Hair washing composition, application thereof and shampoo

Abstract

The invention provides a shampoo composition, application thereof and shampoo. The shampoo composition is prepared from salicylic acid, capryloyl glycine and glyceryl laurate, and the weight ratio of the salicylic acid to the capryloyl glycine to the glyceryl laurate is (0.1-2): (0.01-1.2): (0.04-2). Through compounding of salicylic acid, capryloyl glycine and glyceryl laurate, excellent effects of removing dandruff, controlling oil, relieving itching and preserving moisture are achieved from the multi-dimensional effects of inhibiting malassezia, regulating and controlling scalp cuticle metabolism, controlling oil secretion, keeping scalp moisture and maintaining scalp barriers, so that the health of scalp and hair is maintained. The three components are compounded for use, so that the rapid antibacterial effect on malassezia can be remarkably improved, the inhibition rate on malassezia can reach 80% or above even under a high pH value, and the irritation is reduced while a good anti-dandruff effect is achieved.

Description

Technical Field

[0001] The present application relates to the technical field of daily chemical products, and in particular to a shampoo composition and its application and shampoo. Background Art

[0002] According to the 2024 China Shampoo and Hair Care Product Report, dandruff is a problem that most consumers are worried about, accounting for 59%, far exceeding other hair problems, indicating that although shampoo products claiming to have anti-dandruff effects are not uncommon, consumer demand has not been fully met. In addition, itchy scalp and oily scalp / hair roots are also hair problems that consumers are concerned about, and scalp care products have further room for development. Summary of the invention

[0003] Based on this, the present application provides a shampoo composition having anti-dandruff, oil control and antipruritic effects, and its application and shampoo.

[0004] The first aspect of the present application provides a shampoo composition, which comprises salicylic acid, capryloyl glycine and glyceryl laurate, wherein the weight ratio of salicylic acid, capryloyl glycine and glyceryl laurate is (0.1-2):(0.01-1.2):(0.04-2).

[0005] In some embodiments, the weight ratio of salicylic acid, capryloyl glycine and glyceryl laurate is (0.2-2):(0.02-1.2):(0.05-2), optionally (0.2-2):(0.02-1):(0.05-1.5), and further optionally (0.3-1.5):(0.05-0.5):(0.1-1).

[0006] The second aspect of the present application provides a use of the shampoo composition of the first aspect of the present application in the preparation of a shampoo with anti-dandruff, oil-control and itching effects.

[0007] The third aspect of the present application provides a shampoo, which includes a shampoo composition. Based on 100 parts by weight of the shampoo, the shampoo composition includes 0.1 to 2 parts of salicylic acid, 0.01 to 1.2 parts of capryloyl glycine and 0.04 to 2 parts of glyceryl laurate.

[0008] In some embodiments, based on 100 parts by weight of the shampoo, the shampoo composition comprises 0.2-2 parts of salicylic acid, 0.02-1.2 parts of capryloyl glycine, and 0.05-2 parts of glyceryl laurate;

[0009] Optionally, based on 100 parts by weight of the shampoo, the shampoo composition comprises 0.2 to 2 parts of salicylic acid, 0.02 to 1 part of capryloyl glycine and 0.05 to 1.5 parts of glyceryl laurate;

[0010] Optionally, based on 100 parts by weight of the shampoo, the shampoo composition comprises 0.3 to 1.5 parts of salicylic acid, 0.05 to 0.5 parts of capryloyl glycine and 0.1 to 1 part of glyceryl laurate.

[0011] In some embodiments, the shampoo further comprises at least one of anionic surfactants, nonionic surfactants, and zwitterionic surfactants;

[0012] Optionally, the shampoo further comprises one or more of a cationic conditioning agent, a thickener and a pH adjuster.

[0013] In some embodiments, based on 100 parts by weight of the shampoo, the weight of the anionic surfactant contained in the shampoo is 0-15 parts, optionally 6-15 parts; and / or

[0014] The anionic surfactant includes one or more of sodium lauryl sulfate, ammonium lauryl sulfate, sodium laureth sulfate and ammonium laureth sulfate.

[0015] In some embodiments, based on 100 parts by weight of the shampoo, the weight of the nonionic surfactant contained in the shampoo is 0-2 parts, optionally 0.5 parts to 2 parts; and / or

[0016] The nonionic surfactant includes one or more of decyl glucoside, octyl / decyl glucoside, lauryl glucoside and coconut glucoside.

[0017] In some embodiments, based on 100 parts by weight of the shampoo, the weight of the zwitterionic surfactant contained in the shampoo is 0-8 parts, optionally 1.5 parts to 8 parts; and / or

[0018] The zwitterionic surfactant includes one or more of cocamidopropyl betaine, lauryl hydroxysulfonate and sodium lauroamphoacetate.

[0019] In some embodiments, based on 100 parts by weight of the shampoo, the weight of the cationic conditioning agent contained in the shampoo is 0-1 part, optionally 0.1 part to 1 part; and / or

[0020] The cationic conditioning agent includes one or more of behentrimonium chloride, stearamidopropyl dimethylamine, guar hydroxypropyltrimonium chloride, polyquaternium-7, polyquaternium-10, polyquaternium-11, polyquaternium-22, and polyquaternium-67.

