A detection kit for judging benign or malignant pulmonary nodules and a method for using the same

Abstract

The present application discloses a detection kit for judging the benign or malignant nature of a lung nodule and a method for using the same, and relates to the field of gene detection technology. The kit comprises a detection kit and a collection tube, wherein a marking protrusion for calibrating a liquid level is fixedly installed in the collection tube, and a plurality of spike cones are installed on the top of the marking protrusion. A plurality of metal strips are slidably connected to an opening at the top of the collection tube, and a flexible curtain is installed between the plurality of metal strips. An annular magnet capable of changing the angle of the metal strips is slidably connected in the collection tube, and the annular magnet can generate a magnetic attraction force on the metal strips. A sealing air bag is fixedly installed at the bottom of the plurality of metal strips, and an elastic membrane is fixedly installed at the bottom of the sealing air bag, and a plurality of filter holes are opened on the elastic membrane. The filter holes on the elastic membrane can preliminarily filter bubbles in saliva to meet the saliva collection demand, thereby ensuring the collection amount of the saliva sample and improving the purity of the saliva sample.

Description

Technical Field

[0001] The present invention relates to the field of gene detection technology, and in particular to a detection kit for judging benign or malignant pulmonary nodules and a method of using the kit. Background Art

[0002] Early detection of tumors mainly relies on imaging examinations, and low-dose spiral CT (LDCT) screening can reduce tumor mortality. However, for uncertain nodules, the risk of malignancy is still difficult to evaluate, and sputum cytology has the highest specificity. Pathologists with rich diagnostic experience can perform genetic testing on patients through saliva to determine whether the patient's lung nodules are benign or malignant.

[0003] In the prior art, a Chinese invention patent with announcement number CN118285851B discloses a kit for early gene detection of lung cancer, including a kit shell, a saliva collecting mechanism for collecting saliva samples installed inside the kit shell, the saliva collecting mechanism including a collecting tube for collecting saliva samples, a protective mechanism for protecting the saliva samples installed outside the saliva collecting mechanism, a plurality of metal strips movably installed inside the collecting tube, and a flexible curtain fixedly installed between adjacent metal strips. During the sealing process of the saliva sample of the device, air bubbles on the top of the saliva and a small amount of saliva are discharged from the edge of the sealing airbag. The sealing airbag is a soft material. When the pressure between the sealing airbag and the collecting tube increases, the air bubbles on the top of the saliva and a small amount of saliva will squeeze the sealing airbag upward, causing its edge position to deform and thus be discharged, thereby reducing the air content in the sealed saliva and reducing the possibility of the saliva sample being contaminated by viruses and bacteria in the air.

[0004] In order to ensure that the amount of saliva collected meets the needs of subsequent testing, the above-mentioned device installs a marking protrusion and a puncture cone for puncturing bubbles in the saliva in the collection tube. However, eliminating bubbles in the saliva only by the puncture cone is not only inefficient, but also because the user may tilt the device when using the above-mentioned device to facilitate saliva collection, which will cause the saliva to be unable to contact the centrally located puncture cone, and the puncture cone will be unable to puncture the bubbles, resulting in a large amount of bubbles in the saliva collected at the bottom of the collection tube, ultimately resulting in the amount of saliva being unable to meet the needs of subsequent testing. Summary of the invention

[0005] The embodiments of the present application solve the technical problem in the prior art that the amount of saliva collected cannot meet the needs of subsequent testing by providing a detection kit for judging the benign or malignant nature of lung nodules and a method of using the same.

