Preparation method of Western Huang pill for treating endometrial cancer

Abstract

The invention relates to a preparation method of a Western Huang pill for treating endometrial cancer, which comprises the following steps: steaming glutinous millet, and drying to prepare cooked glutinous millet; effective components of the Western Huang pills and the cooked glutinous millet are mixed and smashed, Western Huang pill powder is prepared, and the effective components of the Western Huang pills comprise bezoar or bezoar cultivated in vitro, musk or artificial musk, vinegar-processed frankincense and vinegar-processed myrrh; mixing the Western Huang pill medicinal powder with water according to a mass ratio of 1: (0.1-0.4) for 1-5 minutes to prepare wet powder; refining the wet powder for 2-5 times to prepare a soft material; and taking absolute ethyl alcohol or an ethanol water solution as a lubricant, and pelleting the soft material. The preparation method of the Western Huang pill for treating endometrial cancer is more stable and feasible in process quality, low in microbial pollution risk and capable of effectively improving the medicine quality.

Description

Technical Field

[0001] The present application relates to the technical field of traditional Chinese medicine preparations, and in particular to a method for preparing Xihuang Pills for treating endometrial cancer. Background Art

[0002] Xihuang Pills, also known as Xihuang Pills, were first published in the Complete Collection of Surgical Symptoms and Treatments by Wang Hongxu, a famous doctor in the Qing Dynasty. They are composed of bezoar or in vitro cultivated bezoar, musk or artificial musk, vinegar frankincense, and vinegar myrrh. They are now included in the 2020 edition of the Chinese Pharmacopoeia. They are a famous traditional Chinese medicine anti-cancer prescription with the effects of dissolving hard masses, detoxifying and dispersing carbuncles, reducing swelling and relieving pain. Literature reports that they can be used to treat endometrial cancer. Traditional Xihuang Pills are prepared by the pan-making method: the four medicinal materials in the Xihuang Pills prescription are made into fine powder, and rice paste is used as a binder. The powder and binder are added alternately, and the pills are pan-made and sieved many times to the specified pill specifications to make paste pills.

[0003] However, the operation process of the pan-making method is mostly based on experience, and there is no clear control standard for the process technical parameters. It is relatively random and it is easy to have unstable process quality. It is impossible to implement unified and standardized process technical standard operating procedures, making it difficult to achieve large-scale and automated production. The pan-making method is used for multiple and repeated production methods, which has a low one-time forming rate, low production efficiency, and high dust, which is not conducive to the labor protection of workers.

[0004] There is a method to provide an improved preparation process of Xihuang Pills, wherein the yellow rice is steamed, dried and crushed, and then mixed with vinegar myrrh, vinegar frankincense, yellow rice frozen powder, and bezoar and musk powder, and put into a high-speed multifunctional grinder for rapid and sufficient mixing at -12℃~-8℃, and water is added in time to prepare the soft material, and the soft material is awakened to make pills. Compared with the pan-making method, the preparation process of Xihuang Pills can simplify the process and greatly improve the uniformity after mixing. However, multiple steps in the process need to be carried out under low temperature conditions, which has high requirements for equipment. When carried out at room temperature, it is easy to have problems such as wet powder absorbing moisture and agglomerating, sticking to the machine, and the soft material is too soft and too sticky, and it cannot be smoothly made into pills, which makes the process quality unstable and the risk of microbial contamination high. Summary of the invention

[0005] Based on this, the present application provides a method for preparing Xihuang Pills for treating endometrial cancer, which has more stable and feasible process quality, low risk of microbial contamination, and can effectively improve the quality of the drug.