[0021] In some embodiments, based on 100 parts by weight of the shampoo, the weight of the thickener contained in the shampoo is 0-3 parts, optionally 0.1 parts to 3 parts; and / or

[0022] The thickener includes one or more of cocamide MEA, cocamide methyl MEA and PEG-150 distearate.

[0023] In some embodiments, the pH adjuster includes one or more of citric acid, sodium citrate and sodium hydroxide; and / or

[0024] The pH regulator is used in an amount such that the pH value of the shampoo reaches 5-7;

[0025] Optionally, based on 100 parts by weight of the shampoo, the weight of the pH regulator contained in the shampoo is 0-3 parts, optionally 0.01 parts to 3 parts.

[0026] In some embodiments, based on 100 parts by weight of the shampoo, the shampoo comprises:

[0027] 0.2-2 parts of salicylic acid, 0.02-1 parts of capryloyl glycine, 0.05-1.5 parts of glyceryl laurate, 6-15 parts of the anionic surfactant, 0.5-2 parts of the nonionic surfactant, 1.5-8 parts of the zwitterionic surfactant, 0.1-1 parts of the cationic conditioning agent, 0.1-3 parts of the thickener and 0.01-3 parts of the pH adjuster.

[0028] In some embodiments, the shampoo further comprises water.

[0029] In some embodiments, the pH value of the shampoo is 5-7.

[0030] The shampoo composition provided above, by specifically compounding salicylic acid, capryloyl glycine and glyceryl laurate, has at least the following beneficial effects:

[0031] (1) Salicylic acid, capryloyl glycine and glyceryl laurate all have certain antibacterial effects. The combined use of the three can significantly improve the rapid antibacterial effect on Malassezia. Even at a higher pH, the inhibition rate of Malassezia can reach more than 80%, which has a better anti-dandruff effect and reduces irritation.

[0032] (2) Through the combination of salicylic acid, capryloyl glycine and glyceryl laurate, it has multiple effects on inhibiting Malassezia, regulating the metabolism of the scalp stratum corneum, controlling oil secretion, maintaining scalp moisture, and maintaining the scalp barrier, achieving excellent dandruff removal, oil control, anti-itching and moisturizing effects, thereby maintaining the health of the scalp and hair. DETAILED DESCRIPTION

[0033] For ease of understanding of the present invention, the application will be described more fully below with reference to relevant embodiments. The following provides preferred embodiments of the application. However, the application can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the understanding of the disclosure of the application more thorough and comprehensive.

[0034] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art to which this application belongs. The terms used herein in the specification of this application are only for the purpose of describing specific embodiments and are not intended to limit this application.

[0035] The terms "and / or", "or / and", and "and / or" used herein include any one of two or more related listed items, and also include any and all combinations of the related listed items, wherein the any and all combinations include any combination of two related listed items, any more related listed items, or all related listed items. It should be noted that when at least three items are connected by at least two conjunctions selected from "and / or", "or / and", and "and / or", it should be understood that in the present application, the technical solution undoubtedly includes technical solutions connected by "logical and", and also undoubtedly includes technical solutions connected by "logical or".

[0036] In the present application, the technical features described in an open manner include closed technical solutions composed of the listed features, and also include open technical solutions containing the listed features.

[0037] In this application, when it comes to numerical ranges, unless otherwise specified, the above numerical ranges are deemed to be continuous and include the minimum and maximum values ​​of the range, as well as each value between such minimum and maximum values. Further, when a range refers to an integer, each integer between the minimum and maximum values ​​of the range is included. In addition, when multiple ranges are provided to describe features or characteristics, the ranges can be merged. In other words, unless otherwise specified, all ranges disclosed herein should be understood to include any and all subranges included therein.

[0038] Only some numerical ranges are specifically disclosed herein. However, any lower limit can be combined with any upper limit to form an unspecified range; and any lower limit can be combined with other lower limits to form an unspecified range, and likewise any upper limit can be combined with any other upper limit to form an unspecified range. In addition, each separately disclosed point or single value can itself be combined as a lower limit or upper limit with any other point or single value or with other lower limits or upper limits to form an unspecified range.

[0039] The temperature parameters in this application, unless otherwise specified, allow both constant temperature treatment and treatment within a certain temperature range. The constant temperature treatment allows the temperature to fluctuate within the accuracy range controlled by the instrument. Fluctuations within the range of ±5°C, ±4°C, ±3°C, ±2°C, and ±1°C are allowed.

[0040] Herein, the “suitable” mentioned in “suitable combination”, “suitable method”, “any suitable method”, etc., shall be based on the ability to implement the technical solution of this application, solve the technical problems of this application, and achieve the expected technical effects of this application.

[0041] In the present application, "further", "further", "particularly" and the like are used for descriptive purposes to indicate differences in content, but should not be construed as limiting the scope of protection of the present application.

