbarum.

[0012] In addition, the present invention also provides an application of Shenqiong prescription in preparing a medicine for treating liver-kidney yin deficiency type Alzheimer's disease.

[0013] The Shenqiongfang Chinese medicine composition of the present invention is used for Alzheimer's disease of liver and kidney yin deficiency type, and the formula comprises ginseng, Chuanxiong, Polygonum multiflorum, Poria, Angelica sinensis, Astragalus, Adenophora adenophora, Polygala tenuifolia, White Peony Root, and Lycium barbarum. The combination of these ingredients targets the core pathogenesis of Alzheimer's disease of liver and kidney yin deficiency type through the comprehensive effects of tonifying the liver and kidney, promoting blood circulation and removing blood stasis, nourishing yin and blood, and strengthening the spleen and replenishing qi, and achieves the purpose of overall conditioning, stabilizing the condition, slowing down cognition, improving anxiety, and slowing down functional decline.

[0014] Ginseng: Ginseng has the function of replenishing qi and nourishing yin, which can replenish qi and strengthen the spleen, and nourish the heart and blood. For liver and kidney yin deficiency type Alzheimer's disease, ginseng can enhance the overall physical fitness, improve blood supply to the brain, and improve cognitive and memory functions. It can enhance the patient's energy and disease resistance, help restore the normal function of the brain, and at the same time replenish qi and blood, improve blood and oxygen supply to the brain, and relieve fatigue and memory loss caused by qi deficiency.

[0015] Chuanxiong: Chuanxiong is an important medicinal material for promoting blood circulation and qi, which can promote blood circulation, improve brain microcirculation, and has a good conditioning effect on the symptoms of blood stasis caused by liver and kidney yin deficiency. It can promote qi and blood circulation, improve insufficient blood supply to the brain, help alleviate symptoms of cognitive impairment and slow thinking, and relieve the problem of poor blood flow to the brain caused by liver and kidney yin deficiency.

[0016] Polygonum multiflorum: Polygonum multiflorum has the functions of nourishing liver and kidney, nourishing blood and yin, strengthening kidney essence and delaying aging. It has a direct conditioning effect on memory loss and slow thinking caused by liver and kidney yin deficiency. It nourishes kidney essence, nourishes liver yin, strengthens the supply of brain marrow, relieves the degeneration of the nervous system, and improves the cognitive function and memory of patients with Alzheimer's disease.

[0017] Poria: Poria has the effects of strengthening the spleen and eliminating dampness, calming the mind and tranquilizing the nerves. It helps to improve the deficiency of qi and blood biochemical production caused by spleen deficiency, thereby indirectly nourishing the brain. At the same time, it can calm the mind and tranquilize the nerves, helping to relieve the anxiety and emotional instability of patients with Alzheimer's disease. It improves spleen deficiency, promotes qi and blood biochemical production, and has a sedative and tranquilizing effect, reducing the patient's anxiety, improving sleep quality, and helping to restore cognitive function.

[0018] Angelica: Angelica has the function of nourishing blood and activating blood circulation, regulating qi and blood, and nourishing the brain. For patients with liver and kidney yin deficiency type Alzheimer's disease, Angelica can nourish the heart blood, improve brain blood circulation, and alleviate the symptoms of insufficient blood supply to the brain. It nourishes blood and activates blood circulation, nourishes the brain marrow, improves cognitive function, and relieves memory loss and inattention caused by blood deficiency.

[0019] Astragalus: Astragalus has the functions of replenishing Qi and raising Yang, strengthening the body's defense system and strengthening the exterior. It can enhance the body's immune function and improve the overall Qi and blood circulation. For patients with Alzheimer's disease, Astragalus can increase the blood and oxygen supply to the brain. It can strengthen the body's constitution, improve immunity, replenish Qi and generate blood, improve blood supply to the brain, and help slow down the cognitive decline symptoms of Alzheimer's disease.

[0020] Beisha: Beisha ginseng has the function of nourishing yin and moistening the lungs, nourishing yin fluid and improving the symptoms of yin deficiency in the body. For liver and kidney yin deficiency type Alzheimer's disease, Beisha ginseng helps restore the balance of yin fluid and alleviate the decline of brain function caused by yin deficiency. It nourishes liver and kidney yin fluid, improves dizziness, tinnitus, insomnia and cognitive decline caused by yin deficiency, and helps improve the overall health of patients.