[0006] A method for preparing Xihuang Pills for treating endometrial cancer comprises the following steps:

[0007] The yellow rice is steamed and then dried to prepare cooked yellow rice;

[0008] The effective components of Xihuang Pills are mixed with the cooked yellow rice, and then crushed to prepare Xihuang Pills powder, wherein the effective components of Xihuang Pills include bezoar, in vitro cultured bezoar or cultivated bezoar, musk or artificial musk, vinegar frankincense and vinegar myrrh;

[0009] The Xihuang Pill powder and water are mixed in a mass ratio of 1: (0.1-0.4) for 1-5 minutes to prepare a wet powder;

[0010] Refining the wet powder 2 to 5 times to make a soft material;

[0011] The soft material is made into pellets using anhydrous ethanol or ethanol aqueous solution as a lubricant.

[0012] In one of the embodiments, during the preparation of wet powder, the Xihuang Pill powder and water are in a mass ratio of 1:(0.15-0.35).

[0013] In one embodiment, during the preparation of the wet powder, the mixing time is 1 min to 3 min.

[0014] In one embodiment, during the pill making process, the volume concentration of the ethanol aqueous solution is 90% to 99.9%.

[0015] In one embodiment, during the pill making process, the volume concentration of the ethanol aqueous solution is 94% to 96%.

[0016] In one embodiment, during the preparation of cooked yellow rice, the moisture content of the cooked yellow rice after drying is ≤5.0%.

[0017] In one embodiment, after the soft material is made, it is proofed at room temperature for 8h to 24h.

[0018] In one embodiment, in the preparation method, the yellow rice is 300 to 600 parts, the bezoar, in vitro cultured bezoar or cultivated bezoar is 10 to 30 parts, the musk or artificial musk is 10 to 30 parts, the vinegar frankincense is 700 to 900 parts, and the vinegar myrrh is 700 to 900 parts.

[0019] In one embodiment, the medicine refining is mechanical medicine refining to produce soft materials.

[0020] In one embodiment, the pelleting is mechanical pelleting.

[0021] The preparation method of the Xihuang Pills for treating endometrial cancer can complete the mechanical pilling of the Xihuang Pills at room temperature by first mixing and then crushing the effective components of the cooked yellow rice Xihuang Pills, and controlling the amount of water and mixing time for preparing the wet powder, the number of times of refining the soft material, and the use of a suitable lubricant in the pilling process. Through the setting and control of specific process parameters, one-time pilling is carried out, forming standardized and normalized pilling process technical conditions, avoiding the differences in manual operation, and making the process quality more stable and feasible, ensuring the appearance, dissolution time and quality uniformity of the paste pill products, while reducing microbial risks, greatly improving production efficiency, shortening the production process cycle, reducing losses, and increasing the yield of finished products, which is conducive to the large-scale, mechanized and continuous production of Xihuang Pills.

[0022] Furthermore, the preparation method of the Xihuang Pills for treating endometrial cancer can prepare wet powder by adding water and medicine powder at one time in a closed mixer, and then refining it into soft material and making pills. The pills have a high one-time forming rate and high production efficiency, and the production process basically does not generate dust, which is beneficial to the labor protection of workers. DETAILED DESCRIPTION

[0023] The preparation method of Xihuang Pills for treating endometrial cancer of the present application is further described in detail below in conjunction with specific examples. The present application can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the understanding of the disclosure of the present application more thorough and comprehensive.

[0024] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art to which this application belongs. The terms used herein in the specification of this application are only for the purpose of describing specific embodiments and are not intended to limit this application.

[0025] In the present application, the technical features described in an open manner include closed technical solutions composed of the listed features, and also include open technical solutions containing the listed features.

[0026] In this application, when it comes to numerical ranges, unless otherwise specified, the above numerical ranges are deemed to be continuous and include the minimum and maximum values ​​of the range, as well as each value between such minimum and maximum values. Further, when a range refers to an integer, each integer between the minimum and maximum values ​​of the range is included. In addition, when multiple ranges are provided to describe features or characteristics, the ranges can be merged. In other words, unless otherwise specified, all ranges disclosed herein should be understood to include any and all subranges included therein.

