Preservative-free cleaning composition

Abstract

The present invention discloses a preservative-free cleaning composition comprising: 20 to 70 wt% of an amphoteric surfactant, the amphoteric surfactant being a combination of an amphoteric acetate-based surfactant and a betaine-based surfactant; 5 to 25% by weight of 1, 3-butanediol; and a carrier acceptable in the personal care field. The invention provides an antiseptic-free cleaning system compounded by 1, 3-butanediol and an ampholytic surfactant, and can solve the problems of poor antiseptic effect, high antiseptic cost, limited antiseptic selection and the like of a cleaning system product.

Description

Technical Field

[0001] The present invention relates to a cleaning composition, in particular to a cleaning composition based on 1,3-butylene glycol and an amphoteric surfactant. The cleaning composition can pass the three-level preservative challenge without using cosmetic approved preservatives and various mild preservative systems on the market, thus achieving a truly preservative-free dosage form in a groundbreaking manner. Background Art

[0002] The role of preservatives in cosmetics is mainly to inhibit the growth and reproduction of microorganisms, maintain the stability of the properties of cosmetics, prevent them from deteriorating after opening and use, and extend the shelf life. Cosmetics with more water content, such as lotions and cleaning products, have a greater demand for preservatives; while the closer the cosmetics are to ointments or waxes, the more difficult it is for microorganisms to survive, and the demand for preservatives is relatively small. In the production of cosmetics, several preservatives are usually used in combination to achieve the effects of expanding the antibacterial range, improving efficacy, and resisting secondary pollution. Cosmetic preservatives refer to substances added to cosmetics for the purpose of inhibiting the growth and reproduction of microorganisms in cosmetics.

[0003] Preservatives themselves do not contribute to the efficacy of cosmetics, but while inhibiting the reproduction of microorganisms (bacteria, fungi, and molds), they may have some negative effects on cosmetics: for example, irritating the user's skin (especially sensitive skin), causing sensitivity, damaging the effectiveness of certain active ingredients in the formula, affecting the stability of the formula, etc. Out of consideration for product safety, additive-free cosmetics that are mainly free of preservatives, fragrances, and pigments are gradually becoming popular.

[0004] In addition, because cleaning personal care products contain high levels of surfactant ingredients, they have a certain volume expansion or micellar encapsulation effect on various preservatives, which reduces the effect of preservatives to a certain extent. Therefore, the formula design of conventional personal care cleaning products usually uses a large dose of preservatives to ensure the preservative effect, and even chooses to use paraben preservatives or preservatives containing formaldehyde releasers. Therefore, the design of preservative-free cleaning compositions in personal care cleaning products has become a major technical barrier in the industry. Many experts have begun to use mild preservatives or antibacterial ingredients outside the catalog of permitted preservatives for cosmetics for preservation in their research, and thus began to make "preservative-free" claims. However, this type of mild preservative ingredient outside the catalog of permitted preservatives for cosmetics is first of all relatively expensive, which brings a great burden to the ingredients of product development, especially for cleaning products with lower prices. In addition, because cleaning products use a lot of transparent packaging, this type of mild preservative ingredient has a very serious discoloration, which seriously affects the appearance of the material. In addition, because the mild preservative ingredients outside the list of approved preservatives for this type of cosmetics have weaker preservative properties and require higher amounts to be added, they will have a significant impact on the entire cleaning formula system, causing surfactant stratification, reduced system viscosity, etc.

[0005] Chinese patent application CN201710332913.7 discloses a plant-extracted preservative-free ginger silicone-free shampoo and a preparation method thereof, and provides a plant-extracted preservative-free ginger silicone-free shampoo, comprising the following raw materials in weight percentage: 0.1-5% gingerol and 0.4-6% fat excipient; the fat excipient is a mixture of PPG-3 octyl ether, 12-13 carbon alcohol lactate, PEG-55 propylene glycol oleate and PEG-7 glyceryl cocoate. The present invention also provides a preparation method for plant-extracted preservative-free ginger silicone-free shampoo. The shampoo of the present invention can effectively clean and nourish the hair and scalp, strengthen the hair roots, make the hair refreshing, elegant and smooth, and will not cause the scalp to be difficult to breathe after shampooing, and will not be greasy and heavy. At the same time, it can increase the luster of the hair, giving people a relaxed and comfortable feeling. The preservatives in the plant-based ginger and silicone-free shampoo are a mixture of caprylhydroxamic acid, parahydroxyacetophenone, glyceryl caprylate and butylene glycol.

[0006] Chinese patent application CN201711210561.4 discloses a non-preservative deep moisturizing skin care product, which mainly relates to a non-preservative deep moisturizing skin care product, wherein the raw materials for preparing the skin care product include a moisturizer and a skin conditioner; the moisturizer includes a saccharide isomer and sodium hyaluronate; and the skin conditioner includes hydrolyzed silk protein. The skin care product of the present invention combines the saccharide isomers, hydrolyzed silk protein and sodium hyaluronate for internal and external skin moisturizing and conditioning. The internal conditioning of hydrolyzed silk protein and sodium hyaluronate can not only penetrate into the lipid layer of the skin follicles to replenish the protein moisture lost by the skin, but also enhance the elasticity of the skin and make the skin soft and smooth. The external saccharide isomers are used to lock the outflowing moisture, so that the skin is long-lasting and tender, and deeply moisturizes and moisturizes. In this way, the moisturizer and the skin conditioner are compounded, and the internal and external phases are combined, which not only keeps the inner layer of the skin moisturized for a long time, but also prevents the loss of moisture on the surface and delays aging. The preservative-free deep hydrating skin care product has a mixture of 1,2-hexanediol, propylene glycol and caprylhydroxamic acid as a preservative alternative.

[0007] Chinese patent application CN201910232147.6 discloses a method for preparing a mild moisturizing cream without preservative addition. The present invention provides a method for preparing a mild moisturizing cream without preservative addition, using oil phase and water phase as raw materials, sodium hydroxide and purslane extract to prepare a mild moisturizing cream without preservative addition. It has excellent biodegradability and the characteristics of being natural, mild and safe, suitable for all types of skin, and has excellent emulsification ability. Its emulsification system is stable, has liquid crystal characteristics, can produce a crystal clear paste, and feels soft and moisturizing. The method for preparing a mild moisturizing cream without preservative addition, the preservatives are 0.1-0.3 mol / L of glyceryl caprylate and 0.1-0.3 mol / L of caprylhydroxamic acid.

[0008] In response to the technical barriers to mild preservation in personal care cleaning products mentioned above, the present invention unexpectedly discovered that combining amphoteric surfactants with polyols (such as 1,3-butanediol) can solve the problems of poor preservative effect of cleaning system products, high preservative costs, and limited preservative selection, thereby achieving truly preservative-free cosmetics. Summary of the invention

[0009] In one aspect, the present invention provides a preservative-free cleaning composition comprising:

[0010] 20-70% by weight of an amphoteric surfactant, wherein the amphoteric surfactant is a combination of an amphoteric acetate surfactant and a betaine surfactant;

[0011] 5-25 wt% 1,3-butanediol; and

[0012] A personal care acceptable carrier.