[0006] The embodiment of the present application provides a detection kit for judging the benign or malignant nature of a lung nodule, comprising a kit and a collecting tube, wherein the collecting tube is fixedly installed inside the kit, and mutually connected liquid outlets are provided at the bottom of the kit and the collecting tube, a plug is detachably installed in the liquid outlet, a marking protrusion for calibrating the liquid level is also fixedly installed in the collecting tube, a plurality of spike cones are installed on the top of the marking protrusion, a plurality of metal strips are slidably connected to the top opening of the collecting tube, a flexible curtain is installed between the plurality of metal strips, an annular magnet capable of changing the angle of the metal strip is also slidably connected to the collecting tube, and the annular magnet can generate magnetic attraction to the metal strip A sealing airbag is fixedly installed at the bottom of several metal strips, the diameter of the marking protrusion is smaller than the inner diameter of the collecting tube, and the sealing airbag can expand. When the sealing airbag expands and contacts the marking protrusion, the expanded sealing airbag cooperates with the marking protrusion to seal the collecting end of the collecting tube. An elastic membrane is also fixedly installed at the bottom of the sealing airbag, and a plurality of filter holes are opened on the elastic membrane, and the positions of the filter holes correspond to the thorn cone. When the elastic membrane is in a normal pressure state, the diameter of the filter hole is the same as the diameter of the thorn cone. When the sealing airbag expands, it can drive the elastic membrane to stretch, and the diameter of the filter holes on the stretched elastic membrane is larger than the diameter of the thorn cone.

[0007] Furthermore, two groups of air supply components are installed in the test kit, and the two groups of air supply components are respectively located on both sides of the collecting tube, each group of air supply components includes an air supply pipe, a T-rod, a piston and an air supply hose, the air supply pipe is fixedly installed on the inner bottom of the test kit, and the piston is slidably installed inside the air supply pipe, the bottom end of the T-rod is fixedly connected to the piston, and the side end of the T-rod is fixedly connected to the annular magnet after passing through the side wall of the collecting tube, and a sliding groove for the T-rod to slide is also provided on the collecting tube, one end of the air supply hose is connected to the air supply pipe, and the other end of the air supply hose is connected to the sealing air bag after passing through the side wall of the collecting tube, and an air intake check valve is also installed on the air supply pipe; a top cover is movably installed on the top of the test kit, and the bottom end of the top cover is rotatably connected to the top end of the T-rod in the two groups of air supply components, a magnet block 1 is also installed at the bottom of the top cover, and a magnet block 2 attracted to the magnet block 1 is installed at the top of the test kit.

[0008] Furthermore, a rotating block is rotatably mounted on the metal bar, and one end of the rotating block away from the metal bar is slidably connected to the inner wall of the collecting tube, and the inner wall of the collecting tube is provided with a sliding groove for the rotating block to slide.

[0009] Furthermore, an annular capsule is installed in each of the filter holes on the elastic membrane, the outer diameter of the annular capsule is equal to the inner diameter of the filter hole, and the annular capsule is filled with water.

[0010] Furthermore, the annular capsule is also filled with iron powder.

[0011] Furthermore, the thorn cone is made of a permanent magnet, and when the elastic membrane moves down to contact the thorn cone, the iron powder in the annular bag corresponding to the thorn cone can be attracted by the magnetic force of the thorn cone and move toward the thorn cone.

[0012] Furthermore, the amount of iron powder filled in the plurality of annular bags on the elastic membrane gradually decreases from the center to the side of the elastic membrane.

[0013] A method for using a detection kit for judging the benign or malignant nature of a pulmonary nodule, and a matching detection kit for judging the benign or malignant nature of a pulmonary nodule, comprising the following steps:

[0014] S1, device opening: the user moves the top cover upward, which drives the T-bar and the annular magnet upward, and then drives the metal bars to move. As the annular magnet moves, the metal bars move to their maximum moving distance, and then the annular magnet continues to move and drives the metal bars to rotate through magnetic attraction, so that the bottoms of the metal bars are close to each other and the tops are far away from each other, so that the metal bars and the flexible curtain form an inverted cone that is wide at the top and narrow at the bottom, and the device is opened;

[0015] S2, saliva collection: after the user turns on the device, he spits saliva toward the center of the flexible curtain. The saliva moves downward under the influence of gravity, passes through the flexible curtain, the elastic membrane, the marking convex block, and enters the bottom of the collection tube. When the user's saliva is collected and covers the marking convex block, sufficient saliva is collected.

[0016] S3, sealing process: after the user has collected enough saliva, the top plate is pressed to drive the T-bar and the annular magnet to move downward. When the T-bar moves downward, the gas inside the air supply tube can be output to the sealing airbag through the air supply hose. As the top plate moves downward, the sealing airbag gradually expands, and the metal strip and the flexible curtain are reset through the restriction of the collection tube and the downward movement of the annular magnet. When the top plate is pressed to contact the reagent box, the magnetic attraction of the first magnet block and the second magnet block cooperate to fix the top plate and the reagent box, and the sealing airbag that has expanded to be full contacts and squeezes the marking convex block at this time to seal the saliva in the collection tube;

[0017] S4, saliva collection: After the user has sealed the saliva, it is delivered to the operator. When the operator needs to collect the user's saliva, the plug at the bottom of the test kit is removed, the saliva is taken out and tested.

