Personal care compositions for sensitive skin and methods of use thereof

Abstract

Provided herein are personal care compositions for reducing signs of aging of sensitive skin without producing irritating effects associated with retinol. Such personal care compositions include nicotinamide, a Leontopodium alpinum extract, an Oryza sativa distillers' grain extract, a panthenol, and a soybean derived glycopeptide. The invention also relates to a method for preparing such personal care compositions. The personal care compositions may include nicotinamide, a Leontopodium alpinum extract, an Oryza sativa distillers' grain extract, a panthenol, and a soybean derived glycopeptide. Use of such compositions also modulates some biochemical indicators associated with premature aging of the skin due to contamination.

Description

[0001] Cross-references

[0002] This application claims the benefit of U.S. Provisional Patent Application No. 63 / 325,960, filed on March 31, 2022, which is incorporated by reference in its entirety. Technical Field

[0003] The present disclosure relates generally to the field of skin care. Contains personal care compositions that protect sensitive skin from environmental challenges (e.g., pollution), restore healthy balance (e.g., healthy balance of skin pH, skin moisture, etc.), and improve signs of aging. The present disclosure also provides methods for treating sensitive skin of a subject using the personal care compositions described herein. Background Art

[0004] The skin is the first line of defense against environmental challenges, including artificial blue light, particulate matter and ultraviolet (UV) light, which over time can damage the skin and accelerate skin aging.

[0005] Sensitive skin is described as an altered response to environmental factors, resulting in adverse sensations such as stinging, warmth, burning, itching, tightness and erythema, affecting all parts of the body, especially the face. Sensitive skin exhibits inflammation, especially altered skin barrier, epidermal thickening with hyperplasia, collagen disturbance, and reduced vascular network, making it more susceptible to surface and underlying damage, and neurosensitivity, causing sensitive skin to age faster than normal skin.

[0006] Anti-aging lotions often contain retinoids, which can stimulate the synthesis of type I collagen and reduce wrinkles to maintain healthy and youthful skin, but retinoids may also irritate sensitive skin and make it more sensitive.

[0007] There is an unmet need for compositions that slow or reduce the signs of aging in sensitive skin. Summary of the invention

[0008] In one aspect, which may be combined with any other aspect or embodiment, the present disclosure relates to a personal care composition comprising, by weight of the total composition:

[0009] (a) 0.1%-10% niacinamide,

[0010] (b) 0.0001% to 10% of Edelweiss (Leontopodium alpinum) extract,

[0011] (c) 0.001% to 10% of rice (Oryza sativa) sake lees concentrate,

[0012] (d) 0.1% to 10% panthenol, and

[0013] (e) 0.001%-5% soybean-derived glycopeptide.

[0014] In some embodiments, the personal care composition comprises, by weight of the total composition, 0.1%-4% niacinamide, 0.001%-4% Edelweiss (alpine edelweiss), 0.001%-2% rice (rice) sake lees concentrate, 0.1%-3% panthenol, and 0.002%-4% soy-derived glycopeptide.

[0015] In some embodiments, the personal care composition does not include any retinoid or retinoid derivative.

[0016] In some embodiments, the personal care composition further comprises at least one of: water, adenosine, a humectant, a photoprotective filter, an antioxidant, a preservative, a gelling agent, a solvent, a pH balancing agent, and a surfactant.

[0017] In some embodiments, the humectant includes at least one of Buddleja davidii extract, Thymus vulgaris extract, caprylyl glycol, glycerin, 1,2-hexanediol, butylene glycol, or any combination thereof.

[0018] In some embodiments, the personal care composition further comprises, by weight of the total composition, 0.01%-2% adenosine, 0.0001%-3% Buddleja macrophylla extract, and 0.0001%-3% thyme extract.

[0019] In some embodiments, the photoprotective filter comprises at least one of zinc oxide, titanium dioxide, and iron oxide.

[0020] In some embodiments, the personal care composition is a cream, lotion, gel, mask, serum, or spray.

[0021] On the other hand, which can be combined with any other aspect or embodiment, the present disclosure relates to a method for treating sensitive skin in a subject, the method comprising applying to the subject a personal care composition comprising: niacinamide, Edelweiss (alpine edelweiss) extract, rice (rice) sake lees concentrate, panthenol and soy-derived glycopeptide.

[0022] In some embodiments, said sensitive skin exhibits at least one unpleasant sensation prior to said treatment, said at least one unpleasant sensation selected from the group consisting of stinging, warmth, burning, itching, tightness, and erythema.

[0023] In some embodiments, said application of said personal care composition results in a reduction in wrinkles or a delay in the onset of wrinkles. In some embodiments, said application of said personal care composition results in a reduction in the signs of aging by at least 3%, 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 50%, 60%, 70%, 80%, 90%, 95%, 99% or more compared to application of the same composition without niacinamide, edelweiss (alpine edelweiss) extract, rice (rice) sake lees concentrate, panthenol, and soy-derived glycopeptides.

[0024] In some embodiments, the personal care composition does not include any retinoid or retinoid derivative.

[0025] In some embodiments, the personal care composition comprises, by weight of the total composition:

[0026] (a) 0.1%-10% niacinamide,

[0027] (b) 0.0001% to 10% of Edelweiss (alpine edelweiss) extract,

[0028] (c) 0.001% to 10% of rice (paddy) sake lees concentrate,

[0029] (d) 0.1% to 10% panthenol, and

[0030] (e) 0.001%-5% soybean-derived glycopeptide.

[0031] In some embodiments, the personal care composition comprises, by weight of the total composition, 0.1%-4% niacinamide, 0.001%-4% Edelweiss (alpine edelweiss), 0.001%-2% rice (rice) sake lees concentrate, 0.1%-3% panthenol, and 0.002%-4% soy-derived glycopeptide.

[0032] In some embodiments, the personal care composition does not include any retinoid or retinoid derivative.

[0033] In some embodiments, the personal care composition further comprises at least one of: water, adenosine, a humectant, a photoprotective filter, an antioxidant, a preservative, a gelling agent, a solvent, a pH balancing agent, and a surfactant.

[0034] In some embodiments, the moisturizer includes at least one of: Buddleja macrophylla extract, thyme extract, caprylyl glycol, glycerin, 1,2-hexanediol, butylene glycol, or any combination thereof.

[0035] In some embodiments, the personal care composition further comprises, by weight of the total composition, 0.01%-2% adenosine, 0.0001%-3% Buddleja macrophylla extract, and 0.0001%-3% thyme extract.

[0036] In some embodiments, the photoprotective filter comprises at least one of zinc oxide, titanium dioxide, and iron oxide.

[0037] In some embodiments, the personal care composition is a cream, lotion, gel, mask, serum, or spray.

[0038] In another aspect, which may be combined with any other aspect or embodiment, the present disclosure relates to a personal care composition comprising, by weight of the total composition:

[0039] (a) 0.1%-10% niacinamide,

[0040] (b) 0.0001% to 10% of Edelweiss (alpine edelweiss) extract,

[0041] (c) 0.001% to 10% of rice (paddy rice) sake lees concentrate, and

[0042] (d) 0.1%-10% panthenol.

[0043] In some embodiments, the personal care composition further comprises: (e) 0.001%-5% of soy-derived glycopeptide.

[0044] In some embodiments, the personal care composition comprises, by weight of the total composition, 0.1%-4% niacinamide, 0.001%-4% edelweiss (alpine edelweiss), 0.001%-2% rice (rice) sake lees concentrate, 0.1%-3% panthenol, and 0.002%-4% soy-derived glycopeptide. In some embodiments, the personal care composition does not include any retinoid or retinoid derivative.

[0045] In some embodiments, the personal care composition further comprises at least one of: water, adenosine, a humectant, a photoprotective filter, an antioxidant, a preservative, a gelling agent, a solvent, a pH balancing agent, and a surfactant.

[0046] In some embodiments, the moisturizer includes at least one of: Buddleja macrophylla extract, thyme extract, caprylyl glycol, glycerin, 1,2-hexanediol, butylene glycol, or any combination thereof.

[0047] In some embodiments, the personal care composition further comprises, by weight of the total composition, 0.01%-2% adenosine, 0.0001%-3% Buddleja macrophylla extract, and 0.0001%-3% thyme extract.

[0048] In some embodiments, the photoprotective filter comprises at least one of zinc oxide, titanium dioxide, and iron oxide.

[0049] In some embodiments, the personal care composition is a cream, lotion, gel, mask, serum, or spray.

[0050] In another aspect, which may be combined with any other aspect or embodiment, the present disclosure relates to a method for reducing the appearance of wrinkles in a subject with sensitive skin, the method comprising applying to the subject a personal care composition comprising: niacinamide, Edelweiss (alpine edelweiss) extract, Oryza sativa (rice) sake lees concentrate, panthenol, and soy-derived glycopeptide.

[0051] In some embodiments, the method further comprises exposing the subject's skin to pollution after treatment with a composition disclosed herein.

[0052] In some embodiments, the subject's skin has been exposed to pollution.

[0053] In some embodiments, the pollution is air pollution. In some embodiments, the air pollution has an air quality index (AQI) greater than 100, 150, 200, 250, or 300. In some embodiments, the pollution is water pollution.

[0054] In some embodiments, the personal care composition does not include any retinoid or retinoid derivative.

[0055] In some embodiments, the personal care composition comprises, by weight of the total composition:

[0056] (a) 0.1% to 10% by weight of nicotinamide,

[0057] (b) 0.0001% to 10% by weight of an extract of Edelweiss (alpine edelweiss),

[0058] (c) 0.001% to 10% by weight of rice (paddy rice) sake lees concentrate,

[0059] (d) 0.1% to 10% by weight of panthenol, and

[0060] (e) 0.001 wt% to 5 wt% of soybean-derived glycopeptide.

[0061] In some embodiments, said application of said personal care composition results in a reduction in wrinkles or a delay in the onset of wrinkles. In some embodiments, said application of said personal care composition results in a reduction in signs of aging by at least 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 50%, 60%, 70%, 80%, 90%, 95%, 99% or more compared to application of the same composition without niacinamide, edelweiss (alpine edelweiss) extract, rice (rice) sake lees concentrate, panthenol, and soy-derived glycopeptides.

[0062] In some embodiments, the subject includes a human. In some embodiments, the subject has been exposed to pollution. In some embodiments, the subject has been exposed to air pollution. In some embodiments, the subject has been exposed to air pollution with an air quality index (AQI) higher than 100. In some embodiments, the subject is exposed to air pollution with an air quality index (AQI) higher than 150. In some embodiments, the subject is exposed to air pollution with an air quality index (AQI) higher than 200. In some embodiments, the subject is exposed to air pollution with an air quality index (AQI) higher than 250. In some embodiments, the subject is exposed to air pollution with an air quality index (AQI) higher than 300.

[0063] In some embodiments, the personal care composition comprises, by weight of the total composition, 0.1%-4% niacinamide, 0.001%-4% Edelweiss (alpine edelweiss), 0.001%-2% rice (rice) sake lees concentrate, 0.1%-3% panthenol, and 0.002%-4% soy-derived glycopeptide.

[0064] In some embodiments, the personal care composition does not include any retinoid or retinoid derivative.

[0065] In some embodiments, the personal care composition further comprises at least one of: water, adenosine, a humectant, a photoprotective filter, an antioxidant, a preservative, a gelling agent, a solvent, a pH balancing agent, and a surfactant.

[0066] In some embodiments, the moisturizer includes at least one of: Buddleja macrophylla extract, thyme extract, caprylyl glycol, glycerin, 1,2-hexanediol, butylene glycol, or any combination thereof.

[0067] In some embodiments, the personal care composition further comprises, by weight of the total composition, 0.01%-2% adenosine, 0.0001%-3% Buddleja macrophylla extract, and 0.0001%-3% thyme extract.

[0068] In some embodiments, the photoprotective filter comprises at least one of zinc oxide, titanium dioxide, and iron oxide.

[0069] In some embodiments, the personal care composition is a cream, lotion, gel, mask, serum, or spray.

[0070] In some embodiments, the personal care composition is applied topically. In some embodiments, the personal care composition is applied every hour, every 2 hours, every 3 hours, every 6 hours, every 12 hours, or every day, every other day, or every three days. In some embodiments, the personal care composition is applied for at least 10 days, 11 days, 12 days, 13 days, 14 days, 15 days, 16 days, 17 days, 18 days, 19 days, or 20 days before a decrease in signs of aging of sensitive skin (reduction in wrinkles, e.g., decrease, increase in the crow's feet area) or a decrease in at least one adverse sensation of sensitive skin (e.g., stinging, heating, burning, itching, tightness, and erythema) is observed.

[0071] In another aspect, which may be combined with any other aspect or embodiment, the present disclosure relates to a method of reducing pollution-induced NADPH oxidase in mitochondria by applying to human skin a composition comprising niacinamide, alpine edelweiss extract, rice (orchid) sake lees concentrate, and panthenol.

[0072] In some embodiments, the composition further comprises at least one of: water, adenosine, a humectant, a photoprotective filter, an antioxidant, a preservative, a gelling agent, a solvent, a pH balancing agent, and a surfactant.

[0073] In some embodiments, the moisturizer includes at least one of: Buddleja macrophylla extract, thyme extract, caprylyl glycol, glycerin, 1,2-hexanediol, butylene glycol, or any combination thereof.

[0074] In some embodiments, the personal care composition further comprises, by weight of the total composition, 0.01%-2% adenosine, 0.0001%-3% Buddleja macrophylla extract, and 0.0001%-3% thyme extract.

[0075] In some embodiments, the photoprotective filter comprises at least one of zinc oxide, titanium dioxide, and iron oxide.

[0076] In another aspect, which may be combined with any other aspect or embodiment, the present disclosure relates to a method of reducing pollution-induced fragmentation of mitochondria by applying to human skin a composition comprising niacinamide, edelweiss extract, rice (orchidaceae) sake lees concentrate, and panthenol.

[0077] In some embodiments, the composition further comprises at least one of: water, adenosine, a humectant, a photoprotective filter, an antioxidant, a preservative, a gelling agent, a solvent, a pH balancing agent, and a surfactant.

[0078] In some embodiments, the moisturizer includes at least one of: Buddleja macrophylla extract, thyme extract, caprylyl glycol, glycerin, 1,2-hexanediol, butylene glycol, or any combination thereof.

[0079] In some embodiments, the personal care composition further comprises, by weight of the total composition, 0.01%-2% adenosine, 0.0001%-3% Buddleja macrophylla extract, and 0.0001%-3% thyme extract.

[0080] In some embodiments, the photoprotective filter comprises at least one of zinc oxide, titanium dioxide, and iron oxide.

[0081] In some embodiments, the composition further comprises at least one of: water, adenosine, a humectant, a photoprotective filter, an antioxidant, a preservative, a gelling agent, a solvent, a pH balancing agent, and a surfactant.

[0082] In some embodiments, the moisturizer includes at least one of: Buddleja macrophylla extract, thyme extract, caprylyl glycol, glycerin, 1,2-hexanediol, butylene glycol, or any combination thereof.

[0083] In some embodiments, the photoprotective filter comprises at least one of zinc oxide, titanium dioxide, and iron oxide.

[0084] In another aspect, which may be combined with any other aspect or embodiment, the present disclosure relates to a method of reducing pollution-induced MAM production in mitochondria by applying to human skin a composition comprising niacinamide, alpine edelweiss extract, rice (rice) sake lees concentrate, and panthenol.

[0085] In some embodiments, the composition further comprises at least one of: water, adenosine, a humectant, a photoprotective filter, an antioxidant, a preservative, a gelling agent, a solvent, a pH balancing agent, and a surfactant.

[0086] In some embodiments, the moisturizer includes at least one of: Buddleja macrophylla extract, thyme extract, caprylyl glycol, glycerin, 1,2-hexanediol, butylene glycol, or any combination thereof.

[0087] In some embodiments, the personal care composition further comprises, by weight of the total composition, 0.01%-2% adenosine, 0.0001%-3% Buddleja macrophylla extract, and 0.0001%-3% thyme extract.

[0088] In some embodiments, the photoprotective filter comprises at least one of zinc oxide, titanium dioxide, and iron oxide.

[0089] In another aspect, which may be combined with any other aspect or embodiment, the present disclosure relates to a method of alleviating pollution-induced mitochondrial membrane depolarization by applying to human skin a composition comprising: niacinamide, alpine edelweiss extract, rice (rice) sake lees concentrate, and panthenol.

[0090] In some embodiments, the composition further comprises at least one of: water, adenosine, a humectant, a photoprotective filter, an antioxidant, a preservative, a gelling agent, a solvent, a pH balancing agent, and a surfactant.

[0091] In some embodiments, the moisturizer includes at least one of: Buddleja macrophylla extract, thyme extract, caprylyl glycol, glycerin, 1,2-hexanediol, butylene glycol, or any combination thereof.

[0092] In some embodiments, the personal care composition further comprises, by weight of the total composition, 0.01%-2% adenosine, 0.0001%-3% Buddleja macrophylla extract, and 0.0001%-3% thyme extract.

[0093] In some embodiments, the photoprotective filter comprises at least one of zinc oxide, titanium dioxide, and iron oxide.

[0094] In another aspect, which may be combined with any other aspect or embodiment, the present disclosure relates to a method of inducing expression of procollagen and elastin in the skin by topically applying to the skin a composition comprising: niacinamide, Edelweiss (alpine edelweiss) extract, Oryza sativa (rice) sake lees concentrate, and panthenol, wherein the personal care composition does not contain retinol.

[0095] In some embodiments, the composition further comprises at least one of: water, adenosine, a humectant, a photoprotective filter, an antioxidant, a preservative, a gelling agent, a solvent, a pH balancing agent, and a surfactant.

[0096] In some embodiments, the moisturizer includes at least one of: Buddleja macrophylla extract, thyme extract, caprylyl glycol, glycerin, 1,2-hexanediol, butylene glycol, or any combination thereof.

[0097] In some embodiments, the personal care composition further comprises, by weight of the total composition, 0.01%-2% adenosine, 0.0001%-3% Buddleja macrophylla extract, and 0.0001%-3% thyme extract.

[0098] In some embodiments, the photoprotective filter comprises at least one of zinc oxide, titanium dioxide, and iron oxide.

[0099] In another aspect, which may be combined with any other aspect or embodiment, the present disclosure relates to a method of reducing IL-8 and PGE-2 expression in the skin by topically applying to the skin a composition comprising: niacinamide, Edelweiss (alpine edelweiss) extract, Oryza sativa (rice) sake lees concentrate, and panthenol, wherein the personal care composition does not contain retinol.

[0100] In some embodiments, the composition further comprises at least one of: water, adenosine, a humectant, a photoprotective filter, an antioxidant, a preservative, a gelling agent, a solvent, a pH balancing agent, and a surfactant.

[0101] In some embodiments, the moisturizer includes at least one of: Buddleja macrophylla extract, thyme extract, caprylyl glycol, glycerin, 1,2-hexanediol, butylene glycol, or any combination thereof.

[0102] In some embodiments, the personal care composition further comprises, by weight of the total composition, 0.01%-2% adenosine, 0.0001%-3% Buddleja macrophylla extract, and 0.0001%-3% thyme extract.

[0103] In some embodiments, the photoprotective filter comprises at least one of zinc oxide, titanium dioxide, and iron oxide. BRIEF DESCRIPTION OF THE DRAWINGS

[0104] Figure 1 Shown are the results of a skin sensitivity questionnaire for subjects using an embodiment of a composition according to the present disclosure.

[0105] Figure 2 Shown are the results of a TEWL / hydration assay performed on subjects using examples of personal care compositions according to the present disclosure.

[0106] Figure 3 Shown are the results of clinical scoring of skin treated with examples of compositions according to the present disclosure.

[0107] Figure 4 Shown are the results of a skin sensitivity questionnaire for subjects exposed to embodiments of compositions according to the present disclosure.

[0108] Figure 5 Shown are the results of a TEWL / hydration assay performed on subjects using yet another embodiment of a composition according to the present disclosure.

[0109] Figure 6The effect of personal care compositions (shown as treatments) on NADPH-oxidase activity is shown. NE-NTC: unexposed, untreated cells; DPI: diphenyliodonium, a standard NADPH oxidase inhibitor; PE-NTC: cells exposed to pollution and untreated; PE+IC94214 0.005%: exposed to pollution and treated. *** : p<0.001; ##: p<0.01, #: p<0.05. Bars are standard deviations.

[0110] Figure 7 is a representation of the mitochondrial membrane potential of primary human fibroblasts derived from mature donors in unexposed and untreated cells (NE-NTC) and cells exposed to standardized urban pollutants (PE-NTC) with and without treatment with (personal care composition). CCCP treatment and exposure to pollutants were compared to NE-NTC. Pollutant-exposed cells treated with personal care composition were compared to PE-NTC. *** : p<0.001; ##: p<0.01, #: p<0.05, #:p<0.05.

[0111] Fig. 8A Parameters measured in the mitochondrial fusion-fission assay are shown.

[0112] Figure 8B Results of mitochondrial fusion experiments are shown. Contamination resulted in long mitochondria and reduced mitochondrial fusion / hyperfusion. Treatment with an instant personal care product (shown as PE-treatment) restored mitochondrial fusion.

[0113] Figure 8C Results of mitochondrial fission experiments are shown. Pollution leads to increased mitochondrial fission / hyperfission. Treatment with instant personal care products (shown as PE-treatment) restores mitochondrial fission.

[0114] Fig. 9 Results of mitochondrial network analysis are shown. Normal cells have healthy branching mitochondrial networks (left panel). Pollution causes these networks to collapse and disintegrate (middle panel). Treatment with a personal care composition restores healthy mitochondrial network structure (right panel).

[0115] Fig.10 Shown is the quantification of ER-mitochondria interactions on MAMs of unexposed and untreated cells (NE-NTC) and cells exposed to standardized urban pollutants (PE-NTC) with and without treatment with a personal care composition (PE-treated).

[0116] Fig.11The number of viable cells per field under different experimental conditions is shown. Error bars represent standard error of the mean.

[0117] Fig.12 The effect of niacinamide (high and low concentrations) and a personal care composition (shown as Composition B, diluted to contain a niacinamide concentration equal to the "low" niacinamide concentration) on NADPH-oxidase activity is shown. NE-NTC: unexposed, untreated cells; PE-NTC: cells exposed to pollution and untreated; PE+IC94214 0.005%: exposed to pollution and treated. * : p<0.05; #: p<0.05, ###: p<0.0001. Bars are standard deviations.

[0118] Fig.13 Shown is the quantification of ER-mitochondria interactions on the MAMs of unexposed and untreated cells (NE-NTC) and cells exposed to standardized urban pollutants (PE-NTC) with and without treatment with nicotinamide ("low" concentration) and a personal care composition according to the present disclosure (Composition B, diluted to contain a nicotinamide concentration equal to the "low" nicotinamide concentration). *** : p<0.0001; ##: P<0.01. Bars are standard deviations. DETAILED DESCRIPTION

[0119] definition

[0120] Unless otherwise indicated, all percentages and ratios used herein are by weight of the total composition. Unless otherwise indicated, it will be understood that all measurements should be made under ambient conditions, wherein "ambient conditions" means conditions at about 25° C., at about one atmosphere of pressure, and at about 50% relative humidity. All numerical ranges include narrower ranges; the upper and lower limits specified are combinable to produce additional ranges not explicitly specified.

[0121] The compositions of the present disclosure may include, consist essentially of, or consist of the components described herein. As used herein, "consisting essentially of" means that the composition or component may include additional ingredients, but only when the additional ingredients do not materially change the basic and novel characteristics of the claimed composition or method.

[0122] As used herein, the term "about" refers to ± 10% of a given value.

[0123] As used in reference to a composition, the terms "apply" or "application" means applying or spreading a composition of the present disclosure onto keratinous tissue (eg, epidermis).

[0124] The term "derivative" encompasses ester, ether, amide, hydroxy and / or salt structural analogs of the compound of interest.

[0125] The term "dermatologically acceptable" means that the compositions or components described are suitable for contact with human skin tissue without undue toxicity, incompatibility, instability, allergic response, and the like.

[0126] The term "keratinous tissue" refers to the keratin-containing layer that is the outermost protective layer of mammals (eg, humans, dogs, cats, etc.), including but not limited to skin, lips, hair, toenails, fingernails, cuticles, hooves, etc.

[0127] As used herein, the term "pH balancing agent" refers to any compound (e.g., an acid or base) that can be used to adjust the pH of a composition to a specific value (e.g., 7, 8, 9, etc.) or a specific range (e.g., pH = about 5 to about 7, about 7 to about 9, etc.). In some embodiments, the pH balancing agent is added to the composition in an amount effective to adjust the pH level of the composition to about 7 or higher, such as about 7 or about 8, but not more than about 8.5.

[0128] In some embodiments, the pH balancing agent is added to the composition in an amount effective to adjust the pH level of the composition to about 7 or less, such as about 7, about 6, about 5, or about 4. In some embodiments, the pH balancing agent is added to the composition in an amount effective to adjust the pH level of the composition to about 5 to about 7.

[0129] Exemplary pH balancing agents include, but are not limited to, ammonium aluminum sulfate, ammonium bicarbonate, ammonium carbonate, diammonium citrate, monoammonium citrate, ammonium hydroxide, diammonium phosphate, monoammonium phosphate, calcium acetate, calcium acid pyrophosphate, calcium carbonate, calcium chloride, calcium citrate, calcium fumarate, calcium gluconate, calcium hydroxide, calcium lactate, calcium oxide, dicalcium phosphate, monocalcium phosphate, tricalcium phosphate, calcium sulfate, cream of tartar, glucono delta lactone, magnesium carbonate, magnesium citrate, magnesium fumarate, magnesium hydroxide, magnesium oxide, magnesium phosphate, magnesium sulfate, manganese sulfate, potassium acid tartrate, sulfuric acid Potassium aluminum, potassium bicarbonate, potassium carbonate, potassium chloride, potassium citrate, potassium fumarate, potassium hydroxide, potassium lactate, dipotassium phosphate, tripotassium phosphate, potassium sulfate, potassium tartrate, potassium tripolyphosphate, sodium acetate, sodium acid pyrophosphate, sodium acid tartrate, sodium aluminum phosphate, sodium aluminum sulfate, sodium bicarbonate, sodium bisulfate, sodium carbonate, sodium citrate, sodium fumarate, sodium gluconate, sodium hexametaphosphate, sodium hydroxide, sodium lactate, disodium phosphate, monosodium phosphate, trisodium phosphate, sodium potassium hexametaphosphate, potassium sodium tartrate, disodium tripolyphosphate, tetrasodium pyrophosphate and sodium tripolyphosphate.

[0130] As used herein, the term "pollution" refers to a polluted environment, including pollutants such as metals (e.g., lead), hazardous chemicals (e.g., polyaromatic hydrocarbons (PAHs), nitro-PAHs, polychlorinated biphenyls (PCBs), chlorinated pesticides, ozone, sulfur dioxide, carbon monoxide, nitrogen dioxide, etc.), dust, and particulate matter of micron diameter (e.g., particulate matter of about 10 microns ("PM 10"), or particulate matter of about 2.5 microns ("PM 2.5"). In some embodiments, the term "pollution" includes polluted air ("air pollution") or water ("water pollution").

[0131] In some embodiments, air pollution is measured by the Air Quality Index (AQI) used in China. In some embodiments, the AQI is above 100 ("light pollution"), above 150 ("moderate pollution"), above 200 ("heavy pollution"), or above 300 ("severe pollution"). In some embodiments, the AQI level is based on the levels of six atmospheric pollutants, namely sulfur dioxide (SO 2 ), nitrogen dioxide (NO 2 ), suspended particles with an aerodynamic diameter of less than 10 μm (PM 10), suspended particles with an aerodynamic diameter of less than 2.5 μm (PM 2.5), carbon monoxide (CO) and ozone (O 3 ).

[0132] The term "safe and effective amount" means an amount of a compound or composition sufficient to significantly induce a positive benefit.

[0133] The term "sensitive skin" refers to a neurosensory skin condition that results in different clinical signs, including irritation, erythema, or dry skin. More specifically, sensitive skin is a syndrome defined by the production of such sensations, such as burning, burning, pain, itching, or stinging, usually in response to stimuli that should not cause adverse sensations; in addition, sensitive skin is characterized by the absence of a link between these sensations and any skin pathology (Misery et al., Acta Derm Venereol 2017, 97: 4-6). Suitable assays for measuring sensitivity, inflammation, and skin irritation are known in the art. One such assay is the Jordan King assay, as described in Jordan, WP 1994, Jordan / King Modification of the Draize Repeated Injury Patch Test, Clairol Study No. 94046, Test Date October 3, 1994 to November 11, 1994, the entire contents of which are hereby incorporated by reference.

