Cigarette containing traditional Chinese medicines and preparation method thereof

Abstract

The invention belongs to the technical field of tobaccos, and particularly relates to a cigarette containing traditional Chinese medicine and a preparation method of the cigarette. The traditional Chinese medicine is prepared from the following components in parts by mass: 150 to 200 parts of radix ophiopogonis, 130 to 180 parts of rhizoma atractylodis macrocephalae, 100 to 150 parts of herba cistanche, 40 to 80 parts of radix ginseng, 20 to 60 parts of radix codonopsis, 20 to 40 parts of roxburgh rose, 10 to 20 parts of white poria, 10 to 20 parts of agilawood and 5 to 15 parts of mulberry bark. According to the traditional Chinese medicine, the radix ophiopogonis, the rhizoma atractylodis macrocephalae and the herba cistanche serve as monarch drugs, the ginseng, the radix codonopsis and the rosa roxburghii serve as ministerial drugs, the white poria cocos and the agilawood of aquilaria agallocha serve as adjuvant drugs, and the mulberry bark serves as a conductant drug, so that the cigarette containing the traditional Chinese medicine has the effects of expelling phlegm to arrest coughing, and the efficacy stability of the cigarette is improved through the tobacco shreds loaded with the amphiphilic cellulose porous material.

Description

Technical Field

[0001] The invention belongs to the technical field of tobacco, and in particular relates to a cigarette containing traditional Chinese medicine and a preparation method thereof. Background Art

[0002] As we all know, cigarettes release a large amount of harmful substances when they burn. These harmful substances are inhaled into the human body and adhere to the tracheal walls and alveoli, which can easily lead to bronchitis, emphysema, and even lung cancer. However, due to the presence of addictive chemicals in cigarettes, quitting smoking is a painful, repetitive and long process, and most smokers are unable to quit smoking completely.

[0003] In order to reduce the harm of cigarettes, in recent years, cigarettes containing Chinese medicine have been continuously studied. For example, the Chinese patent with publication number CN113519891A discloses a medicinal cigarette and its preparation method and equipment. The cigarette includes tobacco shreds filled in the cigarette, and the tobacco shreds are composed of the following Chinese medicinal raw materials in weight proportions: 5-20 parts of ginkgo leaves, 5-20 parts of ginseng leaves, 5-20 parts of lily leaves, 5-20 parts of tea leaves, 5-20 parts of wolfberry leaves, 5-20 parts of red date leaves, 5-20 parts of Sichuan fritillaria leaves, 5-20 parts of loquat leaves; 3-10 parts of tangerine peel; 3-10 parts of astragalus extract, 5-15 parts of polygonatum extract, 3-10 parts of chuanxiong extract, and 2-10 parts of licorice extract. The medicinal cigarette of this technical solution can not only retain the shape and taste of the cigarette, but also can be brewed and drunk, and at the same time has the effects of moistening the lungs and nourishing yin, regulating the five internal organs, and refreshing the mind. However, this technical solution uses Chinese medicinal materials as tobacco, and has many ingredients, which may affect the stability of the cigarette.

[0004] A Chinese patent with publication number CN103190694B discloses a Chinese herbal medicine extract, its preparation method, use, and prepared tobacco and cigarettes. The Chinese herbal medicine extract is prepared from agarwood, platycodon and licorice. The technical solution mixes the Chinese herbal medicine extract with tobacco to make cigarettes. When smoking, the extract evaporates into the smoke at high temperature and is inhaled by the smoker, thereby achieving the purpose of health care. The cigarette has a pleasant aroma, can reduce the irritation of the smoker's throat by cigarettes, eliminate the bad smell of the smoker's mouth, and has anti-inflammatory, lung-moistening and anti-tumor effects. However, the technical solution directly mixes the Chinese herbal medicine extract with tobacco, and the stability of the Chinese herbal medicine extract may be different from the properties of the tobacco, which may cause the mixed product to change in efficacy after storage. Summary of the invention

[0005] In view of the above problems, the present invention provides a cigarette containing traditional Chinese medicine and a preparation method thereof. The traditional Chinese medicine of the present invention comprises ophiopogon japonicus, atractylodes macrocephala and cistanche deserticola as main medicines, ginseng, codonopsis pilosula and roxburghii as assistant medicines, white tuckahoe and agarwood as adjuvant medicines, and mulberry bark as guiding medicine, so that the cigarette containing traditional Chinese medicine has the effect of removing phlegm and relieving cough, and the efficacy stability of the cigarette is improved by loading tobacco shreds of amphiphilic cellulose porous material.