[0018] One or more technical solutions provided in the embodiments of the present application have at least the following technical effects or advantages:

[0019] First, the present invention can preliminarily filter the bubbles in the saliva through the installation of the elastic membrane and the filter holes to meet the saliva collection demand, while reducing the influence of the bubbles on the test results, and when the elastic membrane descends, due to the expansion of the sealing airbag and the resetting of the metal strip, the elastic membrane is stretched by external force, so that the aperture of the filter hole increases, and at this time, the tension of the bubbles attached to the filter hole can be increased, so that the bubbles burst, and when the elastic membrane moves to contact with the marking protrusion, the thorn cones corresponding to the multiple filter holes can also penetrate into the filter holes to puncture some large bubbles, thereby ensuring the collection amount of the saliva sample and improving the purity of the saliva sample, and avoiding the damage of the thorn cone to the elastic membrane caused by the installation of the elastic membrane, and the high-quality saliva sample helps to reduce errors and interferences in the detection process and improve the accuracy and reliability of the detection;

[0020] Secondly, the present invention ensures the stability of the shape of the filter hole through the provision of the annular capsule, so that it can effectively block bubbles while passing saliva, improve the purity and quality of the saliva sample, reduce errors and interferences in the detection process, and improve the accuracy and reliability of the detection; and it also plays a supporting and protective role on the filter hole, preventing elastic fatigue after long-term work, which helps to extend the service life of the filter hole and reduce the replacement cost. The spike cone can also easily pass through the filter hole and the annular capsule on the elastic membrane, making the operation process smoother;

[0021] Thirdly, the present invention fills the annular capsule with iron powder to enhance the supporting rigidity of the annular capsule for the filter hole, so that the shape of the filter hole is more stable, and the filtering efficiency of the saliva sample is further improved. The thorn cone uses magnetic attraction to attract the iron powder in the annular capsule, ensuring that the thorn cone can be smoothly and stably inserted into the filter hole. When the thorn cone contacts the annular capsule, the iron powder in the annular capsule can be pushed to the side of the annular capsule facing the thorn cone under the influence of magnetic force, so that the thorn cone passes through the annular capsule more smoothly, effectively puncturing the bubbles attached to the filter hole, and preventing the thorn cone from shifting and the elastic membrane from being damaged: the magnetic attraction not only ensures the accurate alignment of the thorn cone and the filter hole, but also prevents the thorn cone from shifting during the insertion process, thereby avoiding damage to the elastic membrane, helping to extend the service life of the device and reduce replacement costs;

[0022] Fourthly, the present invention sets the highest iron powder content in the annular capsule that first contacts the thorn cone, and uses the high content of iron powder to provide a stronger magnetic attraction, so that the annular capsule and the thorn cone are accurately aligned, thereby providing a positioning effect for other thorn cones to pass through the corresponding annular capsules, thereby preventing the filter hole from shifting and causing the alignment of the thorn cone and the filter hole to deviate, resulting in component damage, extending the service life of the device, and maintaining the collection effect online after the device is used multiple times. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1It is a schematic diagram of the three-dimensional structure of the present invention;

[0024] Figure 2 is a cross-sectional view of the first working state of the present invention;

[0025] Figure 3 is a cross-sectional view of the second working state of the present invention;

[0026] Figure 4 It is a schematic diagram of the three-dimensional structure of the elastic membrane in the first working state of the present invention;

[0027] Figure 5 is a schematic diagram of the three-dimensional structure of the elastic membrane in the second working state of the present invention;

[0028] Figure 6 is a schematic diagram of the three-dimensional structure of the elastic membrane in the second embodiment of the present invention;

[0029] Figure 7 It is a three-dimensional structural cross-sectional view of the annular capsule of the present invention;

[0030] Figure 8 Schematic diagram of the annular capsule and the spike cone in the third embodiment of the present invention.

