Traditional Chinese medicine formula for treating cold-wrapped fire syndrome caused by respiratory virus infection

Abstract

The invention belongs to the technical field of traditional Chinese medicine, and discloses a traditional Chinese medicine formula for treating respiratory virus infection cold-wrapped fire syndrome, which is prepared from the following raw material medicines in parts by weight: 20-40 parts of gypsum, 10-20 parts of mint, 10-20 parts of periostracum cicada, 5-15 parts of raw liquorice, 10-20 parts of scutellaria baicalensis, 5-15 parts of coptis chinensis, 10-20 parts of fructus forsythiae, 10-20 parts of honeysuckle flower and 5-15 parts of platycodon grandiflorum. According to the traditional Chinese medicine formula, medicine particles are prepared in advance through the steps of decoction, concentration, drying and powder preparation and are prepared into bags; the traditional Chinese medicine formula is applied to preparation of medicines for treating, pre-treating or prognosing the cold-wrapped-fire syndrome heat toxin of respiratory virus infection; the traditional Chinese medicine formula is used for treating respiratory virus infection early-stage cold-wrapped fire syndrome heat toxin patients, related symptoms can be effectively relieved, meanwhile, disease prognosis is improved, and aggravation of the disease can be effectively avoided.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicines, and in particular to a traditional Chinese medicine formula for treating cold-enclosed-fire syndrome of respiratory viral infection. Background Art

[0002] Since the 1970s, the World Health Organization has found that new infectious diseases emerge almost every year around the world, among which viral diseases are the main type. The respiratory tract is the most common site of viral invasion. Statistics show that 70%-80% of the pathogenic microorganisms in upper respiratory tract infections are viruses, and about 61% of the lower respiratory tract infections are viruses. With the changes in society and the natural environment, as well as the continuous mutation of viruses, new respiratory viral infections may continue to emerge, causing great impacts on public health, social stability and the national economy.

[0003] For respiratory viral infections, early identification, early intervention, and blocking of transmission are the key to reducing severe illness and mortality. Due to their structural characteristics, common RNA viruses such as influenza virus, syncytial virus, and coronavirus will conceal their own identifiable RNA replicas after infecting the host, resulting in immune escape, which in turn causes massive viral replication and aggravates the infection. Therefore, in the early stages of infection, how to accurately identify the key links in the progression of the disease, conduct timely treatment intervention, and avoid the disease from becoming severe is the focus of preventing and treating severe respiratory viral infections. At present, clinical practice lacks sufficient attention to the early stages of respiratory viral infections, and there are no biomarkers or clinical evaluation technologies related to the severity of respiratory viral infections. At the same time, the treatment of early respiratory viral infections is mainly conventional treatment, which is usually unable to effectively relieve the patient's clinical symptoms.

[0004] According to traditional Chinese medicine, respiratory viral infection belongs to the category of "epidemic disease" and "exogenous febrile disease". For the early stage of respiratory viral infection, the relevant diagnosis and treatment schemes of traditional Chinese medicine include wind-cold, wind-heat, summer-dampness, qi deficiency, yang deficiency and other syndromes. In addition to the above common syndromes, cold-encapsulated fire syndrome is also a common syndrome of respiratory viral infection, especially in the winter and spring influenza season, which is more common. This is the deficiency of the current diagnosis and treatment schemes related to respiratory viral infection. Professor Qi Wensheng of the Emergency Department of Guang'anmen Hospital combined decades of clinical observation and data statistics and believed that cold-encapsulated fire syndrome objectively exists in respiratory viral infection, and proposed that cold-encapsulated fire syndrome is a specific syndrome that forms typical viral pneumonia or causes the disease to worsen in the early stage of respiratory viral infection. It was further found that patients with cold-encapsulated fire syndrome can be divided into those with external cold and those with heat toxicity according to different constitutions and stages of the disease. For the first time, the treatment scheme of "those with external cold as the main symptoms are given Chai Ge Qing San Fang, and those with heat toxicity as the main symptoms are given Jie Du Qing Wen Fang" was proposed, and its definite effectiveness and safety were confirmed through clinical observation. Summary of the invention

[0005] The present invention aims to provide a traditional Chinese medicine formula for treating the cold-enclosing-fire syndrome of respiratory viral infection. The traditional Chinese medicine formula can be used to treat patients with the cold-enclosing-fire syndrome with a tendency to heat toxicity in the early stage of respiratory viral infection, effectively alleviate related symptoms, improve the prognosis of the disease, and effectively avoid aggravation of the disease.

