Insecticidal composition and use thereof

Abstract

This invention belongs to the field of pesticide compound technology, specifically relating to an insecticidal composition. The active ingredients of the insecticidal composition include active ingredient A and active ingredient B, wherein active ingredient A is a compound of formula (Ⅰ), and active ingredient B is an arylisoxazoline insecticide. The mass ratio of active ingredient A to active ingredient B is 1:30 to 40:1. The compound insecticide of this invention has a significant synergistic effect, reduces the amount of insecticide used, lowers production costs and environmental risks, delays the development of insecticide resistance in pests, and can be used for integrated management of resistant pests, specifically for controlling Hemiptera, Lepidoptera, and Coleoptera pests.

Description

Technical Field

[0001] This invention belongs to the field of pesticide and insecticide technology, and particularly relates to an insecticidal composition and its application in controlling lepidopteran pests. Background Technology

[0002] Arylisoxazolines, such as fluoxazolamide and isoxazolamide, are allosteric regulators of GABA-gated chloride channels. They block activated GABA chloride channels through allosteric modification, causing over-excitation and spasms in pests, ultimately leading to death. Their mechanism of action is unique, they exhibit no cross-resistance with other insecticides, and they demonstrate high broad-spectrum activity against various Lepidoptera, Thysanoptera, and Diptera pests.

[0003] Through the inventor's compounding research, the compound shown in formula (I) was rationally compounded with aryl isoxazoline insecticides, such as oxadiazon and cyprodinil. Surprisingly, it was found that the insecticidal composition had a synergistic effect under certain mass ratios. Furthermore, the relevant reports on the compound shown in formula (I) compounded with oxadiazon and cyprodinil have not yet been published. Summary of the Invention

[0004] The purpose of this invention is to provide an insecticidal composition that has a synergistic effect, reduces drug resistance, has low cost, and has good control efficacy.

[0005] To achieve the above objectives, the technical solution adopted by the present invention is as follows: an insecticidal composition, wherein the active ingredients of the insecticidal composition include active ingredient A and active ingredient B, and active ingredient A is a compound of formula (I), with the following structural formula:

[0006] Active ingredient B is an aryl isoxazoline insecticide.

[0007] Furthermore, the aryl isoxazoline insecticide is selected from either oxadiazon or cyprodinil;

[0008] Furthermore, the mass ratio of active ingredient A to active ingredient B is 1:30 to 40:1;

[0009] Furthermore, the mass ratio of active ingredient A to active ingredient B is any value between 1:28 and 28:1 or higher;

[0010] Furthermore, the mass ratio of the compound of formula (I) to oxazolidinium is 1:30 to 22:1;

[0011] Furthermore, the mass ratio of the compound of formula (I) to oxazolidinium is 1:18 to 22:1;

[0012] Furthermore, the mass ratio of the compound of formula (I) to oxazolidinium is 1:30, 1:18, 1:9, 2:5, 3:2, 6:1, 14:1, or 22:1;

[0013] Furthermore, the mass ratio of the compound of formula (I) to oxazolidinium is 1:18, 1:9, 2:5, 3:2, 6:1, 14:1, or 22:1;

[0014] Furthermore, the mass ratio of the compound of formula (I) to cyclopropionamide is 1:28 to 40:1;

[0015] Furthermore, the mass ratio of the compound of formula (I) to cyclopropionamide is 1:28 to 28:1;

[0016] Furthermore, the mass ratio of the compound of formula (I) to cyclopropionamide is 1:28, 1:14, 1:7, 4:1, 8:1, 12:1, 28:1, or 40:1;

[0017] Furthermore, the mass ratio of the compound of formula (I) to cyclopropionamide is 1:28, 1:14, 1:7, 4:1, 8:1, 12:1, or 28:1;

[0018] Furthermore, based on a total weight of 100 wt% of the insecticidal composition, the sum of the contents of active ingredient A and active ingredient B in the insecticidal composition is 0.5 to 90 wt%.