[0013] In a preferred embodiment, the composition of the present invention comprises 30-60% by weight of an amphoteric surfactant. In a preferred embodiment, the amphoteric acetate surfactant is sodium cocoylamphoacetate, and the betaine surfactant is cocamidopropyl betaine. In a preferred embodiment, the weight ratio of the amphoteric acetate surfactant to the betaine surfactant is 2:3 to 3:2.

[0014] In a preferred embodiment, the composition of the present invention further comprises an anionic surfactant, and the anionic surfactant is AES. In a preferred embodiment, the composition comprises 1-10 wt% of anionic surfactant.

[0015] In a preferred embodiment, the composition of the present invention comprises 5 to 20% by weight of 1,3-butanediol.

[0016] In a preferred embodiment, the pH value of the composition of the present invention is 7-10.

[0017] In another aspect, the present invention also relates to the use of the preservative-free cleaning composition in personal care products.

[0018] In a preferred embodiment, the personal care product is selected from the group consisting of: baby shower gel, baby shampoo, baby shampoo and body wash, children's hand soap, adult shower gel, adult shampoo, adult hand soap and adult facial cleanser. DETAILED DESCRIPTION

[0019] Unless otherwise defined, all technical and scientific terms used herein have the same meanings as commonly understood by those of ordinary skill in the art to which the invention belongs. Although any methods and materials similar or equivalent to those described herein can be used to implement or test the present invention, preferred methods and materials are described herein. For purposes of the present invention, the following terms are defined below.

[0020] As used herein, the term "about" refers to an amount, level, value, dimension, size, or amount that differs by up to 30%, 20%, or 10% compared to the amount, level, value, dimension, size, or amount of a reference product. Percentages used herein, unless otherwise indicated, are by weight.

[0021] Throughout the specification and claims, unless otherwise required, the following words "comprise" and variations "comprising" and "including" will be understood to imply the inclusion of a stated integer or step, or a group of integers or steps, but not the exclusion of any other integer or step, or other group of integers or steps.

[0022] As used herein, the term "cleansing composition" (or alternatively "cleanser") refers to a flowable composition that can be used to clean dirt and / or oil from the user's skin or hair. The cleaning composition is intended to be applied to the user's skin and / or hair for a limited period of time and then removed by washing or wiping with a wipe or other implement.

[0023] All percentages of components herein are in weight percent. In some respects, the percentage is the weight percent of the final cleaning composition, and in some respects, the weight percent is the weight percent of the specific system described. For example, the final cleaning composition advantageously comprises a surfactant system that is a blend of multiple surfactants. As described in the specification, the amount of these surfactants can be described as the weight percent of the final cleaning composition or alternatively the weight percent of the surfactant system. If a component is described herein as being present in a specific weight percent without further identifiers, the expected weight percent is relative to the final cleaning composition.

[0024] As used herein, the term "consisting essentially of means that the composition contains less than about 1%, preferably less than about 0.5%, of ingredients other than those listed.

[0025] In addition, the terms "substantially free," "substantially free," or "substantially free" mean that the specified material is present in an amount of 0 wt % to about 0.5 wt %, or preferably 0 wt % to about 0.1 wt %, or more preferably 0 wt % to about 0.01 wt %, and most preferably it is not present in an analytically detectable amount. The terms "substantially pure" or "substantially pure" mean that the specified material is present in an amount of about 99.5 wt % to about 100 wt %, preferably about 99.9 wt % to about 100 wt %, and more preferably 99.99 wt % to about 100 wt %, and most preferably all other materials are present only as impurities below an analytically detectable amount.

[0026] The present invention aims at the technical barriers of mild preservation in personal care and cleaning products, utilizes the special pH value and certain antibacterial characteristics of amphoteric surfactants, and studies their antiseptic properties in combination with different polyols. Finally, innovatively researches out a cleaning composition prepared by combining amphoteric surfactants with a certain proportion of 1,3-butanediol, thus realizing truly preservative-free cosmetics and breaking through the technical barriers of mild preservation in personal care and cleaning products.

[0027] The present invention relates to a cleaning composition prepared based on 1,3-butanediol and an amphoteric surfactant. The cleaning composition can pass the three-level preservative challenge by using only 1,3-butanediol and an amphoteric surfactant without using any cosmetic approved preservatives and various mild preservative systems on the market, thereby ensuring its preservative performance and realizing a truly preservative-free formulation in a pioneering manner.

[0028] The cleaning composition of the present invention does not contain additional preservatives. Moreover, the preservative-free cleaning composition of the present invention has a transparent appearance, a stable system, rich and dense foam, and a good use experience. The cleaning composition can be used in personal bath products, facial cleansing products, and pet bath products, and can be packaged using a foam pump to create a foam-type cleaning product.

[0029] Amphoteric surfactant

[0030] Amphoteric surfactants are surfactants that have two ionic properties at the same time.

[0031] In certain embodiments, the compositions of the present invention comprise about 20-70% by weight of an amphoteric surfactant. In a preferred embodiment, the compositions of the present invention comprise 30-60% by weight of an amphoteric surfactant.

[0032] In certain embodiments of the present invention, the amphoteric surfactant is selected from the group consisting of: amphoteric acetate surfactants, betaine surfactants, and combinations thereof.

[0033] In some embodiments, the amphoacetate surfactant is sodium lauroamphoacetate, sodium cocoamphoacetate, or a combination thereof.

[0034] In certain embodiments, the compositions of the present invention comprise about 5-40% by weight of an amphoteric acid salt surfactant. In a preferred embodiment, the compositions of the present invention comprise 5-30% by weight of an amphoteric acid salt surfactant. In a preferred embodiment, the compositions of the present invention comprise 10-30% by weight of an amphoteric acid salt surfactant. In a more preferred embodiment, the compositions of the present invention comprise 20-30% by weight of an amphoteric acid salt surfactant.

[0035] In some embodiments, the active content of the amphoacetate surfactant is 30%.

[0036] In a specific embodiment, the present invention uses sodium cocoamphoacetate purchased from Solvay Fine Chemicals Co., Ltd. under the trade name MiranolL ULTRA C 32.

[0037] In some embodiments, the betaine-based surfactant is cocamidopropyl betaine, lauryl hydroxysultaine, or a combination thereof.

[0038] In certain embodiments, the compositions of the present invention comprise about 5-40% by weight of a betaine surfactant. In a preferred embodiment, the compositions of the present invention comprise 5-30% by weight of a betaine surfactant. In a preferred embodiment, the compositions of the present invention comprise 10-30% by weight of a betaine surfactant. In a more preferred embodiment, the compositions of the present invention comprise 20-30% by weight of a betaine surfactant.

[0039] In some embodiments, the active content of the betaine surfactant is 30%.