[0027] The percentage contents involved in this application, unless otherwise specified, refer to mass percentage for solid-liquid mixing and solid-solid mixing, and refer to volume percentage for liquid-liquid mixing.

[0028] The percentage concentrations mentioned in this application, unless otherwise specified, refer to the final concentration, which refers to the percentage of the added component in the system after the addition of the component.

[0029] The temperature parameters in this application, unless otherwise specified, allow for both constant temperature treatment and treatment within a certain temperature range. The constant temperature treatment allows the temperature to fluctuate within the accuracy range of instrument control.

[0030] Normal temperature in this application generally refers to 4°C~30°C, preferably refers to 20±5°C.

[0031] Some examples of the present application provide a method for preparing Xihuang Pills for treating endometrial cancer, comprising the following steps:

[0032] The yellow rice is steamed and then dried to prepare cooked yellow rice;

[0033] The effective components of Xihuang Pills are mixed with the cooked yellow rice, and then crushed to prepare Xihuang Pills powder, wherein the effective components of Xihuang Pills include bezoar, in vitro cultured bezoar or cultivated bezoar, musk or artificial musk, vinegar frankincense and vinegar myrrh;

[0034] The Xihuang Pill powder and water are mixed in a mass ratio of 1: (0.1-0.4) for 1-5 minutes to prepare a wet powder;

[0035] Refining the wet powder 2 to 5 times to make a soft material;

[0036] The soft material is made into pellets using anhydrous ethanol or ethanol aqueous solution as a lubricant.

[0037] Specifically, in the process of preparing cooked yellow rice, the moisture content of the cooked yellow rice after drying is controlled to be ≤5.0%, which is conducive to the control of the conditions of the subsequent process and improves the continuity of the process. In addition, without limitation, the conditions for steaming the yellow rice can be carried out according to the traditional methods in the art.

[0038] Specifically, in the process of preparing Xihuang Pills powder, each component can be configured according to the national pharmaceutical standards for Xihuang Pills.

[0039] In some specific examples, in the preparation method, the yellow rice is 300 to 600 parts by weight, the bezoar, in vitro cultured bezoar or cultivated bezoar is 10 to 30 parts, the musk or artificial musk is 10 to 30 parts, the vinegar frankincense is 700 to 900 parts, and the vinegar myrrh is 700 to 900 parts. Further, in the preparation method, the yellow rice is 500 to 550 parts by weight, the bezoar, in vitro cultured bezoar or cultivated bezoar is 20 to 25 parts, the musk or artificial musk is 20 to 25 parts, the vinegar frankincense is 800 to 850 parts, and the vinegar myrrh is 800 to 850 parts. Specifically, in the preparation method, in parts by weight, the yellow rice is 525 parts, the bezoar, in vitro cultured bezoar or cultivated bezoar is 22.5 parts, the musk or artificial musk is 22.5 parts, the vinegar frankincense is 825 parts, and the vinegar myrrh is 825 parts.

[0040] Specifically, during the preparation of wet powder:

[0041] The mass ratio of the Xihuang Pill powder to water includes but is not limited to: 1:0.1, 1:0.13, 1:0.15, 1:0.17, 1:0.2, 1:0.25, 1:0.27, 1:0.3, 1:0.34, 1:0.35, 0.4 or a range between any two of the foregoing. Further, the mass ratio of the Xihuang Pill powder to water is 1:(0.15-0.35).

[0042] The mixing time includes, but is not limited to, 1 min, 1.5 min, 2 min, 2.5 min, 3 min, 3.5 min, 4 min, 4.5 min, 5 min, or a range between any two of the foregoing. Further, the mixing time is 1 min to 3 min.

[0043] It can be understood that in the process of preparing wet powder, water acts as a binder, inducing stickiness through its contact with the steamed, dried and crushed yellow rice flour, thereby achieving the effect of a paste pill matrix.

[0044] Without limitation, mixing may be performed in a tank mixer.

