Composition with immediate red fading and relieving effects as well as preparation method and application of composition

Abstract

The invention belongs to the technical field of cosmetics, and particularly relates to a composition with immediate red fading and relieving effects as well as a preparation method and application thereof. The composition comprises the following components in parts by weight: 5-15 parts of a scutellaria baicalensis root extract, 6-18 parts of a grapefruit extract, 5-15 parts of rhamnose and 85-105 parts of a cyclodextrin derivative. The four components are scientifically compounded to prepare the composition with the instant red fading and relieving effects, the four components are mutually matched and influenced, the heme EI value of the skin of a subject can be effectively reduced, the rapid red fading and relieving effects are achieved, the four components have an obvious synergistic interaction effect, and the composition has good stability and is suitable for being used in the field of skin care. And the compound has stable and lasting activity, and can be widely applied to the fields of cosmetics and biological medicines.

Description

Technical Field

[0001] The present invention belongs to the technical field of cosmetics, and in particular relates to a composition with instant redness-removing and soothing effects, and a preparation method and application thereof. Background Art

[0002] With the change of people's skin care habits and lifestyles, coupled with environmental changes such as air pollution, mental stress and other factors, the number of people with sensitive skin in China has increased year by year in recent years. They show symptoms of varying degrees, such as skin burning, itching, tightness, pain, redness and swelling. These skin discomfort symptoms are generally induced by endogenous or exogenous factors, and the redness and burning symptoms they bring are the most prominent. The mechanism behind them is closely related to increased vascular reactivity. For example, wind, sun, high temperature, low temperature and other stimuli make the tolerance of blood vessels exceed the normal range, thereby causing the expansion and rupture of capillaries. Incorrect skin care methods such as facial skin contact with some irritating chemicals or excessive cleaning may cause local inflammation, increase vasoactive substances, and easy expansion or regeneration of capillaries, which ultimately lead to skin sensitivity, red blood streaks and other symptoms of damaged barriers.

[0003] There are many cosmetics with soothing and repairing effects on the market: Chinese herbal extracts (Centella asiatica extract, Calendula officinalis extract, Hamamelis virginiana extract), ceramide, trehalose, dipotassium glycyrrhizinate, etc. These ingredients have been recognized by many consumers for their soothing and repairing effects, but it often takes a long time for the products to penetrate into the skin to achieve therapeutic effects, resulting in unsatisfactory absorption effects. Patients suffer from burning and itching, so it is particularly urgent to develop a product that can quickly fade redness and soothe. Summary of the invention

[0004] The purpose of the present invention is to overcome the deficiencies of the above-mentioned prior art and provide a composition with instant redness-removing and soothing effects, as well as a preparation method and application thereof, so as to achieve the rapid redness-removing and soothing effects of the product through the synergistic effect of the components in the composition.

[0005] To achieve the above objectives, the technical solutions adopted by the present invention include:

[0006] In a first aspect, the present invention provides a composition with instant redness-removing and soothing effects, the composition comprising the following components in parts by weight: 5-15 parts of scutellaria root extract, 6-18 parts of grapefruit extract, 5-15 parts of rhamnose, and 85-105 parts of cyclodextrin derivatives.

[0007] The main ingredients contained in the Scutellaria root extract, such as baicalin, have good anti-inflammatory and soothing effects, can reduce skin inflammation and vasodilation, help soothe sensitive skin, reduce skin irritation and redness, and have antioxidant properties, which can protect the skin from free radical damage and maintain the stability of the composition.

[0008] Grapefruit extract is rich in natural antioxidants such as flavonoids and vitamin C, which have a good anti-inflammatory effect and help reduce the redness and irritation caused by skin inflammation. Grapefruit extract also has a certain astringent effect, which can help constrict blood vessels, thereby reducing redness of the skin and even out skin tone.

[0009] Rhamnose can help relieve skin inflammation by reducing the release of inflammatory mediators, relieve skin discomfort caused by inflammation, help calm sensitive skin caused by environmental factors (such as wind and sun) or chemical stimulation, and promote skin repair, thereby improving uneven skin tone and redness.

[0010] Cyclodextrin derivatives can encapsulate active ingredients to protect them from oxidation and degradation, thereby improving the stability and effectiveness of the active ingredients. In addition, cyclodextrin derivatives can enhance the skin permeability of anti-inflammatory soothing ingredients, allowing these ingredients to more effectively enter the deep layers of the skin, thereby improving their soothing and anti-inflammatory effects. In addition, cyclodextrin derivatives can improve the texture and sensory experience of the product, making it easier to apply and absorb, and help prevent incompatibility between different ingredients, ensuring the overall stability and effectiveness of the product during use.

