Traditional Chinese medicine composition for improving sleep and preparation method thereof

Abstract

The preparation method comprises the following steps: by taking 35-40 parts of spina date seeds, 20-30 parts of poria cocos, 10-15 parts of polygala tenuifolia, 10-15 parts of lucid ganoderma and 0.5-1.5 parts of pearl powder as raw material medicines, carrying out reflux extraction on the spina date seeds with ethanol to obtain a first extracting solution, collecting spina date seed dregs, mixing the poria cocos, the polygala tenuifolia and the lucid ganoderma, adding water, soaking, filtering, and drying to obtain the traditional Chinese medicine composition for improving sleep. And respectively concentrating the first extracting solution and the second extracting solution to obtain dry paste, and uniformly mixing the dry paste with pearl powder to obtain the traditional Chinese medicine active component. The medicine disclosed by the invention has obvious effects of tonifying heart, nourishing liver, calming heart and tranquilizing mind, and the sleep quality is effectively improved by furthest retaining effective components of the medicine and improving the overall sleep-aiding effect of the medicine.

Description

Technical Field

[0001] The invention belongs to the technical field of Chinese medicine preparation, and relates to a Chinese medicine composition with the function of improving sleep, and in particular to a preparation method of the Chinese medicine composition for improving sleep. Background Art

[0002] Sleep plays a very important role in human health. Insomnia refers to a state of persistent unsatisfactory sleep quality, which may even affect daytime social functions in severe cases. Clinical manifestations include difficulty falling asleep, shallow sleep, easy awakening, early awakening, frequent dreams, fatigue after waking up, or lack of wakefulness, alertness, energy, cognitive function, behavioral and emotional changes.

[0003] Sleep disorders have become a modern "fashionable disease". Most people, especially those engaged in mental work, have sleep quality problems, many of which have affected their normal life, seriously endangering people's physical and mental health, and greatly reducing people's quality of life and survival.

[0004] In traditional Chinese medicine, poor sleep quality is called "insomnia" or "restless sleep". It is mostly caused by emotional injury, improper diet, imbalance between work and rest, long-term illness and physical weakness, which lead to organ dysfunction, disharmony of qi and blood, lack of nourishment of the mind, and restlessness. The disease is mainly located in the heart, involving the liver, gallbladder, spleen, stomach, and kidney. The disease is both deficiency and excess, and the deficiency is more than the excess. The treatment principle is to adjust the yin and yang of the organs, nourish qi and blood, calm the mind and calm the nerves, and calm the nerves.

[0005] Currently, most sleep aid products sold on the market are sleeping pills or health foods based on the concept of melatonin. The biggest problem with long-term use of sleeping pills and melatonin is that it is easy to become dependent on them, and eventually you will not be able to sleep without them; at the same time, long-term dependence on drugs leads to an increasing dosage, and the original dosage may no longer be able to solve the insomnia problem well, and may even aggravate depression.

[0006] CN 116898928A relates to a Chinese medicine composition for improving sleep and a preparation method thereof. The composition is prepared from 18-25 parts of pure natural Chinese herbal medicines including 18-25 parts of Chinese jujube seeds, 18-25 parts of Polygala tenuifolia, 12-20 parts of American ginseng, 12-20 parts of Acorus calamus, 8-14 parts of Polygonatum odoratum, 8-14 parts of mulberry, 6-10 parts of white peony root and 6-10 parts of liquorice as raw materials. The composition can effectively improve insomnia and sleep disorders and improve human immunity.

[0007] CN 116712510A provides a pharmaceutical composition for improving sleep quality, a preparation method and application thereof. The pharmaceutical composition comprises, by weight, 90-120 parts of Codonopsis pilosula, 225-300 parts of Polygonum multiflorum vine, 225-300 parts of Albizzia julibrissin bark, 110-150 parts of Ligusticum chuanxiong, 150-200 parts of Semen Ziziphi Spinosae, 75-100 parts of Ophiopogon japonicus, 75-100 parts of Rhizoma Anemarrhenae, 75-100 parts of Longan pulp and 225-300 parts of Triticum tiliaceum. The pharmaceutical composition can comprehensively improve the sleep condition of patients with insomnia of deficiency-cold type and has good safety.