[0042] In this application, "optionally", "optional", and "optional" mean optional or dispensable, that is, any one of the two parallel schemes of "yes" or "no". If multiple "options" appear in a technical solution, unless otherwise specified and there is no contradiction or mutual restriction, each "optional" is independent.

[0043] In the description of the application, "plurality" means at least two, such as two, three, etc., unless otherwise clearly and specifically defined.

[0044] Unless otherwise specified, all formulations and tests herein took place at 25°C.

[0045] As used herein, "includes," "comprising," "containing," "having," or other variations thereof are intended to encompass non-closed inclusions, and no distinction is made between these terms. The term "comprising" means that other steps and ingredients that do not affect the end result may be added. The compositions and methods / processes of the present invention comprise, consist of, and consist essentially of the essential elements and limitations described herein, as well as any additional or optional ingredients, components, steps, or limitations described herein. As used herein, no distinction is made between the terms "efficacy," "performance," "effect," and "efficacy."

[0046] If there is no special description, all embodiments and optional embodiments of the present application can be combined with each other to form a new technical solution. If there is no special description, all technical features and optional technical features of the present application can be combined with each other to form a new technical solution.

[0047] If there is no special explanation, all the steps of the present application can be performed sequentially or randomly, preferably sequentially.

[0048] Dandruff is the accumulation of tiny white or gray scales on the surface of the scalp. Studies have shown that the formation of dandruff is related to the fungus Malassezia. Malassezia is a fungus with lipase activity. When the scalp secretes too much sebum, the Malassezia on the scalp secretes lipase to break down the triglycerides and saturated fatty acids in the sebum into unsaturated fatty acids. Unsaturated fatty acids are pro-inflammatory and can penetrate into the stratum corneum of the scalp, which can not only cause itching of the scalp, but also allow calcium ions to flow into the scalp cells, which will further lead to excessive keratinization of the scalp keratinocytes, thereby causing abnormal scalp keratinization and accelerating the production of dandruff.

[0049] Another reason for dandruff is imbalance in sebum secretion. Under normal circumstances, sebum emulsifies to form a sebum film to protect the health of the scalp, but when sebum secretion is too strong, it will provide a rich source of nutrition for the colonization of microorganisms. In addition, the oil on the scalp is easily oxidized by ultraviolet rays to produce lipid peroxides, which will further stimulate the scalp, leading to further increase in scalp lipid secretion and an increase in dandruff. On the contrary, since sebum has a certain adhesive effect on the stratum corneum, if sebum is secreted too little, it is not enough to protect the scalp, resulting in insufficient scalp moisture retention, dryness and itching, further weakening of the scalp barrier function, and decreased activity of the protease responsible for the shedding of epidermal cells, resulting in the inability of epidermal cells to shed normally, which will also lead to the production of dandruff.

[0050] Therefore, in order to achieve a better anti-dandruff effect, three points need to be achieved: inhibiting the excessive reproduction of Malassezia, controlling the oil secretion of the scalp, and repairing the scalp barrier. Antifungal antidandruff agents mainly include zinc pyrithione (ZPT), piroctone ethanolamine (OCT), and climbazole. This type of antidandruff agent has a strong inhibitory effect on Malassezia, but it is also relatively irritating, and has weak effects in oil control, itching, and repairing the scalp barrier. Exfoliating antidandruff agents mainly include salicylic acid and sulfur. The mechanism of action of this type of antidandruff agent is mainly to promote the softening and shedding of scalp stratum corneum cells. The antifungal effect is weak, and it will also be highly irritating when used alone. In addition, for rinse-off hair care products, the difficulty in achieving a better anti-dandruff effect lies in the fact that this type of product has a short action time and the effective ingredients are difficult to remain on the scalp. Therefore, it is necessary to add effective ingredients that can take effect quickly in a short time or are relatively easier to remain on the scalp. Based on the above problems, the present application combines salicylic acid, capryloyl glycine and glyceryl laurate to achieve the effects of dandruff removal, oil control and itching relief through the effects of antibacterial, regulating oil secretion, promoting stratum corneum metabolism, and moisturizing and repairing the scalp.

[0051] One or more embodiments of the present application provide a shampoo composition, which includes salicylic acid, capryloyl glycine and glyceryl laurate, and the weight ratio of salicylic acid, capryloyl glycine and glyceryl laurate is (0.1-2):(0.01-1.2):(0.04-2).

[0052] As non-limiting examples, the weight ratio of salicylic acid, capryloyl glycine and glyceryl laurate can be, but is not limited to, (0.1-2):(0.01-1.2):(0.04-2), (0.2-2):(0.02-1.2):(0.05-2), (0.2-2):(0.02-1):(0.05-1.5), (0.3-1.7):(0.02-1):(0.05-1.5), (0.3-1.5):(0.02-0.8):(0.05-1.3), (0.3-1.5):(0.05-0.5):(0.1-1) , (0.5-1.4):(0.05-0.7):(0.07-1), (0.7-1.2):(0.1-0.5):(0.1-0.8) or (0.8-1):(0.3-0.5):(0.3-0.5), etc.

