Medicinal and edible homology-based medicine component extraction and purification device and method

Abstract

The invention discloses a medicinal and edible homology-based medicine component extraction and purification device and method.The device comprises an extraction kettle, the interior of the extraction kettle is divided into a stirring area and a filtering area, the filtering area is a protruding partition plate, and the partition plate reciprocates in the vertical direction to pass through the stirring area and the filtering area; a plurality of through holes are formed in the middle of the partition plate, and filter screens and sealing assemblies are arranged in the through holes; the extraction kettle is divided into the stirring area and the filtering area through the partition plate, when the partition plate is located at the protruding position of the filtering area, an extracting solution can directly enter the filtering area, the pressure intensity of the filtering area is increased through the continuous partition plate, the sealing assembly is opened, and a passing channel is provided for the extracting solution for filtering work; and the separation plate can extrude the residues to discharge most of water in the residues, so that the production procedures are reduced, and meanwhile, the filtering efficiency of the extracting solution is greatly improved.

Description

Technical Field

[0001] The invention belongs to the technical field of drug extraction and purification, and in particular relates to a drug component extraction and purification device based on the homology of medicine and food, and a drug component extraction and purification method based on the homology of medicine and food. Background Art

[0002] "Medicine and food have the same origin" is an important concept in traditional Chinese medicine, which emphasizes that food and medicine are essentially the same. Many foods have medicinal value, and many medicines can also be eaten as food. Extracting and purifying the drug components in natural medicines or foods can remove harmful substances in natural medicines, reduce the presence of allergens, and improve the safety of drugs. The activity of purified drug components is clear, making it more convenient for ordinary people to take.

[0003] After the drug components are extracted using an organic solvent method, filtration is required to facilitate subsequent concentration. However, ordinary filtration methods require replacement into a specific container, which increases the production process and is prone to low filtration efficiency due to problems such as clogging. Summary of the invention

[0004] The present invention aims at solving the problems in the prior art and proposes the following technical solutions:

[0005] The drug ingredient extraction and purification device based on the homology of medicine and food includes:

[0006] An extraction kettle, wherein the interior of the extraction kettle is divided into a stirring zone and a filtering zone, the filtering zone is arranged in a convex shape, the extraction kettle is provided with a feed inlet at the top of the stirring zone, and the extraction kettle is provided with a liquid outlet and a slag outlet at the bottom of the filtering zone;

[0007] A partition plate, the partition plate reciprocates in the vertical direction through the stirring zone and the filtering zone, two upper and lower sealing rings are arranged on the outer side of the partition plate, a plurality of through holes are opened in the middle of the partition plate, and a filter screen and a sealing component are arranged inside the through holes;

[0008] After stirring is completed, the partition plate enters the filtration area from the bottom of the stirring area. The extract falls into the bottom of the filtration area when the partition plate is at the protrusion of the filtration area. The partition plate continues to move so that the sealing component opens under the action of pressure to provide a passage for the extract. The residue is blocked by the filter net and cannot pass through for filtration. After the partition plate cannot continue to move, the sealing component is automatically closed to facilitate the discharge of the filtrate.

[0009] As a preferred embodiment of the above technical solution, the sealing component includes a sealing plug, and a return spring is fixedly connected between the sealing plug and the through hole.

[0010] As a preferred embodiment of the above technical solution, the closing component further comprises a leveling plate, the top of the leveling plate is flush with the top of the partition plate, and the leveling plate is fixedly connected to a fixing block fixedly connected to the sealing plug.

[0011] As a preferred embodiment of the above technical solution, an auxiliary hole is provided on one side of the through hole, the auxiliary hole is located between the upper and lower sealing rings, and the auxiliary hole is used to discharge the extraction liquid inside the through hole.

[0012] As a preferred embodiment of the above technical solution, the end of the sealing plug is truncated into a cone shape, and the corresponding position of the through hole matches the sealing plug.

