Costus oil liniment for treating myasthenia and preparation method and application thereof

Abstract

The invention relates to the technical field of traditional Chinese medicine and ethnic medicine, in particular to costus oil liniment for treating myasthenia and a preparation method and application of the costus oil liniment for treating myasthenia, the costus oil liniment for treating myasthenia is prepared from costus root, beaver herb, black pepper, euphorbia pekinensis fat, pyrethrum root and olive oil, and the invention provides a preparation process of the liniment. Animal experiments and clinical tests show that the costus oil liniment for treating myasthenia can effectively improve the excitation-contraction coupling function of neuromuscular joints, increase muscle strength and improve the body movement function, and has good popularization and application value; and a new way is provided for treatment of myasthenia. The costus oil liniment for treating myasthenia is safe and convenient to use, multiple in disease types, wide in application range, quick in effect, definite in curative effect, free of side effects, simple in preparation process, low in cost, rich in medicinal material source and worthy of popularization and application.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicine and ethnic medicine, and is a costusroot oil liniment for treating myasthenia, and a preparation method and application thereof. Background Art

[0002] Myasthenia is the earliest and most common disuse syndrome. Disuse syndrome is a secondary complication caused by various reasons such as aging of the body, primary disease or treatment measures, such as patients being forced to stay in bed for a long time, immobilization caused by reduced or insufficient activity, sensory disturbances caused by reduced stimulation, and weightlessness at high altitude. In a state of disuse, the movement and sensation of the limbs that are completely inactive, as well as motor nerve dysfunction, muscle strength gradually decreases, and the muscle's ability to resist fatigue decreases. If treatment is not started early, myasthenia is very likely to occur. Studies have shown that the isometric muscle strength of a limb that is completely inactive can decrease by 1% to 3% per day, 10% to 20% per week, and 50% in 3 to 5 weeks. As the disuse time increases, the patient's daily living ability and quality of life are declining, and the impact on physical health, medical costs, and care burden has attracted widespread attention from the society.

[0003] The medication treatment of myasthenia further enhances the rehabilitation of the motor system. So far, there is no literature reporting targeted and effective drugs for myasthenia syndrome. Traditional Chinese medicine (Uyghur medicine) has certain theoretical achievements and unique methods in the treatment of diseases. Humoral pathology (humor theory) is the core of the basic theory of traditional Chinese medicine (Uyghur medicine). According to the theory of humors, disuse myasthenia is mainly caused by the excessively thin mucus filling the muscles and tendons caused by the tasteless mucus in the abnormal mucus syndrome, which relaxes the tendons and muscles and affects the muscle function and morphological structure.

[0004] According to the compatibility method of traditional Chinese medicine (Uyghur medicine), the wood fragrance oil liniment is made, which has special effects in the treatment and prevention of myasthenia, and has the functions of promoting blood circulation and removing blood stasis, improving local blood circulation, clearing abnormal mucus at the neuromuscular junction, opening blockage, removing cold and dampness, generating heat, warming up and strengthening yang, strengthening tendons and muscles, nourishing nerves, and nourishing the brain. It mainly treats damp-cold or mucous diseases, such as myasthenia, weakness of tendons and muscles, muscle relaxation, flaccidity, facial paralysis, paralysis, cramps, tremors, hysteria, dementia and heavy tongue, backache and impotence, loss of libido, loose semen, neurasthenia, sciatica, joint pain, rheumatic pain, etc. Therefore, the development of wood fragrance oil liniment with the function of treating myasthenia from Chinese medicine (Uyghur medicine) herbal medicine in my country has very important social significance and economic value. Summary of the invention

[0005] The present invention provides a costus root oil liniment for treating myasthenia, a preparation method thereof and a use thereof, which overcome the deficiencies of the above-mentioned prior art. The costus root oil liniment has a certain therapeutic effect on myasthenia, and provides a new approach for the treatment of myasthenia.

