Subcutaneous pump based on signal remote transmission
By embedding the monitor in the subcutaneous pump to monitor the subcutaneous temperature and tissue pressure in real time, the problem that the existing subcutaneous pump cannot be monitored in real time, and improved the accuracy of the experimental data and the comfort of the animal.
Patent Information
- Application Number
- CN202411745958.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-02
- Publication Date
- 2025-01-28
AI Technical Summary
The existing subcutaneous pumps cannot monitor the subcutaneous tissue pressure of experimental animals in real time during the administration to animals, resulting in incomplete experimental data and frightened animals during the detection process, causing errors.
A subcutaneous pump based on signal -based remote transmission is designed, using a semi -diaphragm housing and a drug storage capsule structure, and embedding a monitor in the semi -transparent membrane shell. It is connected to the remote terminal signal through the Internet of Things to monitor the subcutaneous of the animal in real time in real time. Temperature and tissue pressure.
Real -time monitoring of the subcutaneous temperature and tissue pressure of animals, improved the accuracy of experimental data, reduced the working time of the experimental personnel, and reduced the frightening and stress response of animals.
Smart Images
Figure CN119367096A_ABST
Abstract
Description
Technical Field
[0001] The invention relates to the technical field of subcutaneous pumps, in particular to a subcutaneous pump based on remote signal transmission. Background Art
[0002] Subcutaneous pump, also known as osmotic pump, is a controlled-release drug delivery structure designed based on the osmotic principle. It can release drugs at a constant rate within a predetermined time. Due to its sustained release characteristics, in drug delivery studies in animal models, subcutaneous pumps can reduce the number of medications and improve medication compliance.
[0003] Although the existing subcutaneous pumps can select different models to set the drug administration speed, during the drug administration process, the experimenters are required to regularly check the vital signs of the experimental animals. Due to problems such as working hours and working hours, it is easy for the experimenters to cause discontinuity in the measured values and lead to incomplete experimental data. The existing osmotic pumps cannot monitor the subcutaneous tissue pressure of the experimental animals in real time during the drug administration process, and the animals are tested multiple times, which not only consumes the experimenters' time, but also the animals will be frightened and produce physiological stress responses during the test, resulting in errors in the experimental data. Summary of the invention
[0004] In order to overcome the shortcomings of the existing subcutaneous pumps, the present invention provides a subcutaneous pump based on remote signal transmission.
[0005] Technical solution: A subcutaneous pump based on remote signal transmission, comprising a semipermeable membrane shell, a drug storage bag is arranged inside the semipermeable membrane shell, the drug storage bag is provided with a drug injection port, the side of the drug storage bag close to the drug injection port is fixedly connected to the semipermeable membrane shell, the semipermeable membrane shell is provided with a sealing port connected to the drug storage bag, an annular cavity is formed between the drug storage bag and the semipermeable membrane shell, the annular cavity between the drug storage bag and the semipermeable membrane shell is filled with a hypertonic salt interlayer, the hypertonic salt interlayer is fitted with the drug storage bag and the semipermeable membrane shell, a cap is arranged at the sealing port of the semipermeable membrane shell, the cap is embedded with a guide tube, the guide tube is inserted into the sealing port of the semipermeable membrane shell, the guide tube is sealed with the semipermeable membrane shell and the drug storage bag, the semipermeable membrane shell is embedded with a monitor, the monitor is connected to a remote terminal signal through the Internet of Things, and the monitor is used to monitor the subcutaneous temperature and tissue pressure of the animal.
[0006] Furthermore, the medicine storage bag is made of elastic material and will shrink toward the middle after being squeezed, so as to discharge the medicine liquid inside the medicine storage bag.
[0007] Furthermore, the outer side surface of the monitor is flush with the outer surface of the semipermeable membrane housing, and the monitor is provided with an internal power supply to ensure that the monitor can work for a long time.