[0134] As used herein, the term "signs of skin aging" includes wrinkles, dryness, loss of elasticity, suppleness, firmness, radiance, and increased skin sensitivity.

[0135] The term "leave-on" when referring to a personal care composition means a composition that is intended to be applied to keratinous tissue and allowed to remain on the keratinous tissue. These leave-on compositions are to be distinguished from compositions that are applied to the skin and subsequently removed (in a few minutes or less) by washing, rinsing, wiping, etc. Leave-on compositions do not include rinse-off applications, such as shampoos, facial cleansers, hand soaps, shower gels, or body cleansers, etc. Leave-on compositions may be substantially free of cleaning or detersive surfactants. For example, a "leave-on composition" may stay on keratinous tissue for at least 15 minutes. For example, a leave-on composition may include less than 1% detersive surfactant, less than 0.5% detersive surfactant, or 0% surface surfactant. However, the composition may contain emulsifying or other processing surfactants that are not intended to provide any significant cleaning benefits when applied topically to the skin.

[0136] The term "rinse-off" means that the intended use of the personal care composition comprises a product that is applied to the keratinous tissue and then rinsed and / or wiped from the keratinous tissue within seconds to minutes of the application step. The product is typically applied and rinsed off in the same use event (e.g., showering).

[0137] The term "soluble" means that at least about 0.1 g of solute dissolves in 100 ml of solvent at 25°C and 1 atmosphere.

[0138] As used herein, the term "personal care composition" refers to compositions suitable for topical application to mammalian keratinous tissue.

[0139] Personal care compositions

[0140] The present disclosure provides personal care compositions that slow down aging or reduce signs of aging, improve radiance, and reduce wrinkles on sensitive skin. Without being committed to a particular theory, the personal care compositions of the present disclosure slow down aging and reduce signs of aging on sensitive skin by improving collagen production, regulating epidermal cell metabolism, and reducing inflammation and oxidative stress. The personal care compositions of the present disclosure strengthen the skin barrier, deeply moisturize the upper layers of the skin, protect and soothe the most sensitive skin, and rejuvenate the skin, intended to present a healthier, younger appearance. The personal care compositions of the present disclosure are suitable for sensitive skin and show results as early as 10-14 days of daily use.

[0141] One aspect of the present disclosure relates to a personal care composition comprising: (a) 0.1 wt%-10 wt% (e.g., 0.1 wt%, 0.2 wt%, 0.3 wt%, 0.4 wt%, 0.5 wt%, 0.6 wt%, 0.7 wt%, 0.8 wt%, 0.9 wt%, 1 wt%, 1.1 wt%, 1.2 wt%, 1.3 wt%, 1.4 wt%, 1.5 wt%, 1.6 wt%, 1.7 wt%, 1.8 wt%, 1.9 wt%, 2 wt%, 2.1 wt%, 2.2 wt%, 2.3 wt%, 2.4 wt%, 2.5 wt%, 2.6 wt%, 2.7 wt%, 2.8 wt%, 2.9 wt%); %, 3.1 wt%, 3.2 wt%, 3.3 wt%, 3.4 wt%, 3.5 wt%, 3.6 wt%, 3.7 wt%, 3.8 wt%, 3.9 wt%, 4 wt%, 4.1 wt%, 4.2 wt%, 4.3 wt%, 4.4 wt%, 4.5 wt%, 4.6 wt%, 4.7 wt%, 4.8 wt%, 4.9 wt%, 5 wt%, 5.1 wt%, 5.2 wt%, 5.3 wt%, 5.4 wt%, 5.5 wt%, 5.6 wt%, 5.7 wt%, 5.8 wt%, 5.9 wt%, 6 wt%, 6.1 wt%, 6.2 wt%, 6.3 wt%, 6.4 wt%, 6.5 wt%, 6.6 wt%, %, 6.7 wt%, 6.8 wt%, 6.9 wt%, 7 wt%, 7.1 wt%, 7.2 wt%, 7.3 wt%, 7.4 wt%, 7.5 wt%, 7.6 wt%, 7.7 wt%, 7.8 wt%, 7.9 wt%, 8 wt%, 8.1 wt%, 8.2 wt%, 8.3 wt%, 8.4 wt%, 8.5 wt%, 8.6 wt%, 8.7 wt%, 8.8 wt%, 8.9 wt%, 9 wt%, 9.1 wt%, 9.2 wt%, 9.3 wt%, 9.4 wt%, 9.5 wt%, 9.6 wt%, 9.7 wt%, 9.8 wt%, 9.9 wt%, 10 wt%) of niacinamide, (b) 0.0001 wt%, % to 10 wt % (e.g., 0.0001 wt %, 0.0002 wt %, 0.0003 wt %, 0.0004 wt %, 0.0005 wt %, 0.0006 wt %, 0.0007 wt %, 0.0008 wt %, 0.0009 wt %, 0.001 wt %, 0.002 wt %, 0.003 wt %, 0.004 wt %, 0.005 wt %, 0.006 wt %, 0.007 wt %, 0.008 wt %, 0.009 wt %, 0.01 wt %, 0.02 wt %, 0.03 wt %, 0.04 wt %, 0.05 wt %, 0.06 wt %, 0.07 wt %, 0.08 wt %, 0.%, 0.9 wt%, 0.1 wt%, 0.2 wt%, 0.3 wt%, 0.4 wt%, 0.5 wt%, 0.6 wt%, 0.7 wt%, 0.8 wt%, 0.9 wt%, 1 wt%, 1.1 wt%, 1.2 wt%, 1.3 wt%, 1.4 wt%, 1.5 wt%, 1.6 wt%, 1.7 wt%, 1.8 wt%, 1.9 wt%, 2 wt%, 2.1 wt%, 2.2 wt%, 2.3 wt%, 2.4 wt%, 2.5 wt%, 2.6 wt%, 2.7 wt%, 2.8 wt%, 2.9 wt%, 3 wt%, 3.1 wt%, 3.2 wt%, 3.3 wt%, 3.4 wt%, 3.5 wt%, 3.6 wt%, %, 3.7 wt%, 3.8 wt%, 3.9 wt%, 4 wt%, 4.1 wt%, 4.2 wt%, 4.3 wt%, 4.4 wt%, 4.5 wt%, 4.6 wt%, 4.7 wt%, 4.8 wt%, 4.9 wt%, 5 wt%, 5.1 wt%, 5.2 wt%, 5.3 wt%, 5.4 wt%, 5.5 wt%, 5.6 wt%, 5.7 wt%, 5.8 wt%, 5.9 wt%, 6 wt%, 6.1 wt%, 6.2 wt%, 6.3 wt%, 6.4 wt%, 6.5 wt%, 6.6 wt%, 6.7 wt%, 6.8 wt%, 6.9 wt%, 7 wt%, 7.1 wt%, 7.2 wt%, 7.3 %, 7.4%, 7.5%, 7.6%, 7.7%, 7.8%, 7.9%, 8%, 8.1%, 8.2%, 8.3%, 8.4%, 8.5%, 8.6%, 8.7%, 8.8%, 8.9%, 9%, 9.1%, 9.2%, 9.3%, 9.4%, 9.5%, 9.6%, 9.7%, 9.8%, 9.9%, 10% by weight of an extract of Edelweiss (alpine edelweiss), (c) 0.001% to 10% by weight (e.g., 0.001%, 0.002%, 0.003%, %, 0.004 wt%, 0.005 wt%, 0.006 wt%, 0.007 wt%, 0.008 wt%, 0.009 wt%, 0.1 wt%, 0.2 wt%, 0.3 wt%, 0.4 wt%, 0.5 wt%, 0.6 wt%, 0.7 wt%, 0.8 wt%, 0.9 wt%, 1 wt%, 1.1 wt%, 1.2 wt%, 1.3 wt%, 1.4 wt%, 1.5 wt%, 1.6 wt%, 1.7 wt%, 1.8 wt%, 1.9 wt%, 2 wt%, 2.1 wt%, 2.2 wt%, 2.3 wt%, 2.4 wt%, 2.5 wt%, 2.6 wt%, 2.7 wt%, 2.8 wt%, 2.9 wt%, 3 wt%, 3.1 wt%, 3.2 wt%, 3.3 wt%, 3.4 wt%, 3.5 wt%, 3.6 wt%, 3.7 wt%, 3.8 wt%, 3.9 wt%, 4 wt%, 4.1 wt%, 4.2 wt%, 4.3 wt%, 4.4 wt%, 4.5 wt%, 4.6 wt%, 4.7 wt%, 4.8 wt%, 4.9 wt%, 5 wt%, 5.1 wt%, 5.2 wt%, 5.3 wt%, 5.4 wt%, 5.5 wt%, 5.6 wt%, 5.7 wt%, 5.8 wt%, 5.9 wt%, 6 wt%, 6.1 wt%, 6.2 wt%, 6.3 wt%, 6.4 wt%, 6.5 wt%, %, 6.6% by weight, 6.7% by weight, 6.8% by weight, 6.9% by weight, 7% by weight, 7.1% by weight, 7.2% by weight, 7.3% by weight, 7.4% by weight, 7.5% by weight, 7.6% by weight, 7.7% by weight, 7.8% by weight, 7.9% by weight, 8% by weight, 8.1% by weight, 8.2% by weight, 8.3% by weight, 8.4% by weight, 8.5% by weight, 8.6% by weight, 8.7% by weight, 8.8% by weight, 8.9% by weight, 9% by weight, 9.1% by weight, 9.2% by weight, 9.3% by weight, 9.4% by weight, 9.5% by weight, 9.6% by weight, 9.7% by weight, 9.8% by weight, 9.9% by weight, 10% by weight) of rice (rice) sake lees concentrate %, (d) 0.1 wt % to 10 wt % (e.g., 0.1 wt %, 0.2 wt %, 0.3 wt %, 0.4 wt %, 0.5 wt %, 0.6 wt %, 0.7 wt %, 0.8 wt %, 0.9 wt %, 1 wt %, 1.1 wt %, 1.2 wt %, 1.3 wt %, 1.4 wt %, 1.5 wt %, 1.6 wt %, 1.7 wt %, 1.8 wt %, 1.9 wt %, 2 wt %, 2.1 wt %, 2.2 wt %, 2.3 wt %, 2.4 wt %, 2.5 wt %, 2.6 wt %, 2.7 wt %, 2.8 wt %, 2.9 wt %, 3 wt %, 3.1 wt %, 3.2 wt %, 3.3 wt %, 3.4 %, 3.5 wt%, 3.6 wt%, 3.7 wt%, 3.8 wt%, 3.9 wt%, 4 wt%, 4.1 wt%, 4.2 wt%, 4.3 wt%, 4.4 wt%, 4.5 wt%, 4.6 wt%, 4.7 wt%, 4.8 wt%, 4.9 wt%, 5 wt%, 5.1 wt%, 5.2 wt%, 5.3 wt%, 5.4 wt%, 5.5 wt%, 5.6 wt%, 5.7 wt%, 5.8 wt%, 5.9 wt%, 6 wt%, 6.1 wt%, 6.2 wt%, 6.3 wt%, 6.4 wt%, 6.5 wt%, 6.6 wt%, 6.7 wt%, 6.8 wt%, 6.9 wt%, 7 wt%, 7.1 wt%, 7.2 wt%, 7.3 wt%, 7.4 wt%, 7.5 wt%, 7.6 wt%, 7.7 wt%, 7.8 wt%, 7.9 wt%, 8 wt%, 8.1 wt%, 8.2 wt%, 8.3 wt%, 8.4 wt%, 8.5 wt%, 8.6 wt%, 8.7 wt%, 8.8 wt%, 8.9 wt%, 9 wt%, 9.1 wt%, 9.2 wt%, 9.3 wt%, 9.4 wt%, 9.5 wt%, 9.6 wt%, 9.7 wt% %, 9.8 wt%, 9.9 wt%, 10 wt%) of panthenol, and (e) 0.001 wt%-5 wt% (e.g., 0.001 wt%, 0.002 wt%, 0.003 wt%, 0.004 wt%, 0.005 wt%, 0.006 wt%, 0.007 wt%, 0.008 wt%, 0.009 wt%, 0.01 wt%, 0.02 wt%, 0.03 wt%, 0.04 wt%, 0.05 wt%, 0.06 wt%, 0.07 wt%) %, 0.08 wt%, 0.09 wt%, 0.1 wt%, 0.2 wt%, 0.3 wt%, 0.4 wt%, 0.5 wt%, 0.6 wt%, 0.7 wt%, 0.8 wt%, 0.9 wt%, 1 wt%, 1.1 wt%, 1.2 wt%, 1.3 wt%, 1.4 wt%, 1.5 wt%, 1.6 wt%, 1.7 wt%, 1.8 wt%, 1.9 wt%, 2 wt%, 2.1 wt%, 2.2 wt%, 2.3 wt%, 2.4 wt%, 2 .5 wt%, 2.6 wt%, 2.7 wt%, 2.8 wt%, 2.9 wt%, 3 wt%, 3.1 wt%, 3.2 wt%, 3.3 wt%, 3.4 wt%, 3.5 wt%, 3.6 wt%, 3.7 wt%, 3.8 wt%, 3.9 wt%, 4 wt%, 4.1 wt%, 4.2 wt%, 4.3 wt%, 4.4 wt%, 4.5 wt%, 4.6 wt%, 4.7 wt%, 4.8 wt%, 4.9 wt%, 5 wt%) of soybean-derived glycopeptide. .

[0142] Another aspect of the present disclosure is directed to a personal care composition comprising: (a) 0.1 wt%-4 wt% (e.g., 0.1 wt%, 0.2 wt%, 0.3 wt%, 0.4 wt%, 0.5 wt%, 0.6 wt%, 0.7 wt%, 0.8 wt%, 0.9 wt%, 1 wt%, 1.1 wt%, 1.2 wt%, 1.3 wt%, 1.4 wt%, 1.5 wt%, 1.6 wt%, 1.7 wt%, 1.8 wt%, 1.9 wt%, 2 wt%, 2.1 wt%, 2.2 wt%, 2.3 wt%, 2.4 wt%, 2.5 wt%, 2.6 wt%, 2.7 wt%, 2.8 wt%, 2.9 wt%); %, 3.1 wt%, 3.2 wt%, 3.3 wt%, 3.4 wt%, 3.5 wt%, 3.6 wt%, 3.7 wt%, 3.8 wt%, 3.9 wt%, 4 wt%) of niacinamide, (b) 0.0001 wt%-4 wt% (e.g., 0.0001 wt%, 0.0002 wt%, 0.0003 wt%, 0.0004 wt%, 0.0005 wt%, 0.0006 wt%, 0.0007 wt%, 0.0008 wt%, 0.0009 wt%, 0.001 wt%, 0.002 wt%, 0.003 wt%, 0.004 wt%, 0.005 wt%, 0.006 wt%, 0.007 wt%, 0.008 wt%, 0.009 wt%, %, 0.008 wt%, 0.009 wt%, 0.01 wt%, 0.02 wt%, 0.03 wt%, 0.04 wt%, 0.05 wt%, 0.06 wt%, 0.07 wt%, 0.08 wt%, 0.09 wt%, 0.1 wt%, 0.2 wt%, 0.3 wt%, 0.4 wt%, 0.5 wt%, 0.6 wt%, 0.7 wt%, 0.8 wt%, 0.9 wt%, 1 wt%, 1.1 wt%, 1.2 wt%, 1.3 wt%, 1.4 wt%, 1.5 wt%, 1.6 wt%, 1.7 wt%, 1.8 wt%, 1.9 wt%, 2 wt%, 2.1 wt%, 2.2 wt%, 2.3 wt% %, 2.4 wt%, 2.5 wt%, 2.6 wt%, 2.7 wt%, 2.8 wt%, 2.9 wt%, 3 wt%, 3.1 wt%, 3.2 wt%, 3.3 wt%, 3.4 wt%, 3.5 wt%, 3.6 wt%, 3.7 wt%, 3.8 wt%, 3.9 wt%, 4 wt%) of an extract of Edelweiss (alpine edelweiss), (c) 0.001 wt%-2 wt% (e.g., 0.001 wt%, 0.002 wt%, 0.003 wt%, 0.004 wt%, 0.005 wt%, 0.006 wt%, 0.007 wt%, 0.008 wt%, 0.009 wt%, 0.1 wt%, 0.2 wt%, 0.3 wt%, 0.4 wt%, 0.5 wt%, 0.6 wt%, 0.7 wt%, 0.8 wt%, 0.9 wt%, 1 wt%, 1.1 wt%, 1.2 wt%, 1.3 wt%, 1.4 wt%, 1.5 wt%, 1.6 wt%, 1.7 wt%, 1.8 wt%, 1.9 wt%, 2 wt%) of rice (paddy) sake lees concentrate, (d) 0.1 wt% to 3 wt% (e.g., 0.1 wt%, 0.2 wt%, 0.3 wt%, 0.4 wt%, 0.5 wt%, 0.6 wt%, 0.7 wt%, 0.8 wt%, 0.9 wt%, 1 wt%, 1.1 wt%, 1.2 wt%, 1.3 wt%, 1.4 wt%, 1.5 wt%, 1.6 wt%, 1.7 wt%, 1.8 wt%, 1.9 wt%, 2 wt%) of rice (rice) sake lees concentrate, %. (e) 0.002 wt % to 4 wt % (e.g., 0.002 wt %, 0.003 wt %, 0.004 wt %, 0.005 wt %, 0.006 wt %, 0.008 wt %, 0.010 wt %, 0.011 wt %, 0.012 wt %, 0.013 wt %, 0.014 wt %, 0.015 wt %, 0.016 wt %, 0.017 wt %, 0.018 wt %, 0.019 wt %, 0.020 wt %, 0.021 wt %, 0.022 wt %, 0.023 wt %, 0.024 wt %, 0.025 wt %, 0.026 wt %, 0.027 wt %, 0.028 wt %, 0.029 wt %, 0.030 wt %, 0.031 wt %, 0.032 wt %, 0.033 wt %, 0.034 wt %, 0.035 wt %, 0.036 wt %, 0.037 wt %, 0.038 wt %, 0.039 wt %, 0.040 wt %, 0.041 wt %, 0.042 wt %, 0.04 wt%, 0.005 wt%, 0.006 wt%, 0.007 wt%, 0.008 wt%, 0.009 wt%, 0.01 wt%, 0.02 wt%, 0.03 wt%, 0.04 wt%, 0.05 wt%, 0.06 wt%, 0.07 wt%, 0.08 wt%, 0.09 wt%, 0.1 wt%, 0.2 wt%, 0.3 wt%, 0.4 wt%, 0.5 wt%, 0.6 wt%, 0.7 wt%, 0.8 wt%, 0.9 wt%, 1 wt%, 1.1 wt%, 1.2 %, 1.3 wt%, 1.4 wt%, 1.5 wt%, 1.6 wt%, 1.7 wt%, 1.8 wt%, 1.9 wt%, 2 wt%, 2.1 wt%, 2.2 wt%, 2.3 wt%, 2.4 wt%, 2.5 wt%, 2.6 wt%, 2.7 wt%, 2.8 wt%, 2.9 wt%, 3 wt%, 3.1 wt%, 3.2 wt%, 3.3 wt%, 3.4 wt%, 3.5 wt%, 3.6 wt%, 3.7 wt%, 3.8 wt%, 3.9 wt%, 4 wt%) of soybean-derived glycopeptide.

[0143] Another aspect of the present disclosure is directed to a personal care composition comprising: (a) 0.1 wt%-10 wt% (e.g., 0.1 wt%, 0.2 wt%, 0.3 wt%, 0.4 wt%, 0.5 wt%, 0.6 wt%, 0.7 wt%, 0.8 wt%, 0.9 wt%, 1 wt%, 1.1 wt%, 1.2 wt%, 1.3 wt%, 1.4 wt%, 1.5 wt%, 1.6 wt%, 1.7 wt%, 1.8 wt%, 1.9 wt%, 2 wt%, 2.1 wt%, 2.2 wt%, 2.3 wt%, 2.4 wt%, 2.5 wt%, 2.6 wt%, 2.7 wt%, 2.8 wt%, 2.9 wt%); %, 3.1 wt%, 3.2 wt%, 3.3 wt%, 3.4 wt%, 3.5 wt%, 3.6 wt%, 3.7 wt%, 3.8 wt%, 3.9 wt%, 4 wt%, 4.1 wt%, 4.2 wt%, 4.3 wt%, 4.4 wt%, 4.5 wt%, 4.6 wt%, 4.7 wt%, 4.8 wt%, 4.9 wt%, 5 wt%, 5.1 wt%, 5.2 wt%, 5.3 wt%, 5.4 wt%, 5.5 wt%, 5.6 wt%, 5.7 wt%, 5.8 wt%, 5.9 wt%, 6 wt%, 6.1 wt%, 6.2 wt%, 6.3 wt%, 6.4 wt%, 6.5 wt%, 6.6 wt%, %, 6.7 wt%, 6.8 wt%, 6.9 wt%, 7 wt%, 7.1 wt%, 7.2 wt%, 7.3 wt%, 7.4 wt%, 7.5 wt%, 7.6 wt%, 7.7 wt%, 7.8 wt%, 7.9 wt%, 8 wt%, 8.1 wt%, 8.2 wt%, 8.3 wt%, 8.4 wt%, 8.5 wt%, 8.6 wt%, 8.7 wt%, 8.8 wt%, 8.9 wt%, 9 wt%, 9.1 wt%, 9.2 wt%, 9.3 wt%, 9.4 wt%, 9.5 wt%, 9.6 wt%, 9.7 wt%, 9.8 wt%, 9.9 wt%, 10 wt%) of niacinamide, (b) 0.0001 wt%, % to 10 wt % (e.g., 0.0001 wt %, 0.0002 wt %, 0.0003 wt %, 0.0004 wt %, 0.0005 wt %, 0.0006 wt %, 0.0007 wt %, 0.0008 wt %, 0.0009 wt %, 0.001 wt %, 0.002 wt %, 0.003 wt %, 0.004 wt %, 0.005 wt %, 0.006 wt %, 0.007 wt %, 0.008 wt %, 0.009 wt %, 0.01 wt %, 0.02 wt %, 0.03 wt %, 0.04 wt %, 0.05 wt %, 0.06 wt %, 0.07 wt %, 0.08 wt %, 0.0.9 wt%, 0.1 wt%, 0.2 wt%, 0.3 wt%, 0.4 wt%, 0.5 wt%, 0.6 wt%, 0.7 wt%, 0.8 wt%, 0.9 wt%, 1 wt%, 1.1 wt%, 1.2 wt%, 1.3 wt%, 1.4 wt%, 1.5 wt%, 1.6 wt%, 1.7 wt%, 1.8 wt%, 1.9 wt%, 2 wt%, 2.1 wt%, 2.2 wt%, 2.3 wt%, 2.4 wt%, 2.5 wt%, 2.6 wt%, 2.7 wt%, 2.8 wt%, 2.9 wt%, 3 wt%, 3.1 wt%, 3.2 wt%, 3.3 wt%, 3.4 wt%, 3.5 wt%, 3.6 %, 3.7% by weight, 3.8% by weight, 3.9% by weight, 4% by weight, 4.1% by weight, 4.2% by weight, 4.3% by weight, 4.4% by weight, 4.5% by weight, 4.6% by weight, 4.7% by weight, 4.8% by weight, 4.9% by weight, 5% by weight, 5.1% by weight, 5.2% by weight, 5.3% by weight, 5.4% by weight, 5.5% by weight, 5.6% by weight, 5.7% by weight, 5.8% by weight, 5.9% by weight, 6% by weight, 6.1% by weight, 6.2% by weight, 6.3% by weight, 6.4% by weight, 6.5% by weight, 6.6% by weight, 6.7% by weight, 6.8% by weight, 6.9% by weight, 7% by weight, 7.1% by weight, 7.2% by weight, 7 %. (c) 0.001 wt % to 10 wt % (e.g., 0.001 wt %, 0.002 wt %, 0.003 wt %) of an extract of Edelweiss (alpine edelweiss), (d) 0.001 wt % to 10 wt % (e.g., 0.001 wt %, 0.002 wt %, 0.003 wt %) of an extract of Edelweiss (alpine edelweiss), (e) 0.001 wt %, 0.002 wt %, 0.003 wt %, %, 0.004 wt%, 0.005 wt%, 0.006 wt%, 0.007 wt%, 0.008 wt%, 0.009 wt%, 0.01 wt%, 0.02 wt%, 0.03 wt%, 0.04 wt%, 0.05 wt%, 0.06 wt%, 0.07 wt%, 0.08 wt%, 0.09 wt%, 0.1 wt%, 0.2 wt%, 0.3 wt%, 0.4 wt%, 0.5 wt%, 0.6 wt%, 0.7 wt%, 0.8 wt%, 0.9 wt%, 1 wt%, 1.1 wt%, 1.2 wt%, 1.3 wt%, 1.4 wt%, 1.5 wt%, 1.6 wt%, 1.7 wt%, 1.8 wt%, 1.9 wt%, 2 wt%, 2.1 wt%, 2.2 wt%, 2.3 wt%, 2.4 wt%, 2.5 wt%, 2.6 wt%, 2.7 wt%, 2.8 wt%, 2.9 wt%, 3 wt%, 3.1 wt%, 3.2 wt%, 3.3 wt%, 3.4 wt%, 3.5 wt%, 3.6 wt%, 3.7 wt%, 3.8 wt%, 3.9 wt%, 4 wt%, 4.1 wt%, 4.2 wt%, 4.3 wt%, 4.4 wt%, 4.5 wt%, 4.6 wt%, 4.7 wt%, 4.8 wt%, 4.9 wt%, 5 wt%, 5.1 wt%, 5.2 wt%, 5.3 wt%, 5.4 wt% %, 5.5 wt%, 5.6 wt%, 5.7 wt%, 5.8 wt%, 5.9 wt%, 6 wt%, 6.1 wt%, 6.2 wt%, 6.3 wt%, 6.4 wt%, 6.5 wt%, 6.6 wt%, 6.7 wt%, 6.8 wt%, 6.9 wt%, 7 wt%, 7.1 wt%, 7.2 wt%, 7.3 wt%, 7.4 wt%, 7.5 wt%, 7.6 wt%, 7.7 wt%, 7.8 wt%, 7.9 wt%, 8 wt%, 8.1 wt%, 8.2 wt%, 8.3 wt%, 8.4 wt%, 8.5 wt%, 8.6 wt%, 8.7 wt%, 8.8 wt%, 8.9 wt%, 9 wt%, 9.1 wt%. %, 9.2 wt%, 9.3 wt%, 9.4 wt%, 9.5 wt%, 9.6 wt%, 9.7 wt%, 9.8 wt%, 9.9 wt%, 10 wt%) of rice (pasture) sake lees concentrate, and (d) 0.1 wt%-10 wt% (e.g., 0.1 wt%, 0.2 wt%, 0.3 wt%, 0.4 wt%, 0.5 wt%, 0.6 wt%, 0.7 wt%, 0.8 wt%, 0.9 wt%, 1 wt%, 1.1 wt%, 1.2 wt%, 1.3 wt%, 1.4 wt%, 1.5 wt%, 1.6 wt%, 1.7 wt%, 1.8 wt%, 1.9 wt%, 2 wt%, 2.1 wt%, 2.2 wt%) of rice (pasture) sake lees concentrate %, 2.3 wt%, 2.4 wt%, 2.5 wt%, 2.6 wt%, 2.7 wt%, 2.8 wt%, 2.9 wt%, 3 wt%, 3.1 wt%, 3.2 wt%, 3.3 wt%, 3.4 wt%, 3.5 wt%, 3.6 wt%, 3.7 wt%, 3.8 wt%, 3.9 wt%, 4 wt%, 4.1 wt%, 4.2 wt%, 4.3 wt%, 4.4 wt%, 4.5 wt%, 4.6 wt%, 4.7 wt%, 4.8 wt%, 4.9 wt%, 5 wt%, 5.1 wt%, 5.2 wt%, 5.3 wt%, 5.4 wt%, 5.5 wt%, 5.6 wt%, 5.7 wt%, 5.8 wt%, 5.%, 9.1 wt%, 9.2 wt%, 9.3 wt%, 9.4 wt%, 9.5 wt%, 9.6 wt%, 9.7 wt%, 9.8 wt%, 9.9 wt%, 10 wt% panthenol). .

