Improved milk mineral salt and application thereof in oral care product

Abstract

The invention discloses improved milk mineral salt and application of the improved milk mineral salt in oral care products, and the improved milk mineral salt comprises milk mineral salt and amino acid; wherein the mass ratio of the amino acid to the milk mineral salt is (1: 49)-(2: 1), preferably (1: 19)-(1: 1). A test on a toothpaste product prepared from the improved milk mineral salt provided by the invention shows that the microhardness of the demineralized hydroxyapatite is obviously increased, and the mineralized surface becomes compact and smoother and has reduced pits through observation under a scanning electron microscope, so that the toothpaste product is proved to be more uniform after the toothpaste is mineralized on the demineralized hydroxyapatite surface. The damaged part is repaired, and meanwhile, the acid corrosion resistance is improved.

Description

Technical Field

[0001] The invention belongs to the field of oral care, and in particular relates to a modified milk mineral salt and application thereof in oral care products. Background Art

[0002] The human oral environment is very complex. In addition to the common mechanical behavior caused by chewing, the outermost layer of the tooth enamel is often subjected to acid erosion caused by endogenous or exogenous acidic media, which in turn induces excessive wear of the teeth. Tooth enamel has no nerves and blood vessels, and cannot regenerate after being damaged. Excessive wear of teeth can damage the enamel surface. If the damage is mild, periodontitis and gingival atrophy will occur; if it is severe, the dental tubules will be exposed, the teeth will be allergic, causing the patient to feel sore and painful, and making the teeth more susceptible to bacterial erosion and tooth decay. Therefore, for contemporary oral medical workers who emphasize minimally invasive treatment, inhibiting the demineralization of early caries and promoting its remineralization must be the focus of caries prevention tasks.

[0003] In daily oral care, fluoride toothpaste is currently commonly used to increase tooth hardness to prevent caries. However, excessive use of fluoride toothpaste may cause fluoride poisoning, thereby damaging the nervous system and inducing osteoporosis. In addition, in recent years, various raw materials that promote remineralization have continued to appear in caries prevention work and research, such as calcium fluoride nanoparticles, calcium phosphate nanoparticles, nano-bioactive glass, casein phosphopeptide nanocomplexes, etc. For well-known reasons, the safety of these materials is far less than that of milk mineral salts directly derived from animal milk.

[0004] Milk mineral salts, also known as milk calcium, whey mineral concentrate, and whey calcium, are made from animal milk whey, extracted through purification, ultrafiltration, and drying processes. Among the ingredients contained, calcium mainly exists in the form of calcium phosphate. At present, milk mineral salts are widely used in food as a nutritional enhancer, and no adverse research reports have been found during decades of use. Considering its good safety record, source, and high-quality calcium source, it is introduced into the field of oral care and studied in order to improve the safety of remineralization materials. Summary of the invention

[0005] The object of the present invention is to provide a modified milk mineral salt and application thereof in oral care products, wherein the modified milk mineral salt has a precise tooth remineralization effect and good safety.

[0006] The purpose of the present invention is achieved through the following technical solutions: An improved milk mineral salt comprises milk mineral salt and amino acids, wherein the mass ratio of the amino acids to the milk mineral salt is 1:19-2:1, preferably 1:2-2:1.

[0007] The amino acid is one or more of alanine, valine, leucine, isoleucine, phenylalanine, tryptophan, tyrosine, aspartic acid, asparagine, glycine, glutamic acid, lysine, glutamine, methionine, serine, threonine, cysteine, proline, histidine, arginine or cystine.

[0008] Preferably, the amino acid is one or more of arginine, glutamic acid, cysteine, cysteine, aspartic acid, asparagine, methionine, threonine and serine.

[0009] In the process of oral mineralization, providing sufficient amounts of active calcium ions and phosphate ions at the same time is an indispensable factor, and the ratio of calcium ions to phosphate ions needs to be close to 1.64-1.68.

