Anaesthesia machine capable of releasing hydrogen to reduce nerve injury

Abstract

The invention relates to the technical field of anaesthesia machines, in particular to an anaesthesia machine capable of releasing hydrogen to reduce nerve injury. The device comprises a movable base, a hydrogen generation device, a hydrogen flow rate sensing and control device, an anesthetic gas flow rate sensing and control device, an oxygen flow rate sensing and control device, a central gas flow rate sensing and control device, a physiological feature monitor, a gas monitoring display device, a breathing mask and a carbon dioxide recovery device. According to the anesthesia machine, hydrogen can be introduced while anesthetic gas is introduced, the hydrogen can relieve nerve injury caused by part of anesthetics, meanwhile, the anesthesia machine further has a gas concentration sensing function, the concentration of the anesthetic gas and the concentration of the hydrogen can be detected at any time in an operation, and operation proceeding and postoperative recovery of a patient are facilitated.

Description

Technical Field

[0001] The invention relates to the field of anesthesia machines, in particular to an anesthesia machine capable of releasing hydrogen to reduce nerve damage. Background Art

[0002] An anesthesia machine is an apparatus that delivers anesthetics into the patient's alveoli through a mechanical circuit to form an anesthetic gas partial pressure. After diffusing into the blood, it directly inhibits the central nervous system, thereby producing the effect of general anesthesia. Traditional anesthetics will continue to anesthetize the nervous system when used, causing some damage to the nervous system, which will cause damage to the patient in the long run. It is not conducive to the treatment. The anesthesia machines currently available on the market are mainly designed based on normal anesthesia effects, and there is no anesthesia machine with hydrogen treatment effects. In combination with existing patents, for example, CN116808386A is an anesthesia machine that can quickly replace the soda lime tank, which facilitates the daily maintenance of the anesthesia machine by medical staff, but there is not much improvement in terms of function. CN114392448A is an anesthesia machine that strengthens the precise control of the anesthesia process, which can improve the accuracy of medical staff's anesthesia operation, but there is not much improvement in the functionality of the anesthesia machine itself. The present invention provides a novel anesthesia machine, which can introduce hydrogen while introducing anesthetic gas. Hydrogen can reduce nerve damage caused by some anesthetics. At the same time, this anesthesia machine also has a gas concentration sensing function, which can detect the concentration of anesthetic gas and hydrogen at any time during surgery, which is beneficial to the progress of surgery and the postoperative recovery of patients. Summary of the invention

[0003] The invention provides an anesthesia machine capable of releasing hydrogen to reduce nerve damage.

[0004] The anesthesia machine of the present invention adopts the following technical solution:

[0005] An anesthesia machine that can release hydrogen to reduce nerve damage includes a mobile base and a hydrogen generator. The hydrogen generator has special wing-shaped plates on both sides, which are combined with the tracks on both sides of the mobile base and fixed with buckles. The upper part of the mobile base is a gas monitoring display device, and the upper part is an anesthetic gas storage tank and an oxygen storage tank. The left side of the gas monitoring display device is connected to a physiological characteristic monitor, and the right side of the gas monitoring display device is connected to a set of breathing masks, gas circulation pipelines and carbon dioxide recovery devices.

[0006] In some embodiments: the hydrogen generating device includes an electrolytic cell using an alkaline electrolyte with an inert electrode, and is equipped with a dedicated electrolysis control device. The hydrogen generating device can also be powered by an anesthesia machine power supply. One side of the hydrogen generating device is equipped with a pipeline for adding alkaline electrolyte, and in the case of insufficient alkaline electrolyte, alkaline electrolyte can be added without disassembling the machine.

[0007] In some embodiments: the hydrogen generating device is characterized in that: the hydrogen generating device is an independent module system, including an explosion-proof housing, an electrolytic cell, a gas monitoring device, a fire warning system, a gas drying device and a double-layer gas pipeline for gas transportation. The generated hydrogen is dried by the gas drying device and then mixed with the anesthetic gas through the double-layer gas pipeline for gas transportation. The hydrogen generating device can be independently disassembled and replaced for easy use.

[0008] In some embodiments: the physiological characteristic monitor is fixed to a mobile base by a support column, and above the support column is a circular base, on which the physiological characteristic monitor is placed. The base can drive the physiological characteristic monitor to rotate, and the physiological characteristic monitor has two electrode patches, which can monitor the brain's nervous system to a certain extent.

