Ablation system and control method thereof

Abstract

The invention relates to an ablation system and a control method thereof. An ablation system includes a catheter. The electrodes are arranged on the catheter at intervals; the output module is respectively connected with the plurality of electrodes and is used for providing an electrical stimulation signal to each electrode, and the electrical stimulation signal is used for activating pulmonary artery sympathetic nerves; the acquisition module is used for acquiring physiological parameters. The control module is connected with the output module and the acquisition module and used for controlling the output module to sequentially provide electrical stimulation signals to the at least one electrode and determining whether a stimulation area corresponding to the current electrode is an ablation area or not according to the physiological parameters under the action of the electrical stimulation signals, and when the physiological parameters provide the electrical stimulation signals for the at least one electrode, the stimulation area corresponding to the current electrode is the ablation area. The at least one electrode acts on physiological parameters of the object. By adopting the system provided by the invention, the accuracy of positioning the ablation area is improved, the accuracy of applying the ablation energy can be improved, and unnecessary damage to the target object due to the wrong application position of the ablation energy is avoided while the ablation effect is ensured.

Description

Technical Field

[0001] The present application relates to the field of medical technology, and in particular to an ablation system and a control method thereof. Background Art

[0002] With the development of medical technology, minimally invasive ablation technology has emerged. By making a small incision in the patient's epidermis, the electrode needle is inserted into the patient's body to reach the location of the patient's lesion tissue, and then the high-voltage pulse generated between the electrodes is used to ablate the patient's lesion tissue, thereby achieving the purpose of removing the patient's lesion tissue. Pulmonary hypertension (PH) refers to a clinical and pathophysiological syndrome caused by changes in pulmonary vascular structure or function due to a variety of heterogeneous diseases (causes) and different pathogenesis, which causes increased pulmonary vascular resistance and pulmonary artery pressure, and then develops into right heart failure or even death. At present, the treatment of pulmonary hypertension revolves around three major pathways related to endothelial dysfunction responsible for pulmonary artery remodeling. This includes inhibiting vasoconstrictors and activating major vasodilators such as nitric oxide and prostacyclin. Despite the widespread use of pulmonary hypertension-specific treatments, the mortality rate of patients remains high, accounting for about 10% of patients each year, and the 5-year survival rate is still unacceptably low (59.4%). Studies have shown that increased sympathetic nerve activity is related to the pathogenesis of pulmonary hypertension. Rudner et al. reported that sympathetic nerves exist in the pulmonary artery wall and participate in the regulation of pulmonary artery pressure, suggesting that perivascular nerves are potential targets for interventional therapy. Therefore, pulmonary artery dialysis (PADN) has been proposed as a method to reduce pulmonary artery pressure. Some people have already practiced this method in animals and humans. In these studies, a decrease in pulmonary artery pressure was recorded after circular ablation of the pulmonary artery bifurcation and the proximal part of the left and right main pulmonary arteries. Published clinical studies have shown that pulmonary artery pressure is significantly reduced after non-selective circular pulmonary artery ablation. Non-selective circular pulmonary artery ablation is blind ablation, which ignores the distribution of sympathetic nerves on the pulmonary artery adventitia, which may further lead to pulmonary artery fibrosis remodeling and loss of pulmonary artery expansion capacity, which is associated with the further development of pulmonary hypertension and death. In response to this problem, some people have proposed that pulmonary artery stimulation mapping of ablation targets may be a safer and more reasonable approach.

[0003] Currently, pulmonary artery ablation for the treatment of pulmonary hypertension is still in the exploratory stage worldwide. Doctors rely on their own experience to operate electrodes to perform ablation surgery on patients' diseased tissues.

[0004] However, since the shape of the diseased tissue in the patient's body is random and irregular, and the location distribution of various tissues in different patients is also different, the ablation surgery using traditional technology is not accurate enough and can easily cause unnecessary damage to the patient. Therefore, how to map the ablation target (the location where the sympathetic nerves exist) in the pulmonary artery to achieve the purpose of precise ablation, thereby reducing damage to the blood vessels and improving the surgical effect, is a problem that needs to be solved at present. Summary of the invention

[0005] Based on this, it is necessary to provide an ablation system and a control method thereof that can accurately find the ablation position and thus perform precise ablation surgery in order to address the above technical issues.

[0006] An ablation system comprises: a catheter; a plurality of electrodes, each of which is arranged on the catheter at intervals; an output module, respectively connected to the plurality of electrodes, and used to provide an electrical stimulation signal to each of the electrodes, wherein the electrical stimulation signal is used to activate the pulmonary artery sympathetic nerves; an acquisition module, used to acquire physiological parameters of the objects acted upon by the plurality of electrodes; a control module, respectively connected to the output module and the acquisition module, and used to control the output module to sequentially provide the electrical stimulation signal to at least one of the electrodes, and to acquire the physiological parameters through the acquisition module, and determine whether the stimulation area corresponding to the current electrode is a recommended ablation area based on the physiological parameters under the action of the electrical stimulation signal.

[0007] In one embodiment, the catheter includes a support portion and an electrode portion, wherein the electrode portion is a flexible hose; and the plurality of electrodes are arranged at intervals on the electrode portion.

[0008] In one embodiment, the control module is used to control the output module to provide the electrical stimulation signal to at least one of the electrodes in sequence according to a preset order.

[0009] In one embodiment, the preset order is from the electrode farthest from the support portion to the electrode closest to the support portion, or the preset order is from the electrode closest to the support portion to the electrode farthest from the support portion.

[0010] In one of the embodiments, the control module is used to control the output module to provide electrical stimulation signals to the electrode pair in sequence according to the preset order; wherein the electrode pair includes two electrodes arranged adjacent to each other.

[0011] In one embodiment, the ablation system also includes an ablation module respectively connected to the multiple electrodes, wherein the control module is further used to determine the ablation electrode group when it is determined that the stimulation area is the recommended ablation area, and control the ablation module to provide an ablation signal to the target electrode, wherein the effective range of each electrode included in the ablation electrode group at least covers the recommended ablation area, and the target electrode is one of the ablation electrode groups.

[0012] In one embodiment, the ablation system further includes: a neutral electrode, connected to the output module and the ablation module respectively; the control module is used to control the output module to conduct a path between at least one of the electrodes and the neutral electrode to establish a stimulation circuit, wherein the output module provides an electrical stimulation signal to at least one of the electrodes through the stimulation circuit.