[0010] Experiments show that milk mineral salts have low solubility in water, so the concentrations of ionized calcium and phosphate ions are also relatively low.

[0011] For example, in a 1% milky mineral salt dispersion, only about 1% of the milky mineral salt is ionized. When this material is directly applied to toothpaste, it is confirmed through laboratory simulated mineralization experiments that it has no obvious mineralization ability.

[0012] In order to make milk mineral salts ionize calcium ions, if acidic substances such as dilute hydrochloric acid, sulfuric acid, citric acid, dilute nitric acid, acetic acid, and phosphoric acid are added, ionization can be slightly promoted, but the national standard for oral care products requires that the pH value must be controlled above 5.5 (5.5~10.5). Therefore, it is impossible to add a lot of acidic materials without limit in a specific product. For example, dilute hydrochloric acid, dilute nitric acid, and dilute phosphoric acid are added to a 1% milk mineral salt dispersion to control the pH value to about 5.0, and about 23% of the milk mineral salts are ionized. Experimental verification shows that the calcium and phosphate ions produced by this method are not enough for effective self-mineralization reactions on teeth. Similarly, commonly used chelating substances produce even fewer calcium and phosphate ions and are also inappropriate.

[0013] After exploration and repeated research, it was found that if a certain amount of amino acids were added to milk mineral salts, the solubility of milk mineral salts in water could be significantly improved. For example, when selected amino acids were added to a 1% milk mineral salt dispersion and the pH value was adjusted to about 5.0, about 27% or more of the milk mineral salts were ionized; and as calcium phosphate ions were deposited and mineralized on the teeth and consumed, the milk mineral salts would continue to release calcium and phosphorus ions, allowing the milk mineral salts to continuously provide calcium and phosphorus atoms in the oral cavity, realizing the biological self-mineralization process of active calcium and phosphate ions being used, produced, and mineralized in the oral cavity. Therefore, the oral care product made by using the improved milk mineral salt of the present invention has a good effect of remineralizing teeth.

[0014] The modified milk mineral salt can be used in oral care products; the modified milk mineral salt can be a premixed milk mineral salt and amino acid, or the milk mineral salt and amino acid can be added separately to the oral care product; The oral care products include toothpaste, chewing granules, chewing gum, tooth tablets, tooth powder, mouthwash, oral spray and the like.

[0015] A toothpaste comprising the following ingredients: Friction agent: 0~60.0% Fragrance: 0.001~2.0% Moisturizer: 0~80.0% Sweetener: 0.01~5.0% Surfactant: 0.01~4.0% Preservatives: 0~0.8% Thickener: 0.05~10.0% Soluble phosphate: 0.02~1.0% Improved milk mineral salt: 0.1~50.0% Food coloring: appropriate amount Deionized water: Balance.