[0019] Furthermore, based on a total weight of 100 wt% of the insecticidal composition, the sum of the contents of active ingredient A and active ingredient B in the insecticidal composition is 1 to 80 wt%.

[0020] The insecticidal composition of the present invention can be prepared by processing methods known to those skilled in the art, namely, mixing the active ingredient with a liquid solvent or a solid carrier, and then adding one or more surfactants such as wetting agents, dispersants, emulsifiers, thickeners, disintegrants, antifreeze agents, defoamers, solvents, stabilizers, penetrants and carriers.

[0021] Furthermore, the wetting agent is selected from one or more of the following: sodium dodecyl sulfate, sodium dodecylbenzene sulfonate, pull-opening powder BX, wetting and penetrating agent F, soapberry powder, silkworm excrement, or soapberry powder;

[0022] Further, the dispersant is selected from one or more of the following: polycarboxylate, lignin sulfonate, alkylphenol polyoxyethylene ether formaldehyde condensate sulfate, alkylbenzene sulfonate calcium, naphthalene sulfonate formaldehyde condensate sodium salt, alkylphenol polyoxyethylene ether phosphate salt, fatty amine polyoxyethylene ether, fatty acid polyoxyethylene ether, or glycerol fatty acid ester polyoxyethylene ether.

[0023] Furthermore, the emulsifier is selected from agricultural emulsion 500# (alkylbenzene sulfonate calcium), OP series phosphate esters (nonylphenol polyoxyethylene ether phosphate ester), 600# phosphate ester (phenylphenol polyoxyethylene ether phosphate ester), styrene polyoxyethylene ether ammonium sulfate, alkyl diphenyl ether magnesium disulfonate, triethanolamine salt, agricultural emulsion 400# (benzyl dimethylphenol polyoxyethylene ether), agricultural emulsion 700# (alkylphenol formaldehyde resin polyoxyethylene ether), Ningxia emulsion 36# (phenylethylphenol formaldehyde resin polyoxyethylene ether). The mixture consists of one or more of the following: ethyl ether, phenylethyl phenol polyoxyethylene polypropylene ether, ethylene oxide-propylene oxide block copolymer, OP series (nonylphenol polyoxyethylene ether), BY series (castor oil polyoxyethylene ether), alkyl aryl polyoxyethylene polyoxypropylene ether, Span series (sorbitan monostearate), Tween series (sorbitan fatty acid ester polyoxyethylene ether), or AEO series (fatty alcohol polyoxyethylene ether).

[0024] Furthermore, the thickener is selected from one or more of xanthan gum, polyvinyl alcohol, bentonite, carboxymethyl cellulose, or magnesium aluminum silicate;

[0025] Furthermore, the disintegrant is selected from one or more of the following: bentonite, urea, ammonium sulfate, aluminum chloride, low-substituted hydroxypropyl cellulose, lactose, citric acid, succinic acid, or sodium bicarbonate;

[0026] Furthermore, the antifreeze is selected from one or more of ethylene glycol, propylene glycol, glycerol, or urea, or a mixture thereof;

[0027] Furthermore, the defoamer is selected from silicone oil, silicone compounds, and C. 10 ~C 20 Saturated fatty acid compounds or C8-C 10 A mixture of one or more fatty alcohol compounds;

[0028] Further, the solvent is selected from one or more of the following: N,N-dimethylformamide, cyclohexanone, toluene, xylene, dimethyl sulfoxide, methanol, ethanol, trimethylcyclohexanone, N-octylpyrrolidone, ethanolamine, triethanolamine, isopropylamine, N-methylpyrrolidone, propanol, butanol, ethylene glycol, diethylene glycol, ethylene glycol methyl ether, butyl ether, ethanolamine, isopropylamine, ethyl acetate, or acetonitrile.