[0144] In some embodiments, "niacinamide" comprises the formula:

[0145] Derivatives thereof; and salts of any of the foregoing.

[0146] In some embodiments, the personal care composition includes 0.1 wt%-2 wt% (e.g., 0.1 wt%, 0.2 wt%, 0.3 wt%, 0.4 wt%, 0.5 wt%, 0.6 wt%, 0.7 wt%, 0.8 wt%, 0.9 wt%, 1 wt%, 1.1 wt%, 1.2 wt%, 1.3 wt%, 1.4 wt%, 1.5 wt%, 1.6 wt%, 1.7 wt%, 1.8 wt%, 1.9 wt%, 2 wt%) of niacinamide. In some embodiments, the personal care composition includes 0.5 wt%-1.5 wt% (e.g., 0.5 wt%, 0.6 wt%, 0.7 wt%, 0.8 wt%, 0.9 wt%, 1 wt%, 1.1 wt%, 1.2 wt%, 1.3 wt%, 1.4 wt%, 1.5 wt%) of niacinamide.

[0147] In some embodiments, the edelweiss extract is as described in WO2001 / 087256 and EP 2623094. In some embodiments, the edelweiss extract is produced by DSM Nutritional Products under the trade name Products sold by EDELWEISS. In some embodiments, the Edelweiss (alpine edelweiss) extract includes chlorogenic acid, luteolin-4'-O-glucoside, apigenin-7-O-glucoside, luteolin and leontopodic acid as bioactive agents. In some embodiments, the Edelweiss extract contains tannins. In some embodiments, the Edelweiss extract is mixed with other agents such as glycerol, glycerin, water, citric acid, sodium benzoate, ethanol and potassium sorbate. In some embodiments, the personal care composition includes 0.1%-2% by weight (e.g., 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%) of Edelweiss (alpine edelweiss). In some embodiments, the personal care composition includes 0.5%-1.5% by weight (e.g., 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%) of Edelweiss (alpine edelweiss). In some embodiments, the personal care composition includes 0.0001 wt%-0.5 wt% (e.g., 0.0001 wt%, 0.0002 wt%, 0.0003 wt%, 0.0004 wt%, 0.0005 wt%, 0.0006 wt%, 0.0007 wt%, 0.0008 wt%, 0.0009 wt%, 0.001 wt%, 0.002 wt%, 0.003 wt%, 0.004 wt%, 0.005%, 0.006%, 0.007%, 0.008%, 0.009%, 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.1%, 0.2%, 0.3%, 0.4% or 0.5% by weight) of Edelweiss (Alpine Leontopodium alpinum).

[0148] In some embodiments, the Edelweiss (alpine edelweiss) extract is provided in the form of a solution (e.g., from a manufacturer), the solution comprising an alpine edelweiss extract and a solvent (e.g., water, glycerin, or a combination thereof) and other ingredients (e.g., citric acid, sodium benzoate, potassium sorbate, etc.), and this solution is subsequently added to the personal care composition of the present disclosure. In some embodiments, the concentration of the alpine edelweiss extract in the provided solution (e.g., obtained from a manufacturer) is less than or equal to 10 wt.%, 9.5 wt.%, 9 wt.%, 8.5 wt.%, 8 wt.%, 7.5 wt.%, 7 wt.%, 6.5 wt.%, 6 wt.%, 5.5 wt.%, 5 wt.%, 4.5 wt.%, 4 wt.%, 3.5 wt.%, 3 wt.%, 2.9 wt.%, 3.5 ... %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. For example, a concentration of 0.0001% to 10% of an Edelweiss (alpine edelweiss) extract relative to the total weight of the personal care composition may indicate the concentration of a solution including an Edelweiss (alpine edelweiss) extract.

[0149] Alternatively, in some embodiments, a concentration of 0.0001%-5% Edelweiss (alpine edelweiss) extract (or any other concentration described herein) relative to the total weight of the personal care composition can represent the concentration of "dry" Edelweiss (alpine edelweiss) extract plant activity. As a non-limiting example, relative to the total weight of the personal care composition, if the Edelweiss (alpine edelweiss) extract is provided in the form of a solution added, for example, at 3.0 wt.%, and the "dry weight" of the soy-derived glycopeptide in the provided solution is 8.5 wt.%, relative to the total weight of the provided solution, then the "dry weight" of the soy-derived glycopeptide in the personal care composition will be 0.255 wt.% relative to the total weight of the personal care composition.

[0150] In certain embodiments, rice (rice) wine dregs concentrate includes amino acids, oleic acid, linolenic acid, phytic acid, palmitic acid and vitamin B derivatives as bioactive agents. In certain embodiments, rice (rice) wine dregs concentrate includes water, glycerol, rice wine dregs extract, propylene glycol, 1,2, hexanediol and ethylhexylglycerol. In certain embodiments, the pH of rice (rice) wine dregs concentrate is between 4.0 and 7.0. In certain embodiments, the specific gravity (d20 / 20) of rice (rice) wine dregs concentrate is between 0.99 and 1.05.

[0151] In some embodiments, the personal care composition includes 0.1 wt%-2 wt% (e.g., 0.1 wt%, 0.2 wt%, 0.3 wt%, 0.4 wt%, 0.5 wt%, 0.6 wt%, 0.7 wt%, 0.8 wt%, 0.9 wt%, 1 wt%, 1.1 wt%, 1.2 wt%, 1.3 wt%, 1.4 wt%, 1.5 wt%, 1.6 wt%, 1.7 wt%, 1.8 wt%, 1.9 wt%, 2 wt%) of rice (rice) wine dregs concentrate. In some embodiments, the personal care composition includes 0.5 wt%-1.5 wt% (e.g., 0.5 wt%, 0.6 wt%, 0.7 wt%, 0.8 wt%, 0.9 wt%, 1 wt%, 1.1 wt%, 1.2 wt%, 1.3 wt%, 1.4 wt%, 1.5 wt%) of rice (rice) wine dregs concentrate. In some embodiments, the personal care composition includes 0.001 wt.%-1 wt.% (e.g., 0.001 wt.%, 0.002 wt.%, 0.003 wt.%, 0.004 wt.%, 0.005 wt.%, 0.006 wt.%, 0.007 wt.%, 0.008 wt.%, 0.009 wt.%, 0.1 wt.%, 0.2 wt.%, 0.3 wt.%, 0.4 wt.%, 0.5 wt.%, 0.6 wt.%, 0.7 wt.%, 0.8 wt.%, 0.9 wt.%, 1 wt.%) of rice (pasture) sake lees concentrate.

[0152] Similar to the Edelweiss (alpine edelweiss) extract, the concentration of the rice (rice) sake lees concentrate can be the concentration of the provided solution (e.g., from the manufacturer) relative to the total weight of the personal care composition, wherein the solution includes the active ingredients of the rice (rice) sake lees concentrate and one or more solvents (e.g., water, glycerol, propylene glycol, 1,2-hexanediol, ethylhexylglycerol, or a combination thereof). Alternatively, the concentration of the rice (rice) sake lees concentrate can be the "dry weight" concentration of the active ingredients of the rice (rice) sake lees concentrate relative to the total weight of the personal care composition. For example, if the provided solution including the rice (rice) sake lees concentrate is present in the personal care composition at a concentration of 1.0 wt.%, and the active ingredients of the rice (rice) sake lees concentrate are present in the provided solution at a concentration of 10 wt.%, then the total "dry weight" of the active ingredients in the rice (rice) sake lees concentrate will be 0.1 wt.% relative to the total weight of the personal care composition.

[0153] In some embodiments, the personal care composition further comprises 0.01%-2% (e.g., 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, or 2%) of adenosine by weight of the total composition.

[0154] In some embodiments, the personal care composition further comprises 0.0001% to 3% (e.g., 0.0001%, 0.0002%, 0.0003%, 0.0004%, 0.0005%, 0.0006%, 0.0007%, 0.0008%, 0.0009%, 0.001%, 0.002%, 0.003%, 0.004%, 0.005%, 0.006%, 0.007%, 0.008%, 0.009%, 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0. ... 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9% or 3%) of Buddleaf Herba Extract.

[0155] In some embodiments, the personal care composition further comprises 0.0001%-3% (e.g., 0.0001%, 0.0002%, 0.0003%, 0.0004%, 0.0005%, 0.0006%, 0.0007%, 0.0008%, 0.0009%, 0.001%, 0.002%, 0.003%, 0.004%, 0.005%, 0.006%, 0.007%, 0.008%, 0.009%, 0.01%, 0.02%, 0.03%, 0. ... .03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9% or 3%) of thyme extract.

[0156] Similar to Edelweiss (alpine edelweiss) extract and Oryza sativa (rice) sake grain concentrate, the reported concentration of Thyme extract or Buddleja macrophylla extract can be the concentration of the solution provided including these actives or the "dry weight" of these actives relative to the total weight of the personal care composition.

[0157] In some embodiments, "panthenol" comprises the formula:

[0158] Derivatives thereof; and salts of any of the foregoing.

[0159] In some embodiments, the personal care composition includes 0.1% to 2% (e.g., 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%) of panthenol. In some embodiments, the personal care composition includes 0.5% to 1.5% (e.g., 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%) of panthenol.

[0160] In some embodiments, the soy-derived glycopeptide is a glycopeptide derived from highly purified soy fiber. In some embodiments, the soy-derived glycopeptide can be blended with a stabilizer and a preservative. Exemplary soy-derived glycopeptides are sold.

[0161] In some embodiments, the soy-derived glycopeptide is provided (e.g., from a manufacturer) in a solution including the soy-derived glycopeptide (e.g., hydrolyzed soy flour) and a solvent (e.g., water, caprylyl glycol, 1,2-hexanediol, or a combination thereof), and the solution is subsequently added to the personal care composition of the present disclosure. In some embodiments, the concentration of soy-derived glycopeptide in a provided solution (e.g., obtained from a manufacturer) is less than or equal to 10 wt.%, 9 wt.%, 8 wt.%, 7 wt.%, 6 wt.%, 5 wt.%, 4 wt.%, 3 wt.%, 2.9 wt.%, 2.8 wt.%, 2.7 wt.%, 2.6 wt.%, 2.5 wt.%, 2.4 wt.%, 2.3 wt.%, 2.2 wt.%, 2.1 wt.%, 2.0 wt.%, 1.9 wt.%, 1.8 wt.%, 1.7 wt.%, 1.6 wt.%, 1.5 wt.%, 1.4 wt.%, 1.3 wt.%, 1.2 wt.%, 1.0 wt.%, 0.5 wt.%, 0.1 wt.% or less, relative to the weight of the provided solution. Therefore, in some embodiments, the concentration of soy-derived glycopeptide (as described herein) relative to the weight of the personal care composition indicates the concentration of the solution including the soy-derived glycopeptide (e.g., hydrolyzed soy flour). For example, a concentration of 0.001%-5% of soy-derived glycopeptide relative to the total weight of the personal care composition can indicate the concentration of the solution including the soy-derived glycopeptide.

[0162] Alternatively, in some embodiments, a concentration of 0.001%-5% of soy-derived glycopeptide relative to the total weight of the personal care composition may indicate the concentration of the "dry" soy-derived glycopeptide (e.g., hydrolyzed soy flour) itself. As a non-limiting example, relative to the total weight of the personal care composition, if the soy-derived glycopeptide (e.g., hydrolyzed soy flour) is provided in the form of a solution added at, for example, 2.0 wt.%, and the "dry weight" of the soy-derived glycopeptide in the provided solution is 3.0 wt.%, then relative to the total weight of the personal care composition, the "dry weight" of the soy-derived glycopeptide in the personal care composition will be 0.06 wt.%.

[0163] In some embodiments, the personal care composition does not include any retinoid or retinoid derivative.

[0164] In some embodiments, the personal care composition further comprises at least one of: water, an anti-dehydrating agent, a photoprotective filter, an antioxidant, a preservative, a gelling agent, a solvent, a pH balancing agent, and a surfactant.

[0165] In some embodiments, the anti-dehydration agent includes at least one of xylitol glucoside, anhydroxylitol, and xylitol. In some embodiments, the anti-dehydration agent includes each of xylitol glucoside, anhydroxylitol, and xylitol. In some embodiments, the anti-dehydration agent accounts for 0.01 wt%-0.5 wt% of the personal care composition.

[0166] In some embodiments, the photoprotective filter comprises at least one of zinc oxide, titanium dioxide, and iron oxide.

[0167] In some embodiments, the personal care composition further comprises at least one of: hydrolyzed hyaluronic acid, glycerin, sodium hydroxide, phenoxyethanol, xanthan gum, sodium polyacryloyldimethyl taurate, undecane, tridecane, tocopherol, dimethicone, titanium dioxide, tin oxide, and calcium aluminum borosilicate. In some embodiments, the personal care composition comprises each of: hydrolyzed hyaluronic acid, glycerin, sodium hydroxide, phenoxyethanol, xanthan gum, sodium polyacryloyldimethyl taurate, undecane, tridecane, tocopherol, dimethicone, titanium dioxide, tin oxide, and calcium aluminum borosilicate.

[0168] In some embodiments, the personal care composition includes at least one of: hydrolyzed hyaluronic acid (0.001 wt%-0.05 wt%), glycerin (0.1 wt%-7 wt%), sodium hydroxide (0.001 wt%-0.1 wt%), phenoxyethanol (0.1 wt%-1 wt%), xanthan gum (0.05 wt%-0.5 wt%), sodium polyacryloyldimethyl taurate (0.1 wt%-1.2 wt%), an emollient composition including undecane, tridecane and tocopherol (0.05 wt%-0.5 wt%), polydimethylsiloxane (0.5 wt%-5 wt%), a pigment composition including titanium dioxide, tin oxide and calcium aluminum borosilicate (0.005 wt%-0.05 wt%).

[0169] In some embodiments, the emollient composition comprises Cetiol Ultimate TM .

[0170] In some embodiments, the pigment composition includes Syncrystal Gold TM .

[0171] In some embodiments, the personal care composition further comprises an exfoliant. In some embodiments, the exfoliant is jojoba beads containing vitamin E.

[0172] In some embodiments, the personal care composition is a cream, lotion, gel, facial mask or spray. The personal care composition of the present disclosure can be a skin care product, an antiperspirant, a deodorant, a cosmetic or a hair care product. The personal care composition can be used as, for example, a moisturizer, a conditioner, an anti-aging compound, a skin whitening agent, a skin mask, a sunscreen, a sunless tanning agent, a shaving preparation, an aftershave, and a combination thereof. In certain embodiments, the composition is applied to other typical exposed areas of the face, neck, hands, arms, and body.

[0173] Personal care compositions may relate to various forms. Non-limiting examples include simple solutions (e.g., water or oil-based solutions), dispersions, and emulsions. Personal care compositions can be fluids or solids (gels, sticks, flowable solids, amorphous materials). In certain embodiments, personal care compositions are in the form of emulsions. Emulsions can generally be classified as having a continuous aqueous phase (e.g., oil-in-water and water-in-oil-in-water) or a continuous oil phase (e.g., water-in-oil and oil-in-water-in-oil).

[0174] In some embodiments, the personal care composition is a leave-on composition.

[0175] In some embodiments, the personal care composition is a rinse-off composition.

[0176] In certain embodiments, the personal care composition has a turbidity of from about 5 nephelometric turbidity units (NTU) to less than about 3000 NTU, 1000 NTU, 500 NTU, or 100 NTU.

[0177] In selected embodiments, the personal care composition can be in the form of at least one discrete visually different first phase and at least one discrete visually different second phase. For the purpose of selected embodiments, "visually different" means that the human eye can view the phase as a distinctly separated region (i.e., an emulsion or dispersion that is not a particle) alone. In certain embodiments, at least one phase forms a stable pattern in a transparent phase, such as a continuous or discontinuous line, spiral, curve or other geometric shape, wherein "in" means that one phase is substantially surrounded by another phase and does not contact the side of the container. Alternatively, these phases can form a swirl pattern, wherein the two phases alternately contact the side of the container, and wherein when viewed from the side of the transparent container, the width of each phase is substantially constant, but can be different from each other. Alternatively, these phases can form a marble pattern, wherein the phases alternately contact the side of the container, and wherein when viewed from the side of the transparent container, the width of each phase can vary throughout the composition. In one embodiment, the first phase is a transparent, clear or translucent aqueous phase, and the second phase is an opaque white or colored non-aqueous phase. In another alternative embodiment, at least one aqueous phase forms a pattern in a non-aqueous phase. In some embodiments, the instant personal care composition may include three or more visually distinct and stable phases.Discrete visually distinct multi-phase compositions are described in U.S. Patent Application Publication Nos. 2007 / 0297996, 2004 / 0057920, and 2004 / 0219119, the entire contents of which are incorporated by reference in their entirety.

[0178] Carrier

[0179] The personal care composition can include a carrier. The carrier can be selected for various reasons of stability, aesthetics, and / or compatibility with other materials present in the personal care composition.

[0180] Suitable carriers include water and / or water-soluble solvents. The personal care composition can include about 1% to about 95% by weight of water and / or water-equivalent solvents. The composition can include about 1%, 3%, 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85% or 90% to about 90%, 85%, 80%, 75%, 70%, 65%, 60%, 55%, 50%, 45%, 40%, 35%, 30%, 25%, 20%, 15%, 10% or 5% water and / or water-equivalent solvents. "Water-equivalent solvent" refers to a compound with the ability to dissolve materials similar to water. Suitable water-equivalent solvents include monohydric alcohols, dihydric alcohols, polyhydric alcohols, glycerol, glycols, polyalkylene glycols (such as polyethylene glycol), and mixtures thereof. Particularly suitable solvents include lower aliphatic alcohols, such as ethanol, propanol, butanol, isopropanol; glycols, such as 1,2-propylene glycol, 1,3-propylene glycol, butanediol, pentanediol, hexanediol, heptanediol, decanediol; glycerol; water and mixtures thereof. In certain embodiments, the personal care composition includes water, glycols, glycerol, and combinations thereof.

[0181] Suitable carrier also comprises oil.Personal care composition can comprise one or more oils of about 1 % by weight to about 95 % by weight.Composition can comprise one or more oils of about 1%, 3%, 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85% or 90% to about 90%, 85%, 80%, 75%, 70%, 65%, 60%, 55%, 50%, 45%, 40%, 35%, 30%, 25%, 20%, 15%, 10% or 5%.Oil can be used for solubilizing, dispersion or carry the material that is not suitable for water or water equivalent solvent.Suitable oil comprises silicone, hydrocarbon, ester, fatty amide, ether and its mixture.Oil can be fluid at room temperature.However, some personal care product forms (i.e. solid or semi-solid stick) may need non-fluid oil. Oils can be volatile or nonvolatile. "Nonvolatile" means a material that exhibits a vapor pressure of no more than about 0.2 mm Hg at one atmosphere at 25°C and / or a material that has a boiling point of at least about 300°C at one atmosphere. "Volatile" means a material that exhibits a vapor pressure of at least about 0.2 mm Hg at 20°C. Volatile oils can be used to provide a lighter feel when a heavy oil film is not desired.

[0182] Suitable oils include volatile oils. In certain embodiments, the viscosity of the volatile oil may be in the range of about 0.5 to about 5 centistokes at 25°C. Volatile oils may be used to promote faster drying of the skin care composition after application to the skin. Non-volatile oils are also suitable for the composition. Non-volatile oils are typically used for emollient and protective properties. The viscosity of the non-volatile oil may be in the range of about 5 to about 800,000 cst (or greater) or about 20 to about 200,000 cst.

[0183] Suitable silicone oils include polysiloxanes. The viscosity of the polysiloxanes at 25°C may range from about 0.5 to about 1,000,000 centistokes. Such polysiloxanes may be represented by the general formula:

[0184] R 3 SiO[R 2 SiO] x S i 3

[0185] wherein R is independently selected from hydrogen or C 1-30 linear or branched, saturated or unsaturated alkyl, phenyl or aryl, trialkylsiloxy; and x is an integer from 0 to about 10,000 selected to achieve the desired molecule. In certain embodiments, R is hydrogen, methyl or ethyl. Commercially available polysiloxanes include polydimethylsiloxanes, also known as polydimethylsiloxanes, examples of which include the DM-Fluid series from Shin-Etsu, the DM-Fluid series sold by Momentive Performance Materials Inc., and the DM-Fluid series sold by Momentive Performance Materials Inc. series and Dow Corning sold by Dow Corning Corporation 200 Series. Specific examples of suitable polydimethylsiloxanes include Dow 200 fluid (also known as PMX-200 Silicone Fluid).

[0186] Suitable polydimethylsiloxanes include those represented by the formula:

[0187] R 3 SiO[R 2 SiO] x [RR'SiO] y S i 3 ,

[0188] Wherein R and R' are each independently hydrogen or C1-30 linear or branched, saturated or unsaturated alkyl, aryl or trialkylsiloxy; and x and y are integers from 1 to 1,000,000 selected to achieve the desired molecular weight. Suitable silicones include phenyl dimethicone (Botansil from Botanigenics Inc. TM PD-151), diphenyl dimethicone (KF-53 and KF-54 from Shin-Etsu Chemical Co., Ltd.), phenyl trimethicone (556 Cosmetic Grade Fluid from Dow Corning) or trimethylsiloxyphenyl dimethicone (PDM-20, PDM-200 or PDM-1000 from Wacker-Belsil). Other examples include alkyl dimethicones in which at least R' is a fatty alkyl group (e.g., C 12-22 ). A suitable alkyl dimethicone is cetyl dimethicone, wherein R' is a linear C16 chain and R is a methyl group. Cetyl dimethicone is available from Dow Corning as s 2502 cosmetic fluid or from Evonik Goldschmidt GmbH as Abil Wax 9801 or 9814.

[0189] Cyclic silicones are a class of silicone oils that can be used in the personal care compositions of the present disclosure. The general formula of such silicones is:

[0190]

[0191] wherein R is independently selected from hydrogen or C 1-30 linear or branched, saturated or unsaturated alkyl, phenyl or aryl, trialkylsiloxy; and wherein n=3-8; and mixtures thereof. Typically, a mixture of cyclomethicones is used, wherein n is 4, 5 and / or 6. Commercially available cyclomethicones include Dow Corning UP-1001 Ultrapure Fluid (i.e., n=4), Dow Corning PMX-0245 (i.e. n=5), Dow Corning PMX-0245 (ie, n=6), Dow Corning 245 fluid (ie, n=4 and 5), and Dow Corning 345 fluid (ie, n=4, 5, and 6).

[0192] Other silicone oils suitable for personal care compositions include polymers having the general formula:

[0193] (R 1 ) a G 3-a -Si—(—OSiG 2 ) n -(—OSiG b (R1 ) 2-b ) m —O-SiG 3-a (R 1 ) a

[0194] Where G is hydrogen, phenyl, hydroxyl or C 1 -C 8 alkyl, preferably methyl; a is a number 0-3; b is 0 or 1, preferably 1; n is a number from 0 to 1,999 (alternatively, 49 to 499); m is an integer from 1 to 2,000 (alternatively, 1 to 10); the sum of n and m is a number from 1 to 2,000 (alternatively, 50 to 500); R 1 It conforms to the general formula (CH 2 ) q L is a monovalent group, wherein q is an integer having a value of 1 to 8, and L is selected from the following groups:

[0195] —N(R 2 )CH 2 —CH 2 —N(R 2 ) 2

[0196] —N(R 2 ) 2

[0197] —N(R 2 ) 3 A -

[0198] —N(R 2 )CH 2 —CH 2 —NR 2 H 2 A -

[0199] Where R 2 is hydrogen, phenyl or aryl or saturated hydrocarbon, preferably about C 1 to about C 20 An alkyl radical of alkyl and A is a halide ion. An exemplary silicone polymer is trimethylsilylamino polydimethylsiloxane, as shown in the following formula:

[0200]

[0201] Another exemplary silicone polymer is represented by the general formula:

[0202]

[0203] Where R 3 It is C1 To C 18 A monovalent hydrocarbon group, preferably an alkyl or alkenyl group, such as a methyl group; R 4 is a hydrocarbon, preferably C 1 To C 18 Alkylene or C 10 To C 18 Alkyleneoxy, more preferably C 1 To C 8 Alkyleneoxy; Q - is a halide, preferably a chloride; r is an average statistical value of 2 to 20, preferably 2 to 8; s is an average statistical value of 20 to 200, preferably 20 to 50. Such suitable polymers are known as UCARE SILICONE ALE 56 TM , available from Union Carbide. Other suitable silicone materials are disclosed in U.S. Patent Application Publication No. 2007 / 0039103A1.

[0204] Suitable hydrocarbon oils include straight or branched alkanes and olefins. Chain length can be selected according to desired functional properties (such as volatility). Suitable hydrocarbon oils can have 5-20 carbon atoms, or alternatively 8-16 carbon atoms. Suitable hydrocarbons include pentane, hexane, heptane, decane, dodecane, tetradecane, tridecane and C 8-20 Isoparaffins, such as those disclosed in U.S. Pat. Nos. 3,439,088 and 3,818,105. Suitable hydrocarbons include those sold by Permethyl Corporation under the trade name Suitable hydrocarbon oils may have greater than about 20 carbon atoms. Examples of such hydrocarbon oils include C 24-28 Olefins, C 30-45 Olefins, C 20-40 Isoparaffin, hydrogenated polyisobutene, polyisobutene, polydecene, hydrogenated polydecene, mineral oil, petrolatum, pentahydrosqualene, squalene, squalane, and mixtures thereof.

[0205] Other suitable oils comprise esters.Suitable esters contain at least 10 carbon atoms conventionally.These esters comprise esters (for example, monoesters, polyol esters and dicarboxylic acid esters and tricarboxylic acid esters) with the alkyl chain derived from fatty acid or alcohol.The alkyl of ester of the present invention can comprise or have other compatible functional groups covalently bonded thereto, such as amides and alkoxy moieties (for example, ethoxy or ether bonds etc.).Exemplary esters include but are not limited to isopropyl isostearate, hexyl laurate, isohexyl laurate, isohexyl palmitate, isopropyl palmitate, decyl oleate, isodecyl oleate, hexadecyl stearate, decyl stearate, isostearate isopropyl, dihexyl decyl adipate, lauryl lactate, myristyl lactate, hexadecyl lactate, oleyl stearate, oleyl oleate, oleyl myristate, lauryl acetate, hexadecyl propionate and oleyl adipate. Other suitable esters are further described in the Personal Care Products Council's International Cosmetic Ingredient Dictionary and Handbook, Thirteenth Edition, 2010, under the functional category of "Esters."

[0206] Other esters suitable for personal care compositions include monocarboxylic acid esters of the general formula R'COOR, wherein R' and R are linear or branched, saturated or unsaturated alkyl, aryl, wherein the sum of the carbon atoms in R' and R is at least 10. Suitable monoesters are alkyl benzoates, such as C 12-15 Alkyl benzoate.

[0207] Other esters suitable for personal care compositions include dialkyl esters, trialkyl esters, and alkenyl esters of carboxylic acids, such as C 4 To C 8 Esters of dicarboxylic acids (e.g., C esters of succinic acid, glutaric acid, and adipic acid) 1 To C 22 Esters, preferably C 1 To C 6 Specific non-limiting examples of di- and tri-alkyl and alkenyl esters of carboxylic acids include isocetyl stearoyl stearate, diisopropyl adipate, dibutyl adipate, and tristearoyl citrate.

[0208] Other esters suitable for personal care compositions include those known as polyol esters. Such polyol esters include alkylene glycol esters such as ethylene glycol mono- and di-fatty acid esters, diethylene glycol mono- and di-fatty acid esters, polyethylene glycol mono- and di-fatty acid esters, propylene glycol mono- and di-fatty acid esters, polypropylene glycol monooleate, polypropylene glycol 2000 monostearate, ethoxylated propylene glycol monostearate, glycerol mono- and di-fatty acid esters, polyglycerol poly-fatty acid esters, ethoxylated monostearate glyceryl, 1,3-butylene glycol monostearate, 1,3-butylene glycol distearate, polyoxyethylene polyol fatty acid esters, sorbitan fatty acid esters, and polyoxyethylene sorbitan fatty acid esters.