[0016] The friction agent includes one or more of silicon dioxide, hydrated silica, calcium hydrogen phosphate (such as anhydrous calcium hydrogen phosphate or calcium hydrogen phosphate dihydrate), calcium phosphate, calcium carbonate, microcrystalline cellulose, calcium pyrophosphate, aluminum hydroxide, aluminum oxide, magnesium carbonate, magnesium phosphate, zeolite powder, hydroxyapatite, ceramic powder, and nut shell powder; The moisturizing agent is selected from one or more of sorbitol, ethylene glycol, polyethylene glycol, glycerol, propylene glycol, butylene glycol, xylitol, pentylene glycol, hexylene glycol, 1,2-hexanediol, polypropylene glycol, mannose or mannitol, isomannide, maltose or maltitol, erythrose or erythritol, and sodium phytate; The sweetener includes one or more substances that can produce sweetness, such as sucralose, sodium saccharin, stevioside, potassium glycyrrhizinate, perilla sugar, erythrose, acesulfame potassium, and aspartame; The surfactant includes one or more of anionic surfactants, cationic surfactants, nonionic surfactants and zwitterionic surfactants; The preservative is selected from one or more of benzyl alcohol, sodium benzoate, potassium sorbate, p-hydroxybenzoate, sodium diacetate, propylparaben and its salt, p-hydroxyacetophenone, hexylene glycol, triclosan, DMDM ​​hydantoin, o-cymene-5-ol (IPMP), notoginseng extract, grapefruit extract, aloe extract, honeysuckle extract, wild chrysanthemum extract, scutellaria baicalensis extract, gallnut extract, Imperata root extract, Angelica dahurica extract, pine needle extract, tea polyphenols, paeonol, and cationic fungicides; The thickener is selected from substances capable of thickening the system, such as carrageenan, xanthan gum, xanthan gum, cellulose gum, methyl cellulose, sodium carboxymethyl cellulose, ethyl cellulose, cellulose acetate, sodium ethyl cellulose, sodium alginate, arabic resin, locust bean gum, guar gum, modified guar gum, gellan gum, gelatin, cassia seed gum, tamarind seed gum, aloe vera gel, polyvinyl alcohol, sodium polyacrylate, carboxyvinyl polymer, carbomer resin, silica gel, thickening silicon dioxide, lithium magnesium silicate, magnesium aluminum silicate, gum, and arabic gum; The soluble phosphate is selected from monophosphate (sodium, potassium, or ammonium salt) or polyphosphate (potassium, sodium, ammonium salt) or other phosphate substances.

[0017] Of course, according to the theory and practice of oral care products, other functional materials can also be added to the formula, such as sodium monofluorophosphate, sodium fluoride, vitamins, vitamin esters, tranexamic acid, zinc citrate, zinc gluconate, sodium chloride, etc., as long as one or more substances meet safety standards.

[0018] The preparation method of the toothpaste includes but is not limited to the following steps: S1: placing a thickener and a moisturizer in a paste-making pot and stirring to obtain a first material; S2: placing a sweetener, a preservative and an appropriate amount of water in a premixing pot and stirring to obtain a second material; S3: placing the second material into the first material and stirring to obtain a third material; S4: adding abrasive and improved milk mineral salt to the third material and stirring to obtain a fourth material; S5: placing the remaining water and soluble phosphate in a premixing pot and stirring to obtain a fifth material; S6: placing the fifth material into the fourth material and stirring to obtain a sixth material; S7: placing a surfactant in the sixth material and stirring to obtain a seventh material; S8. Place essence and an appropriate amount of food coloring into the seventh material, stir and homogenize for 15 to 30 minutes under a vacuum environment to obtain toothpaste.

[0019] Compared with the prior art, the present invention has the following advantages and effects: 1. The improved milk mineral salt of the present invention generates self-mineralized ions while being used in the oral cavity, which greatly broadens the functional scope of the milk mineral salt.

[0020] 2. The improved milk mineral salt of the present invention does not undergo mineralization reaction during the preparation and storage process, thus avoiding the stringent requirement that other mineralized materials (such as calcium sodium silicate and active glass) must be used in anhydrous formulas (if there is water in the formula, the active material will react with water first and lose its activity before use). Therefore, the formula and production costs are greatly reduced, and it has extremely high economic and social benefits. The undissolved part of the improved milk mineral salt of the present invention can be used as an abrasive to help clean dental plaque without waste.

[0021] 3. Milk mineral salt crystals are porous and irregular, and its calcium phosphate crystals are mixed with a small amount of protein, amino acids, trace elements and other substances in breast milk, so it is more conducive to the mineralization reaction of the present invention under the addition of amino acids; the inventors found in experiments that when industrially produced calcium phosphate or calcium hydrogen phosphate is used and amino acids are added to improve it, it cannot release sufficient amounts of calcium and phosphate ions.

[0022] 4. The toothpaste product made by using the improved milk mineral salt provided by the present invention was tested. The microhardness of the hydroxyapatite after demineralization was significantly increased. Under the scanning electron microscope, the surface became denser and smoother after mineralization, and the pits were reduced. This proves that after the toothpaste was applied to the surface of the demineralized hydroxyapatite for mineralization, the damaged parts were repaired and the acid corrosion resistance was improved. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 These are the SEM results of hydroxyapatite ceramic pieces after pretreatment (demineralization).