[0006] One of the technical schemes of the present invention is achieved through the following measures: a costus root oil liniment for treating myasthenia, the medicinal materials comprising costus root, castoreum, black pepper, euphorbia resin, anachia root and olive oil, and the weight proportions are 35 to 70 parts of costus root, 12 to 24 parts of castoreum, 6 to 12 parts of black pepper, 6 to 12 parts of euphorbia resin and 12 to 24 parts of anachia root.

[0007] According to the formula principle of traditional Chinese medicine (Uyghur medicine), the functional characteristics of each traditional Chinese medicine (Uyghur medicine) component are: Aucklandia lappa: The local name is Kusitai, also known as Kusitai and Kuoer. It is the root of Aucklandialappa Decne, a plant of the Asteraceae family. This product is dry and hot in nature, pungent in taste, and has the functions of generating heat, dispelling wind and relieving pain, strengthening tendons and muscles, nourishing the brain and increasing intelligence, warming the middle and stimulating the appetite, dispersing qi and removing bloating, relieving asthma and relieving cough, nourishing the body and strengthening yang, removing spots and brightening the body, and expelling insects. It is mainly used to treat damp-cold or mucous diseases, such as joint pain, paralysis, facial paralysis, muscle weakness, brain deficiency and forgetfulness, stomach cold and poor appetite, qi stagnation and abdominal distension, asthma and cough, body deficiency and impotence, black spots and freckles, intestinal worms and other symptoms.

[0008] Castoreum: Also known as castoreum, the local medicine name is Kunduzi Kaiheri, and the alias is Zhundi Bidaistaier. It is the sachet secretion of the Eurasian beaver Castor Fiber L or the Canadian beaver Castr Canadensis Kuhe of the beaver family. This product is dry and hot at the third level and has a pungent taste. It has the functions of dryness and heat, nourishing the brain and spirit, dispelling cold and relieving asthma, dispelling wind and relieving tension, dispelling cold and dampness, relieving pain, calming the nerves and inducing hypnosis, regulating menstruation, and diuresis. It is mainly used to treat damp-cold or mucous encephalopathy, such as hysteria, epilepsy, asthma, tremors in the hands and feet, paralysis, rheumatic pain, dry headache, insomnia, cold amenorrhea, and urinary retention.

[0009] Black pepper: The local name is Karamuqi, also known as Pilipiliaisiwaid and Murjisiya. It is the dried nearly mature fruit of Pipernigrum L, a plant of the Piperaceae family. This product is dry and hot in nature, spicy in taste, and has the functions of drying and generating heat, nourishing the brain and relieving pain. It is mainly used to treat damp-cold or mucus diseases, such as stomach cold, poor appetite, indigestion, abdominal distension, cough with sputum, headache due to brain deficiency, toothache and other symptoms.

[0010] Euphorbia resin: Also known as Huoyangli, local medicine name Pairifeiyun, alias Aifeierbiyun, is the resinous secretion of Euphorbiaresinifera Berger, Euphorbiaceae. This product is dry and hot in nature, and has the functions of generating heat, clearing abnormal mucus, strengthening tendons and muscles, refreshing the brain and removing tightness, dispersing cold and relieving pain, drying dampness and reducing swelling, clearing intestinal obstruction, and removing cataracts. It is mainly used to treat damp-cold or mucus diseases, such as paralysis, facial paralysis, coma, convulsions, tremors, sciatica, joint pain, ascites, intestinal obstruction, cataracts and other diseases.

[0011] Anaqi root: also known as pyrethrum root, local medicine name Ake Ri Kai Ri Ha, alias Oduli Kai Ri He, Bihe Tai Er Hun, is the dried root of Anacyclus pyrethrum L DC, a plant of Asteraceae. This product is dry and hot in nature, spicy and numbing in taste, has the functions of generating heat, dispelling cold and strengthening tendons, opening blockages, clearing residual materials in the brain, warming up and strengthening yang, promoting menstruation, consolidating essence, dispelling wind and relieving pain, drying dampness and resolving phlegm, and nourishing nerves. It is mainly used to treat damp-cold or mucous diseases, such as paralysis, facial paralysis, muscle relaxation, paralysis, tremor, hysteria, tongue heaviness, loss of libido, loose semen, amenorrhea, headache, toothache, cough with phlegm, neurasthenia and other diseases.