[0053] Salicylic acid can promote the softening and shedding of abnormal keratinized scalp stratum corneum, and at the same time, it can inhibit Malassezia to a certain extent under weak acid conditions. If the amount of salicylic acid added is too low, the anti-dandruff and antibacterial effects will not be good; if the amount of salicylic acid added is too high, it may be irritating to the scalp.

[0054] Capryloyl glycine has a certain antibacterial effect, and the antibacterial effect can be synergistically enhanced when used in combination with salicylic acid. If the amount of capryloyl glycine added is too low, the oil control effect and antibacterial effect are not ideal; if the amount of capryloyl glycine added is too high, the oil control effect and antibacterial effect are not significantly increased, and the cost will increase.

[0055] Glyceryl laurate has a certain antibacterial effect. When combined with salicylic acid and capryloyl glycine, the inhibitory effect on Malassezia is significantly improved. At the same time, as an oil-soluble fat excipient, glyceryl laurate has a certain moisturizing and barrier repair effect on the scalp, which can reduce the irritation of salicylic acid to a certain extent. If the amount of glyceryl laurate added is too low, the moisturizing effect on the scalp is poor, and the enhancement effect on the antibacterial effect is also poor; if the amount added is too high, it has a negative impact on the oil control effect and may also reduce the amount of foam.

[0056] It can be understood that by compounding salicylic acid, capryloyl glycine and glyceryl laurate in a specific ratio, a synergistic effect is achieved, which has at least the following beneficial effects:

[0057] (1) Salicylic acid, capryloyl glycine and glyceryl laurate all have certain antibacterial effects. The combined use of the three can significantly improve the rapid antibacterial effect on Malassezia. Even at a higher pH, the inhibition rate of Malassezia can reach more than 80%, which has a better anti-dandruff effect and reduces irritation.

[0058] (2) Through the combination of salicylic acid, capryloyl glycine and glyceryl laurate, it has multiple effects on inhibiting Malassezia, regulating the metabolism of the scalp stratum corneum, controlling oil secretion, maintaining scalp moisture, and maintaining the scalp barrier, achieving excellent dandruff removal, oil control, anti-itching and moisturizing effects, thereby maintaining the health of the scalp and hair.

[0059] As a possible implementation manner, the weight ratio of salicylic acid, capryloyl glycine and glyceryl laurate is (0.2-2):(0.02-1.2):(0.05-2).

[0060] In some optional embodiments, the weight ratio of salicylic acid, capryloyl glycine and glyceryl laurate is (0.2-2):(0.02-1):(0.05-1.5).

[0061] In some exemplary embodiments, the weight ratio of salicylic acid, capryloyl glycine and glyceryl laurate is (0.3-1.5):(0.05-0.5):(0.1-1).

[0062] One or more embodiments of the present application provide a use of the above-mentioned shampoo composition in the preparation of a shampoo with anti-dandruff, oil-controlling and antipruritic effects.

[0063] One or more embodiments of the present application provide a shampoo, which includes a shampoo composition. Based on 100 parts by weight of the shampoo, the shampoo composition includes 0.1 to 2 parts of salicylic acid, 0.01 to 1.2 parts of capryloyl glycine, and 0.04 to 2 parts of glyceryl laurate.

[0064] As a non-limiting example, the weight proportion of salicylic acid contained in the shampoo composition can be but is not limited to 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 part, 1 part, 1.1 part, 1.2 parts, 1.3 parts, 1.4 parts, 1.5 parts, 1.6 parts, 1.7 parts, 1.8 parts, 1.9 parts, 2 parts or a range between any two of the above weight proportions, etc.

[0065] The weight proportion of capryloyl glycine in the shampoo composition may be, but is not limited to, 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1, 1.1, 1.2 or ranges between any two of the above weight proportions.

[0066] The weight proportion of glyceryl laurate contained in the shampoo composition can be, but is not limited to, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2 or a range between any two of the above weight proportions.

[0067] It should be noted that the effects of salicylic acid, capryloyl glycine and glyceryl laurate in shampoo are the same as those in the shampoo composition, and will not be described in detail here.

[0068] It can be understood that by compounding salicylic acid, capryloyl glycine and glyceryl laurate in a specific proportion, a synergistic effect is achieved, which can inhibit Malassezia, regulate the metabolism of the scalp stratum corneum, control oil secretion, maintain scalp moisture, and maintain the scalp barrier in multiple dimensions, so that the shampoo can achieve excellent dandruff removal, oil control, anti-itching and moisturizing effects, thereby maintaining the health of the scalp and hair.

[0069] In some optional embodiments, based on 100 parts by weight of the shampoo, the shampoo composition includes 0.2 to 2 parts of salicylic acid, 0.02 to 1.2 parts of capryloyl glycine and 0.05 to 2 parts of glyceryl laurate.

[0070] As a possible implementation, based on 100 parts by weight of the shampoo, the shampoo composition includes 0.2 to 2 parts of salicylic acid, 0.02 to 1 part of capryloyl glycine, and 0.05 to 1.5 parts of glyceryl laurate.