[0031] In the figure: 100, reagent box; 110, collecting tube; 111, liquid outlet; 112, plug; 113, marking bump; 114, spike cone; 115, annular magnet; 116, sealing air bag; 120, metal strip; 121, rotating block; 122, flexible curtain; 130, top cover; 140, air supply component; 141, air supply pipe; 142, T-bar; 143, piston; 144, air supply hose; 145, air intake check valve; 200, elastic membrane; 210, filter hole; 220, annular bag. DETAILED DESCRIPTION

[0032] To facilitate the understanding of the present invention, the present application will be described more comprehensively below with reference to the relevant drawings; the drawings show preferred embodiments of the present invention, but the present invention can be implemented in many different forms and is not limited to the embodiments described herein; on the contrary, the purpose of providing these embodiments is to enable a more thorough and comprehensive understanding of the disclosed content of the present invention.

[0033] It should be noted that the terms “vertical”, “horizontal”, “up”, “down”, “left”, “right” and similar expressions used in this document are only for illustrative purposes and do not represent the only implementation method.

[0034] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by technicians in the technical field to which the present invention belongs; the terms used in the specification of the present invention are only for the purpose of describing specific embodiments and are not intended to limit the present invention; the term "and / or" used herein includes any and all combinations of one or more related listed items.

[0035] Embodiment 1: Figure 1-Figure 5 As shown, the embodiment of the present application provides a detection kit for judging the benign or malignant nature of a pulmonary nodule, comprising a kit 100 and a collecting tube 110, wherein the collecting tube 110 is fixedly installed inside the kit 100, and a liquid outlet 111 is provided at the bottom of the kit 100 and the collecting tube 110, and a plug 112 is detachably installed in the liquid outlet 111, and a marking protrusion 113 for calibrating the liquid level is also fixedly installed in the collecting tube 110, and a plurality of spike cones 114 are installed on the top of the marking protrusion 113, and a plurality of metal strips 120 are slidably connected to the top opening of the collecting tube 110, and the plurality of metal strips 120 are slidably connected to the top opening of the collecting tube 110. A flexible curtain 122 is installed between the metal strips 120, and a ring magnet 115 capable of changing the angle of the metal strips 120 is also slidably connected in the collection tube 110. The ring magnet 115 can generate magnetic attraction to the metal strips 120. A sealing airbag 116 is fixedly installed at the bottom of the metal strips 120. The sealing airbag 116 is an annular airbag. The diameter of the marking protrusion 113 is smaller than the inner diameter of the collection tube 110. The sealing airbag 116 can expand. When the sealing airbag 116 expands and contacts the marking protrusion 113, the expanded sealing airbag 116 cooperates with the marking protrusion 113 to seal the collection tube 110. At the end, an elastic membrane 200 is fixedly installed at the bottom of the sealing airbag 116, and a plurality of filter holes 210 are opened on the elastic membrane 200, and the positions of the filter holes 210 correspond to the thorn cone 114. When the elastic membrane 200 is under normal pressure, the diameter of the filter holes 210 is the same as the diameter of the thorn cone 114. When the sealing airbag 116 expands, it can drive the elastic membrane 200 to stretch. The diameter of the filter holes 210 on the stretched elastic membrane 200 is larger than the diameter of the thorn cone 114. When the user collects saliva, the filter holes 210 on the elastic membrane 200 can preliminarily filter the bubbles in the saliva to meet the requirements. The saliva collection demand is met, and when the collection is completed, during the descent of the elastic membrane 200, due to the expansion of the sealing airbag 116 and the resetting of the metal strip 120, the elastic membrane 200 is stretched by external force, so that the aperture of the filter hole 210 increases, and at this time, the tension on the bubbles attached to the filter hole 210 can be increased, thereby causing the bubbles to burst, and when the elastic membrane 200 moves to contact the marking protrusion 113, the thorn cones 114 corresponding to the multiple filter holes 210 can also penetrate into the filter holes 210 to puncture some large bubbles, thereby ensuring the collection amount of the saliva sample and improving the purity of the saliva sample.