[0209] Still other esters suitable for personal care compositions include glycerides, including but not limited to monoglycerides, diglycerides, and triglycerides. For use in the compositions described herein, the glyceride can be a mixture of glycerol and a long chain carboxylic acid (e.g., C 10 To C 22 The monoesters, diesters and triesters of carboxylic acids. Various materials of these types can be obtained from plant and animal fats and oils, such as castor oil, safflower oil, cottonseed oil, corn oil, olive oil, cod liver oil, almond oil, avocado oil, palm oil, sesame oil, sweet almond oil, apricot kernel oil, camelina sativa oil, rapeseed oil, corn seed oil, linseed oil, coconut oil, lanolin oil, soybean oil, etc. Synthetic oils include but are not limited to triolein dilaurin and tristearin dilaurin. Other glycerides of fatty acids include monoglycerides, diglycerides and triglycerides of fatty acids, which are natural fats or oils that have been modified, such as stearin, diisostearate, polyglyceryl-3 isostearate, polyglyceryl-4 isostearate, polyglyceryl-6 ricinoleate, diolein, diisostearate, tetraisostearate, tricaprylin, distearate, linolein, myristic acid, isostearic acid, PEG castor oil, PEG oleic acid glyceride, PEG stearic acid glyceride, PEG tallow fatty acid glyceride, and the like.

[0210] Other suitable oils include fatty amides. Fatty amides include compounds having amide functional groups that are liquid at 25°C and insoluble in water. In certain embodiments, the fatty amide may have the general formula:

[0211]

[0212] Wherein R1 is an optionally functionalized, aliphatic, alicyclic or cyclic, saturated or unsaturated monovalent hydrocarbon radical containing 1 to 30 carbon atoms (alternatively, 1 to 22 carbon atoms); R2, R3 and R4 may be the same or different and are hydrogen or an optionally functionalized, aliphatic, alicyclic or cyclic, saturated or unsaturated monovalent hydrocarbon radical containing 1 to 30 carbon atoms, preferably 1 to 22 carbon atoms; r is 0 or 1; q is an integer from 0 to 2; and p is equal to 0 or 1. Specific fatty amides include N-acetyl-N-butylamino propionate, N-lauroyl sarcosine isopropyl ester and N,N,-diethyltoluamide. Other suitable fatty amides are disclosed in U.S. Pat. No. 6,872,401.

[0213] Other suitable oils include ethers. Suitable ethers include saturated and unsaturated fatty ethers of polyols and alkoxylated derivatives thereof. Exemplary ethers include C 4 -20 alkyl ether and di-C 8-30 Alkyl ethers. Suitable examples of these materials include PPG-14 butyl ether, PPG-15 stearyl ether, dioctyl ether, dodecyl octyl ether, and mixtures thereof.

[0214] Emulsifier

[0215] The personal care composition may include an emulsifier. When the composition is in the form of an emulsion or if an immiscible material is merged, the emulsifier will be particularly suitable. The personal care composition may include about 0.05%, 0.1%, 0.2%, 0.3%, 0.5% or 1% to about 20%, 10%, 5%, 3%, 2% or 1% of an emulsifier. The emulsifier may be nonionic, anionic or cationic. Non-limiting examples of emulsifiers are disclosed in U.S. Patent No. 3,755,560, U.S. Patent No. 4,421,769, and McCutcheon's Emulsifiers and Detergents, 2010, published by MC Publishing Company. Other suitable emulsifiers are further described in the International Cosmetic Ingredient Dictionary and Handbook of the Personal Care Products Council, 13th edition, 2006, under the functional category of "surfactant-emulsifier".

[0216] Suitable emulsifying ethers and esters include:

[0217] Ethers of polyethylene glycol and fatty alcohols, the fatty alcohols comprising saturated or unsaturated C 12-30The polyoxyethylene glycol comprises n oxyalkylene groups, wherein n=1 to 200 or alternatively an integer from 2 to 30 (e.g., 1 to 20 oxyalkylene groups). Specific examples include compounds with the INCI names Steareth-N, Beheneth-N, or Oleth-N. Suitable examples include compounds with the INCI names Steareth-8, Steareth-10, Steareth-16, Steareth-20, Ceteth-10, Laureth-4, Laureth-3, Trideceth-6, Ceteareth-5, Oleth-10, and Beheneth-10.

[0218] Esters of polyethylene glycol and fatty acids, the fatty acids comprising saturated or unsaturated C 12-30 Fatty acids (e.g., oleic acid, palmitic acid, stearic acid), and the polyethylene glycol includes n oxyalkylene groups, wherein n=an integer from 1 to 200, or 1 to 50 (e.g., 1 to 20 oxyethylene groups). Specific examples include compounds with the INCI names PEG-n Stearate or PEG-n Oleate). Suitable examples include polyethylene glycol-8 monostearate, polyethylene glycol-10 or polyethylene glycol-12 distearate.

[0219] Ethers of polyethylene glycol and glycosylated fatty alcohols, the fatty alcohols comprising C12-30 alcohols having 1 to 10 glycosyl groups, and the polyethylene glycol comprising n oxyalkylene groups, wherein n=an integer from 1 to 200 (e.g., 1 to 20 oxyethylene groups). A suitable example comprises polyoxyethylated (20OE) glucose distearate methyl ester.

[0220] Esters of polyethylene glycol and glycosylated fatty acids, the fatty acids comprising C having 1 to 10 glycosyl groups 12-30 The fatty acid and the polyethylene glycol include n oxyalkylene groups, wherein n=an integer from 1 to 200 (eg, 1 to 20 oxyethylene groups).

[0221] C 12-30 Ethers of alcohols and glycerol or polyglycerol - suitable examples include polyglycerol-3-cetyl ether, such as Chimexane NL from Chimex, esters of C12-30 fatty acids and glycerol or polyethylene glycol - include esters comprising 1 to 10 glycerol groups. Specific examples include hexaglyceryl monostearate, diglyceryl distearate, tetraglyceryl tristearate, decaglyceryl decastearate, diglyceryl monostearate, hexaglyceryl tristearate, decaglyceryl pentastearate, esters of glycerol with palmitic acid and stearic acid, and glyceryl monobehenate and glyceryl dibehenate.

[0222] Oxyalkylene-modified C 12-30 Ethers of alcohols and glycerol or polyglycerols.

[0223] C including and with sucrose or glucose 12-30 Ethers of fatty alcohols - Suitable examples include those with the INCI name C 12-18 Alkyl glucoside, C 12-20 Compounds of alkyl glucoside (e.g. Montanov L from Seppic), cetearyl glucoside (e.g. cetearyl alcohol mixture under the reference Montanov 68 from Seppic), myristyl glucoside (e.g. mixture with myristyl alcohol under the reference Montanov 14 from Seppic) or cetearyl glucoside (e.g. Tegocare CG 90 from Evonik Goldschmidt).

[0224] Sucrose and C 12-30 Esters of fatty acids - Specific examples include sucrose distearate or sucrose tristearate, sucrose cocoate, sucrose dilaurate, sucrose distearate, sucrose hexaerucate, sucrose hexapalmitate, sucrose laurate, sucrose mortierellate, sucrose myristate, sucrose oleate, sucrose palmitate, sucrose pentaerucate, sucrose polybehenate, sucrose polycottonate, sucrose polylaurate, sucrose polylinoleate, sucrose polyoleate, sucrose polypalmitate, sucrose polysoylate, sucrose polystearate, sucrose ricinoleate, sucrose stearate, sucrose tetraisostearate, and sucrose trilaurate. Suitable examples include mixtures of esters (monoesters and polyesters) of stearic acid and sucrose, sold as Crodesta F110 by Croda.

[0225] Pentaerythritol and C 12-30 Esters of fatty acids - Specific examples include pentaerythritol tetrastearate.

[0226] Sorbitol and / or sorbitol and C 12-30 Esters of fatty acids - specific examples include sorbitan monostearate, sorbitan tristearate or sorbitan laurate, such as Span 20 from Uniqema,

[0227] Sorbitol and / or ethers of sorbitol and alkoxylated sorbitol - suitable examples include sorbitol-8 beeswax or sorbitol-20 beeswax from Nikko Chemical.

[0228] Ethers of polyethylene glycol and cholesterol - specific examples include choleth-3, choleth-10 (such as Emalex CS-10 from Nihon Emulsion Company), choleth-15 (such as Emalex CS-15 from Nihon Emulsion Company), or choleth-20 (such as Emalex CS-20 from Nihon Emulsion Company).

[0229] C 12-30 Esters of fatty acids and sorbitan alkoxylated ethers and / or suitable examples include polysorbate-60, polysorbate-61, sorbitan-3 isostearate, polyoxyethylated 4OE sorbitan monostearate, and polyoxyethylated 20OE sorbitan tristearate.

[0230] Linear or branched silicone emulsifiers may also be used. Particularly useful polyether-modified silicones include KF-6011, KF-6012, KF-6013, KF-6015, KF-6015, KF-6017, KF-6043, KF-6028, and KF-6038 from Shin-Etsu Chemical Co., Ltd. Also particularly useful are polyglycerolated linear or branched silicone emulsifiers from Shin-Etsu Chemical Co., Ltd., including KF-6100, KF-6104, and KF-6105. Exemplary materials include materials with the following International Nomenclature of Cosmetic Ingredients (INCI) names: Bis-Butyl Dimethicone Polyglyceryl-3; Bis-PEG / PPG-14 / 14 Dimethicone; Bis-Butyl Dimethicone Polyglyceryl-3; Bis-Isobutyl PEG / PPG-10 / 7 Dimethicone Copolymer; Bis-PEG / PPG-18 / 6 Dimethicone; Bis-PEG / PPG-20 / 20 Dimethicone; Bis-PEG / PPG-16 / 16 PEG / PPG-16 / 16 Dimethicone; Bis-(PPG-7 Undecyl)-1,1-Dimethicone Pareth-21)-Dimethicone; Dimethicone PEG-7 Cetyl Acetate; Cetyl PEG-8 Dimethicone; Cetyl PEG / PPG-15 / 16 Butyl Ether Dimethicone; Cetyl PEG / PPG-15 / 15 Butyl Ether Dimethicone; Cetyl PEG / PPG-7 / 3 Dimethicone; Cetyl PEG / PPG-10 / 1 Dimethicone; Dimethicone PEG-15 Acetate; Dimethicone PEG-7 Cocoate; Dimethicone PEG-7 Phosphate; Dimethicone Siloxane PEG-10 Phosphate; Dimethicone PEG / PPG-7 / 4 Phosphate; Dimethicone PEG / PPG-12 / 4 Phosphate; Dimethicone PEG-7 Undecylenate; Dimethicone PEG-10 Lauryl Phosphate; Isopolyglyceryl-3 Dimethicone; Isopolyglyceryl-3 Dimethiconol; Isostearyl Carboxydecyl PEG-8 Dimethicone; Methicone PEG-10 Lauryl Phosphate; Lauryl PEG-8 Dimethicone; Lauryl PEG-10 Methyl Ether Dimethicone; Lauryl PEG / PPG-18 / 18 polymethicone; PEG-6 methyl ether polydimethicone; PEG-7 methyl ether polydimethicone; PEG-9 methyl ether polydimethicone; PEG-10 methyl ether polydimethicone; PEG-11 methyl ether polydimethicone; PEG-11 methyl ether polydimethicone; PEG-32 methyl ether polydimethicone; PEG-PEG / PPG-28 / 21 acetate polydimethicone; PEG / PPG-22 / 22 butyl ether polydimethicone; PEG / PPG-23 / 23 butyl ether polydimethicone;PEG / PPG-24 / 18 butyl ether dimethicone; PEG / PPG-3 / 10 dimethicone; PEG / PPG-4 / 12 dimethicone; PEG / PPG-6 / 11 dimethicone; PEG / PPG-8 / 14 dimethicone; PEG / PPG-12 / 16 dimethicone; PEG / PPG-12 / 18 dimethicone; PEG / PPG-14 / 4 dimethicone; PEG / PPG-15 / 5 dimethicone; PEG / PPG-15 / 15 dimethicone; PEG / PPG-16 / 2 dimethicone; PEG / PPG-16 / 8 dimethicone; PEG / PPG-17 / 18 dimethicone; PEG / PPG-18 / 12 dimethicone; PEG / PPG-19 / 19 dimethicone dimethicone; PEG / PPG-20 / 6 dimethicone; PEG / PPG-20 / 15 dimethicone; PEG / PPG-20 / 20 dimethicone; PEG / PPG-20 / 29 dimethicone; PEG / PPG-22 / 23 dimethicone; PEG / PPG-22 / 24 dimethicone; PEG / PPG-25 / 25 dimethicone; PEG / PPG-27 / 27 dimethicone; PEG / PPG-30 / 10 dimethicone; PEG / PPG-10 / 3 oleyl dimethicone; PEG-8 trisiloxane; polyglyceryl-3 polydimethylsiloxyethyl dimethicone; PPG-12 butyl ether dimethicone; silicone quaternium-17; TEA-dimethicone PEG-7 phosphate; and mixtures thereof. ;

[0231] Emulsifiers also include emulsifying silicone elastomers. Suitable emulsifying silicone elastomers may include at least one polyalkyl ether or polyglycerolated unit. These crosslinked elastomers may also be co-modified to include alkyl substituents. Suitable formation techniques are described in U.S. Pat. Nos. 5,236,986; 5,412,004; 5,837,793; and 5,811,487. Polyoxylated emulsified silicone elastomers that can be used in at least one embodiment of the present disclosure include those sold by Shin-Etsu Silicone Corporation under the following names: KSG-21, KSG-20, KSG-30, KSG-31, KSG-32, KSG-33; KSG-210 (dimethicone / PEG-10 / 15 crosspolymer dispersed in dimethicone); KSG-310 (PEG-15 lauryl dimethicone crosspolymer); KSG-320 (PEG-15 lauryl dimethicone crosspolymer dispersed in isododecane); KSG-330 (PEG-15 lauryl dimethicone crosspolymer dispersed in triethylhexanoin), KSG-340 (PEG-10 lauryl dimethicone crosspolymer and PEG-15 lauryl dimethicone crosspolymer). Other silicone emulsified elastomers are available from Dow Corning. TM Provided are PEG-12 dimethicone crosspolymers (DC 9010 and 9011). Other suitable silicone emulsifiers sold by Dow Corning include DC9010 and DC9011.

[0232] Polyglyceryl emulsified silicone elastomers are disclosed in PCT / WO 2004 / 024798. Such elastomers include Shin-Etsu's KSG series, such as KSG-710 (dimethicone / polyglyceryl-3 crosspolymer dispersed in dimethicone); or lauryl dimethicone / polyglyceryl-3 crosspolymer dispersed in various solvents, such as isododecane, dimethicone, triethylhexanoin, KSG-810, KSG-820, KSG-830 or KSG-840 available from Shin-Etsu Chemical Co., Ltd.

[0233] Another suitable cross-linked silicone elastomer emulsifier is dimethicone / PEG-10 / 15 crosspolymer, which has excellent aesthetic properties due to its elastomeric backbone, but also has excellent emulsifying properties. Additional examples of cross-linked organosiloxane emulsifiers include, but are not limited to, dimethicone / dimethicone PEG / PPG 15 crosspolymer; dimethicone PEG-10 crosspolymer; dimethicone PEG-10 / 15 crosspolymer; dimethicone PEG-15 crosspolymer; dimethicone polyglyceryl-3 crosspolymer; dimethicone PPG-20 crosspolymer; lauryl dimethicone PEG-15 crosspolymer; lauryl dimethicone polyglyceryl-3 crosspolymer; PEG-8 dimethicone polysorbate-20 crosspolymer; PEG-10 dimethicone / vinyl dimethicone crosspolymer; PEG-10 lauryl dimethicone crosspolymer; PEG-15 / lauryl dimethicone crosspolymer; PEG-15 lauryl laurylsiloxyethyl crosspolymer; and mixtures thereof.

[0234] It should be recognized that the silicone elastomer can be pre-swollen with a solvent. For the pre-swollen expanded elastomer, the weight percentages recited for the emulsifier used (i.e., from about 0.05% to about 20%, from about 0.1% to about 10%, from about 0.5% to about 5%, or from about 1% to about 3% emulsifier) ​​are based only on the elastomer alone (i.e., excluding the weight of the solvent).

[0235] Structuring agent

[0236] The personal care composition can include a structurant. Structurants can be used to increase viscosity, thicken, solidify or provide a solid or crystalline structure for the personal care composition. Structurants can be used to suspend or disperse abrasive particles. Structurants are usually grouped based on solubility, dispersibility or phase compatibility. Examples of aqueous or water structurants include polymeric agents, natural or synthetic gums, polysaccharides, etc. In one embodiment, by weight of the composition, the composition can include about 0.0001%, 0.001%, 0.01%, 0.05%, 0.1%, 0.5%, 1%, 2%, 3%, 5% to about 25%, 20%, 10%, 7%, 5%, 4% or 2% of one or more structurants.

[0237] Polysaccharides and gums can be used as aqueous thickeners. Examples of such polysaccharides and gums include materials of natural origin, such as agar, agarose, Alcaligenes polysaccharide, seaweed, alginic acid, gum arabic, pullulan, chitin, dextran, cassia gum, cellulose gum, gelatin, gellan gum, hyaluronic acid, hydroxyethylcellulose, methylcellulose, ethylcellulose, pectin, sclerotium gum, xanthan gum, pectin, trehalose, gelatin, ammonium alginate, calcium alginate, calcium carrageenan, carnitine, carrageenan, guar gum, guar hydroxypropyl triammonium chloride, hyaluronic acid, hydroxypropyl chitosan, hydroxypropyl guar gum, karaya gum, kelp, locust bean gum, natto gum, potassium alginate, potassium carrageenan, propylene glycol alginate, sodium carboxymethyl dextran, sodium carrageenan, tragacanth gum, and mixtures thereof. Suitable polysaccharides include alkyl hydroxyalkyl cellulose ethers, such as cetyl hydroxyethyl cellulose, which is the ether of cetyl alcohol and hydroxyethyl cellulose. This material is available from Ashland Aqualon Functional Ingredients under the trade name Other useful polysaccharides include scleroglucans, which comprise a linear chain of (1-3) linked glucose units, wherein every three units have (1-6) linked glucoses, a commercially available example of which is Clearogel from MMP GmbH. TM CS11.

[0238] Classes of suitable polymeric structurants include, but are not limited to, carboxylic acid polymers, polyacrylamide polymers, sulfonated polymers, high molecular weight polyethylene glycols or polyglycerols, copolymers thereof, hydrophobically modified derivatives thereof, and mixtures thereof.

[0239] Carboxylic acid polymers include carbomers. These polymers are crosslinked compounds containing one or more monomers derived from acrylic acid, substituted acrylic acid, and salts and esters of these acrylic acid and substituted acrylic acid, wherein the crosslinker contains two or more carbon-carbon double bonds and is derived from a polyol. Suitable materials include 900 series (e.g., Noveon, Inc. 945, 940, 950, 954, 980, 951 and 981) and Ultrez series (for example, Ultrez 10 polymer, Ultrez 20 polymer and Other suitable carboxylic acid polymer reagents include Co10-30 alkyl acrylates with acrylic acid, methacrylic acid or their short chains (i.e., C 1 -4 alcohol) esters, wherein the crosslinking agent is an allyl ether of sucrose or pentaerythritol. These copolymers are called acrylate / C 10-30 Alkyl acrylate crosspolymer and is available from Nouyon AG as 1342, 1382、PEMULEN TM TR-1 and PEMULEN TM A form of TR-2 is commercially available.

[0240] Sulfonated polymers include polymers and copolymers containing 2-acrylamido-2-methylpropane sulfonic acid (i.e., AMPS or acryloyldimethyl taurate) and its salts. Exemplary AMPS structurants include sodium acrylate / sodium acryloyldimethyl taurate copolymers, which can be used as EG and EPG, or Hydroxyethyl Acrylate / Sodium Acryloyldimethyl Taurate Copolymer, is available as NS, FL and I-NS100 is available from Seppic Corporation (Fairfield, NJ). Another suitable sulfonated polymer is sodium polyacryloyldimethyl taurate, available from Seppic Corporation (Fairfield, NJ) as Other suitable sulfonated polymers include those available from Rohm and Haas Company, Inc. as Acudyne TM Acrylamide / sodium acryloyldimethyltaurate / acrylic acid copolymer obtained from SCP; available from Seppic as Acrylamide / sodium acryloyldimethyltaurate copolymer obtained from 600; available from Clariant International Ltd. as Ammonium acryloyldimethyltaurate / beheneth-25 methacrylate crosspolymer obtained from BLV; available from Clariant International GmbH as Ammonium acryloyldimethyltaurate / carboxyethyl acrylate crosspolymer obtained from TAC; available from Clariant International GmbH as ammonium acryloyldimethyltaurate / vinyl pyrrolidone copolymer available from AVC; dimethylacrylamide / sodium acryloyldimethyltaurate crosspolymer available from Toho Chemical Industry Co., Ltd. as SUpolymer G-1; and dimethylacrylamide / sodium acryloyldimethyltaurate crosspolymer available from Seppic Corporation as SepinovTM Sodium acrylate / acryloyldimethyltaurate / dimethylacrylamide crosspolymer available from P88; and available from Clariant International GmbH as Sodium Acryloyldimethyl Taurate / VP Crosspolymer from AVS. Additional sulfonated structurants are described in U.S. Patent Application Publication Nos. 2007 / 0140993 (identified as a gelling agent in the form of a copolymer of acryloyldimethyl taurate or a salt thereof) and 2006 / 0147396A1 (identified as a "polymer containing at least one sulfonic functional monomer").

[0241] Acrylamide polymers and copolymers include those from Seppic Corporation (Fairfield, NJ). 305, which is designated as "polyacrylamide and isoparaffin and laureth-7" by the Personal Care Products Council's International Cosmetic Ingredient Dictionary and Handbook, 13th edition, 2010. Other polyacrylamide polymers include multi-block copolymers of acrylamide and substituted acrylamides with acrylic acid and substituted acrylic acid. Commercially available examples of these multi-block copolymers include Lipo Chemicals, Inc. (Patterson, NJ) and SR150H, SS500V, SS500W, SSSA100H.

[0242] High molecular weight polyalkylene glycols or polyglycerols can be used as structuring agents. Suitable materials include polyethylene glycol (PEG) derivatives and polypropylene glycol (PPG) derivatives having a degree of polymerization of n. n can be from 50 to 200,000. Other suitable materials are polyglycerols having repeating glycerol moieties, wherein the number of repeating moieties ranges from about 15 to about 200 or from about 20 to about 100. Examples of suitable polyglycerols include those with the INCI names polyglyceryl-20, polyglyceryl-40, and the like.

[0243] The example of oil structurant comprises silicone and organic base material.The suitable range of oil structurant is about 0.01%, 0.05%, 0.1%, 0.5%, 1%, 2.5%, 5% or 10% to about 30%, 25%, 20%, 15%, 10% or 5%.Suitable oil phase structurant can be based on silicone, such as silicone elastomer, silicone glue, silicone wax, the linear silicone that its polymerization degree allows silicone to increase oil phase viscosity.The example of silicone structurant includes but is not limited to silicone elastomer, silicone glue and silicone wax.

[0244] Silicone elastomers suitable for the compositions of the present disclosure include those formed by reacting SiH-containing diorganosiloxanes and organopolysiloxanes or α-ω dienes in the presence of a platinum metal catalyst by addition reaction curing. Such elastomers may also be formed by other reaction methods, such as condensation curing of organopolysiloxane compositions by dehydrogenation reaction between hydroxyl-terminated diorganopolysiloxanes and SiH-containing diorganopolysiloxanes or αω dienes in the presence of an organotin compound; or by condensation curing of organopolysiloxane compositions using a condensation reaction between hydroxyl-terminated diorganopolysiloxanes and hydrolyzable organosiloxanes in the presence of an organotin compound or a titanate; peroxide curing organopolysiloxane compositions, which are thermally cured in the presence of an organic peroxide catalyst. Crosslinked organopolysiloxane elastomers useful in the present disclosure and methods of making the same are further described in U.S. Pat. Nos. 4,970,252, 5,760,116 and 5,654,362, 6,524,598 and 6,696,049. Silicone elastomers are particularly desirable for incorporation into the compositions of the present disclosure because they provide an excellent "feel" to the composition, are very stable in cosmetic formulations, and are relatively inexpensive.

[0245] Suitable silicone elastomers may be in powder form, or dispersed or dissolved in a solvent, such as a volatile or non-volatile silicone, or a silicone compatible carrier, such as a hydrocarbon or ester. Examples of silicone elastomer powders include vinyl dimethicone / methylsiloxane silsesquioxane crosspolymers, such as KSP-100, KSP-101, KSP-102, KSP-103, KSP-104, KSP-105 available from Shin-Etsu Chemical Co., Ltd.; hybrid silicone powders containing fluoroalkyl groups, such as KSP-200 available from Shin-Etsu Chemical Co., Ltd., which is a fluoro-silicone elastomer; and hybrid silicone powders containing phenyl groups, such as KSP-300 available from Shin-Etsu Chemical Co., Ltd., which is a phenyl-substituted silicone elastomer; and DC 9506 available from Dow Corning.

[0246] Examples of silicone elastomers dispersed in a silicone compatible carrier include dimethicone / vinyl dimethicone crosspolymers supplied by various suppliers, including those supplied by Dow Corning under the trade names DC9040 or DC9041, Momentive under the trade name SFE 839, or Shin-Etsu Silicones under the trade names KSG-15, 16, 18. The INCI name for KSG-15 is Cyclopentasiloxane (and) Dimethicone / Vinyl Dimethicone Crosspolymer. The INCI name for KSG-18 is Diphenylsiloxy Phenyl Trimethicone (and) Dimethicone / Phenyl Vinyl Dimethicone Crosspolymer. Silicone elastomers can also be purchased from Grant Industries under the Gransil trademark. Other suitable silicone elastomers have long chain alkyl substitutions such as lauryl dimethicone / vinyl dimethicone crosspolymers supplied by Shin-Etsu Chemical Co., Ltd. under the trade names KSG-31, KSG-32, KSG-41, KSG-42, KSG-43, and KSG-44.

[0247] Silicone gel is another oil phase structurant. The viscosity of silicone gel at 25°C is generally between about 500,000 and 100 million cst, about 600,000 to 20 million, about 600,000 to 12 million cst. The silicone gel used in the composition includes but is not limited to those represented by the general formula, wherein:

[0248]

[0249] R 1 To R 10 Each is independently hydrogen, an alkyl group, an aryl group or an aralkyl group having 1 to 30 carbon atoms; and X is H, OH or a C1-30 alkyl group or a vinyl group. x, y or z may be zero, provided that (x+y+z)≧1.

[0250] Such silicone glue can be purchased in pure form from various silicone manufacturers including Wacker Chemical Company or Dow Corning Company, etc. Silicone glue includes silicone glue sold by Wacker-Belsil Company under the trade name CM3092, Wacker-Belsil 1000 or Wacker-Belsil DM 3096. Silicone glue with X being OH, also known as polydimethylsiloxane alcohol, can be obtained from Dow Corning Company under the trade name 1-1254Fluid, 2-9023Fluid and 2-9026Fluid. Silicone glue can also be purchased in the form of a solution or dispersion in a silicone-compatible carrier (such as volatile or non-volatile silicone). Examples of such mixtures can be purchased from Bamet Silicones Company under the trade name HL-88, INCI name polydimethylsiloxane. Another example is a mixture of dimethiconol and a volatile or nonvolatile silicone available from Dow Corning under the trade names 1401 Fluid, 1403 Fluid, and 1501 Fluid.

[0251] Another type of oil phase structurant includes silicone wax. Silicone wax can be referred to as alkyl silicone wax, which is semi-solid or solid at room temperature. The term "alkyl silicone wax" means a polydimethylsiloxane with a substituted long-chain alkyl group (such as C16 to 30), which imparts semi-solid or solid properties to silicone. Examples of such silicone waxes include stearyl polydimethylsiloxane, which can be purchased from Evonik High Schmidt Co., Ltd. under the trade name Abil Wax 9800, or from Dow Corning under the trade name 2503. Another example is bis-stearoyl polydimethylsiloxane (which can be purchased from Gransil Industries under the trade name Gransil A-18), behenyl polydimethylsiloxane or behenoxy polydimethylsiloxane.