[0006] To achieve the above purpose, the technical solution adopted by the present invention is as follows:

[0007] The first aspect of the present invention provides a cigarette containing traditional Chinese medicine, comprising tobacco shreds loaded with an amphiphilic cellulose porous material and traditional Chinese medicine; the traditional Chinese medicine, measured by weight, comprises: 150-200 parts of ophiopogon japonicus, 130-180 parts of atractylodes macrocephala, 100-150 parts of cistanche deserticola, 40-80 parts of ginseng, 20-60 parts of codonopsis pilosula, 20-40 parts of roxburghii, 10-20 parts of white tuckahoe, 10-20 parts of agarwood, and 5-15 parts of mulberry bark.

[0008] Preferably, the content of the traditional Chinese medicine is 1-10% of the weight of the tobacco, preferably 8%.

[0009] Preferably, the traditional Chinese medicine comprises, by weight: 180 parts of Ophiopogon japonicus, 160 parts of Atractylodes macrocephala, 130 parts of Cistanche deserticola, 60 parts of Ginseng, 40 parts of Codonopsis pilosula, 30 parts of Rosa roxburghii, 15 parts of White Poria, 15 parts of Aquilaria sinensis, and 10 parts of Morus bark.

[0010] Preferably, the method for preparing shredded tobacco loaded with amphiphilic cellulose porous material comprises the following steps: stirring tobacco dust, adhesive, water and amphiphilic cellulose porous material to obtain tobacco sheet slurry, pressing the tobacco sheet slurry into sheets, roll-forming the sheets, drying and shaping the rolled sheets, and cutting them into shreds.

[0011] Preferably, the method for preparing the amphiphilic cellulose porous material comprises the following steps: mixing the nanocellulose suspension and KH580 (γ-mercaptopropyltriethoxysilane), stirring, and freeze-drying to obtain the amphiphilic cellulose porous material.

[0012] Preferably, the nanocellulose suspension is obtained by dispersing cellulose nanofibers and cellulose nanowhiskers in water at a mass ratio of 3-5:1.

[0013] Preferably, the cellulose nanofibers are carboxylated cellulose nanofibers with a diameter of 4-10 nm and a length of 1-3 μm.

[0014] Preferably, the cellulose nanowhiskers have a diameter of 4-10 nm and a length of 100-500 nm.

[0015] Preferably, the concentration of the nanocellulose suspension A is 1-3 wt %.

[0016] Preferably, the mass ratio of the cellulose nanofibers, cellulose nanowhiskers and KH580 is 3-5:1:2-3, preferably 4:1:3.

[0017] Preferably, in the method for preparing the amphiphilic cellulose porous material, the stirring temperature is 25-40° C., and the stirring time is 2-4 h.

[0018] Preferably, in the method for preparing the amphiphilic cellulose porous material, the freeze-drying temperature is -60 to -40°C, and the freeze-drying time is 24 to 48 hours.

[0019] Preferably, the tobacco dust includes one or more of flue-cured tobacco dust, sun-cured tobacco dust, oriental tobacco dust, and burley tobacco dust.

[0020] Preferably, the adhesive comprises one or more of xanthan gum, chitosan, sodium alginate and guar gum.

[0021] Preferably, the mass ratio of the tobacco dust, the binder, the water and the amphiphilic cellulose porous material is 15-25:3-8:57-77:1-5, preferably 20:5:67:3.

[0022] Preferably, in the method for preparing tobacco shreds loaded with amphiphilic cellulose porous material, the stirring temperature is 25-30° C. and the stirring time is 20-40 min.

[0023] The second aspect of the present invention provides a method for preparing the above-mentioned cigarette, comprising the following steps:

[0024] S1. Grind Radix Ophiopogonis, Rhizoma Atractylodis Macrocephalae, Herba Cistanches and Aquilariae Linn. respectively, add ethanol aqueous solution, soak, heat and reflux for extraction, and obtain extract I and volatile oil I;

[0025] S2, crushing ginseng and roxburghii, adding purified water, soaking, heating and refluxing to extract, and obtaining extract II and volatile oil II;

[0026] S3, mix Codonopsis pilosula, white Poria cocos and mulberry bark, add purified water, soak, heat extract 1-2 times, combine the filtrate to obtain extract III;

[0027] S4, mixing volatile oil I and volatile oil II to obtain volatile oil III; mixing extract III, extract II and extract III to obtain extract IV;

[0028] S5. Firstly, spray the volatile oil III on the surface of the tobacco shreds, and then spray the extract IV on the surface of the tobacco shreds after drying, and then make cigarettes according to the conventional cigarette process after drying.