[0008] Furthermore, the cross section of the semipermeable membrane shell is set to be an ellipse, which facilitates the contact between the semipermeable membrane shell and the monitor and the subcutaneous tissue.
[0009] Furthermore, it also includes a limiting ring, which is fixed to the side of the semipermeable membrane shell close to the cap, and the side of the cap close to the limiting ring is provided with an annular limiting groove, and the limiting ring is limitedly matched with the annular limiting groove of the cap to improve the connection strength between the semipermeable membrane shell and the cap.
[0010] Furthermore, it also includes an extrusion ring, the inner wall of the semipermeable membrane shell is provided with an annular groove, the extrusion ring is arranged in the annular groove of the semipermeable membrane shell, the extrusion ring is located between the semipermeable membrane shell and the medicine storage bag, the extrusion ring is in contact with the medicine storage bag, the semipermeable membrane shell is slidably connected with symmetrical sliding rods, the sliding rods are fixedly connected to the extrusion ring, the symmetrical sliding rods are jointly fixed with a connecting ring, the connecting ring is located between the cap and the semipermeable membrane shell, the cap is provided with an annular groove on one side close to the semipermeable membrane shell, the depth of the annular groove of the semipermeable membrane shell is the same as the thickness of the connecting ring, and the annular groove of the cap is extruded and matched with the connecting ring.
[0011] Furthermore, the injection port of the medicine storage bag protrudes upward and is pressed together with the connecting ring to actively squeeze the medicine liquid in the medicine storage bag outward.
[0012] Furthermore, it also includes an elastic column, which is fixedly connected to one end of the guide tube away from the cap, the guide tube is provided with through holes with circumferentially equal spacing, the through holes of the guide tube are used to guide the medicine liquid, and the end of the elastic column away from the guide tube is fixedly connected to a stirring ball, and the stirring ball is used to stir the medicine liquid in the medicine storage bag.
[0013] Furthermore, the elastic force of the elastic column is greater than the gravity of the stirring ball, and the elastic column maintains an upright state.
[0014] Furthermore, the diameter of the stirring ball is smaller than that of the flow guide tube, so that the stirring ball can pass through the sealing opening of the semipermeable membrane shell and the drug injection port in the drug storage bag.
[0015] Compared with the prior art, the present invention has the following advantages: 1. The present invention utilizes a monitor to perform real-time detection of the subcutaneous temperature and tissue pressure of an animal, and sends the detection results in the form of a signal to a remote control terminal, thereby realizing real-time detection of the animal's physical condition, improving the accuracy of experimental data, and saving the working time of experimenters.
[0016] 2. The present invention utilizes the limiting ring and the cap to be in limiting cooperation, thereby improving the connection strength between the cap and the semipermeable membrane housing.
[0017] 3. The present invention presses down the cap so that the extrusion ring presses the protrusion of the medicine storage bag downward, thereby exhausting the residual air in the guide tube and reducing the influence of the residual air on the experimental data.
[0018] 4. The present invention utilizes the activities of animals to make the stirring ball stir the medicine liquid in the medicine storage capsule, thereby reducing the precipitation of the medicine liquid in the medicine storage capsule, improving the stability of the medicine liquid release rate, and improving the accuracy of the experimental results. BRIEF DESCRIPTION OF THE DRAWINGS
[0019] Figure 1 It is a schematic diagram of the three-dimensional structure of the present invention; Figure 2 It is a cross-sectional view of the semipermeable membrane shell and the drug storage capsule of the present invention; Figure 3 It is a three-dimensional structure explosion diagram of the cap, the limiting ring and other parts of the present invention; Figure 4 It is a schematic diagram of the three-dimensional structure of the elastic column, stirring ball and other parts of the present invention.
[0020] Markings in the accompanying drawings: 1: semipermeable membrane shell, 2: drug storage bag, 3: hypertonic salt interlayer, 4: cap, 5: flow guide tube, 6: monitor, 7: limit ring, 8: squeeze ring, 9: sliding rod, 10: connecting ring, 11: elastic column, 12: stirring ball. DETAILED DESCRIPTION
[0021] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.