[0029] Furthermore, the stabilizer is selected from one or more of the following: epoxidized soybean oil, epichlorohydrin, BHT, ethyl acetate, and triphenyl phosphate;

[0030] Furthermore, the penetrant is selected from one or more of the following: penetrant JFC (fatty alcohol polyoxyethylene ether), penetrant T (diisooctyl maleate sulfonate), azone, or organosilicon;

[0031] Furthermore, the carrier is one, two, or three of the solvent or filler, and the water is preferably deionized water;

[0032] Furthermore, the filler is selected from one or more of the following: kaolin, diatomaceous earth, bentonite, attapulgite, silica, starch, or light calcium carbonate;

[0033] All of the above substances are commercially available.

[0034] The insecticidal composition of the present invention can be processed into any agriculturally acceptable formulation;

[0035] Furthermore, the insecticidal composition can be prepared into an agriculturally permissible formulation, wherein the formulation is selected from solid and / or liquid formulations;

[0036] Furthermore, the solid dosage forms include powders, granules, balls, tablets, strips, wettable powders, oil-dispersible powders, emulsion powders, water-dispersible granules, emulsion granules, water-dispersible tablets, soluble powders, soluble tablets, or soluble granules;

[0037] Furthermore, the liquid formulation includes soluble agents, colloids, oils, spreading oils, emulsions, latexes, dispersible liquids, ointments, water emulsions, oil emulsions, microemulsions, lipids, suspensions, microcapsule suspensions, oil suspensions, dispersible oil suspensions, suspensions, microcapsule suspension-suspensions, microcapsule suspension-water emulsions, or microcapsule suspension-suspension emulsions;

[0038] Furthermore, the solid dosage form is selected from wettable powders and water-dispersible granules; the liquid dosage form is selected from emulsifiable concentrates, water-in-oil emulsions, microemulsions, suspensions, suspension emulsions, and dispersible oil suspensions.

[0039] Furthermore, the solid formulation is selected from wettable powders and water-dispersible granules; the liquid formulation is selected from emulsifiable concentrates and suspensions.

[0040] The present invention also provides the application of the insecticidal composition described above in the control of lepidopteran pests;

[0041] Furthermore, the aforementioned lepidopteran pests include: *Adoxophyes spp.*, *Adoxophyes orana*, *Agrotis spp.* (root cutter), *Agrotis ipsilon* (black cutworm), *Alabama argillacea* (cotton leafworm), *Amorbia cuneana*, *Amyelosis transitella* (navelorange worm), *Anacamptodes defectaria*, *Anarsia lineatella* (peach twig borer), *Anomis sabulifera* (jute looper), *Antica rsia g emma ta lis*, *Archi ps argyrospila* (fruittree leafroller), and *Archips rosana* (rose leafroller). Leaf rollers, *Argyrotaenia* spp. (tortricid moths), *Argyrotaenia citrana* (orange tortrix), *Autographa gamma*, *Bonagota cranaodes*, *Borbo cinnara* (rice leaf folder), *Bucculatrix thurberiella* (cotton leafperforator), *Caloptilia* spp. (leaf miners), *Ca pua reticulana*, *Carposina niponensis* (peach fruit moth), *Chilo* spp., *Chlumetia transversa* (mango shoot borer), *Choristoneurarosaceana* (obliquebanded rose leaf roller)

[0042] Leafroller), noctuid moth (Chrysodeixis spp.), rice leaf roller (Cnaphalocerus medinalis) (grass

[0043] Leafroller, Colias spp., Conpomorphacramerella, Cossus cossus (carpenter moth), Crambus spp. (soil webworms), Cydiafunebrana (plumfruit moth), Cydia molesta (oriental fruit moth), Cydianignicana (pea moth), Cydia pomonella (codling moth), Darna diducta, Diaphania spp. (stem borers), Diatraea spp. (stalk borers), Diatraea spp. (stalk borers), Diatraea saccharalis (sugarcaneborer), Diatraea graniosella (southwester cornborer), Earias spp. (cotton bollworm), Earias insulata (Egyptian cotton bollworm), Earias vitella (rough northern bollworm), Ecdytopophaaurantianum, Elasmopalpus lignosellus (lesser corn stalk borer), Epiphysias postruttana (light brown applemoth), Ephestia spp. (flour moths), Ephestia cautella (almond moth), Ephestia elutella (tobbaco moth) Mediterranean flour moth (Ephestia kuehniella) and species of the genus Epimeces (Epimeces spp.).), Epinotia aporema, Erionota thrax (bananaskipper), Eupoecilia ambiguella (grape berry moth), Euxoa auxiliaris (army cutworm), Feltia spp. (root cutter), Gortyna spp. (stemborers), Grapholita molesta (Oriental fruit borer).