[0024] Figure 2 This is the SEM result of the hydroxyapatite ceramic sheet after being treated with toothpaste in Example 2.

[0025] Figure 3 This is the SEM result of the hydroxyapatite ceramic sheet after being treated with toothpaste in Example 3.

[0026] Figure 4 This is the SEM result of the hydroxyapatite ceramic sheet after being treated with toothpaste in Example 4.

[0027] Figure 5 It is the SEM result of the hydroxyapatite ceramic sheet after being treated with the comparative toothpaste. DETAILED DESCRIPTION

[0028] The present invention is further described in detail below in conjunction with embodiments and drawings, but the embodiments of the present invention are not limited thereto.

[0029] Example 1 The degree of ionization of milk mineral salts under different acidic substances is shown in Table 1 and Table 2: Table 1: Ionization degree of milk mineral salt under different acidic substances

[0030] Table 2 Ionization degree of milk mineral salt under different amino acid substances

[0031] Method for determining the degree of ionization of milk mineral salts: Step 1: Prepare the dispersion according to the serial number and stir for 15 minutes; Step 2: Filter under reduced pressure, wash the filter residue three times with a small amount of pure water, and take the filtrate; Step 3: Add excess sodium carbonate solution and stir for 5 minutes; Step 4: Filter, wash the filter residue and filter paper three times with a large amount of pure water, put the filter residue, filter paper and a clean filter paper of the same specification into the oven at the same time, dry at 105℃, weigh the total weight of the filter residue and filter paper, and get m 总 ; Weigh the weight of the dried clean filter paper and get m 滤纸 ; Calculate the filter residue weight m 滤渣 =m 总 -m 滤纸 .

[0032] Calculation of the degree of ionization of milk mineral salts using the filter residue as calcium carbonate : ; By comparing the experiments of sequence numbers 1, 4, 5, 6, 7, 9, 10, 11, 12, 13, 14, and 15, it can be seen that with the addition of the selected amino acids, the pH value of the dispersion decreased, the degree of ionization of the milk mineral salt increased, and the amount of precipitate in the filtrate increased, indicating that the addition of the selected amino acids can promote the ionization of the milk mineral salt, and the ionized calcium ions can produce precipitates after a period of time due to changes in the external environment; Comparing the experiments No. 2 and 3 with No. 4, 5, 6-15, we can see that when the pH value of the dispersion is similar, the degree of ionization of the mineral salt in the test milk with the addition of the selected amino acid is higher, and the filtrate can produce a precipitate, indicating that the effect of adding acidic substances such as dilute hydrochloric acid and citric acid to promote ionization is weaker than that of adding the selected amino acid, and the calcium ions ionized thereby do not produce a precipitate, and the basis for the remineralization effect does not exist; By comparing serial numbers 6 and 8, and serial numbers 15 and 16, it can be seen that when the same proportion of selected amino acids is added, the degree of ionization of milk mineral salt is higher than that of industrially produced calcium phosphate, and the filtrate can produce a precipitate, indicating that when the same amount of selected amino acids is added, milk mineral salt is easier to ionize calcium ions than industrially produced calcium phosphate, and the ionized calcium ions can produce precipitates after a period of time, thereby achieving the effect of remineralization.