[0071] In some exemplary embodiments, based on 100 parts by weight of the shampoo, the shampoo composition includes 0.3 to 1.5 parts of salicylic acid, 0.05 to 0.5 parts of capryloyl glycine, and 0.1 to 1 part of glyceryl laurate.

[0072] In some embodiments, the shampoo further includes at least one of anionic surfactants, nonionic surfactants, and zwitterionic surfactants.

[0073] In some embodiments, the shampoo further comprises one or more of a cationic conditioning agent, a thickening agent, and a pH adjusting agent.

[0074] In some embodiments, based on 100 parts by weight of the shampoo, the weight proportion of the anionic surfactant contained in the shampoo is 0-15 parts; for example, it can be but is not limited to 0 parts, 1 parts, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts or a range between any two of the above parts by weight, etc.

[0075] In some optional embodiments, the weight percentage of the anionic surfactant contained in the shampoo is 6-15 parts based on 100 parts by weight of the shampoo. Since the anionic surfactant has strong foaming and cleaning power, when the amount of the anionic surfactant is within this range, it can ensure a relatively good cleaning and degreasing effect on oily scalp and hair without providing excessive degreasing power.

[0076] In some exemplary embodiments, the anionic surfactant includes one or more of sodium lauryl sulfate, ammonium lauryl sulfate, sodium laureth sulfate, and ammonium laureth sulfate.

[0077] As a possible implementation manner, based on 100 parts by weight of the shampoo, the weight proportion of the nonionic surfactant contained in the shampoo is 0-2 parts; for example, it can be but is not limited to 0 parts, 0.1 parts, 0.2 parts, 0.3 parts, 0.4 parts, 0.5 parts, 0.6 parts, 0.7 parts, 0.8 parts, 0.9 parts, 1 parts, 1.1 parts, 1.2 parts, 1.3 parts, 1.4 parts, 1.5 parts, 1.6 parts, 1.7 parts, 1.8 parts, 1.9 parts, 2 parts or the range between any two parts by weight, etc.

[0078] As a possible implementation, based on 100 parts by weight of the shampoo, the weight of the nonionic surfactant contained in the shampoo is 0.5 to 2 parts. As a result, the nonionic surfactant has a stronger affinity for grease and can synergistically enhance the effect of cleaning grease.

[0079] In some embodiments thereof, the nonionic surfactant includes one or more of decyl glucoside, octyl / decyl glucoside, lauryl glucoside, and coco-glucoside.

[0080] In some embodiments, based on 100 parts by weight of the shampoo, the weight of the zwitterionic surfactant contained in the shampoo is 0-8 parts; for example, it can be but not limited to 0 parts, 0.5 parts, 1 parts, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, 5.5 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 8 parts or the range between any two parts by weight. Optionally, based on 100 parts by weight of the shampoo, the weight of the zwitterionic surfactant contained in the shampoo is 1.5 parts to 8 parts. Thus, the zwitterionic surfactant can synergistically increase and stabilize foam, while improving the mildness of the shampoo, reducing or even avoiding scalp irritation.

[0081] As a possible implementation, the zwitterionic surfactant includes one or more of cocamidopropyl betaine, lauryl hydroxysulfonate and sodium lauroamphoacetate.

[0082] In some embodiments, based on 100 parts by weight of the shampoo, the weight portion of the cationic conditioning agent contained in the shampoo is 0-1 part; for example, it can be but not limited to 0 part, 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 part, 1 part or a range between any two of the above parts by weight, etc.

[0083] In some optional embodiments, the weight portion of the cationic conditioning agent contained in the shampoo is 0.1-1 part, based on 100 parts by weight of the shampoo. Thus, the addition of the cationic conditioning agent can reduce the friction and tangle-proneness of the hair, making the hair smooth and easy to comb, and reducing the irritation and damage to the scalp and hair caused by excessive pulling during the shampooing and combing process.

[0084] In some exemplary embodiments, the cationic conditioning agent includes one or more of behentrimonium chloride, stearamidopropyl dimethylamine, guar hydroxypropyltrimonium chloride, polyquaternium-7, polyquaternium-10, polyquaternium-11, polyquaternium-22, and polyquaternium-67.

[0085] In some embodiments, based on 100 parts by weight of the shampoo, the weight of the thickener contained in the shampoo is 0-3 parts; for example, it can be but not limited to 0 parts, 0.1 parts, 0.2 parts, 0.4 parts, 0.6 parts, 0.8 parts, 1 parts, 1.2 parts, 1.4 parts, 1.6 parts, 1.8 parts, 2 parts, 2.2 parts, 2.4 parts, 2.6 parts, 2.8 parts, 3 parts or the range between any two of the above parts by weight, etc.

[0086] In some optional embodiments, the weight of the thickener contained in the shampoo is 0.1-3 parts, based on 100 parts by weight of the shampoo. Thus, the system can be provided with a suitable viscosity, which is convenient for use and can also play a certain foam stabilizing role.

[0087] In some exemplary embodiments, the thickener includes one or more of cocamide MEA, cocamide methyl MEA, and PEG-150 distearate.