[0040] In a specific embodiment, the present invention uses cocamidopropyl hydroxysulfobetaine purchased from Guangzhou Xingye Technology Co., Ltd. under the trade name Ucefactant CSB (L).

[0041] In some embodiments, the amphoteric surfactant is a combination of an amphoteric acetate surfactant and a betaine surfactant, wherein the weight ratio of the amphoteric acetate surfactant to the betaine surfactant is 2:3 to 3:2. In a preferred embodiment, the weight ratio of the amphoteric acetate surfactant to the betaine surfactant is 1:1.

[0042] Polyols

[0043] The cleaning compositions of the present invention may comprise from about 1 to 50% by weight, preferably from about 5 to 50% by weight, more preferably from 10 to 30% by weight of one or more polyols.

[0044] The polyols useful herein include, for example, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, or a combination thereof.

[0045] In some embodiments, the cleaning compositions of the present invention comprise 5-30% by weight of a polyol. In a preferred embodiment, the cleaning compositions of the present invention comprise 5-25% by weight of a polyol. In a preferred embodiment, the cleaning compositions of the present invention comprise 5-20% by weight of a polyol. In a specific embodiment, the cleaning compositions of the present invention comprise 5-15% by weight of a polyol.

[0046] Preferably, the cleaning composition of the present invention comprises 1,3-butanediol. In some embodiments, the cleaning composition of the present invention comprises 10% by weight of 1,3-butanediol.

[0047] pH of the cleaning composition

[0048] The measured pH value of the cleaning composition of the present invention is about 7-10. In a more preferred embodiment, the pH of the cleaning composition is about 8-10. Preferably, the pH of the cleaning composition of the present invention is 8-9.

[0049] Due to the specific formula of the present invention, the pH of the final cleaning composition will not be too alkaline, thereby providing a preservative-free liquid cleaning composition with transparent appearance, stable system, rich and dense foam and good use experience.

[0050] Other components

[0051] The composition may comprise water or other aqueous carrier in an amount from about 10% to about 80% by weight of the final composition, or from about 20% to about 75% by weight of the final composition.

[0052] The composition may further comprise an anionic surfactant. In a preferred embodiment, the anionic surfactant is AES. Preferably, the composition comprises 1-10 wt % of anionic surfactant. Preferably, the composition comprises 5-10 wt % of anionic surfactant.

[0053] In some embodiments, the anionic surfactant is an alkyl ethoxylated sulfate. In a preferred embodiment, the anionic surfactant is a laureth sulfate salt, preferably sodium laureth sulfate.

[0054] In a specific embodiment, the composition of the present invention uses AES with the trade name Texapon N 70 purchased from BASF New Materials Co., Ltd.

[0055] It is desirable to include one or more chelating agents, such as disodium ethylenediaminetetraacetic acid (EDTA). Other chelating agents that can be used in the composition include, for example, tetrasodium ethylenediaminetetraacetic acid (EDTA) and tetrasodium glutamate diacetate. The chelating agent can be used in an amount of about 0.001% to about 0.25% by weight of the final composition or about 0.001% to about 0.5% by weight of the final composition. Preferably, the chelating agent is used in an amount of 0.05-0.3% by weight. In a specific embodiment, the chelating agent is used in an amount of 0.2% by weight.

[0056] Some compositions may contain optional components such as fragrances, colorants, and other aesthetic components. If used, fragrances and colorants may be present in a combined amount of about 0.01% to about 6% by weight of the composition. Colorants may be less desirable for achieving a completely transparent composition, but may be included provided that the final composition meets the clarity requirements.

[0057] The composition of the present invention may also include a thickener. Thickeners that can be used in the present invention include polyethylene glycols, such as PEG-150 distearate, which is a polyethylene glycol diester of stearic acid, sometimes referred to as polyethylene glycol 6000 distearate or polyoxyethylene (150) distearate. Other polyethylene glycols include, for example, PEG-120 methyl glucose dioleate, PEG-18 oleic acid glyceryl / cocoate glyceryl, PEG-55 propylene glycol oleate, PEG-200 hydrogenated palm glyceryl; and PEG-7 cocoate glyceryl. Thickeners can be included in any desired amount so that they provide the desired viscosity level, but keep in mind that the above-mentioned transparency and mildness levels should still be achieved. Thickeners can be used in an amount of about 0.01% to about 4% by weight of the final composition or alternatively about 0.01% to about 1.5% by weight of the final composition.

[0058] Preservative-free cleaning compositions

[0059] The cleaning compositions of the present invention are substantially free of preservatives.

[0060] The cleaning composition of the present invention is prepared by the following method:

[0061] (a) mixing an amphoteric surfactant, an optional anionic surfactant, an optional chelating agent and a portion of water,

[0062] (b) adding 1,3-butanediol,

[0063] (c) adding an optional polyol,

[0064] (d) Adjust the pH to 8-9 and make up to 100% with water.

[0065] In some embodiments, the step (a) is performed under stirring at 80-85°C.

[0066] In some embodiments, the step (b) is performed under stirring at 50-55°C.

[0067] In some embodiments, the above step (c) is performed under stirring conditions at 40-45°C.

[0068] In some embodiments, after the above step (d), stirring is continued and the mixture is cooled to room temperature to obtain the desired cleaning composition.

[0069] In some embodiments, the stirring condition comprises stirring at a rotation speed of 100 rpm.

[0070] In certain embodiments, the total concentration of surfactants in the present composition is equal to or greater than 18% by weight. In a preferred embodiment, the total concentration of surfactants in the present composition is 18-60% by weight. In a preferred embodiment, the total concentration of surfactants in the present composition is 18-50% by weight. In a preferred embodiment, the total concentration of surfactants in the present composition is 18-30% by weight. In a preferred embodiment, the total concentration of surfactants in the present composition is 18-25% by weight.

[0071] In some embodiments, the composition of the present invention further comprises an inorganic base and / or an inorganic acid.

[0072] In some embodiments, the compositions of the present invention comprise about 0.1-2 wt % of an inorganic base. In a preferred embodiment, the compositions of the present invention comprise 0.1-1 wt % of an inorganic base.

[0073] In some embodiments, the compositions of the present invention comprise about 0.1-2 wt% of an inorganic acid. In a preferred embodiment, the compositions of the present invention comprise 0.1-1 wt% of an inorganic acid.

[0074] Package

[0075] The cleaning compositions described herein may be contained in any type of desired packaging, including, for example, pump packs, squeeze bottles, or tubes, etc. It may be desirable for the packaging to be transparent or translucent so that the user can view the transparency of the composition upon purchase.

[0076] How to use

[0077] The product can be applied to the user's skin or hair in any desired manner. In some aspects, the product can be applied directly by hand, or a device such as a towel, sponge or other device can be used to apply the product. The composition is advantageously applied to wet hair or skin to facilitate application. The composition can be left on the area of ​​application for a desired level of time, such as from about 5 seconds to about 5 minutes, and then washed with water to remove from the area of ​​application.