[0006] In order to achieve the above object, the present invention provides the following technical solutions:

[0007] A traditional Chinese medicine formula for treating respiratory viral infection cold-enclosed-fire syndrome, the traditional Chinese medicine formula comprising the following raw materials in the following weight proportions:

[0008] 20-40 parts of gypsum, 10-20 parts of mint, 10-20 parts of cicada shells, 5-15 parts of raw liquorice, 10-20 parts of scutellaria, 5-15 parts of coptis, 10-20 parts of forsythia, 10-20 parts of honeysuckle, and 5-15 parts of platycodon.

[0009] Furthermore, the Chinese medicine formula is composed of the following raw materials in the following weight proportions:

[0010] 30 parts of gypsum, 12 parts of mint, 15 parts of cicada shells, 10 parts of raw liquorice, 15 parts of scutellaria, 10 parts of coptis, 15 parts of forsythia, 15 parts of honeysuckle, and 10 parts of platycodon.

[0011] The preparation method of the above-mentioned traditional Chinese medicine formula for treating respiratory viral infection cold-enclosed-fire syndrome comprises the following steps:

[0012] S1. Preparation of API

[0013] Selection and cleaning: First, select the APIs to remove impurities, non-medicinal parts, and damaged or deteriorated APIs; then clean the APIs to remove dust and dirt on the surface;

[0014] Cutting and crushing: Cutting or crushing the API according to its characteristics and requirements;

[0015] S2. Decoction

[0016] Soaking: Put the API prepared in step S1 into a container and add clean water to soak for 30-60 minutes to allow the API to fully absorb water and swell;

[0017] Decoction: Put the soaked raw materials and water into the decoction pot, heat until boiling, then turn to low heat and continue to decoct; and control the decoction time and heat according to the properties of the medicinal materials and the required efficacy;

[0018] Combined decoction: Combine the medicinal liquids obtained from multiple decoctions to form a decoction;

[0019] S3, Concentration

[0020] Filtration: Filter the combined decoction to remove impurities and suspended matter;

[0021] Concentration: Concentrate the filtered decoction and remove excess water by heating and evaporation;

[0022] S4. Drying

[0023] Use spray drying or vacuum drying to remove water from the drug solution while maintaining the active ingredients and efficacy of the drug solution;

[0024] S5. Configuration and packaging

[0025] According to the mass ratio of the raw materials, various Chinese medicine powders are mixed together to prepare an oral dosage form, and the mixture is packaged to obtain the required Chinese medicine formula.

[0026] Furthermore, in step S5, the configured oral dosage form is one of granules, oral liquid, powder, tablet, capsule, and pill.

[0027] Furthermore, the prepared oral dosage form is a granule and is packaged into bags.

[0028] The above-mentioned traditional Chinese medicine formula for treating respiratory viral infection with cold-enclosing-fire syndrome is used in the preparation of treatment, prognosis or prognosis of respiratory viral infection with cold-enclosing-fire syndrome with a tendency towards heat toxicity.

[0029] The principle and beneficial effects of the technical solution are:

[0030] Gypsum: sweet, pungent, very cold; Functions and indications: clearing away heat and purging fire, relieving restlessness and quenching thirst. Used for exogenous febrile diseases, high fever and thirst, lung heat and cough, hyperactivity of stomach fire, headache, and toothache.

[0031] Peppermint: pungent, cool; Functions and indications: dissipate wind-heat, clear the head and eyes, and relieve rash. Used for wind-heat cold, initial onset of wind-heat, headache, red eyes, throat paralysis, mouth sores, rubella, measles, chest and flank distension.

[0032] Cicada skin: sweet, cold; Functions and indications: dissipate wind and heat, relieve sore throat, clear rash, remove cataracts, relieve spasms. Used for wind-heat cold, sore throat, hoarseness, measles that do not clear up, itchy rubella, red eyes and cataracts, convulsions, and tetanus.

[0033] Raw Licorice: sweet, neutral; Functions and indications: tonifying the spleen and replenishing Qi, clearing away heat and detoxifying, removing phlegm and relieving cough, relieving pain, and harmonizing various medicines. It is used for spleen and stomach weakness, fatigue, palpitations and shortness of breath, cough with sputum, abdominal and limb cramps and pain, carbuncle, sore and ulcer, and relieving drug toxicity and potency.