[0044] (oriental fruit moth)), Hedylepta indicate (bean leaf webber), Helicoverpa sp p. (noctus moth), Helicoverpa armigera, Helicoverpa zea, Heliothis spp., Heliothis virescens, Hellula undalis (cabbage webworm), Indarbela spp. (root borers), Keiferia lycopersicella, Leucinodes orbonalis, Leucoptera malifoliella, Lithocollectis spp., Lobesia botrana (grape fruit moth) The following species are listed: fruitmoth, Loxagrotis spp., Loxagrotis albicosta (western bean cutworm), Lymantria dispar (gypsy moth), Lyonetia clerkella (apple leaf miner), Mahasena corbetti (oil palm bagworm), and Malacosoma spp.(tent caterpillars), cabbage armyworm (Mamestra brassicae), bean pod borer (Maruca testulalis), bagworm (Metisa plana), true armyworm (Mythimna unipuncta), elegantalis (Neoleucinodes elegantalis), depunctalis (Nymphula depunctalis), winter inchworm (Operophtherabrumata), European corn borer (Ostrinia nubilalis), Oxydiavesulia, common currant tortrix (Pandemis cerasana), brown apple tortrix (Pandemis heparana), African swallowtail butterfly (Papilio demodocus), pink bollworm (Pectinophora gossypiella). The following species are listed: bollworm, Peridroma saucia (variegated cutworm), Perileucoptera coffeella (white coffee leafminer), Phthorimaea operculella (potato tuber moth), Phylloocnisitis citrella (citrus leafminer), Phyllonorycter spp. (leek moth), Pieris rapae (cabbage white butterfly), Plathapena scabra (alfalfa green armyworm), Plodia interpunctella (Indian grain moth), Plutellaxylostella (diamondback moth), Polychrosis viteana (grape leafroller), Prays endocarpa (citrus fruit borer), and Prays endocarpa (olive borer). oleae (olive moth), species of the genus Pseudaletia (Pseudaletia spp.).(Noctus), Pseudaletia unipunctata (armyworm), soybean noctus (Pseudoplusia includes), inchworm (Rachiplusia nu), rice stem borer (Scirpophaga incertulas), stem borer (Sesamia spp.) (stemborers), rice stem borer (Sesamia inferens) (pink rice stem borer), rice stem borer (Sesamia nonagrioides), copper-spotted brown tussock moth (Setora nitens), wheat moth (Sitotroga cerealella) (Angoumois grain moth), grape long-bearded leafroller (Sparganothis pilleriana), beet armyworm (Spodoptera spp.), beet armyworm (Spodoptera exigua), fall armyworm (Spodoptera fugiperda), southern beet armyworm (Spodoptera oridania) (southern noctus) The genus Synanthedon includes *Thecla basilides*, *Thermisia gemmatalis*, *Tineola bisselliella* (webbing clothes moth), *Trichoplusia ni* (cabbage caterpillar), and *Tutaabsoluta* (tomato leafminer).

[0045] Furthermore, the lepidopteran pests include diamondback moth, beet armyworm, cotton bollworm, fall armyworm, rice stem borer, cotton bollworm, and cabbage caterpillar;

[0046] The present invention also provides an insecticidal composition as described above, applied in an effective dose to the pest that needs to be controlled or to the medium in which it grows.