[0021] Polygala: Polygala is a well-known drug for calming the mind and improving intelligence. It can calm the mind, open the mind and improve intelligence. It has a direct effect on improving cognitive impairment, anxiety and memory loss in Alzheimer's disease with liver and kidney yin deficiency. It calms the mind and improves intelligence, opens the mind and wakes up the brain, improves cognitive function and mood swings in Alzheimer's patients, and alleviates insomnia and anxiety symptoms caused by liver and kidney yin deficiency.

[0022] White peony root: White peony root has the effects of nourishing blood, restraining yin, calming the liver and relieving pain. It can relieve the symptoms of hyperactivity of liver yang caused by liver and kidney yin deficiency and help regulate the liver's drainage function. For patients with liver and kidney yin deficiency, white peony root can nourish blood and nourish yin, and balance liver function. It nourishes blood and restrains yin, harmonizes liver function, relieves dizziness, insomnia and emotional instability caused by yin deficiency, and helps stabilize the patient's mental state.

[0023] Lycium barbarum: Lycium barbarum nourishes the liver and kidneys, improves eyesight and calms the mind. It is rich in vitamins and antioxidants, which can enhance the function of the liver and kidneys and improve the yin deficiency constitution. At the same time, it can protect nerve cells and alleviate cognitive decline. It nourishes the liver and kidneys, enhances the stability of the nervous system, protects brain cells, slows down the progression of Alzheimer's disease, and improves the patient's memory and learning ability.

[0024] Compared with the traditional Chinese medicines recorded in the prior art, the combination of various medicinal materials in the prescription of the present invention realizes the treatment principle of "holistic conditioning" in traditional Chinese medicine:

[0025] Nourishes the liver and kidneys, nourishes the essence and fills the marrow: Through the nourishing effects of Polygonum multiflorum and ginseng in the main medicine and Adenophora adenophora and Lycium barbarum in the auxiliary medicine, the liver and kidneys are nourished and the kidney essence is nourished. The kidneys are responsible for bone and marrow production, and the brain is the sea of ​​marrow. By nourishing the kidney essence, the brain marrow can be strengthened and cognitive and memory functions can be improved.

[0026] Activate blood circulation and dissipate stasis, improve blood circulation: Chuanxiong in the main drug and Angelica in the auxiliary drug can activate blood circulation and dissipate stasis, promote blood circulation, thereby improving brain microcirculation, increasing blood and oxygen supply to the brain, and alleviating the problem of insufficient blood supply to the brain. Nourish yin and blood, balance yin and yang: The adjuvant drug Adenophora radix and the auxiliary drug Paeonia lactiflora have the effect of nourishing yin and blood, help restore the balance of yin fluid in the body, alleviate the imbalance of yin and yang caused by liver and kidney yin deficiency, stabilize emotions, and improve insomnia, anxiety and mood swings.

[0027] Strengthen the spleen and replenish qi, calm the mind and stabilize the spirit: Ginseng and Poria cocos have the effect of replenishing qi and strengthening the spleen, improving the insufficient biochemical state of qi and blood caused by qi deficiency, helping to nourish blood and calm the mind, and assisting in improving the decline in cognitive function and anxiety caused by liver and kidney yin deficiency.

[0028] Comprehensive regulation to protect neurons: Polygala and Lycium barbarum in the prescription can calm the mind, improve intelligence, nourish the liver and kidneys, and protect nerve cells. By regulating the nervous system and immune system, it delays the neurodegenerative process of Alzheimer's disease. DETAILED DESCRIPTION

[0029] In order to make the technical problems to be solved, technical solutions and advantages of the present invention more clear, they are described in detail below in conjunction with specific embodiments.

[0030] Example 1

[0031] A Shenqiong prescription 1 for treating Alzheimer's disease is prepared from the following raw materials by weight:

[0032] Main medicine: ginseng 12g, Chuanxiong 10g, Polygonum multiflorum 12g, Poria 10g;

[0033] Assistant medicine: Angelica 6g, Astragalus 8g;

[0034] Adjuvants: Radix Adenophorae 5g, Radix Polygalae 5g;

[0035] Auxiliary drugs: white peony root 5g, wolfberry 5g.