[0013] As a preferred embodiment of the above technical solution, a connecting rod is provided at the bottom of the partition plate, one end of the connecting rod passes through the extraction kettle and extends to the outside, and the end of the connecting rod is connected to an external power device.

[0014] As a preferred embodiment of the above technical solution, it also includes a stirring mechanism, which is located in the stirring zone of the extraction kettle and is used to stir the raw materials.

[0015] The working method of the drug component extraction and purification device based on the homology of medicine and food comprises the following steps:

[0016] S1, raw material pretreatment;

[0017] The raw materials are crushed to a particle size of less than 1 mm, and then soaked or dried;

[0018] S2, organic solvent extraction;

[0019] The pretreated raw materials are injected into the extraction kettle, and a proper amount of organic solvent is added and the container is sealed. After mixing and stirring, the mixture is allowed to stand to form an extract.

[0020] S3, stirring and filtering;

[0021] The partition plate enters the filtration zone from the bottom of the stirring zone so that the extract falls into the bottom of the filtration zone when the partition plate is at the protrusion of the filtration zone. The partition plate continues to move so that the sealing component opens under pressure to provide a passage for the extract, and the residue is blocked by the filter screen and cannot pass through for filtration.

[0022] S4, concentration;

[0023] The filtered extract is concentrated by evaporation or rotary evaporation to remove the solvent to obtain a concentrated solution;

[0024] S5, purification;

[0025] The concentrated extract is passed through a purification device, and the concentrate is purified by column chromatography, thin layer chromatography, or the like;

[0026] S6, recrystallization;

[0027] The purified drug component is dissolved in a suitable solvent, and the drug component is recrystallized by slow cooling or adding seed crystals to obtain high-quality crystals.

[0028] The beneficial effects of the present invention are:

[0029] 1. The extraction kettle is separated into a stirring zone and a filtering zone by a partition plate. After the extract is mixed and extracted in the stirring zone, the partition plate moves downward to complete the multi-stage work. When the partition plate is at the protrusion of the filtering zone, the extract can directly enter the filtering zone. After the partition plate leaves the protrusion of the filtering zone, the continued partition plate increases the pressure in the filtering zone to open the sealing component, providing a passage for the extract to pass through for filtering. In addition, the partition plate can squeeze the residue to discharge most of the water in the residue, thereby reducing the production process and greatly improving the filtering efficiency of the extract.

[0030] 2. The sealing component can block the through hole in one direction, and can automatically open it by pressure change to perform filtering work. In addition, the sealing component can keep the top of the partition plate flat, which can prevent the extract in the stirring area from entering the filtering area and preventing the extraction work from being performed normally.

[0031] 3. The auxiliary hole can guide the residual filtrate in the through hole to between the two sealing rings. After the partition plate moves up to the liquid outlet position, all the filtrate of the same batch can be discharged and collected to avoid the long-term residual filtrate affecting the quality of subsequent drug production. BRIEF DESCRIPTION OF THE DRAWINGS

[0032] Figure 1 What is shown is a schematic diagram of the overall structure of the embodiment;

[0033] Figure 2 Shown is a front cross-sectional view of an embodiment;

[0034] Figure 3 What is shown is the state diagram of the extract entering the filtration area in the embodiment;

[0035] Figure 4 What is shown is the filtering state diagram of the extract in the embodiment;

[0036] Figure 5 In the embodiment shown Figure 4 Enlarged view of part A.

[0037] In the figure: 10, extraction kettle; 11, stirring zone; 12, feed port; 13, filtering zone; 14, liquid outlet; 15, slag outlet; 20, partition plate; 21, through hole; 22, filter screen; 30, connecting rod; 40, sealing ring; 50, closing assembly; 51, sealing plug; 52, return spring; 53, leveling plate; 54, fixing block; 60, auxiliary hole. DETAILED DESCRIPTION

[0038] In order to make the purpose, technical solution and advantages of the embodiments of the present invention more clear, the technical solution of the present invention will be clearly and completely described below in conjunction with the embodiments and the accompanying drawings of the specification.