[0078] Example

[0079] The present invention will be further described below in conjunction with specific examples. However, it should be understood that these examples are only used to illustrate the present invention and do not constitute a limitation of the scope of the present invention. The test methods in the following examples that do not specify specific conditions are usually based on conventional conditions or the conditions recommended by the manufacturer. Unless otherwise stated, all percentages and parts are by weight.

[0080] The experimental materials used in the embodiment are as follows:

[0081] AES, trade name Texapon N 70, purchased from BASF New Materials Co., Ltd.;

[0082] Cocamidopropyl betaine, trade name MIRATAINE CAB, purchased from Solvay Fine Chemicals Co., Ltd.;

[0083] Sodium cocoamphoacetate, trade name MiranolL ULTRA C 32, purchased from Solvay Fine Chemicals Co., Ltd.;

[0084] EDTA-2NA, trade name Dissolvine Na2, purchased from Nouryon Chemicals (Ningbo) Co., Ltd.;

[0085] 1,3-Butylene Glycol, trade name 1,3-Butylene Glycol, purchased from DAICEL CORPORATION;

[0086] 1,2-Hexanediol, trade name SHD62, purchased from SHINSUNG MATERIAL CO., LTD.;

[0087] Citric acid, trade name citric acid monohydrate, purchased from Shandong Yingxuan Industrial Co., Ltd.;

[0088] Potassium hydroxide, trade name potassium hydroxide LM type II, was purchased from Uni-T (Jiangsu) Chemical Co., Ltd.

[0089] Example 1: Preparation of preservative-free cleaning composition

[0090] Weigh 10 parts by mass of AES, add 30 parts by mass of cocamidopropyl betaine and 30 parts by mass of sodium cocoylamphoacetate, then add 15 parts by mass of deionized water and 0.2 parts by mass of EDTA-2NA, heat to 85-80°C, mix and stir at a speed of 100 rpm until all dissolved, and the material is transparent; cool to 50-55°C, add 10 parts by mass of 1,3-butylene glycol, stir until transparent, and then defoam; cool to 40-45°C and add 2 parts by mass of hexanediol, use citric acid or potassium hydroxide to adjust the pH to 8-9, and make up the remainder to 100 with deionized water, and continue to mix and stir at a speed of 100 rpm for 15-20 minutes. Then cool the mixture to room temperature, let it stand at room temperature for 12 hours, and set aside.

[0091] Example 2: Preparation of preservative-free cleaning composition

[0092] Weigh 10 parts by mass of AES, add 30 parts by mass of cocamidopropyl betaine and 30 parts by mass of sodium cocoylamphoacetate, then add 15 parts by mass of deionized water and 0.2 parts by mass of EDTA-2NA, heat to 85-80°C and mix and stir at a speed of 100 rpm until all dissolved and the material is transparent; cool to 50-55°C, add 5 parts by mass of 1,3-butylene glycol, stir until transparent and then defoam; cool to 40-45°C and add 2 parts by mass of hexanediol, use citric acid or potassium hydroxide to adjust the pH to 8-9, and make up the remainder to 100 with deionized water, and continue to mix and stir at a speed of 100 rpm for 15-20 minutes. Then cool the mixture to room temperature, let it stand at room temperature for 12 hours, and set aside.

[0093] Example 3: Preparation of preservative-free cleaning composition

[0094] Weigh 10 parts by mass of AES, add 30 parts by mass of cocamidopropyl betaine and 30 parts by mass of sodium cocoylamphoacetate, then add 15 parts by mass of deionized water and 0.2 parts by mass of EDTA-2NA, heat to 85-80°C, mix and stir at a speed of 100 rpm until all dissolved, and the material is transparent; cool to 50-55°C, add 2 parts by mass of 1,3-butanediol, stir until transparent, and then defoam; cool to 40-45°C and add 2 parts by mass of hexanediol, use citric acid or potassium hydroxide to adjust the pH to 8-9, and make up the remainder to 100 with deionized water, and continue to mix and stir at a speed of 100 rpm for 15-20 minutes. Then cool the mixture to room temperature, let it stand at room temperature for 12 hours, and set aside.

[0095] Example 4: Preparation of preservative-free cleaning composition

[0096] Weigh 10 parts by mass of AES, add 30 parts by mass of cocamidopropyl betaine and 30 parts by mass of sodium cocoylamphoacetate, add 15 parts by mass of deionized water and 0.2 parts by mass of EDTA-2NA, heat to 85-80°C and mix and stir at a speed of 100rpm until all dissolved, and the material is transparent; cool to 40-45°C and add 2 parts by mass of hexylene glycol, use citric acid or potassium hydroxide to adjust the pH to 8-9, and make up the remainder to 100 with deionized water, and continue to mix and stir at a speed of 100rpm for 15-20 minutes. The mixture is then cooled to room temperature and left to stand at room temperature for 12 hours for standby use.

[0097] Test Example 1: Stability and Usability Test

[0098] The specific method for investigating the stability and usability of Examples 1-4 is as follows:

[0099] Stability evaluation method: The liquid cleaning compositions prepared in Examples 1-4 were placed in a thermostat at high temperature (48°C, 25°C, 4°C) for 30 days. The samples were observed to see if there were any solid particles precipitating out, jelloing, or stratification. If the sample was normal and unchanged before and after a certain time within 30 days, it was considered "passed", the presence of particles was considered "precipitation", the solidification of the material that was difficult to flow was considered "jelly", and the presence of two layers of liquid was considered "stratification".

[0100] Usability evaluation method:

[0101] The 5-member evaluation team observed and tried the product, then scored it and took the average of the five-member evaluation team. The product appearance score (material texture color) and the use experience score (foam volume and cleanliness) are evaluated. Among them, the material texture color is 0-10 points: 0-3 points are turbid material and abnormal color, 4-6 points are translucent material and normal color, 7 points-10 points are transparent material and normal color. The higher the score, the higher the transparency and the more attractive the appearance to consumers; and the use experience score (foam volume and cleanliness) is 0-10 points: 0-3 points are less foam or poor cleaning power, 4-6 points are general cleaning feeling or moderate foam, 7 points-10 points are good washing feeling, strong cleaning power or rich foam, and the higher the score, the better the use experience.

[0102] Table 1 shows the stability and usability test results of different preservative-free cleaning compositions.

[0103] Table 1

[0104]

[0105] Conclusion: The cleaning compositions of Examples 1-4 are all composed of amphoteric surfactants and anionic surfactants, and have the same active ingredient content, about 25% of active ingredients, so the usability of Examples 1-4 is maintained at an excellent level. The different amounts of 1,3-butanediol added do not affect the appearance and stability of the formula system, and the texture and color of the material are all good, and the 30-day stability has passed.

[0106] Test Example 2: Corrosion Challenge Test

[0107] Test sample: non-preservative cleaning composition prepared in Examples 1-4

[0108] Test bacteria: Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Burkholderia cepacia, Candida albicans, Paecilomyces cerevisiae, Aspergillus niger

[0109] Test bacteria concentration: 10 6 cfu / mL, mold and yeast are 10 5 cfu / mL

[0110] Specific test: 7 kinds of bacteria were mixed and inoculated once, and observed for 28 days.