[0252] Other suitable structuring agents include polyamides and silicone-polyamide copolymers. Suitable silicone-polyamide copolymers are disclosed in U.S. Patent Application Publication No. 2004 / 0170586. A specific example of such a copolymer is a nylon 611 / polydimethylsiloxane copolymer supplied by Dow Corning under the trade name Dow Corning 2-8178. Also suitable are polyamides, such as those available from Arizona Chemical Company under the trade name Uniclear TM and Include A200V or A2614V (INCI name: ethylenediamine / hydrogenated dimer dioleate copolymer / bis-di-C14-18 alkylamide) commercially available polyamide; AF1900V and PA1200V (INCI name: Polyamide-3); C75V (INCI name: BISTEARYL ETHYLENEDIAMINE / NEOPENTYL GLYCOL / STEARYL HYDROGENATED DIMER DIMER DILINOLEATE COPOLYMER); PE400V (INCI name: polyamide-6); WF 1500V (INCI name: Polyamide-4); or Uniclear TM 100VG (INCI name: ethylenediamine / stearoyl dimer dimer dimer linoleate copolymer; or ethylenediamine / stearoyl dimer dital acid copolymer).

[0253] Other oil phase structurants may include one or more natural or synthetic waxes, such as animal wax, vegetable wax or mineral wax. Typically, the melting point of such waxes is in the range of about 25°C to 125°C, and alternatively about 30°C to about 100°C. Non-limiting examples of suitable waxes include silicone waxes, fatty esters, such as cetyl esters and / or stearyl esters, gum arabic, beeswax, ozokerite, flower wax, citrus wax, carnauba wax, jojoba wax, Japan wax, polyethylene, microcrystalline, rice bran, lanolin wax, mink, montan wax, bayberry, candelilla, ozokerite, palm kernel wax, paraffin, avocado wax, apple wax, shellac wax, clary sage wax, waste grain wax, candelilla wax, grape wax, its polyalkylene glycol derivatives (for example PEG6-20 beeswax or PEG-12 carnauba wax) and a mixture of any wax in the above waxes. In one embodiment, the wax is a polyethylene wax, and alternatively a polyethylene wax having a melting point below 120°C, alternatively below 95°C and alternatively below 85°C.

[0254] Non-limiting examples of suitable silicone waxes are disclosed in U.S. Pat. Nos. 5,413,781 and 5,725,845, and further include alkyl methyl polysiloxane, C 10 -C 60 Alkyl polydimethylsiloxane and mixtures thereof. Alternatively, the silicone wax may be C 16 -C 28 Alkyl Dimethicone Wax. Other suitable silicone waxes include, but are not limited to, stearoxy dimethicone, behenoxy dimethicone, stearyl dimethicone, cetearyl dimethicone, cetyl dimethicone, and mixtures thereof.

[0255] Other structurants are natural or synthetic montmorillonite minerals, such as hectorite, bentonite and quaternized derivatives thereof, which are obtained by reacting the minerals with quaternary ammonium compounds (eg stearalkonium bentonite and stearalkonium hectorite).

[0256] Other structuring agents are silicon dioxide, silicates, silicon dioxide silylates and alkali metal or alkaline earth metal derivatives thereof. These silicon dioxides and silicates are usually present in particulate form and include silicon dioxide, silicon dioxide silylates, magnesium aluminum silicates and the like.

[0257] Additional Ingredients

[0258] The personal care composition may include one or more additional components to provide effective and / or consumer desired products. For example, the composition may include other active substances or agents. For example, suitable optional active substances and agents may include active substances or agents selected from the group consisting of: glucosamine, vitamins, oil control agents, phytosterols, hexamidine compounds, firming agents, anti-wrinkle active substances, anti-atrophy active substances, flavonoids, N-acyl amino acid compounds, retinoids, peptides, particulate materials, UV active substances, light stabilizers, anti-cellulite agents, peeling active substances, anti-acne active substances, antioxidants, free radical scavengers, conditioners, anti-inflammatory agents, tanning active substances, skin lightening agents, plant extracts, antimicrobial active substances, antifungal active substances, antibacterial active substances, antiperspirant active substances, sensory agents, preservatives, antidandruff active substances, substantial polymers, washing surfactants and combinations thereof. Suitable non-limiting examples are discussed in more detail below.

[0259] 1. Glycosamine

[0260] The personal care compositions of the present disclosure may include sugar amines, also known as amino sugars. Sugar amine compounds useful in the present disclosure may include those described in PCT Publication WO 02 / 076423 and U.S. Patent No. 6,159,485. In one embodiment, the composition may include from about 0.001%, 0.01%, 0.05%, 0.1%, 0.5% or 1% to about 10%, 7%, 5% or 2% of one or more sugar amines by weight of the composition.

[0261] Glycosamines can be synthetic or natural in origin and can be used as pure compounds or mixtures of compounds (e.g., extracts of natural origin or mixtures of synthetic materials). For example, glucosamine is commonly found in many shellfish and can also be derived from fungal sources. As used herein, "glycosamine" includes isomers and tautomers thereof and salts thereof (e.g., HCl salts), and is commercially available from Sigma Chemical Co.

[0262] Examples of sugar amines useful herein include glucosamine, N-acetylglucosamine, mannosamine, N-acetylmannosamine, galactosamine, N-acetylgalactosamine, isomers thereof (e.g., stereoisomers) and salts thereof (e.g., HCl salts). Glucosamine, specifically D-glucosamine and N-acetylglucosamine, especially N-acetyl-D-glucosamine, is preferably used herein.

[0263] 2. Vitamins

[0264] In some embodiments, the composition may include from about 0.001%, 0.01%, 0.05%, 0.1%, 0.5%, or 1% to about 10%, 7%, 5%, or 2% vitamins by weight of the composition. "Vitamins" means vitamins, provitamins, and salts, isomers, and derivatives thereof. Non-limiting examples of suitable vitamins include: vitamin B compounds (including B1 compounds, B2 compounds, B3 compounds, B5 compounds, such as panthenol or "pro-B5", pantothenic acid, panthenyl; B6 compounds, such as pyridoxine, pyridoxal, pyridoxamine; carnitine, thiamine, riboflavin); vitamin D compounds; vitamin K compounds; vitamin E compounds, or tocopherols, including tocopherol sorbate, tocopherol acetate, other tocopherol esters and tocopherol compounds; vitamin C compounds, including ascorbic acid, ascorbic acid esters of fatty acids and ascorbic acid derivatives, for example, ascorbyl phosphates, such as magnesium ascorbyl phosphate and sodium ascorbyl phosphate, ascorbyl glucoside and ascorbyl sorbate; and vitamin F compounds, such as saturated and / or unsaturated fatty acids.

[0265] In some embodiments, the personal care composition does not include any vitamin A compounds, or all natural and / or synthetic analogs of vitamin A, including retinoids, retinol, retinyl acetate, retinyl palmitate, retinoic acid, retinal, retinyl propionate, carotenoids (provitamin A), or other compounds that have the biological activity of vitamin A.

[0266] In certain embodiments, the personal care compositions include a vitamin B3 compound.

[0267] Vitamin B3 compounds are particularly useful for regulating skin conditions, as described in U.S. Pat. No. 5,939,082, the disclosure of which is incorporated herein by reference in its entirety. In one embodiment, the composition may include from about 0.001%, 0.01%, 0.05%, 0.1%, 0.5% or 1% to about 50%, 20%, 10%, 7% or 5% of a vitamin B3 compound by weight of the composition.

[0268] As used herein, "vitamin B3 compound" means a compound having the following chemical formula:

[0269]

[0270] Where R is—CONH 2 (ie, nicotinamide), -COOH (ie, nicotinic acid) or -CH2OH (ie, nicotinyl alcohol); derivatives thereof; and salts of any of the foregoing.

[0271] Exemplary derivatives of the foregoing vitamin B3 compounds include nicotinic acid esters, including non-vasodilating esters of nicotinic acid (e.g., tocopheryl nicotinate, myristyl nicotinate), nicotinyl amino acids, nicotinyl alcohol esters of carboxylic acids, nicotinic acid N-oxide, and niacinamide N-oxide.

[0272] In certain embodiments, the personal care composition includes a vitamin C compound. In some embodiments, the vitamin C compound is a vitamin C derivative.

[0273] In some embodiments, the vitamin C derivative is ascorbyl palmitate having the formula:

[0274] Derivatives thereof; and salts of any of the foregoing.

[0275] In some embodiments, the vitamin C derivative is magnesium ascorbyl phosphate having the formula:

[0276] Derivatives thereof; and salts of any of the foregoing.

[0277] In some embodiments, the vitamin C derivative is ethyl ascorbic acid having the formula:

[0278] Derivatives thereof; and salts of any of the foregoing.

[0279] 3. Phytosterols

[0280] The personal care composition can include phytosterols. For example, one or more phytosterols can be selected from the group consisting of: beta-sitosterol, campesterol, brassicasterol, A5-avenasterol, lupeol, α-spinasterol, stigmasterol, derivatives, analogs, and combinations thereof. In certain embodiments, the phytosterol is selected from the group consisting of: beta-sitosterol, campesterol, brassicasterol, stigmasterol, derivatives, and combinations thereof. In selected embodiments, the phytosterol is stigmasterol.

[0281] Phytosterol can be synthetic or natural in source, and can be used as pure compound or mixture of compound (for example, extract of natural origin) basically. Phytosterol is usually present in the unsaponifiable part of vegetable oil and fat, and can be obtained as free sterol, acetylated derivative, sterol ester, ethoxylation or glycoside derivative. More preferably, phytosterol is free sterol. As used herein, " phytosterol " comprises its isomer and tautomer, and can be commercially available from Aldrich Chemical Company, Sigma Chemical Company and Cognis.

[0282] In one embodiment, the composition may include from about 0.0001%, 0.001%, 0.01%, 0.05%, 0.1%, 0.5% or 1% to about 25%, 20%, 10%, 7%, 5% or 3% of one or more phytosterols by weight of the composition.

[0283] 4. Hexamidine compounds

[0284] The personal care composition may contain a hexamidine compound, its salts and derivatives. As used herein, "hexamidine compound" means a compound having the following chemical formula:

[0285]

[0286] Where R 1 and R 2 is optionally an organic acid (eg, sulfonic acid, etc.).

[0287] In one embodiment, the composition may include from about 0.0001%, 0.001%, 0.01%, 0.05%, 0.1%, 0.5% or 1% to about 25%, 20%, 10%, 7%, 5% or 3% of one or more hexamidine compounds by weight of the composition.

[0288] As used herein, hexamidine derivatives include any isomers and tautomers of hexamidine compounds, including but not limited to organic acids and inorganic acids, such as sulfonic acids, carboxylic acids, etc. In selected embodiments, the hexamidine compound includes hexamidine diisothiocyanate, available from Laboratories Serobiologiques as HP100 was purchased commercially.

[0289] 5. Firming agent

[0290] Personal care compositions may include a firming agent.A firming agent is a compound capable of producing a firming effect on keratinous tissue, and typically the skin. Suitable firming agents may be chosen from vegetable or animal proteins and their hydrolysates, such as corn, rye, wheat, buckwheat, sesame, spelt, peas, beans, lentils, soybeans and lupins; polysaccharides of natural origin, including (i) polysaccharides, for example, in the form of starch, in particular from rice, corn, potato, cassava, peas, wheat, oats, etc., or in the form of carrageenan, alginates, agar, gelatin, cellulose polymers and pectins, advantageously as aqueous dispersions of gel microparticles, and (ii) latex composed of shellac, pine gum, dammar, elemi, copal, cellulose compounds and mixtures thereof; mixed silicates, including layered silicates, and in particular lapis lazuli; colloidal particles of inorganic fillers, such as colloidal particles of silica / alumina, such as those produced by WR Grace & Co. under the then trade name those sold; synthetic polymers such as polyurethane latex or acrylic / silicone latex, specifically those described in U.S. Patent Application Publication No. 2002 / 0131948, containing propylthio(polymethyl acrylate), propylthio(polymethyl methacrylate) and propylthio(polymethacrylic acid) grafted polydimethylsiloxane, propylthio(polyisobutyl methacrylate) and propylthio(polymethacrylic acid) grafted polymethylsiloxane (available from 3M under the trade names VS 80, VS 70 and L021); and mixtures thereof.

[0291] The personal care composition can include from about 0.0001%, 0.001%, 0.01%, 0.05%, 0.1%, 0.5% or 1% to about 30%, 25%, 20%, 10%, 7%, 5% or 3% of one or more firming agents by weight of the composition.

[0292] 6. Anti-wrinkle active substances / anti-atrophy active substances

[0293] The personal care composition of the present disclosure may include one or more anti-wrinkle actives or anti-atrophy actives. Exemplary anti-wrinkle / anti-atrophy actives suitable for the compositions of the present disclosure include dialkanoyl hydroxyproline compounds, hydroxy acids (e.g., glycolic acid, lactic acid, lactobionic acid), keto acids (e.g., pyruvic acid), phytic acid, lysophosphatidic acid, stilbenes, cinnamate, resveratrol, kinetin, zeatin, dimethylaminoethanol, peptides of natural origin (e.g., soy peptides) and sugar salts (e.g., gluconate Mn, gluconate Zn). In one embodiment, by weight of the composition, the composition may include from about 0.0001%, 0.001%, 0.01%, 0.05%, 0.1%, 0.5% or 1% to about 30%, 25%, 20%, 10%, 7%, 5% or 3% of one or more anti-wrinkle / anti-atrophy compounds.

[0294] Suitable dialkanoyl hydroxyproline compounds of the present disclosure may include those corresponding to the following chemical formula:

[0295]

[0296] Where R 1 It is H, X, C 1 -C 20 Straight or branched alkyl group,

[0297] X is a metal (Na, K, Li, Mg, Ca) or an amine (DEA, TEA);

[0298] R 2 It is C 1 -C 20 Straight or branched chain alkyl;

[0299] R 3 It is C 1 -C 20 Straight chain or branched chain alkyl.

[0300] Suitable derivatives include, but are not limited to, esters, such as fatty esters, including, but not limited to, tripalmitoyl hydroxyproline and dipalmitoyl acetyl hydroxyproline. One particularly useful compound is dipalmitoyl hydroxyproline. As used herein, dipalmitoyl hydroxyproline includes any isomers and tautomers thereof and is available from Seppic Corporation under the trade name Sepilift Commercially available. Additional discussion of dipalmitoyl hydroxyproline is provided in PCT Publication WO 93 / 23028. Preferably, the dipalmitoyl hydroxyproline is the triethanolamine salt of dipalmitoyl hydroxyproline, as discussed in U.S. Pat. No. 7,285,570.

[0301] 7. Flavonoids

[0302] The personal care compositions of the present disclosure may include flavonoid compounds. Flavonoids are widely disclosed in U.S. Pat. Nos. 5,686,082 and 5,686,367. Examples of flavonoids particularly suitable for the present disclosure are one or more flavones, one or more isoflavones, one or more coumarins, one or more chromones, one or more dicoumarols, one or more chromanones, one or more chromanols, isomers thereof (e.g., cis / trans isomers) and mixtures thereof.

[0303] Exemplary flavonoids include flavones and isoflavones, specifically daidzein (7,4'-dihydroxy isoflavone), genistein (5,7,4'-trihydroxy isoflavone), equol (7,4'-dihydroxy isoflavone), 5,7-dihydroxy-4'-methoxy isoflavone, soy isoflavones (mixture extracted from soybeans) and other plant sources of such mixtures (e.g., red clover), and mixtures thereof. Other exemplary materials include flavanones, such as hesperidin, hesperidin and mixtures thereof. Useful flavonoid compounds herein are commercially available from a variety of sources, such as Indofine Chemical Company, Inc., Steraloids, Inc., and Aldrich Co., Ltd.

[0304] In one embodiment, the composition may include from about 0.0001%, 0.001%, 0.01%, 0.05%, 0.1%, 0.5% or 1% to about 30%, 25%, 20%, 10%, 7%, 5% or 3% of one or more flavonoid compounds by weight of the composition.

[0305] 8. Microparticle materials

[0306] The personal care compositions of the present disclosure may include one or more additional particulate materials. Non-limiting examples of particulate materials that can be used in the present disclosure include colored and colorless pigments, interference pigments, inorganic powders, organic powders, composite powders, optical brightener particles, and combinations thereof. In one embodiment, the composition may include from about 0.0001%, 0.001%, 0.01%, 0.05%, 0.1%, 0.5%, 1% or 2% to about 50%, 25%, 20%, 10%, 7%, 5% or 3% of particulates by weight of the composition. There are no particular restrictions on the pigments, colorants, or filler powders used in the composition.

[0307] The microparticle materials useful herein may include, but are not limited to, bismuth oxychloride, sericite, mica, mica treated with barium sulfate or other materials, zeolite, kaolin, silica, boron nitride, lauroyl lysine, nylon, polyethylene, talc, styrene, polypropylene, polystyrene, ethylene / acrylic acid copolymers, polyurethane, alumina, silicone resins, barium sulfate, calcium carbonate, cellulose acetate, PTFE, polymethyl methacrylate, starch, modified starch such as aluminum starch octenyl succinate, silk, glass, and mixtures thereof. Suitable commercial examples of microparticles include, but are not limited to, polymer particles selected from polymethylsilsesquioxane resin microspheres, such as those comprising the following: commercially available from Maitu High-Tech Materials Co., Ltd. under the trade name materials sold as; microspheres of polymethyl methacrylate, such as Micropearl M305 from Seppic; spherical particles of cross-linked polydimethylsiloxane, particularly those sold as Dow Corning 9506 Cosmetic Powder by Dow Corning; spherical particles of polyamide, and more particularly nylon 12, such as Ato Chemical's 2002 series; polystyrene microspheres, such as those manufactured by Dyno Particles under the name those sold by Kobo under the name EA209; ethylene acrylate copolymer sold by Kobo; PTFE, polypropylene, aluminum starch octenyl succinate, such as Akzo Nobel under the name Those sold; microspheres of polyethylene, such as those sold by Equistar under the name FN510-00 and those sold under the name Micropoly by Presperse, Inc.; silicone resins, polymethylsilsesquioxane silicone polymers, and mixtures thereof. Suitable particulate materials include spherical powders having an average primary particle size of about 0.1 to about 75 microns or about 0.2 to about 30 microns.

[0308] Other suitable particulate materials include interference pigments. For the purposes of this specification, interference pigments are defined as thin plate-like layered particles having two or more layers of controlled thickness with different refractive indices that produce a characteristic reflected color by interference of light reflections from different layers of the plate-like particle, usually two layers but occasionally more. The most common example of an interference pigment is mica, with a layer of about 50-300 nm of TiO 2 , Fe 2 O 3 , silicon dioxide, tin oxide and / or Cr 2 O 3 Such pigments are usually pearlescent. Due to the large difference in the transparency of the pigment particles and the refractive index of the mica flakes and, for example, the titanium dioxide coating, pearlescent pigments reflect, refract and transmit light. Useful interference pigments are commercially available from various suppliers, such as Rona (Timiron TM and Dichrona TM ), Presperse (Flonac TM ), Englehard (Duochrome TM ), Kobo Corporation (KTZ Interfine and KTZ Interval), BASF (Reflecks TM) and Eckart (Prestige series). Suitable interference pigments can have a small particle size, wherein the average diameter of the individual particles is less than about 75 microns or less than about 50 microns in the longest direction.

[0309] Other particulate materials include pigments that can provide color to the personal care composition. Suitable pigments include inorganic pigments, organic pigments, and combinations thereof. Examples of such useful inorganic pigments include iron oxide, ammonium ferrocyanide, manganese violet, ultramarine blue, and chromium oxide. Organic pigments can include natural colorants and synthetic monomeric and polymeric colorants. An example is phthalocyanine blue and green pigments. Lakes, primary FD&C or D&C lakes, and blends thereof are also useful. Encapsulated soluble or insoluble dyes and other colorants are also useful. Inorganic white or colorless pigments that can be used in the present disclosure, such as TiO 2 , ZnO or ZrO 2 It is commercially available from a variety of sources. One example of a suitable particulate material comprises material available from American Cosmetic Company (TRONOX TiO2 series, SAT-T CR837, rutile TiO2). Suitable pigments include charged dispersions of titanium dioxide, as disclosed in US Pat. No. 5,997,887.

[0310] The primary average particle size of the colored or colorless pigment can be from about 10 nm, 15 nm or 20 nm to about 100,000 nm, 5,000 nm or 1000 nm. Mixtures of the same or different pigments having different particle sizes are also useful herein (e.g., mixing TiO2 having a primary particle size of about 100 nm to about 400 nm with a mixture of TiO2 and TiO3 having a primary particle size of about 100 nm to about 400 nm). 2 TiO with a primary particle size of about 10 nm to about 50 nm 2 combined).

[0311] The particulate material may be surface treated to provide additional stability and / or ease of formulation. Non-limiting examples of suitable coating materials include silicones, lecithin, amino acids, metal soaps, polyethylene, and collagen. These surface treatments may be hydrophobic or hydrophilic. Particularly useful hydrophobic pigment treatments include polysiloxane treatments such as those disclosed in U.S. Pat. No. 5,143,722.

[0312] 8.UV active substances (light protection filters)

[0313] The compositions of the present disclosure may contain UV active substances. As used herein, "UV active substances" or "photoprotective filters" include both sunscreens and physical sunscreens. Suitable UV active substances may be organic or inorganic. Suitable UV active substances are listed in the "sunscreen" functional category in the International Cosmetic Ingredient Dictionary and Handbook, 13th edition, 2010, of the Personal Care Product Council.

[0314] Suitable UV actives include dibenzoylmethane derivatives including 2-methyldibenzoylmethane, 4-methyldibenzoylmethane, 4-isopropyldibenzoylmethane, 4-tert-butyldibenzoylmethane, 2,4-dimethyldibenzoylmethane, 2,5-dimethyldibenzoylmethane, 4,4'-diisopropyldibenzoylmethane, 4,4'-dimethoxydibenzoylmethane, 4-tert-butyl-4'-methoxydibenzoylmethane (i.e. butyl methoxydibenzoylmethane or avobenzone) (available from DSM as 1789), 2-methyl-5-isopropyl-4'-methoxydibenzoylmethane, 2-methyl-5-tert-butyl-4'-methoxydibenzoylmethane, 2,4-dimethyl-4'-methoxydibenzoylmethane and 2,6-dimethyl-4-tert-butyl-4'-methoxydibenzoylmethane. Other suitable UV active materials include 2-ethylhexyl p-methoxycinnamate (available from DSM as MCX is commercially available), 2-hydroxy-4-methoxybenzophenone, benzophenone-3 (i.e., oxybenzone), octyl dimethyl p-aminobenzoic acid, digalloyl trioleate, 2,2-dihydroxy-4-methoxybenzophenone, ethyl-4-(bis(hydroxypropyl))aminobenzoate, 2-ethylhexyl-2-cyano-3,3-diphenylacrylate, 2-ethylhexyl-salicylate, glyceryl p-aminobenzoate, 3,3,5-trimethylcyclohexyl salicylate, methyl anthranilate, p-dimethylaminobenzoic acid or aminobenzoate, 2-ethyl p-dimethyl-amino-benzoate, 2-phenylbenzimidazole-5-sulfonic acid, 2-(p-dimethylaminophenyl)-5-sulfonic acid benzooxazole acid, octocrylene, zinc oxide, titanium dioxide, and mixtures of these compounds.

[0315] Particularly suitable UV actives for use in the compositions of the present disclosure are 2-ethylhexyl p-methoxycinnamate, 4-tert-butyl-4'-methoxydibenzoylmethane, 2-hydroxy-4-methoxybenzo-phenone, 2-phenylbenzimidazole-5-sulfonic acid, octocrylene, zinc oxide, titanium dioxide, and mixtures thereof.

[0316] Other suitable UV active materials include 4-methylbenzylidene camphor (available from DSM as 5000 or commercially available from Merck as Eusolex 6300); methylenedibenzotriazole tetramethylbutylphenol (i.e., bis-oxotriazole, available from BASF as M is commercially available); bis-ethylhexyloxyphenol methoxyphenol triazine (i.e., bemotrizinol, available from BASF as S is commercially available); disodium phenyl dibenzimidazole tetrasulfonate (i.e., bisdisulizoledisodium, available from Symrise as Neo AP commercially available); ethylhexyl triazone (available from BASF as T 150 is commercially available); drometrizole trisiloxane (sold as Mexoryl XL by L'Oreal); sodium dihydroxydimethoxydisulfobenzophenone (i.e., benzophenone-9, available from BASF as DS49 is commercially available); diethylamino hydroxybenzoyl hexyl benzoate (available from BASF as APlus commercially available); diethylhexyl butyramido triazone (i.e., Iscotrizinol, available from 3VSigma as HEB); polysilicone-15 (available from DSM as SLX is commercially available); and isopentyl p-methoxycinnamate (i.e., amiloride, available from Symrise as Neo E 1000 is commercially available).

[0317] 9. Light stabilizer

[0318] A suitable light stabilizer is α-cyanodiphenylacrylate, as disclosed in U.S. Pat. No. 7,713,519. α-Cyanodiphenylacrylate may have the general formula:

[0319]

[0320] Wherein one or both of R1 and R2 are independently straight or branched C1-30 alkoxy, and any non-alkoxy R1 or R2 group is hydrogen; and R3 is straight or branched C1-30 alkyl. Alternatively, one or both of R1 and R2 are independently C1-8 alkoxy, and any non-alkoxy R1 or R2 group is hydrogen; and R3 is straight or branched C2-20 alkyl. Alternatively, one or both of R1 and R2 are independently methoxy, and any non-methoxy R1 or R2 is hydrogen; and R3 is straight or branched C2-20 alkyl.

[0321] Suitable α-cyanodiphenylacrylates are ethylhexyl methoxyacrylate or 2-ethylhexyl 2-cyano-3-(4-methoxyphenyl)-3-phenylacrylate, wherein R1 is methoxy, R2 is hydrogen, and R3 is 2-ethylhexyl. This material is available from Hallstar Company under the trade name S1 obtained.

[0322] Another suitable light stabilizer comprises a diester or polyester of naphthalene dicarboxylic acid, as disclosed in U.S. Pat. Nos. 5,993,789, 6,113,931, 6,126,925, and 6,284,916. Suitable diesters or polyesters of naphthalene dicarboxylic acid may have the formula:

[0323]

[0324] Each R 1 is independently an alkyl group having 1 to 22 carbon atoms, or a group having the formula HO—R 2 —OH, or a diol having the formula HO—R 3 —(—O—R 2 —) m —OH polyethylene glycol, and wherein R 2 and R 3 The same or different groups are each an alkylene radical having 1 to 6 carbon atoms, linear or branched, wherein m and n are each 1 to about 100, 1 to about 10, or 2 to about 7. A suitable diester of naphthalene dicarboxylic acid is diethylhexyl 2,6-naphthalene dicarboxylate, available from Symrise Inc. as TQ obtained.

[0325] Another suitable light stabilizer is a 4-hydroxybenzylidene malonate derivative or a 4-hydroxycinnamate derivative. Such materials may have the following formula:

[0326]

[0327] Wherein A is a chromophore that absorbs UV radiation, including a divalent group or two monovalent groups, at least one of which has a carbonyl (C=O) functional group; R' is hydrogen, a straight chain or branched C 1 -C 8 Alkyl or linear or branched C 1 -C 8 Alkoxy; and R" is a straight chain or branched C 1 -C 8 Alkyl. Exemplary compounds include ethyl-α-cyano-3,5-dimethoxy-4-hydroxycinnamate, ethyl-α-acetyl-3,5-dimethoxy-4-hydroxycinnamate, isopropyl-α-acetyl-3,5-dimethoxy-4-hydroxycinnamate, isopentyl-α-acetyl-3,5-dimethoxy-4-hydroxycinnamate, 2-ethylhexyl-α-acetyl-3,5-dimethoxy-4-hydroxycinnamate, diethyl-3,5 -dimethoxy-4-hydroxybenzylidene malonate, di-(2-ethylhexyl)-3,5-dimethoxy-4-hydroxybenzylidene malonate, diisopentyl-3,5-dimethoxy-4-hydroxybenzylidene malonate, didodecyl-3,5-dimethoxy-4-hydroxybenzylidene malonate, dipalmitoyl-3,5-dimethoxy-4-hydroxybenzylidene malonate and diisopropyl-3,5-dimethoxy-4-hydroxybenzylidene malonate. Particularly suitable compounds are available from EMD Chemicals, Inc. under the trade name Diethylhexyl syringylidenemalonate (INCI name) obtained from ST has the following formula:

[0328]

[0329] Additional suitable 4-hydroxybenzylidene malonate derivatives or 4-hydroxycinnamate derivatives are disclosed in US Pat. No. 7,357,919 and US Patent Application Publication Nos. 2003 / 0108492A1 and US 2003 / 0157035A.

