Traditional Chinese medicine composition for clearing away lung-heat as well as preparation method and application of traditional Chinese medicine composition

Abstract

The invention discloses a lung-heat-clearing traditional Chinese medicine composition as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition for clearing away the lung-heat is prepared from the following raw materials in parts by weight: 1-50 parts of rhizoma polygonati, 1-40 parts of herba houttuyniae, 1-50 parts of radix platycodonis, 1-40 parts of semen lepidii, 1-50 parts of radix astragali, 1-40 parts of rhizoma acori graminei, 1-30 parts of radix stephaniae tetrandrae, 1-40 parts of radix saposhnikoviae, 1-30 parts of radix codonopsis, 1-30 parts of lotus plumule, 1-50 parts of fructus momordicae and 1-50 parts of loofah sponge. The traditional Chinese medicine composition disclosed by the invention has the effects of clearing away lung-heat and detoxifying, preventing phlegm from forming and stopping coughing, purging lung and relieving asthma, and reinforcing qi and nourishing yin, can promote lung dredging and make the lung smooth, and has a good treatment effect on lung infectious diseases caused by novel coronavirus, influenza A virus, mycoplasma and the like.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicine compositions, and in particular relates to a lung-clearing traditional Chinese medicine composition and a preparation method and application thereof. Background Art

[0002] The lung is an important respiratory organ of the human body. It is one of the five internal organs in traditional Chinese medicine and has the function of regulating the whole body's qi, blood, and body fluid. The lung is vulnerable to a variety of external factors, infections by pathogens such as bacteria, viruses, fungi, parasites, and the influence of physical and chemical factors, immune problems, and drugs, which can cause lung infection. The most prominent symptoms of lung infection are changes in body temperature, cough, and increased sputum. At present, Western medicine mainly uses antibacterial or antiviral drugs for the treatment of pulmonary infectious diseases. Although these drugs have a certain effect on pulmonary infection, such drugs, especially antibacterial drugs, are prone to drug resistance and have more side effects. Chinese medicine is regarded as an important treatment method due to its wide source of raw materials, safety and no side effects. Therefore, it is particularly important to provide a Chinese medicine composition that can promote lung silt removal, make the lungs transparent and unobstructed, and effectively prevent and treat various pulmonary infectious diseases. Summary of the invention

[0003] In view of this, the purpose of the present invention is to provide a lung-clearing Chinese medicine composition, which has the effects of clearing the lungs and detoxifying, resolving phlegm and relieving cough, purging the lungs and relieving asthma, and invigorating qi and nourishing yin, and can effectively prevent and / or treat lung infectious diseases, and is safe and has no side effects.

[0004] Another object of the present invention is to provide a method for preparing the traditional Chinese medicine composition.

[0005] Another object of the present invention is to provide an application of the traditional Chinese medicine composition in the preparation of therapeutic drugs.

[0006] Another object of the present invention is to provide a drug for treatment.

[0007] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0008] The invention provides a lung-clearing Chinese medicine composition, which comprises the following raw materials in parts by weight: 1-50 parts of polygonatum, 1-40 parts of houttuynia cordata, 1-50 parts of platycodon, 1-40 parts of leonuri seeds, 1-50 parts of astragalus, 1-40 parts of calamus, 1-30 parts of tertium, 1-40 parts of siler, 1-30 parts of codonopsis, 1-30 parts of lotus seed core, 1-50 parts of momordica grosvenori and 1-50 parts of luffa.

[0009] Preferably, the Chinese medicine composition comprises the following raw materials in parts by weight: 12-36 parts of polygonatum, 8-20 parts of houttuynia cordata, 12-29 parts of platycodon, 9-21 parts of lepidium scabra, 15-30 parts of astragalus, 12-18 parts of calamus, 12-18 parts of stephania tetrandra, 12-24 parts of siler, 6-18 parts of codonopsis pilosula, 6-18 parts of lotus seed core, 16-24 parts of momordica grosvenori and 18-32 parts of luffa.

[0010] The present invention also provides a method for preparing the traditional Chinese medicine composition, comprising the following steps: weighing the raw materials respectively, mixing, decocting with water, filtering, and collecting the filtrate.

[0011] Preferably, the decoction time is 20 to 60 minutes.

[0012] The present invention also provides an application of the traditional Chinese medicine composition in preparing medicines for preventing and / or treating pulmonary infectious diseases.

[0013] Preferably, the pulmonary infectious disease includes pneumonia, lung cysts or tuberculosis.

[0014] Preferably, the pneumonia includes viral pneumonia, bacterial pneumonia, fungal pneumonia or mycoplasma pneumonia.

[0015] Preferably, the virus in the viral pneumonia includes a new coronavirus, influenza virus, coxsackie virus or adenovirus.