[0013] In one of the embodiments, the control module is further used to open a path between the target electrode and the neutral electrode to establish an ablation circuit after determining the recommended ablation area, wherein the ablation module provides an ablation signal to the target electrode through the ablation circuit.

[0014] In one embodiment, when the number of electrodes included in the ablation electrode group is multiple, the control module is also used to re-control the output module to provide electrical stimulation signals to the ablation electrode group and obtain the physiological parameters after controlling the ablation module to provide ablation signals to the target electrodes, and when it is determined according to the physiological parameters that the current stimulation area is still the recommended ablation area, control the ablation module to provide ablation signals to the retransmission electrodes, wherein the retransmission electrodes are electrodes in the ablation electrode group that have not been provided with the ablation signals.

[0015] In one embodiment, the physiological parameter includes a blood pressure value; the control module is used to determine that the stimulation area corresponding to at least one of the electrodes is a recommended ablation area when the blood pressure value satisfies a preset blood pressure condition; wherein the preset blood pressure condition includes: the blood pressure value shows a continuous upward trend, and the blood pressure values ​​within a set time period are all greater than a first preset value; or, the blood pressure value first shows a downward trend and then an upward trend, and the blood pressure values ​​within a set time period are all greater than a first preset value; wherein the first preset value is the blood pressure value when the electrical stimulation signal is not applied.

[0016] In one embodiment, the physiological parameter includes a heart rate value; the control module is used to determine that the stimulation area corresponding to at least one of the electrodes is a recommended ablation area when the heart rate value satisfies a preset heart rate condition; wherein the preset heart rate condition includes: the absolute value of the rate of change of the heart rate value relative to a second preset value exceeds a set threshold, wherein the second preset value is the heart rate value when the electrical stimulation signal is not applied.

[0017] In one embodiment, the acquisition module includes: a blood pressure acquisition unit, connected to the control module and an external blood pressure sensor, for obtaining the blood pressure value measured by the blood pressure sensor; and / or a heart rate acquisition unit, connected to the control module and an external heart rate measurement device, for obtaining the heart rate value measured by the heart rate measurement device; the control module is used to determine that the stimulation area corresponding to at least one of the electrodes is a recommended ablation area when the heart rate value meets a preset heart rate condition or the blood pressure value meets a preset blood pressure condition.

[0018] A control method for an ablation system is applied to the aforementioned ablation system, the method comprising: providing electrical stimulation signals to at least one of the electrodes in sequence; in the process of providing the electrical stimulation signals to at least one of the electrodes, obtaining physiological parameters of an object of action of at least one of the electrodes; and determining whether a stimulation area corresponding to the current electrode is a recommended ablation area based on the physiological parameters.

[0019] In one embodiment, the physiological parameters include blood pressure values; determining whether the stimulation area corresponding to the current electrode is a recommended ablation area based on the physiological parameters includes: when the blood pressure value satisfies a preset blood pressure condition, determining that the stimulation area corresponding to at least one of the current electrodes is a recommended ablation area; wherein the preset blood pressure condition includes: the blood pressure value shows a continuous increasing trend, and the blood pressure values ​​within a set time period are all greater than a first preset value; or, the blood pressure value first shows a decreasing trend and then an increasing trend, and the blood pressure values ​​within a set time period are all greater than a first preset value; wherein the first preset value is the blood pressure value when the electrical stimulation signal is not applied.

[0020] In one embodiment, the physiological parameters include a heart rate value; determining whether the stimulation area corresponding to the current electrode is a recommended ablation area based on the physiological parameters includes: when the heart rate value satisfies a preset heart rate condition, determining that the stimulation area corresponding to at least one of the current electrodes is a recommended ablation area; wherein the preset heart rate condition includes: the absolute value of the rate of change of the heart rate value relative to a second preset value exceeds a set threshold, wherein the second preset value is the heart rate value when the electrical stimulation signal is not applied.

[0021] In one of the embodiments, the set threshold is 15%.

[0022] The ablation system and its control method are provided with a catheter including a plurality of electrodes, so as to facilitate the insertion of the catheter into the body of the object, and then the target tissue is treated by the electrodes arranged at intervals on the catheter. By providing an output module connected to the plurality of electrodes respectively, an electrical stimulation signal can be provided to each electrode, and the electrical stimulation signal can activate the pulmonary artery sympathetic nerve, so as to facilitate the subsequent identification of the pulmonary artery sympathetic nerve. By providing an acquisition module, the physiological parameters of the object of action of the plurality of electrodes can be acquired. By providing a control module, the output module can be controlled to sequentially provide an electrical stimulation signal to at least one electrode. Since the electrodes are arranged at intervals on the catheter, the output module sequentially provides an electrical stimulation signal to each electrode, so that each electrode can release the electrical stimulation signal sequentially, thereby sequentially applying the electrical stimulation signal to different positions in the pulmonary artery of the target object, which is convenient for finding the position of the pulmonary artery sympathetic nerve, and in the process of finding the position of the pulmonary artery sympathetic nerve, since the electrodes applying the electrical stimulation signal will be switched sequentially, the catheter does not need to be moved, and the electrical stimulation signal can be applied to different positions in the pulmonary artery of the target object, which can avoid the damage that may be caused to the target object by frequent movement of the catheter. Then, based on the physiological parameters under the action of the electrical stimulation signal, it is determined whether the stimulation area corresponding to the current electrode is the recommended ablation area, so that the position of the pulmonary artery sympathetic nerve, that is, the position of the recommended ablation area, can be accurately found. Since the ablation energy causes great damage to the target object, the system of the present application is used to improve the accuracy of locating the recommended ablation area, which can improve the accuracy of applying the ablation energy, and while ensuring the ablation effect, avoid unnecessary damage to the target object due to the wrong position of applying the ablation energy. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the conventional technology, the drawings required for use in the embodiments or the conventional technology descriptions are briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0024] Figure 1 is a schematic structural diagram of an ablation system in one embodiment;

[0025] Figure 2 is a schematic diagram of the structure of a catheter in one embodiment;

[0026] Figure 3 is a schematic structural diagram of an electrode portion of a catheter in one embodiment;

[0027] Figure 4 is a schematic structural diagram of an ablation system in another embodiment;