[0036] Example 2

[0037] A Shenqiong prescription 2 for treating Alzheimer's disease is prepared from the following raw materials by weight:

[0038] Main medicine: ginseng 12g, Chuanxiong 12g, Polygonum multiflorum 10g, Poria 10g;

[0039] Assistant medicine: Angelica 6g, Astragalus 8g;

[0040] Adjuvants: Radix Adenophorae 5g, Radix Polygalae 3g;

[0041] Auxiliary drugs: white peony root 3g, wolfberry 5g.

[0042] Example 3

[0043] A Shenqiong prescription 3 for treating Alzheimer's disease is prepared from the following raw materials by weight:

[0044] Main medicine: ginseng 12g, Chuanxiong 10g, Polygonum multiflorum 12g, Poria 10g;

[0045] Assistant medicine: Angelica 8g, Astragalus 6g;

[0046] Adjuvants: Radix Adenophorae 5g, Radix Polygalae 5g;

[0047] Auxiliary drugs: white peony root 3g, wolfberry 3g.

[0048] Example 4

[0049] A Shenqiong prescription 4 for treating Alzheimer's disease is prepared from the following raw materials by weight:

[0050] Main medicine: ginseng 10g, Chuanxiong 12g, Polygonum multiflorum 10g, Poria 12g;

[0051] Assistant medicine: Angelica 6g, Astragalus 6g;

[0052] Adjuvants: Radix Adenophorae 3g, Radix Polygalae 5g;

[0053] Auxiliary drugs: white peony root 3g, wolfberry 3g.

[0054] Example 5

[0055] A preparation method of Shenqiong prescription 1-4 for treating Alzheimer's disease is as follows:

[0056] Step 1: Pretreatment of medicinal materials

[0057] Raw material preparation: Weigh the raw materials recorded in Examples 1-4, confirm that the quality meets the standards, and remove impurities such as dust, sand, etc.

[0058] Cleaning: Rinse the medicinal materials involved in Examples 1-4 quickly with clean water to remove surface attachments, and drain as much water as possible after cleaning.

[0059] Drying treatment: Place the cleaned medicinal materials in a drying oven at about 60°C to ensure that the moisture content is less than 10% to facilitate subsequent crushing and extraction.

[0060] Step 2: Crushing

[0061] Coarse powder grinding: The dried medicinal materials are coarsely ground to obtain coarse granular medicinal material powder.

[0062] Fine powder grinding: The coarse powder medicinal materials are further processed by an ultra-fine grinder and crushed into a fine powder state, so that the powder particle size is between 80-100 mesh, in order to increase the surface area of ​​the medicinal materials and facilitate the subsequent extraction of effective ingredients.

[0063] Step 3: Extracting active ingredients

[0064] Selection of extraction solvent: According to the medicinal properties of the medicinal materials, 70% ethanol was selected as the extraction solvent.

[0065] Extraction method: Place the crushed medicinal materials in an extraction tank, add 70% ethanol, and control the liquid-to-solid ratio at 10:1 (10 times the volume of ethanol).

[0066] Heat to 70°C and maintain extraction for 1.5 hours to perform the first extraction.

[0067] The first extract was obtained by filtration, and 70% ethanol was added to the residue, which was heated to 70°C again and extracted for 1 hour for the second extraction.

[0068] The two extracts were combined, allowed to settle for 12 hours, and further filtered to remove impurities to obtain a clarified extract.

[0069] Step 4: Concentration and drying

[0070] Concentration: The extract is placed in a rotary evaporator and concentrated under reduced pressure (50-60° C.) to a thick paste, with the residual solvent controlled below 5%.

[0071] Spray drying: The concentrated thick paste is dried using a spray dryer, and the temperature is controlled at 60-80° C. to obtain a dry fine powder extract of Shenqiong Prescription 1-4 Chinese medicine.

[0072] Example 6 Experiment on the improvement of cognitive behavior and anxiety-like behavior of Alzheimer's disease mice with liver and kidney yin deficiency syndrome by using Shenqiong prescription 1-4

[0073] Healthy C57BL / 6 mice, 6-8 weeks old, of either sex, weighing 18-22 g, were injected with chemical reagents aluminum chloride and D-galactose combined with a high-fat diet to induce the formation of a liver-kidney yin deficiency type Alzheimer's disease model in mice, and the modeling lasted for 8 weeks.