[0330] Another suitable light stabilizer is a 2-pyrrolidone-4-carboxylate compound. Suitable 2-pyrrolidone-4-carboxylate compounds may have the following formula:

[0331]

[0332] Where R 1 Is it a straight chain or branched chain C 1 -C 20 Alkyl, and R 2 Yes, it can contain C 5 -C 6 Straight or branched ring C1 -C 20 Alkyl, phenyl, benzyl or phenethyl. 1 and R 2 Exemplary groups include methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, n-octyl, 2-ethylhexyl, dodecyl, hexadecyl, cyclohexyl, and methylcyclohexyl. Specific examples of 2-pyrrolidone-4-carboxyl ester compounds are provided in U.S. Patent Application Publication No. 2010 / 0183529.

[0333] Other suitable light stabilizers include: silicon-containing s-triazines substituted with two aminobenzoate or aminobenzamide groups as described in U.S. Patent Application Publication No. 2008 / 0145324; fluorene derivatives as described in U.S. Patent Application Publication Nos. 2004 / 00579912, 2004 / 00579914, 200 / 00579916, and 2004 / 062726; piperidinol salts as described in U.S. Patent Application Publication No. 2005 / 0220727, including those sold by Ciba under the trade name tris(tetramethylhydroxypiperidinol) citrate sold as Tris(tetramethylhydroxypiperidinol) citrate as sold by Q; and arylalkyl amides and esters as described in U.S. Patent Application Publication No. 2008 / 0019930.

[0334] Other suitable light stabilizers are listed in the functional category of "Light Stabilizers" in the International Cosmetic Ingredient Dictionary and Handbook, 13th Edition, 2010, by the Personal Care Products Association of the United States.

[0335] In one embodiment, the personal care composition may include from about 0.0001%, 0.001%, 0.01%, 0.05%, 0.1%, 0.5%, or 1% to about 30%, 25%, 20%, 10%, 7%, or 5% of one or more suitable light stabilizers by weight of the composition. In certain embodiments, the personal care composition may include at least one light stabilizer and at least one UV active material. In a specific embodiment, the UV active material is a dibenzoylmethane derivative. In a specific embodiment, the UV active material is 4,4'-tert-butylmethoxydibenzoyl-methane (i.e., avobenzone).

[0336] 10. Antioxidants / Free Radical Scavengers

[0337] The personal care compositions of the present disclosure may include antioxidants / radical scavengers. In one embodiment, the composition may include from about 0.0001%, 0.001%, 0.01%, 0.05%, 0.1%, 0.5%, or 1% to about 30%, 25%, 20%, 10%, 7%, 5%, or 3% of one or more antioxidants / radical scavengers by weight of the composition.

[0338] Suitable antioxidants are listed in the functional category “Antioxidants” in the International Cosmetic Ingredient Dictionary and Handbook, 13th edition, 2010, by the Personal Care Products Association of the United States.

[0339] Suitable antioxidants include butylated hydroxytoluene (BHT) and butylated hydroxyanisole (BHA). BHT can be described by the following general formula:

[0340]

[0341] wherein X is OH or SH;

[0342] Y is selected from the group consisting of: H, OH, OR 5 、COOR 5 , alkyl, cycloalkyl, heteroalkyl, heterocycloalkyl, aromatic, heteroaromatic, carboxamide, sulfonamide, carbamate, urea, and trialkylsilyl;

[0343] R 1 , R 2 , R 3 , R 4 Selected from the group consisting of: alkyl, cycloalkyl, heteroalkyl, heterocycloalkyl, aromatic, heteroaromatic, OR 5 , carboxamide, sulfonamide, formyl, acyl, carboxyl, carboxylate, carbamate, urea, trialkylsilyl, hydroxyl, and hydrogen;

[0344] R 5 Selected from the group consisting of alkyl, cycloalkyl, heteroalkyl, heterocycloalkyl, aromatic, heteroaromatic, trialkylsilyl, acyl and hydrogen.

[0345] Other antioxidants / free radical scavengers may be used, such as ascorbic acid (vitamin C), tocopherol (vitamin E), tocopherol sorbate, tocopherol acetate, other esters of tocopherol, 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (available under the trade name Commercially available), amines (e.g., N,N-diethylhydroxylamine, amino-guanidine), nordihydroguaiaretic acid, bioflavonoids, amino acids, silymarin, sorbic acid and its salts, lipoic acid, olive extract, green tea extract, white tea extract, black tea extract, polyphenols such as proanthocyanidins in pine bark, carotenoids, curcuminoid compounds such as tetrahydrocurcumin, OCTA (L-2-oxo-4-thiazolidinecarboxylic acid), glutathione and grape skin / seed extract. Suitable antioxidants / radical scavengers can be selected from esters of tocopherol, such as tocopherol acetate.

[0346] In one embodiment, the personal care composition includes tocopherol sorbate. As used herein, "tocopherol sorbate" refers to the sorbate of tocopherol, a detailed description of which can be found in issued U.S. Patent No. 5,922,758. In one embodiment, by weight of the composition, the composition can include about 0.0001%, 0.001%, 0.01%, 0.05%, 0.1%, 0.5% or 1% to about 50%, 25%, 20%, 10%, 7% or 5% tocopherol sorbate.

[0347] 11. Plant Extracts

[0348] The personal care composition of the present disclosure may include plant extracts. In one embodiment, the composition may include about 0.0001%, 0.0005%, 0.001%, 0.01%, 0.05%, 0.1%, 0.5% or 1% to about 30%, 25%, 20%, 10%, 7%, 5%, 3% of one or more plant extracts by weight of the composition. Suitable plant extracts include extracts from plants (herbs, roots, flowers, fruits, seeds), such as flowers, fruits, vegetables, etc., including yeast fermentation extracts, Padina Pavonica extracts, Thermus thermophilis fermentation extracts, Camelina sativa seed oil, boswellia serrata extracts, olive extracts, Arabidopsis Thaliana extracts, Acacia Dealbata extract, Acer Saccharinum (sugar maple), acidophilus, acorus, aesculus, alcaligenes polysaccharides, agaricus, agave, agrimonia, algae, aloe, citrus, brassica, cinnamon, orange, apple, blueberry, cranberry, peach, pear, lemon, lime, pea, seaweed, caffeine, green tea, chamomile, willow bark, mulberry, poppy, etc. Additional specific examples include, but are not limited to, Glycyrrhiza Glabra, Salix Nigra, Macrocycstis Pyrifera, Pyrus Malus, Saxifraga Sarmentosa, Vitis Vinifera, Morus Nigra, Scutellaria Baicalensis, Anthemis Nobilis, Salvia Sclarea, Rosmarinus Officianalis, Citrus Medica Limonum, Ginkgo Biloba, Panax Ginseng, Siegesbeckia Orientalis, Fructus Mume, Ascophyllum Nodosum, Bifidosaccharomyces Ferment Solution, Glycine Soja Extract, Beta Vulgaris, HaberleaRhodopensis, Polygonum Cuspidatum, Citrus Aurantium Dulcis, Grape, Selaginella Tamariscina, Humulus Lupulus, Citrus Reticulata Peel, Punica Granatum, Asparagopsis, Curcuma Longa, Menyanthes Trifoliata, Helianthus Annuus, Hordeum Vulgare, Cucumber Sativus, Evernia Prunastri, Evernia Furfuracea, Laminaria Angustata, Laminaria Cloustoni, Laminaria Digitata, Laminaria Hyperborea, Laminaria Japonica, Laminaria Longissima), Laminaria Ochotensis, Laminaria Ochroleuca, Laminaria Saccharina, and mixtures thereof. Other suitable active ingredients are listed in the functional category of "Biological Products" in the International Cosmetic Ingredient Dictionary and Handbook, 13th Edition, 2010, of the Personal Care Products Association of the United States.

[0349] Any other suitable optional components may also be included in the personal care compositions of the present disclosure, such as those commonly used for a given product type. The International Cosmetic Ingredient Dictionary and Handbook of the Personal Care Products Council of the United States, 13th edition, describes various non-limiting functional materials that can be added to the compositions herein. Examples of these functional categories include, but are not limited to, abrasives, absorbents, fragrances, anti-acne agents, anti-caking agents, defoamers, antimicrobial agents (e.g., iodopropyl butyl carbamate), antifungal agents, antioxidants, adhesives, buffers, fillers, chelating agents, colorants, cosmetic astringents, cosmetic biocides, denaturants, pharmaceutical astringents, external analgesics, film formers, sunscreens, pH regulators, plant derivatives, plant extracts, plant tissue extracts, plant seed extracts, vegetable oils, botanicals, plant extracts, preservatives, propellants, reducing agents, sebum control agents, sequestrants, skin bleaching agents, skin conditioning agents (e.g., moisturizers and occlusive agents) and skin protectants. Other suitable optional personal care ingredients include the materials listed in US Patent Application No. 2010 / 0112100, paragraphs 513-839.

[0350] Methods for treating sensitive skin

[0351] Another aspect of the present disclosure relates to a method for reducing or slowing at least one sign of aging in a subject with sensitive skin, the method comprising applying to the subject a personal care composition described herein. In some embodiments, the application of the personal care composition results in reduced wrinkles or delayed onset of wrinkles.

[0352] Another aspect of the present disclosure relates to a method for treating sensitive skin of a subject, the method comprising applying to the subject a personal care composition described herein. In some embodiments, the sensitive skin exhibits at least one unpleasant sensation prior to the treatment, the at least one unpleasant sensation selected from the group consisting of stinging, warmth, burning, itching, tightness, and erythema.

[0353] In some embodiments, the personal care composition includes niacinamide, Edelweiss (alpine edelweiss) extract, Oryza sativa (rice) sake lees concentrate, panthenol, and soy-derived glycopeptide.

[0354] In some embodiments, the subject includes a human. In some embodiments, the subject has been exposed to pollution. In some embodiments, the subject has been exposed to air pollution. In some embodiments, the subject has been exposed to air pollution with an air quality index (AQI) higher than 100. In some embodiments, the subject is exposed to air pollution with an air quality index (AQI) higher than 150. In some embodiments, the subject is exposed to air pollution with an air quality index (AQI) higher than 200. In some embodiments, the subject is exposed to air pollution with an air quality index (AQI) higher than 250. In some embodiments, the subject is exposed to air pollution with an air quality index (AQI) higher than 300.

[0355] In some embodiments, the personal care composition comprises: (a) 0.1 wt %-10 wt % (e.g., 0.1 wt %, 0.2 wt %, 0.3 wt %, 0.4 wt %, 0.5 wt %, 0.6 wt %, 0.7 wt %, 0.8 wt %, 0.9 wt %, 1 wt %, 1.1 wt %, 1.2 wt %, 1.3 wt %, 1.4 wt %, 1.5 wt %, 1.6 wt %, 1.7 wt %, 1.8 wt %, 1.9 wt %, 2 wt %, 2.1 wt %, 2.2 wt %, 2.3 wt %, 2.4 wt %, 2.5 wt %, 2.6 wt %, 2.7 wt %, 2.8 wt %, 2.9 wt %, 3.1 wt %, 3.2 wt %, 3.3 wt %, 3.4 wt %, 3.5 wt %, 3.6 wt %, 3.7 wt %, 3.8 wt %, 3.9 wt %, 3.1 ... .2 wt%, 3.3 wt%, 3.4 wt%, 3.5 wt%, 3.6 wt%, 3.7 wt%, 3.8 wt%, 3.9 wt%, 4 wt%, 4.1 wt%, 4.2 wt%, 4.3 wt%, 4.4 wt%, 4.5 wt%, 4.6 wt%, 4.7 wt%, 4.8 wt%, 4.9 wt%, 5 wt%, 5.1 wt%, 5.2 wt%, 5.3 wt%, 5.4 wt%, 5.5 wt%, 5.6 wt%, 5.7 wt%, 5.8 wt%, 5.9 wt%, 6 wt%, 6.1 wt%, 6.2 wt%, 6.3 wt%, 6.4 wt%, 6.5 wt%, 6.6 wt%, 6.7 wt%, 6.8 wt%. %, 6.9 wt%, 7 wt%, 7.1 wt%, 7.2 wt%, 7.3 wt%, 7.4 wt%, 7.5 wt%, 7.6 wt%, 7.7 wt%, 7.8 wt%, 7.9 wt%, 8 wt%, 8.1 wt%, 8.2 wt%, 8.3 wt%, 8.4 wt%, 8.5 wt%, 8.6 wt%, 8.7 wt%, 8.8 wt%, 8.9 wt%, 9 wt%, 9.1 wt%, 9.2 wt%, 9.3 wt%, 9.4 wt%, 9.5 wt%, 9.6 wt%, 9.7 wt%, 9.8 wt%, 9.9 wt%, 10 wt%) of niacinamide, (b) 0.0001 wt% to 10 wt% (e.g., 0.0 0.01 wt%, 0.002 wt%, 0.005 wt%, 0.008 wt%, 0.01 wt%, 0.02 wt%, 0.03 wt%, 0.04 wt%, 0.05 wt%, 0.06 wt%, 0.07 wt%, 0.08 wt%, 0.09 wt%, 0.1 wt%, 0.2 wt%, 0.3 wt%, 0.4 wt%, 0.5 wt%, 0.6 wt%, 0.7 wt%, 0.8 wt%, 0.9 wt%, 1 wt%, 1.1 wt%, 1.2 wt%, 1.3 wt%, 1.4 wt%, 1.5 wt%, 1.6 wt%, 1.7 wt%, 1.8 wt%, 1.9 wt%, 2 wt%, 2.1 wt%, 2.2 wt%, 2.3 wt%, 2.4 wt%, 2.5 wt%, 2.6 wt%, 2.7 wt%, 2.8 wt%, 2.9 wt%, 3 wt%, 3.1 wt%, 3.2 wt%, 3.3 wt%, 3.4 wt%, 3.5 wt%, 3.6 wt%, 3.7 wt%, 3.8 wt%, 3.9 wt%, 4 wt%, 4.1 wt%, 4.2 wt%, 4.3 wt%, 4.4 wt%, 4.5 wt%, 4.6 wt%, 4.7 wt%, 4.8 wt%, 4.9 wt%, 5 wt%, 5.1 wt%, 5.2 wt%, 5.3 wt%, 5.4 wt%, 5.5 wt%, 5.6 wt%, 5.7 wt%, 5.8 wt% %, 5.9 wt%, 6 wt%, 6.1 wt%, 6.2 wt%, 6.3 wt%, 6.4 wt%, 6.5 wt%, 6.6 wt%, 6.7 wt%, 6.8 wt%, 6.9 wt%, 7 wt%, 7.1 wt%, 7.2 wt%, 7.3 wt%, 7.4 wt%, 7.5 wt%, 7.6 wt%, 7.7 wt%, 7.8 wt%, 7.9 wt%, 8 wt%, 8.1 wt%, 8.2 wt%, 8.3 wt%, 8.4 wt%, 8.5 wt%, 8.6 wt%, 8.7 wt%, 8.8 wt%, 8.9 wt%, 9 wt%, 9.1 wt%, 9.2 wt%, 9.3 wt%, 9.4 wt%, 9.5 wt%. %, 9.6 wt%, 9.7 wt%, 9.8 wt%, 9.9 wt%, 10 wt%) Edelweiss (alpine edelweiss) extract, (c) 0.001 wt%-10 wt% (e.g., 0.001 wt%, 0.002 wt%, 0.003 wt%, 0.004 wt%, 0.005 wt%, 0.006 wt%, 0.007 wt%, 0.008 wt%, 0.009 wt%, 0.1 wt%, 0.2 wt%, 0.3 wt%, 0.4 wt%, 0.5 wt%, 0.6 wt%, 0.7 wt%, 0.8 wt%, 0.9 wt%, 1 wt%, 1.1 wt%, 1.2 wt%, 1.3 wt%, 1.4 wt%, 1.5 wt%, 1.6 wt%, 1.7 wt%, 1.8 wt%, 1.9 wt%, 2.1 wt%, 2.2 wt%, 2.3 wt%, 2.4 wt%, 2.5 wt%, 2.6 wt%, 2.7 wt%, 2.8 wt%, 2.9 wt%, 3. 5wt%, 1.6wt%, 1.7wt%, 1.8wt%, 1.9wt%, 2wt%, 2.1wt%, 2.2wt%, 2.3wt%, 2.4wt%, 2.5wt%, 2.6wt%, 2.7wt%, 2.8wt%, 2.9wt%, 3wt%, 3.1wt%, 3.2wt%, 3.3wt%, 3.4wt%, 3.5wt%, 3.6wt%, 3.7wt%, 3.8wt%, 3.9wt%, 4wt%, 4.1wt%, 4.2wt%, 4.3wt%, 4.4wt%, 4.5wt%, 4.6wt%, 4.7wt%, 4.8wt%, 4.9wt%, 5wt%, 5.1wt%, 5.%, 5.2 wt%, 5.3 wt%, 5.4 wt%, 5.5 wt%, 5.6 wt%, 5.7 wt%, 5.8 wt%, 5.9 wt%, 6 wt%, 6.1 wt%, 6.2 wt%, 6.3 wt%, 6.4 wt%, 6.5 wt%, 6.6 wt%, 6.7 wt%, 6.8 wt%, 6.9 wt%, 7 wt%, 7.1 wt%, 7.2 wt%, 7.3 wt%, 7.4 wt%, 7.5 wt%, 7.6 wt%, 7.7 wt%, 7.8 wt%, 7.9 wt%, 8 wt%, 8.1 wt%, 8.2 wt%, 8.3 wt%, 8.4 wt%, 8.5 wt%, 8.6 wt%, 8.7 wt%, 8.8 wt% %, 8.9% by weight, 9% by weight, 9.1% by weight, 9.2% by weight, 9.3% by weight, 9.4% by weight, 9.5% by weight, 9.6% by weight, 9.7% by weight, 9.8% by weight, 9.9% by weight, 10% by weight) of rice (paddy rice) sake lees concentrate, (d) 0.1% by weight to 10% by weight (for example, 0.1% by weight, 0.2% by weight, 0.3% by weight, 0.4% by weight, 0.5% by weight, 0.6% by weight, 0.7% by weight, 0.8% by weight, 0.9% by weight, 1% by weight, 1.1% by weight, 1.2% by weight, 1.3% by weight, 1.4% by weight, 1.5% by weight, 1.6% by weight, 1.7% by weight, 1.8% by weight, 1.9% by weight, 2% by weight %, 2.1 wt%, 2.2 wt%, 2.3 wt%, 2.4 wt%, 2.5 wt%, 2.6 wt%, 2.7 wt%, 2.8 wt%, 2.9 wt%, 3 wt%, 3.1 wt%, 3.2 wt%, 3.3 wt%, 3.4 wt%, 3.5 wt%, 3.6 wt%, 3.7 wt%, 3.8 wt%, 3.9 wt%, 4 wt%, 4.1 wt%, 4.2 wt%, 4.3 wt%, 4.4 wt%, 4.5 wt%, 4.6 wt%, 4.7 wt%, 4.8 wt%, 4.9 wt%, 5 wt%, 5.1 wt%, 5.2 wt%, 5.3 wt%, 5.4 wt%, 5.5 wt%, 5.6 wt%, 5.7 %, 5.8 wt%, 5.9 wt%, 6 wt%, 6.1 wt%, 6.2 wt%, 6.3 wt%, 6.4 wt%, 6.5 wt%, 6.6 wt%, 6.7 wt%, 6.8 wt%, 6.9 wt%, 7 wt%, 7.1 wt%, 7.2 wt%, 7.3 wt%, 7.4 wt%, 7.5 wt%, 7.6 wt%, 7.7 wt%, 7.8 wt%, 7.9 wt%, 8 wt%, 8.1 wt%, 8.2 wt%, 8.3 wt%, 8.4 wt%, 8.5 wt%, 8.6 wt%, 8.7 wt%, 8.8 wt%, 8.9 wt%, 9 wt%, 9.1 wt%, 9.2 wt%, 9.3 wt%, 9.4 wt %, 9.5 wt %, 9.6 wt %, 9.7 wt %, 9.8 wt %, 9.9 wt %, 10 wt % of panthenol, and (e) 0.001 wt % to 5 wt % (e.g., 0.001 wt %, 0.002 wt %, 0.003 wt %, 0.004 wt %, 0.005 wt %, 0.006 wt %, 0.007 wt %, 0.008 wt %) of panthenol; %, 0.009 wt%, 0.01 wt%, 0.02 wt%, 0.03 wt%, 0.04 wt%, 0.05 wt%, 0.06 wt%, 0.07 wt%, 0.08 wt%, 0.09 wt%, 0.1 wt%, 0.2 wt%, 0.3 wt%, 0.4 wt%, 0.5 wt%, 0.6 wt%, 0.7 wt%, 0.8 wt%, 0.9 wt% %, 1 wt %, 1.1 wt %, 1.2 wt %, 1.3 wt %, 1.4 wt %, 1.5 wt %, 1.6 wt %, 1.7 wt %, 1.8 wt %, 1.9 wt %, 2 wt %, 2.1 wt %, 2.2 wt %, 2.3 wt %, 2.4 wt %, 2.5 wt %, 2.6 wt %, 2.7 wt %, 2.8 wt %, 2.9 wt %, 3 wt %, 3.1 wt%, 3.2 wt%, 3.3 wt%, 3.4 wt%, 3.5 wt%, 3.6 wt%, 3.7 wt%, 3.8 wt%, 3.9 wt%, 4 wt%, 4.1 wt%, 4.2 wt%, 4.3 wt%, 4.4 wt%, 4.5 wt%, 4.6 wt%, 4.7 wt%, 4.8 wt%, 4.9 wt%, 5 wt%) of soybean-derived glycopeptide.

[0356] In some embodiments, the personal care composition comprises: (a) 0.1 wt%-4 wt% (e.g., 0.1 wt%, 0.2 wt%, 0.3 wt%, 0.4 wt%, 0.5 wt%, 0.6 wt%, 0.7 wt%, 0.8 wt%, 0.9 wt%, 1 wt%, 1.1 wt%, 1.2 wt%, 1.3 wt%, 1.4 wt%, 1.5 wt%, 1.6 wt%, 1.7 wt%, 1.8 wt%, 1.9 wt%, 2 wt%, 2.1 wt%, 2.2 wt%, 2.3 wt%, 2.4 wt%, 2.5 wt%, 2.6 wt%, 2.7 wt%, 2.8 wt%, 2.9 wt%, 3 wt%, 3.1 wt%, 3.2 wt%, 3.3 wt%, 3.4 wt% %, 0.2 wt%, 0.3 wt%, 0.4 wt%, 0.5 wt%, 0.6 wt%, 0.7 wt%, 0.8 wt%, 0.9 wt%, 0.1 wt%, 0.2 wt%, 0.3 wt%, 0.4 wt%, 0.5 wt%, 0.6 wt%, 0.7 wt%, 0.8 wt%, 0.9 wt%, 0.10 wt%, 0.11 wt%, 0.12 wt%, 0.13 wt%, 0.14 wt%, 0.15 wt%, 0.16 wt%, 0.17 wt%, 0.18 wt%, 0.19 wt%, 0.20 wt%, 0.21 wt%, 0.22 wt%, 0.23 wt%, 0.24 wt%, 0.25 wt%, 0.26 wt%, 0.27 wt%, 0.28 wt%, 0.29 wt%, 0.30 wt%, 0.31 wt%, 0.32 wt%, 0.33 wt%, 0.34 wt%, 0.35 wt%, 0.36 wt%, 0.37 wt%, 0.38 wt%, 0.39 wt%, 0.40 wt% .9 wt %, 1 wt %, 1.1 wt %, 1.2 wt %, 1.3 wt %, 1.4 wt %, 1.5 wt %, 1.6 wt %, 1.7 wt %, 1.8 wt %, 1.9 wt %, 2 wt %, 2.1 wt %, 2.2 wt %, 2.3 wt %, 2.4 wt %, 2.5 wt %, 2.6 wt %, 2.7 wt %, 2.8 wt %, 2.9 wt %, 3 wt %, 3.1 wt %, 3.2 wt %, 3.3 wt %, 3.4 wt %, 3.5 wt %, 3.6 wt %, 3.7 wt %, 3.8 wt %, 3.9 wt %, 4 wt %) of Edelweiss (alpine edelweiss) extract, (c) 0.001 wt % to 2 wt % (e.g., %, (d) 0.1% to 3% (e.g., 0.001%, 0.002%, 0.003%, 0.004%, 0.005%, 0.006%, 0.007%, 0.008%, 0.009%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%) of rice (paddy rice) sake lees concentrate, (d) 0.1% to 3% (e.g., 0.001%, 0.002%, 0.003%, 0.004%, 0.005%, 0.006%, 0.007%, 0.008%, 0.009%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%) of rice (pasture) sake lees concentrate,1 wt%, 0.2 wt%, 0.3 wt%, 0.4 wt%, 0.5 wt%, 0.6 wt%, 0.7 wt%, 0.8 wt%, 0.9 wt%, 1 wt%, 1.1 wt%, 1.2 wt%, 1.3 wt%, 1.4 wt%, 1.5 wt%, 1.6 wt%, 1.7 wt%, 1.8 wt%, 1.9 wt%, 2 wt%, 2.1 wt%, 2.2 wt%, 2.3 wt%, 2.4 wt%, 2 .5 wt%, 2.6 wt%, 2.7 wt%, 2.8 wt%, 2.9 wt%, 3 wt%) of panthenol, and (e) 0.002 wt%-4 wt% (e.g., 0.002 wt%, 0.003 wt%, 0.004 wt%, 0.005 wt%, 0.006 wt%, 0.007 wt%, 0.008 wt%, 0.009 wt%, 0.01 wt%, 0.02 wt%, 0.03 wt%, 0. 0.4 wt%, 0.05 wt%, 0.06 wt%, 0.07 wt%, 0.08 wt%, 0.09 wt%, 0.1 wt%, 0.2 wt%, 0.3 wt%, 0.4 wt%, 0.5 wt%, 0.6 wt%, 0.7 wt%, 0.8 wt%, 0.9 wt%, 1 wt%, 1.1 wt%, 1.2 wt%, 1.3 wt%, 1.4 wt%, 1.5 wt%, 1.6 wt%, 1.7 wt%, 1.8 wt%, 1.9 wt%, 2 wt%, 2.1 wt%, 2.2 wt%, 2.3 wt%, 2.4 wt%, 2.5 wt%, 2.6 wt%, 2.7 wt%, 2.8 wt%, 2.9 wt%, 3 wt%, 3.1 wt%, 3.2 wt%, 3.3 wt%, 3.4 wt%, 3.5 wt%, 3.6 wt%, 3.7 wt%, 3.8 wt%, 3.9 wt%, 4 wt%) of soybean-derived glycopeptide. .