[0009] In some embodiments: the hydrogen flow rate sensing and control device can monitor the flow rate of hydrogen and calculate the total amount of hydrogen at this flow rate, and then transmit the calculation result to the gas monitoring and display device in real time. The gas monitoring and display device can automatically correct the hydrogen flow rate in automatic mode, and can also be manually modified by the operator in manual mode.

[0010] In some embodiments: the central gas flow rate sensing and control device can calculate the concentration according to the flow rate of the anesthetic gas, oxygen and hydrogen in the tube, and then provide negative feedback to the anesthetic gas flow rate sensing and control device, the oxygen flow rate sensing and control device and the hydrogen flow rate sensing and control device. After that, the anesthetic gas flow rate sensing and control device, the oxygen flow rate sensing and control device and the hydrogen flow rate sensing and control device will change the flow rate according to the feedback obtained.

[0011] In some embodiments: the gas exhalation part of the breathing mask is connected to the gas circulation pipeline and the one-way valve, and then connected to the bellows, and then connected to the carbon dioxide recovery device. The carbon dioxide recovery device will be connected to the front end of the central gas flow rate sensing control device, so that the central gas flow rate sensing control device can monitor the concentration of the gas discharged by the carbon dioxide recovery device, and adjust it in time to ensure the normal circulation of the breathing circuit.

[0012] The present invention has at least the following beneficial effects:

[0013] When using the anesthesia machine shown in the present invention, the gas flow rate and control device of each part can effectively control the gas flow rate and air intake volume, which helps the anesthesiologist to monitor the patient's physiological condition in real time and change the required concentration on the gas monitoring display device at any time to prevent the patient from having physiological problems due to different gas component ratios.

[0014] When the anesthesia machine shown in the present invention is used, the hydrogen generated by the hydrogen generating device can alleviate nerve damage caused by inhalation of anesthetic gas, reduce anesthesia sequelae, and help patients recover after surgery.

[0015] When the anesthesia machine shown in the present invention is used, the machine body is equipped with a hydrogen generator, and no additional hydrogen generator is required. In addition, the hydrogen generator has explosion-proof measures, which can increase safety while reducing redundant equipment.

[0016] When the anesthesia machine of the present invention is used, a hydrogen leakage protection device is attached around the hydrogen generating device. The device can monitor the concentration of hydrogen and timely process the remaining hydrogen at the end of the operation to prevent danger.

[0017] When using the anesthesia machine of the present invention, if the hydrogen generator has a problem and needs to be replaced, the device itself can be replaced alone, without replacing the entire anesthesia machine, thereby reducing cost consumption. Moreover, the hydrogen generator is relatively independent from the anesthesia machine body, and even without the hydrogen generator, the anesthesia machine body can still work normally, and only the pipelines related to hydrogen generation need to be closed. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 This is a front structural schematic diagram of the anesthesia machine of the present invention. Figure 2 Schematic diagram of the hydrogen generating device of the anesthesia machine shown in the present invention Figure 3 Schematic diagram of the gas circuit shown in the present invention Description of Reference Numerals 1. Physiological characteristic monitor; 101. Electrode patch; 15. Central gas flow rate sensing and control device; 2. Gas monitoring and display device; 201. Anesthetic gas storage tank; 202. Oxygen storage tank; 203. Gas circulation pipeline; 204. Breathing mask; 21. Carbon dioxide recovery device; 3. Anesthetic gas flow rate sensing and control device; 4. Oxygen flow rate sensing and control device; 5. Hydrogen flow rate sensing and control device; 6. Mobile base; 61. Wing plate; 8. Hydrogen generation device; 81. Explosion-proof housing; 82. Gas monitoring device; 83. Fire warning system; 84. Gas drying device; 85. Double-layer gas pipeline; 86. Inert electrode; 87. Electrolytic cell; 88. Special electrolysis control device; 89. Pipeline for adding alkaline electrolyte DETAILED DESCRIPTION

[0019] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0020] Please refer to the legend, the present invention provides a technical solution:

[0021] Please refer to Figure 1 , Figure 1 A front view of an anesthesia machine that can release hydrogen to reduce nerve damage provided in an embodiment of the present application. It includes a mobile base 6 and a hydrogen generating device 8; wherein, the hydrogen generating device 8 has special wing-shaped plates 61 on both sides for connecting with the mobile base 6. The upper part of the mobile base 6 is a gas monitoring display device 2, the left side of the gas monitoring display device 2 is connected to the physiological characteristic monitor 1, and the right side of the gas monitoring display device 2 is connected to a set of breathing masks 204 and a carbon dioxide recovery device 21;

[0022] On the left side of the anesthesia machine is the physiological characteristic monitor 1. Before the patient begins anesthesia, the physiological characteristic monitor 1 is turned on and the electrode patch 101 is attached to the patient's forehead to monitor the patient's brain electrical signals. After the power is connected, the gas monitoring display device 2 is operated to control the display. The gas storage tank 201 and the oxygen storage tank 202, as well as the operation of the hydrogen generator 8, will be displayed on the gas monitoring display device 2. Then, the electrolytic cell start switch located in the gas monitoring display device 2 is turned on, and the electrolytic cell 87 starts working to generate hydrogen by electrolyzing water. The alkaline electrolyte in the electrolytic cell 87 itself does not participate in the reaction, and is added to promote the process of electrolyzing water and speed up the reaction.

[0023] When anesthesia begins, the gas monitoring and display device 2 can detect all gas flow conditions in real time; for example, when the hydrogen content inside the gas circulation is too high, the gas monitoring and display device 2 will provide feedback to the dedicated electrolysis control device 88, and the dedicated electrolysis control device 88 will reduce the voltage to slow down the speed of electrolyzing water, thereby controlling the release of hydrogen.

[0024] Please refer to Figure 2 , Figure 2The hydrogen generating device 8 of the anesthesia machine that can release hydrogen to reduce nerve damage provided in the embodiment of the present application. The hydrogen generating device 8 comprises an explosion-proof housing 81, an electrolytic cell 87, a gas monitoring device 82, a fire warning device 83, and a gas drying device 84. When the anesthesia machine starts to operate, the gas monitoring and display device 2 can send a signal to start the dedicated electrolysis control device 88. At this time, the electrolytic cell 87 starts to perform an electrolysis reaction to produce hydrogen and oxygen. The produced hydrogen and oxygen enter the working system of the anesthesia machine through the double-layer gas pipeline 85, mix with the anesthetic gas and oxygen, and are introduced into the patient's body together.

[0025] Please refer to Figure 3 , Figure 3 The embodiment of the present application provides a circulation loop for each gas of an anesthesia machine that can release hydrogen to reduce nerve damage. After the anesthesia machine system starts working, the anesthetic gas flow rate sensing and control device 3, the oxygen flow rate sensing and control device 4, the hydrogen flow rate sensing and control device 5 and the central gas flow rate sensing and control device 15 will start working at the same time and monitor the gases they are responsible for. Various data will be displayed on the gas monitoring display device 2 for the user to monitor and adjust at any time. In automatic mode, the anesthetic gas flow rate sensing and control device 3, the oxygen flow rate sensing and control device 4, the hydrogen flow rate sensing and control device 5 and the central gas flow rate sensing and control device 15 will automatically adjust according to the set value. In manual mode, the operator can manually adjust the value.

[0026] Please refer to Figure 1 Third, after the mixed anesthetic gas enters the gas circulation pipeline 203, it will enter the patient's body through the breathing mask 204. The carbon dioxide and other gases exhaled by the patient will be recovered through the carbon dioxide recovery device 21 to complete the circulation of the gas passage.

[0027] Example 1

[0028] An anesthesia machine capable of releasing hydrogen, a mobile base 6 and a hydrogen generating device 8. The hydrogen generating device 8 comprises an explosion-proof housing 81, an electrolytic cell 87, a gas monitoring device 82, a fire warning device 83, and a gas drying device 84. Special wing-shaped plates 61 are provided on both sides of the hydrogen generating device 8 for connecting with the mobile base 6. The left side of the anesthesia machine is a physiological characteristic monitor 1. Before the patient starts anesthesia, the physiological characteristic monitor 1 is turned on and the electrode patch 101 is attached to the patient's forehead to monitor the patient's brain electrical signals; after the power supply is connected, the display where the gas monitoring display device 2 is located is manipulated for control; the gas monitoring display device 2 will display the gas storage of the anesthesia gas storage tank 201 and the oxygen storage tank 202, as well as the operation of the hydrogen generating device 8. After that, the electrolytic cell start switch located at the gas monitoring display device 2 is turned on, and the electrolytic cell 87 starts to work and generates hydrogen by electrolyzing water.