[0088] In some embodiments, the pH adjuster includes one or more of citric acid, sodium citrate, and sodium hydroxide.

[0089] In some embodiments, the pH adjuster is used in an amount such that the pH value of the shampoo reaches 5-7.

[0090] As a possible implementation manner, based on 100 parts by weight of the shampoo, the weight proportion of the pH adjuster contained in the shampoo is 0-3 parts; for example, it can be but is not limited to 0 parts, 0.01 parts, 0.05 parts, 0.1 parts, 0.2 parts, 0.4 parts, 0.6 parts, 0.8 parts, 1 parts, 1.2 parts, 1.4 parts, 1.6 parts, 1.8 parts, 2 parts, 2.2 parts, 2.4 parts, 2.6 parts, 2.8 parts, 3 parts or the range between any two of the above parts by weight, etc.

[0091] In some optional embodiments, the weight proportion of the pH adjuster contained in the shampoo is 0.01-3 parts based on 100 parts by weight of the shampoo; thereby, it can be ensured that the system is effective within a suitable pH range, and the shampoo has an excellent inhibitory effect on Malassezia while reducing irritation to the scalp and having excellent foaming properties.

[0092] In some embodiments, based on 100 parts by weight of the shampoo, the shampoo comprises:

[0093] 0.2-2 parts of salicylic acid, 0.02-1 parts of capryloyl glycine, 0.05-1.5 parts of glyceryl laurate, 6-15 parts of anionic surfactant, 0.5-2 parts of nonionic surfactant, 1.5-8 parts of zwitterionic surfactant, 0.1-1 parts of cationic conditioning agent, 0.1-3 parts of thickener and 0.01-3 parts of pH adjuster.

[0094] In some embodiments, the shampoo further includes water.

[0095] As a possible implementation, the pH value of the shampoo is 5-7; for example, it may be but is not limited to 5, 5.1, 5.2, 5.3, 5.4, 5.5, 5.6, 5.7, 5.8, 5.9, 6, 6.1, 6.2, 6.3, 6.4, 6.5, 6.6, 6.7, 6.8, 6.9, 7 or a range between any two of the above pH values.

[0096] The technical scheme of the present invention is described in detail below in conjunction with specific embodiments. It should be understood that these embodiments are only used to illustrate the present invention and are not intended to limit the scope of the present invention. The experimental methods for which specific conditions are not specified in the following embodiments are preferably referred to the guidance given in the present invention, and can also be carried out according to the experimental manual or conventional conditions in the art, or according to the conditions recommended by the manufacturer, or with reference to experimental methods known in the art.

[0097] In the following specific embodiments, the measured parameters of raw material components may have slight deviations within the range of weighing accuracy unless otherwise specified. For temperature and time parameters, acceptable deviations caused by instrument test accuracy or operation accuracy are allowed.

[0098] It should be noted that the raw materials used in the above embodiments and comparative examples can be purchased from the market.

[0099] 1. Preparation and testing of shampoo

[0100] 1. Preparation of Examples 1-14 and Comparative Examples 1-6

[0101] The formulation compositions of Examples 1-14 are shown in Table 1. The formulation compositions of Comparative Examples 1-6 are shown in Table 2.

[0102] Table 1

[0103]

[0104] Table 2

[0105]

[0106] It should be noted that each "portion" mentioned above refers to 100g.

[0107] The preparation process is as follows:

[0108] Anionic surfactant and deionized water solvent were mixed and heated to 75°C, and stirred to dissolve completely; shampoo composition was added, stirred at the temperature until it was completely dissolved, and then cooled to room temperature; pH adjuster was added to adjust pH to the pH values ​​in the embodiments and comparative examples shown in the above tables.

[0109] 2. The shampoos prepared in Examples 1-14 and Comparative Examples 1-6 were subjected to antibacterial rate test, foam test and irritation test.

[0110] 2.1 The antibacterial rate test conditions are as follows:

[0111] 1) Test strain: ATCC44344 Malassezia furfur

[0112] 2) Culture medium:

[0113] Peptone 5.0g Yeast extract 3.0g

[0114] Malt extract 3.0g Glucose 10.0g

[0115] Olive oil 10.0g Agar 20.0g

[0116] Distilled water 1.0L

[0117] Adjust pH to 6.0

[0118] 3) Test method: Refer to GB / T 15979 Appendix C C5 Test method for antibacterial performance of non-dissolving antibacterial (inhibitory) products.

[0119] 4) Test concentration: 50% solution.

[0120] 5) Action time: 5 minutes.

[0121] 2.2 The reaction time method of the chicken embryo chorioallantoic membrane test was used for the irritation test. The reaction time irritation evaluation criteria are shown in Table 3.

[0122] Table 3

[0123]

[0124] The test results of the above embodiments and comparative examples are shown in Table 4.

[0125] Table 4

[0126]

[0127] It can be seen from the results in Table 4 that the shampoos provided in the present application all have better Malassezia inhibition rate and foaming results.

