A traditional Chinese medicine composition for palpitations and its preparation method

Abstract

This invention belongs to the field of medicine, specifically relating to a traditional Chinese medicine composition for palpitations and its preparation method. Each dose of the traditional Chinese medicine composition of this invention comprises the following components by weight: Atractylodes macrocephala 5-20g, Astragalus membranaceus 5-15g, fresh ginger 5-15g, Codonopsis pilosula 5-20g, Ophiopogon japonicus 5-15g, Cinnamomum cassia twig 5-15g, Rehmannia glutinosa 15-25g, prepared licorice root 5-20g, jujube 5-20g, vinegar-processed Schisandra chinensis 3-7g, Platycladus orientalis seed 5-15g, charred hawthorn 5-15g, Magnolia officinalis 5-15g, Alpinia oxyphylla seed 5-15g, Amomum villosum 10-20g, and roasted malt 10-20g. The above components, through organic combination, work together to replenish qi and blood, stabilize the mind, comprehensively regulate the body's immunity, and have the effects of nourishing yin and blood, invigorating qi and warming yang, restoring pulse and calming palpitations. It is mainly used to treat palpitations caused by insufficient yin and blood and deficiency of qi and yin, with significant therapeutic effects.

Description

Technical Field

[0001] This invention belongs to the field of medicine, specifically relating to a traditional Chinese medicine composition for palpitations and its preparation method. Background Technology

[0002] Palpitation is a subjective feeling of discomfort or anxiety related to the heartbeat. It is felt when the heart rate is fast and when it is slow. During palpitation, the heart rate can be fast or slow, and arrhythmias may occur; palpitations can also occur in people with normal heart rate and rhythm. Because palpitations have many causes, they are clinically often triggered by emotional fluctuations or fatigue. Therefore, in daily life, the cautious use of over-the-counter medications for appropriate conditioning, improving physical fitness, and enhancing the body's immunity have significant effects on the prevention and treatment of palpitations. Thus, providing a suitable daily conditioning medication for patients with palpitations has positive clinical significance. Summary of the Invention

[0003] This invention provides a traditional Chinese medicine composition for palpitations and its preparation method, which can effectively prevent and treat palpitations and can be used for daily conditioning by palpitation patients.

[0004] The technical solution of this invention is implemented as follows:

[0005] A traditional Chinese medicine composition for palpitations, each dose comprising the following components by weight: Atractylodes macrocephala 5-20g, Astragalus membranaceus 5-15g, fresh ginger 5-15g, Codonopsis pilosula 5-20g, Ophiopogon japonicus 5-15g, Cinnamomum cassia 5-15g, Rehmannia glutinosa 15-25g, prepared licorice root 5-20g, jujube 5-20g, vinegar-processed Schisandra chinensis 3-7g, Platycladus orientalis seed 5-15g, charred hawthorn 5-15g, Magnolia officinalis 5-15g, Alpinia oxyphylla 5-15g, Amomum villosum 10-20g, and roasted malt 10-20g.

[0006] Furthermore, the traditional Chinese medicine composition for palpitations comprises the following ingredients in g weight: Atractylodes macrocephala 10g, Astragalus membranaceus 10g, fresh ginger 10g, Codonopsis pilosula 10g, Ophiopogon japonicus 10g, Cinnamomum cassia 10g, Rehmannia glutinosa 20g, prepared licorice root 10g, jujube 10g, vinegar-processed Schisandra chinensis 5g, Platycladus orientalis seed 10g, charred hawthorn 10g, Magnolia officinalis 10g, Alpinia oxyphylla 10g, Amomum villosum 15g, and roasted malt 15g.

[0007] A method for preparing a traditional Chinese medicine composition for palpitations includes the following steps:

[0008] Take the prescribed amounts of Atractylodes macrocephala, Astragalus membranaceus, fresh ginger, Codonopsis pilosula, Ophiopogon japonicus, Cinnamomum cassia, Rehmannia glutinosa, prepared licorice root, jujube, vinegar-processed Schisandra chinensis, Platycladus orientalis seed, charred hawthorn, Magnolia officinalis, Alpinia oxyphylla, Amomum villosum, and roasted malt. Add water and decoct. Take the filtrate.

[0009] Furthermore, the amount of water added should be 3-5 centimeters above the medicinal materials.

[0010] Furthermore, the simmering time is 30-40 minutes, and it is simmered 2-3 times.

[0011] The above-described traditional Chinese medicine composition is used in the preparation of formulations for treating palpitations.

[0012] The above-described traditional Chinese medicine composition is used in the preparation of formulations that enhance the ability to resist fatigue.