[0011] Through experimental research, it was found that the present invention scientifically compounded four components to obtain a composition with instant redness-removing and soothing effects. The four components cooperate with each other and influence each other, which can effectively reduce the hemoglobin EI value of the subject's skin and achieve a rapid redness-removing and soothing effect. There is an obvious synergistic effect between the components. In addition, the composition has good stability, is not easy to oxidize and discolor, has stable and long-lasting activity, and can be widely used in the fields of cosmetics and biomedicine.

[0012] In addition, the inventors explored the dosage of each component and found that when the dosage ratio of the three anti-inflammatory and soothing active ingredients, namely, scutellaria root extract, grapefruit extract, and rhamnose, exceeded the specified range of the present invention, the effect of the prepared composition on reducing the skin hemoglobin EI value was significantly reduced, that is, the redness-removing and soothing effect of the composition decreased, and the stability was also affected to a certain extent, indicating that the above three anti-inflammatory and soothing components can only exert a more ideal synergistic effect when they are within the specified range of the present invention.

[0013] Preferably, the composition comprises the following components in parts by weight: 8-12 parts of scutellaria root extract, 6-15 parts of grapefruit extract, 6-10 parts of rhamnose, and 90-100 parts of cyclodextrin derivatives.

[0014] Preferably, the composition comprises the following components in parts by weight: 10 parts of scutellaria root extract, 10 parts of grapefruit extract, 8 parts of rhamnose, and 95 parts of cyclodextrin derivatives.

[0015] Through experimental research, it was found that when the four components described in the present invention are combined using the optimal dosage ratio specified above, the obtained instant redness-removing and soothing composition has the best redness-removing and soothing effect, and the composition can be effectively absorbed and quickly penetrate into the skin to achieve the therapeutic effect, significantly reduce the hemoglobin EI value of the skin, and achieve an instant repair effect.

[0016] Preferably, the cyclodextrin derivative includes at least one of hydroxypropyl-α-cyclodextrin, hydroxypropyl-β-cyclodextrin and hydroxypropyl-γ-cyclodextrin.

[0017] Preferably, the cyclodextrin derivative is hydroxypropyl-γ-cyclodextrin.

[0018] The inventors have found through a large number of experiments that the addition of hydroxypropyl-γ-cyclodextrin can effectively encapsulate and protect the active ingredients from environmental factors such as oxidation or photolysis, thereby effectively improving the stability of the ingredients. In addition, hydroxypropyl-γ-cyclodextrin can significantly improve the skin permeability of the soothing and anti-inflammatory ingredients of the present invention, so that the prepared composition can more effectively and quickly relieve skin inflammation and sensitivity and improve skin redness.

[0019] In a second aspect, the present invention provides a method for preparing the composition having instant redness-removing and soothing effects, comprising the following steps:

[0020] S1. Dissolve the cyclodextrin derivative in water, add the Scutellaria root extract, adjust the pH to 7.2-7.8, stir and react to obtain a mixed solution;

[0021] S2. Add grapefruit extract to the mixed solution, stir to react, and then filter to obtain a filtrate;

[0022] S3. Add rhamnose to the filtrate, concentrate at 65-75°C until the solid content reaches more than 65%, then vacuum dry, crush and sieve to obtain the composition with instant redness-removing and soothing effects.

[0023] Preferably, in step S1, the stirring reaction time is 1.5-2.5 h; in step S2, the stirring reaction time is 0.5-1.5 h.

[0024] Preferably, in step S2, filtration is performed using a 1-1.5 μm microporous filter membrane; and in step S3, pulverization and screening are performed using a 50-100 mesh sieve.

[0025] In a third aspect, the present invention provides the use of the composition with instant redness-removing and soothing effects in the preparation of cosmetics.

[0026] In a fourth aspect, the present invention provides a cosmetic having instant redness-removing and soothing effects, wherein the cosmetic comprises the composition having instant redness-removing and soothing effects, and the mass percentage of the composition in the cosmetic is 1-5%.