[0008] CN 116585430A A Chinese medicine composition with sleep-improving effect, and its preparation method and application, comprising Chinese jujube seeds, Poria cocos, lily, Huai wheat, jujube, mulberry concentrated juice and strawberry concentrated juice. The preparation method comprises the following steps: crushing Chinese jujube seeds, tuckahoe, lily, Huai wheat, jujube, adding water and boiling for several times, concentrating the filtrate under reduced pressure, mixing the filtrate with mulberry concentrated juice and strawberry concentrated juice, and filtering the mixture through a ceramic membrane to obtain the filtrate.

[0009] CN 115252723A discloses a Chinese medicine composition for resisting fatigue and improving sleep and a preparation method thereof. The composition comprises 10-15 parts by weight of astragalus, 10-15 parts by weight of spinach seeds, 10-15 parts by weight of acanthopanax senticosus, 40-70 parts by weight of wheat germ and 0.5-1 part by weight of beta-cyclodextrin. The different components are mixed and then extracted with water and filtered. The filter residue is subjected to repeated operations. The filtrate is combined and concentrated under reduced pressure and spray-dried to obtain the Chinese medicine composition. The Chinese medicine composition can alleviate the fatigue symptoms of patients, improve the quality of life of patients and reduce medical costs.

[0010] The above-mentioned Chinese medicine compositions for improving sleep quality all use Chinese jujube seeds as the main raw material, and are all made into products of different dosage forms after being extracted with water or alcohol alone and then added with or without auxiliary materials. However, the transfer rate of the effective components of Chinese jujube seeds extracted with water or alcohol alone is not high, which greatly reduces the effect of promoting sleep. Since the effective components of the raw materials are not fully extracted, a larger daily dosage is required to achieve a better effect of promoting sleep, and Chinese jujube seeds are expensive, which increases the burden on consumers and also causes a waste of resources. Summary of the invention

[0011] The purpose of the present invention is to provide a Chinese medicine composition for improving sleep and a preparation method thereof, so as to fully utilize the sleep-promoting effect of the active ingredients of the medicine and improve the sleep quality.

[0012] To achieve the above-mentioned purpose of the invention, the present invention utilizes the theory of traditional Chinese medicine and adds Ganoderma lucidum and pearl powder to the basic formula of traditional Chinese medicine, namely, Chinese jujube seed, Poria cocos and Polygala tenuifolia, so that the formula has obvious effects of nourishing the heart and liver, calming the mind and tranquilizing the nerves, and enhancing the overall sleep-inducing effect of the medicine.

[0013] Specifically, the Chinese medicine composition for improving sleep of the present invention is prepared by the following raw materials in parts by weight: 35-40 parts of Ziziphus jujuba seeds, 20-30 parts of Poria cocos, 10-15 parts of Polygala tenuifolia, 10-15 parts of Ganoderma lucidum, and 0.5-1.5 parts of pearl powder, and is obtained by the following method:

[0014] After crushing the spiny jujube seeds, reflux extraction is performed with ethanol to obtain a first extract, and the spiny jujube seeds residue is collected;

[0015] Mix Poria cocos, Polygala tenuifolia and Ganoderma lucidum, soak in water, add Ziziphus jujuba seed residue, and decoct in water to obtain a second extract;

[0016] The first extract and the second extract are concentrated to obtain a first dry paste and a second dry paste respectively, and then mixed with pearl powder to obtain active components of traditional Chinese medicine.

[0017] Furthermore, in the Chinese medicinal composition for improving sleep of the present invention, the preferred weight proportions of each raw material are 37.5 parts of Ziziphus jujuba seeds, 25 parts of Poria cocos, 12.5 parts of Polygala tenuifolia, 12.5 parts of Ganoderma lucidum, and 1 part of pearl powder.

[0018] The selection and dosage of the above various raw materials are obtained by the inventor after a lot of exploration and summary. Practice has proved that various raw materials have good therapeutic effects within the above weight ranges.

[0019] More specifically, the present invention preferably performs reflux alcohol extraction on the spiny jujube seeds with 80% ethanol solution to obtain the first extract.

[0020] Furthermore, the present invention preferably adds 10 times the amount of 80% ethanol solution and performs reflux extraction for 1 hour.

[0021] Furthermore, the present invention concentrates the first extract to a relative density of 1.20-1.30 g / mL, and then dries to obtain a paste to obtain a first dry paste.

[0022] More specifically, the present invention preferably boils the residues of Poria cocos, Polygala tenuifolia, Ganoderma lucidum and Semen Ziziphi spinosum with water for two times, and combines the filtrates to obtain the second extract.

[0023] Furthermore, in the present invention, the preferred decoction time is 0.5 to 1 hour each time.