[0111] The results are shown in Table 2-5.

[0112] Table 2: Preservative Challenge Results for Non-Preservative Cleaning Composition Example 1

[0113]

[0114] Table 3: Preservative Challenge Results for Non-Preservative Cleaning Composition Example 2

[0115]

[0116] Table 4 Anticorrosion Challenge Results of Non-Anticorrosive Cleaning Composition Example 3

[0117]

[0118] Table 5: Preservative Challenge Results for Non-Preservative Cleaning Composition Example 4

[0119]

[0120] Conclusion: The cleaning compositions of Examples 1-4 are all composed of amphoteric surfactants and anionic surfactants, and have the same active ingredient content, all containing about 25% active ingredients, while the addition amount of 1,3-butanediol is different, which significantly affects the antiseptic properties of the cleaning compositions. According to the results: the addition amount of 1,3-butanediol in the range of 5-10% can achieve a good antiseptic effect and pass the three-level antiseptic challenge, while the addition amount of 1,3-butanediol in the range of 0-2% does not pass the three-level antiseptic challenge.

[0121] Example 5: Preparation of preservative-free cleaning composition

[0122] Weigh 10 parts by mass of AES, add 30 parts by mass of cocamidopropyl betaine and 30 parts by mass of sodium cocoylamphoacetate, then add 15 parts by mass of deionized water and 0.2 parts by mass of EDTA-2NA, heat to 85-80°C, mix and stir at a speed of 100 rpm until all dissolved, and the material is transparent; cool to 50-55°C, add 10 parts by mass of 1,3-butylene glycol, stir until transparent, and then defoam; cool to 40-45°C and add 2 parts by mass of hexanediol, use citric acid or potassium hydroxide to adjust the pH to 8-9, and make up the remainder to 100 with deionized water, and continue to mix and stir at a speed of 100 rpm for 15-20 minutes. Then cool the mixture to room temperature, let it stand at room temperature for 12 hours, and set aside.

[0123] Example 6: Preparation of preservative-free cleaning composition

[0124] Weigh 10 parts by mass of AES, add 30 parts by mass of cocamidopropyl betaine and 30 parts by mass of sodium cocoylamphoacetate, then add 15 parts by mass of deionized water and 0.2 parts by mass of EDTA-2NA, heat to 85-80°C and mix and stir at a speed of 100 rpm until all dissolved and the material is transparent; cool to 50-55°C, add 10 parts by mass of 1,3-butylene glycol, stir until transparent and then defoam; cool to 40-45°C and add 1 part by mass of hexanediol, use citric acid or potassium hydroxide to adjust the pH to 8-9, and make up the remainder to 100 with deionized water, and continue to mix and stir at a speed of 100 rpm for 15-20 minutes. Then cool the mixture to room temperature, let it stand at room temperature for 12 hours, and set aside.

[0125] Example 7: Preparation of preservative-free cleaning composition

[0126] Weigh 10 parts by mass of AES, add 30 parts by mass of cocamidopropyl betaine and 30 parts by mass of sodium cocoylamphoacetate, then add 15 parts by mass of deionized water and 0.2 parts by mass of EDTA-2NA, heat to 85-80°C and mix and stir at a speed of 100 rpm until all dissolved and the material is transparent; cool to 50-55°C, add 10 parts by mass of 1,3-butylene glycol, stir until transparent and then defoam; cool to 40-45°C and add 0.5 parts by mass of hexanediol, use citric acid or potassium hydroxide to adjust the pH to 8-9, and make up the remainder to 100 with deionized water, and continue to mix and stir at a speed of 100 rpm for 15-20 minutes. Then cool the mixture to room temperature, let it stand at room temperature for 12 hours, and set aside.

[0127] Example 8: Preparation of preservative-free cleaning composition

[0128] Weigh 10 parts by mass of AES, add 30 parts by mass of cocamidopropyl betaine and 30 parts by mass of sodium cocoylamphoacetate, then add 15 parts by mass of deionized water and 0.2 parts by mass of EDTA-2NA, heat to 85-80°C, mix and stir at a speed of 100 rpm until all dissolved, and the material is transparent; cool to 50-55°C, add 10 parts by mass of 1,3-butylene glycol, stir until transparent, and then defoam; cool to 40-45°C, use citric acid or potassium hydroxide to adjust the pH to 8-9, and make up the remainder to 100 with deionized water, and continue to mix and stir at a speed of 100 rpm for 15-20 minutes. Then cool the mixture to room temperature, and let it stand at room temperature for 12 hours for standby use.

[0129] Test Example 3: Stability and Usability Test

[0130] The specific methods for investigating the stability and usability of Examples 5-8 are as follows:

[0131] Stability evaluation method: The liquid cleaning compositions prepared in Examples 5-8 were placed in a thermostat at a high temperature (48°C, 25°C, 4°C) for 30 days. The samples were observed to see if there were any solid particles precipitating out, jelloing, or stratification. If the sample was normal and unchanged before and after a certain time within 30 days, it was considered "passed", the presence of particles was considered "precipitation", the solidification of the material that was difficult to flow was considered "jelly", and the presence of two layers of liquid was considered "stratification".

[0132] Usability evaluation method:

[0133] The 5-member evaluation team observed and tried the product, then scored it and took the average of the five-member evaluation team. The product appearance score (material texture color) and the use experience score (foam volume and cleanliness) are evaluated. Among them, the material texture color is 0-10 points: 0-3 points are turbid material and abnormal color, 4-6 points are translucent material and normal color, 7 points-10 points are transparent material and normal color. The higher the score, the higher the transparency and the more attractive the appearance to consumers; and the use experience score (foam volume and cleanliness) is 0-10 points: 0-3 points are less foam or poor cleaning power, 4-6 points are general cleaning feeling or moderate foam, 7 points-10 points are good washing feeling, strong cleaning power or rich foam, and the higher the score, the better the use experience.

[0134] Table 6 shows the stability and usability testing of various preservative-free cleaning compositions.

[0135] Table 6

[0136]

[0137] Conclusion: The cleaning compositions of Examples 5-8 are all composed of amphoteric surfactants and anionic surfactants, and have the same active ingredient content, all containing about 25% active ingredients, so the usability of Examples 5-8 is maintained at an excellent level. The different amounts of hexylene glycol added do not affect the appearance and stability of the formula system, and the texture and color of the material are all good, and the 30-day stability has passed.

[0138] Test Example 4: Anticorrosion Challenge Test

[0139] Test sample: non-preservative cleaning composition prepared in Examples 5-8

[0140] Test bacteria: Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Burkholderia cepacia, Candida albicans, Paecilomyces cerevisiae, Aspergillus niger

[0141] Test bacteria concentration: 10 6 cfu / mL, mold and yeast are 10 5 cfu / mL

[0142] Specific test: 7 kinds of bacteria were mixed and inoculated once, and observed for 28 days.