[0128] Under the same pH conditions, the inhibition rate of Malassezia by the shampoo provided in the examples of the present application can reach more than 60%, or even more than 80%. However, the inhibition rates of Malassezia in Comparative Examples 1-6 are all lower than 50%, which can prove that the combination of salicylic acid, capryloyl glycine and glyceryl laurate can play a synergistic role and have a better and faster inhibition effect on Malassezia at a higher pH.

[0129] By comparing the results of Example 6 and Example 11, it can be seen that when the weight portion of capryloyl glycine in the shampoo is 1 part, a better antibacterial effect has been achieved; further increasing the amount of capryloyl glycine does not significantly improve the antibacterial effect.

[0130] Comparison of the results of Example 5 and Example 12 shows that when the weight portion of glyceryl laurate in the shampoo is 1.5 parts, a better antibacterial effect has been achieved; further increasing the amount of glyceryl laurate does not significantly improve the antibacterial effect. From the foam test results of Example 5 and Example 12, it can be seen that when the weight portion of glyceryl laurate in the shampoo is 1.5 parts, it has a better antibacterial effect; further increasing the amount of glyceryl laurate reduces the amount of foam and speeds up the defoaming speed.

[0131] From the comparison between Example 4 and Example 7, and the comparison between Example 10, Example 13 and Example 14, it can be seen that the lower the pH value of the shampoo, the better the inhibitory effect on Malassezia, but the irritation of the shampoo will also increase.

[0132] 3. Preparation of Examples 15-17 and Comparative Examples 7-12

[0133] The formulation compositions of Examples 15-17 and Comparative Examples 7-12 are shown in Table 5.

[0134] Table 5

[0135]

[0136] It should be noted that each "portion" mentioned above refers to 100g.

[0137] The preparation process is as follows:

[0138] Step 1), anionic surfactant and solvent deionized water are mixed and heated to 75°C, and stirred to dissolve completely; Step 2), nonionic surfactant, zwitterionic surfactant, thickener, shampoo composition and behenyl trimethyl ammonium chloride and / or stearamidopropyl dimethylamine in the cationic conditioner are added, and the mixture is stirred and kept warm until it is completely dissolved, and then the temperature is lowered to 40°C; Step 3), at least one of guar hydroxypropyl trimethyl ammonium chloride, polyquaternium-7, polyquaternium-10, polyquaternium-11, polyquaternium-22, and polyquaternium-67 in the cationic conditioner is preliminarily stirred and swollen with an appropriate amount of deionized water to form a uniform gel, and then mixed evenly with the solution obtained in step 2); Step 4), a pH adjuster is added to adjust the pH to the pH values ​​of the embodiments and comparative examples shown in Table 5.

[0139] 4. Comparison of the effects of Examples 15-17 and Comparative Examples 7-12.

[0140] The subjects who met the requirements were divided into 9 groups, each with no less than 12 valid persons, and the samples of Examples 15-17 and Comparative Examples 7-12 were tried respectively. The subjects were asked to self-evaluate their scalp conditions before using the test products and 48 hours after using the test samples. The evaluation items included the degree of itching, dandruff, oiliness, dryness of the scalp, etc. The scoring was based on a 10-point system, and the higher the score, the more serious the self-perceived itching / dandruff / oily / dryness of the scalp problem of the subject.

[0141] The use effects are shown in Table 6.

[0142] Table 6

[0143]

[0144] From the comparison of the results in Table 6, it can be seen that the change rates of the oiliness of the scalp, the change rates of the dandruff, the change rates of the itching of the scalp and the change rates of the dry scalp after using the shampoos of Examples 15-17 of the present application once are respectively greater than 50%; while the change rates of the oiliness of the scalp, the change rates of the dandruff, the change rates of the itching of the scalp and the change rates of the dry scalp after using the shampoos of Comparative Examples 7-12 once are respectively significantly lower than 50%. This indicates that the shampoos provided in the embodiments of the present application can significantly improve the problems of oiliness of the scalp, dandruff, itching of the scalp and dry scalp after using them once, and the shampoos of the present application have significant effects of removing dandruff, controlling oil and relieving itching.

[0145] In summary, the shampoo composition provided in the present application can significantly enhance the inhibitory effect on Malassezia through the compounding of salicylic acid, capryloyl glycine and glyceryl laurate, and can also play a multi-dimensional role in regulating the metabolism of the scalp stratum corneum, controlling oil secretion, maintaining scalp moisture, and maintaining the scalp barrier, thereby achieving excellent dandruff removal, oil control, antipruritic and moisturizing effects, and maintaining the health of the scalp and hair.

[0146] The technical features of the above-described embodiments may be arbitrarily combined. To make the description concise, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0147] The above-mentioned embodiments only express several implementation methods of the present invention, and the descriptions thereof are relatively specific and detailed, but they cannot be understood as limiting the scope of the invention patent. It should be pointed out that, for ordinary technicians in this field, several variations and improvements can be made without departing from the concept of the present invention, and these all belong to the protection scope of the present invention. Therefore, the protection scope of the patent of the present invention shall be subject to the attached claims.