[0012] Olive oil: produced by Xinjiang Xinlvbao Pharmaceutical Co., Ltd., production license: Xin 20160043, batch number: 20230101. It is routinely used in traditional Chinese medicine hospitals at all levels for patients with disuse myasthenia, and has the functions of promoting blood circulation and removing blood stasis, improving local blood circulation, and increasing muscle strength.

[0013] The costus root oil ointment for treating myasthenia, made according to the method of Chinese medicine (Uyghur medicine), has the functions of promoting blood circulation and removing blood stasis, improving local blood circulation, clearing abnormal odorless mucus at the neuromuscular junction, opening up mucous blockages, dispelling cold and dampness, generating heat, warming up and strengthening yang, strengthening tendons and muscles, and nourishing nerves. It is mainly used to treat damp-cold or abnormal odorless mucous diseases, such as myasthenia, weakness of tendons and muscles, muscle relaxation, flaccidity, facial paralysis, paralysis, cramps, tremors, hysteria, dementia and heavy tongue, low back pain and impotence, loss of libido, loose semen, neurasthenia, sciatica, joint pain, rheumatic pain, etc. The external costus root oil liniment for treating myasthenia of the present invention has a synergistic effect among the raw materials, wherein costus root mixed with olive oil is applied externally to treat paralysis and weakness of limbs; anachia root mixed with olive oil is applied externally to treat cramps and limb muscle sensory loss caused by cold; anachia root mixed with olive oil is applied to the whole body to induce sweating and strengthen limbs and tendons.

[0014] The costusroot oil liniment for treating myasthenia gravis of the present invention is safe and convenient to use, can be used for many kinds of diseases, has a wide application range, is quick to take effect, has definite therapeutic effect, has no side effects, has a simple preparation process, has low cost, has abundant sources of medicinal materials, and is worthy of popularization and application.

[0015] The following is a further optimization and / or improvement of one of the above-mentioned technical solutions: Preferably, the above-mentioned costusroot 35 parts, castoreum 12 parts, black pepper 6 parts, euphorbia resin 6 parts and anachia root 12 parts.

[0016] Preferably, the above-mentioned costusroot 52.5 parts, castoreum 18 parts, black pepper 9 parts, euphorbia resin 9 parts and anachia root 18 parts.

[0017] Preferably, the above-mentioned costusroot 70 parts, castoreum 24 parts, black pepper 12 parts, euphorbia resin 12 parts and anachia root 24 parts.

[0018] The costus root oil liniment for treating myasthenia is prepared by the following method: the medicinal materials costus root, castoreum, black pepper, euphorbia resin and anabaena root are crushed to obtain powdered costus root, castoreum, black pepper, euphorbia resin and anabaena root respectively; The required amount of powdered costus root, castoreum, black pepper, euphorbia resin and anachia root are uniformly mixed to obtain a mixed powder, olive oil is added to the mixed powder, and the mixture is rolled into a ball to obtain a costus root oil ointment for treating myasthenia gravis, wherein the amount of olive oil used is such that the mixed powder can be rolled into a ball.

[0019] The second technical solution of the present invention is achieved by the following measures: the preparation method of the costus root oil liniment for treating myasthenia described in the first technical solution is carried out as follows: the medicinal materials costus root, castoreum, black pepper, euphorbia resin and anabaena root are crushed respectively to obtain powdered costus root, castoreum, black pepper, euphorbia resin and anabaena root respectively; The required amount of powdered costus root, castoreum, black pepper, euphorbia resin and anachia root are uniformly mixed to obtain a mixed powder, olive oil is added to the mixed powder, and the mixture is rolled into a ball to obtain a costus root oil ointment for treating myasthenia gravis, wherein the amount of olive oil used is such that the mixed powder can be rolled into a ball.

[0020] The third technical solution of the present invention is achieved by the following measures: the use of the costus root oil liniment described in one of the technical solutions in the preparation of a drug for treating myasthenia gravis.