[0028] Figure 5 is a structural schematic diagram of an ablation system in yet another embodiment;

[0029] Figure 6 A variation trend diagram of a first category of blood pressure values ​​in one embodiment;

[0030] Figure 7 is a variation trend diagram of the second category of blood pressure values ​​in one embodiment;

[0031] Figure 8 is a flowchart of a work flow of an ablation system in one embodiment;

[0032] Fig. 9 is a variation trend diagram of the fourth category of heart rate values ​​in one embodiment;

[0033] Fig.10 is a change trend diagram of the fifth category of heart rate values ​​in one embodiment;

[0034] Fig.11 is a variation trend diagram of the sixth category of heart rate values ​​in one embodiment;

[0035] Fig.12 is a flowchart of the ablation system in another embodiment;

[0036] Fig.13 is a structural schematic diagram of an ablation system in yet another embodiment;

[0037] Fig.14 is a structural schematic diagram of an ablation system in yet another embodiment;

[0038] Fig.15 is a structural schematic diagram of an ablation system in yet another embodiment;

[0039] Fig.16 FIG. 4 is a flow chart of a method for controlling an ablation system in one embodiment.

[0040] Description of reference numerals:

[0041] 10 - catheter, 20 - electrode, 30 - output module, 40 - control module, 11 - support part, 12 - electrode part, 50 - ablation module, 60 - neutral electrode, 70 - acquisition module, 71 - blood pressure acquisition unit, 72 - heart rate acquisition unit. DETAILED DESCRIPTION

[0042] In order to facilitate understanding of the present application, the present application will be described more fully below with reference to the relevant drawings. Embodiments of the present application are provided in the drawings. However, the present application can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the disclosure of the present application more thorough and comprehensive.

[0043] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art to which this application belongs. The terms used herein in the specification of this application are only for the purpose of describing specific embodiments and are not intended to limit this application.

[0044] It can be understood that the terms "first", "second", etc. used in the present application can be used in this article to describe various elements, but these elements are not limited by these terms. These terms are only used to distinguish the first element from another element.

[0045] Spatially relative terms such as "under," "beneath," "below," "under," "above," "above," and the like may be used herein to describe the relationship of an element or feature shown in the figures to other elements or features. It should be understood that, in addition to the orientations shown in the figures, spatially relative terms also include different orientations of the device in use and operation. For example, if the device in the accompanying drawings is flipped, an element or feature described as "under other elements" or "under it" or "under it" will be oriented as being "above" the other elements or features. Thus, the exemplary terms "under" and "under" may include both upper and lower orientations. In addition, the device may also include additional orientations (e.g., rotated 90 degrees or other orientations), and the spatial descriptors used herein are interpreted accordingly.

[0046] It should be noted that when an element is considered to be "connected" to another element, it can be directly connected to the other element, or connected to the other element through an intermediate element. In addition, the "connection" in the following embodiments should be understood as "electrical connection", "communication connection", etc. if there is transmission of electrical signals or data between the connected objects.

[0047] When used herein, the singular forms "a", "an", and "said / the" may also include plural forms, unless the context clearly indicates otherwise. It should also be understood that the terms "include / comprise" or "have" etc. specify the presence of stated features, wholes, steps, operations, components, parts or combinations thereof, but do not exclude the possibility of the presence or addition of one or more other features, wholes, steps, operations, components, parts or combinations thereof.

[0048] In one embodiment, Figure 1 As shown, an ablation system is provided, comprising: a catheter 10, a plurality of electrodes 20, an output module 30, a control module 40, and a collection module 70, wherein:

[0049] The electrodes 20 are arranged on the catheter 10 at intervals.

[0050] Among them, Figure 2 As shown, the catheter 10 includes a support portion 11 and an electrode portion 12, and the electrode portion 12 is a flexible hose. A plurality of electrodes 20 are arranged at intervals on the electrode portion 12. The support portion 11 can be a sheath of the electrode portion 12, which is used to support the catheter 10 to prevent the catheter 10 from deforming and enable the catheter 10 to smoothly enter the body of the target object, while the electrode portion 12 is a flexible hose that can be bent at will. On the one hand, it avoids stabbing the tissue of the target object, and on the other hand, it is convenient to bend to better cover the area of ​​the target object's tissue that needs to be ablated. The predetermined shape of the electrode portion 12 can be a straight line, a curved shape, a spiral shape, a circular ring shape, etc., without limitation. The electrode 20 is a device that can output energy and can release energy near its setting position to achieve the effect of stimulation or ablation. Each electrode 20 is arranged on the catheter 10 at intervals, so when the catheter 10 is inserted into the body of the target object, the energy released by each electrode 20 can cover different areas. Preferably, the areas covered by the energy released by each electrode 20 do not overlap. For example, the electrode portion 12 can be as follows Figure 3 As shown, the electrode 20 is bent into a ring shape, so that the electrode 20 covers a larger area. Preferably, the electrode portion 12 is placed at the left and right pulmonary artery orifices or the pulmonary artery trunk, and then the pulmonary artery sympathetic nerve is sought.

[0051] The output module 30 is respectively connected to the plurality of electrodes 20 for providing an electrical stimulation signal to each electrode 20 , wherein the electrical stimulation signal is used to activate the pulmonary artery sympathetic nerve.

[0052] Among them, the output module 30 can provide an electrical stimulation signal to each electrode 20. The energy of the electrical stimulation signal is relatively small, usually at the milliampere level. It can be used to electrically stimulate a specific part in the form of a pulse wave. When the stimulation energy acts on a specific part, it will not cause damage to the cells in the specific part, but it will cause changes in the physiological parameters of the target object. Specifically, when the electrical stimulation signal acts on the pulmonary artery sympathetic nerve, the physiological parameters of the target object will change significantly, and when the electrical stimulation signal does not act on the pulmonary artery sympathetic nerve, the change in the physiological parameters of the target object is not obvious.

[0053] Exemplarily, the output module 30 can output a current of 0-30 mA or a voltage of 0-15 V. The output current or voltage can be in the form of pulse energy with a frequency of 0.5-40 Hz and a pulse width of 0.5, 1, or 2 milliseconds.

[0054] The acquisition module 70 is used to acquire physiological parameters of the subject to which the multiple electrodes act.

[0055] The physiological parameter may be heart rate and / or blood pressure.