[0024] Furthermore, the present invention preferably soaks the Poria cocos, Polygala tenuifolia and Ganoderma lucidum in water for 30 minutes.

[0025] Furthermore, the present invention concentrates the second extract to a relative density of 1.20-1.30 g / mL, and then dries to obtain a paste to obtain a second dry paste.

[0026] The present invention can also adopt conventional preparation methods of Chinese medicine preparations, add pharmaceutically acceptable excipients or carriers to the above-mentioned Chinese medicine active components, and further prepare into any conventional oral dosage form in pharmacy, such as tablets, capsules, granules, pills, mixtures, powders, syrups, oral liquids or decoctions, etc. It is easy to understand that these dosage forms cannot be used to limit the protection scope of the present invention, and it should be emphasized that before preparing any dosage form, the Chinese medicine active components described in the present invention need to be prepared first.

[0027] On the one hand, the present invention utilizes the theory of traditional Chinese medicine, and on the basis of the basic formula of Chinese jujube seeds, Poria cocos and Polygala tenuifolia, by adding Ganoderma lucidum and pearl powder, the whole formula has obvious effects of nourishing the heart and liver, calming the mind and tranquilizing the nerves, and improving the sleep-aiding effect; on the other hand, by the process of single alcohol extraction of the main raw material Chinese jujube seeds, and water extraction after mixing the residue with the other raw materials, the effective ingredients of the medicine are retained to the maximum extent, and compared with the process of water extraction of all raw materials, the content of the effective ingredient (spinosin) is increased by 30%, and animal experiments have proved that the sleep-promoting effect is better than that of the product of water extraction of the raw materials alone, and a good sleep-aiding effect can be achieved when the daily dosage of Chinese jujube seeds is small, and the sleep quality of the user is effectively improved.

[0028] The Chinese medicine composition of the invention is prepared from pure natural plants, is green, safe, and has no toxic side effects when taken for a long time. Implementation

[0029] The specific implementation of the present invention is further described in detail below in conjunction with the examples. The following examples are only used to more clearly illustrate the technical solution of the present invention so that those skilled in the art can well understand and utilize the present invention, but not to limit the protection scope of the present invention.

[0030] The production processes, experimental methods or detection methods involved in the embodiments of the present invention, unless otherwise specified, are all conventional methods in the prior art, and their names and / or abbreviations are all conventional names in the field, and are very clear and unambiguous in the relevant application fields. Technical personnel in the field can understand the conventional process steps based on the names and apply the corresponding equipment, and implement them according to conventional conditions or the conditions recommended by the manufacturer.

[0031] The various instruments, equipment, raw materials or reagents used in the embodiments of the present invention are not particularly limited in terms of their sources, and are all conventional products that can be purchased through regular commercial channels, or can be prepared according to conventional methods well known to those skilled in the art. Example

[0032] Example 1

[0033] Weigh 3.75 kg of spiny jujube seeds, crush them and add them into 10 times the amount of 80% ethanol solvent, reflux and extract for 1 hour, filter to obtain the first extract, and collect the spiny jujube seed residue.

[0034] The first extract is concentrated to a relative density of 1.20-1.30 g / mL, and then dried to a paste containing less than 5% water to obtain a first dry paste.

[0035] Weigh 2.5 kg of Poria cocos, 1.25 kg of Polygala tenuifolia, and 1.25 kg of Ganoderma lucidum, add appropriate amount of water and soak for 30 minutes, then add the collected Ziziphus jujuba seed residue, add 10 times the amount of water and boil for 1 hour, filter and collect the filtrate, boil again under the same conditions, combine the two filtrates to obtain the second extract.

[0036] The second extract is concentrated to a relative density of 1.20-1.30 g / mL, and then dried to a paste containing less than 5% water to obtain a second dry paste.

[0037] Combine the first dry paste and the second dry paste, grind them, add 0.1 kg pearl powder, appropriate amount of microcrystalline cellulose and sodium carboxymethyl starch, mix them evenly, prepare granules with povidone K30 ethanol solution, dry them at 50°C to a moisture content of 3-5%, add appropriate amount of magnesium stearate after granulation, mix them evenly, and press them into tablets to make pharmaceutical tablets with a tablet weight of about 0.8 g / tablet.

[0038] Example 2

[0039] Weigh 3.5 kg of spiny jujube seeds, crush them and add them into 10 times the amount of 80% ethanol solvent, reflux and extract for 1 hour, filter to obtain the first extract, and collect the spiny jujube seed residue.