[0013] Furthermore, in the aforementioned application, the traditional Chinese medicine composition is taken once a day, divided into two doses, each dose being 1 / 2 of a dose.

[0014] A preparation for treating palpitations, comprising the above-mentioned traditional Chinese medicine composition.

[0015] The beneficial effects of this invention are:

[0016] The traditional Chinese medicine composition of this invention comprises organically combined ingredients. The principal ingredient is Rehmannia glutinosa, which nourishes Yin and blood. According to the *Mingyi Bielu*, Rehmannia glutinosa "replenishes deficiencies in the five internal organs, unblocks blood vessels, and strengthens Qi." It is combined with prepared licorice root, Codonopsis pilosula, jujube, Atractylodes macrocephala, and Astragalus membranaceus to benefit heart Qi and replenish spleen Qi, thus providing the source of Qi and blood production. Ophiopogon japonicus and Schisandra chinensis nourish heart Yin, replenish heart blood, and fill blood vessels, serving as assistant ingredients. Cinnamomum cassia and ginger are used as adjuvant ingredients to warm and invigorate, warming heart Yang and unblocking blood vessels. Platycladus orientalis seed nourishes the heart, calms the mind, and relieves palpitations. Roasted hawthorn, Magnolia officinalis, Amomum villosum, and roasted malt promote Qi circulation, unblock blood vessels, harmonize the stomach, and aid digestion. These rich and nourishing ingredients are not cloying. Alpinia oxyphylla warms the spleen and kidneys, warming and unblocking the blood vessels of the spleen and kidneys to enhance the medicinal power of Qi and blood production, while also harmonizing the heart and kidneys, serving as the guiding ingredient. The above-mentioned components, through organic combination, work together to replenish qi and blood, stabilize the mind, and comprehensively regulate the body's immunity. They have the effects of nourishing yin and blood, invigorating qi and warming yang, restoring pulse and calming palpitations. They are mainly used to treat palpitations caused by insufficient yin and blood and deficiency of qi and yin, with significant therapeutic effects. Detailed Implementation

[0017] The technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0018] Example 1

[0019] A traditional Chinese medicine composition for palpitations, each dose comprising the following components by weight (g): Atractylodes macrocephala 10g, Astragalus membranaceus 10g, fresh ginger 10g, Codonopsis pilosula 10g, Ophiopogon japonicus 10g, Cinnamomum cassia 10g, Rehmannia glutinosa 20g, prepared licorice root 10g, jujube 10g, vinegar-processed Schisandra chinensis 5g, Platycladus orientalis seed 10g, charred hawthorn 10g, Magnolia officinalis 10g, Alpinia oxyphylla 10g, Amomum villosum 15g, and roasted malt 15g.

[0020] A method for preparing a traditional Chinese medicine composition for palpitations includes the following steps:

[0021] Take the prescribed amounts of Atractylodes macrocephala, Astragalus membranaceus, fresh ginger, Codonopsis pilosula, Ophiopogon japonicus, Cinnamomum cassia, Rehmannia glutinosa, prepared licorice root, jujube, Schisandra chinensis (vinegar-processed), Platycladus orientalis seed, charred hawthorn, Magnolia officinalis, Alpinia oxyphylla, Amomum villosum, and roasted malt. Add water to cover the herbs by 3-5 cm and decoct for 30-40 minutes. Repeat the decoction 2-3 times and collect the filtrate.

[0022] Example 2

[0023] A traditional Chinese medicine composition for palpitations, each dose comprising the following components by weight: Atractylodes macrocephala 5g, Astragalus membranaceus 5g, fresh ginger 5g, Codonopsis pilosula 5g, Ophiopogon japonicus 5g, Cinnamomum cassia 5g, Rehmannia glutinosa 15g, prepared licorice root 5g, jujube 5g, vinegar-processed Schisandra chinensis 3g, Platycladus orientalis seed 5g, charred hawthorn 5g, Magnolia officinalis 5g, Alpinia oxyphylla 5g, Amomum villosum 10g, and roasted malt 10g.

[0024] A method for preparing a traditional Chinese medicine composition for palpitations includes the following steps:

[0025] Take the prescribed amounts of Atractylodes macrocephala, Astragalus membranaceus, fresh ginger, Codonopsis pilosula, Ophiopogon japonicus, Cinnamomum cassia, Rehmannia glutinosa, prepared licorice root, jujube, Schisandra chinensis (vinegar-processed), Platycladus orientalis seed, charred hawthorn, Magnolia officinalis, Alpinia oxyphylla, Amomum villosum, and roasted malt. Add water to cover the herbs by 3-5 cm and decoct for 30-40 minutes. Repeat the decoction 2-3 times and collect the filtrate.