[0033] The mechanism of calcium ion generation by milk mineral salts and subsequent self-mineralization during the brushing process is as follows: ; As shown above, due to the strong polarity of the carboxyl group -COOH and the amino group -NH2 (as well as the hydroxyl group, sulfur atom or amide bond) of the amino acid, in the toothpaste and in the initial stage of brushing, the calcium ions in the milk mineral salt are ionized and form a stable chelate with the amino acid (the R-group in the above reaction formula and the schematic structure below represents a carbon chain containing a hydroxyl group or an oxygen, sulfur, nitrogen, amide, or carboxylic acid group): ; When toothpaste is first put into the mouth, the pH value of saliva in the mouth is often relatively low (usually between 4.5-55), and the above chelate is formed faster; but as brushing continues, the pH value in the mouth rises, the reversible reaction is destroyed, and the chelate reacts with OH. - The more stable hydroxyapatite is adsorbed, crystallized and precipitated on the damaged parts of the tooth surface (according to the electrochemical principle, the newly damaged parts are often the most active), and self-mineralization occurs.

[0034] Example 2 A toothpaste contains 40.00 parts of sorbitol, 11.00 parts of glycerol, 0.30 parts of sodium carboxymethyl cellulose, 0.60 parts of xanthan gum, 28.00 parts of silicon dioxide, 1.00 parts of sodium lauryl sulfate, 0.63 parts of soluble phosphate (trisodium phosphate), 0.24 parts of sodium saccharin, 1.20 parts of flavor, 3.00 parts of modified milk mineral salt (the mass ratio of cysteine ​​to milk mineral salt is 1:3), 0.40 parts of sodium benzoate, and deionized water is added to 100 parts. The pretreatment and demineralization steps of the hydroxyapatite ceramic slices used in the toothpaste-simulated tooth mineralization experiment are as follows: Prepare a 1% lactic acid solution by calculating the mass fraction: mix lactic acid and purified water, totaling 500 g; Suspend hydroxyapatite ceramic pieces of uniform specifications in 1% lactic acid solution, place the container in an oscillator, and oscillate and soak the hydroxyapatite ceramic pieces for 30 minutes; After taking out, the hydroxyapatite ceramic piece is rinsed with pure water until it becomes neutral, and air-dried to obtain the pretreated (demineralized) hydroxyapatite ceramic piece.

[0035] The surface morphology of the pretreated hydroxyapatite ceramic sheet was observed by the Analytical Testing Center of Sun Yat-sen University using a scanning electron microscope (test conditions: detector: ETD detector; resolution: 2.0 μm). Figure 1 .

[0036] SEM result analysis: Figure 1 It can be seen that the surface of hydroxyapatite after artificial demineralization is uneven, with many pits and a large number of irregular and sharp crystals. The connection area between the crystals is small and it is easy to break under stress. The macroscopic manifestation is low hardness and rough touch.

[0037] The steps of toothpaste simulation remineralization are as follows: 20 g of the toothpaste prepared in this example was placed in a container, 80 g of water was added, and the mixture was stirred to dissolve the toothpaste in the water to obtain a toothpaste mixed solution; The pretreated hydroxyapatite ceramic sheet was suspended in the toothpaste mixed solution, and then placed in an oscillator and shaken and soaked for 5 minutes; Take out the hydroxyapatite ceramic piece, rinse it with pure water, and soak it in artificial saliva; The composition of the artificial saliva used in the experiment: gastric mucin: 0.220%, sodium chloride: 0.038%, calcium chloride: 0.010g, potassium dihydrogen phosphate: 0.074%, potassium chloride: 0.111%, deionized water: the balance.

[0038] Repeat the above three steps 10 times a day for a total of 12 days. Prepare a new toothpaste solution each time and change the artificial saliva every day. Allow the hydroxyapatite ceramic sheet to dry naturally to obtain the hydroxyapatite ceramic sheet after the experiment; The hydroxyapatite ceramic piece after the experiment was observed using a scanning electron microscope (Analysis and Testing Center of Sun Yat-sen University) ( Figure 2 ).

[0039] SEM result analysis: compared with the surface morphology of the pretreated hydroxyapatite ceramic sheet, Figure 1 and Figure 2 , Figure 2 The surface is smoother, with fewer pits, the original sharp crystals have disappeared, the crystals are blocky, and the area of ​​the connected parts has increased, which shows that after the demineralized hydroxyapatite surface is mineralized by the toothpaste of Example 2, the damaged parts are repaired and the acid corrosion resistance is improved.