[0029] Preferably, S1 is specifically: crushing Ophiopogon japonicus, Atractylodes macrocephala, Cistanche deserticola, and Aquilaria sinensis respectively, adding 8-12 times (corresponding to the total mass of Ophiopogon japonicus, Atractylodes macrocephala, Cistanche deserticola, and Aquilaria sinensis) of ethanol aqueous solution, soaking at 50-70° C. for 1-2 h, heating and refluxing for extraction for 8-12 h, to obtain extract I and volatile oil I;

[0030] Preferably, the volume concentration of the ethanol aqueous solution is 85-95%.

[0031] Preferably, S2 is specifically: crushing ginseng and roxburghii, adding 8-12 times (corresponding to the total mass of ginseng and roxburghii) of purified water, soaking at 50-70° C. for 1-2 hours, heating under reflux for extraction for 8-12 hours, and obtaining extract II and volatile oil II;

[0032] Preferably, S3 is specifically: mixing Codonopsis pilosula, white Poria cocos, and mulberry bark, adding 8-12 times (corresponding to the total mass of Codonopsis pilosula, white Poria cocos, and mulberry bark) of purified water, soaking at 50-70°C for 1-2h, extracting at a heat extraction temperature of 90-100°C for 1-2h for the first time, filtering the first extract, collecting the filtrate, adding 6-8 times of purified water to the filter residue, extracting at a heat extraction temperature of 90-100°C for 1-2h for the second time, filtering the second extract,

[0033] The filtrates were collected and the two filtrates were combined to obtain extract III.

[0034] Compared with the prior art, the present invention has the following beneficial effects:

[0035] 1. The Chinese medicine of the present invention uses Radix Ophiopogonis, Atractylodes macrocephala and Cistanche deserticola as the main drugs. Radix Ophiopogonis belongs to the heart meridian, lung meridian and stomach meridian, moistens the lungs and clears the heart, relieves heat and promotes fluid production, resolves phlegm and stops vomiting, and treats cough and diuresis; Atractylodes macrocephala belongs to the spleen and stomach meridian, strengthens the spleen and replenishes qi, eliminates dampness and promotes diuresis; Cistanche deserticola belongs to the kidney and large intestine meridian, resolves phlegm and stops cough, and improves lung heat cough and asthma; Ginseng, Codonopsis pilosula and Rosa roxburghii are the assistant drugs. Ginseng belongs to the spleen, lung and heart meridians, nourishes the spleen and benefits the lungs, and can help Radix Ophiopogonis moisten the lungs and clear the heart, resolve phlegm and stop cough; Codonopsis pilosula belongs to the spleen meridian, Lung meridian, tonifies the middle, replenishes qi, promotes fluid production, and benefits the lungs, assists Atractylodes macrocephala in strengthening the spleen and replenishing qi; Rosa roxburghii belongs to the spleen, kidney, and stomach meridians, and can assist Cistanche deserticola in moistening the lungs, resolving phlegm, and relieving cough; White Poria cocos and Kynam agarwood are adjuvants, White Poria cocos belongs to the heart, lung, spleen, and kidney meridians, promotes diuresis and eliminates dampness, strengthens the spleen and calms the mind, Kynam agarwood regulates qi, relieves pain, and opens the orifices, assists Ophiopogon japonicus in moistening the lungs and clearing the heart, and Atractylodes macrocephala in strengthening the spleen and replenishing qi; Mulberry bark is a messenger, leading its monarch and ministers into its meridians, entering the lung meridian and spleen meridian, draining the lungs and relieving asthma, promoting water flow and reducing swelling.

[0036] 2. The Chinese medicine of the present invention uses Radix Ophiopogonis, Atractylodes Macrocephala and Cistanche deserticola volatile oil as main ingredients, which cooperate with other ingredients to make the cigarette containing the Chinese medicine have the effect of removing phlegm and relieving cough.

[0037] 3. The present invention uses tobacco shreds loaded with amphiphilic cellulose porous materials to improve the efficacy stability of cigarettes. DETAILED DESCRIPTION

[0038] The present invention is further explained below in conjunction with specific embodiments. It should be understood that the specific embodiments described herein are only used to illustrate and explain the present invention, and are not used to limit the present invention.

[0039] In the following examples, unless otherwise specified, all raw materials used were commercially available or prepared by conventional methods in the art.