[0036] Preferably, two groups of air supply components 140 are also installed in the reagent box 100, and the two groups of air supply components 140 are respectively located on both sides of the collection tube 110, and each group of air supply components 140 includes an air supply tube 141, a T-shaped rod 142, a piston 143 and an air supply hose 144. The air supply tube 141 is fixedly installed on the inner bottom of the reagent box 100, and the piston 143 is slidably installed inside the air supply tube 141. The bottom end of the T-shaped rod 142 is fixedly connected to the piston 143, and the side end of the T-shaped rod 142 is fixedly connected to the annular magnet 115 after passing through the side wall of the collection tube 110. A sliding groove for the T-shaped rod 142 to slide is also provided on the collection tube 110. One end of the air supply hose 144 is connected to the air supply tube 141, and the other end of the air supply hose 144 is connected to the sealing airbag 116 after passing through the side wall of the collection tube 110. An air intake check valve 145 is also installed. When the T-bar 142 descends, it can drive the piston 143 to descend, and then output the gas in the air supply pipe 141 to the sealed airbag 116 to control the expansion of the sealed airbag 116. Conversely, when the T-bar 142 moves upward, it can extract gas from the sealed airbag 116, and can also extract gas from the external space through the air intake check valve 145, thereby avoiding the situation where the T-bar 142 cannot move due to excessive negative pressure in the air supply pipe 141. This is a prior art and will not be elaborated on in detail. A top cover 130 is movably installed on the top of the reagent box 100. The bottom end of the top cover 130 is rotatably connected to the top end of the T-bar 142 in the two sets of air supply components 140. A magnet block 1 (not shown in the figure) is also installed at the bottom of the top cover 130, and a magnet block 2 (not shown in the figure) attracted to the magnet block 1 is installed at the top of the reagent box 100.

[0037] Preferably, a rotating block 121 is rotatably mounted on the metal strip 120, and the end of the rotating block 121 away from the metal strip 120 is slidably connected to the inner wall of the collecting tube 110, and a sliding groove for the rotating block 121 to slide is opened on the inner wall of the collecting tube 110. When the annular magnet 115 moves upward, the magnetic attraction between the annular magnet 115 and the metal strip 120 can first drive a plurality of metal strips 120 to move upward along with the annular magnet 115. When the metal strip 120 moves to the point where the rotating block 121 contacts the top of the sliding groove, the annular magnet 115 can no longer drive the metal strip 120 to move upward through the magnetic attraction. However, at this time, the upward formation of the annular magnet 115 is not interrupted. The annular magnet 115 that continues to move upward drives the bottom ends of the plurality of metal strips 120 to approach each other and the top ends to move away from each other through the magnetic attraction, eventually forming an inverted cone that is wide at the top and narrow at the bottom, which is convenient for users to collect saliva. This is a prior art and will not be elaborated on here.

[0038] A method for using a detection kit for judging the benign or malignant nature of a pulmonary nodule, and a matching detection kit for judging the benign or malignant nature of a pulmonary nodule, comprising the following steps:

[0039] S1, device opening: the user moves the top cover 130 upward, and the upward movement of the top cover 130 drives the T-bar 142 and the annular magnet 115 upward, thereby driving the plurality of metal strips 120 to move. As the annular magnet 115 moves, after the metal strips 120 move to their maximum moving distance, the annular magnet 115 continues to move and drives the metal strips 120 to rotate through magnetic attraction, so that the bottoms of the plurality of metal strips 120 are close to each other and the tops are away from each other, so that the plurality of metal strips 120 and the flexible curtain 122 form an inverted cone that is wide at the top and narrow at the bottom, and the device is opened;

[0040] S2, saliva collection: after the user turns on the device, he spits saliva toward the center of the flexible curtain 122. The saliva moves downward under the influence of gravity, passes through the flexible curtain 122, the elastic membrane 200, and the marking convex block 113 in sequence, and then enters the bottom of the collection tube 110 until the user's saliva is collected to cover the marking convex block 113, completing the collection of a sufficient amount of saliva;

[0041] S3, sealing process: after the user has collected enough saliva, the top plate is pressed to drive the T-bar 142 and the annular magnet 115 to move downward. When the T-bar 142 moves downward, the gas in the gas supply tube 141 can be output to the sealing airbag 116 through the gas hose 144. As the top plate moves downward, the sealing airbag 116 gradually expands, and the metal strip 120 and the flexible curtain 122 are reset through the restriction of the collection tube 110 and the downward movement of the annular magnet 115. When the top plate is pressed to contact with the reagent box 100, the magnetic attraction of the magnet block 1 and the magnet block 2 can achieve the fixation of the top plate and the reagent box 100, and the sealing airbag 116 that has expanded to be full contacts and squeezes the marking protrusion 113 at this time, so as to achieve the sealing of the saliva in the collection tube 110;

[0042] S4, saliva collection: After the user has sealed the saliva, it is delivered to the operator. When the operator needs to collect the user's saliva, the plug 112 at the bottom of the reagent kit 100 is removed, the saliva is taken out and tested.