[0021] Each medicinal material in the prescription of the present invention is carefully selected after inheriting the clinical demonstration of local famous traditional Chinese medicine (Uyghur medicine) experts, and six natural medicines used for treating myasthenia in traditional medicine are organically combined to give full play to the combination effect of traditional Chinese medicine (Uyghur medicine). The medicine is safe and convenient to use, can be used for many types of diseases, has a wide range of use, is effective quickly, has definite, lasting and reliable efficacy, and has high patient compliance; compared with existing therapeutic drugs for myasthenia, it has no side effects, no drug resistance and physical dependence; the preparation process is simple, the cost is low, and it has certain market competitiveness; the source of medicinal materials is abundant, the quality can be guaranteed, and it is suitable for large-scale industrial production. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Attached Figure 1 The present invention is a flow chart of the preparation process of the costus root oil liniment for treating myasthenia gravis. DETAILED DESCRIPTION

[0023] The present invention is not limited by the following embodiments, and specific implementation methods can be determined according to the technical scheme of the present invention and actual conditions. The various chemical reagents and chemicals mentioned in the present invention, unless otherwise specified, are all chemical reagents and chemicals known and used in the prior art.

[0024] Table 1 is a comparison of the costus root oil liniment for treating myasthenia gravis of the present invention on the average muscle strength of the knee flexor muscles in a rat model of myasthenia gravis after sciatic nerve disuse injury.

[0025] Table 2 is a comparison of the costus root oil liniment for treating myasthenia gravis combined with basic stimulation rehabilitation therapy on the average muscle strength of the knee flexor muscles in a rat model of myasthenia gravis after sciatic nerve disuse injury.

[0026] Table 3 is a comparison of the costus root oil liniment for treating myasthenia gravis of the present invention on the average muscle strength of the ankle dorsiflexor muscles and active dorsiflexion PROM of the ankle joint in patients with myasthenia gravis caused by peripheral neuropathy (muscular dystrophy).

[0027] Notes for Tables 1 to 3: a Compared with the sham operation group, a P <0.05; bCompared with the model control group, b P <0.05; cCompared with the positive control group, c P <0.05; d Compared with the low-dose costus root oil group, d P <0.05; eCompared with the basic stimulation rehabilitation treatment group, e P <0.05; fCompared with the group before and after treatment, f P <0.05.

[0028] The present invention will be further described below in conjunction with embodiments: Embodiment 1: A costus root oil liniment for treating myasthenia, the medicinal materials comprising costus root, castoreum, black pepper, euphorbia resin, anahema root and olive oil, in parts by weight, comprising 35 to 70 parts of costus root, 12 to 24 parts of castoreum, 6 to 12 parts of black pepper, 6 to 12 parts of euphorbia resin and 12 to 24 parts of anahema root.

[0029] Embodiment 2: As the optimization of the above embodiment, 35 parts of costusroot, 12 parts of castoreum, 6 parts of black pepper, 6 parts of euphorbia resin and 12 parts of anaki root.

[0030] Example 3: As an optimization of the above Example 1, 52.5 parts of costusroot, 18 parts of castoreum, 9 parts of black pepper, 9 parts of euphorbia resin and 18 parts of anachia root.

[0031] Embodiment 4: As the optimization of the above-mentioned embodiment 1, 70 parts of costusroot, 24 parts of castoreum, 12 parts of black pepper, 12 parts of euphorbia resin and 24 parts of anaki root are added.

[0032] Example 5: The above-mentioned costus root oil liniment for treating myasthenia is prepared by the following method: the medicinal materials costus root, castoreum, black pepper, euphorbia resin and anabaena root are crushed respectively to obtain powdered costus root, castoreum, black pepper, euphorbia resin and anabaena root respectively; The required amount of powdered costus root, castoreum, black pepper, euphorbia resin and anachia root are uniformly mixed to obtain a mixed powder, olive oil is added to the mixed powder, and the mixture is rolled into a ball to obtain a costus root oil ointment for treating myasthenia gravis, wherein the amount of olive oil used is such that the mixed powder can be rolled into a ball.