[0056] The control module 40 is connected to the output module 30 and the acquisition module 70 respectively, and is used to control the output module 30 to provide electrical stimulation signals to at least one electrode 20 in sequence, and to obtain physiological parameters through the acquisition module 70, and to determine whether the stimulation area corresponding to the current electrode 20 is the recommended ablation area based on the physiological parameters under the action of the electrical stimulation signal.

[0057] Specifically, the catheter 10 is provided with a plurality of electrodes 20, and the control module 40 controls the output module 30 to sequentially provide electrical stimulation signals to at least one electrode 20, and then obtains the physiological parameters of the target object. According to the changes in the physiological parameters under the action of the electrical stimulation signal, it can be determined whether the electrical stimulation signal is applied to the pulmonary artery sympathetic nerve, and then it can be determined whether the stimulation area corresponding to the current at least one electrode 20 is the recommended ablation area. By controlling the output module 30 to sequentially provide electrical stimulation signals to different electrodes 20, the position of the pulmonary artery sympathetic nerve can be found and the pulmonary artery sympathetic nerve can be accurately located.

[0058] In this embodiment, by providing a catheter 10 including a plurality of electrodes 20, it is convenient to insert the catheter 10 into the body of the subject, and then treat the target tissue through the electrodes 20 spaced apart on the catheter 10. By providing an output module 30 connected to the plurality of electrodes 20, an electrical stimulation signal can be provided to each electrode 20, and the electrical stimulation signal can activate the pulmonary artery sympathetic nerve, thereby facilitating the subsequent identification of the pulmonary artery sympathetic nerve. By providing a collection module 70, the physiological parameters of the subject of the plurality of electrodes can be collected. By setting up the control module 40, the output module 30 can be controlled to provide electrical stimulation signals to at least one electrode 20 in sequence. Since the electrodes 20 are arranged at intervals on the catheter 10, the output module 30 provides electrical stimulation signals to each electrode 20 in sequence, so that each electrode 20 can release the electrical stimulation signal in sequence, thereby applying the electrical stimulation signal to different positions in the pulmonary artery of the target object in sequence, which is convenient for finding the position of the pulmonary artery sympathetic nerves. In the process of finding the position of the pulmonary artery sympathetic nerves, since the electrodes 20 that apply the electrical stimulation signals will be switched in sequence, the catheter 10 does not need to be moved, and it is possible to apply the electrical stimulation signals to different positions in the pulmonary artery of the target object, which can avoid damage to the target object caused by frequent movement of the catheter 10. Then, based on the physiological parameters under the action of the electrical stimulation signal, it is determined whether the stimulation area corresponding to the current electrode 20 is the recommended ablation area, so that the position of the pulmonary artery sympathetic nerve, that is, the position of the recommended ablation area, can be accurately found. Since the ablation energy causes great damage to the target object, the system of the present application is used to improve the accuracy of locating the recommended ablation area, which can improve the accuracy of applying the ablation energy. While ensuring the ablation effect, it can avoid unnecessary damage to the target object due to the wrong position of applying the ablation energy.

[0059] In one embodiment, the control module is used to control the output module to provide electrical stimulation signals to at least one electrode in sequence according to a preset order.

[0060] The preset sequence may be a sequence set by the doctor according to the needs of the operation, which can sequentially provide electrical stimulation signals to at least one electrode to facilitate the operation or minimize the damage of the electrical stimulation signal to the target object. The preset sequence may be from the electrode farthest from the support to the electrode closest to the support, or the preset sequence may be from the electrode closest to the support to the electrode farthest from the support. The sequence may also be any other form, as long as the electrical stimulation signal is sequentially provided to each electrode until the pulmonary artery sympathetic nerve is located.

[0061] In this embodiment, the control module is used to control the output module to provide electrical stimulation signals to at least one electrode in sequence according to a preset order, thereby providing electrical stimulation signals to each electrode in sequence according to a certain order, so as to find the position of the pulmonary artery sympathetic nerve.

[0062] In one embodiment, the control module is used to control the output module to provide electrical stimulation signals to the electrode pairs in sequence according to a preset order.

[0063] Among them, the electrode pair includes two electrodes arranged adjacent to each other. The control module controls the output module to provide electrical stimulation signals to each two adjacent electrodes in sequence according to a preset order, so that the two adjacent electrodes send electrical stimulation signals each time, which can increase the range of the stimulation area each time, so as to find the position of the pulmonary artery sympathetic nerve more quickly. The electrode pair can also include three electrodes or more electrodes arranged adjacent to each other. The more electrodes the electrode pair includes, the larger the range of the stimulation area each time, and the faster the speed of locating the pulmonary artery sympathetic nerve. However, the more electrodes the electrode pair includes, the lower the accuracy of positioning. It can only be determined that the pulmonary artery sympathetic nerve is in the stimulation area, but the range of the stimulation area is too large, and the specific position of the pulmonary artery sympathetic nerve cannot be determined. The number of electrodes included in the electrode pair can be adjusted as needed to balance the speed and accuracy of locating the pulmonary artery sympathetic nerve.

[0064] In this embodiment, the control module is configured to control the output module to sequentially provide electrical stimulation signals to the electrode pairs in a preset order, thereby enabling the pulmonary artery sympathetic nerves to be located more quickly.

[0065] In one embodiment, Figure 4 As shown, the ablation system further includes an ablation module 50. The ablation module 50 is connected to the plurality of electrodes 20 respectively.

[0066] The ablation module 50 can output an ablation signal, which can be a high-power ablation energy in watts. The high-power ablation energy refers to energy that can cause destructive damage to cells in a specific part and cause them to die when acting on the specific part. For example, the output power of the ablation energy can be 0-40W, which can be adjusted as needed.

[0067] The control module 40 is further configured to determine the ablation electrode group when the stimulation area is determined to be a recommended ablation area, and control the ablation module 50 to provide an ablation signal to the target electrode 20 .