[0016] The present invention also provides a medicine for preventing and / or treating pulmonary infectious diseases, which comprises the Chinese medicine composition and pharmaceutically acceptable excipients.

[0017] Preferably, the pharmaceutical dosage form includes decoction, pill, powder, paste, granule, oral liquid, capsule or tablet.

[0018] Beneficial effects of the present invention:

[0019] The invention provides a lung-clearing Chinese medicine composition and a preparation method and application thereof. The Chinese medicine composition uses polygonatum and houttuynia cordata as main medicines, platycodon, scutellaria baicalensis and astragalus as assistant medicines, calamus, stephania tetrandra and siler as adjuvant medicines, and codonopsis pilosula, lotus seed core, momordica grosvenori and luffa as guiding medicines. All the medicines are used together to achieve the effects of clearing the lungs and detoxifying, resolving phlegm and relieving cough, purging the lungs and relieving asthma, and invigorating qi and nourishing yin. The present invention uses lung clearing and detoxification, phlegm and cough relieving as a method of treating the symptoms, quickly relieves the symptoms such as heat toxicity and phlegm dampness in the lungs, uses Qi-invigorating and Yin-nourishing as a fundamental solution, restores the normal physiological function of the lungs, enhances the body's resistance, prevents disease recurrence, and achieves both symptomatic and fundamental treatment; while using heat-clearing and detoxifying and other evil-eliminating drugs, it focuses on using astragalus, Codonopsis and other strengthening drugs, so that the evil is removed without injury, and the body's ability to resist evil is enhanced by strengthening the body, achieving the purpose of eliminating evil; the prescription has cold and warm drugs, and through reasonable compatibility, the drugs are prevented from being too cold or warm, so that the medicinal properties of the prescription tend to be peaceful, and adverse effects on the body are avoided. The Chinese medicine composition of the present invention has the effects of lung clearing and detoxification, phlegm-resolving and cough relieving, lung purging and asthma-relieving, Qi-invigorating and Yin-nourishing, can promote lung silt removal, make the lungs transparent and unobstructed, and has a good therapeutic effect for pulmonary infectious diseases caused by including new coronavirus, influenza A virus, mycoplasma, etc. DETAILED DESCRIPTION

[0020] The invention provides a lung-clearing Chinese medicine composition, which comprises the following raw materials in parts by weight: 1-50 parts of polygonatum, 1-40 parts of houttuynia cordata, 1-50 parts of platycodon, 1-40 parts of leonuri seeds, 1-50 parts of astragalus, 1-40 parts of calamus, 1-30 parts of tertium, 1-40 parts of siler, 1-30 parts of codonopsis, 1-30 parts of lotus seed core, 1-50 parts of momordica grosvenori and 1-50 parts of luffa.

[0021] In the present invention, the houttuynia cordata is cold in nature, pungent in taste, belongs to the lung meridian, has the effects of clearing away heat and detoxifying, eliminating carbuncle and draining pus, and promoting diuresis and relieving stranguria, and is the main drug in the prescription. Houttuynia cordata can directly reduce the heat toxins in the lungs, and has significant therapeutic effects on symptoms such as fever, cough, and coughing up pus and blood caused by heat toxins in the lungs. The weight portion of the houttuynia cordata is further preferably 8 to 20 parts, and more preferably 12 to 18 parts. The present invention has no special limitation on the source of houttuynia cordata, and it can be purchased through conventional commercial channels.

[0022] In the present invention, the polygonatum is flat in nature, sweet in taste, and enters the spleen, lung, and kidney meridians. It has the effects of replenishing qi and nourishing yin, strengthening the spleen, moistening the lungs, and benefiting the kidneys, and is the main medicine in the prescription. In the process of clearing the lungs, the lung yin is easily damaged by the evil of fire and heat. The polygonatum can nourish the lung yin and prevent the excessive consumption of the lung yin. At the same time, it provides a material basis for the recovery of lung qi. It is compatible with houttuynia cordata, one clearing and one supplementing, and synergistically plays a key role in clearing the lungs and strengthening the body. The weight portion of the polygonatum is further preferably 12 to 36 parts, and more preferably 18 to 26 parts. The present invention does not specifically limit the source of the polygonatum, and it can be purchased through conventional commercial channels.

[0023] In the present invention, the Platycodon grandiflorum is flat in nature, bitter and pungent in taste, and enters the lung and stomach meridians. It has the effects of opening and dispersing lung qi, removing phlegm and discharging pus, and is the minister drug in the prescription. Platycodon grandiflorum is good at dispersing lung qi and removing phlegm, and assists the monarch drug in playing the effects of clearing heat and moistening the lungs. At the same time, its expectorant power can assist in discharging phlegm produced by heat toxicity in the lungs, and enhance the expectorant and cough relieving effects of the prescription. The Platycodon grandiflorum weight portion is further preferably 12 to 29 parts, and more preferably 16 to 26 parts. The present invention has no particular limitation on the source of Platycodon grandiflorum, and it can be purchased conventionally through commercial channels.