[0074] Induction of Alzheimer's disease: D-galactose (120 mg / kg) was injected intraperitoneally once a day for 8 weeks to simulate the pathological process of Alzheimer's disease. D-galactose can cause oxidative stress and neurotoxicity, causing mice to show memory and cognitive impairment.

[0075] The kidney yang deficiency model was established based on D-galactose injection, and mice received the following interventions to induce kidney yang deficiency:

[0076] Hydrocortisone (10 mg / kg) was injected subcutaneously once a day for 4 weeks. Hydrocortisone can inhibit adrenal cortical function and lead to symptoms related to kidney yang deficiency. At the same time, the model mice were fed with a high-fat diet, which aggravated the symptoms of kidney yang deficiency.

[0077] The Alzheimer's disease model mice with liver-kidney yin deficiency syndrome showed Alzheimer's disease-like pathological characteristics and cognitive dysfunction, accompanied by symptoms of liver-kidney yin deficiency diagnosed by traditional Chinese medicine.

[0078] The mice were randomly divided into the following 5 groups, with 12 mice in each group:

[0079] Normal control group: normal mice were given normal saline without any treatment;

[0080] Model group: Alzheimer's disease model mice with liver-kidney yin deficiency were treated with normal saline without drug intervention;

[0081] Shenqiong Prescription Group 1: Alzheimer's disease model mice with liver-kidney yin deficiency were given Prescription No. 1 at a dose of 1000 mg / kg once a day for 8 consecutive weeks (once a day) by gavage;

[0082] Shenqiong Prescription 2 group: Alzheimer's disease model mice with liver-kidney yin deficiency were given prescription No. 2 at a dose of 1000 mg / kg once a day for 8 consecutive weeks (once a day) by gavage;

[0083] Shenqiong Prescription 3 group: Alzheimer's disease model mice with liver-kidney yin deficiency were given prescription No. 3 at a dose of 1000 mg / kg once a day for 8 consecutive weeks (once a day) by gavage;

[0084] Shenqiong Prescription 4 group: Alzheimer's disease model mice with liver-kidney yin deficiency were given prescription No. 4 at a dose of 1000 mg / kg once a day for 8 consecutive weeks (once a day) by gavage;

[0085] Positive control group: Alzheimer's disease model mice with liver-kidney yin deficiency were given donepezil once a day at a dose of 2 mg / kg for 8 consecutive weeks (once a day) by gavage;

[0086] Morris water maze test evaluates the spatial learning and memory ability of mice:

[0087] Training phase: Water maze training was performed for 4 consecutive days, and the latency of mice to find the platform was recorded every day.

[0088] Testing phase: On the 5th day, the platform was removed and the time the mice stayed in the quadrant where the original platform was located and the number of times they crossed were recorded.

[0089] Observation indicators: escape latency, residence time in the target quadrant, number of crossing the original platform area, and cognitive index.

[0090] Table 1 Changes in escape latency in mice with liver and kidney yin deficiency diagnosed by the prescription (x±s, n=12)

[0091]

[0092]

[0093] Note: Compared with the normal control group, a P<0.05, b P<0.01; compared with the model group, c P<0.05, d P<0.01.

[0094] The results in Table 1 showed that after the 5th day, compared with the normal control group, the escape latency of the mice in the model group was significantly prolonged (P < 0.05); compared with the model group, the escape latency of the mice in the Shenqiong Prescription 1-2 group was significantly shortened (P < 0.05); and the escape latency of the mice in the Shenqiong Prescription 3-4 group was significantly shortened (P < 0.01).

[0095] Table 2 Effect of the prescription on the target quadrant swimming percentage and platform crossing times of Alzheimer's disease model mice with liver and kidney yin deficiency syndrome (x±s, n=12)

[0096]

[0097] Note: Compared with the normal control group, a P<0.05, b P<0.01; compared with the model group,c P<0.05, d P<0.01.

[0098] The results in Table 1 show that in the space exploration experiment, compared with the normal control group, the number of times the mice in the model group crossed the platform (P < 0.01) and the percentage of the target quadrant swimming distance were significantly reduced (P < 0.05); compared with the model group, the number of times the mice in the Shenqiong prescription 1-4 groups and the positive control group crossed the platform and the percentage of the target quadrant swimming distance were significantly increased (P < 0.05, 0.01).