[0357] In some embodiments, the personal care composition comprises: (a) 0.1 wt %-10 wt % (e.g., 0.1 wt %, 0.2 wt %, 0.3 wt %, 0.4 wt %, 0.5 wt %, 0.6 wt %, 0.7 wt %, 0.8 wt %, 0.9 wt %, 1 wt %, 1.1 wt %, 1.2 wt %, 1.3 wt %, 1.4 wt %, 1.5 wt %, 1.6 wt %, 1.7 wt %, 1.8 wt %, 1.9 wt %, 2 wt %, 2.1 wt %, 2.2 wt %, 2.3 wt %, 2.4 wt %, 2.5 wt %, 2.6 wt %, 2.7 wt %, 2.8 wt %, 2.9 wt %, 3.1 wt %, 3.2 wt %, 3.3 wt %, 3.4 wt %, 3.5 wt %, 3.6 wt %, 3.7 wt %, 3.8 wt %, 3.9 wt %, 3.1 ... .2 wt%, 3.3 wt%, 3.4 wt%, 3.5 wt%, 3.6 wt%, 3.7 wt%, 3.8 wt%, 3.9 wt%, 4 wt%, 4.1 wt%, 4.2 wt%, 4.3 wt%, 4.4 wt%, 4.5 wt%, 4.6 wt%, 4.7 wt%, 4.8 wt%, 4.9 wt%, 5 wt%, 5.1 wt%, 5.2 wt%, 5.3 wt%, 5.4 wt%, 5.5 wt%, 5.6 wt%, 5.7 wt%, 5.8 wt%, 5.9 wt%, 6 wt%, 6.1 wt%, 6.2 wt%, 6.3 wt%, 6.4 wt%, 6.5 wt%, 6.6 wt%, 6.7 wt%, 6.8 wt%. %, 6.9 wt%, 7 wt%, 7.1 wt%, 7.2 wt%, 7.3 wt%, 7.4 wt%, 7.5 wt%, 7.6 wt%, 7.7 wt%, 7.8 wt%, 7.9 wt%, 8 wt%, 8.1 wt%, 8.2 wt%, 8.3 wt%, 8.4 wt%, 8.5 wt%, 8.6 wt%, 8.7 wt%, 8.8 wt%, 8.9 wt%, 9 wt%, 9.1 wt%, 9.2 wt%, 9.3 wt%, 9.4 wt%, 9.5 wt%, 9.6 wt%, 9.7 wt%, 9.8 wt%, 9.9 wt%, 10 wt%) of niacinamide, (b) 0.0001 wt% to 10 wt% (e.g., 0.0 0.01 wt%, 0.002 wt%, 0.005 wt%, 0.008 wt%, 0.01 wt%, 0.02 wt%, 0.03 wt%, 0.04 wt%, 0.05 wt%, 0.06 wt%, 0.07 wt%, 0.08 wt%, 0.09 wt%, 0.1 wt%, 0.2 wt%, 0.3 wt%, 0.4 wt%, 0.5 wt%, 0.6 wt%, 0.7 wt%, 0.8 wt%, 0.9 wt%, 1 wt%, 1.1 wt%, 1.2 wt%, 1.3 wt%, 1.4 wt%, 1.5 wt%, 1.6 wt%, 1.7 wt%, 1.8 wt%, 1.9 wt%, 2 wt%, 2.1 wt%, 2.2 wt%, 2.3 wt%, 2.4 wt%, 2.5 wt%, 2.6 wt%, 2.7 wt%, 2.8 wt%, 2.9 wt%, 3 wt%, 3.1 wt%, 3.2 wt%, 3.3 wt%, 3.4 wt%, 3.5 wt%, 3.6 wt%, 3.7 wt%, 3.8 wt%, 3.9 wt%, 4 wt%, 4.1 wt%, 4.2 wt%, 4.3 wt%, 4.4 wt%, 4.5 wt%, 4.6 wt%, 4.7 wt%, 4.8 wt%, 4.9 wt%, 5 wt%, 5.1 wt%, 5.2 wt%, 5.3 wt%, 5.4 wt%, 5.5 wt%, 5.6 wt%, 5.7 wt%, 5.8 wt% %, 5.9 wt%, 6 wt%, 6.1 wt%, 6.2 wt%, 6.3 wt%, 6.4 wt%, 6.5 wt%, 6.6 wt%, 6.7 wt%, 6.8 wt%, 6.9 wt%, 7 wt%, 7.1 wt%, 7.2 wt%, 7.3 wt%, 7.4 wt%, 7.5 wt%, 7.6 wt%, 7.7 wt%, 7.8 wt%, 7.9 wt%, 8 wt%, 8.1 wt%, 8.2 wt%, 8.3 wt%, 8.4 wt%, 8.5 wt%, 8.6 wt%, 8.7 wt%, 8.8 wt%, 8.9 wt%, 9 wt%, 9.1 wt%, 9.2 wt%, 9.3 wt%, 9.4 wt%, 9.5 wt%. %, 9.6 wt%, 9.7 wt%, 9.8 wt%, 9.9 wt%, 10 wt%) Edelweiss (alpine edelweiss) extract, (c) 0.001 wt%-10 wt% (e.g., 0.001 wt%, 0.002 wt%, 0.003 wt%, 0.004 wt%, 0.005 wt%, 0.006 wt%, 0.007 wt%, 0.008 wt%, 0.009 wt%, 0.1 wt%, 0.2 wt%, 0.3 wt%, 0.4 wt%, 0.5 wt%, 0.6 wt%, 0.7 wt%, 0.8 wt%, 0.9 wt%, 1 wt%, 1.1 wt%, 1.2 wt%, 1.3 wt%, 1.4 wt%, 1.5 wt%, 1.6 wt%, 1.7 wt%, 1.8 wt%, 1.9 wt%, 2.1 wt%, 2.2 wt%, 2.3 wt%, 2.4 wt%, 2.5 wt%, 2.6 wt%, 2.7 wt%, 2.8 wt%, 2.9 wt%, 3. 5wt%, 1.6wt%, 1.7wt%, 1.8wt%, 1.9wt%, 2wt%, 2.1wt%, 2.2wt%, 2.3wt%, 2.4wt%, 2.5wt%, 2.6wt%, 2.7wt%, 2.8wt%, 2.9wt%, 3wt%, 3.1wt%, 3.2wt%, 3.3wt%, 3.4wt%, 3.5wt%, 3.6wt%, 3.7wt%, 3.8wt%, 3.9wt%, 4wt%, 4.1wt%, 4.2wt%, 4.3wt%, 4.4wt%, 4.5wt%, 4.6wt%, 4.7wt%, 4.8wt%, 4.9wt%, 5wt%, 5.1wt%, 5.2 wt%, 5.3 wt%, 5.4 wt%, 5.5 wt%, 5.6 wt%, 5.7 wt%, 5.8 wt%, 5.9 wt%, 6 wt%, 6.1 wt%, 6.2 wt%, 6.3 wt%, 6.4 wt%, 6.5 wt%, 6.6 wt%, 6.7 wt%, 6.8 wt%, 6.9 wt%, 7 wt%, 7.1 wt%, 7.2 wt%, 7.3 wt%, 7.4 wt%, 7.5 wt%, 7.6 wt%, 7.7 wt%, 7.8 wt%, 7.9 wt%, 8 wt%, 8.1 wt%, 8.2 wt%, 8.3 wt%, 8.4 wt%, 8.5 wt%, 8.6 wt%, 8.7 wt%, 8.8 wt% %, 8.9 wt%, 9 wt%, 9.1 wt%, 9.2 wt%, 9.3 wt%, 9.4 wt%, 9.5 wt%, 9.6 wt%, 9.7 wt%, 9.8 wt%, 9.9 wt%, 10 wt%) of rice (pasteurized water) sake grain concentrate, and (d) 0.1 wt%-10 wt% (e.g., 0.1 wt%, 0.2 wt%, 0.3 wt%, 0.4 wt%, 0.5 wt%, 0.6 wt%, 0.7 wt%, 0.8 wt%, 0.9 wt%, 1 wt%, 1.1 wt%, 1.2 wt%, 1.3 wt%, 1.4 wt%, 1.5 wt%, 1.6 wt%, 1.7 wt%, 1.8 wt%, 1.9 wt%, 2 wt% %, 2.1 wt%, 2.2 wt%, 2.3 wt%, 2.4 wt%, 2.5 wt%, 2.6 wt%, 2.7 wt%, 2.8 wt%, 2.9 wt%, 3 wt%, 3.1 wt%, 3.2 wt%, 3.3 wt%, 3.4 wt%, 3.5 wt%, 3.6 wt%, 3.7 wt%, 3.8 wt%, 3.9 wt%, 4 wt%, 4.1 wt%, 4.2 wt%, 4.3 wt%, 4.4 wt%, 4.5 wt%, 4.6 wt%, 4.7 wt%, 4.8 wt%, 4.9 wt%, 5 wt%, 5.1 wt%, 5.2 wt%, 5.3 wt%, 5.4 wt%, 5.5 wt%, 5.6 wt%, 5. 7 wt%, 5.8 wt%, 5.9 wt%, 6 wt%, 6.1 wt%, 6.2 wt%, 6.3 wt%, 6.4 wt%, 6.5 wt%, 6.6 wt%, 6.7 wt%, 6.8 wt%, 6.9 wt%, 7 wt%, 7.1 wt%, 7.2 wt%, 7.3 wt%, 7.4 wt%, 7.5 wt%, 7.6 wt%, 7.7 wt%, 7.8 wt%, 7.9 wt%, 8 wt%, 8.1 wt%, 8.2 wt%, 8.3 wt%, 8.4 wt%, 8.5 wt%, 8.6 wt%, 8.7 wt%, 8.8 wt%, 8.9 wt%, 9 wt%, 9.1 wt%, 9.2 wt%, 9.3 wt%, 9.4 wt%, 9.5 wt%, 9.6 wt%, 9.7 wt%, 9.8 wt%, 9.9 wt%, 10 wt%) of panthenol.

[0358] In some embodiments, "niacinamide" comprises the formula:

[0359] Derivatives thereof; and salts of any of the foregoing.

[0360] In some embodiments, the personal care composition includes 0.1 wt%-2 wt% (e.g., 0.1 wt%, 0.2 wt%, 0.3 wt%, 0.4 wt%, 0.5 wt%, 0.6 wt%, 0.7 wt%, 0.8 wt%, 0.9 wt%, 1 wt%, 1.1 wt%, 1.2 wt%, 1.3 wt%, 1.4 wt%, 1.5 wt%, 1.6 wt%, 1.7 wt%, 1.8 wt%, 1.9 wt%, 2 wt%) of niacinamide. In some embodiments, the personal care composition includes 0.5 wt%-1.5 wt% (e.g., 0.5 wt%, 0.6 wt%, 0.7 wt%, 0.8 wt%, 0.9 wt%, 1 wt%, 1.1 wt%, 1.2 wt%, 1.3 wt%, 1.4 wt%, 1.5 wt%) of niacinamide.

[0361] In some embodiments, the extract of Edelweiss (alpine edelweiss) comprises chlorogenic acid, chlorogenic acid derivatives, luteolin-7-O-glucoside, luteolin-4'-O-glucoside, apigenin-7-O-glucoside, luteolin and edelweiss acid as bioactive agents. In some embodiments, the extract of Edelweiss (alpine edelweiss) comprises Edelweiss extract.

[0362] In some embodiments, the personal care composition includes 0.1%-2% by weight (e.g., 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%) of Edelweiss (alpine edelweiss). In some embodiments, the personal care composition includes 0.5%-1.5% by weight (e.g., 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%) of Edelweiss (alpine edelweiss).

[0363] In some embodiments, the rice (rice) distiller's grains concentrate includes amino acids, oleic acid, linolenic acid, phytic acid, palmitic acid and vitamin B derivatives as bioactive agents. In some embodiments, the pH of the rice (rice) distiller's grains concentrate is between 4.0 and 7.0. In some embodiments, the specific gravity (d20 / 20) of the rice (rice) distiller's grains concentrate is between 0.99 and 1.05.

[0364] In some embodiments, the personal care composition includes 0.1 wt%-2 wt% (e.g., 0.1 wt%, 0.2 wt%, 0.3 wt%, 0.4 wt%, 0.5 wt%, 0.6 wt%, 0.7 wt%, 0.8 wt%, 0.9 wt%, 1 wt%, 1.1 wt%, 1.2 wt%, 1.3 wt%, 1.4 wt%, 1.5 wt%, 1.6 wt%, 1.7 wt%, 1.8 wt%, 1.9 wt%, 2 wt%) of rice (rice) wine dregs concentrate. In some embodiments, the personal care composition includes 0.5 wt%-1.5 wt% (e.g., 0.5 wt%, 0.6 wt%, 0.7 wt%, 0.8 wt%, 0.9 wt%, 1 wt%, 1.1 wt%, 1.2 wt%, 1.3 wt%, 1.4 wt%, 1.5 wt%) of rice (rice) wine dregs concentrate.

[0365] In some embodiments, "panthenol" comprises the formula:

[0366] Derivatives thereof; and salts of any of the foregoing.

[0367] In some embodiments, the personal care composition includes 0.1% to 2% (e.g., 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%) of panthenol. In some embodiments, the personal care composition includes 0.5% to 1.5% (e.g., 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%) of panthenol.

[0368] In some embodiments, the soy-derived glycopeptide is a glycopeptide derived from highly purified soy fiber. In some embodiments, the soy-derived glycopeptide can be blended with a stabilizer and a preservative. Exemplary soy-derived glycopeptides are sold.

[0369] In some embodiments, the personal care composition does not include any retinoid or retinoid derivative.

[0370] In some embodiments, the personal care composition further comprises at least one of: water, an anti-dehydrating agent, a photoprotective filter, an antioxidant, a preservative, a gelling agent, a solvent, a pH balancing agent, and a surfactant.

[0371] In some embodiments, the anti-dehydration agent includes at least one of xylitol glucoside, anhydroxylitol, and xylitol.

[0372] In some embodiments, the photoprotective filter comprises at least one of zinc oxide, titanium dioxide, and iron oxide.

[0373] In some embodiments, the personal care composition further comprises at least one of hydrolyzed hyaluronic acid, glycerin, sodium hydroxide, phenoxyethanol, xanthan gum, sodium polyacryloyldimethyl taurate, undecane, tridecane, tocopherol, dimethicone, titanium dioxide, tin oxide, and calcium aluminum borosilicate.

[0374] In some embodiments, the personal care composition includes at least one of: hydrolyzed hyaluronic acid (0.001 wt%-0.05 wt%), glycerin (0.1 wt%-7 wt%), sodium hydroxide (0.001 wt%-0.1 wt%), phenoxyethanol (0.1 wt%-1 wt%), xanthan gum (0.05 wt%-0.5 wt%), sodium polyacryloyldimethyl taurate (0.1 wt%-1.2 wt%), an emollient composition including undecane, tridecane and tocopherol (0.05 wt%-0.5 wt%), polydimethylsiloxane (0.5 wt%-5 wt%), a pigment composition including titanium dioxide, tin oxide and calcium aluminum borosilicate (0.005 wt%-0.05 wt%).

[0375] In some embodiments, the emollient composition comprises Cetiol Ultimate TM In some embodiments, the pigment composition includes Syncrystal Gold TM .

[0376] In some embodiments, the personal care composition further comprises an exfoliant. In some embodiments, the exfoliant is jojoba beads containing vitamin E.

[0377] In some embodiments, the personal care composition is a cream, lotion, gel, mask, or spray.

[0378] In some embodiments, said sensitive skin exhibits at least one unpleasant sensation prior to said treatment, said at least one unpleasant sensation selected from the group consisting of stinging, warmth, burning, itching, tightness, and erythema.

[0379] In some embodiments, said applying of said personal care composition results in a reduction in wrinkles or a delay in the onset of wrinkles.

[0380] In some embodiments, the application of the personal care composition reduces the signs of aging by at least 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 50%, 60%, 70%, 80%, 90%, 95%, 99% or more compared to the application of the same compounds without niacinamide, Edelweiss (alpine edelweiss) extract, Oryza sativa (rice) sake grain concentrate, panthenol, and soy-derived glycopeptides.

[0381] In some embodiments, the personal care composition is topically applied. In some embodiments, the personal care composition is applied every hour, every 2 hours, every 3 hours, every 6 hours, every 12 hours or every day, every other day or every three days. Preferably, the composition is applied once, twice or three times a day. In some embodiments, the personal care composition is applied for at least 10 days, 11 days, 12 days, 13 days, 14 days, 15 days, 16 days, 17 days, 18 days, 19 days or 20 days before observing signs of aging of sensitive skin (reduction of wrinkles, for example, reduction, increase in the crow's feet area) or reduction of at least one adverse sensation of sensitive skin (for example, stinging, heating, burning, itching, tightness and erythema).

[0382] Having now generally described the disclosure, the disclosure will be more readily understood by reference to the following examples, which are included merely for the purpose of illustrating certain aspects and embodiments of the disclosure and are not intended to limit the disclosure.

[0383] Examples

[0384] Example 1: In vitro and in vivo testing

[0385] The purpose of this study was to evaluate the in vitro and in vivo effects of the personal care compositions described herein. In some experiments, the personal care compositions included niacinamide, Edelweiss (alpine edelweiss) extract, Oryza sativa (rice) sake lees concentrate, and panthenol as active ingredients. The personal care compositions formulated for sensitive skin in healthy aging as described herein were compared with a serum containing retinol. Specifically, the inventors compared the clinical results of procollagen and proelastin expression, inflammatory response, and aging between the personal care compositions described herein and the retinol serum.

[0386] Materials and methods

[0387] In vitro testing was performed on normal human dermal fibroblasts (NHDF) in culture, adding a test composition containing the same key active ingredients as described above but without retinol, and using a retinol serum as a comparison. The expression of collagen, elastin, IL-8 and PGE-2 was measured 48 hours (aging markers) or 72 hours (inflammatory markers) after treatment.

[0388] In vivo testing evaluated the following signs of aging: surface roughness parameters and wrinkles (crow's feet) after twice daily application of Composition 3, Composition 4 or Retinol Serum for 56 days.

[0389] result

[0390] An important sign of healthy skin aging is the presence of procollagen and elastin, both mRNA and protein expression of which are highly induced by the composition comprising the active ingredients, whereas no effect is observed with each active ingredient alone.

[0391] Signs of skin inflammation were observed in the case of the retinol serum, as measured by the induction of the expression of IL-8 (+582% compared to the control group, p<0.001) and PGE-2 (+104%, p<0.01). This negative inflammatory profile was not observed in the case of the instant composition, which reduced the expression of IL-8 (-97%, p<0.05) and PGE2 (-69%, p<0.01), nor in the facial serum, which reduced IL-8 expression (-81%, p<0.05) and reduced PGE2 (not significant).

[0392] The key active ingredients present in the composition of the present invention showed anti-wrinkle properties, such as a significant reduction in parameter Sa by 9.8% (p=0.0014), smooth skin relief of crow's feet (78%, p=0.0761) and a significant reduction in wrinkles by reducing the negative volume by 21.1% (p=0.001) and the positive volume by 27% (p=0.0014).

[0393] in conclusion

[0394] The results showed that the instant personal care composition displayed similar characteristics to retinol, but without the risk of increased skin sensitivity, as anti-inflammatory effects were recorded in both the face and eye serums. Particularly good performance was observed for the eye serum. Overall, the eye serum and face serum developed for healthy aging of sensitive skin can alleviate the signs of aging while avoiding the skin irritation often caused by retinol.

[0395] Example 2: Clinical study - general results

[0396] The safety and efficacy of an embodiment of the personal care composition described herein, comprising niacinamide, Edelweiss (alpine edelweiss) extract, Oryza sativa (rice) sake lees concentrate, panthenol, and highly purified soy-based glycoprotein (Composition A) as active ingredients, were evaluated during the following multicenter clinical study conducted on 2 groups of subjects: 44 Caucasian and 46 Asian women, who applied a cream comprising the composition to the entire face twice a day for 8 and 12 weeks, respectively.

[0397] Table 1: Exemplary compositions used in clinical studies.

[0398]

[0399] Safety was assessed by patch testing, human repetitive injury patch testing (HRIPT), photosensitivity, noncomedogenicity studies, and a 2-month in-use multicenter study. Efficacy was assessed by clinical scoring by expert raters during a 2- or 3-month in-use multicenter study, instrumental analysis (skin relief analysis during in-use studies), hydration and transepidermal water loss (TEWL) measurements, antioxidant effects, and a self-assessment questionnaire.

[0400] result

[0401] Hydration and TEWL analysis showed moisturizing effects, with significant improvement in hydration immediately after application (68% vs. control at 1 hour, p<0.05), maintained until 24 hours (+12%, p<0.05), and a significant reduction in TEWL measurements after 1 hour, showing protection against water loss. Thus, the compositions described herein provide immediate and long-lasting hydration as well as immediate skin barrier protection.

[0402] The application of compositions 1-5 provided significant antioxidant properties (calculated protection index of 36.1%, p<0.05). In fact, the concentration of squalene was statistically significantly higher in the treated and exposed areas compared to the untreated exposed areas (+48%, p<0.05).

[0403] The dermatologist-controlled self-assessment questionnaire showed that compositions 1 to 5 had a good effect on sensitive skin. In both groups, after 4 weeks of using the facial serum, a significant reduction in the overall feeling score was observed (Asian - 83%, Caucasian - 66%, p < 0.05), which helps to reduce skin sensitivity, making it more comfortable, less reactive and healthier looking.

[0404] In use tests, clinical scores showed improvements in skin radiance, radiance, evenness, texture, firmness and elasticity, as well as the appearance of wrinkles and fine lines. Wrinkle imaging and relief analysis showed that after 4 weeks of daily application of the facial serum, total wrinkle surface (-23% relative to baseline, p<0.05), total wrinkle length (-16%, p<0.05) and total depth (-15%, p<0.05) were reduced.

[0405] A self-assessment questionnaire assessing satisfaction with compositions 1-5 showed that for both volunteer sets, volunteers highly appreciated the effects on skin hydration, radiance, fine lines and wrinkles, as well as on skin firmness, suppleness and elasticity, and fatigue.

[0406] in conclusion

[0407] Sensitive skin ages faster than normal skin, so the inventors tested the safe and tolerable personal care composition described herein for healthy sensitive skin aging. The blend of five ingredients present in the personal care composition provides clinical benefits to sensitive skin in terms of long-lasting moisturization, protection of the skin barrier, antioxidant properties, and favorable effects on sensitive skin. Notably, the skin is more radiant and elastic, shows fewer and shorter wrinkles, and has a high aesthetic value.

[0408] Example 3: Clinical Assessment - Details

[0409] The following clinical tests were conducted with the disclosed products including panthenol, edelweiss extract and rice sake lees concentrate as active ingredients: single patch test, HRIPT, phototoxicity, photosensitivity, use test under dermatological and ophthalmological control + efficacy-Asian set, use test under dermatological control + efficacy-Caucasian set, hydration and TEWL (short-term effect), non-comedogenic study, in vivo antioxidant test, deep cleansing / anti-pollution test, makeup removal test (only for cleansing milk) and barrier restoration study. The test products were in the form of cleansing water, night cream, face serum, eye serum and day cream.

[0410] Single patch test 48 hours

[0411] Subject population: Healthy, Number of subjects: 18 [14 females - 4 males], Mean age of subjects: 31 [18-45 years].

[0412] Methods: A single 48-hour topical application was performed under an occlusive patch on the upper back.

[0413] Evaluation criteria: Dermatologists evaluated the average irritation index. MCII = 0.06 - judged as good.

[0414] Results: No irritation was observed under the conditions studied.

[0415] HRIPT (Human Repetitive Injury Patch Test)

[0416] Subject population: Healthy, number of subjects: 97 [79 females-18 males], mean age: 49.2 [19-70 years].

[0417] Methods: Repeated 48-hour topical applications were performed under an occlusive patch on the upper back.

[0418] Evaluation criteria: Dermatologists evaluated the mean irritation index and delayed contact sensitization by visual assessment.

[0419] Results: Under the conditions studied, no primary or cumulative irritation or any sensitization reactions were recorded.

[0420] Phototoxicity and photosensitivity

[0421] Subject population: Healthy, number of subjects: 27 [15 females-12 males], mean age: 44.3 [22-64 years].

[0422] Methods: Single and repeated topical applications under an occlusive patch on the upper back followed by sunlight exposure (UV-B&A and UV-A).

[0423] Evaluation criteria: Dermatologists evaluated the mean irritation index and delayed contact sensitization by visual assessment.

[0424] Results: No phototoxic or photosensitizing reactions were observed under the conditions studied.

[0425] Tested for use under normal dermatological and ophthalmological controls

[0426] Subjects: Subject group: Healthy, all skin types - 2 groups of Asians and Caucasians. Number of subjects: 44 (France), mean age 41,7 (25 to 58 years); 43 (China), mean age 43,8 (26 to 54 years); 100% of subjects had sensitive skin (specific questionnaire included), phototypes: France: I (2%), II (41%), III (57%); China: III (70%), IV (28%), V (2%). Subjects lived in polluted environments or urban landscapes. Subjects had uneven skin tone.

[0427] Mode of application: Under normal conditions of use, on the entire face, twice a day on average, for 4 weeks.

[0428] Evaluate:

[0429] Tolerance: Dermatologist and Ophthalmologist *Evaluation of skin and ocular / periocular acceptability at D0 and D28 ( * Asian group only).

[0430] Efficacy: Clinical evaluation (scoring) was performed by a dermatologist on D0, D0Timm, D14 and D28 for the following criteria: skin gloss, skin uniformity, skin luminosity, skin texture, skin firmness, skin elasticity and skin suppleness. Photos were taken using the Colorface device on D0, D0Timm, D14 and D28. Sensory evaluation (Misery Questionnaire) was performed on D0, D14 and D28. Healthy Aging (HA) Index was calculated on D0 and D28 (overall score: "yes" answers to 10 questions). Subjects filled in a self-assessment questionnaire on D0, D14 and D28 immediately after the first application. A skin sensitivity questionnaire was filled in on D28 in the presence of a dermatologist.

[0431] in conclusion:

[0432] Tolerability: (China, n=42 - France, n=44) After repeated application to the entire face twice daily for 4 consecutive weeks under normal use conditions by 42 healthy Asian subjects, the acceptability of the eye, periocular and skin was generally judged to be good.

[0433] Skin acceptability was judged as good overall after repeated application to the entire face twice daily for 4 consecutive weeks under normal use conditions in 44 healthy female (Caucasian) adult subjects. Participants reported improvements in skin radiance, uniformity / evenness, luminosity, texture, firmness, elasticity, and suppleness. The Sensiscale D28 questionnaire found significant reductions in skin irritation, tightness / tightness, general discomfort, and redness (Caucasian subjects overall, -66%, and Asian subjects, -94%).

[0434] Health Index

[0435] The health index is the sum of ten specific prompts that assess skin condition. For each question, 10 is the best rating ("I totally agree") and 0 is the worst ("I totally disagree"). The ten prompts in the health index are as follows:

[0436] 1. My skin looks healthy.

[0437] 2. I can control my sensitive skin.

[0438] 3. Both my skin aging and skin sensitivity are under control.

[0439] 4. I look natural.

[0440] 5. I look relaxed in my skin.

[0441] 6. My skin makes me look radiant.

[0442] 7. My skin makes me look healthy.

[0443] 8. I feel more confident in my skin.

[0444] 9. I feel like I can age gracefully.

[0445] 10. Despite the harsh conditions (sun, cold, stress, pollution), I remain confident with my sensitive skin.

[0446] The subjects were administered a health index questionnaire on clinical testing days 0 and 28. The subjects reported significant improvements in health index on D28 (75% improvement for Caucasian subjects and 69% improvement for Asian subjects compared to D0).

[0447] Skin sensitivity test

[0448] In the skin sensitivity measurement (dermatologist-controlled self-assessment after 28 days of use), subjects reported that the product helped reduce skin sensitivity (95% of the Asian group and 71% of the Caucasian group), and that the skin was more comfortable (100% of the Asian group and 88% of the Caucasian group) and looked healthier (95% of the Asian group and 76% of the Caucasian group) after 28 days of use.

[0449] Non-comedogenic studies

[0450] Subject population: Healthy, acne-prone skin on the face. Subjects had mixed to oily skin on the face, and 25% of the subjects had a history of allergies. Number of subjects: 40 females, mean age: 30.3 [19-40 years].

[0451] Method: Repeat application to the face twice daily under normal use conditions for 4 consecutive weeks.

[0452] Evaluation criteria: Clinical assessment of facial skin acceptability and counts of acneiform lesions by dermatologists.

[0453] Results: Skin acceptability was judged as very good and probably noncomedogenic under the study conditions.

[0454] Hydration - TEWL Study

[0455] Subject population: Healthy, dry skin (AU<50). Number of subjects: 20 females. Mean age: 58 years [30-70].

[0456] Methods: A single standardized application was performed on the forearm, and moisturizing effect and transepidermal water loss (TEWL) were assessed T1H, T4H, T8H, and T24H after application.

[0457] Evaluation criteria: Transepidermal water loss Value and skin hydration Any unit

[0458] Results: Statistically significant effects on the level of moisturization of the upper layers of the epidermis were observed 1 hour (+39% - +65%), 4 hours (+19% - +41%), 8 hours (+16% - +36%) and 24 hours (+6% - +17%) after a single standardized application compared to baseline and untreated areas. The results indicate that the instant personal care composition continues to moisturize the skin up to 24 hours. A statistically significant effect on TEWL was observed 1 hour after application (-14%) compared to baseline and untreated areas. The results indicate that the instant personal care composition protects / respects / maintains the skin barrier.

[0459] In vivo antioxidant studies

[0460] Number of subjects: 10 females, skin phototype II to IV. Mean age: 40 years [24-54].

[0461] Methods: Antioxidant efficacy was assessed by comparing the difference in squalene content between untreated and treated areas after oxidative stress (modeled by exposure to cigarette smoke for 15 minutes). If the composition showed an antioxidant effect, squalene content should be higher in the treated areas.