[0047] The beneficial effects of this invention are as follows:

[0048] 1) The insecticidal composition of the present invention has a synergistic effect on the control of lepidopteran pests when formulated in a certain mass ratio;

[0049] 2) Significantly reduces pesticide use and delays the development of resistance to single-agent pesticides in lepidopteran pests;

[0050] 3) It reduces environmental pollution and ensures the safety of people and animals. Detailed Implementation

[0051] The present invention will be further described below with reference to the embodiments. The percentages in the embodiments are all weight percentages, but the present invention is not limited thereto.

[0052] The insecticidal composition of the present invention can be provided in formulation form. It can be formulated as a suspension concentrate, water-dispersible granules, wettable powder, dispersible oil suspension, etc., as needed. The content of the active ingredient in the composition of the present invention depends on the application rate when used alone, as well as on the mixing ratio and the degree of synergistic effect. The optimal range of active ingredient content varies depending on the formulation type of the composition.

[0053] Formulation preparation example

[0054] Preparation Example 1:

[0055] 42% Formula (I) Compound·Oxadiazon Water Dispersible Granules (24:18)

[0056] Formulation: Compound (I) 24%, oxazolidinium 18%, sodium lignosulfonate 7%, naphthalenesulfonate formaldehyde condensate 7%, sodium dodecyl sulfate 2.5%, silica 7%, starch 10%, kaolin to make up the balance;

[0057] Preparation method: According to the formulation ratio in the example, the active ingredient is added to the carrier, and surfactants and other functional additives are added thereto. After mixing, the mixture is pulverized by air jet and 10-25% water is added. Then, the mixture is kneaded, granulated, dried and sieved to obtain the water-dispersible granule product.

[0058] Preparation Example 2:

[0059] 46% Formula (I) Compound·Oxadiazon wettable powder (26:20)

[0060] Formulation: 26% of compound (I), 20% of oxazolidinium, 4.5% of alkyl naphthalene sulfonate (Morwet EFW), 4% of block copolymer dispersant D-800, 3% of sodium alkyl polyoxyethylene ether sulfonate, 5.5% of sodium lignin sulfonate, and kaolin to make up the balance;

[0061] Preparation method: The active ingredients, other functional additives and fillers are mixed according to the formula ratio, stirred evenly in a stirring tank, and then pulverized and mixed evenly multiple times by an air jet mill to prepare the wettable powder of the composition of the present invention.

[0062] Preparation Example 3:

[0063] 36% Formula (I) Compound·Cyprofloxacin Wettable Powder (28:8)

[0064] Formulation: 28% of compound (I), 8% of cyclopropionate flufenoxuron, 4.5% of alkyl naphthalene sulfonate (Morwet EFW), 4% of block copolymer dispersant D-800, 3% of sodium alkyl polyoxyethylene ether sulfonate, 6.5% of starch, and kaolin to make up the balance;

[0065] Preparation method: Same as in preparation example 2.

[0066] Preparation Example 4:

[0067] 25% Formula (I) compound·Cyprofloxacin suspension (20:5)

[0068] Formulation: 20% of compound (Ⅰ), 5% of cyclopropionamide, 3.5% of polyether, 3% of phenethylphenol polyether phosphate salt, 1.5% of naphthalene sulfonate (2020), 2% of sodium dioctyl succinate sulfonate, 1.1% of magnesium aluminum silicate, 0.25% of xanthan gum, 4.5% of glycerol, 0.02% of benzisothiazolinone, 0.5% of organosilicon defoamer, and deionized water to make up the balance;

[0069] Preparation method: According to the formula ratio, the active ingredients, surfactants and other functional additives are placed in the reaction vessel in sequence, water is added and mixed evenly, and then subjected to high-speed shearing, wet sand milling and finally homogenized filtration to obtain the suspension.

[0070] Preparation Example 5:

[0071] 30% Formula (I) compound·Oxadiazon suspension (20:10)

[0072] Formulation: 20% of compound (Ⅰ), 10% of oxadiazon, 3.5% of polyether, 3% of phenethylphenol polyether phosphate salt, 1% of naphthalene sulfonate (2020), 2% of sodium dioctyl succinate sulfonate, 1.1% of magnesium aluminum silicate, 0.2% of xanthan gum, 5% of ethylene glycol, 0.02% of benzisothiazolinone, 0.5% of organosilicon defoamer, and deionized water to make up the balance;

[0073] Preparation method: Same as in preparation example 4.