[0033] The amount of olive oil used is enough to make the mixed powder clumping. Generally, the volume of olive oil added is twice the total mass of the powdered medicinal materials. For example, 150 ml of olive oil can be added to 70 grams of powdered medicinal materials (woodroot, castoreum, black pepper, euphorbia resin and anachia root).

[0034] Example 6: Use of the costus root oil liniment described in the above example in the preparation of a drug for treating myasthenia gravis.

[0035] Example 7: Figure 1 As shown, the costus root oil liniment for treating myasthenia is prepared according to the following method: the costus root, castoreum, black pepper and anachia root are selected, washed, dried, sterilized and crushed to obtain powdered costus root, castoreum, black pepper and anachia root respectively, and euphorbia resin is selected, ground and crushed to obtain powdered euphorbia resin; Mix 35 grams of powdered costus root, 12 grams of castoreum, 6 grams of black pepper, 6 grams of euphorbia resin and 12 grams of anaki root to obtain a mixed powder, add olive oil to the mixed powder, mix and form a lump to obtain a costus root oil ointment for treating myasthenia gravis, fill it into a clean container and set aside.

[0036] Example 8: A costus root oil liniment for treating myasthenia is prepared by the following method: the medicinal materials costus root, castoreum, black pepper and anabaena root are respectively selected, cleaned, dried, sterilized and crushed to obtain powdered costus root, castoreum, black pepper and anabaena root, and euphorbia resin is selected, ground and crushed to obtain powdered euphorbia resin; Mix 52.5 grams of powdered costus root, 18 grams of castoreum, 9 grams of black pepper, 9 grams of euphorbia resin and 18 grams of anaki root to obtain a mixed powder, add olive oil to the mixed powder, mix and form a lump to obtain a costus root oil ointment for treating myasthenia gravis, fill it into a clean container and set aside.

[0037] Example 9: A costus root oil liniment for treating myasthenia is prepared by the following method: the medicinal materials costus root, castoreum, black pepper and anabaena root are respectively selected, cleaned, dried, sterilized and crushed to obtain powdered costus root, castoreum, black pepper and anabaena root, and euphorbia resin is selected, ground and crushed to obtain powdered euphorbia resin; Mix 70 grams of powdered costus root, 24 grams of castoreum, 12 grams of black pepper, 12 grams of euphorbia resin and 24 grams of anaki root to obtain a mixed powder, add olive oil to the mixed powder, mix and form a lump to obtain a costus root oil ointment for treating myasthenia gravis, fill it into a clean container and set aside.

[0038] The animal experiments and clinical experiments of the costus root oil liniment of the present invention are as follows. The following costus root oil liniment all represent the costus root oil liniment for treating myasthenia gravis of the present invention.

[0039] 1. Animal experiments 1. Materials 1.1 Experimental materials: carotid artery rubber cannula (inner diameter 0.3 mm, length 2.5 mm), and other experimental materials.

[0040] 1.2 Experimental drugs 1.2.1 Traditional Chinese Medicine (Uyghur Medicine) External Application: Costus Root Oil Liniment. The dosage for rats was calculated based on the daily dosage for adults (60 kg) (10 ml per day, once a day). The dosage for rats of the Costus Root Oil Liniment of the present invention was 0.23 ml for the low-dose group, 0.468 ml for the medium-dose group, and 0.94 ml for the high-dose group. The Costus Root Oil Liniment used in the low-dose Costus Root Oil group, the medium-dose Costus Root Oil group, and the high-dose Costus Root Oil group was the Costus Root Oil Liniment for treating myasthenia prepared in Examples 7 to 9, respectively.

[0041] 1.2.2 Positive control drug: olive oil. Manufacturer: Xinjiang Xinlvbao Pharmaceutical Co., Ltd., production license: new 20160043, batch number: 20230101, valid for 3 years, 25ml / bottle. The rat dosage is calculated according to the daily dosage of an adult (60kg), and the rat dosage is 0.468ml.