[0045] Specifically, during the process of making soft materials:

[0046] The number of times of refining medicine includes but is not limited to: 2 times, 3 times, 4 times, 5 times or a range between any two of the above.

[0047] In some examples, after the soft material is made, a step of proofing at room temperature for 8 hours to 24 hours is also included. The proofing time includes but is not limited to: 8 hours, 10 hours, 15 hours, 18 hours, 20 hours, 24 hours or a range between any two of the foregoing. It can be understood that "proofing" can be performed by storing at room temperature.

[0048] In some of the examples, the medicine refining is mechanical refining to make soft materials. The use of mechanical refining to make soft materials avoids manual contact with the medicine and dust, which is beneficial to the labor protection of workers. At the same time, it eliminates the possible contamination of the medicine during manual operation. By refining and controlling parameters such as the number of refining times and storage conditions, it ensures that the dissolution time limit and microbial quantity of Xihuang Pills meet the requirements and improves product quality.

[0049] Specifically, during the process of making soft materials:

[0050] In some examples, the volume concentration of the ethanol aqueous solution is 90% to 99.9%. Specifically, the volume concentration of the ethanol aqueous solution includes but is not limited to 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, 99.9% or a range between any two of the foregoing. Further, the volume concentration of the ethanol aqueous solution is 94% to 96%.

[0051] In some of these examples, the pill making is mechanical pill making, which uses a pilling nozzle and a pill making knife of a certain specification to make pills of the required size.

[0052] For experimental parameters not specified in the following specific embodiments, reference is made to the instructions given in the present application document, and reference may also be made to experimental manuals in the art or other experimental methods known in the art, or to experimental conditions recommended by manufacturers.

[0053] The raw materials and reagents involved in the following specific examples can be obtained from commercial sources, or can be prepared by those skilled in the art according to known methods.

[0054] Example 1

[0055] This embodiment is a method for preparing Xihuang Pills for treating endometrial cancer, Xihuang Pills A00003M batch:

[0056] (1) Take 0.225kg of bezoar, 0.225kg of artificial musk, 8.25kg of vinegar frankincense, 8.25kg of vinegar myrrh, and 5.25kg of yellow rice;

[0057] (2) Steam the yellow rice and then dry it, and control the moisture content after drying to ≤5.0%;

[0058] (3) Grind the formulated amounts of bezoar, artificial musk, vinegar frankincense, vinegar myrrh and steamed and dried yellow rice into fine powder (refer to the standard of "fine powder" in the pharmacopoeia);

[0059] (4) Add purified water at a weight ratio of 1:0.25 and mix in a tank mixer for 1 minute;

[0060] (5) Take the mixed wet powder and put it into a pill making machine for 4 times to make a soft material, and store it at room temperature for 10 hours;

[0061] (6) The soft material is made into pills of the required size through a stripping nozzle and a pill-making knife, and a 95% volume concentration ethanol aqueous solution is used as a lubricant.

[0062] The quality test of the pills prepared in this example is shown in Table 1 below:

[0063] Table 1 Quality statistics of Xihuang Pills of batch A00003M

[0064]

[0065] Example 2

[0066] This embodiment is a method for preparing Xihuang Pills for treating endometrial cancer, Xihuang Pills A00004M batch:

[0067] (1) Take 0.225kg of bezoar, 0.225kg of artificial musk, 8.25kg of vinegar frankincense, 8.25kg of vinegar myrrh, and 5.25kg of yellow rice;

[0068] (2) Steam the yellow rice and then dry it, and control the moisture content after drying to ≤5.0%;

[0069] (3) Grinding the formulated amounts of bezoar, artificial musk, vinegar frankincense, vinegar myrrh and steamed and dried yellow rice into fine powder;

[0070] (4) Add purified water at a weight ratio of 1:0.25 and mix in a tank mixer for 1 minute;

[0071] (5) Take the mixed wet powder and put it into a pill making machine for 4 times to make a soft material, and store it at room temperature for 10 hours;

[0072] (6) The soft material is made into pills of the required size through a stripping nozzle and a pill-making knife, and a 95% volume concentration ethanol aqueous solution is used as a lubricant.