[0040] Example 1

[0041] A cigarette containing Chinese medicine, comprising tobacco shreds loaded with amphiphilic cellulose porous materials and Chinese medicine; the content of the Chinese medicine is 1% of the weight of the tobacco shreds, and the Chinese medicine, by weight, consists of 150 parts of Ophiopogon japonicus, 130 parts of Atractylodes macrocephala, 100 parts of Cistanche deserticola, 40 parts of Ginseng, 20 parts of Codonopsis pilosula, 20 parts of Rosa roxburghii, 10 parts of White Poria, 10 parts of Aquilaria sinensis, and 5 parts of Morus alba.

[0042] The preparation method of tobacco shreds loaded with amphiphilic cellulose porous material comprises the following steps: burley tobacco dust, xanthan gum, water and amphiphilic cellulose porous material are stirred at a mass ratio of 15:3:77:1, the stirring temperature is 25°C, the stirring time is 20 minutes, tobacco sheet slurry is obtained, the tobacco sheet slurry is pressed into thin sheets, the thin sheets are roll-formed, the rolled thin sheets are dried, shaped and shredded.

[0043] The preparation method of the amphiphilic cellulose porous material comprises the following steps: mixing a nanocellulose suspension (the nanocellulose suspension is obtained by dispersing cellulose nanofibers and cellulose nanowhiskers in a mass ratio of 3:1 in water, and the concentration is 1wt%) and KH580, stirring at 25°C for 2h, and freeze-drying at -60°C for 24h to obtain the obtained material.

[0044] The cellulose nanofibers are carboxylated cellulose nanofibers with a diameter of 4-10 nm and a length of 1-3 μm, which are purchased from Guilin Qihongke Co., Ltd.

[0045] The cellulose nano whiskers have a diameter of 4-10 nm and a length of 100-500 nm and are purchased from Guilin Qihongke Co., Ltd.

[0046] The mass ratio of the cellulose nanofibers, the cellulose nanowhiskers and KH580 is 3:1:2.

[0047] The method for preparing the above-mentioned cigarette comprises the following steps:

[0048] S1. Grind Ophiopogon japonicus, Atractylodes macrocephala, Cistanche deserticola, and Aquilaria sinensis respectively, add 8 times (corresponding to the total mass of Ophiopogon japonicus, Atractylodes macrocephala, Cistanche deserticola, and Aquilaria sinensis) of 90% ethanol aqueous solution by volume, soak at 50°C for 1 hour, heat under reflux for extraction for 8 hours, and obtain extract I and volatile oil I;

[0049] S2, crush ginseng and roxburghii, add 8 times (corresponding to the total mass of ginseng and roxburghii) purified water, soak at 50°C for 1 hour, heat under reflux for extraction for 8 hours, and obtain extract II and volatile oil II;

[0050] S3. Mix Codonopsis pilosula, White Poria cocos and Morus alba, add 8 times (corresponding to the total mass of Codonopsis pilosula, White Poria cocos and Morus alba) of purified water, soak at 50°C for 1 hour, perform the first hot extraction at 90°C for 1 hour, filter the first extract, collect the filtrate, add 6 times of purified water to the residue, perform the second hot extraction at 90°C for 1 hour, filter the second extract, collect the filtrate, and combine the two filtrates to obtain extract III.

[0051] S4, mixing volatile oil I and volatile oil II to obtain volatile oil III; mixing extract III, extract II and extract III to obtain extract IV;

[0052] S5. Firstly, spray the volatile oil III on the surface of the tobacco shreds, and then spray the extract IV on the surface of the tobacco shreds after drying, and then make cigarettes according to the conventional cigarette process after drying.

[0053] Example 2

[0054] A cigarette containing Chinese medicine, comprising tobacco shreds loaded with amphiphilic cellulose porous materials and Chinese medicine; the content of the Chinese medicine is 10% of the weight of the tobacco shreds, and the Chinese medicine, by weight, consists of 200 parts of Ophiopogon japonicus, 180 parts of Atractylodes macrocephala, 150 parts of Cistanche deserticola, 80 parts of Ginseng, 60 parts of Codonopsis pilosula, 40 parts of Rosa roxburghii, 20 parts of White Poria, 20 parts of Aquilaria sinensis, and 15 parts of Morus alba.

[0055] The preparation method of tobacco shreds loaded with amphiphilic cellulose porous material comprises the following steps: burley tobacco dust, xanthan gum, water and amphiphilic cellulose porous material are stirred at a mass ratio of 25:8:57:5, the stirring temperature is 30°C, the stirring time is 40 minutes, tobacco sheet slurry is obtained, the tobacco sheet slurry is pressed into sheets, the sheets are roll-formed, the rolled sheets are dried, shaped and shredded.