[0022] Embodiment 1: It has been found that the existing subcutaneous pump cannot detect the body temperature and tissue pressure of animals in real time, which leads to missed detection and misdetection during the experiment, resulting in errors in the experimental data. In addition, multiple detections of animals not only waste the time of the experimenters, but also scare the animals during the detection process and produce physiological stress reactions, resulting in errors in the experimental data. To solve the above problems, the following implementation method is adopted.
[0023] A subcutaneous pump based on remote signal transmission, such as Figure 1 and Figure 2As shown, it includes a semipermeable membrane shell 1, a drug storage bag 2 is arranged inside the semipermeable membrane shell 1, the drug storage bag 2 is provided with a drug injection port, the upper side of the drug storage bag 2 is fixedly connected to the semipermeable membrane shell 1, the semipermeable membrane shell 1 is provided with a sealing port connected to the drug storage bag 2, the central axis of the sealing port of the semipermeable membrane shell 1 coincides with the central axis of the drug injection port of the drug storage bag 2, an annular cavity is formed between the drug storage bag 2 and the semipermeable membrane shell 1, and the space between the drug storage bag 2 and the semipermeable membrane shell 1 is 400 mm. The annular cavity is filled with a hypertonic salt interlayer 3, which absorbs the body fluid of the subcutaneous tissue and expands. The hypertonic salt interlayer 3 is fitted with the drug storage bag 2 and the semipermeable membrane shell 1. A cap 4 is provided at the sealing opening of the semipermeable membrane shell 1. The cap 4 is embedded with a guide tube 5. The guide tube 5 is used to discharge the drug solution of the drug storage bag 2. The guide tube 5 is inserted into the sealing opening of the semipermeable membrane shell 1. The guide tube 5 is sealed with the semipermeable membrane shell 1 and the drug storage bag 2 to prevent the drug from leaking. The liquid overflows from between the semipermeable membrane shell 1 and the guide tube 5, resulting in unstable drug administration efficiency. The semipermeable membrane shell 1 is embedded with a monitor 6, which is connected to the remote terminal signal through the Internet of Things. The monitor 6 is used to monitor the temperature and tissue pressure under the skin of the animal, reduce the number of animal inspections, save the time of the experimenter, and reduce the fright of the animal. The drug storage bag 2 is made of elastic material and will shrink toward the middle after being squeezed, which is used to discharge the drug liquid inside the drug storage bag 2. The drug storage bag 2 cannot be reset after being squeezed, and the drug storage bag 2 can only be used once. The outer side surface of the monitor 6 is flush with the outer surface of the semipermeable membrane shell 1, which is convenient for inserting the subcutaneous pump into the subcutaneous tissue of the animal, and the monitor 6 is provided with an internal power supply to ensure that the monitor 6 works for a long time. The cross-section of the semipermeable membrane shell 1 is set to an ellipse, which is convenient for the semipermeable membrane shell 1 and the monitor 6 to contact with the subcutaneous tissue and reduce the support height between the animal's skin and tissue.
[0024] When using the subcutaneous pump, the experimenter injects the drug solution into the drug storage bag 2 with a syringe, and then inserts the guide tube 5 into the sealing port of the semipermeable membrane shell 1 and the drug injection port of the drug storage bag 2 until the cap 4 contacts the upper side of the semipermeable membrane shell 1. The experimenter inserts the subcutaneous pump into the subcutaneous tissue of the animal and sutures the animal's wound. Since the hypertonic salt interlayer 3 belongs to a hypertonic environment, the hypertonic salt interlayer 3 absorbs the body fluid outside the semipermeable membrane shell 1, and the body fluid flows into the hypertonic salt interlayer 3 through the semipermeable membrane shell 1. The salt-infiltrated interlayer 3 expands and squeezes the outside of the drug storage bag 2, and the drug storage bag 2 contracts inward, squeezing the drug solution inside it, so that the drug solution flows into the animal body along the guide tube 5, and the experimenter starts the monitor 6 through the remote control terminal. The monitor 6 detects the subcutaneous temperature and tissue pressure of the animal in real time, and sends the detection result to the remote control terminal in the form of a signal, thereby realizing real-time detection of the animal's physical condition, improving the accuracy of the experimental data, and saving the working time of the experimenter.