[0040] The first extract is concentrated to a relative density of 1.20-1.30 g / mL, and then dried to a paste containing less than 5% water to obtain a first dry paste.

[0041] Weigh 3.0 kg of Poria cocos, 1.5 kg of Polygala tenuifolia, and 1.5 kg of Ganoderma lucidum, add appropriate amount of water and soak for 30 minutes, then add the collected Ziziphus jujuba seed residue, add 10 times the amount of water and boil for 1 hour, filter and collect the filtrate, boil again under the same conditions, combine the two filtrates to obtain the second extract.

[0042] The second extract is concentrated to a relative density of 1.20-1.30 g / mL, and then dried to a paste containing less than 5% water to obtain a second dry paste.

[0043] Combine the first dry paste and the second dry paste, grind them, add 0.05 kg pearl powder, appropriate amount of microcrystalline cellulose and sodium carboxymethyl starch, mix them evenly, prepare granules with povidone K30 ethanol solution, dry them at 50°C to a moisture content of 3-5%, add appropriate amount of magnesium stearate after granulation, mix them evenly, and press them into tablets to make pharmaceutical tablets with a tablet weight of about 0.8 g / tablet.

[0044] Example 3

[0045] Weigh 4.0 kg of spiny jujube seeds, crush them and add them into 10 times the amount of 80% ethanol solvent, reflux and extract for 1 hour, filter to obtain the first extract, and collect the spiny jujube seed residue.

[0046] The first extract is concentrated to a relative density of 1.20-1.30 g / mL, and then dried to a paste containing less than 5% water to obtain a first dry paste.

[0047] Weigh 2.0 kg of Poria cocos, 1.0 kg of Polygala tenuifolia, and 1.0 kg of Ganoderma lucidum, add appropriate amount of water and soak for 30 minutes, then add the collected Ziziphus jujuba seed residue, add 10 times the amount of water and boil for 1 hour, filter and collect the filtrate, then add 8 times the amount of water and boil for 40 minutes, combine the two filtrates to obtain the second extract.

[0048] The second extract is concentrated to a relative density of 1.20-1.30 g / mL, and then dried to a paste containing less than 5% water to obtain a second dry paste.

[0049] Combine the first dry paste and the second dry paste, grind them, add 0.15 kg pearl powder, appropriate amount of microcrystalline cellulose and sodium carboxymethyl starch, mix them evenly, prepare granules with povidone K30 ethanol solution, dry them at 50°C to a moisture content of 3-5%, add appropriate amount of magnesium stearate after granulation, mix them evenly, and press them into tablets to make pharmaceutical tablets with a tablet weight of about 0.8 g / tablet.

[0050] Example 4

[0051] Weigh 3.75 kg of spiny jujube seeds, crush them and add them into 10 times the amount of 80% ethanol solvent, reflux and extract for 1 hour, filter to obtain the first extract, and collect the spiny jujube seed residue.

[0052] Weigh 2.5 kg of Poria cocos, 1.25 kg of Polygala tenuifolia, and 1.25 kg of Ganoderma lucidum, add appropriate amount of water and soak for 30 minutes, then add the collected Ziziphus jujuba seed residue, add 10 times the amount of water and boil for 1 hour, filter and collect the filtrate, boil again under the same conditions, combine the two filtrates to obtain the second extract.

[0053] The first extract and the second extract were concentrated to a relative density of 1.02-1.03 g / mL respectively, mixed and centrifuged, the supernatant was taken, 0.1 kg of pearl powder was added, and the mixture was prepared with the dissolved honey and xanthan gum to prepare a drug oral solution.

[0054] Comparative Example 1

[0055] Weigh 3.75 kg of crushed Ziziphus jujuba seeds, 2.5 kg of Poria cocos, 1.25 kg of Polygala tenuifolia, and 1.25 kg of Ganoderma lucidum, add appropriate amount of water to soak for 30 minutes, then add 10 times the amount of water and boil for 1 hour, filter and collect the filtrate, boil again under the same conditions, combine the two filtrates to obtain the extract.

[0056] The extract is concentrated to a relative density of 1.20-1.30 g / mL and dried until the water content is less than 5% to obtain a dry paste.

[0057] After the dry paste is crushed, 0.1 kg of pearl powder, appropriate amount of microcrystalline cellulose and sodium carboxymethyl starch are added and mixed evenly. Granules are prepared with povidone K30 ethanol solution, dried at 50°C to a moisture content of 3-5%. After granulation, an appropriate amount of magnesium stearate is added, mixed evenly and compressed into tablets to make pharmaceutical tablets with a tablet weight of about 0.8 g / tablet.