[0099] Table 3 Effect of prescription on cognitive index of liver-kidney yin deficiency Alzheimer's disease model mice (x±s, n=12)

[0100] Group Cognitive index / (%) Normal control group 72±12 Model Group <![CDATA[32±14 b ]]> Shenqiong prescription 1 group <![CDATA[56±10 c ]]> Shenqiong Prescription Group 2 <![CDATA[63±15 c ]]> Shenqiong Prescription 3 Group <![CDATA[57±13 d ]]> 4 groups of Shenqiong prescription <![CDATA[67±14 d ]]> Positive control group <![CDATA[53±11 c ]]>

[0101] Note: Compared with the normal control group, a P<0.05, b P<0.01; compared with the model group, c P<0.05, d P<0.01.

[0102] The results in Table 3 show that in the new object recognition experiment, compared with the normal control group, the cognitive index of mice in the model group was significantly reduced (P < 0.01); compared with the model group, the cognitive index of mice in the Shenqiong prescription 1-4 groups and the positive control group was significantly increased (P < 0.05, 0.01).

[0103] The open field test was used to test the mice's locomotor activity and anxiety level:

[0104] The mice were placed in the center of the open field test apparatus, and their movement trajectory, total movement distance, number of times they entered the center area, and the duration of their stay were observed within 10 minutes.

[0105] Observation indicators: central area movement distance, time percentage and number of times entering the central area.

[0106] Table 4 Changes in the central area movement distance, time percentage and number of times entering the central area in the Alzheimer's disease model mice with liver and kidney yin deficiency syndrome tested by the prescription (x±s, n=12)

[0107]

[0108]

[0109] Note: Compared with the normal control group, a P<0.05, b P<0.01; compared with the model group, c P<0.05, dP<0.01.

[0110] The results in Table 4 showed that in the open field test, compared with the normal control group, the percentage of central area movement distance, the percentage of central area movement time and the number of times entering the central area of ​​the mice in the model group were significantly reduced (P < 0.05, 0.01); compared with the model group, the percentage of central area movement distance, the percentage of central area movement time and the number of times entering the central area of ​​the mice in the Shenqiong Prescription 1-4 groups and the positive control group were significantly increased (P < 0.05, 0.01).

[0111] The above is a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A Shenxiong prescription for treating Alzheimer's disease, characterized in that: The product is prepared from the following raw materials by weight: 10-12g ginseng, 10-12g Chuanxiong, 10-12g Polygonum multiflorum, 10-12g Poria, 6-8g Angelica sinensis, 6-8g Astragalus membranaceus, 3-5g Adenophora adenophora, 3-5g Polygala tenuifolia, 3-5g White Peony Root, and 3-5g Lycium barbarum.

2. The ginseng recipe according to claim 1, characterized in that: The Shenqiong prescription is prepared from the following raw materials by weight: 12g ginseng, 10g Chuanxiong, 12g Polygonum multiflorum, 10g Poria, 6g Angelica sinensis, 8g Astragalus, 5g Adenophora adenophora, 5g Polygala tenuifolia, 5g White Peony Root, and 5g Lycium barbarum.

3. The ginseng recipe according to claim 1, characterized in that: The Shenqiong prescription is prepared from the following raw materials by weight: 12g ginseng, 12g Chuanxiong, 10g Polygonum multiflorum, 10g Poria, 6g Angelica sinensis, 8g Astragalus, 5g Adenophora adenophora, 3g Polygala tenuifolia, 3g White Peony Root, and 5g Lycium barbarum.

4. The ginseng recipe according to claim 1, characterized in that: The Shenqiong prescription is prepared from the following raw materials by weight: 12g ginseng, 10g Chuanxiong, 12g Polygonum multiflorum, 10g Poria, 8g Angelica sinensis, 6g Astragalus, 5g Adenophora adenophora, 5g Polygala tenuifolia, 3g White Peony Root, and 3g Lycium barbarum.

5. The ginseng recipe according to claim 1, characterized in that: The Shenqiong prescription is prepared from the following raw materials by weight: 10g ginseng, 12g Chuanxiong, 10g Polygonum multiflorum, 12g Poria, 6g Angelica sinensis, 6g Astragalus, 3g Adenophora adenophora, 5g Polygala tenuifolia, 3g White Peony Root, and 3g Lycium barbarum.

6. Use of the Shenqiong prescription according to any one of claims 1 to 5 in the preparation of a medicament for treating Alzheimer's disease of liver-kidney yin deficiency type.

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