[0043] The technical solutions in the above embodiments of the present application have at least the following technical effects or advantages:

[0044] By installing the elastic membrane 200 and the filter holes 210, the bubbles in the saliva can be initially filtered to meet the saliva collection demand, while reducing the influence of the bubbles on the test results. When the elastic membrane 200 descends, due to the expansion of the sealing airbag 116 and the resetting of the metal strip 120, the elastic membrane 200 is stretched by external force, so that the aperture of the filter holes 210 increases. At this time, the tension on the bubbles attached to the filter holes 210 can be increased, thereby causing the bubbles to burst. When the elastic membrane 200 moves to contact the marking protrusion 113, the thorn cones 114 corresponding to the multiple filter holes 210 can also penetrate into the filter holes 210 to puncture some large bubbles, thereby ensuring the collection amount of the saliva sample and improving the purity of the saliva sample. It also avoids damage to the elastic membrane 200 caused by the thorn cone 114 due to the installation of the elastic membrane 200. High-quality saliva samples help reduce errors and interferences in the detection process and improve the accuracy and reliability of the detection.

[0045] Embodiment 2: Since the device is not a disposable product, it can be used multiple times after professional cleaning and disinfection. In order to avoid elastic fatigue of the elastic membrane 200 after multiple uses, the elastic membrane 200 may be damaged due to collision with the thorn cone 114. Figure 6-Figure 7 As shown, further improvements are made to the first embodiment:

[0046] Preferably, an annular capsule 220 is installed in each of the filter holes 210 on the elastic membrane 200 , the outer diameter of the annular capsule 220 is equal to the inner diameter of the filter hole 210 , and the annular capsule 220 is filled with water.

[0047] The technical solutions in the above embodiments of the present application have at least the following technical effects or advantages:

[0048] The provision of the annular capsule 220 ensures that the shape of the filter hole 210 is stable, so that it can effectively block bubbles while passing saliva, thereby improving the purity and quality of the saliva sample, reducing errors and interferences in the detection process, and improving the accuracy and reliability of the detection; and it also supports and protects the filter hole 210 to prevent elastic fatigue after long-term work, which helps to extend the service life of the filter hole 210 and reduce the replacement cost. The spike 114 can also easily pass through the filter hole 210 and the annular capsule 220 on the elastic membrane 200, making the operation process smoother.

[0049] Embodiment 3: In order to further enhance the supporting effect of the annular capsule 220 on the filter hole 210, as shown in FIG. Figure 8 As shown, further improvements are made to the second embodiment:

[0050] Preferably, the annular bag 220 is also filled with iron powder.

[0051] Preferably, the thorn cone 114 is made of a permanent magnet, and when the elastic membrane 200 moves down to contact the thorn cone 114 , the iron powder in the annular capsule 220 corresponding to the thorn cone 114 can be attracted by the magnetic force of the thorn cone 114 and move toward the thorn cone 114 .

[0052] The technical solutions in the above embodiments of the present application have at least the following technical effects or advantages:

[0053] By filling the annular capsule 220 with iron powder, the supporting rigidity of the annular capsule 220 for the filter hole 210 is enhanced, so that the shape of the filter hole 210 is more stable, and the filtering efficiency of the saliva sample is further improved. The thorn cone 114 uses magnetic attraction to attract the iron powder in the annular capsule 220, ensuring that the thorn cone 114 can be smoothly and stably inserted into the filter hole 210, and when the thorn cone 114 contacts the annular capsule 220, the iron powder in the annular capsule 220 can be pushed to the side of the annular capsule 220 facing the thorn cone 114 under the influence of magnetic force, so that the process of the thorn cone 114 passing through the annular capsule 220 is smoother, and the bubbles attached to the filter hole 210 are effectively punctured, preventing the thorn cone 114 from shifting and the elastic membrane 200 from being damaged: the magnetic attraction not only ensures the accurate alignment of the thorn cone 114 and the filter hole 210, but also prevents the thorn cone 114 from shifting during the insertion process, thereby avoiding damage to the elastic membrane 200, helping to extend the service life of the device and reduce replacement costs.