[0034] Scutellaria baicalensis: bitter, cold; Functions and indications: clearing away heat and dampness, purging fire and detoxifying, stopping bleeding, and calming the fetus. It is used for damp-heat, chest tightness and nausea due to summer heat, damp-heat fullness, diarrhea, jaundice, lung heat cough, high fever and thirst, vomiting and bleeding due to blood heat, carbuncle, sore and toxicity, and restless fetus.

[0035] Coptis chinensis: bitter, cold; Functions and indications: clearing away heat and dampness, purging fire and detoxifying. Used for damp-heat fullness, vomiting and acid regurgitation, diarrhea, jaundice, high fever and coma, hyperactivity of heart fire, restlessness and insomnia, vomiting and bleeding due to blood heat, red eyes, toothache, thirst, carbuncle, furuncle; external treatment of eczema, wet sores, pus in the ear canal.

[0036] Forsythia: bitter, slightly cold; Functions and indications: clearing away heat and detoxifying, reducing swelling and dispersing nodules. Used for carbuncle, scrofula, breast carbuncle, erysipelas, wind-heat cold, initial stage of febrile disease, warm and hot entering the Ying, high fever, thirst, coma and rash, and heat stranguria and urinary retention.

[0037] Honeysuckle: sweet, cold; Functions and indications: clearing away heat and detoxifying, cooling and dispersing wind-heat. Used for carbuncle, furuncle, throat paralysis, erysipelas, dysentery caused by heat toxins, wind-heat cold, and fever caused by febrile diseases.

[0038] Platycodon grandiflorum: bitter, pungent, neutral; Functions and indications: clearing the lungs, relieving sore throat, removing phlegm, and draining pus. Used for cough with a lot of phlegm, chest tightness, sore throat, hoarseness, lung abscess with pus, and sores with pus that do not break.

[0039] The Chinese medicine formula provided by the present invention is mainly used to treat early-stage exogenous cold-fire syndrome with heat toxicity as the main symptom, and the clinical manifestations are mainly high fever, sore throat, cough with yellow sticky sputum, dry mouth, flushed face, yellow urine, sticky or dry stool and the like.

[0040] This Chinese medicine formula is designed for the treatment of early-stage respiratory viral infection with cold-encompassing fire syndrome and heat toxicity. It can effectively relieve related symptoms, while improving the prognosis of the disease and avoiding worsening of the disease that causes further damage to the patient's health and increased treatment costs. Moreover, this Chinese medicine formula is simple to use, suitable for a wide range of people, and can be widely promoted and applied in clinical practice. DETAILED DESCRIPTION

[0041] The present invention is further described in detail below in conjunction with embodiments:

[0042] A traditional Chinese medicine formula for treating respiratory viral infection cold-enclosed-fire syndrome, the traditional Chinese medicine formula comprising the following raw materials in the following weight proportions:

[0043] 20-40 parts of gypsum, 10-20 parts of mint, 10-20 parts of cicada shells, 5-15 parts of raw liquorice, 10-20 parts of scutellaria, 5-15 parts of coptis, 10-20 parts of forsythia, 10-20 parts of honeysuckle, and 5-15 parts of platycodon.

[0044] Furthermore, the Chinese medicine formula is composed of the following raw materials in the following weight proportions:

[0045] 30 parts of gypsum, 12 parts of mint, 15 parts of cicada shells, 10 parts of raw liquorice, 15 parts of scutellaria, 10 parts of coptis, 15 parts of forsythia, 15 parts of honeysuckle, and 10 parts of platycodon.

[0046] The preparation method of the above-mentioned traditional Chinese medicine formula for treating respiratory viral infection cold-enclosed-fire syndrome comprises the following steps:

[0047] S1. Preparation of API

[0048] Selection and cleaning: First, select the APIs to remove impurities, non-medicinal parts, and damaged or deteriorated APIs; then clean the APIs to remove dust and dirt on the surface;

[0049] Cutting and crushing: Cutting or crushing the API according to its characteristics and requirements;

[0050] S2. Decoction

[0051] Soaking: Put the API prepared in step S1 into a container and add clean water to soak for 30-60 minutes to allow the API to fully absorb water and swell;

[0052] Decoction: Put the soaked raw materials and water into the decoction pot, heat until boiling, then turn to low heat and continue to decoct; and control the decoction time and heat according to the properties of the medicinal materials and the required efficacy;

[0053] Combined decoction: Combine the medicinal liquids obtained from multiple decoctions to form a decoction;

[0054] S3, Concentration

[0055] Filtration: Filter the combined decoction to remove impurities and suspended matter;

[0056] Concentration: Concentrate the filtered decoction and remove excess water by heating and evaporation;

[0057] S4. Drying

[0058] Use spray drying or vacuum drying to remove water from the drug solution while maintaining the active ingredients and efficacy of the drug solution;

[0059] S5. Configuration and packaging

[0060] According to the mass ratio of the raw materials, various Chinese medicine powders are mixed together to prepare an oral dosage form, and the mixture is packaged to obtain the required Chinese medicine formula.