[0073] The quality test of the pills prepared in this example is shown in Table 2 below:

[0074] Table 2 Quality statistics of Xihuang Pills of batch A00004M

[0075]

[0076] Example 3

[0077] This embodiment is a method for preparing Xihuang Pills for treating endometrial cancer, Xihuang Pills B00001M batch:

[0078] (1) Take 0.225kg of bezoar, 0.225kg of artificial musk, 8.25kg of vinegar frankincense, 8.25kg of vinegar myrrh, and 5.25kg of yellow rice;

[0079] (2) Steam the yellow rice and then dry it, and control the moisture content after drying to ≤5.0%;

[0080] (3) Grinding the formulated amounts of bezoar, artificial musk, vinegar frankincense, vinegar myrrh and steamed and dried yellow rice into fine powder;

[0081] (4) Add purified water at a weight ratio of 1:0.25 and mix in a tank mixer for 1 minute;

[0082] (5) Take the mixed wet powder and put it into a pill making machine for 4 times to make a soft material, and store it at room temperature for 10 hours;

[0083] (6) The soft material is made into pills of the required size through a stripping nozzle and a pill-making knife, and a 95% volume concentration ethanol aqueous solution is used as a lubricant.

[0084] The quality test of the pills prepared in this example is shown in Table 3 below:

[0085] Table 3 Quality statistics of Xihuang Pills of B00001M batch

[0086]

[0087] Based on Examples 1 to 3, it can be seen that in the production process of different batches of Xihuang Pill Paste Pills, good appearance, pill weight and dissolution time can be achieved, the pill quality is stable, and the microbial risk is low.

[0088] Investigation Example 1

[0089] This investigation example is an investigation test on the amount of purified water added.

[0090] Take the same batch of Xihuang Pills mixed powder (according to steps (1) to (3) of Example 1), add purified water in different proportions, mix in a tank mixer for 3 minutes, and then put the mixed wet powder into a pill making machine for 5 times, store it at room temperature for 24 hours, and make pills through a stripping nozzle and a pill making knife, using a 95% volume concentration ethanol aqueous solution as a lubricant. Check the appearance, pill weight, and dissolution time of the wet pills. The results are shown in Table 4 below:

[0091] Table 4

[0092]

[0093] In the single factor test of the ratio of Xihuang Pills powder to purified water, different water addition gradients were set, and the pill appearance, pill weight, and dissolution time were used as evaluation indicators. The results showed that when the powder: purified water mass ratio was set to 1:0.08, the pill appearance, pill weight, and dissolution time did not meet the requirements; when the powder: purified water mass ratio was set to 1:0.45, the pill appearance and pill weight did not meet the requirements; when the powder: purified water mass ratio was set to 1:0.13, 1:0.17, 1:0.25, 1:0.27, and 1:0.34, the pill quality after pill making met the requirements. Combined with the actual production, in order to facilitate production operation and dosage calculation, the weight ratio of powder to purified water in Xihuang Pills was clearly defined as 1:(0.1~0.4).

[0094] Investigation Example 2

[0095] This investigation example is an investigation test of the mixing time of a tank mixer.

[0096] Take the same batch of Xihuang Pills mixed with powder (according to steps (1) to (3) of Example 1), add purified water at a weight ratio of powder: purified water = 1:0.25, take samples after mixing for 1 minute, 3 minutes, 5 minutes, and 6 minutes to observe the appearance of the mixed wet powder, put the mixed wet powder into a pill making machine for 5 times, store it at room temperature for 24 hours, and make pills through a strip outlet and a pill making knife, using a volume concentration of 95% ethanol aqueous solution as a lubricant. Investigate the refining and pill making conditions. The results are shown in Table 5 below:

[0097] Table 5

[0098]