[0068] Among them, the action range of each electrode 20 included in the ablation electrode group at least covers the recommended ablation area, and the target electrode 20 is one of the ablation electrode group. The control module 40 first controls the output module 30 to provide an electrical stimulation signal to at least one electrode 20. In the process of providing the electrical stimulation signal, the control module 40 obtains physiological parameters in real time, and determines whether the stimulation area corresponding to the electrode 20 currently releasing the electrical stimulation signal is the recommended ablation area based on the physiological parameters. If it is determined that the stimulation area corresponding to the electrode 20 currently releasing the electrical stimulation signal is the recommended ablation area, the electrode 20 currently releasing the electrical stimulation signal is determined as the ablation electrode group, indicating that the pulmonary artery sympathetic nerves to be ablated are located in the area covered by the action range of each electrode 20 included in the ablation electrode group. Therefore, the control ablation module 50 provides an ablation signal to the target electrode 20 to facilitate ablation of the pulmonary artery sympathetic nerves.

[0069] In this embodiment, when the stimulation area is determined to be a recommended ablation area, the ablation electrode group is determined, and the ablation module 50 is controlled to provide an ablation signal to the target electrode 20, thereby achieving ablation of the pulmonary artery sympathetic nerves.

[0070] In one embodiment, Figure 5 As shown, the ablation system further includes: a neutral electrode 60. The neutral electrode 60 is connected to the output module 30 and the ablation module 50 respectively. The neutral electrode 60 is one of the electrodes 20 or an electrode independently arranged in other areas of the catheter.

[0071] The neutral electrode 60 may be attached to the skin surface of the target object.

[0072] The control module 40 is used to control the output module 30 to open a path between at least one electrode 20 and the neutral electrode 60 to establish a stimulation circuit.

[0073] The neutral electrode 60 and at least one electrode 20 form a stimulation circuit, and the electrical stimulation signal is released from at least one electrode 20 and conducted to the neutral electrode 60 to form a circuit, so as to stimulate the area between the at least one electrode 20 and the neutral electrode 60 .

[0074] The output module 30 provides an electrical stimulation signal to at least one electrode 20 through a stimulation circuit.

[0075] In this embodiment, by providing a neutral electrode 60, it is convenient to construct a stimulation circuit with at least one electrode 20 to achieve the release of an electrical stimulation signal, thereby facilitating electrical stimulation of the target tissue.

[0076] In one embodiment, the control module is further configured to open a path between the target electrode and the neutral electrode to establish an ablation circuit after determining the recommended ablation area.

[0077] The ablation module provides an ablation signal to the target electrode through an ablation circuit.

[0078] The neutral electrode and at least one electrode form a stimulation circuit, and the ablation signal is released from the at least one electrode and conducted to the neutral electrode to form a circuit, so that the area between the at least one electrode and the neutral electrode can be ablated.

[0079] In this embodiment, an ablation circuit is constructed by a neutral electrode and at least one electrode to release an ablation signal, thereby facilitating ablation of the pulmonary artery sympathetic nerves.

[0080] In one embodiment, when the number of electrodes included in the ablation electrode group is multiple, the control module is also used to re-control the output module to provide electrical stimulation signals to the ablation electrode group and obtain physiological parameters after controlling the ablation module to provide ablation signals to the target electrodes. When it is determined based on the physiological parameters that the current stimulation area is still the recommended ablation area, the control ablation module provides an ablation signal to the retransmission electrode, wherein the retransmission electrode is an electrode in the ablation electrode group that has not been provided with an ablation signal.

[0081] Specifically, when the number of electrodes included in the ablation electrode group is multiple, it can only be determined that the pulmonary artery sympathetic nerve exists in the area covered by the action range of the multiple electrodes, but the target electrode that sends the ablation signal is only one of the electrodes in the ablation electrode group. Therefore, it may happen that the pulmonary artery sympathetic nerve is not in the coverage area of ​​the current target electrode. Therefore, after controlling the ablation module to provide the ablation signal to the target electrode, the output module is re-controlled to provide the electrical stimulation signal to the ablation electrode group and obtain the physiological parameters, and re-determine whether the stimulation area corresponding to the ablation electrode group is still the recommended ablation area, that is, whether the pulmonary artery sympathetic nerve still exists in the area covered by the action range of the multiple electrodes in the ablation electrode group. In the case of determining that the current stimulation area is still the recommended ablation area, it means that there is no pulmonary artery sympathetic nerve in the coverage area of ​​the previous target electrode, so the release of the ablation signal cannot ablate the pulmonary artery sympathetic nerve, so it is necessary to replace a retransmitting electrode that has not been provided with an ablation signal as a new target electrode, and re-release the ablation signal for ablation. Repeat the above steps until it is determined that the current stimulation area is not the recommended ablation area.

[0082] In this embodiment, after controlling one electrode in the ablation electrode group to release ablation energy, the stimulation area corresponding to the ablation electrode group is re-detected to see if it is the recommended ablation area, so as to determine whether the pulmonary artery sympathetic nerve has been successfully ablated. When it is determined that the current stimulation area is still the recommended ablation area, it means that there are no pulmonary artery sympathetic nerves in the coverage area of ​​the previously selected target electrode. Therefore, another retransmission electrode that has not been provided with an ablation signal is selected as the new target electrode, and ablation is performed again until the pulmonary artery sympathetic nerves are cleared, thereby ensuring the ablation effect.

[0083] In one embodiment, the physiological parameter includes a blood pressure value. The control module is used to determine that the stimulation area corresponding to the at least one electrode is a recommended ablation area when the blood pressure value meets a preset blood pressure condition.

[0084] Among them, the preset blood pressure conditions include: the blood pressure value shows a continuous upward trend, and the blood pressure values ​​within the set time are all greater than the first preset value, or the blood pressure value first shows a downward trend and then an upward trend, and the blood pressure values ​​within the set time are all greater than the first preset value.

[0085] Specifically, when the blood pressure value shows a continuous upward trend, and the blood pressure values ​​within a set time are all greater than the first preset value, the stimulation area corresponding to the current at least one electrode can be classified into the first category. When the blood pressure value first shows a downward trend and then an upward trend, and the blood pressure values ​​within a set time are all greater than the first preset value, the stimulation area corresponding to the current at least one electrode can be classified into the second category. Both the first category and the second category determine the stimulation area corresponding to the current at least one electrode as the recommended ablation area, that is, the stimulation area corresponding to the current at least one electrode needs to be ablated. This is because of the existence of sympathetic nerves. After receiving stimulation signals, the sympathetic nerves will cause a large change in the blood pressure value of the object. If there are no sympathetic nerves, such changes will not occur. The change trends of blood pressure values ​​other than the first category and the second category are classified into the third category. In the case of the third category, there is no need to ablate the stimulation area corresponding to the current at least one electrode.