[0027] Compared with the prior art, the present invention has the following beneficial effects:

[0028] The present invention prepares a composition with instant redness-removing and soothing effects by scientifically compounding four components, namely, scutellaria root extract, grapefruit extract, rhamnose, and cyclodextrin derivatives. The four components cooperate with each other and influence each other, and can effectively reduce the hemoglobin EI value of the subject's skin, thereby achieving a rapid redness-removing and soothing effect. The four components have an obvious synergistic effect, and the composition has good stability, is not easy to be oxidized and discolored, has stable and long-lasting activity, and can be widely used in the fields of cosmetics and biomedicine. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] Figure 1 This is the initial picture of a 1% aqueous solution of the composition described in Example 5 under different test conditions;

[0030] Figure 2 These are pictures of a 1% aqueous solution of the composition described in Example 5 after being placed under different test conditions for 3 months. DETAILED DESCRIPTION

[0031] To better illustrate the purpose, technical solutions and advantages of the present invention, the present invention will be further described below in conjunction with specific embodiments. It should be understood by those skilled in the art that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the present invention.

[0032] Unless otherwise specified, all raw materials involved in the following examples and comparative examples are commercially available general materials.

[0033] Examples 1-7

[0034] Table 1: Formula of the composition with instant redness-removing and soothing effect described in Examples 1-7 (parts by weight)

[0035]

[0036] The preparation method of the composition with instant redness-removing and soothing effect described in Examples 1-7 comprises the following steps:

[0037] (1) dissolving the cyclodextrin derivative in water, adding the scutellaria root extract, adjusting the pH to 7.5, and stirring for 2 hours to obtain a mixed solution;

[0038] (2) adding grapefruit extract to the mixed solution, stirring for 1 h, and filtering with a 1.2 μm microporous filter membrane to obtain a filtrate;

[0039] (3) adding rhamnose to the filtrate, concentrating at 70° C. until the solid content reaches more than 65%, vacuum drying, and crushing through an 80-mesh sieve to obtain the composition with instant redness-removing and soothing effects.

[0040] Comparative Examples 1-11

[0041] Table 2: Formula of the composition with instant redness-removing and soothing effect described in Comparative Examples 1-11 (parts by weight)

[0042]

[0043] Comparative Example 12

[0044] This comparative example provides a composition with instant redness-removing and soothing effects, which differs from Example 5 in that the Centella asiatica extract replaces the Scutellaria baicalensis root extract, and the other components and contents remain unchanged.

[0045] Comparative Example 13

[0046] This comparative example provides a composition with instant redness-removing and soothing effects, which differs from Example 5 in that the grapefruit extract is replaced by the calendula extract, and the other components and contents remain unchanged.

[0047] The preparation method of the composition with instant redness-removing and soothing effect described in Comparative Examples 1-13 comprises the following steps:

[0048] (1) dissolving the cyclodextrin derivative in water, adding the Scutellaria baicalensis root extract (or Centella asiatica extract), adjusting the pH to 7.5, and stirring for 2 hours to obtain a mixed solution;

[0049] (2) adding grapefruit extract (or calendula extract) to the mixed solution, stirring for 1 hour, and then filtering with a 1.2 μm microporous filter membrane to obtain a filtrate;

[0050] (3) adding rhamnose to the filtrate, concentrating at 70° C. until the solid content reaches more than 65%, vacuum drying, and crushing through an 80-mesh sieve to obtain the composition with instant redness-removing and soothing effects.

[0051] Effect example

[0052] 1. Safety test:

[0053] The compositions prepared in Examples 1-7 and Comparative Examples 1-13 were used as samples and subjected to safety tests. The specific method is as follows:

[0054] Number of testers: 30 people, 12 males and 18 females, aged 20-60 years old. The volunteers met the selection criteria for subjects in the human skin patch test in the "Technical Specifications for Safety of Cosmetics" (2015 edition).

[0055] Test method: The composition is dissolved in deionized water (the concentration of the composition is 1%) to prepare an aqueous solution, and a patch test is performed. Qualified patch test equipment is selected, and the test substance is placed in the patch tester by a closed patch test method. About 0.020-0.025 ml of the test substance is applied to the curved side of the forearm of the subject with external medical tape, and the test substance is evenly applied to the skin by lightly pressing with the palm of the hand. After 24 hours, the test substance patch tester is removed, and the skin reaction is observed at 0.5, 24, and 48 hours after the removal of the test substance patch tester, and the results are recorded according to the skin reaction grading standard in the "Safety Technical Specifications for Cosmetics" (2015 Edition). Table 3 is the grading standard for adverse skin reactions.