[0143] The results are shown in Tables 7-10.

[0144] Table 7: Preservative Challenge Results for Non-Preservative Cleaning Composition Example 5

[0145]

[0146] Table 8: Preservative Challenge Results for No-Preservative Cleaning Composition Example 6

[0147]

[0148] Table 9: Preservative Challenge Results for Non-Preservative Cleaning Composition Example 7

[0149]

[0150] Table 10: Preservative Challenge Results for Non-Preservative Cleaning Composition Example 8

[0151]

[0152] Conclusion: The cleaning compositions of Examples 5-8 are all composed of amphoteric surfactants and anionic surfactants, and have the same active ingredient content, all containing about 25% active ingredients, while the different amounts of hexylene glycol added do not affect the antiseptic properties of the cleaning compositions. The results show that the addition of hexylene glycol in the range of 2-0% can achieve a good antiseptic effect and pass the three-level antiseptic challenge.

[0153] Example 9: Preparation of preservative-free cleaning composition

[0154] Weigh 10 parts by mass of AES, add 30 parts by mass of cocamidopropyl betaine and 30 parts by mass of sodium cocoylamphoacetate, then add 15 parts by mass of deionized water and 0.2 parts by mass of EDTA-2NA, heat to 85-80°C, mix and stir at a speed of 100 rpm until all dissolved, and the material is transparent; cool to 50-55°C, add 10 parts by mass of 1,3-butylene glycol, stir until transparent, and then defoam; cool to 40-45°C and add 2 parts by mass of hexanediol, use citric acid or potassium hydroxide to adjust the pH to 8-9, and make up the remainder to 100 with deionized water, and continue to mix and stir at a speed of 100 rpm for 15-20 minutes. Then cool the mixture to room temperature, let it stand at room temperature for 12 hours, and set aside.

[0155] Example 10: Preparation of preservative-free cleaning composition

[0156] Weigh 10 parts by mass of AES, add 30 parts by mass of cocamidopropyl betaine and 30 parts by mass of sodium cocoylamphoacetate, then add 15 parts by mass of deionized water and 0.1 parts by mass of EDTA-2NA, heat to 85-80°C and mix and stir at a speed of 100 rpm until all dissolved and the material is transparent; cool to 50-55°C, add 10 parts by mass of 1,3-butylene glycol, stir until transparent and then defoam; cool to 40-45°C and add 2 parts by mass of hexanediol, use citric acid or potassium hydroxide to adjust the pH to 8-9, and make up the remainder to 100 with deionized water, and continue to mix and stir at a speed of 100 rpm for 15-20 minutes. Then cool the mixture to room temperature, let it stand at room temperature for 12 hours, and set aside.

[0157] Example 11: Preparation of preservative-free cleaning composition

[0158] Weigh 10 parts by mass of AES, add 30 parts by mass of cocamidopropyl betaine and 30 parts by mass of sodium cocoylamphoacetate, then add 15 parts by mass of deionized water and 0.05 parts by mass of EDTA-2NA, heat to 85-80°C and mix and stir at a speed of 100 rpm until all dissolved and the material is transparent; cool to 50-55°C, add 10 parts by mass of 1,3-butanediol, stir until transparent and then defoam; cool to 40-45°C and add 2 parts by mass of hexanediol, use citric acid or potassium hydroxide to adjust the pH to 8-9, and make up the remainder to 100 with deionized water, and continue to mix and stir at a speed of 100 rpm for 15-20 minutes. Then cool the mixture to room temperature, let it stand at room temperature for 12 hours, and set aside.

[0159] Example 12: Preparation of preservative-free cleaning composition

[0160] Weigh 10 parts by mass of AES, add 30 parts by mass of cocamidopropyl betaine and 30 parts by mass of sodium cocoylamphoacetate, then add 15 parts by mass of deionized water, heat to 85-80°C, mix and stir at a speed of 100 rpm until all dissolved, and the material is transparent; cool to 50-55°C, add 10 parts by mass of 1,3-butanediol, stir until transparent, and then defoam; cool to 40-45°C and add 2 parts by mass of hexanediol, use citric acid or potassium hydroxide to adjust the pH to 8-9, and make up the remainder to 100 with deionized water, and continue to mix and stir at a speed of 100 rpm for 15-20 minutes. Then cool the mixture to room temperature, and let it stand at room temperature for 12 hours for standby use.

[0161] Test Example 5: Stability and Usability Test

[0162] The specific method for investigating the stability and usability of Examples 9-12 is as follows:

[0163] Stability evaluation method: The liquid cleaning compositions prepared in Examples 9-12 were placed in a thermostat at high temperature (48°C, 25°C, 4°C) for 30 days. The samples were observed to see if there were any solid particles precipitating out, jelloing, or stratification. If the sample was normal and unchanged before and after a certain time within 30 days, it was considered "passed", the presence of particles was considered "precipitation", the solidification of the material that was difficult to flow was considered "jelly", and the presence of two layers of liquid was considered "stratification".

[0164] Usability evaluation method:

[0165] The 5-member evaluation team observed and tried the product, then scored it and took the average of the five-member evaluation team. The product appearance score (material texture color) and the use experience score (foam volume and cleanliness) are evaluated. Among them, the material texture color is 0-10 points: 0-3 points are turbid material and abnormal color, 4-6 points are translucent material and normal color, 7 points-10 points are transparent material and normal color. The higher the score, the higher the transparency and the more attractive the appearance to consumers; and the use experience score (foam volume and cleanliness) is 0-10 points: 0-3 points are less foam or poor cleaning power, 4-6 points are general cleaning feeling or moderate foam, 7 points-10 points are good washing feeling, strong cleaning power or rich foam, and the higher the score, the better the use experience.

[0166] Table 11 shows the stability and usability test results of various preservative-free cleaning compositions.

[0167] Table 11

[0168]

[0169] Conclusion: The cleaning compositions of Examples 9-12 are all composed of amphoteric surfactants and anionic surfactants, and have the same active ingredient content, about 25% of active ingredients, so the usability of Examples 9-12 is maintained at an excellent level. The different addition amounts of EDTA-2Na do not affect the appearance and stability of the formula system, and the texture and color of the material are all good, and the 30-day stability has passed.

[0170] Test Example 6: Anticorrosion Challenge Test

[0171] Test sample: Preservative-free cleaning composition prepared in Examples 9-12

[0172] Test bacteria: Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Burkholderia cepacia, Candida albicans, Paecilomyces cerevisiae, Aspergillus niger

[0173] Test bacteria concentration: 10 6 cfu / mL, mold and yeast are 10 5 cfu / mL

[0174] Specific test: 7 kinds of bacteria were mixed and inoculated once, and observed for 28 days.

[0175] The results are shown in Tables 12-15.