[0099] In the single factor investigation test of the mixing time of Xihuang Pills using a slot mixer, different mixing time gradients were set, and the appearance of the mixed wet powder, drug refining, and pill making were used as evaluation indicators. The results showed that the appearance quality of the mixed wet powder was uneven when mixed for 0.5 minutes, and too many refining times caused the soft material to harden, making it impossible to make pills continuously, and the appearance quality of the pills was unqualified; the appearance of the mixed wet powder was uniform when mixed for 1 minute, 3 minutes, and 5 minutes, and the drug refining and pill making were smooth and stable; when mixed for 6 minutes, the mixed wet powder formed large lumps due to moisture absorption, which was not conducive to the subsequent drug refining and pill production, and the appearance and weight of the pills did not meet the regulations. Therefore, the mixing time of Xihuang Pills when using a slot mixer is clearly defined as 1 to 5 minutes.

[0100] Investigation Example 3

[0101] This investigation example is an investigation test on the number of times of refining medicine.

[0102] Take the same batch of Xihuang Pills mixed with powder (according to steps (1) to (3) of Example 1), add purified water at a ratio of powder: purified water = 1:0.13, mix in a tank mixer for 5 minutes, refine the medicine 1, 2, 3, 5, and 8 times respectively, store at room temperature for 24 hours, and make pills through a stripping nozzle and a pill making knife, using a volume concentration of 95% ethanol aqueous solution as a lubricant. Samples were taken to investigate the appearance, pill weight, and wet pill dissolution. The results are shown in Table 6 below:

[0103] Table 6

[0104]

[0105] In the single factor investigation test of the number of times of refining Xihuang Pills, different gradients of the number of refining times were set, and the pill appearance, pill weight, and dissolution time were used as evaluation indicators. The results showed that when the medicine was refined once, the soft material could not be refined evenly, the hardness was large, and the pills could not be made smoothly; when the medicine was refined eight times, the soft material was too soft and too sticky, and the pills could not be made smoothly; when the medicine was refined two, three, and five times, the quality of the prepared pills met the requirements. Combined with the actual production, the number of times of refining when making Xihuang Pills was clearly defined as 2 to 5 times.

[0106] Investigation Example 4

[0107] This investigation example is an investigation test on the proofing conditions of soft materials.

[0108] The same Xihuang Pill soft material (according to steps (1) to (5) of Example 1) was taken and placed at room temperature for 4 h, 8 h, 12 h, 24 h, and 28 h, respectively, and pelletized by a stripping nozzle and a pelletizing knife, using a 95% volume concentration ethanol aqueous solution as a lubricant. Samples were taken to investigate the texture of the soft material and the appearance, pill weight, and wet pill dissolution of the obtained pills. The results are shown in Table 7 below:

[0109] Table 7

[0110]

[0111] In the test of the storage conditions of Xihuang Pills soft material, when placed at room temperature for 4 hours, the soft material was too soft, sticking to the knife during pill making, and the appearance and weight of the pills did not meet the regulations; when placed at room temperature for 30 hours, the soft material became hard and could not be directly made into pills, and it was necessary to re-refine the pills, and the appearance and weight of the pills did not meet the regulations; when placed at room temperature for 8 hours to 24 hours, the soft material was moderately hard and soft, and the appearance, weight, and dissolution time of the pills all met the regulations. Combined with actual production, the storage conditions of Xihuang Pills soft material are clearly defined as 8 hours to 24 hours at room temperature.

[0112] Investigation Example 5

[0113] This investigation example is an investigation test of lubricants during pill making.