[0025] Embodiment 2: Based on embodiment 1, Figure 3 As shown, it also includes a limiting ring 7, which is fixedly connected to the upper side of the semipermeable membrane shell 1. The lower side of the cap 4 is provided with an annular limiting groove. The limiting ring 7 cooperates with the annular limiting groove of the cap 4 to improve the connection strength between the semipermeable membrane shell 1 and the cap 4, and ensures that the cap 4 is always in a fit with the semipermeable membrane shell 1.
[0026] like Figure 3 As shown, it also includes a squeezing ring 8, the inner wall of the semipermeable membrane shell 1 is provided with an annular groove, the squeezing ring 8 is arranged in the annular groove of the semipermeable membrane shell 1, the squeezing ring 8 is located between the semipermeable membrane shell 1 and the drug storage bag 2, the squeezing ring 8 is in contact with the drug storage bag 2, the squeezing ring 8 is used to squeeze the drug storage bag 2 downward, so that the drug storage bag 2 discharges part of the liquid medicine, reduces the air content in the guide tube 5, and improves the accuracy of the experimental value, the semipermeable membrane shell 1 is slidably connected to two symmetrical sliding rods 9, the sliding rods 9 are fixedly connected to the squeezing ring 8, the two sliding rods 9 are commonly fixedly connected to a connecting ring 10, and the connecting ring 10 It is elliptical in shape, and the connecting ring 10 is located between the cap 4 and the semipermeable membrane shell 1. An annular groove is arranged on the lower side of the cap 4. The depth of the annular groove of the semipermeable membrane shell 1 is the same as the thickness of the connecting ring 10, so as to ensure that the upper side of the semipermeable membrane shell 1 can fit with the cap 4. The annular groove of the cap 4 is squeezed and matched with the connecting ring 10. The injection port of the medicine storage bag 2 protrudes upward and is squeezed and matched with the connecting ring 10, so as to actively squeeze the medicine liquid in the medicine storage bag 2 outward. When the cap 4 squeezes the connecting ring 10 downward, the squeezing ring 8 squeezes the protrusion of the medicine storage bag 2 to discharge the liquid under the drive of the two sliding rods 9.
[0027] Before using the subcutaneous pump, a syringe is required to inject liquid medicine into the drug storage bag 2. After the injection is completed, the experimenter inserts the guide tube 5 into the sealing port of the semipermeable membrane shell 1 and the injection port of the drug storage bag 2 (with Figure 1 perspective), the semipermeable membrane shell 1 seals the guide tube 5, and when the cap 4 and the guide tube 5 move, the annular limit groove of the cap 4 contacts the limit ring 7, and then is pressed down with force, the limit ring 7 is deformed and enters the annular limit groove of the cap 4, and then the limit ring 7 is reset to its initial state. At this time, the limit ring 7 and the cap 4 are in a limit fit, thereby improving the connection strength between the cap 4 and the semipermeable membrane shell 1.
[0028] In the process of pressing down the cap 4, the connecting ring 10 is also located in the annular groove of the cap 4. When the cap 4 moves downward, the cap 4 squeezes the connecting ring 10 downward, and the connecting ring 10 drives the squeezing ring 8 to move downward synchronously through the two sliding rods 9. The squeezing ring 8 squeezes the protrusion of the medicine storage bag 2 downward, and the medicine storage bag 2 is deformed. The medicine liquid in the medicine storage bag 2 is discharged upward along the guide tube 5, thereby discharging the residual air in the guide tube 5, reducing the influence of the residual air on the experimental data, and the excess medicine liquid flows out from the upper end of the guide tube 5. The experimenter cleans up the overflowed medicine liquid in time, and then repeats the above operation to place the subcutaneous pump in the subcutaneous tissue of the animal.