[0039] Figure 1-Figure 5 The drug component extraction and purification device based on the homology of medicine and food includes:

[0040] An extraction kettle 10, wherein the interior of the extraction kettle 10 is divided into a stirring zone 11 and a filtering zone 13, wherein the filtering zone 13 is convexly arranged, wherein the extraction kettle 10 is provided with a feed inlet 12 at the top of the stirring zone 11, and wherein the extraction kettle 10 is provided with a liquid outlet 14 and a slag outlet 15 at the bottom of the filtering zone 13;

[0041] A partition plate 20, the partition plate 20 reciprocates in the vertical direction through the stirring zone 11 and the filtering zone 13, two upper and lower sealing rings 40 are arranged on the outer side of the partition plate 20, a plurality of through holes 21 are opened in the middle of the partition plate 20, and a filter screen 22 and a sealing component 50 are arranged inside the through holes 21;

[0042] After stirring is completed, the partition plate 20 enters the filtration area 13 from the bottom of the stirring area 11. The extract falls into the bottom of the filtration area 13 when the partition plate 20 is at the protrusion of the filtration area 13. The partition plate 20 continues to move so that the sealing component 50 opens under the action of pressure to provide a passage for the extract. The residue is blocked by the filter net 22 and cannot pass through for filtration. After the partition plate 20 cannot continue to move, the sealing component 50 is automatically closed to facilitate the discharge of the filtrate.

[0043] A connecting rod 30 is disposed at the bottom of the partition plate 20 , one end of the connecting rod 30 passes through the extraction kettle 10 and extends to the outside, and the end of the connecting rod 30 is connected to an external power device.

[0044] The pretreated raw material is injected into the extraction kettle 10, and then a proper amount of organic solvent is added for mixing and stirring. After standing for a period of time, the external power device drives the partition plate 20 to move down and away from the bottom of the stirring area 11 through the connecting rod 30. When the partition plate 20 is at the protrusion of the filtering area 13, the extract falls along both sides of the partition plate 20 to the bottom of the filtering area 13 to enter the filtering stage. After the partition plate 20 continues to move down and away from the protrusion of the filtering area 13, the movement of the partition plate 20 increases the internal pressure of the filtering area 13, and the sealing component 50 opens accordingly to open the through hole 21, and the extraction The liquid can be filtered through the filter mesh 22 to form filtered liquid and collected at the top of the partition plate 20, while the residue is collected at the bottom of the partition plate 20. The partition plate 20 can squeeze the residue and discharge most of the water in the residue until the partition plate 20 can no longer move. The closing component 50 automatically resets to block the through hole 21. After the residue outlet 15 is opened to take out the residue, the external power device can push the connecting rod 30 and the partition plate 20 to move upward. After the top of the partition plate 20 and the bottom of the liquid outlet 14 are reached, the liquid outlet 14 can be opened to carry out subsequent treatment of the filtered liquid.

[0045] The extraction kettle 10 is divided into a stirring zone 11 and a filtering zone 13 by a partition plate 20. After the extract is mixed and extracted in the stirring zone 11, the partition plate 20 moves downward to complete the multi-stage work. When the partition plate 20 is at the protrusion of the filtering zone 13, the extract can directly enter the filtering zone 13. After the partition plate 20 leaves the protrusion of the filtering zone 13, the continued partition plate 20 increases the pressure in the filtering zone 13 to open the sealing component 50, providing a passage for the extract to pass through for filtering, and the partition plate 20 can squeeze the residue to discharge most of the water in the residue, thereby reducing the production process and greatly improving the filtering efficiency of the extract.

[0046] The working method of the drug component extraction and purification device based on the homology of medicine and food comprises the following steps:

[0047] S1, raw material pretreatment;

[0048] The raw materials are crushed to a particle size of less than 1 mm, and then soaked or dried;

[0049] S2, organic solvent extraction;

[0050] The pretreated raw material is injected into the extraction kettle 10, and a proper amount of organic solvent is added and the container is sealed. After mixing and stirring, the mixture is allowed to stand to form an extract.