[0026] Example 3

[0027] A traditional Chinese medicine composition for palpitations, each dose comprising the following components by weight: Atractylodes macrocephala 20g, Astragalus membranaceus 15g, fresh ginger 15g, Codonopsis pilosula 20g, Ophiopogon japonicus 15g, Cinnamomum cassia 15g, Rehmannia glutinosa 25g, prepared licorice root 20g, jujube 20g, vinegar-processed Schisandra chinensis 7g, Platycladus orientalis seed 15g, charred hawthorn 15g, Magnolia officinalis 15g, Alpinia oxyphylla 15g, Amomum villosum 20g, and roasted malt 20g.

[0028] A method for preparing a traditional Chinese medicine composition for palpitations includes the following steps:

[0029] Take the prescribed amounts of Atractylodes macrocephala, Astragalus membranaceus, fresh ginger, Codonopsis pilosula, Ophiopogon japonicus, Cinnamomum cassia, Rehmannia glutinosa, prepared licorice root, jujube, Schisandra chinensis (vinegar-processed), Platycladus orientalis seed, charred hawthorn, Magnolia officinalis, Alpinia oxyphylla, Amomum villosum, and roasted malt. Add water to cover the herbs by 3-5 cm and decoct for 30-40 minutes. Repeat the decoction 2-3 times and collect the filtrate.

[0030] (I) In vitro efficacy study

[0031] Since fatigue is a significant factor leading to palpitations, improving fatigue resistance can effectively prevent palpitations. Exercise endurance directly reflects fatigue resistance. This invention uses a mouse swimming experiment to examine the differences in fatigue resistance among different formulations and to evaluate the differences in efficacy among different formulations.

[0032] SPF-grade Kunming mice, weighing 20-22g, were randomly divided into groups of six (half male and half female) for the experiment. The mice were administered the drug via gavage at a dose of 10ml / kg, three times daily. The experiment consisted of an experimental group, a control group, and a blank control group. The experimental groups were given the traditional Chinese medicine compositions prepared in the three examples. The control group prepared the drug solution according to the method in Example 1, using the following combination of medicinal materials. The blank control group received an equal volume of physiological saline. All mice were uniformly housed and allowed free access to food.

[0033] Comparative Example 1: Atractylodes macrocephala 10g, Astragalus membranaceus 10g, fresh ginger 10g, Codonopsis pilosula 10g, Ophiopogon japonicus 10g, Cinnamomum cassia 10g, Rehmannia glutinosa 20g, prepared licorice root 10g, jujube 10g, vinegar-processed Schisandra chinensis 5g, Platycladus orientalis seed 10g, Magnolia officinalis 10g.

[0034] Comparative Example 2: Atractylodes macrocephala 10g, Astragalus membranaceus 10g, fresh ginger 10g, Codonopsis pilosula 10g, Ophiopogon japonicus 10g, Cinnamomum cassia 10g, Rehmannia glutinosa 20g, prepared licorice root 10g, jujube 10g, vinegar-processed Schisandra chinensis 5g, Platycladus orientalis seed 10g, Magnolia officinalis 10g, Amomum villosum 15g, stir-fried malt 15g.

[0035] Comparative Example 3: Atractylodes macrocephala 10g, Astragalus membranaceus 10g, fresh ginger 10g, Codonopsis pilosula 10g, Ophiopogon japonicus 10g, Cinnamomum cassia 10g, Rehmannia glutinosa 20g, prepared licorice root 10g, jujube 10g, vinegar-processed Schisandra chinensis 5g, Platycladus orientalis seed 10g, Magnolia officinalis 10g, charred hawthorn 10g, Alpinia oxyphylla 10g.

[0036] Ten days after gavage, all mice underwent a swimming experiment 30 minutes after the last gavage. Mice were weighed, and lead sheets were attached to the base of their tails at 5% of their body weight. The swimming tank was set at 25°C and 40cm in depth. Mice were placed in the tank and the time from the start of swimming to death was recorded. The results are shown in Table 1.

[0037] Table 1. Effects of different formulations on swimming time in mice.

[0038] processing method Swimming time (min) Example 1 140.1 Example 2 137.2 Example 3 139.5 Comparative Example 1 110.6 Comparative Example 2 123.3 Comparative Example 3 112.8 Blank group 105.3

[0039] As shown in Table 1, compared with the blank group, the swimming time of mice in both the example group and the comparative group was increased to varying degrees, indicating that the traditional Chinese medicine composition administered by gavage to both the example group and the comparative group can improve the fatigue resistance of mice. The swimming time of mice in the example group was significantly improved compared with the comparative group, indicating that the traditional Chinese medicine composition described in this invention can significantly improve the fatigue resistance of experimental mice, effectively prevent palpitations, and demonstrate a significant improvement in efficacy.