[0074] Preparation Example 6:

[0075] 10% Formula (I) Compound·Cyprofen dispersible oil suspension (8:2)

[0076] Formulation: 8% of compound (Ⅰ), 2% of cyclopropionate flufenoxuron, 2% of succinate sulfonate, 12% of alkyl aryl polyoxyethylene polyoxypropylene ether, 3% of fatty alcohol polyoxyethylene ether, 3% of calcium dodecylbenzene sulfonate, 1.5% of silica, 0.5% of organobentonite, 15% of 200# solvent oil, and methyl oleate to make up the balance.

[0077] Preparation method: According to the formula ratio, the active ingredients, surfactants and other functional additives are placed in the reaction vessel in sequence, solvent oil is added and mixed evenly, and then subjected to high-speed shearing, wet sand milling and finally homogenization filtration to obtain the dispersible oil suspension product.

[0078] Indoor bioactivity assay:

[0079] The specific experimental method is as follows:

[0080] Lepidoptera larvae: A combination of leaf soaking and insect soaking;

[0081] Test insect age: A sensitive population that has been raised indoors for multiple generations was used, and healthy, uniform second-instar lepidopteran larvae were selected (no less than 60 per treatment).

[0082] Use tweezers to immerse fresh cabbage slices in the solution for 10 seconds, then remove them and let the solution air dry naturally. Place the cabbage slices in a petri dish lined with moisturizing filter paper, immerse the test insects in the solution for 5 seconds, absorb the excess solution with filter paper, and then place the test insects into a petri dish with leaves soaked in the appropriate concentration.

[0083] Each treatment was repeated four times, with a blank treatment serving as a control. The treated insects were then reared in an AI-controlled culture room at 26±1℃, with a light duration of L:D = 16h:8h and a relative humidity of 60%.

[0084] The mortality of test insects was investigated 48 hours after treatment with the pesticide. The criteria for judging the mortality of test insects were obvious shrinkage of the insect body or inability to crawl normally when punctured. The number of dead insects was recorded.

[0085] Data statistics and analysis:

[0086] Based on the survey data, the corrected mortality rate for each treatment was calculated using the following formula:

[0087]

[0088] In the formula:

[0089] P – Mortality rate, expressed as a percentage (%);

[0090] K represents the number of dead insects, in heads;

[0091] N represents the total number of insects treated, in units of heads.

[0092]

[0093] In the formula:

[0094] P1 – Corrected mortality rate, in percentage (%);

[0095] P t—The mortality rate is expressed as a percentage (%).

[0096] P0 – Mortality rate in the blank control group, expressed as a percentage (%).

[0097] Data statistics and analysis: If the control mortality rate is <5%, no correction is needed; if the control mortality rate is between 5% and 20%, correction should be performed; if the control mortality rate is >20%, the trial needs to be repeated.

[0098] The data were processed using probability value analysis; the DPS statistical analysis system was used to analyze the data and determine the toxicity regression line and LC. 50 The values, their 95% confidence limits, and correlation coefficients r are used to evaluate the activity of the test reagent on the biological sample.

[0099] The co-toxicity coefficient (CTC value) of the mixture is calculated using the following formula:

[0100]

[0101] In the formula:

[0102] ATI – Actual Measured Toxicity Index of Mixtures;

[0103] S – LC50 of standard insecticides 50 The unit is milligrams per liter (mg / L);

[0104] M – LC of the mixture 50 The unit is milligrams per liter (mg / L).

[0105] TTI = TI A *P A +TI B *P B

[0106] In the formula:

[0107] TTI – Theoretical Toxicity Index of Mixtures;

[0108] TI A —A. Toxicity index of drug A;

[0109] P A —Percentage content of drug A in the mixture, expressed as percentage (%);

[0110] TI B —Toxicity index of drug B;

[0111] P B —Percentage content of agent B in the mixture, expressed as percentage (%).