[0058] Comparative Example 2

[0059] Weigh 3.75 kg of crushed Ziziphus jujuba seeds, 2.5 kg of Poria cocos, and 1.25 kg of Polygala tenuifolia, add appropriate amount of water to soak for 30 minutes, add 10 times the amount of water and boil for 1 hour, filter and collect the filtrate, boil again under the same conditions, combine the two filtrates to obtain the extract.

[0060] The extract is concentrated to a relative density of 1.20-1.30 g / mL and dried until the water content is less than 5% to obtain a dry paste.

[0061] After the dry paste is crushed, appropriate amounts of microcrystalline cellulose and sodium carboxymethyl starch are added and mixed evenly. Granules are prepared with povidone K30 ethanol solution, dried at 50°C to a moisture content of 3-5%. After granulation, appropriate amounts of magnesium stearate are added, mixed evenly, and tableted to form pharmaceutical tablets with a tablet weight of about 0.8 g / tablet.

[0062] Application Example 1

[0063] The sleep-improving Chinese medicine composition tablets prepared in Example 1, Comparative Example 1 and Comparative Example 2 were used to detect the contents of the drug efficacy components jujuboside A and spinosin according to the method specified in the pharmacopoeia. The specific results are listed in Table 1.

[0064]

[0065] It can be seen from Table 1 that the same raw material ratio and different extraction methods have a greater impact on the product efficacy. In Example 1, the jujube seeds are extracted with alcohol alone, and then extracted with other raw materials with water. The contents of the effective ingredients jujube saponin A and spinosaponin are significantly increased.

[0066] Application Example 2

[0067] 120 insomnia patients were selected to conduct a study on the clinical efficacy of the Chinese medicinal composition for improving sleep of the present invention.

[0068] The patients were aged 20 to 60 years old and were randomly divided into three groups, namely, Example 1, Comparative Example 1 and Comparative Example 2, with 40 patients in each group. The three groups of patients took the Chinese medicine composition tablets for improving sleep prepared in Example 1, Comparative Example 1 and Comparative Example 2 before going to bed every day, 6 tablets per day, and observed and recorded the sleep performance of the three groups of patients for a period of 2 months. All patients maintained their original eating habits during the observation period and did not take other Chinese or Western medicines with sleep-aiding effects.

[0069] The sleep condition was divided into three levels, where level A means that the sleep condition was slightly improved, but not obvious; level B means that the sleep condition was improved, relatively obvious; and level C means that the sleep condition was significantly improved. The specific results are shown in Table 2.

[0070]

[0071] According to the clinical trial evaluation of patients, the Chinese medicine composition for improving sleep prepared in Example 1 of the present invention has a significant sleep-inducing effect compared with Comparative Examples 1 and 2, which further proves that at the same dosage, different extraction methods have a greater impact on the efficacy of the drug. In Example 1, the Chinese jujube seeds are extracted with alcohol alone and then extracted with water together with other raw materials. The contents of the effective ingredients Chinese jujube saponin A and spinosaponin are higher, and the sleep-inducing effect is better.

[0072] Application Example 3

[0073] According to the test method of "VI. Helps to improve sleep" in the "Health Food Function Test and Evaluation Method (2023 Edition)", the animal function test of the Chinese medicine composition for improving sleep of the present invention was verified.

[0074] Clean-grade ICR healthy male mice were selected and divided into 2 experimental groups, wherein the first experimental group was subjected to a sodium pentobarbital sleep time experiment, and the second experimental group was subjected to a sodium pentobarbital sleep latency experiment. 48 mice in each experimental group were randomly divided into 4 groups: a blank control group, an embodiment 1 group, a comparative example 1 group, and a comparative example 2 group, with 12 mice in each group.

[0075] The recommended daily dose of the Chinese medicine composition for improving sleep of the present invention is 4.2 g / 60 kg, which is equivalent to 0.07 g / kg BW (adult body weight is 60 kg). The dose is set at 10 times the recommended dose, that is, 0.7 g / kg BW, and prepared at a concentration of 35 mg / mL. Distilled water is set as a blank control group. The animals are weighed daily and orally gavaged at 2.0 mL / 100 g body weight for 30 consecutive days.