[0061] Furthermore, the prepared oral dosage form is one of granules, oral liquid, powder, tablet, capsule, and pill.

[0062] Furthermore, the prepared oral dosage form is a granule and is packaged into bags.

[0063] The above-mentioned traditional Chinese medicine formula for treating respiratory viral infection with cold-enclosing-fire syndrome is used in the preparation of treatment, prognosis or prognosis of respiratory viral infection with cold-enclosing-fire syndrome with a tendency towards heat toxicity.

[0064] Example 1

[0065] Take 30g of raw gypsum, 12g of mint, 15g of cicada shell, 10g of raw licorice, 15g of scutellaria, 10g of coptis, 15g of forsythia, 15g of honeysuckle, and 10g of platycodon. Prepare the medicine into granules through the steps of decoction-concentration-drying-powdering, and prepare into bags. For patients with cold-encircling-fire syndrome and heat-toxicity, add a small amount of warm water when taking the medicine. Generally, take it twice a day. In severe cases, it can be taken four times a day for a short period of time.

[0066] Example 2

[0067] Xu XX, male, 24 years old. First diagnosis: low fever with sore throat for 1 day. The patient had fever without obvious cause 1 day ago, Tmax: 37.9℃, with sore throat, cough and sputum, a little yellow sputum, check for influenza (+), and no abnormalities in blood routine. Now: fever, T: 37.7℃, sore throat like a knife, slight aversion to cold, with cough and sputum, not much sputum, headache, occasional chest tightness and breath holding, good appetite and sleep, regular stool, yellow urine. The clinical symptom score is 13 points. Five doses of the Chinese medicine formula of the present invention were given. The patient had no fever, sore throat was relieved, cough was relieved, and the clinical symptom score was 3 points during the second diagnosis.

[0068] Example 3

[0069] Wang XX, male, 23 years old. First diagnosis: fever with cough and sore throat for 1 day. The patient had fever without obvious cause 1 day ago, self-tested influenza A antigen was positive, T: 38.2℃, cough, no sputum, sore throat, foreign body sensation in the throat, bad taste in the mouth, flushed face, acne, occasional headache, good appetite and sleep, dry stool, yellow urine, clinical symptom score of 10 points. After 5 doses of the Chinese medicine formula of the present invention, the patient's fever subsided, cough and sore throat were relieved, acne was reduced, and the clinical symptom score was 5 points.

[0070] Example 4

[0071] Xiao X, female, 26 years old. First diagnosis: fever with cough for 2 days. The patient had fever without obvious cause 2 days ago, T: 38.5℃, cough, cough with yellow sticky sputum, dry throat and sore throat, check for influenza A (+), blood routine LYM: 0.82×109 / L, CRP: 37mg / L, other tests were normal, and influenza A virus infection was considered. Now: fever, T: 38.2℃, cough, cough with yellow sticky sputum, dry throat and sore throat, no aversion to cold, not much sweating, flushed face, occasional headache, good appetite and sleep, dry stool, yellow urine, clinical symptom score 10 points. Five doses of the Chinese medicine formula of the present invention were given, and the patient occasionally had fever in the second diagnosis, T: 37.5℃, cough and sore throat were alleviated, and the clinical symptom score was 6 points.

[0072] Example 5

[0073] Long X, male, 32 years old. First diagnosis: Fever for 2 days. The patient had no obvious cause for fever 2 days ago, T: 38.8℃, with chills and fear of cold, not much sweating, and the fever was reduced after taking Ganmao Qingre Granules on his own, but cough, cough with yellow sputum, sore throat, and then check for influenza A (+), blood routine LYM: 0.66×109 / L, CRP: 56mg / L, other tests were normal, and influenza A virus infection was considered. Now: fever, T: 37.7℃, cough, cough with yellow sticky sputum, with dry throat and sore throat, no chills and fear of cold, irritable temperament, occasional panic, good appetite and sleep, dry stool, normal urine, clinical symptom score 9 points. Five doses of the Chinese medicine formula of the present invention were given, and the patient had no fever in the second diagnosis, T: 37.5℃, cough and sore throat were alleviated, and the clinical symptom score was 5 points.