[0112]

[0113] In the formula:

[0114] CTC – Cotoxicity Coefficient;

[0115] ATI – Actual Measured Toxicity Index of Mixtures;

[0116] TTI – Theoretical Toxicity Index of Mixtures.

[0117] The co-toxicity coefficient of the compound is ≥120, which shows a synergistic effect; CTC≤80 shows an antagonistic effect; and 80<CTC<120 shows an additive effect.

[0118] Indoor activity assay of cabbage caterpillar

[0119] Table 1 shows that oxadiazon has high toxicity to cabbage caterpillars, and its LC50 is... 50 The LC50 of compound (I) against cabbage caterpillars was 2.446 mg / L. 50 It was 12.726 mg / L.

[0120] When the weight ratio of compound (I) to oxazolidinium is 1:30 to 22:1, the co-toxicity coefficient of the two compounds is greater than 80, and the two compounds exhibit an additive or synergistic effect within this weight ratio range. When the weight ratio of compound (I) to oxazolidinium is 1:18 to 22:1, the co-toxicity coefficient of the two compounds is greater than 120, and the two compounds exhibit a synergistic effect within this weight ratio range.

[0121] Table 1 shows the toxicity test results of compound (I) combined with oxazolidinone on cabbage caterpillars.

[0122]

[0123] Table 2 shows that cyclopropionamide has high toxicity to cabbage caterpillars, and its LC50... 50 The LC50 of compound (I) against cabbage caterpillars was 1.051 mg / L. 50 It was 12.726 mg / L.

[0124] When the weight ratio of compound (I) to cycloflufenicol was 1:28 to 40:1, the co-toxicity coefficient of the mixture was greater than 80, showing an additive or synergistic effect, without any antagonistic effect. When the weight ratio of compound (I) to cycloflufenicol was 1:28 to 28:1, the co-toxicity coefficient of the mixture was greater than 120, indicating that the mixture of the two showed a synergistic effect within this weight ratio range.

[0125] Table 2 shows the toxicity test results of compound (I) combined with cyprofenoflavone on cabbage caterpillars.

[0126]

[0127] Field trials for the control of cabbage caterpillars

[0128] Experimental crop: Chinese cabbage (Chengza No. 5);

[0129] Experimental target: cabbage caterpillar;

[0130] Test reference: Based on GB / T 17980.13-2000 "Field Efficacy Test Guidelines (I): Insecticide Control of Lepidoptera Larvae in Cruciferous Vegetables";

[0131] Experimental location: Xiazhuang Chinese cabbage experimental field, Chengyang District, Qingdao City, Shandong Province;

[0132] Application equipment: 3WBS-16 backpack electric sprayer;

[0133] Test date: August 12, 2023;

[0134] Experimental environment: The experimental site was flat, with loam soil, and the plot management level, soil fertility and irrigation conditions were consistent.

[0135] Test reagents:

[0136] Table 3 Field Trial Design and Pesticide Dosage

[0137]

[0138]

[0139] Weather: Sunny on the day of application, and sunny or cloudy for 7 days after application.

[0140] Other: The cultivation and water and fertilizer conditions in each plot were uniform and consistent, and no fungicides, insecticides and herbicides were used in the 30 days prior to the experiment.

[0141] Experimental method: Apply the pesticide once during the peak occurrence period of cabbage caterpillars (mostly in the 2nd to 4th instar).

[0142] Cell size and duplication: randomized block arrangement, cell size 20m² 2 Each treatment was repeated 4 times.

[0143] Survey method: Five random sampling points were taken in each area, and four plants were fixed at each point with tags. The number of cabbage caterpillars on all Chinese cabbage plants was investigated. The initial number of caterpillars was investigated before the pesticide was applied, and the number of residual caterpillars was investigated 3 days and 10 days after the pesticide was applied.