[0029] When anesthesia begins, the operator will adjust the required hydrogen concentration to 1% of the total mass of the anesthetic gas through the gas monitoring and display device 2. The gas monitoring and display device 2 can detect all gas flow conditions in real time; for example, when the hydrogen content inside the gas circulation is too high, the gas monitoring and display device 2 will provide feedback to the dedicated electrolysis control device 88, and the dedicated electrolysis control device 88 will reduce the voltage to slow down the speed of electrolyzing water, thereby controlling the release of hydrogen.

[0030] When the anesthesia machine starts to operate, the operator sends a signal through the gas monitoring display device 2 to start the special electrolysis control device 88. At this time, the electrolytic cell 87 starts to perform an electrolysis reaction to produce hydrogen and oxygen. The produced hydrogen and oxygen enter the anesthesia machine working system through the double-layer gas pipeline 85. After the mixed anesthetic gas enters the gas circulation pipeline 203, it will enter the patient's body through the breathing mask 204. The carbon dioxide and other gases exhaled by the patient will be recovered through the carbon dioxide recovery device 21 to complete the circulation of the gas path.

[0031] Example 2

[0032] It is basically the same as Example 1, except that when anesthesia begins, the operator will adjust the required hydrogen concentration to 2% of the total mass of the anesthetic gas through the gas monitoring and display device 2.

[0033] Example 3

[0034] It is basically the same as Example 1, except that when anesthesia begins, the operator will adjust the required hydrogen concentration to 4% of the total mass of the anesthetic gas through the gas monitoring and display device 2.

[0035] Comparative Example 1

[0036] It is basically the same as Example 1, except that when anesthesia begins, the operator will adjust the required hydrogen concentration to 0% of the total mass of the anesthetic gas through the gas monitoring and display device 2, and deactivate the hydrogen generating device 8, so that there is no hydrogen in the mixed gas inhaled by the patient.

[0037] Test Method

[0038] For animal experiments, healthy adult mice were selected as experimental subjects to ensure that all animals were in good physiological condition before the experiment.

[0039] Anesthesia machine settings: Using the anesthesia machine of the present invention, hydrogen gas at different concentrations was mixed with 21% oxygen for inhalation and delivered to mice through the breathing circuit of the anesthesia machine.

[0040] Experimental grouping: The mice were randomly divided into four groups, with a certain number of mice in each group. The amount of hydrogen inhaled by each group was adjusted according to the settings of Examples 1-3 and Comparative Example 1.

[0041] Experimental process: All mice were subjected to laparotomy under anesthesia. During the operation, they were respectively exposed to hydrogen gas of the concentrations of Examples 1-3 and Comparative Example 1 mixed with 21% oxygen. Until the end of the operation (record the time). The vital signs of the mice during anesthesia, including respiratory rate, heart rate, body temperature, etc., were observed and recorded.

[0042] Postoperative neurological evaluation: 30 days after surgery, behavioral tests (including water maze test, cross test and novel object recognition test) were performed: histological examination (including the number of hippocampal tissue apoptosis, the number of neuronal necrosis, and the examination of blood-brain barrier permeability). The test results are shown in Table 1.

[0043] Test results: Table 1

[0044] Experimental Results

[0045] Depend on Figure 1 Behavioral test: 30 days after surgery, the mice showed certain behavioral disorders, such as uncoordinated movement and slow reaction.

[0046] However, compared with the control group 1, the mice in the examples 1-3 groups recovered faster after anesthesia, had better behavioral coordination, and significantly improved cognitive function.

[0047] Histological examination: Through section staining observation, it was found that compared with the mice in comparative example 1, the neuron morphology of the mice in examples 1-3 was more normal and the number was not reduced.

[0048] The experimental results show that when the anesthesia machine of the present invention is used to deliver mixed gas to animals under anesthesia, the amount of hydrogen inhaled has a significant effect on the animal's nervous system. A certain concentration of hydrogen can reduce neuronal apoptosis and improve nerve function.