[0176] Table 12: Preservative Challenge Results for Non-Preservative Cleaning Composition Example 9

[0177]

[0178] Table 13: Preservative Challenge Results for Non-Preservative Cleaning Composition Example 10

[0179]

[0180] Table 14: Preservative Challenge Results for Non-Preservative Cleaning Composition Example 11

[0181]

[0182] Table 15: Preservative Challenge Results for Example 12 of Non-Preservative Cleaning Composition

[0183]

[0184] Conclusion: The cleaning compositions of Examples 9-12 are all composed of amphoteric surfactants and anionic surfactants, and have the same active ingredient content, all containing about 25% active ingredients, while the addition amount of EDTA-2Na is different, which does not affect the antiseptic properties of the cleaning compositions. According to the results: the addition amount of EDTA-2Na in the range of 0.2-0% can achieve a good antiseptic effect and pass the three-level antiseptic challenge.

[0185] Example 13: Preparation of preservative-free cleaning composition

[0186] Weigh 10 parts by mass of AES, add 30 parts by mass of cocamidopropyl betaine and 30 parts by mass of sodium cocoylamphoacetate, then add 15 parts by mass of deionized water and 0.2 parts by mass of EDTA-2NA, heat to 85-80°C, mix and stir at a speed of 100 rpm until all dissolved, and the material is transparent; cool to 50-55°C, add 10 parts by mass of 1,3-butylene glycol, stir until transparent, and then defoam; cool to 40-45°C and add 2 parts by mass of hexanediol, use citric acid or potassium hydroxide to adjust the pH to 8-9, and make up the remainder to 100 with deionized water, and continue to mix and stir at a speed of 100 rpm for 15-20 minutes. Then cool the mixture to room temperature, let it stand at room temperature for 12 hours, and set aside.

[0187] Example 14: Preparation of preservative-free cleaning composition

[0188] Weigh 10 parts by mass of AES, add 30 parts by mass of cocamidopropyl betaine and 20 parts by mass of sodium cocoylamphoacetate, then add 15 parts by mass of deionized water and 0.2 parts by mass of EDTA-2NA, heat to 85-80°C, mix and stir at a speed of 100 rpm until all dissolved, and the material is transparent; cool to 50-55°C, add 10 parts by mass of 1,3-butanediol, stir until transparent, and then defoam; cool to 40-45°C and add 2 parts by mass of hexanediol, use citric acid or potassium hydroxide to adjust the pH to 8-9, and make up the remainder to 100 with deionized water, and continue to mix and stir at a speed of 100 rpm for 15-20 minutes. Then cool the mixture to room temperature, let it stand at room temperature for 12 hours, and set aside.

[0189] Example 15: Preparation of preservative-free cleaning composition

[0190] Weigh 10 parts by mass of AES, add 20 parts by mass of cocamidopropyl betaine and 30 parts by mass of sodium cocoylamphoacetate, then add 15 parts by mass of deionized water and 0.2 parts by mass of EDTA-2NA, heat to 85-80°C and mix and stir at a speed of 100 rpm until all dissolved and the material is transparent; cool to 50-55°C, add 10 parts by mass of 1,3-butylene glycol, stir until transparent and then defoam; cool to 40-45°C and add 2 parts by mass of hexanediol, use citric acid or potassium hydroxide to adjust the pH to 8-9, and make up the remainder to 100 with deionized water, and continue to mix and stir at a speed of 100 rpm for 15-20 minutes. Then cool the mixture to room temperature, let it stand at room temperature for 12 hours, and set aside.

[0191] Example 16: Preparation of preservative-free cleaning composition

[0192] Weigh 5 parts by mass of AES, add 30 parts by mass of cocamidopropyl betaine and 30 parts by mass of sodium cocoylamphoacetate, then add 15 parts by mass of deionized water and 0.2 parts by mass of EDTA-2NA, heat to 85-80°C and mix and stir at a speed of 100 rpm until all dissolved and the material is transparent; cool to 50-55°C, add 10 parts by mass of 1,3-butylene glycol, stir until transparent and then defoam; cool to 40-45°C and add 2 parts by mass of hexanediol, use citric acid or potassium hydroxide to adjust the pH to 8-9, and make up the remainder to 100 with deionized water, and continue to mix and stir at a speed of 100 rpm for 15-20 minutes. Then cool the mixture to room temperature, let it stand at room temperature for 12 hours, and set aside.

[0193] Example 17: Preparation of preservative-free cleaning composition

[0194] Weigh 30 parts by mass of cocamidopropyl betaine and 30 parts by mass of sodium cocoylamphoacetate, add 15 parts by mass of deionized water and 0.2 parts by mass of EDTA-2NA, heat to 85-80°C, mix and stir at a speed of 100 rpm until all dissolved and the material is transparent; cool to 50-55°C, add 10 parts by mass of 1,3-butylene glycol, stir until transparent and then defoam; cool to 40-45°C and add 2 parts by mass of hexylene glycol, use citric acid or potassium hydroxide to adjust the pH to 8-9, and make up the remainder to 100 with deionized water, and continue to mix and stir at a speed of 100 rpm for 15-20 minutes. Then cool the mixture to room temperature, let it stand at room temperature for 12 hours, and set aside.

[0195] Example 18: Preparation of preservative-free cleaning composition

[0196] Weigh 5 parts by mass of AES, add 30 parts by mass of cocamidopropyl betaine and 20 parts by mass of sodium cocoylamphoacetate, then add 15 parts by mass of deionized water and 0.2 parts by mass of EDTA-2NA, heat to 85-80°C and mix and stir at a speed of 100 rpm until all dissolved and the material is transparent; cool to 50-55°C, add 10 parts by mass of 1,3-butanediol, stir until transparent and then defoam; cool to 40-45°C and add 2 parts by mass of hexanediol, use citric acid or potassium hydroxide to adjust the pH to 8-9, and make up the remainder to 100 with deionized water, and continue to mix and stir at a speed of 100 rpm for 15-20 minutes. Then cool the mixture to room temperature, let it stand at room temperature for 12 hours, and set aside.

[0197] Example 19: Preparation of preservative-free cleaning composition

[0198] Weigh 5 parts by mass of AES, add 20 parts by mass of cocamidopropyl betaine and 20 parts by mass of sodium cocoylamphoacetate, then add 15 parts by mass of deionized water and 0.2 parts by mass of EDTA-2NA, heat to 85-80°C and mix and stir at a speed of 100 rpm until all dissolved and the material is transparent; cool to 50-55°C, add 10 parts by mass of 1,3-butanediol, stir until transparent and then defoam; cool to 40-45°C and add 2 parts by mass of hexanediol, use citric acid or potassium hydroxide to adjust the pH to 8-9, and make up the remainder to 100 with deionized water, and continue to mix and stir at a speed of 100 rpm for 15-20 minutes. Then cool the mixture to room temperature, let it stand at room temperature for 12 hours, and set aside.