[0074] Example 6

[0075] Wang X, female, 32 years old. First diagnosis: fever with cough for 3 days. The patient had fever without obvious cause 3 days ago, T: 37.9℃, with aversion to cold, not much sweating, sore throat, and the heat was reduced after taking cold and heat-clearing granules on his own, but the new cough, coughing yellow sputum, sore throat, Lianhua Qingwen granules, the symptoms did not reduce significantly, check A flu (+), blood routine showed no obvious abnormalities, and influenza A virus infection was considered. Now: fever, T: 37.5℃, cough and sore throat, hoarseness, not much sputum, dry mouth and bitter mouth, occasional panic, sleep, normal stool, yellow urine, clinical symptom score 8 points. Five doses of the Chinese medicine formula of the present invention were given, and the patient's fever subsided in the second diagnosis, and the cough and sore throat were significantly alleviated, with a clinical symptom score of 2 points.

[0076] The above is only an embodiment of the present invention, and the common knowledge such as the known specific technical solutions or characteristics in the solution is not described in detail here. It should be pointed out that for those skilled in the art, several modifications and improvements can be made without departing from the technical solution of the present invention, which should also be regarded as the protection scope of the present invention, and these will not affect the effect of the implementation of the present invention and the practicality of the patent. The scope of protection required by this application shall be based on the content of its claims, and the specific implementation methods and other records in the specification can be used to interpret the content of the claims.

Claims

1. A Chinese medicine formula for treating respiratory viral infection with cold-enclosed-fire syndrome, characterized in that: The Chinese medicine formula is composed of the following raw materials in the following weight proportions: 20-40 parts of gypsum, 10-20 parts of mint, 10-20 parts of cicada shells, 5-15 parts of raw liquorice, 10-20 parts of scutellaria, 5-15 parts of coptis, 10-20 parts of forsythia, 10-20 parts of honeysuckle, and 5-15 parts of platycodon.

2. A Chinese medicine formula for treating respiratory viral infection cold-enclosed-fire syndrome according to claim 1, characterized in that: The Chinese medicine formula is composed of the following raw materials in the following weight proportions: 30 parts of gypsum, 12 parts of mint, 15 parts of cicada shells, 10 parts of raw liquorice, 15 parts of scutellaria, 10 parts of coptis, 15 parts of forsythia, 15 parts of honeysuckle, and 10 parts of platycodon.

3. A method for preparing a traditional Chinese medicine formula for treating respiratory viral infection cold-enclosed-fire syndrome according to claim 1 or 2, characterized in that: The following steps are involved: S1. Preparation of API Selection and cleaning: First, select the APIs to remove impurities, non-medicinal parts, and damaged or deteriorated APIs; then clean the APIs to remove dust and dirt on the surface; Cutting and crushing: Cutting or crushing the API according to its characteristics and requirements; S2. Decoction Soaking: Put the API prepared in step S1 into a container and add clean water to soak for 30-60 minutes to allow the API to fully absorb water and swell; Decoction: Put the soaked raw materials and water into the decoction pot, heat until boiling, then turn to low heat and continue to decoct; and control the decoction time and heat according to the properties of the medicinal materials and the required efficacy; Combined decoction: Combine the medicinal liquids obtained from multiple decoctions to form a decoction; S3, Concentration Filtration: Filter the combined decoction to remove impurities and suspended matter; Concentration: Concentrate the filtered decoction and remove excess water by heating and evaporation; S4. Drying Use spray drying or vacuum drying to remove water from the drug solution while maintaining the active ingredients and efficacy of the drug solution; S5. Configuration and packaging According to the mass ratio of the raw materials, various Chinese medicine powders are mixed together to prepare an oral dosage form, and the mixture is packaged to obtain the required Chinese medicine formula.

4. The method for preparing a traditional Chinese medicine formula for treating respiratory viral infection cold-enclosed-fire syndrome according to claim 3, characterized in that: In step S5, the oral dosage form obtained is one of granules, oral liquid, powder, tablet, capsule, and pill.

5. The method for preparing a traditional Chinese medicine formula for treating respiratory viral infection cold-enclosed-fire syndrome according to claim 4, characterized in that: The prepared oral dosage form is granules and is packaged into bags.

6. Use of a traditional Chinese medicine formula for treating respiratory viral infection cold-enclosing-fire syndrome according to claim 1 or 2 in preparing treatment, prognosis or prognosis of respiratory viral infection cold-enclosing-fire syndrome with a tendency towards heat toxicity.