[0054] Embodiment 4: Since the thorn cone 114 is installed on the marking protrusion 113, and the marking protrusion 113 is in the shape of a boss, when the elastic membrane 200 descends, the thorn cone 114 located at the highest point of the marking protrusion 113 (i.e., the thorn cone 114 at the center of the marking protrusion 113) will first contact the elastic membrane 200. In order to enhance the alignment accuracy of the thorn cone 114 and the annular capsule 220, further improvements are made to Embodiment 3:

[0055] Preferably, the amount of iron powder filled in the plurality of annular bags 220 on the elastic membrane 200 gradually decreases from the center to the side of the elastic membrane 200 .

[0056] The technical solutions in the above embodiments of the present application have at least the following technical effects or advantages:

[0057] By setting the iron powder content in the annular capsule 220 that first contacts the thorn cone 114 to be the highest, and utilizing the high content of iron powder to provide a stronger magnetic attraction, the annular capsule 220 and the thorn cone 114 are accurately aligned, thereby providing a positioning effect for other thorn cones 114 to pass through the corresponding annular capsule 220, thereby preventing the filter hole 210 from shifting and causing damage to components caused by the deviation in the alignment of the thorn cone 114 and the filter hole 210, thereby extending the service life of the device and maintaining the collection effect online after the device is used multiple times.

[0058] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. For those skilled in the art, the present invention may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A detection kit for judging the benign or malignant nature of a pulmonary nodule, comprising a kit (100) and a collecting tube (110), wherein the collecting tube (110) is fixedly installed inside the kit (100), and the bottoms of the kit (100) and the collecting tube (110) are provided with mutually connected liquid outlets (111), a plug (112) is detachably installed inside the liquid outlet (111), a marking protrusion (113) for calibrating the liquid level is also fixedly installed inside the collecting tube (110), a plurality of spike cones (114) are installed on the top of the marking protrusion (113), a plurality of metal strips (120) are slidably connected at the top opening of the collecting tube (110), a flexible curtain (122) is installed between the plurality of metal strips (120), a ring magnet (115) capable of changing the angle of the metal strip (120) is also slidably connected inside the collecting tube (110), and the ring magnet (115) can generate magnetic attraction to the metal strip (120), characterized in that: A sealing airbag (116) is fixedly installed at the bottom of the plurality of metal strips (120); the diameter of the marking protrusion (113) is smaller than the inner diameter of the collecting tube (110); the sealing airbag (116) is expandable; when the sealing airbag (116) expands and contacts the marking protrusion (113), the expanded sealing airbag (116) cooperates with the marking protrusion (113) to seal the collecting end of the collecting tube (110); an elastic membrane (200) is also fixedly installed at the bottom of the sealing airbag (116); a plurality of filtering holes (210) are opened on the elastic membrane (200), and the filtering holes (21 0) corresponds to the thorn cone (114); when the elastic membrane (200) is in a normal pressure state, the diameter of the filter hole (210) is the same as the diameter of the thorn cone (114); when the sealing airbag (116) expands, it can drive the elastic membrane (200) to stretch, and the diameter of the filter hole (210) on the stretched elastic membrane (200) is larger than the diameter of the thorn cone (114); each of the filter holes (210) on the elastic membrane (200) is installed with an annular capsule (220), the outer diameter of the annular capsule (220) is equal to the inner diameter of the filter hole (210), and the annular capsule (220) is filled with water; The annular capsule (220) is also filled with iron powder; The thorn cone (114) is made of a permanent magnet. When the elastic membrane (200) moves down to contact the thorn cone (114), the iron powder in the annular bag (220) corresponding to the thorn cone (114) can be attracted by the magnetic force of the thorn cone (114) and move toward the thorn cone (114).