[0056] Table 3

[0057]

[0058]

[0059] The results of the human skin closed patch test showed that there was no positive reaction in 30 people. According to the "Technical Specifications for Safety of Cosmetics" (2015 edition), the test substance will not cause adverse skin reactions in this batch of subjects.

[0060] 2. Redness fading effect test:

[0061] The compositions prepared in Examples 1-7 and Comparative Examples 1-13 were used as samples and tested for red-fading effects. The specific method is as follows:

[0062] 100 male and female volunteers aged 20-60 were selected and divided into 20 groups of 5 people each, and the redness-removing effect of the composition described in Examples 1-7 and Comparative Examples 1-13 of the present invention was tested; the subjects uniformly cleaned the inner forearms of both hands, sat in a laboratory at a temperature of 21±1°C and 50±10%RH for 30 minutes, and then used a far-infrared lamp to irradiate the inner forearms of the subjects' arms for 15 minutes at a distance of 15 cm, and used a skin red pigment test probe Mexameter MX18 to test the skin hemoglobin EI value of the test site, and then used the test sample in the irradiated area, and the usage amount was 5±0.1 mg / cm 2 The test values ​​of each group of volunteers were averaged. The smaller the test value, the lower the skin hemoglobin content. The specific results are shown in Table 4. Among them, T0h refers to after red light irradiation, T1h refers to 1h after using the sample, and T2h refers to 2h after using the sample.

[0063] Table 4

[0064]

[0065]

[0066]

[0067] The results in Table 4 show that the compositions prepared in Examples 1-7 can effectively reduce the elevated hemoglobin content of the skin after red light irradiation, achieve a good rapid redness-removing effect, and effectively alleviate skin sensitivity and redness problems caused by factors such as light. In particular, the composition prepared in Example 5 decreased the hemoglobin EI value of the subject's skin by 25.87% after 1 hour of use, and decreased by 26.81% after 2 hours of use, significantly improving the rapid redness-removing and soothing effect of the composition, avoiding the subject from enduring itching, burning and other irritations, and instantly improving problems such as skin redness and discomfort.

[0068] When any one or two of the three active ingredients of scutellaria root extract, grapefruit extract and rhamnose are missing in Comparative Examples 1-3 and Comparative Examples 5-7, the redness-removing and soothing effect of the obtained composition on the skin is significantly reduced, and the problem of increased skin hemoglobin content caused by light stimulation is not effectively improved. Similarly, when the scutellaria root extract and grapefruit extract are replaced with other conventional anti-inflammatory and soothing ingredients in Comparative Examples 12-13, the redness-removing and soothing effect of the obtained composition is also reduced compared with the embodiment. The above results all show that there is an obvious synergistic effect between the specific components selected by the present invention - scutellaria root extract, grapefruit extract and rhamnose, and the three cooperate with each other to significantly improve the composition. The three components are indispensable for achieving redness-removing and soothing effects and exerting the effects quickly; when the cyclodextrin derivative is missing in Comparative Example 4, the immediate redness-removing effect of the prepared composition is also reduced, indicating that the cyclodextrin derivative also has an important influence on the redness-removing and soothing effect of the composition. The cyclodextrin derivative can effectively improve the skin permeability of the active ingredients, so that the composition can more effectively and quickly relieve skin redness, irritation and other problems; when the dosage ratio of the three anti-inflammatory active ingredients described in Comparative Examples 8-9 exceeds the specified range of the present invention, the rapid redness-removing and soothing effect of the prepared composition is also reduced, indicating that the components of the present invention can better exert a synergistic effect within a specific dosage range, thereby maximizing the rapid redness-removing and soothing effect of the product.

[0069] 3. Soothing effect test:

[0070] 200 subjects were selected, aged 20-45 years old, and the subjects had no serious systemic diseases, no immunodeficiency or autoimmune diseases, no active allergic diseases, no history of allergies to skin care cosmetics, and had not used hormone drugs and immunosuppressants systemically within 1 month. The subjects were divided into 20 groups, 10 people in each group, and the aqueous compositions of Examples 1-7 and Comparative Examples 1-13 of the present invention were tried respectively (the compositions were dissolved in deionized water, and the concentration of the compositions was 1%), and the specific method was as follows:

[0071] The subjects sat quietly for 30 minutes in a constant temperature and humidity environment, where the temperature was 21±1℃ and the humidity was 40-60%. Mark the inner side of the subject's arm about 4 cm 2 Area, absorb 20μL of 2% histamine solution on the marked area, apply it evenly and observe, and those with obvious redness and swelling within 20 minutes are qualified subjects. Each group of 10 subjects applied histamine solution on their arms respectively. When itching and slight redness and swelling occurred, the test substances were applied to the red and swollen areas for testing. The skin changes were observed for 10min, 60min and 90min, and the subjects were asked to score the soothing effect of the composition after 90min, and the average test score of each group was taken; among them, 9-10 points: very good soothing effect for itching and tingling, 7-8 points: good soothing effect for itching and tingling, 5-6 points: average soothing effect for itching and tingling, 3-4 points: poor soothing effect for itching and tingling, 1-2 points: very poor soothing effect for itching and tingling. The specific test results are shown in Table 5.