[0042] 1.3 Experimental animals SD (Sparague-Dawley) rats, male, weighing 200±20g, were provided by the Animal Experiment Center of Xinjiang Medical University, ordinary grade animals, license: SYXK (New) 2018-0002, SCXK (New) 2018-0001. After the experimental animals were purchased, they were adaptively fed in the SPF environment of the animal room of the Animal Experiment Center of Xinjiang Medical University for 1 week, with a laboratory temperature of 25℃ and a humidity of 60%.

[0043] 2. Experimental Methods Healthy and clean SD male rats were randomly divided into 8 groups (n=8): sham operation group, model control group, positive control group, low-dose costus root oil group, medium-dose costus root oil group, high-dose costus root oil group, basic stimulation rehabilitation group (skin stimulation therapy, breathing massage stimulation therapy, warm stimulation therapy, hemiplegia stimulation therapy, micro-vibration stimulation therapy, balance stimulation therapy, exercise stimulation therapy, once a day, a total of 60 minutes), basic stimulation rehabilitation + high-dose costus root oil ointment group. The chronic sciatic nerve compression injury model designed by Mackinnon was used to replicate the rat model of disuse injury caused by chronic peripheral nerve compression required for this project (during the modeling surgery, the sham operation group was not ligated after the cannula, and the other steps were the same for all 8 groups). After waking up, continue to feed with ordinary feed for 6 weeks. After the modeling was successful, one rat was selected from each group for pre-intervention index detection. The other rats continued to be fed with ordinary feed, and the evaluation indicators were detected after 6 weeks of intervention.

[0044] Basic stimulation rehabilitation therapy includes: transcutaneous stimulation therapy, hemibody stimulation therapy, micro-vibration stimulation therapy, balance stimulation therapy, and treadmill exercise stimulation therapy, once a day for a total of 60 minutes.

[0045] 3. Index detection method A digital push-pull dynamometer (model: SH-111-50N) was used to detect the average muscle strength of the knee flexor muscles of the affected lower limb.

[0046] 4 Experimental Results 4.1 The efficacy of the costus root oil liniment on the sciatic nerve disuse myasthenia rat model is shown in Table 1.

[0047] As shown in Table 1, after intervention in the low-dose costus root oil group, the medium-dose costus root oil group, and the high-dose costus root oil group, the average muscle strength of the knee flexor muscles increased significantly, especially in the high-dose costus root oil group, where the increase effect was obvious.

[0048] 4.2 The efficacy of costus root oil liniment combined with basal stimulation rehabilitation therapy on the sciatic disuse myasthenia rat model is shown in Table 2.

[0049] The results in Table 2 prove that the costus root oil liniment for treating myasthenia gravis of the present invention further enhances the rehabilitation therapeutic effect of limb motor function, significantly increases the muscle strength of the affected limb (P<0.001), and plays a significant therapeutic role in preventing and treating lower limb weakness caused by sciatic nerve disuse injury.

[0050] 2. Clinical trials Patients with disuse myasthenia caused by peripheral neuropathy (muscular dystrophy) were selected from the hospital (there was no significant difference in age, gender, height, weight, education level and other general data). P <0.05), and were divided into a conventional rehabilitation group (n=19) and a conventional rehabilitation + costus root oil external application group (n=17) according to the random number table method, and different treatment methods were adopted for 6 weeks of intervention, and a randomized controlled clinical experimental study was carried out. The control group implemented conventional rehabilitation (massage therapy, large joint loosening training, occupational therapy, once a day, a total of 60 minutes); the experimental group implemented costus root oil liniment (costus root oil liniment for treating myasthenia prepared in Example 9) external application treatment and special hard scraping therapy on the basis of conventional rehabilitation, once a day, each time 10ml). The maximum muscle strength of the ankle dorsiflexor was detected by a neuromuscular stimulator (model: EN-Stim 4); the active dorsiflexion range of motion (PROM) of the ankle joint was detected by a virtual scenario interactive training system (model BioMaster).