[0199] Example 20: Preparation of preservative-free cleaning composition

[0200] Weigh 30 parts by mass of cocamidopropyl betaine and 20 parts by mass of sodium cocoylamphoacetate, add 15 parts by mass of deionized water and 0.2 parts by mass of EDTA-2NA, heat to 85-80°C, mix and stir at a speed of 100 rpm until all dissolved and the material is transparent; cool to 50-55°C, add 10 parts by mass of 1,3-butylene glycol, stir until transparent and then defoam; cool to 40-45°C and add 2 parts by mass of hexylene glycol, use citric acid or potassium hydroxide to adjust the pH to 8-9, and make up the remainder to 100 with deionized water, and continue to mix and stir at a speed of 100 rpm for 15-20 minutes. Then cool the mixture to room temperature, let it stand at room temperature for 12 hours, and set aside.

[0201] Example 21: Preparation of preservative-free cleaning composition

[0202] Weigh 20 parts by mass of cocamidopropyl betaine and 20 parts by mass of sodium cocoylamphoacetate, add 15 parts by mass of deionized water and 0.2 parts by mass of EDTA-2NA, heat to 85-80°C, mix and stir at a speed of 100 rpm until all dissolved and the material is transparent; cool to 50-55°C, add 10 parts by mass of 1,3-butylene glycol, stir until transparent and then defoam; cool to 40-45°C and add 2 parts by mass of hexylene glycol, use citric acid or potassium hydroxide to adjust the pH to 8-9, and make up the remainder to 100 with deionized water, and continue to mix and stir at a speed of 100 rpm for 15-20 minutes. Then cool the mixture to room temperature, let it stand at room temperature for 12 hours, and set aside.

[0203] Test Example 6: Stability and Usability Test

[0204] The specific methods for investigating the stability and usability of Examples 13-21 are as follows:

[0205] Stability evaluation method: The liquid cleaning compositions prepared in Examples 13-21 were placed in a thermostat at a high temperature (48°C, 25°C, 4°C) for 30 days. The samples were observed to see if there were any solid particles precipitating out, jelloing, or stratification. If the sample was normal and unchanged before and after a certain time within 30 days, it was considered "passed", the presence of particles was considered "precipitation", the solidification of the material that was difficult to flow was considered "jelly", and the presence of two layers of liquid was considered "stratification".

[0206] Usability evaluation method:

[0207] The 5-member evaluation team observed and tried the product, then scored it and took the average of the five-member evaluation team. The product appearance score (material texture color) and the use experience score (foam volume and cleanliness) are evaluated. Among them, the material texture color is 0-10 points: 0-3 points are turbid material and abnormal color, 4-6 points are translucent material and normal color, 7 points-10 points are transparent material and normal color. The higher the score, the higher the transparency and the more attractive the appearance to consumers; and the use experience score (foam volume and cleanliness) is 0-10 points: 0-3 points are less foam or poor cleaning power, 4-6 points are general cleaning feeling or moderate foam, 7 points-10 points are good washing feeling, strong cleaning power or rich foam, and the higher the score, the better the use experience.

[0208] Table 16 shows the stability and usability test results of various preservative-free cleaning compositions.

[0209] Table 16

[0210]

[0211] Conclusion: The cleaning compositions of Examples 13-21 are all composed of amphoteric surfactants and anionic surfactants, and the active ingredient content varies, ranging from 25% to 12%. Therefore, the usability of Examples 13-18 is maintained at an excellent level, while Examples 19-21 have a lower usability score due to their lower surfactant content, and are not suitable for use as cleaning products. However, the change in the surfactant content of the preservative-free cleaning composition does not affect its appearance and the stability of the formula system. The material texture and color are all good, and the 30-day stability has passed.

[0212] Test Example 8: Anticorrosion Challenge Test

[0213] Test sample: Preservative-free cleaning composition prepared in Examples 13-21

[0214] Test bacteria: Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Burkholderia cepacia, Candida albicans, Paecilomyces cerevisiae, Aspergillus niger

[0215] Test bacteria concentration: 10 6cfu / mL, mold and yeast are 10 5 cfu / mL

[0216] Specific test: 7 kinds of bacteria were mixed and inoculated once, and observed for 28 days.

[0217] The results are shown in Tables 17-25.

[0218] Table 17: Preservative Challenge Results for Non-Preservative Cleaning Composition Example 13

[0219]

[0220] Table 18: Preservative Challenge Results for Non-Preservative Cleaning Composition Example 14

[0221]

[0222] Table 19: Preservative Challenge Results for Non-Preservative Cleaning Composition Example 15

[0223]

[0224] Table 20: Preservative Challenge Results for No-Preservative Cleaning Composition Example 16

[0225]

[0226] Table 21: Preservative Challenge Results for Non-Preservative Cleaning Composition Example 17

[0227]

[0228] Table 22: Preservative Challenge Results for No-Preservative Cleaning Composition Example 18

[0229]

[0230] Table 23: Preservative Challenge Results for Non-Preservative Cleaning Composition Example 19

[0231]

[0232] Table 24: Preservative Challenge Results for Non-Preservative Cleaning Composition Example 20

[0233]

[0234] Table 25: Preservative Challenge Results for Non-Preservative Cleaning Composition Example 21

[0235]

[0236] Conclusion: The cleaning compositions of Examples 13-21 are all composed of amphoteric surfactants and anionic surfactants, and the active ingredient content is different, containing 25%-18% of active ingredients, but the formulation system with different content of active ingredients does not affect the antiseptic performance of the cleaning composition. According to the results, the cleaning compositions containing 25%-18% of active ingredients can achieve good antiseptic effects and pass the three-level antiseptic challenge.

Claims

1. A preservative-free cleaning composition comprising: 20-70% by weight of an amphoteric surfactant, wherein the amphoteric surfactant is a combination of an amphoteric acetate surfactant and a betaine surfactant; 5-25 wt% 1,3-butanediol; and A personal care acceptable carrier.

2. The cleaning composition according to claim 1, wherein The composition comprises 30-60% by weight of an amphoteric surfactant.

3. The cleaning composition according to claim 2, wherein The amphoteric acetate surfactant is sodium cocoylamphoacetate, and the betaine surfactant is cocamidopropyl betaine.

4. The cleaning composition according to claim 1, wherein The weight ratio of the amphoteric acetate surfactant to the betaine surfactant is 2:3 to 3:

2.

5. The cleaning composition of claim 1, further comprising an anionic surfactant, wherein the anionic surfactant is AES.

6. The cleaning composition of claim 5, comprising 1-10 wt% of anionic surfactant.

7. The cleaning composition according to claim 1, wherein The composition comprises 5-20 wt% 1,3-butanediol.

8. The cleaning composition according to claim 1, wherein the pH value of the composition is 7-10.

9. Use of the composition according to any one of claims 1 to 8 in personal care products.

10. The use according to claim 9, wherein the personal care product is selected from the group consisting of: baby shower gel, baby shampoo, baby shampoo and body wash, children's hand soap, adult shower gel, adult shampoo, adult hand soap and adult facial cleanser.

Images