[0072] Table 5

[0073]

[0074] The results in Table 5 show that the compositions prepared in Examples 1-7 have excellent soothing effects and can effectively reduce the itching and tingling sensations caused by skin irritation, while the compositions prepared in the comparative examples have significantly lower rapid soothing effects than those in the examples.

[0075] 4. Stability test:

[0076] The composition prepared in Example 5 was dissolved in deionized water (composition concentration was 1%), and the solution was clear and transparent. It was then placed at room temperature, pH 5-6, high temperature (45°C), low temperature (4°C), and pH 4-10 for 3 months. The composition of Example 5 was dissolved in 5% butanediol solution (composition concentration was 5%), and placed at room temperature, high temperature (45°C), and pH 4-6 for 3 months to test the stability of the composition.

[0077] Figure 1 For its initial picture, Figure 2This is a picture taken after 3 months of storage. It can be seen from the picture that the aqueous solution has not undergone any obvious color change when placed under different conditions, and no precipitation has been produced. Through the detection and analysis of its content, there is no obvious decrease in the content of active ingredients. It has good stability and can be widely used.

[0078] Finally, it should be noted that the above embodiments are intended to illustrate the technical solution of the present invention rather than to limit the scope of protection of the present invention. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solution of the present invention may be modified or replaced by equivalents without departing from the essence and scope of the technical solution of the present invention.

Claims

1. A composition with instant redness-removing and soothing effects, characterized in that: The composition comprises the following components in parts by weight: 5-15 parts of scutellaria root extract, 6-18 parts of grapefruit extract, 5-15 parts of rhamnose, and 85-105 parts of cyclodextrin derivatives.

2. The composition according to claim 1, characterized in that The composition comprises the following components in parts by weight: 8-12 parts of scutellaria root extract, 6-15 parts of grapefruit extract, 6-10 parts of rhamnose, and 90-100 parts of cyclodextrin derivatives.

3. The composition according to claim 2, characterized in that The composition comprises the following components in parts by weight: 10 parts of scutellaria root extract, 10 parts of grapefruit extract, 8 parts of rhamnose, and 95 parts of cyclodextrin derivatives.

4. The composition according to any one of claims 1 to 3, characterized in that The cyclodextrin derivatives include hydroxypropyl-β-cyclodextrin or hydroxypropyl-γ-cyclodextrin.

5. The composition according to claim 4, characterized in that The cyclodextrin derivative is hydroxypropyl-γ-cyclodextrin.

6. The method for preparing the composition having instant redness-removing and soothing effects according to any one of claims 1 to 5, characterized in that: The following steps are involved: S1. Dissolve the cyclodextrin derivative in water, add the Scutellaria root extract, adjust the pH to 7.2-7.8, stir and react to obtain a mixed solution; S2. Add grapefruit extract to the mixed solution, stir to react, and then filter to obtain a filtrate; S3. Add rhamnose to the filtrate, concentrate at 65-75°C until the solid content reaches more than 65%, then vacuum dry, crush and sieve to obtain the composition with instant redness-removing and soothing effects.

7. The preparation method according to claim 6, characterized in that: In the step S1, the stirring reaction time is 1.5-2.5 hours; in the step S2, the stirring reaction time is 0.5-1.5 hours.

8. The preparation method according to claim 6, characterized in that: In the step S2, 1-1.5 μm microporous filter membrane is used for filtration; in the step S3, 50-100 mesh sieve is used for crushing and screening.

9. Use of the composition with instant redness-removing and soothing effects as claimed in any one of claims 1 to 5 in the preparation of cosmetics.

10. A cosmetic with instant redness-removing and soothing effects, characterized in that: The cosmetic comprises the composition with instant redness-removing and soothing effects as claimed in any one of claims 1 to 5, and the mass percentage of the composition in the cosmetic is 1-5%.

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