[0040] Example 3 A toothpaste contains 40.00 parts of sorbitol, 11.00 parts of glycerol, 0.30 parts of sodium carboxymethyl cellulose, 0.60 parts of xanthan gum, 25.00 parts of silicon dioxide, 1.00 parts of sodium lauryl sulfate, 0.90 parts of soluble phosphate (trisodium phosphate), 0.24 parts of sodium saccharin, 1.20 parts of flavor, 5.00 parts of modified milk mineral salt (the mass ratio of cysteine ​​to milk mineral salt is 1:3), 0.40 parts of sodium benzoate, and deionized water is added to 100 parts.

[0041] The simulated remineralization steps are the same as in Example 2.

[0042] The samples were sent to the Analysis and Testing Center of Sun Yat-sen University for observation under a scanning electron microscope. Figure 3 ).

[0043] SEM result analysis: compared with the surface morphology of the pretreated hydroxyapatite ceramic sheet, Figure 1 and Figure 3 , Figure 3 The surface is relatively flat with fewer pits. The originally sharp crystals have disappeared, and the crystals are block-shaped. The area of ​​the connected parts has increased, which shows that after the demineralized hydroxyapatite surface is mineralized with the toothpaste of Example 3, the damaged parts are repaired and the acid corrosion resistance is improved.

[0044] The surface morphology of the hydroxyapatite ceramic sheet after mineralization with the toothpaste of Example 2 was compared. Figure 2 and Figure 3 , Figure 3 The surface is smoother, with fewer pits, the crystals are blocky, larger in size, and have a larger area of ​​connection, which shows that when the demineralized hydroxyapatite surface is mineralized with toothpaste containing modified milk mineral salt, the content of modified milk mineral salt in the toothpaste is positively correlated with the mineralization effect. Vickers microhardness test analysis: The pre-treated (demineralized) HAP ceramic sheet and the HAP ceramic sheet treated with the toothpaste of Example 3 were used as experimental samples. Twelve locations were randomly selected and the surface was tested for Vickers microhardness at the Shanghai Jiao Tong University Testing Center. The experimental results are shown in Table 3: Table 3: Vickers microhardness test data and statistical analysis of three groups of experimental samples

[0045] Note: Group B in the table is the result of 6-day treatment with toothpaste in Example 3, and Group C is the result of 12-day treatment with toothpaste in Example 3. Compared with Group A, the t(B) value is 8.37, and P(B) < 0.01 is obtained by looking up the t distribution limit table; compared with Group A, the t(C) value is 20.63, and P(C) < 0.01 is obtained by looking up the t distribution limit table.

[0046] The results in Table 3 show that P(B) < 0.01, P(C) < 0.01, and there are very significant differences in statistics. This shows that after using the product of the present invention, the Vickers microhardness of the pretreated HAP ceramic sheet increases very significantly. The average value of the Vickers microhardness of group C (simulated mineralization for 12 days) is higher than the average value of the Vickers microhardness of group B (simulated mineralization for 6 days), which also shows that the mineralization effect is positively correlated with the use time.

[0047] Example 4 A toothpaste contains 40.00 parts of sorbitol, 11.00 parts of glycerol, 0.30 parts of sodium carboxymethyl cellulose, 0.60 parts of xanthan gum, 20.00 parts of silicon dioxide, 1.00 parts of sodium lauryl sulfate, 1.80 parts of soluble phosphate (trisodium phosphate), 0.24 parts of sodium saccharin, 1.20 parts of flavor, 10.00 parts of modified milk mineral salt (the mass ratio of cysteine ​​to milk mineral salt is 1:3), 0.40 parts of sodium benzoate, and the balance is added to 100 parts with deionized water.

[0048] The simulated remineralization steps were the same as those in Example 2 (simulated mineralization was continued for 12 days).