[0056] The preparation method of the amphiphilic cellulose porous material comprises the following steps: mixing a nanocellulose suspension (the nanocellulose suspension is obtained by dispersing cellulose nanofibers and cellulose nano whiskers in water at a mass ratio of 5:1, with a concentration of 3wt%) and KH580, stirring at 40°C for 4h, and freeze-drying at -40°C for 48h to obtain the obtained material.

[0057] The cellulose nanofibers are carboxylated cellulose nanofibers with a diameter of 4-10 nm and a length of 1-3 μm, which are purchased from Guilin Qihongke Co., Ltd.

[0058] The cellulose nano whiskers have a diameter of 4-10 nm and a length of 100-500 nm and are purchased from Guilin Qihongke Co., Ltd.

[0059] The mass ratio of the cellulose nanofibers, the cellulose nanowhiskers and KH580 is 5:1:3.

[0060] The method for preparing the above-mentioned cigarette comprises the following steps:

[0061] S1. Grind Ophiopogon japonicus, Atractylodes macrocephala, Cistanche deserticola, and Aquilaria sinensis respectively, add 12 times (corresponding to the total mass of Ophiopogon japonicus, Atractylodes macrocephala, Cistanche deserticola, and Aquilaria sinensis) of 90% ethanol aqueous solution by volume, soak at 70°C for 2h, heat under reflux for extraction for 12h, and obtain extract I and volatile oil I;

[0062] S2, crush ginseng and roxburghii, add 12 times (corresponding to the total mass of ginseng and roxburghii) purified water, soak at 70°C for 2h, heat under reflux for 12h, and obtain extract II and volatile oil II;

[0063] S3. Mix Codonopsis pilosula, White Poria cocos and Morus alba, add 12 times (corresponding to the total mass of Codonopsis pilosula, White Poria cocos and Morus alba) purified water, soak at 70°C for 2h, perform the first hot extraction at 100°C for 2h, filter the first extract, collect the filtrate, add 8 times purified water to the residue, perform the second hot extraction at 100°C for 2h, filter the second extract, collect the filtrate, and combine the two filtrates to obtain extract III.

[0064] S4, mixing volatile oil I and volatile oil II to obtain volatile oil III; mixing extract III, extract II and extract III to obtain extract IV;

[0065] S5. Firstly, spray the volatile oil III on the surface of the tobacco shreds, and then spray the extract IV on the surface of the tobacco shreds after drying, and then make cigarettes according to the conventional cigarette process after drying.

[0066] Example 3

[0067] A cigarette containing Chinese medicine, comprising tobacco shreds loaded with amphiphilic cellulose porous materials and Chinese medicine; the content of the Chinese medicine is 10% of the weight of the tobacco shreds, and the Chinese medicine, by weight, consists of 180 parts of Ophiopogon japonicus, 160 parts of Atractylodes macrocephala, 130 parts of Cistanche deserticola, 60 parts of Ginseng, 40 parts of Codonopsis pilosula, 30 parts of Rosa roxburghii, 15 parts of White Poria, 15 parts of Aquilaria sinensis, and 10 parts of Morus alba.

[0068] The preparation method of tobacco shreds loaded with amphiphilic cellulose porous material comprises the following steps: burley tobacco dust, xanthan gum, water and amphiphilic cellulose porous material are stirred at a mass ratio of 20:5:67:3, the stirring temperature is 30°C, the stirring time is 30 minutes, tobacco sheet slurry is obtained, the tobacco sheet slurry is pressed into sheets, the sheets are roll-formed, the rolled sheets are dried, shaped and shredded.

[0069] The preparation method of the amphiphilic cellulose porous material comprises the following steps: mixing a nanocellulose suspension (the nanocellulose suspension is obtained by dispersing cellulose nanofibers and cellulose nano whiskers in a mass ratio of 4:1 in water, with a concentration of 2wt%) and KH580, stirring at 35°C for 3h, and freeze-drying at -50°C for 36h to obtain the obtained material.

[0070] The cellulose nanofibers are carboxylated cellulose nanofibers with a diameter of 4-10 nm and a length of 1-3 μm, which are purchased from Guilin Qihongke Co., Ltd.

[0071] The cellulose nano whiskers have a diameter of 4-10 nm and a length of 100-500 nm and are purchased from Guilin Qihongke Co., Ltd.

[0072] The mass ratio of the cellulose nanofibers, the cellulose nanowhiskers and KH580 is 4:1:3.