Claims

1. An anesthesia machine capable of releasing hydrogen to reduce nerve damage, comprising a mobile base (6) and a hydrogen generating device (8); wherein: The hydrogen generating device (8) has special wing-shaped plates (61) on both sides for connecting to the mobile base (6); the upper part of the mobile base (6) is a gas monitoring display device (2), the left side of the gas monitoring display device (2) is connected to the physiological characteristic monitor (1), and the upper part is an anesthetic gas storage tank (201) and an oxygen storage tank (202); the right side of the gas monitoring display device (2) is connected to a set of breathing masks (204), a gas circulation pipeline (203) and a carbon dioxide recovery device (21).

2. The anesthesia machine capable of releasing hydrogen to reduce nerve damage according to claim 1, characterized in that: The hydrogen generating device (8) comprises an electrolytic cell (87) using an alkaline electrolyte and using an inert electrode (86), and is equipped with a dedicated electrolysis control device (88); the hydrogen generating device (8) can also be powered by an anesthesia machine power supply; one side of the hydrogen generating device (8) is equipped with a pipe (89) for adding alkaline electrolyte, and when the alkaline electrolyte is insufficient, the alkaline electrolyte can be added without disassembling the machine.

3. The anesthesia machine capable of releasing hydrogen to reduce nerve damage according to claim 2, characterized in that: The hydrogen generating device (8) is an independent module system, comprising an explosion-proof housing (81), an electrolytic cell (87), a gas monitoring device (82), a fire warning system (83), a gas drying device (84) and a double-layer gas pipeline (85) for gas transportation; the generated hydrogen is dried by the gas drying device (84) and then mixed with the anesthetic gas through the double-layer gas pipeline (85) for gas transportation; the hydrogen generating device (8) can be independently disassembled and replaced, and is convenient to use.

4. The anesthesia machine capable of releasing hydrogen to reduce nerve damage according to claim 1, characterized in that: The anesthesia machine comprises a physiological characteristic monitor (1); the physiological characteristic monitor (1) is fixed on a movable base (6) by a support column, and a circular base is disposed above the support column, on which the physiological characteristic monitor (1) is placed, and the base can drive the physiological characteristic monitor (1) to rotate, and the physiological characteristic monitor (1) is provided with two electrode patches (101), which can monitor the brain nervous system to a certain extent.

5. The anesthesia machine capable of releasing hydrogen to reduce nerve damage according to claim 2, characterized in that: The hydrogen generating device (8) comprises a hydrogen flow rate sensing and control device (5); the hydrogen flow rate sensing and control device (5) can monitor the flow rate of hydrogen and calculate the total amount of hydrogen at this flow rate, and then transmit the calculation result to the gas monitoring and display device (2) in real time. The gas monitoring and display device (2) can automatically correct the hydrogen flow rate in automatic mode, and can also be manually modified by an operator in manual mode.

6. The anesthesia machine capable of releasing hydrogen to reduce nerve damage according to claim 1, characterized in that: The anesthesia machine comprises a group of flow rate sensing and control devices; the group of flow rate sensing and control devices comprises a central gas flow rate sensing and control device (15), an anesthetic gas flow rate sensing and control device (3), an oxygen flow rate sensing and control device (4) and a hydrogen flow rate sensing and control device (5); the central gas flow rate sensing and control device (15) can calculate the concentration according to the flow rates of the anesthetic gas, oxygen and hydrogen in the tube, and then provide negative feedback to the anesthetic gas flow rate sensing and control device (3), the oxygen flow rate sensing and control device (4) and the hydrogen flow rate sensing and control device (5), and then the anesthetic gas flow rate sensing and control device (3), the oxygen flow rate sensing and control device (4) and the hydrogen flow rate sensing and control device (5) will change the flow rate according to the feedback obtained.

7. The anesthesia machine capable of releasing hydrogen to reduce nerve damage according to claim 1, characterized in that: The anesthesia machine comprises a set of breathing masks (204) and a carbon dioxide recovery device (21); the gas exhalation portion of the breathing mask (204) is connected to a gas circulation pipeline (203) and a one-way valve, then connected to a bellows, and then connected to a carbon dioxide recovery device (21); the carbon dioxide recovery device (21) is connected to the front end of a central gas flow rate sensing control device (15), so that the central gas flow rate sensing control device (15) can monitor the concentration of the gas discharged by the carbon dioxide recovery device and make timely adjustments to ensure the normal circulation of the breathing circuit.

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