[0086] For example, a table for classifying the change trend of blood pressure values ​​is shown in Table 1:

[0087] Table 1. Classification table of blood pressure value change trend

[0088]

[0089] The first preset value is the blood pressure value when no electrical stimulation signal is applied.

[0090] For example, the first category of the change trend graph of blood pressure values ​​is as follows: Figure 6 As shown, the second category of blood pressure value change trend diagram is as follows Figure 7 shown.

[0091] Specifically, when the physiological parameters include blood pressure values, such as Figure 8 As shown, the workflow of the ablation system of the present application includes:

[0092] Step S800, obtaining a first preset value.

[0093] Step S810: providing an electrical stimulation signal to the target electrode pair.

[0094] The initial target electrode pair is a randomly selected electrode pair.

[0095] The time for applying the electrical stimulation signal may be 0-180 seconds, preferably 60 seconds.

[0096] Step S820, obtaining a blood pressure value during the process of providing an electrical stimulation signal to the electrode pair.

[0097] Step S830, determining whether the blood pressure value satisfies the preset blood pressure condition. If the blood pressure value satisfies the preset blood pressure condition, step S840 is executed, otherwise, another electrode pair that has not been provided with an electrical stimulation signal is selected as the target electrode pair, and the process returns to step S810.

[0098] Step S840: providing an ablation signal to the target electrode.

[0099] The time for applying the ablation signal may be 0-180 seconds, preferably 60 seconds.

[0100] Step S850, determine whether all electrode pairs have been provided with electrical stimulation signals. If all electrode pairs have been provided with electrical stimulation signals, it is determined that the ablation is completed, otherwise another electrode pair that has not been provided with electrical stimulation signals is selected as the target electrode pair, and the process returns to step S810.

[0101] In this embodiment, whether the stimulation area corresponding to at least one electrode is the recommended ablation area is determined by the change trend of the blood pressure value, so that the recommended ablation area can be accurately located to achieve more precise ablation.

[0102] In one embodiment, the physiological parameter includes a heart rate value. The control module is used to determine that the stimulation area corresponding to the at least one electrode is a recommended ablation area when the heart rate value meets a preset heart rate condition.

[0103] The preset heart rate condition includes: the absolute value of the change rate of the heart rate value relative to the second preset value exceeds a set threshold.

[0104] Specifically, when the heart rate value shows a continuous upward trend, and the rate of change of the heart rate value relative to the second preset value exceeds the set threshold, the stimulation area corresponding to the current at least one electrode can be classified into the fourth category. When the heart rate value shows a continuous downward trend, and the rate of change of the heart rate value relative to the second preset value exceeds the set threshold, the stimulation area corresponding to the current at least one electrode can be classified into the fifth category. Both the fourth and fifth categories determine the stimulation area corresponding to the current at least one electrode as a recommended ablation area, that is, the stimulation area corresponding to the current at least one electrode needs to be ablated. This is because of the existence of sympathetic nerves. After receiving stimulation signals, the sympathetic nerves will cause a large change in the heart rate value of the object. If there are no sympathetic nerves, such changes will not occur. When the absolute value of the rate of change of the heart rate value relative to the second preset value does not exceed the set threshold, the stimulation area corresponding to the current at least one electrode can be classified into the sixth category. In the case of the sixth category, there is no need to ablate the stimulation area corresponding to the current at least one electrode.

[0105] For example, a table for classifying the change trend of the heart rate value is shown in Table 2:

[0106] Table 2. Classification table of heart rate value change trend

[0107]

[0108] Among them, the second preset value is the heart rate value when no electrical stimulation signal is applied.

[0109] For example, the change trend diagram of the fourth category of heart rate value is as follows: Fig. 9 As shown, the fifth category of heart rate value change trend diagram is as follows Fig.10 As shown, the sixth category of heart rate value change trend diagram is as follows Fig.11 shown.

[0110] Specifically, when the physiological parameters include heart rate values, such as Fig.12 As shown, the workflow of the ablation system of the present application includes:

[0111] Step S1200, obtaining a second preset value.

[0112] Step S1210, providing an electrical stimulation signal to the target electrode pair.

[0113] The initial target electrode pair is a randomly selected electrode pair.

[0114] The time for applying the electrical stimulation signal may be 0-180 seconds, preferably 60 seconds.

[0115] Step S1220, obtaining a heart rate value during the process of providing an electrical stimulation signal to the electrode pair.

[0116] Step S1230, determining whether the heart rate value satisfies the preset heart rate condition. If the heart rate value satisfies the preset heart rate condition, executing step S1240, otherwise, selecting another electrode pair that has not been provided with an electrical stimulation signal as the target electrode pair, and returning to executing step S1210.

[0117] Step S1240: providing an ablation signal to the target electrode.

[0118] The time for applying the ablation signal may be 0-180 seconds, preferably 60 seconds.

[0119] Step S1250, determine whether all electrode pairs have been provided with electrical stimulation signals. If all electrode pairs have been provided with electrical stimulation signals, it is determined that ablation is completed, otherwise another electrode pair that has not been provided with electrical stimulation signals is selected as the target electrode pair, and the process returns to step S1210.

[0120] In this embodiment, whether the stimulation area corresponding to at least one electrode is the recommended ablation area is determined by the change trend of the heart rate value, so that the recommended ablation area can be accurately located to achieve more precise ablation.

[0121] In one embodiment, Fig.13 , Fig.14 , Fig.15 As shown, the acquisition module further includes: a blood pressure acquisition unit 71 and / or a heart rate acquisition unit 72, wherein:

[0122] The blood pressure acquisition unit 71 is connected to the control module 40 and an external blood pressure sensor, and is used to obtain the blood pressure value measured by the blood pressure sensor.

[0123] Among them, the blood pressure sensor can measure the blood pressure value of the target object, and then transmit it to the blood pressure acquisition unit 71. The blood pressure acquisition unit 71 pre-processes the received blood pressure value (such as filtering, analog-to-digital conversion, etc.), converts it into an electrical signal and transmits it to the control module 40.

[0124] The heart rate acquisition unit 72 is connected to the control module 40 and an external heart rate measurement device, and is used to obtain the heart rate value measured by the heart rate measurement device.