[0029] Embodiment 3: Based on embodiment 2, Figure 2 and Figure 4 As shown, it also includes an elastic column 11, which is fixedly connected to the lower end of the guide tube 5. The guide tube 5 is provided with through holes with circumferential equal spacing. The through holes of the guide tube 5 are used to guide the medicine liquid. The medicine liquid flows into the interior of the guide tube 5 through the through holes and flows upward, and the medicine liquid flows out from the upper end. A stirring ball 12 is fixedly connected to the lower end of the elastic column 11. The stirring ball 12 is used to stir the medicine liquid in the medicine storage bag 2. During the animal's activities, the stirring ball 12 shakes under the action of inertia and stirs the medicine liquid in the medicine storage bag 2 to reduce the precipitation of the medicine liquid. The elastic force of the elastic column 11 is greater than the gravity of the stirring ball 12. The elastic column 11 remains upright and will not affect the normal contraction of the medicine storage bag 2 due to the deflection of the stirring ball 12. The diameter of the stirring ball 12 is smaller than the guide tube 5, which is convenient for the stirring ball 12 to pass through the sealing port of the semipermeable membrane shell 1 and the injection port in the medicine storage bag 2, thereby improving the practicality of the subcutaneous pump.
[0030] After the medicine storage bag 2 is filled with liquid medicine, the guide tube 5 is inserted into the semipermeable membrane shell 1 and the medicine storage bag 2, and the stirring ball 12 and the elastic column 11 pass through the sealing port of the semipermeable membrane shell 1 and the injection port of the medicine storage bag 2 in turn until the guide tube 5 stops moving. After the subcutaneous pump is inserted into the subcutaneous tissue of the animal, when the animal resumes normal activities, during the animal's activities or eating, the animal's body shakes, thereby driving the subcutaneous pump to move synchronously, and then the stirring ball 12 at this time shakes in the medicine storage bag 2 under the action of inertia, and when the animal stops moving, the stirring ball 12 is reset under the elastic force of the elastic column 11, and the stirring ball 12 is used to stir the liquid medicine in the medicine storage bag 2, thereby reducing the precipitation of the liquid medicine in the medicine storage bag 2, improving the stability of the liquid medicine release rate, and improving the accuracy of the experimental results.
[0031] Finally, it should be noted that the above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art can still modify the technical solutions described in the aforementioned embodiments or replace some of the technical features therein by equivalents. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.
Claims
1. A subcutaneous pump based on remote signal transmission, characterized by: The invention comprises a semipermeable membrane shell (1), wherein a drug storage bag (2) is arranged inside the semipermeable membrane shell (1), wherein the drug storage bag (2) is provided with a drug injection port, wherein a side of the drug storage bag (2) close to the drug injection port is fixedly connected to the semipermeable membrane shell (1), wherein the semipermeable membrane shell (1) is provided with a sealing port communicating with the drug storage bag (2), wherein an annular cavity is formed between the drug storage bag (2) and the semipermeable membrane shell (1), wherein a hypertonic salt interlayer (3) is filled in the annular cavity between the drug storage bag (2) and the semipermeable membrane shell (1), wherein the hypertonic salt interlayer (3) is connected to the semipermeable membrane shell (1) and the drug storage bag (2) is connected to the semipermeable membrane shell (1). The medicine storage bag (2) and the semipermeable membrane shell (1) are both fitted together; a cap (4) is provided at the sealing opening of the semipermeable membrane shell (1); a flow guide tube (5) is embedded in the cap (4); the flow guide tube (5) is inserted into the sealing opening of the semipermeable membrane shell (1); the flow guide tube (5) is sealed with the semipermeable membrane shell (1) and the medicine storage bag (2); a monitor (6) is embedded in the semipermeable membrane shell (1); the monitor (6) is connected to a remote terminal signal via an Internet of Things; the monitor (6) is used to monitor the subcutaneous temperature and tissue pressure of an animal.