[0040] (II) Clinical efficacy evaluation

[0041] Using the "Guiding Principles for Clinical Research of New Traditional Chinese Medicine (Trial Implementation)" as the diagnostic criteria, this study included 120 patients with palpitations who visited the First Affiliated Hospital of Hainan Medical University. They were randomly divided into three groups: an experimental group (treating patients with traditional Chinese medicine) and a control group (treating patients with Western medicine), with 30 patients in each group. There were no statistically significant differences between the two groups in terms of gender, age, and disease duration (P>0.05), indicating comparability. This study was approved by the Ethics Committee of Hainan Medical University, and informed consent was obtained from all patients and their families.

[0042] The example group was treated with the traditional Chinese medicine compositions prepared in Examples 1-3, one dose daily, taken orally as a decoction, half a dose each time. One course of treatment lasted 7 days, with a maximum of 5 courses. Treatment effects were statistically analyzed. The control group received symptomatic treatment with appropriate Western medicine. Smoking and alcohol consumption were prohibited during treatment. A follow-up visit was conducted one month after treatment completion to assess recurrence.

[0043] Table 2 Clinical efficacy study of the traditional Chinese medicine composition described in this invention

[0044]

[0045] As shown in Table 2, the overall effective rate of this invention can reach over 90%, and the cure rate can reach over 43%, both significantly higher than the control group. In the one-month follow-up, the recurrence rate was significantly lower in the three embodiments compared to the control group (6 recurrences per person), with 3, 2, and 2 recurrences respectively. Therefore, compared to the control group, the overall effective rate and cure rate of the three embodiments of this invention are significantly improved, and the recurrence rate is significantly reduced, indicating that the traditional Chinese medicine composition described in this invention has a significant therapeutic effect on palpitations.

[0046] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A traditional Chinese medicine composition for palpitations, characterized in that, Each dose is made from the following components by weight: Atractylodes macrocephala 5-20g, Astragalus membranaceus 5-15g, fresh ginger 5-15g, Codonopsis pilosula 5-20g, Ophiopogon japonicus 5-15g, Cinnamomum cassia 5-15g, Rehmannia glutinosa 15-25g, prepared licorice root 5-20g, jujube 5-20g, vinegar-processed Schisandra chinensis 3-7g, Platycladus orientalis seed 5-15g, charred hawthorn 5-15g, Magnolia officinalis 5-15g, Alpinia oxyphylla 5-15g, Amomum villosum 10-20g, and roasted malt 10-20g.

2. The traditional Chinese medicine composition for palpitations as described in claim 1, characterized in that, Each dose is made from the following ingredients by weight: Atractylodes macrocephala 10g, Astragalus membranaceus 10g, fresh ginger 10g, Codonopsis pilosula 10g, Ophiopogon japonicus 10g, Cinnamomum cassia 10g, Rehmannia glutinosa 20g, prepared licorice root 10g, jujube 10g, vinegar-processed Schisandra chinensis 5g, Platycladus orientalis seed 10g, charred hawthorn 10g, Magnolia officinalis 10g, Alpinia oxyphylla 10g, Amomum villosum 15g, and roasted malt 15g.

3. A method for preparing a traditional Chinese medicine composition for palpitations as described in claim 1 or 2, characterized in that, Includes the following steps: Take the prescribed amounts of Atractylodes macrocephala, Astragalus membranaceus, fresh ginger, Codonopsis pilosula, Ophiopogon japonicus, Cinnamomum cassia, Rehmannia glutinosa, prepared licorice root, jujube, vinegar-processed Schisandra chinensis, Platycladus orientalis seed, charred hawthorn, Magnolia officinalis, Alpinia oxyphylla, Amomum villosum, and roasted malt. Add water and decoct. Take the filtrate.

4. The preparation method according to claim 3, characterized in that, Add water to cover the herbs by 3-5 centimeters.

5. The preparation method according to claim 3, characterized in that, The simmering time is 30-40 minutes, and it is simmered 2-3 times.

6. The use of the traditional Chinese medicine composition for palpitations as described in claim 1 or 2 in the preparation of a formulation for treating palpitations.

7. The use of the traditional Chinese medicine composition for palpitations as described in claim 1 or 2 in the preparation of formulations that enhance anti-fatigue ability.

8. The application as described in claim 6 or 7, characterized in that, The aforementioned traditional Chinese medicine composition is taken once a day, divided into two doses, each dose being 1 / 2 of a dose.

9. A preparation for treating palpitations, characterized in that, Includes the traditional Chinese medicine composition as described in claim 1 or 2.

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