[0114] The same Xihuang Pill soft material (according to steps (1) to (5) of Example 1) was taken, and after installing the stripping nozzle and the pill making knife, pill making was performed without lubricant, with purified water, 95% ethanol aqueous solution (95% ethanol) and anhydrous ethanol as lubricants. Samples were taken to investigate the pill making situation, pill appearance and pill weight. The results are shown in Table 8 below:

[0115] Table 8

[0116]

[0117] In the screening test of lubricants, the pills were sticky when there was no lubricant and when purified water was used as lubricant. The appearance quality of the pills did not meet the requirements. When 95% ethanol or anhydrous ethanol was used as lubricant, the pills were made smoothly without sticking. The appearance and weight of the pills met the quality standard requirements. In combination with production practice and operational safety, the lubricant for Xihuang Pills was clearly defined as 95% ethanol.

[0118] The technical features of the above-described embodiments may be arbitrarily combined. To make the description concise, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0119] The above-described embodiments only express several implementation methods of the present application, which is convenient for understanding the technical solution of the present application in detail, but it cannot be understood as limiting the scope of protection of the patent application. It should be pointed out that for ordinary technicians in this field, without departing from the concept of the present application, several modifications and improvements can be made, which all belong to the scope of protection of the present application. It should be understood that the technical solutions obtained by those skilled in the art through logical analysis, reasoning or limited experiments on the basis of the technical solutions provided in the present application are all within the scope of protection of the claims attached to the present application. Therefore, the scope of protection of the patent of this application shall be based on the content of the attached claims, and the description can be used to interpret the content of the claims.

Claims

1. A method for preparing Xihuang Pills for treating endometrial cancer, characterized in that: The steps include: The yellow rice is steamed and then dried to prepare cooked yellow rice; The effective components of Xihuang Pills are mixed with the cooked yellow rice, and then crushed to prepare Xihuang Pills powder, wherein the effective components of Xihuang Pills include bezoar, in vitro cultured bezoar or cultivated bezoar, musk or artificial musk, vinegar frankincense and vinegar myrrh; The Xihuang Pill powder and water are mixed in a mass ratio of 1:(0.1-0.4) for 1 min-5 min to prepare a wet powder; Refining the wet powder 2 to 5 times to make a soft material; The soft material is made into pellets using anhydrous ethanol or ethanol aqueous solution as a lubricant.

2. The method for preparing Xihuang Pills for treating endometrial cancer according to claim 1, characterized in that: In the process of preparing wet powder, the Xihuang Pill powder and water are mixed in a mass ratio of 1:(0.15~0.35).

3. The method for preparing Xihuang Pills for treating endometrial cancer according to claim 1, characterized in that: In the process of preparing wet powder, the mixing time is 1min~3min.

4. The method for preparing Xihuang Pills for treating endometrial cancer according to claim 1, characterized in that: During the pill making process, the volume concentration of the ethanol aqueous solution is 90% to 99.9%.

5. The method for preparing Xihuang Pills for treating endometrial cancer according to claim 4, characterized in that: During the pill making process, the volume concentration of the ethanol aqueous solution is 94% to 96%.

6. The method for preparing Xihuang Pills for treating endometrial cancer according to claim 1, characterized in that: During the preparation of cooked yellow rice, the moisture content of the cooked yellow rice after drying is ≤5.0%.

7. The method for preparing Xihuang Pills for treating endometrial cancer according to claim 1, characterized in that: After the soft material is made, it is proofed at room temperature for 8h~24h.

8. The method for preparing Xihuang Pills for treating endometrial cancer according to any one of claims 1 to 7, characterized in that: In the preparation method, in parts by weight, the yellow rice is 300 to 600 parts, the bezoar, in vitro cultured bezoar or cultivated bezoar is 10 to 30 parts, the musk or artificial musk is 10 to 30 parts, the vinegar frankincense is 700 to 900 parts, and the vinegar myrrh is 700 to 900 parts.

9. The method for preparing Xihuang Pills for treating endometrial cancer according to any one of claims 1 to 7, characterized in that: The medicine refining is a mechanical medicine refining method to produce soft materials.

10. The method for preparing Xihuang Pills for treating endometrial cancer according to any one of claims 1 to 7, characterized in that: The pelleting is mechanical pelleting.

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