[0462] Evaluation criteria: Squalene concentration (μg / mg)

[0463] Results: A statistically significant increase in squalene concentration was observed in the treated / exposed groups compared to the untreated / exposed groups. These results indicate the antioxidant effect of the tested products. The protection index was calculated to be between 32.6% and 36.1%.

[0464] Deep Cleansing / Anti-Pollution Research

[0465] Number of subjects: 22 females, skin phototypes I to IV. Mean age: 34 years [18-60].

[0466] Methods: Instant personal care compositions were evaluated for their ability to clean particles used as a model of contamination relative to a control area cleaned with water alone.

[0467] Evaluation criteria: Number of particles removed after cleaning and calculation of cleaning power.

[0468] Results: The areas cleansed with the instant personal care composition removed a statistically significant increase in the number of particles compared to the areas cleansed with water, demonstrating the power of the instant composition against particles used as a pollution model.

[0469] Statistically significant cleaning was observed for the microparticles used as a pollution model. Considering the cleaning power of the instant personal care composition (C% = +44%), it can be considered to have deep cleaning power.

[0470] Makeup removal effect (for cleansing water)

[0471] Number of subjects: 21 females, skin phototype: I to IV. Mean age: 46 years [20-60].

[0472] Methods: The makeup removal effect of cleansing water was evaluated.

[0473] Evaluation criteria: Gray level measured by image analysis using image processing software (eg, Photoshop).

[0474] Results: After applying foundation (t1), data analysis showed a statistically significant decrease in "grey levels" compared to bare skin (t0) (p<0.0001). After cleansing with the instant personal care composition (t2), data analysis showed a statistically significant increase in "grey levels" compared to after applying foundation (t1) (p=<0.0001).

[0475] After a standardized application of foundation, the product achieved an 84% clear skin level.

[0476] Barrier restoration studies (repair effects)

[0477] Number of subjects: 25 healthy women. Mean age: 47.7 years [18-60], phototypes and skin origins as follows: I: 5 (20.00%); II: 10 (40.00%); III: 9 (36.00%); IV: 1 (4.00%); V: 0 (0.00%). Forearm skin type: D0: 40 cm from the body (forearm) by a trained technician. 2 2mg / cm 2 D1 to D14: Home Application - Once daily, subjects applied a thin layer of product to the designated areas.

[0478] Methods: On-site at D0 and then self-applied once daily by the subjects under normal use conditions on a dedicated site located on one forearm. Two areas were designated on each forearm: a control area and a treated area. Tape stripping was used to alter the skin barrier function at D0T0 until the TEWL measurement was greater than 20 g / m2 / h.

[0479] Transepidermal water loss (TEWL) was measured at D0T0 (before peeling) (baseline), D0T0' (immediately after peeling), D3, D7 and D14.

[0480] Evaluation criteria: Transepidermal water loss was measured. At baseline (before tape stripping), there was no statistically significant difference in TEWL values ​​between untreated and treated sites. At baseline (after tape stripping), there was no statistically significant difference in TEWL values ​​between untreated and treated sites.

[0481] Evaluation of treated and untreated sites at all time points after baseline showed statistically significant decreases (improvements) in TEWL values ​​for both treated and untreated sites when compared to baseline measurements after tape stripping, indicating improved skin barrier repair function.

[0482] Comparing the treatment differences between treated and untreated sites, based on the immediate changes after tape stripping, the treated sites had greater improvements in skin barrier function repair (TEWL) values ​​at the immediate (15 minutes) time point.

[0483] Comparing treated and untreated sites, the treated sites showed significantly greater recovery at the immediate (15-minute) time point. By day 3, the treated sites were not significantly different from pre-strip baseline values ​​compared to the untreated sites.

[0484] Under the study conditions, a single treatment with Test Product Composition 5 restored the skin barrier function at the immediate (15 minutes) time point evaluated. Under the study conditions, once-daily treatment with Test Product Composition 5 or Composition 3 showed a skin barrier restoration effect by day 3.

[0485] Example 4: Detailed results of clinical trials

[0486] Composition 1

[0487] The clinical results of Composition 1 are summarized in Table 2.

[0488] Table 2: Clinical results of Composition 1

[0489]

[0490]

[0491] Composition 2

[0492] The skin acceptability of Composition 2 was generally judged as good after repeated application to the entire face once a day under normal use conditions for 4 consecutive weeks by 39 female adult subjects aged 31 to 55 years, with all types of "sensitive" facial skin, phototypes I to IV, and meeting the predefined inclusion criteria.

[0493] Additionally, a single control application of the study product resulted in statistically significant improvements in wrinkle severity (crow's feet area), skin gloss, and skin luminosity immediately following study product application compared to the initial assessment, according to clinical evaluations performed by dermatologist investigators.

[0494] In addition, repeated once-daily applications of the study product to the same subjects over a 4-week period resulted in:

[0495] a. According to clinical evaluations performed by dermatologist researchers, statistically significant improvements were observed in all evaluation criteria (except skin elasticity and skin pliability / mobility) after 2 weeks of use and in all evaluation criteria (except skin pliability / mobility) after 4 weeks of use compared to the initial evaluation;

[0496] b. According to the self-assessment scale filled in by the subjects, the overall score obtained with the Sensiscale questionnaire decreased statistically significantly and favorably after 4 weeks of use compared to the initial assessment, which shows evidence of reduced skin sensitivity; According to the self-assessment scale filled in by the subjects, the global score obtained with the "Healthy Aging Score" questionnaire increased statistically significantly and favorably after 4 weeks of use compared to the initial assessment;

[0497] c. According to the copy analysis (Quantilines TM Software), Rt (maximum amplitude), Rm (maximum roughness), Rz (mean roughness), Rp (smoothness-depth) and surface (percentage of developed surface) parameters were statistically significantly reduced after 2 and 4 weeks of use, in addition, volume (V / mm 2 ) parameter was statistically significantly reduced compared to the initial value, showing evidence of a smoothing effect (effect on fine lines).

[0498] In addition, subjects were very satisfied with the cosmetic quality and efficacy of the product, with 85% and 67% of subjects rating its cosmetic acceptability and efficacy as "good" to "very good", respectively.

[0499] The clinical results of Composition 2 are summarized in Table 3.

[0500] Table 3: Clinical results of Composition 2

[0501]

[0502] Composition 3

[0503] The clinical results of Composition 3 are summarized in Table 4.

[0504] Table 4: Clinical results of Composition 3

[0505]

[0506]

[0507] Composition 4

[0508] The clinical results of Composition 4 are summarized in Table 5.

[0509] Table 5: Composition 4 Clinical Results

[0510]

[0511] Composition 5

[0512] The clinical results of Composition 5 are summarized in Table 6.

[0513] Table 6: Clinical results of Composition 5

[0514]

[0515] Clinical trials have shown that after using the personal care compositions described herein, the following benefits are generally observed:

[0516] Healthy and youthful skin

[0517] ●Skin feels energized, nourished / hydrated, skin appears healthier (↑ radiance, texture, firmness, elasticity, flexibility, wrinkles, fine lines)

[0518] ●Skin looks radiant and bright, shiny / glowing.

[0519] ● Provides a fresh "healthy glow": restores healthy skin.

[0520] ● Makes skin look younger (improves texture, firmness, elasticity, flexibility, wrinkles, fine lines)

[0521] ●Improve uneven skin and dullness. Skin texture looks smoother.

[0522] ●Skin appears firmer, more pliable, feels more elastic, and energized / plumped. Fine lines appear reduced / smoothed

[0523] ● Improves skin quality and appearance over time

[0524] ●Helps reduce visible signs of fatigue (improves texture, firmness, elasticity, flexibility, wrinkles, fine lines)

[0525] ●Skin becomes stronger / more elastic to combat premature aging.

[0526] Skin Barrier:

[0527] Skin appears repaired and protected. More elastic to combat premature aging (100% from questionnaire).

[0528] ●After 10 days of using the product on damaged skin, the protective effect / skin barrier was improved.

[0529] Hydration

[0530] Hydrate the skin immediately and keep it hydrated for 24 hours (see Figure 2 ).

[0531] ●Skin feels completely nourished, hydrated and plump.

[0532] Sensitive skin

[0533] ●Suitable for sensitive skin. Has a soothing effect. Soothes the skin.

[0534] ● Helps reduce skin sensitivity, making the skin more comfortable and less reactive (see Figure 1 ).

[0535] Example 5: Mitochondrial Research

[0536] Environmental insults such as UV light and pollution promote skin aging. The phenotypic manifestations of skin aging include wrinkle formation, dryness, loss of elasticity, flexibility, firmness, radiance, pigmentation and increased skin sensitivity. At the cellular level, mitochondria are believed to be a key factor in aging as cellular bioenergy factories. From a biochemical point of view, it has been observed that mitochondria of aging skin show increased NADPH-oxidase, decreased mitochondrial membrane potential (MMP), unbalanced fusion-fission of fragmented mitochondria and increased mitochondrial associated endoplasmic membrane (MAM). The disclosed personal care compositions were tested for their effects on mitochondrial function and protection as described below.

[0537] Table 7: The following is an exemplary personal care composition (Composition A) for use in a mitochondrial assay.

[0538]

[0539] Composition A was tested in DMSO at dilutions of 1 / 200 (0.5%), 1 / 2,000 (0.05%), and 1 / 20,000 (0.005%) (compared to the concentrations listed above in Table 7). Finally, a dilution of 0.005% was chosen for all mitochondrial experiments as this dilution had the least effect on cell viability.

[0540] Cells used in the study: Fibroblast cultures from a mature donor (54 years old) validated for contamination susceptibility and mitochondrial poisoning.

[0541] Pollutants: Urban standardized particles consisting of micrometer-sized metals, polycyclic aromatic hydrocarbons (PAHs), nitro-PAHs, PCBs, chlorinated pesticides, etc.

[0542] NADPH-oxidase activity, mitochondrial membrane potential (MMP), fusion-fission balance, mitochondrial associated membrane (MAM), and cell viability were measured. The results of these assays are as follows.

[0543] NADPH-oxidase activity

[0544] NADPH oxidase is an enzyme that catalyzes the production of superoxide anions. It is dormant in resting cells and activated upon stress. NADPH oxidase activity generates reactive oxygen species (ROS) that participate in different physiological mechanisms. After pollution, NADPH oxidase is highly stimulated and produces large amounts of ROS. This leads to the production of skin inflammation and in particular the release of the sensitive skin mediator PGE-2. Inactivation of pollutants and / or regulation of NADPH oxidase can protect cells from oxidative damage.

[0545] Method: Cells were incubated with the test element (pollutant or composition A) for 30 minutes. NADPH oxidase activity was immediately determined using chemiluminescence. Conditions: Untreated and not exposed to pollution, untreated and exposed to pollution, and treated with personal care composition and exposed to pollution.

[0546] Results: Pollution-induced NADPH oxidase activity (p = 0.0041) ( Figure 6 , PE-NTC), while composition A significantly (p=0.0053) inhibited the pollution-induced NADPH oxidase activity ( Figure 6 , PE+ treatment). These results show that composition A has antioxidant and antifouling effects.

[0547] Mitochondrial membrane potential

[0548] Mitochondrial membrane potential (MMP) is the main driver of ATP synthesis (cellular fuel). A decrease in MMP (depolarization) can be a sign of mitochondrial damage by oxidative stress and is observed during aging. Pollution-induced depolarization leads to reduced production of ATP (cellular fuel) and ultimately premature aging.

[0549] Method: Pre-incubate cells with probes. Then, incubate cells with test elements (pollutants or active substances) for 4 hours. MMPs are immediately recorded using chemiluminescence. Conditions: Untreated and not exposed to pollution, untreated and exposed to pollution, and treated with composition A and exposed to pollution.

[0550] Results: Pollution induced adverse mitochondrial depolarization (-34%, p=0.0151), and personal care products significantly mitigated the effects of pollution (+20%, p=0.0145) ( Figure 7 ). After treatment with the personal care product, mitochondrial membrane potential returned to a level that was not significantly different from the basal state. Composition A maintains the cellular energy factory in the event of pollution to support the normal function of mitochondria.

[0551] Fission-fusion balance

[0552] The mitochondrial network is a balance between the elongated and fission forms of mitochondria. This balance is dynamic to ensure healthy mitochondrial activity. Stress, like pollution, can damage some mitochondria. It is critical that cells remove damaged mitochondria and generate new ones in a balanced manner. Imbalances in the mitochondrial network increase in different conditions and diseases. A hallmark of aging is a shift toward fragmented mitochondria.

[0553] Method: Cells are pre-incubated with the probe. Then, cells are incubated overnight with the test element (contaminant or active substance). Mitochondrial fusion parameters ( Fig. 8A ) were immediately measured using the Mitosteam technique. Conditions: untreated and unexposed to pollution, untreated and exposed to pollution and treated with composition A and exposed to pollution.

[0554] Results: Pollution inhibited mitochondrial fusion. After pollution exposure, excessive fusion disappeared (p<0.0001)( Figure 8B fusion was reduced by 96% (p<0.0001), and long mitochondria were reduced by 86% (p<0.0001) ( Figure 8B ). After treatment with Composition A, the pollution-induced reduction in mitochondrial length and complexity was alleviated: hyperfusion returned to normal levels. Fusion increased by 2156% (p<0.0001), and long mitochondria increased by 475% (p<0.0001) ( Figure 8B ).

[0555] Pollution induced a shift towards fission in the mitochondrial network: an increase of +17% (p=0.06) in hyperfission, 31% (p<0.0001) in fission, and 20% (p<0.0001) in short mitochondria was observed ( Figure 8C ). After treatment with Composition A, the pollution-induced increase in mitochondrial fission was reversed back to normal. Hyperfission was reduced by 22% (p<0.0001), fission was reduced by 21% (p<0.0001), and short mitochondria increased by 15% (p<0.0001) ( Figure 8C ).

[0556] Mitochondrial network

[0557] Next, Composition A was tested on the cellular mitochondrial network. Pollution caused the mitochondrial network to collapse, while treatment with Composition A preserved the complexity and branching of the mitochondrial network under the challenge of pollution.

[0558] Composition A preserves the complexity and branching of the mitochondrial population and prevents pollution-induced damage to the mitochondrial network and protects the skin from premature aging.

[0559] Mitochondria-associated endoplasmic reticulum membrane (MAM)

[0560] Organelles are in close proximity within cells. MAM is a highly specialized domain between the endoplasmic reticulum (ER) and mitochondria. Urban pollution leads to an increase in MAM through ER stress. MAM is the site of inflammasome formation. In the presence of damaged mitochondria, inflammasome formation increases and leads to aging through the process of "inflammaging".

[0561] Method: Cells were pre-incubated with probes. Cells were then incubated overnight with the test element (contaminant or composition A). The ligation assay measured the distance between GRP75 (mitochondrial membrane) and SERCA2 (endoplasmic reticulum) - a distance <40nm was considered a positive result. Conditions: Untreated and not exposed to contamination, untreated and exposed to contamination, and treated with composition A and exposed to contamination.

[0562] Results: The personal care composition significantly (p<0.0001) reduced the number of MAMs in pollution-damaged cells by 66% ( Fig.10 ).

[0563] Cell viability

[0564] The effect of composition A was tested to assess cell viability.

[0565] Method: Incubate cells with test element (contaminant or active substance) overnight. Determine cell number per microscopic field. Conditions: Untreated and not exposed to contamination, untreated and exposed to contamination and treated with composition A and exposed to contamination.

[0566] Results: Contamination had no effect on cell number (p=0.30). Despite the presence of contamination, Composition A increased cell number by 118% (p<0.0001) ( Fig.11 ).

[0567] In summary, Composition A counteracted multiple signs of pollution-induced mitochondrial defects that are also observed during aging.

[0568] Example 6: Mitochondrial studies of personal care compositions including soy-derived glycopeptides

[0569] From a biochemical perspective, it has been observed that mitochondria of aged skin exhibit increased NADPH-oxidase enzyme activity, decreased mitochondrial membrane potential (MMP), unbalanced fusion-fission of fragmented mitochondria, and increased mitochondrial associated endoplasmic membrane (MAM). The disclosed personal care compositions (see Table 8) were tested for their effects on mitochondrial function and protection as described below.

[0570] Table 8: Exemplary personal care compositions for use in mitochondrial assays (Composition B).

[0571] Element quantity Edelweiss Extract (prepared solution) 3.0％ Hydrolyzed soy flour concentrate (dissolved in water, caprylyl glycol and 1,2-hexanediol) (prepared solution) 2.0％ Niacinamide 1.50％ Provitamin B5 (Panthenol) 2.50％ Rice fermented product (from Japanese sake koji) extract (rice (paddy rice) sake lees concentrate) (prepared solution) 1.00％

[0572] As a comparison to the personal care composition, low ("Niacinamide (Low)") and high ("Niacinamide (High)") concentrations of niacinamide were tested in DMSO. (The high niacinamide concentration is 6.67 times the low niacinamide concentration.) Composition B was diluted to have the same niacinamide concentration as the niacinamide (Low) concentration. The cells used in the study were human primary fibroblasts derived from a 55-year-old healthy female donor. As in Example 5, the pollutants were urban standardized particles consisting of micron-diameter metals, polycyclic aromatic hydrocarbons (PAHs), nitro-PAHs, PCBs, chlorinated pesticides, etc.

[0573] NADPH-oxidase activity and mitochondrial associated membrane (MAM) were experimentally determined and quantified in the same manner as in Example 5. The results of these assays are as follows.

[0574] NADPH-oxidase activity

[0575] result: Fig.12The data presented show a clear antioxidant effect of Nicotinamide (Low), Nicotinamide (High), and Composition B (Diluted), wherein Nicotinamide (Low) restored NADPH activity to a level similar to that observed in NE-NTC. Nicotinamide (High) and Composition B (Diluted) both reduced the level of NADPH oxidase activity to a level below that observed in NE-NTC.

[0576] Mitochondria-associated endoplasmic reticulum membrane (MAM)

[0577] Results: Fig.13 As shown, pollution increased the density of MAMs in exposed cells, which is consistent with increased ER stress and increased storage of intracellular calcium in mitochondria. This effect was reduced to normal levels with composition B (diluted), which is comparable to the levels observed in NE-NTC. The personal care composition (composition B) significantly (p<0.0001) reduced the number of MAMs in pollution-damaged cells by approximately 60%.

[0578] In conclusion, composition B efficiently reduced NADPH-oxidase activity and the occurrence of MAM, which is responsible for the increased mitochondrial calcium influx. Thus, composition B counteracted multiple signs of pollution-induced mitochondrial defects, which are also observed during aging.

Claims

1. A personal care composition, based on the weight of the total composition, comprising: (a) 0.1%-10% niacinamide, (b) 0.0001% to 10% of Leontopodium alpinum extract, (c) 0.001% to 10% of rice (Oryza sativa) sake lees concentrate, (d) 0.1% to 10% panthenol, and (e) 0.001%-5% soybean-derived glycopeptide.

2. The personal care composition of claim 1, wherein the personal care composition comprises, by weight of the total composition: 0.1%-4% niacinamide, 0.001%-4% Edelweiss (alpine edelweiss) extract, 0.001%-2% rice (rice) sake lees concentrate, 0.1%-3% panthenol, and 0.002%-4% soy-derived glycopeptide.

3. The personal care composition according to any one of the preceding claims, wherein the personal care composition does not comprise any retinoid or retinoid derivative.

4. The personal care composition according to any one of the preceding claims, further comprising at least one of the following: water, adenosine, humectants, photoprotective filters, antioxidants, preservatives, gelling agents, solvents, pH balancing agents and surfactants.

5. The personal care composition of claim 4, wherein the humectant comprises at least one of Buddleja davidii extract, Thymus vulgaris extract, caprylyl glycol, glycerin, 1,2-hexanediol, and butylene glycol.

6. The personal care composition according to any one of claims 1 to 5, further comprising, by weight of the total composition: 0.01%-2% adenosine, 0.0001%-3% Buddleja oleifera extract, and 0.0001%-3% thyme extract.

7. The personal care composition of claim 5, wherein the photoprotective filter comprises at least one of zinc oxide, titanium dioxide, and iron oxide.

8. A personal care composition according to any one of the preceding claims, wherein the personal care composition is a cream, a lotion, a gel, a mask, a serum or a spray.

9. A method for treating sensitive skin in a subject, the method comprising applying to the subject a personal care composition comprising: niacinamide, Edelweiss (alpine edelweiss) extract, Oryza sativa (Rice) sake lees concentrate, panthenol, and soy-derived glycopeptide.

10. The method according to claim 9, wherein the sensitive skin exhibits at least one unpleasant sensation prior to the treatment, the at least one unpleasant sensation selected from the group consisting of stinging, warmth, burning, itching, tightness and erythema.

11. The method of claim 10, wherein said applying of said personal care composition results in a reduction in wrinkles or a delay in the onset of wrinkles.

12. The method of any one of claims 9 to 11, wherein the personal care composition does not comprise any retinoid or retinoid derivative.

13. The method of any one of claims 9 to 12, wherein the personal care composition comprises, by weight of the total composition: (a) 0.1%-10% niacinamide, (b) 0.0001% to 10% of Edelweiss (alpine edelweiss) extract, (c) 0.001% to 10% of rice (paddy) sake lees concentrate, (d) 0.1% to 10% panthenol, and (e) 0.001%-5% soybean-derived glycopeptide.

14. The method of any one of claims 9 to 13, wherein the personal care composition comprises, by weight of the total composition: 0.1%-4% niacinamide, 0.001%-4% edelweiss (alpine edelweiss), 0.001%-2% rice (rice) sake lees concentrate, 0.1%-3% panthenol and 0.002%-4% soy-derived glycopeptide.

15. The method according to any one of claims 9 to 14, wherein the personal care composition comprises at least one of the following: water, adenosine, humectants, photoprotective filters, antioxidants, preservatives, gelling agents, solvents, pH balancing agents and surfactants.

16. The method of claim 15, wherein the moisturizer comprises at least one of: Buddleja macrophylla extract, thyme extract, caprylyl glycol, glycerin, 1,2-hexanediol, and butylene glycol.

17. The method of any one of claims 9 to 16, wherein the personal care composition further comprises, by weight of the total composition: 0.01%-2% adenosine, 0.0001%-3% Buddleja oleifera extract, and 0.0001%-3% thyme extract.

18. The method of claim 15, wherein the photoprotective filter comprises at least one of zinc oxide, titanium dioxide, and iron oxide.

19. The method according to any one of claims 9 to 18, wherein the personal care composition is a cream, a lotion, a gel, a mask, a serum or a spray.

20. The method of any one of claims 9 to 19, wherein the personal care composition is applied topically.

21. The method of any one of claims 9 to 20, wherein the personal care composition is applied once every hour, 2 hours, 3 hours, 6 hours or 12 hours.

22. The method according to any one of claims 9 to 21, wherein the personal care composition comprises 2% soy-derived glycopeptide.

23. The method of any one of claims 9 to 22, wherein the subject has been exposed to pollution.

24. A method for reducing the appearance of wrinkles in a subject with sensitive skin, the method comprising applying to the subject a personal care composition comprising: niacinamide, Edelweiss (Leontopodium alpinum) extract, Oryza sativa (Rice) sake lees concentrate, panthenol, and soy-derived glycopeptide.

25. The method of claim 24, wherein the personal care composition does not include any retinoid or retinoid derivative.

26. The method of any one of claims 24 to 25, wherein the personal care composition comprises, by weight of the total composition: (a) 0.1% to 10% by weight of nicotinamide, (b) 0.0001% to 10% by weight of an extract of Edelweiss (alpine edelweiss), (c) 0.001% to 10% by weight of rice (paddy rice) sake lees concentrate, (d) 0.1% to 10% by weight of panthenol, and (e) 0.001 wt% to 5 wt% of soybean-derived glycopeptide.

27. The method of any one of claims 24 to 26, wherein the personal care composition comprises, by weight of the total composition: 0.1%-4% niacinamide, 0.001%-4% edelweiss (alpine edelweiss), 0.001%-2% rice (rice) sake lees concentrate, 0.1%-3% panthenol and 0.002%-4% soy-derived glycopeptide.

28. The method according to any one of claims 24 to 27, wherein the personal care composition comprises at least one of the following: water, adenosine, humectants, photoprotective filters, antioxidants, preservatives, gelling agents, solvents, pH balancing agents and surfactants.

29. The method of claim 28, wherein the humectant comprises at least one of: Buddleja macrophylla extract, thyme extract, caprylyl glycol, glycerin, 1,2-hexanediol, and butylene glycol.

30. The method of any one of claims 24 to 29, wherein the personal care composition further comprises, by weight of the total composition: 0.01%-2% adenosine, 0.0001%-3% Buddleja oleifera extract, and 0.0001%-3% thyme extract.

31. The method of claim 29, wherein the photoprotective filter comprises at least one of zinc oxide, titanium dioxide, and iron oxide.

32. The method of any one of claims 24 to 31, wherein the personal care composition is a cream, lotion, gel, mask, serum or spray.

33. The method of any one of claims 24 to 32, wherein the personal care composition is applied topically.

34. The method of any one of claims 24 to 33, wherein the personal care composition is applied once every hour, 2 hours, 3 hours, 6 hours or 12 hours.

35. The method of any one of claims 24 to 34, wherein the personal care composition comprises 2% soy-derived glycopeptide.

36. The method of any one of claims 24 to 35, wherein the subject has been exposed to pollution.

37. A personal care composition comprising, by weight of the total composition: (a) 0.1%-10% niacinamide, (b) 0.0001% to 10% of Edelweiss (alpine edelweiss) extract, (c) 0.001% to 10% of rice (paddy rice) sake lees concentrate, and (d) 0.1%-10% panthenol.

38. The personal care composition of claim 37, further comprising: (e) 0.001%-5% soybean-derived glycopeptide.

39. A personal care composition according to any one of claims 37 to 38, wherein the personal care composition comprises, by weight of the total composition: 0.1%-4% niacinamide, 0.001%-4% edelweiss (alpine edelweiss), 0.001%-2% rice (rice) sake lees concentrate, 0.1%-3% panthenol and 0.002%-4% soy-derived glycopeptide.

40. The personal care composition of any one of claims 37 to 39, wherein the personal care composition does not comprise any retinoid or retinoid derivative.

41. A personal care composition according to any one of claims 37 to 40, further comprising at least one of the following: water, adenosine, humectants, photoprotective filters, antioxidants, preservatives, gelling agents, solvents, pH balancing agents and surfactants.

42. The personal care composition of claim 41, wherein the humectant comprises at least one of: Buddleja macrophylla extract, thyme extract, caprylyl glycol, glycerin, 1,2-hexanediol, and butylene glycol.

43. The personal care composition of any one of claims 37 to 42, further comprising, by weight of the total composition: 0.01%-2% adenosine, 0.0001%-3% Buddleja oleifera extract, and 0.0001%-3% thyme extract.

44. The personal care composition of claim 42, wherein the photoprotective filter comprises at least one of zinc oxide, titanium dioxide, and iron oxide.

45. The personal care composition of any one of claims 37 to 44, wherein the personal care composition is a cream, a lotion, a gel, a mask, a serum or a spray.

46. ​​A method for reducing pollution-induced NADPH oxidase in mitochondria in human skin, the method comprising: A composition comprising niacinamide, Leontopodium alpinum extract, Oryza sativa (Rice) sake lees concentrate, and panthenol was applied to human skin.

47. A method for reducing pollution-induced fragmentation of mitochondria in human skin, the method comprising: A composition comprising niacinamide, Leontopodium alpinum extract, Oryza sativa (Rice) sake lees concentrate, and panthenol was applied to human skin.

48. A method for reducing pollution-induced MAM production in mitochondria of human skin, the method comprising: A composition comprising niacinamide, Leontopodium alpinum extract, Oryza sativa (Rice) sake lees concentrate, and panthenol was applied to human skin.

49. A method for mitigating pollution-induced mitochondrial membrane depolarization, the method comprising: A composition comprising niacinamide, Leontopodium alpinum extract, Oryza sativa (Rice) sake lees concentrate, and panthenol was applied to human skin.

50. A method for inducing expression of procollagen and elastin in skin, the method comprising: A composition comprising niacinamide, Edelweiss (alpine leontopodium) extract, Oryza sativa (Rice) sake lees concentrate, and panthenol is topically applied to the skin, wherein the composition does not include retinol.

51. A method for reducing IL-8 and PGE-2 expression in skin, the method comprising: A composition comprising niacinamide, Edelweiss (alpine leontopodium) extract, Oryza sativa (Rice) sake lees concentrate, and panthenol is topically applied to the skin, wherein the composition does not include retinol.

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