[0076] In the first experimental group, 15 min after the last intragastric administration, the animals in each group were intraperitoneally injected with 50 mg kg -1Sodium pentobarbital, injection volume is 0.2mL / 20g, and the disappearance of righting reflex is used as the criterion for falling asleep. Observe whether the test sample can prolong the sodium pentobarbital sleep time.

[0077] In the second experimental group, 280 mg kg -1 Sodium barbital, injection volume is 0.2mL / 20g, and the disappearance of righting reflex is used as an indicator to observe the effect of the test sample on the sleep latency of sodium barbital.

[0078] Table 3 shows the effects of the samples on the sleep time of mice induced by sodium pentobarbital.

[0079]

[0080] Note: Compared with the blank control group, # P <0.05, ## P <0.01; Compared with the comparative example 1 group, * P <0.05; compared with the control group 2, ※ P <0.05.

[0081] The results in Table 3 show that the sleep time of the Example 1 group was significantly longer than that of the Comparative Example 1 group and the Comparative Example 2 group ( P <0.05), indicating that the product of the present invention can well prolong the sleeping time.

[0082] Table 4 shows the effects of the samples on the sleep latency of mice induced by sodium barbital.

[0083]

[0084] Note: Compared with the blank control group, # P <0.05; compared with the comparative example 1 group, * P <0.05; compared with the control group 2, ※ P <0.05.

[0085] The results in Table 4 show that the sleep onset time of the Example 1 group was significantly shorter than that of the Comparative Example 1 group and the Comparative Example 2 group ( P <0.05), indicating that the product of the present invention can significantly reduce the sleep onset latency.

[0086] The above embodiments of the present invention do not describe all the details in detail, nor limit the present invention to the above embodiments. Various changes, modifications, substitutions and variations made by ordinary technicians in this field without departing from the principles and purpose of the present invention should be included in the protection scope of the present invention.

Claims

1. A Chinese medicine composition for improving sleep, which is prepared by the following raw materials in parts by weight: 35-40 parts of Ziziphus jujuba seeds, 20-30 parts of Poria cocos, 10-15 parts of Polygala tenuifolia, 10-15 parts of Ganoderma lucidum, and 0.5-1.5 parts of pearl powder: After crushing the spiny jujube seeds, reflux extraction is performed with ethanol to obtain a first extract, and the spiny jujube seeds residue is collected; Mix Poria cocos, Polygala tenuifolia and Ganoderma lucidum, soak in water, add Ziziphus jujuba seed residue, and decoct in water to obtain a second extract; The first extract and the second extract are concentrated to obtain a first dry paste and a second dry paste respectively, and then mixed with pearl powder to obtain active components of traditional Chinese medicine.

2. The Chinese medicine composition for improving sleep according to claim 1, characterized in that The weight proportions of each raw material medicine are 37.5 parts of Ziziphus jujuba seeds, 25 parts of Poria cocos, 12.5 parts of Polygala tenuifolia, 12.5 parts of Ganoderma lucidum, and 1 part of pearl powder.

3. The Chinese medicinal composition for improving sleep according to claim 1, wherein the first extract is obtained by refluxing the spiny jujube seeds with 80% ethanol solution.

4. The Chinese medicinal composition for improving sleep according to claim 3, characterized in that Add 10 times the amount of 80% ethanol solution and reflux for extraction for 1 h.

5. The Chinese medicinal composition for improving sleep according to claim 1, characterized in that The first extract is concentrated to a relative density of 1.20-1.30 g / mL, and then dried to obtain a first dry paste.

6. The Chinese medicinal composition for improving sleep according to claim 1, characterized in that The residues of Poria cocos, Polygala tenuifolia, Ganoderma lucidum and Semen Ziziphi spinulosus were decocted with water for two times, and the filtrates were combined to obtain the second extract.

7. The Chinese medicinal composition for improving sleep according to claim 6, characterized in that Each decoction takes 0.5 to 1 hour.

8. The Chinese medicinal composition for improving sleep according to claim 1, characterized in that Soak Poria cocos, Polygala tenuifolia and Ganoderma lucidum in water for 30 minutes.

9. The Chinese medicinal composition for improving sleep according to claim 1, characterized in that The second extract is concentrated to a relative density of 1.20-1.30 g / mL, and then dried to obtain a second dry paste.

10. The Chinese medicine composition for improving sleep according to claim 1, characterized in that the obtained Chinese medicine active ingredients are added with pharmaceutically acceptable excipients or carriers to prepare any pharmaceutical oral dosage form, including tablets, capsules, granules, pills, mixtures, powders, syrups, oral liquids or decoctions.

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