[0073] The method for preparing the above-mentioned cigarette comprises the following steps:

[0074] S1. Grind Ophiopogon japonicus, Atractylodes macrocephala, Cistanche deserticola, and Aquilaria odorifera respectively, add 10 times (corresponding to the total mass of Ophiopogon japonicus, Atractylodes macrocephala, Cistanche deserticola, and Aquilaria odorifera) of 90% ethanol aqueous solution by volume, soak at 60°C for 1.5h, heat under reflux for extraction for 10h, and obtain extract I and volatile oil I;

[0075] S2, crush ginseng and roxburghii, add 10 times (corresponding to the total mass of ginseng and roxburghii) purified water, soak at 60°C for 1.5h, heat and reflux for 10h, and obtain extract II and volatile oil II;

[0076] S3. Mix Codonopsis pilosula, White Poria cocos and Morus alba, add 10 times (corresponding to the total mass of Codonopsis pilosula, White Poria cocos and Morus alba) purified water, soak at 65°C for 1.5 h, perform the first hot extraction at 100°C for 1.5 h, filter the first extract, collect the filtrate, add 8 times purified water to the residue, perform the second hot extraction at 100°C for 1.5 h, filter the second extract, collect the filtrate, and combine the two filtrates to obtain extract III.

[0077] S4, mixing volatile oil I and volatile oil II to obtain volatile oil III; mixing extract III, extract II and extract III to obtain extract IV;

[0078] S5. Firstly, spray the volatile oil III on the surface of the tobacco shreds, and then spray the extract IV on the surface of the tobacco shreds after drying, and then make cigarettes according to the conventional cigarette process after drying.

[0079] Comparative Example 1

[0080] The difference from Example 3 is that only the Cistanche deserticola is replaced with ginseng of equal mass, and the rest are the same.

[0081] Comparative Example 2

[0082] The difference from Example 3 is that only ginseng is replaced with liquorice of the same mass, and the rest are the same.

[0083] Comparative Example 3

[0084] The difference from Example 3 is that only the agarwood is replaced with white Poria cocos of equal mass, and the rest are the same.

[0085] Comparative Example 4

[0086] The difference from Example 4 is that only the mulberry peel is replaced with tangerine peel of equal quality, and the rest are the same.

[0087] Comparative Example 5

[0088] The difference from Example 3 is that the method for preparing the cigarette comprises the following steps:

[0089] S1. Mix Ophiopogon japonicus, Atractylodes macrocephala, Cistanche deserticola, Aquilaria sinensis, ginseng, Rosa roxburghii, Codonopsis pilosula, white Poria cocos, and mulberry bark, add 10 times (corresponding to the total mass of Ophiopogon japonicus, Atractylodes macrocephala, Cistanche deserticola, Aquilaria sinensis, ginseng, Rosa roxburghii, Codonopsis pilosula, white Poria cocos, and mulberry bark) purified water, soak at 70°C for 2h, extract at 100°C for 2h for the first time, filter the first extract, collect the filtrate, add 8 times purified water to the residue, extract at 100°C for 2h for the second time, filter the second extract, collect the filtrate, and combine the two filtrates to obtain an extract.

[0090] S2. Spray the extract on the surface of the shredded tobacco, and after drying, make cigarettes using conventional cigarette technology.

[0091] Comparative Example 6

[0092] The difference from Example 3 is that only the tobacco shreds loaded with the amphiphilic cellulose porous material are replaced with burley tobacco shreds of the same mass, and the rest are the same.

[0093] Comparative Example 7

[0094] The difference from Example 3 is that only the amphiphilic cellulose porous material is replaced by a cellulose porous material of equal mass, and the rest are the same. The preparation method of the cellulose porous material is as follows: the nanocellulose suspension (the nanocellulose suspension is obtained by dispersing cellulose nanofibers and cellulose nanowhiskers in a mass ratio of 4:1 in water, and the concentration is 2wt%) is freeze-dried at -50°C for 36 hours.

[0095] Comparative Example 8

[0096] The difference from Example 3 is that the cigarette is made from tobacco shreds loaded with amphiphilic cellulose porous material (the content of amphiphilic cellulose porous material is 3% of the mass of tobacco shreds) using conventional cigarette technology.