[0049] The hydroxyapatite ceramics after the experiment were observed using a scanning electron microscope ( Figure 4 ).

[0050] SEM result analysis: compared with the surface morphology of the pretreated hydroxyapatite ceramic sheet, Figure 1 and Figure 4 , Figure 4 The surface is smooth with almost no pits, and the original sharp crystals have completely disappeared, indicating that after the demineralized hydroxyapatite surface is mineralized using the toothpaste of Example 4, the damaged parts are repaired and the acid corrosion resistance is improved.

[0051] contrast Figure 2 , Figure 3 , Figure 4 , it can be found that the surface mineralization effect is ranked as follows Figure 4 > Figure 3 > Figure 2 , which shows that when the demineralized hydroxyapatite surface is mineralized with toothpaste containing modified milk mineral salt, the content of modified milk mineral salt in the toothpaste is positively correlated with the mineralization effect.

[0052] Comparative Example (Using dilute hydrochloric acid to help increase the release of calcium phosphate ions from milk mineral salts) A toothpaste contains 40.00 parts of sorbitol, 11.00 parts of glycerol, 0.30 parts of sodium carboxymethyl cellulose, 0.60 parts of xanthan gum, 25.00 parts of silicon dioxide, 1.00 parts of sodium lauryl sulfate, 1.22 parts of soluble phosphate (trisodium phosphate), 0.24 parts of sodium saccharin, 1.20 parts of flavor, 5.00 parts of milk mineral salt, 0.40 parts of sodium benzoate, 2.5 parts of dilute hydrochloric acid (0.5 mol / L) (added in step S2 of the toothpaste preparation method), and the remainder is added to 100 parts with deionized water.

[0053] The simulated remineralization steps were the same as those in Example 2 (simulated mineralization was continued for 12 days).

[0054] The hydroxyapatite ceramics after the experiment were observed using a scanning electron microscope ( Figure 5 ).

[0055] SEM result analysis: Figure 5 Compared with the surface morphology of the pretreated hydroxyapatite ceramic sheet ( Figure 1 ), the surfaces of hydroxyapatite in the two figures are very uneven, with many deep pits and a large number of irregular and sharp crystals, which shows that there is no change on the surface of hydroxyapatite after demineralization after the simulated mineralization experiment using the comparative toothpaste, and the comparative toothpaste has no remineralization effect. It also shows that although the addition of dilute hydrochloric acid can promote the ionization of milk mineral salts to a certain extent, it cannot make the milk mineral salts have the effect of promoting remineralization. Similarly, our experiments with nitric acid, dilute phosphoric acid, citric acid and some other chelating agents have also yielded similar results.

[0056] Combined with the above analysis, it can be considered that after using the improved milk mineral salt and toothpaste of the present invention, the surface of the pretreated HAP ceramic sheet becomes denser, smoother, the pits are reduced or shallower, the crystallization is enlarged, and the Vickers microhardness increases. Therefore, it is proved that after the demineralized hydroxyapatite surface is mineralized by applying this toothpaste, the damaged parts are repaired and the acid corrosion resistance is improved. The product of the present invention is an effective care product.

[0057] The above embodiments are preferred implementation modes of the present invention, but the implementation modes of the present invention are not limited to the above embodiments. Any other changes, modifications, substitutions, combinations, and simplifications that do not deviate from the spirit and principles of the present invention should be equivalent replacement methods and are included in the protection scope of the present invention.

Claims

1. A modified milk mineral salt, characterized in that It includes milk mineral salt and amino acid; wherein the mass ratio of amino acid to milk mineral salt is 1:19~2:1; The amino acid is one or more of arginine, glutamic acid, cystine, cysteine, aspartic acid, asparagine, methionine, threonine and serine.

2. The improved milk mineral salt according to claim 1, characterized in that: The mass ratio of the amino acid to the milk mineral salt is 1:2 to 2:

1.