Claims

1. A shampoo composition, characterized in that The shampoo composition comprises salicylic acid, capryloyl glycine and glyceryl laurate, and the weight ratio of salicylic acid, capryloyl glycine and glyceryl laurate is (0.1-2):(0.01-1.2):(0.04-2).

2. The shampoo composition according to claim 1, characterized in that The weight ratio of salicylic acid, capryloyl glycine and glyceryl laurate is (0.2-2):(0.02-1.2):(0.05-2), optionally (0.2-2):(0.02-1):(0.05-1.5), and further optionally (0.3-1.5):(0.05-0.5):(0.1-1).

3. Use of the shampoo composition according to any one of claims 1 to 2 in the preparation of a shampoo with anti-dandruff, oil-control and itching-relieving effects.

4. A shampoo, characterized in that: The shampoo comprises a shampoo composition, which comprises 0.1 to 2 parts of salicylic acid, 0.01 to 1.2 parts of capryloyl glycine and 0.04 to 2 parts of glyceryl laurate based on 100 parts by weight of the shampoo.

5. The shampoo according to claim 4, characterized in that Based on 100 parts by weight of the shampoo, the shampoo composition comprises 0.2 to 2 parts of salicylic acid, 0.02 to 1.2 parts of capryloyl glycine and 0.05 to 2 parts of glyceryl laurate; Optionally, based on 100 parts by weight of the shampoo, the shampoo composition comprises 0.2 to 2 parts of salicylic acid, 0.02 to 1 part of capryloyl glycine and 0.05 to 1.5 parts of glyceryl laurate; Optionally, based on 100 parts by weight of the shampoo, the shampoo composition comprises 0.3 to 1.5 parts of salicylic acid, 0.05 to 0.5 parts of capryloyl glycine and 0.1 to 1 part of glyceryl laurate.

6. The shampoo according to any one of claims 4 to 5, characterized in that The shampoo further comprises at least one of anionic surfactant, nonionic surfactant and zwitterionic surfactant; Optionally, the shampoo further comprises one or more of a cationic conditioning agent, a thickener and a pH adjuster.

7. The shampoo according to claim 6, characterized in that Based on 100 parts by weight of the shampoo, the weight of the anionic surfactant contained in the shampoo is 0-15 parts, and can be 6-15 parts; and / or The anionic surfactant includes one or more of sodium lauryl sulfate, ammonium lauryl sulfate, sodium laureth sulfate and ammonium laureth sulfate.

8. The shampoo according to claim 6, characterized in that Based on 100 parts by weight of the shampoo, the weight of the nonionic surfactant contained in the shampoo is 0-2 parts, and can be optionally 0.5 parts to 2 parts; and / or The nonionic surfactant includes one or more of decyl glucoside, octyl / decyl glucoside, lauryl glucoside and coconut glucoside.

9. The shampoo according to claim 6, characterized in that Based on 100 parts by weight of the shampoo, the weight of the zwitterionic surfactant contained in the shampoo is 0-8 parts, optionally 1.5 parts to 8 parts; and / or The zwitterionic surfactant includes one or more of cocamidopropyl betaine, lauryl hydroxysulfonate and sodium lauroamphoacetate.

10. The shampoo according to claim 6, characterized in that Based on 100 parts by weight of the shampoo, the weight of the cationic conditioning agent contained in the shampoo is 0-1 part, and can be optionally 0.1 part to 1 part; and / or The cationic conditioning agent includes one or more of behentrimonium chloride, stearamidopropyl dimethylamine, guar hydroxypropyltrimonium chloride, polyquaternium-7, polyquaternium-10, polyquaternium-11, polyquaternium-22, and polyquaternium-67.

11. The shampoo according to claim 6, characterized in that Based on 100 parts by weight of the shampoo, the weight of the thickener contained in the shampoo is 0-3 parts, and can be optionally 0.1 parts to 3 parts; and / or The thickener includes one or more of cocamide MEA, cocamide methyl MEA and PEG-150 distearate.

12. The shampoo according to claim 6, characterized in that The pH adjuster comprises one or more of citric acid, sodium citrate and sodium hydroxide; and / or The pH regulator is used in an amount such that the pH value of the shampoo reaches 5-7; Optionally, based on 100 parts by weight of the shampoo, the weight of the pH regulator contained in the shampoo is 0-3 parts, optionally 0.01 parts to 3 parts.

13. The shampoo according to claim 6, characterized in that Taking the weight parts of the shampoo as 100 parts, the shampoo comprises: 0.2-2 parts of salicylic acid, 0.02-1 parts of capryloyl glycine, 0.05-1.5 parts of glyceryl laurate, 6-15 parts of the anionic surfactant, 0.5-2 parts of the nonionic surfactant, 1.5-8 parts of the zwitterionic surfactant, 0.1-1 parts of the cationic conditioning agent, 0.1-3 parts of the thickener and 0.01-3 parts of the pH adjuster.

14. The shampoo according to any one of claims 7 to 13, characterized in that The shampoo also includes water.

15. The shampoo according to any one of claims 4 to 5 and 7 to 13, characterized in that The pH value of the shampoo is 5-7.

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