[0125] The heart rate acquisition unit 72 may be a communication module, and the heart rate measurement device may measure the heart rate value of the target object and then transmit the value to the heart rate acquisition unit 72 through communication.

[0126] The control module 40 is used to determine that the stimulation area corresponding to the at least one electrode 20 is a recommended ablation area when the heart rate value meets the preset heart rate condition or the blood pressure value meets the preset blood pressure condition.

[0127] Specifically, when one of the two conditions, that is, the heart rate value satisfies the preset heart rate condition and the blood pressure value satisfies the preset blood pressure condition, the stimulation area corresponding to the at least one electrode 20 is determined to be the recommended ablation area.

[0128] In this embodiment, the control module 40 determines whether the stimulation area corresponding to at least one electrode 20 is a recommended ablation area based on the blood pressure value and the heart rate value, thereby improving the accuracy of the determination of the recommended ablation area.

[0129] In one embodiment, Fig.16 As shown, a control method of an ablation system is provided, which is applied to the aforementioned ablation system, and the method comprises:

[0130] Step S1600, providing an electrical stimulation signal to at least one electrode in sequence.

[0131] Step S1610, in the process of providing an electrical stimulation signal to at least one electrode, obtaining a physiological parameter of an object acted upon by at least one electrode.

[0132] The physiological parameter may be blood pressure and / or heart rate.

[0133] Step S1620, determining whether the stimulation area corresponding to the current electrode is a recommended ablation area according to the physiological parameters.

[0134] Among them, according to one of the blood pressure and the heart rate, it can be determined whether the stimulation area corresponding to the current electrode is the recommended ablation area.

[0135] In this embodiment, by sequentially providing an electrical stimulation signal to at least one electrode, each electrode can sequentially release an electrical stimulation signal, and sequentially apply the electrical stimulation signal to different positions in the pulmonary artery of the target object. Then, based on the physiological parameters under the action of the electrical stimulation signal, it is determined whether the stimulation area corresponding to the current electrode is the recommended ablation area, so that the position of the sympathetic nerves of the pulmonary artery, that is, the position of the recommended ablation area, can be accurately found. Since the ablation energy is more harmful to the target object, the system of the present application is used to improve the accuracy of locating the recommended ablation area, which can improve the accuracy of applying the ablation energy, and while ensuring the ablation effect, avoid the wrong position of applying the ablation energy and cause unnecessary damage to the target object.

[0136] In one embodiment, the physiological parameter includes a blood pressure value, and step S1620 determines whether the stimulation area corresponding to the current electrode is a recommended ablation area according to the physiological parameter. Specifically, it includes: when the blood pressure value meets the preset blood pressure condition, determining that the stimulation area corresponding to at least one electrode is a recommended ablation area.

[0137] Among them, the preset blood pressure conditions include: the blood pressure value shows a continuous upward trend, and the blood pressure values ​​within the set time are all greater than the first preset value; or, the blood pressure value first shows a downward trend and then an upward trend, and the blood pressure values ​​within the set time are all greater than the first preset value; among them, the first preset value is the blood pressure value when no electrical stimulation signal is applied.

[0138] In this embodiment, whether the stimulation area corresponding to at least one electrode is the recommended ablation area is determined by the change trend of the blood pressure value, so that the recommended ablation area can be accurately located to achieve more precise ablation.

[0139] In one embodiment, the physiological parameter includes a heart rate value, and step S1620 determines whether the stimulation area corresponding to the current electrode is a recommended ablation area according to the physiological parameter, specifically including: when the heart rate value meets the preset heart rate condition, determining that the stimulation area corresponding to at least one electrode is a recommended ablation area.

[0140] Among them, the preset heart rate condition includes: the absolute value of the change rate of the heart rate value relative to the second preset value exceeds the set threshold, wherein the second preset value is the heart rate value when no electrical stimulation signal is applied.

[0141] The threshold value may be set to 15%. The second preset value may be an average value of the heart rate values ​​5-10 seconds before the electrical stimulation signal is applied.

[0142] In this embodiment, whether the stimulation area corresponding to at least one electrode is the recommended ablation area is determined by the change trend of the heart rate value, so that the recommended ablation area can be accurately located to achieve more precise ablation.

[0143] It should be understood that although Figure 8 , 12 The steps in the flowchart of 16 are shown in sequence according to the arrows, but these steps are not necessarily executed in the order indicated by the arrows. Unless otherwise specified in this document, there is no strict order restriction for the execution of these steps, and these steps can be executed in other orders. Moreover, Figure 8 , 12 At least part of the steps in 16 may include multiple steps or multiple stages. These steps or stages are not necessarily performed at the same time, but can be performed at different times. The execution order of these steps or stages is not necessarily sequential, but can be performed in turn or alternately with other steps or at least part of the steps or stages in other steps.

[0144] Those of ordinary skill in the art can understand that all or part of the processes in the above-mentioned embodiment methods can be completed by instructing the relevant hardware through a computer program, and the computer program can be stored in a non-volatile computer-readable storage medium. When the computer program is executed, it can include the processes of the embodiments of the above-mentioned methods. Among them, any reference to memory, storage, database or other media used in the embodiments provided in this application can include at least one of non-volatile and volatile memory. Non-volatile memory can include read-only memory (ROM), magnetic tape, floppy disk, flash memory or optical memory, etc. Volatile memory can include random access memory (RAM) or external cache memory. As an illustration and not limitation, RAM can be in various forms, such as static random access memory (SRAM) or dynamic random access memory (DRAM).

[0145] In the description of this specification, the description with reference to the terms "some embodiments", "other embodiments", "ideal embodiments", etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic descriptions of the above terms do not necessarily refer to the same embodiment or example.

[0146] The technical features of the above embodiments may be combined arbitrarily. To make the description concise, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0147] The above-mentioned embodiments only express several implementation methods of the present application, and the descriptions thereof are relatively specific and detailed, but they cannot be understood as limiting the scope of the invention patent. It should be pointed out that, for a person of ordinary skill in the art, several variations and improvements can be made without departing from the concept of the present application, and these all belong to the protection scope of the present application. Therefore, the protection scope of the patent of the present application shall be subject to the attached claims.