3. Use of the modified milk mineral salt according to claim 1 or 2 in oral care products.

4. The use according to claim 3, characterized in that: The oral care products include toothpaste, chewing granules, chewing gum, tooth tablets, tooth powder, mouthwash, and oral spray.

5. A toothpaste, characterized in that Includes the following ingredients: Friction agent: 0~60.0% Fragrance: 0.001~2.0% Moisturizer: 0~80.0% Sweetener: 0.01~5.0% Surfactant: 0.01~4.0% Preservatives: 0~0.8% Thickener: 0.05~10.0% Soluble phosphate: 0.02~1.0% Improved milk mineral salt according to claim 1 or 2: 0.1-50.0% Food coloring: appropriate amount Deionized water: Balance.

6. The toothpaste according to claim 5, characterized in that: The friction agent includes one or more of silicon dioxide, hydrated silica, calcium hydrogen phosphate, calcium phosphate, calcium carbonate, microcrystalline cellulose, calcium pyrophosphate, aluminum hydroxide, aluminum oxide, magnesium carbonate, magnesium phosphate, zeolite powder, hydroxyapatite, ceramic powder, and nut shell powder; The humectant is selected from one or more of sorbitol, ethylene glycol, polyethylene glycol, glycerol, propylene glycol, butylene glycol, xylitol, pentylene glycol, hexylene glycol, 1,2-hexanediol, polypropylene glycol, mannose or mannitol, isomannide, maltose or maltitol, erythrose or erythritol, and sodium phytate; The sweetener includes one or more of sucralose, saccharin sodium, stevioside, potassium glycyrrhizinate, perilla sugar, erythrose, acesulfame potassium, and aspartame.

7. The toothpaste according to claim 5, characterized in that: The surfactant includes one or more of anionic surfactants, cationic surfactants, nonionic surfactants and zwitterionic surfactants; The preservative is selected from one or more of benzyl alcohol, sodium benzoate, potassium sorbate, p-hydroxybenzoate, sodium diacetate, propylparaben and its salts, p-hydroxyacetophenone, hexylene glycol, triclosan, DMDM ​​hydantoin, o-cymene-5-ol, notoginseng extract, grapefruit extract, aloe extract, honeysuckle extract, wild chrysanthemum extract, scutellaria baicalensis extract, gallnut extract, Imperata root extract, Angelica dahurica extract, pine needle extract, tea polyphenols, paeonol, and cationic bactericides.

8. The toothpaste according to claim 5, characterized in that: The thickener is selected from one or more of carrageenan, xanthan gum, xanthan gum, cellulose gum, methylcellulose, sodium carboxymethyl cellulose, ethyl cellulose, cellulose acetate, sodium ethyl cellulose, sodium alginate, arabic resin, locust bean gum, guar gum, modified guar gum, gellan gum, gelatin, cassia seed gum, tamarind seed gum, aloe vera gel, polyvinyl alcohol, sodium polyacrylate, carboxyvinyl polymer, carbomer resin, silica gel, thickening silicon dioxide, lithium magnesium silicate, magnesium aluminum silicate, gum, and arabic gum; The soluble phosphate is selected from monophosphate or polyphosphate.

9. The method for preparing a toothpaste according to any one of claims 5 to 8, characterized in that The following steps are involved: S1: placing a thickener and a moisturizer in a paste-making pot and stirring to obtain a first material; S2: placing a sweetener, a preservative and an appropriate amount of water in a premixing pot and stirring to obtain a second material; S3: placing the second material into the first material and stirring to obtain a third material; S4: adding abrasive and improved milk mineral salt to the third material and stirring to obtain a fourth material; S5: placing the remaining water and soluble phosphate in a premixing pot and stirring to obtain a fifth material; S6: placing the fifth material into the fourth material and stirring to obtain a sixth material; S7: placing a surfactant in the sixth material and stirring to obtain a seventh material; S8. Place essence and an appropriate amount of food coloring into the seventh material, stir and homogenize for 15 to 30 minutes under a vacuum environment to obtain toothpaste.

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