[0051] The above clinical experimental results show that the costus root oil liniment for treating myasthenia gravis of the present invention further enhances the effect of conventional rehabilitation treatment, increases muscle strength and active range of motion (PROM) (both P <0.05), plays a significant therapeutic role in the prevention and treatment of myasthenia gravis and has great value for promotion and application.

[0052] In summary, the costus root oil liniment for treating myasthenia gravis of the present invention effectively improves the excitation-contraction coupling function of the neuromuscular junction, increases muscle strength, and improves the body's motor function, and has a good value for promotion and application; it provides a new approach for the treatment of myasthenia gravis.

[0053] The above technical features respectively constitute various embodiments of the present invention, which have strong adaptability and implementation effect. Non-essential technical features can be added or reduced according to actual needs to meet the requirements of different situations.

Claims

1. A costus root oil liniment for treating myasthenia, characterized in that The medicinal materials include costus root, castoreum, black pepper, euphorbia resin, anache root and olive oil. By weight, the costus root is 35 to 70 parts, the castoreum is 12 to 24 parts, the black pepper is 6 to 12 parts, the euphorbia resin is 6 to 12 parts and the anache root is 12 to 24 parts.

2. The costus root oil liniment for treating myasthenia according to claim 1, characterized in that 35 parts of costusroot, 12 parts of castoreum, 6 parts of black pepper, 6 parts of euphorbia resin and 12 parts of anachia root.

3. The costus root oil liniment for treating myasthenia according to claim 1, characterized in that 52.5 parts of costusroot, 18 parts of castoreum, 9 parts of black pepper, 9 parts of euphorbia resin and 18 parts of anaki root.

4. The costus root oil liniment for treating myasthenia according to claim 1, characterized in that 70 parts of costusroot, 24 parts of castoreum, 12 parts of black pepper, 12 parts of euphorbia resin and 24 parts of anaki root.

5. The costus root oil liniment for treating myasthenia according to claim 1, 2, 3 or 4, characterized in that The method is as follows: the medicinal materials costus root, castoreum, black pepper, euphorbia resin and anabasis root are crushed to obtain powdered costus root, castoreum, black pepper, euphorbia resin and anabasis root respectively; The required amount of powdered costus root, castoreum, black pepper, euphorbia resin and anachia root are uniformly mixed to obtain a mixed powder, olive oil is added to the mixed powder, and the mixture is rolled into a ball to obtain a costus root oil ointment for treating myasthenia gravis, wherein the amount of olive oil used is such that the mixed powder can be rolled into a ball.

6. A method for preparing the costus root oil liniment for treating myasthenia according to claim 1, characterized in that The method is as follows: the medicinal materials costus root, castoreum, black pepper, euphorbia resin and anabasis root are crushed respectively to obtain powdered costus root, castoreum, black pepper, euphorbia resin and anabasis root respectively; The required amount of powdered costus root, castoreum, black pepper, euphorbia resin and anachia root are uniformly mixed to obtain a mixed powder, olive oil is added to the mixed powder, and the mixture is rolled into a ball to obtain a costus root oil ointment for treating myasthenia gravis, wherein the amount of olive oil used is such that the mixed powder can be rolled into a ball.

7. The method for preparing the costus root oil liniment for treating myasthenia according to claim 6, characterized in that 35 parts of costusroot, 12 parts of castoreum, 6 parts of black pepper, 6 parts of euphorbia resin and 12 parts of anachia root.

8. The method for preparing the costus root oil liniment for treating myasthenia according to claim 6, characterized in that 52.5 parts of costusroot, 18 parts of castoreum, 9 parts of black pepper, 9 parts of euphorbia resin and 18 parts of anaki root.

9. The method for preparing the costus root oil liniment for treating myasthenia according to claim 6, characterized in that 70 parts of costusroot, 24 parts of castoreum, 12 parts of black pepper, 12 parts of euphorbia resin and 24 parts of anaki root.

10. Use of the costus root oil liniment for treating myasthenia according to any one of claims 1 to 5 in the preparation of a drug for treating myasthenia.

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