Claims

1. An ablation system, characterized in that: include: catheter; A plurality of electrodes, each of which is arranged on the catheter at intervals; an output module, connected to the plurality of electrodes respectively, for providing an electrical stimulation signal to each of the electrodes, wherein the electrical stimulation signal is used to activate the pulmonary artery sympathetic nerve; A collection module, used for collecting physiological parameters of the subject of the plurality of electrodes; The control module is connected to the output module and the acquisition module respectively, and is used to control the output module to provide the electrical stimulation signal to at least one of the electrodes in sequence, and to obtain the physiological parameters through the acquisition module, and to determine whether the stimulation area corresponding to the current electrode is the recommended ablation area based on the physiological parameters under the action of the electrical stimulation signal.

2. The ablation system according to claim 1, characterized in that: The catheter comprises a support portion and an electrode portion, wherein the electrode portion is a flexible hose; The plurality of electrodes are arranged at intervals on the electrode portion.

3. The ablation system according to claim 1, characterized in that: The control module is used to control the output module to provide the electrical stimulation signal to at least one of the electrodes in sequence according to a preset order.

4. The ablation system according to claim 2, characterized in that: The preset order is from the electrode farthest from the support portion to the electrode closest to the support portion, or the preset order is from the electrode closest to the support portion to the electrode farthest from the support portion.

5. The ablation system according to claim 3, characterized in that: The control module is used to control the output module to provide electrical stimulation signals to the electrode pair in sequence according to the preset order; wherein the electrode pair includes two electrodes arranged adjacent to each other.

6. The ablation system according to any one of claims 1 to 5, characterized in that: The ablation system also includes an ablation module respectively connected to the multiple electrodes, wherein the control module is also used to determine the ablation electrode group when it is determined that the stimulation area is the recommended ablation area, and control the ablation module to provide an ablation signal to the target electrode, wherein the effective range of each electrode included in the ablation electrode group at least covers the recommended ablation area, and the target electrode is one of the ablation electrode groups.

7. The ablation system according to claim 6, characterized in that: The ablation system further comprises: Neutral electrodes, connected to the output module and the ablation module respectively; The control module is used to control the output module to conduct the path between at least one of the electrodes and the neutral electrode to establish a stimulation circuit, wherein the output module provides an electrical stimulation signal to at least one of the electrodes through the stimulation circuit.

8. The ablation system according to claim 7, characterized in that: The control module is further configured to, after determining the recommended ablation area, open a path between the target electrode and the neutral electrode to establish an ablation circuit, wherein the ablation module provides an ablation signal to the target electrode through the ablation circuit.

9. The ablation system according to claim 6, characterized in that: When there are multiple electrodes included in the ablation electrode group, the control module is also used to re-control the output module to provide electrical stimulation signals to the ablation electrode group and obtain the physiological parameters after controlling the ablation module to provide ablation signals to the target electrode, and when it is determined according to the physiological parameters that the current stimulation area is still the recommended ablation area, control the ablation module to provide ablation signals to the retransmission electrode, wherein the retransmission electrode is the electrode in the ablation electrode group that has not been provided with the ablation signal.

10. The ablation system according to any one of claims 1 to 5, characterized in that: The physiological parameters include blood pressure values; The control module is used to determine that the stimulation area corresponding to at least one of the electrodes is a recommended ablation area when the blood pressure value meets the preset blood pressure condition; wherein the preset blood pressure condition includes: The blood pressure value shows a continuous upward trend, and the blood pressure values ​​within the set time period are all greater than the first preset value; or, The blood pressure value first shows a downward trend and then an upward trend, and the blood pressure values ​​within a set time period are all greater than a first preset value; wherein the first preset value is the blood pressure value when the electrical stimulation signal is not applied.

11. The ablation system according to any one of claims 1 to 5, characterized in that: The physiological parameters include heart rate value; The control module is used to determine that the stimulation area corresponding to at least one of the electrodes is a recommended ablation area when the heart rate value meets the preset heart rate condition; wherein the preset heart rate condition includes: An absolute value of the rate of change of the heart rate value relative to a second preset value exceeds a set threshold, wherein the second preset value is a heart rate value when the electrical stimulation signal is not applied.

12. The ablation system according to any one of claims 1 to 5, characterized in that: The acquisition module comprises: a blood pressure acquisition unit connected to the control module and an external blood pressure sensor, for acquiring the blood pressure value measured by the blood pressure sensor; and / or, A heart rate acquisition unit, connected to the control module and an external heart rate measurement device, for acquiring the heart rate value measured by the heart rate measurement device; The control module is used to determine that the stimulation area corresponding to at least one of the electrodes is a recommended ablation area when the heart rate value meets a preset heart rate condition or when the blood pressure value meets a preset blood pressure condition.

13. A control method for an ablation system, characterized in that: Applied to the ablation system according to any one of claims 1 to 12, the method comprising: sequentially providing an electrical stimulation signal to at least one of the electrodes; In the process of providing the electrical stimulation signal to at least one of the electrodes, obtaining physiological parameters of the subject acted upon by at least one of the electrodes; Determine whether the stimulation area currently corresponding to the electrode is a recommended ablation area according to the physiological parameters.

14. The control method of the ablation system according to claim 13, characterized in that: The physiological parameter includes a blood pressure value; and determining whether the stimulation area corresponding to the current electrode is a recommended ablation area according to the physiological parameter includes: In the case where the blood pressure value meets the preset blood pressure condition, determining that the stimulation area corresponding to the at least one electrode is currently a recommended ablation area; wherein the preset blood pressure condition includes: The blood pressure value shows a continuous upward trend, and the blood pressure values ​​within the set time period are all greater than the first preset value; or, The blood pressure value first shows a downward trend and then an upward trend, and the blood pressure values ​​within a set time period are all greater than a first preset value; wherein the first preset value is the blood pressure value when the electrical stimulation signal is not applied.

15. The control method of the ablation system according to claim 13, characterized in that: The physiological parameter includes a heart rate value; and determining whether the stimulation area corresponding to the current electrode is a recommended ablation area according to the physiological parameter includes: In the case where the heart rate value meets the preset heart rate condition, determining that the stimulation area corresponding to the at least one electrode is currently the recommended ablation area; wherein the preset heart rate condition includes: An absolute value of the rate of change of the heart rate value relative to a second preset value exceeds a set threshold, wherein the second preset value is a heart rate value when the electrical stimulation signal is not applied.

16. The control method of the ablation system according to claim 15, characterized in that: The set threshold is 15%.

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