[0097] Comparative Example 9

[0098] The difference from Example 3 is that the method for preparing the cigarette comprises the following steps:

[0099] S1. Grind Ophiopogon japonicus, Atractylodes macrocephala, Cistanche deserticola, and Aquilaria odorifera respectively, add 10 times (corresponding to the total mass of Ophiopogon japonicus, Atractylodes macrocephala, Cistanche deserticola, and Aquilaria odorifera) of 90% ethanol aqueous solution by volume, soak at 60°C for 1.5h, heat under reflux for extraction for 10h, and obtain extract I and volatile oil I;

[0100] S2, crush ginseng and roxburghii, add 10 times (corresponding to the total mass of ginseng and roxburghii) purified water, soak at 60°C for 1.5h, heat and reflux for 10h, and obtain extract II and volatile oil II;

[0101] S3. Mix Codonopsis pilosula, White Poria cocos and Morus alba, add 10 times (corresponding to the total mass of Codonopsis pilosula, White Poria cocos and Morus alba) purified water, soak at 65°C for 1.5 h, perform the first hot extraction at 100°C for 1.5 h, filter the first extract, collect the filtrate, add 8 times purified water to the residue, perform the second hot extraction at 100°C for 1.5 h, filter the second extract, collect the filtrate, and combine the two filtrates to obtain extract III.

[0102] S4, mixing volatile oil I and volatile oil II to obtain volatile oil III; mixing extract III, extract II and extract III to obtain extract IV, reducing the concentration of extract IV to a relative density of 1.1 (50° C.) to obtain a thick extract, drying and crushing to obtain an extract;

[0103] S5. First, spray the volatile oil III on the surface of the tobacco shreds, and then mix the extract and the tobacco shreds after drying to make cigarettes according to the conventional cigarette process.

[0104] Experimental Example 1: Antitussive and Expectorant Experiment

[0105] 1. Experimental Animals

[0106] SPF grade Kunming mice, half male and half female, weighing 20±5g, were provided by Liaoning Changsheng Biotechnology Co., Ltd.

[0107] 2. Experimental methods

[0108] 2.1 Grouping

[0109] The mice were randomly divided into a blank group, Example 1-3 groups, and Comparative Example 1-9 groups, with 10 mice in each group, half of which were male and half were female.

[0110] 2.2 Experiments

[0111] The blank group was raised normally without fumigation, and the Example 1-3 group and the Comparative Example 1-9 group were placed in a fumigation wooden box, and two cigarettes of the Example 1-3 group and the Comparative Example 1-9 group were lit each time and placed on the mosquito coil plate in the wooden box, twice a day, each time for 30 minutes. The following tests were performed after 30 days of fumigation:

[0112] (1) 30 minutes after the last experiment, the number of coughs of mice was observed within 5 minutes and the number of coughs of mice in each group was recorded.

[0113] (2) After the last experiment, 6 mice were taken from each group and injected intraperitoneally with 10 mL / kg of IP 5% phenol red solution. The mice were killed 30 minutes later, the tracheal segment was separated, and the thyroid cartilage was taken to the tracheal branch, cut into pieces, and placed in a test tube containing 4 mL of 5% NaHCO3 solution. The tube was immersed for 4 h and centrifuged at 3000 r / min for 15 min. The supernatant was taken and placed at a wavelength of 546 nm to measure the OD value. The phenol red content was calculated using the phenol red standard curve.

[0114] 2.3 Statistical methods

[0115] All data were analyzed using SPSS 22.0 statistical software. The comparison among the groups was performed by one-way analysis of variance, and P < 0.05 was considered statistically significant.

[0116] 3. Experimental results

[0117] Table 1 Results of cough and expectorant experiments

[0118]

[0119] As can be seen from Table 1, there is a significant difference between the comparative example 8 group and the blank group, indicating that the modeling is successful; there are significant differences between the antitussive effect and the expectorant effect of the embodiment 1-3 group, the comparative example 6-7 group and the comparative example 9 group and the comparative example 8 group; there is no significant difference between the comparative example 1-5 group and the comparative example 8 group, indicating that the embodiment 1-3 group, the comparative example 6-7 group and the comparative example 9 group can effectively relieve cough and expectorate.

[0120] The difference between Comparative Examples 1-4 and Example 3 is that the types of medicinal materials are different, and the difference between Comparative Example 5 and Example 1 is that the preparation methods of the drugs in the cigarettes are different. The drugs are all in the form of water extracts. It can be concluded that in the present invention, the types and preparation methods of Chinese medicines both affect the antitussive and expectorant effects of cigarettes.

[0121] Experimental Example 2: Stability Experiment

[0122] The cigarettes of Example 1-3 and Comparative Example 6-9 were placed under natural conditions for 12 months, and then the same experiment as Experimental Example 1 was conducted to evaluate their stability through the cough-relieving and expectorant effects.

[0123] Table 2 Cough and expectorant results after 12 months of placement

[0124]

[0125] It can be seen from Table 2 that there is a significant difference between the comparative example 8 group and the blank group, indicating that the modeling is successful; after being placed under natural conditions for 6 months, there are significant differences between the antitussive effect and expectorant effect of the embodiment 1-3 groups and the comparative example 8 group; there is no significant difference between the comparative example 6-7 group and the comparative example 9 group and the comparative example 8 group, indicating that the cigarettes of the embodiment 1-3 groups have good stability.