2. A subcutaneous pump based on remote signal transmission according to claim 1, characterized in that: The medicine storage bag (2) is made of an elastic material and will shrink towards the middle when squeezed, so as to discharge the medicine liquid inside the medicine storage bag (2).
3. A subcutaneous pump based on remote signal transmission according to claim 2, characterized in that: The outer side surface of the monitor (6) is flush with the outer surface of the semipermeable membrane housing (1), and the monitor (6) is provided with an internal power supply to ensure that the monitor (6) can work for a long time.
4. A subcutaneous pump based on remote signal transmission according to claim 3, characterized in that: The cross section of the semipermeable membrane housing (1) is arranged to be an ellipse, so as to facilitate contact between the semipermeable membrane housing (1) and the monitor (6) and the subcutaneous tissue.
5. A subcutaneous pump based on remote signal transmission according to claim 4, characterized in that: The device further comprises a limiting ring (7), wherein the limiting ring (7) is fixedly connected to a side of the semipermeable membrane housing (1) close to the cap (4), and an annular limiting groove is provided on a side of the cap (4) close to the limiting ring (7). The limiting ring (7) and the annular limiting groove of the cap (4) are limitedly matched to each other, so as to improve the connection strength between the semipermeable membrane housing (1) and the cap (4).
6. A subcutaneous pump based on remote signal transmission according to claim 5, characterized in that: Also includes The semipermeable membrane housing (1) has an inner wall provided with an annular groove, the extrusion ring (8) is arranged in the annular groove of the semipermeable membrane housing (1), the extrusion ring (8) is located between the semipermeable membrane housing (1) and the medicine storage bag (2), the extrusion ring (8) is in contact with the medicine storage bag (2), the semipermeable membrane housing (1) is slidably connected with symmetrical sliding rods (9), the sliding rods (9) are fixedly connected to the extrusion ring (8), the symmetrical sliding rods (9) are jointly fixedly connected with a connecting ring (10), the connecting ring (10) is located between the cap (4) and the semipermeable membrane housing (1), the cap (4) is provided with an annular groove on one side close to the semipermeable membrane housing (1), the depth of the annular groove of the semipermeable membrane housing (1) is the same as the thickness of the connecting ring (10), and the annular groove of the cap (4) is in an extrusion fit with the connecting ring (10).
7. A subcutaneous pump based on remote signal transmission according to claim 6, characterized in that: The drug injection port of the drug storage bag (2) protrudes upwards and is pressed together with the connecting ring (10) to actively squeeze the drug liquid in the drug storage bag (2) outwards.
8. A subcutaneous pump based on remote signal transmission according to claim 7, characterized in that: The invention also comprises an elastic column (11), wherein the elastic column (11) is fixedly connected to one end of the guide tube (5) away from the cap (4), the guide tube (5) is provided with through holes at equal intervals in the circumferential direction, the through holes of the guide tube (5) are used to guide the medicine liquid, and the end of the elastic column (11) away from the guide tube (5) is fixedly connected to a stirring ball (12), and the stirring ball (12) is used to stir the medicine liquid in the medicine storage bag (2).
9. A subcutaneous pump based on remote signal transmission according to claim 8, characterized in that: The elastic force of the elastic column (11) is greater than the gravity of the stirring ball (12), and the elastic column (11) remains in an upright state.
10. A subcutaneous pump based on remote signal transmission according to claim 9, characterized in that: The diameter of the stirring ball (12) is smaller than that of the flow guide tube (5), so that the stirring ball (12) can pass through the sealing opening of the semipermeable membrane shell (1) and the injection opening in the medicine storage bag (2) easily.