[0051] S3, filtering;

[0052] The partition plate 20 enters the filtering area 13 from the bottom of the stirring area 11 so that the extract falls into the bottom of the filtering area 13 when the partition plate 20 is at the protrusion of the filtering area 13. The partition plate 20 continues to move so that the sealing component 50 opens under the action of pressure to provide a passage for the extract, and the residue is blocked by the filter screen 22 and cannot pass through for filtration;

[0053] S4, concentration;

[0054] The filtered extract is concentrated by evaporation or rotary evaporation to remove the solvent to obtain a concentrated solution;

[0055] S5, purification;

[0056] The concentrated extract is passed through a purification device, and the concentrate is purified by column chromatography, thin layer chromatography, or the like;

[0057] S6, recrystallization;

[0058] The purified drug component is dissolved in a suitable solvent, and the drug component is recrystallized by slow cooling or adding seed crystals to obtain high-quality crystals.

[0059] Figure 2-Figure 5 In the embodiment, the sealing assembly 50 includes a sealing plug 51 , and a return spring 52 is fixedly connected between the sealing plug 51 and the through hole 21 .

[0060] The end of the sealing plug 51 is truncated into a cone shape, and the corresponding position of the through hole 21 matches the sealing plug 51 .

[0061] The closing assembly 50 further includes a leveling piece 53 , the top of which is flush with the top of the partition plate 20 , and the leveling piece 53 is fixedly connected to a fixing block 54 which is fixedly connected to the sealing plug 51 .

[0062] When the partition plate 20 moves and the pressure in the filter area 13 increases, the sealing plug 51 is moved away from the bottom position of the through hole 21 due to the pressure, and the return spring 52 is compressed and deformed accordingly, and the fixing block 54 drives the leveling plate 53 to leave the top position of the through hole 21, and the through hole 21 can be opened to allow the extract to be filtered through the filter net 22. After the partition plate 20 squeezes the residue, the pressure at the bottom of the filter area 13 no longer changes, and the return spring 52 can reset the sealing plug 51 and the leveling plate 53, and part of the filtered liquid remains in the through hole 21.

[0063] The provided sealing component 50 can unidirectionally block the through hole 21, and can automatically open by pressure change for filtering. Moreover, the sealing component 50 can keep the top of the partition plate 20 flat, and can prevent the extraction liquid in the stirring area 11 from entering the filtering area 13 and preventing the extraction from being performed normally.

[0064] Figure 2-Figure 5 In the embodiment, an auxiliary hole 60 is provided on one side of the through hole 21 . The auxiliary hole 60 is located between the upper and lower sealing rings 40 . The auxiliary hole 60 is used to discharge the extraction liquid inside the through hole 21 .

[0065] When the extract is filtered, part of the filtrate enters and leaves the through hole 21 from the auxiliary hole 60 on one side of the through hole 21, and the filtrate that leaves is gathered between the two sealing rings 40. When the closing assembly 50 is closed, the partition plate 20 moves up to move the through hole 21 to the position of the liquid outlet 14, and the filtrate gathered between the sealing rings 40 and remaining in the through hole 21 can be discharged through the liquid outlet 14.

[0066] The auxiliary hole 60 can guide the residual filtrate in the through hole 21 to between the two sealing rings 40. After the partition plate 20 moves up to the liquid outlet 14, all the filtrate of the same batch can be discharged and collected to avoid the filtrate remaining for a long time and affecting the quality of subsequent drug production.

[0067] The extraction kettle 10 further comprises a stirring mechanism, which is located in the stirring zone 11 of the extraction kettle 10 and is used for stirring the raw materials.

[0068] The above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit them.