[0126] The difference between Comparative Examples 6-7 and Example 3 is that the tobacco in the cigarettes is different, and the difference between Comparative Example 9 and Example 3 is that the preparation method of the cigarettes is different (the mixing method of the traditional Chinese medicine and the tobacco is different). It can be concluded that in the present invention, the tobacco loaded with the amphiphilic cellulose porous material and the preparation method both affect the antitussive and expectorant effects of the cigarettes.

[0127] Finally, it should be noted that the above content is only used to illustrate the technical solution of the present invention, rather than to limit the scope of protection of the present invention. Simple modifications or equivalent substitutions of the technical solution of the present invention by ordinary technicians in this field do not deviate from the essence and scope of the technical solution of the present invention.

Claims

1. A cigarette containing Chinese medicine, characterized in that: It includes tobacco and traditional Chinese medicine loaded with amphiphilic cellulose porous materials; The Chinese medicine comprises, by weight, 150-200 parts of Ophiopogon japonicus, 130-180 parts of Atractylodes macrocephala, 100-150 parts of Cistanche deserticola, 40-80 parts of Ginseng, 20-60 parts of Codonopsis pilosula, 20-40 parts of Rosa roxburghii, 10-20 parts of White Poria, 10-20 parts of Aquilaria sinensis, and 5-15 parts of Morus bark.

2. The cigarette according to claim 1, characterized in that The Chinese medicine comprises, by weight, 180 parts of Ophiopogon japonicus, 160 parts of Atractylodes macrocephala, 130 parts of Cistanche deserticola, 60 parts of Ginseng, 40 parts of Codonopsis pilosula, 30 parts of Rosa roxburghii, 15 parts of White Poria, 15 parts of Aquilaria sinensis, and 10 parts of Morus bark.

3. The cigarette according to claim 2, characterized in that The content of the traditional Chinese medicine is 1-10% of the mass of the tobacco.

4. The cigarette according to any one of claims 1 to 3, characterized in that: The method for preparing tobacco shreds loaded with amphiphilic cellulose porous materials comprises the following steps: mixing tobacco dust, adhesive, water and amphiphilic cellulose porous materials to obtain tobacco sheet slurry, pressing the tobacco sheet slurry into sheets, rolling the sheets into shapes, drying and shaping the rolled sheets, and cutting the sheets into shreds.

5. The cigarette according to claim 4, characterized in that The preparation method of the amphiphilic cellulose porous material comprises the following steps: mixing the nanocellulose suspension and KH580, stirring, and freeze-drying to obtain the material.

6. The cigarette according to claim 5, characterized in that The nanocellulose suspension is obtained by dispersing cellulose nanofibers and cellulose nano whiskers in water at a mass ratio of 3-5:

1. 7 . The cigarette according to claim 6 , wherein the mass ratio of the cellulose nanofibers, the cellulose nanowhiskers and KH580 is 3-5:1:2-3.

8. The cigarette according to claim 7, characterized in that The cellulose nanofiber is a carboxylated cellulose nanofiber with a diameter of 4-10 nm and a length of 1-3 μm; the cellulose nano whisker has a diameter of 4-10 nm and a length of 100-500 nm.

9. The cigarette according to claim 8, characterized in that The mass ratio of the tobacco dust, the adhesive, the water and the amphiphilic cellulose porous material is 15-25:3-8:57-77:1-5.

10. The method for preparing a cigarette according to any one of claims 1 to 9, characterized in that: The following steps are involved: S1. Grind Radix Ophiopogonis, Rhizoma Atractylodis Macrocephalae, Herba Cistanches and Aquilariae Linn. respectively, add ethanol aqueous solution, soak, heat and reflux for extraction, and obtain extract I and volatile oil I; S2, crushing ginseng and roxburghii, adding purified water, soaking, heating and refluxing to extract, and obtaining extract II and volatile oil II; S3, mix Codonopsis pilosula, white Poria cocos and mulberry bark, add purified water, soak, heat extract 1-2 times, combine the filtrate to obtain extract III; S4, mixing volatile oil I and volatile oil II to obtain volatile oil III; mixing extract I, extract II and extract III to obtain extract IV; S5. Firstly, spray the volatile oil III on the surface of the tobacco shreds, and then spray the extract IV on the surface of the tobacco shreds after drying, and then make cigarettes after drying.

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