[0144] Calculation formulas and data analysis:

[0145]

[0146] Experimental results:

[0147] Safety: During the trial period and later observations, the Chinese cabbage grew normally, and no obvious pesticide damage or other adverse phenomena occurred.

[0148] As can be seen from Table 4, 3 days after application, 30% compound (I)·oxazolidinium suspension (20:10) and 36% compound (I)·cyprodinium wettable powder (28:8) showed good rapid efficacy against cabbage caterpillars, with control efficacies of 89.16% and 86.87%, respectively, which were significantly higher than their control single agents.

[0149] Table 4. Field control efficacy of different pesticides against cabbage caterpillars in Chinese cabbage (3 days after application)

[0150]

[0151] Note: The above data on insect population size and control efficacy are the average of four replicates, and the values ​​are rounded to two decimal places. Different letters after the control efficacy data in the same column indicate significant differences (P < 0.05).

[0152] As shown in Table 5, 10 days after application, 30% compound (I)·oxazolidinium suspension (20:10) and 36% compound (I)·cyprodinium wettable powder (28:8) showed good residual efficacy against cabbage caterpillars, with control efficacies of 94.64% and 93.25%, respectively, which were significantly higher than their control single agents.

[0153] Table 5. Field control efficacy of different pesticides against cabbage caterpillars in Chinese cabbage (10 days after application)

[0154]

[0155] Note: The above data on insect population size and control efficacy are the average of four replicates, and the values ​​are rounded to two decimal places. Different letters after the control efficacy data in the same column indicate significant differences (P < 0.05).

[0156] Although this application describes specific embodiments in detail with the aid of examples, the disclosure of this application can be modified and substituted in various ways. However, it should be understood that the disclosure of this application is not limited to the specific form disclosed. Rather, the disclosure of this application covers all modifications, equivalents, and substitutions within the scope of the disclosure of this application, the scope of which is defined by the appended claims and their legal equivalents.

Claims

1. An insecticidal composition, characterized by comprising, The insecticidal composition comprises active ingredient A and active ingredient B. Active ingredient A is a compound of formula (I) with the following structural formula: Equation (I); Active ingredient B is oxazolidinium and cyclopyralidium, and the mass ratio of the compound of formula (I) to oxazolidinium is 1:18 to 22:1, and the mass ratio of the compound of formula (I) to cyclopyralidium is 1:28 to 28:

1.

2. The insecticidal composition according to claim 1, characterized in that, The mass ratio of the compound of formula (I) to oxazolidinium is 1:18, 1:9, 2:5, 3:2, 6:1, 14:1, 22:1, and the mass ratio of the compound of formula (I) to cyclopyridaben is 1:28, 1:14, 1:7, 4:1, 8:1, 12:1, 28:

1.

3. The insecticidal composition according to claim 1, characterized in that, Based on a total weight of 100 wt% of the insecticidal composition, the sum of the contents of active ingredient A and active ingredient B in the insecticidal composition is 0.5 to 90 wt%.

4. The insecticidal composition according to claim 3, characterized in that, Based on a total weight of 100 wt% of the insecticidal composition, the sum of the contents of active ingredient A and active ingredient B in the insecticidal composition is 1 to 80 wt%.

5. The insecticidal composition according to claim 1, characterized in that, The insecticidal composition further includes adjuvants selected from one or more of wetting agents, dispersants, emulsifiers, thickeners, disintegrants, antifreeze agents, defoamers, solvents, stabilizers, penetrants, and carriers.

6. The insecticidal composition according to claim 5, characterized in that, The insecticidal composition is prepared into an agriculturally permissible formulation, wherein the formulation is selected from wettable powder, water-dispersible granules, suspension concentrate, or dispersible oil suspension.

7. The use of the insecticidal composition according to any one of claims 1-6 in the control of phytophagous pests in agriculture, forestry, or horticulture, characterized in that, The phytophagous pest mentioned is the cabbage caterpillar.

8. The application as described in claim 7, characterized in that, The insecticidal composition is applied in an effective dose to the pest that needs to be controlled or to the medium in which it grows.

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