Claims

1. A drug component extraction and purification device based on the homology of medicine and food, characterized in that: include: An extraction kettle (10), wherein the interior of the extraction kettle (10) is divided into a stirring zone (11) and a filtering zone (13), wherein the filtering zone (13) is arranged in a convex shape, and the extraction kettle (10) is provided with a feed inlet (12) at the top of the stirring zone (11), and a liquid outlet (14) and a slag outlet (15) at the bottom of the filtering zone (13); A partition plate (20), the partition plate (20) reciprocatingly moves in a vertical direction through the stirring zone (11) and the filtering zone (13), two upper and lower sealing rings (40) are arranged on the outer side of the partition plate (20), a plurality of through holes (21) are opened in the middle of the partition plate (20), and a filter screen (22) and a sealing component (50) are arranged inside the through holes (21); The partition plate (20) enters the filtering area (13) from the bottom of the stirring area (11), and the extract falls into the bottom of the filtering area (13) when the partition plate (20) is at the protrusion of the filtering area (13). The partition plate (20) continues to move so that the sealing component (50) opens under the action of pressure to provide a passage for the extract, and the residue is blocked by the filter net (22) and cannot pass through for filtering. After the partition plate (20) cannot move further, the sealing component (50) is automatically closed to facilitate the discharge of the filtered liquid.

2. The drug component extraction and purification device based on the homology of medicine and food according to claim 1 is characterized in that: The sealing assembly (50) comprises a sealing plug (51), and a return spring (52) is fixedly connected between the sealing plug (51) and the through hole (21).

3. The drug component extraction and purification device based on the homology of medicine and food according to claim 2 is characterized in that: The closure assembly (50) further comprises a leveling plate (53), the top of which is flush with the top of the partition plate (20), and the leveling plate (53) is fixedly connected to a fixing block (54) which is fixedly connected to the sealing plug (51).

4. The drug component extraction and purification device based on the homology of medicine and food according to claim 1 is characterized in that: An auxiliary hole (60) is provided on one side of the through hole (21), and the auxiliary hole (60) is located between the upper and lower sealing rings (40). The auxiliary hole (60) is used to discharge the extraction liquid inside the through hole (21).

5. The drug component extraction and purification device based on the homology of medicine and food according to claim 2 is characterized in that: The end of the sealing plug (51) is arranged in a truncated cone shape, and the corresponding position of the through hole (21) matches the sealing plug (51).

6. The drug component extraction and purification device based on the homology of medicine and food according to claim 1 is characterized in that: A connecting rod (30) is provided at the bottom of the partition plate (20), one end of the connecting rod (30) passes through the extraction kettle (10) and extends to the outside, and the end of the connecting rod (30) is connected to an external power device.

7. The drug component extraction and purification device based on the homology of medicine and food according to claim 2 is characterized in that: It also comprises a stirring mechanism, which is located in the stirring zone (11) of the extraction kettle (10) and is used to stir the raw materials.

8. The working method of the drug component extraction and purification device based on the homology of medicine and food according to any one of claims 1 to 7, characterized in that: The following steps are involved: S1, raw material pretreatment; The raw materials are crushed to a particle size of less than 1 mm, and then soaked or dried; S2, organic solvent extraction; The pretreated raw material is injected into an extraction kettle (10), and a proper amount of organic solvent is added and the container is sealed. After mixing and stirring, the mixture is allowed to stand to form an extract. S3, stirring and filtering; The partition plate (20) enters the filtering area (13) from the bottom of the stirring area (11) so that the extract falls into the bottom of the filtering area (13) when the partition plate (20) is at the protrusion of the filtering area (13). The partition plate (20) continues to move so that the sealing component (50) opens under the action of pressure to provide a passage for the extract, and the residue is blocked by the filter screen (22) and cannot pass through for filtering; S4, concentration; The filtered extract is concentrated by evaporation or rotary evaporation to remove the solvent to obtain a concentrated solution; S5, purification; The concentrated extract is passed through a purification device, and the concentrate is purified by column chromatography, thin layer chromatography, or the like; S6, recrystallization; The purified drug component is dissolved in a suitable solvent, and the drug component is recrystallized by slow cooling or adding seed crystals to obtain high-quality crystals.

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