2. A detection kit for judging the benign or malignant nature of pulmonary nodules according to claim 1, characterized in that: The reagent box (100) is further provided with two groups of gas supply components (140), the two groups of gas supply components (140) being respectively located on both sides of the collecting tube (110), each group of gas supply components (140) comprising a gas supply tube (141), a T-shaped rod (142), a piston (143) and a gas delivery hose (144), the gas supply tube (141) being fixedly installed on the inner bottom of the reagent box (100), the piston (143) being slidably installed inside the gas supply tube (141), the bottom end of the T-shaped rod (142) being fixedly connected to the piston (143), the side end of the T-shaped rod (142) being fixedly connected to the side wall of the collecting tube (110) and then being fixedly connected to the annular magnet (115), the collecting tube (110) being provided with a gas supply tube (141) and a gas supply hose (14 ... The tube (110) is also provided with a slide groove for the T-shaped rod (142) to slide. One end of the gas delivery hose (144) is connected to the gas supply pipe (141). The other end of the gas delivery hose (144) passes through the side wall of the collecting pipe (110) and is connected to the sealing air bag (116). The gas supply pipe (141) is also provided with an air intake check valve (145). A top cover (130) is movably installed on the top of the reagent box (100). The bottom end of the top cover (130) is rotatably connected to the top end of the T-shaped rod (142) in the two groups of gas supply components (140). A magnet block 1 is also installed at the bottom of the top cover (130). A magnet block 2 that attracts the magnet block 1 is installed at the top of the reagent box (100).

3. A detection kit for judging benign or malignant pulmonary nodules according to claim 1, characterized in that: A rotating block (121) is rotatably mounted on the metal bar (120), and one end of the rotating block (121) away from the metal bar (120) is slidably connected to the inner wall of the collecting tube (110), and a sliding groove for the rotating block (121) to slide is provided on the inner wall of the collecting tube (110).

4. A detection kit for judging benign or malignant pulmonary nodules according to claim 1, characterized in that: The amount of iron powder filled in the plurality of annular bags (220) on the elastic membrane (200) gradually decreases from the center to the side of the elastic membrane (200).

5. A method for using a detection kit for judging the benign or malignant nature of a pulmonary nodule, which is used in conjunction with a detection kit for judging the benign or malignant nature of a pulmonary nodule as claimed in any one of claims 1 to 4, characterized in that: The following steps are involved: S1, device opening: the user moves the top cover (130) upward, and the top cover (130) moves upward, driving the T-shaped rod (142) and the annular magnet (115) to move upward, and then driving the plurality of metal strips (120) to move. As the annular magnet (115) moves, the metal strips (120) move to their maximum moving distance, and then the annular magnet (115) continues to move and drives the metal strips (120) to rotate through magnetic attraction, so that the bottoms of the plurality of metal strips (120) are close to each other and the tops are away from each other, so that the plurality of metal strips (120) and the flexible curtain (122) form an inverted cone that is wide at the top and narrow at the bottom, and the device is opened; S2, saliva collection: after turning on the device, the user spits saliva toward the center of the flexible curtain (122), and the saliva moves downward under the influence of gravity, passes through the flexible curtain (122), the elastic membrane (200), the marking convex block (113) in sequence, and then enters the bottom of the collection tube (110), until the user's saliva is collected and covers the marking convex block (113), thus completing the collection of a sufficient amount of saliva; S3, sealing process: after the user has collected a sufficient amount of saliva, the top plate is pressed to drive the T-shaped rod (142) and the annular magnet (115) to move downward. When the T-shaped rod (142) moves downward, the gas inside the gas supply tube (141) can be output to the sealing airbag (116) through the gas supply hose (144). As the top plate moves downward, the sealing airbag (116) gradually expands, and the metal strip (120) and the flexible curtain (122) are reset due to the restriction of the collection tube (110) and the downward movement of the annular magnet (115). When the top plate is pressed to contact the reagent box (100), the magnetic attraction force of the first magnet block and the second magnet block cooperates to fix the top plate and the reagent box (100), and at this time, the sealing airbag (116) that has expanded to be full contacts and squeezes the marking protrusion (113), thereby sealing the saliva in the collection tube (110); S4, saliva collection: After the user has sealed the saliva, it is delivered to the operator. When the operator needs to collect the user's saliva, the plug (112) at the bottom of the test kit (100) is removed, the saliva is taken out and tested.

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