[0024] In the present invention, the scutellaria baicalensis is cold in nature, bitter in taste, belongs to the lung and bladder meridians, has the effect of descending qi and promoting water circulation, and is the minister drug in the prescription. Scutellaria baicalensis can alleviate the symptoms of lung qi reversal by purging the lungs, and its diuretic effect also helps to eliminate the abnormal water metabolism caused by lung heat, and assists the monarch drug to improve the heat and stagnation state of the lungs. The weight portion of the scutellaria baicalensis is further preferably 9 to 21 parts, and more preferably 12 to 18 parts. The present invention does not specifically limit the source of the scutellaria baicalensis, and it can be purchased through conventional commercial channels.

[0025] In the present invention, the astragalus is warm in nature, sweet in taste, and belongs to the lung and spleen meridians. It has the effects of replenishing qi and strengthening the exterior, supporting toxins and draining pus, diuresis, and promoting tissue regeneration, and is a ministerial medicine in the prescription. In the process of clearing the lungs, astragalus can prevent damage to the vital energy due to excessive heat clearing, while enhancing the body's resistance, helping the body to resist exogenous evil, and assisting the polygonatum in the monarch medicine to restore lung qi, so that the lung qi is abundant and the expelling evil is powerful. The weight portion of the astragalus is further preferably 15 to 30 parts, and more preferably 18 to 26 parts. The present invention does not specifically limit the source of the astragalus, and it can be purchased conventionally through commercial channels.

[0026] In the present invention, the Acorus calamus is slightly warm in nature, pungent in taste, and enters the mouth, liver, and spleen meridians. It has the effects of opening the mind, removing phlegm, regulating qi, promoting blood circulation, dispersing wind, and removing dampness, and is an adjuvant in the prescription. The phlegm-removing effect of Acorus calamus can assist phlegm-removing drugs such as Platycodon grandiflorum to enhance the power of removing phlegm, and since some drugs in the prescription are cold, the warm nature of Acorus calamus can prevent the cold drugs from excessively damaging the yang qi of the spleen and stomach. The weight portion of the Acorus calamus is further preferably 12 to 18 parts, and more preferably 13 to 17 parts. The present invention has no special limitation on the source of Acorus calamus, and it can be purchased through conventional commercial channels.

[0027] In the present invention, the Stephania tetrandra is cold in nature, bitter in taste, and enters the bladder, spleen, and kidney meridians. It has the effects of promoting water flow and purging dampness and heat in the lower jiao, and is an adjuvant in the prescription. Stephania tetrandra can assist heat-clearing drugs such as Houttuynia cordata to strengthen the heat-clearing effect. At the same time, its diuretic effect helps to clear the dampness and evil in the lungs, alleviate the symptoms of lung heat, and prevent the retention of dampness and internal heat caused by heat toxins, and cooperate with other drugs to improve the pathological state of the lungs. The weight portion of Stephania tetrandra is further preferably 12 to 18 parts, and more preferably 13 to 17 parts. The present invention does not specifically limit the source of Stephania tetrandra, and it can be purchased through conventional commercial channels.

[0028] In the present invention, the siler is warm in nature, pungent and sweet in taste, and is in the bladder, lung, and spleen meridians. It has the effects of releasing wind, removing dampness, and relieving pain, and is an adjuvant in the prescription. The siler can assist the smooth flow of lung qi and prevent external wind from invading the lungs. At the same time, its slightly warm nature can restrict the coldness of some drugs, play a role in reconciling the properties of the drugs, and has an auxiliary therapeutic effect on symptoms such as cough caused by wind evil invading the lungs. The siler weight portion is further preferably 12 to 24 parts, and more preferably 14 to 20 parts. The present invention does not specifically limit the source of the siler, and it can be purchased through conventional commercial channels.

[0029] In the present invention, the Codonopsis pilosula is flat in nature, sweet in taste, and enters the spleen and lung meridians. It has the effects of tonifying the middle, replenishing qi, and promoting the production of body fluids, and is a medicine in the prescription. Codonopsis pilosula can make the various drugs cooperate with each other and exert better drug effects. At the same time, its function of strengthening the spleen and lungs helps to enhance the spleen and stomach transportation and transformation, so that the drugs are better absorbed and utilized, thereby better acting on the lungs. The weight portion of the Codonopsis pilosula is further preferably 6 to 18 parts, and more preferably 8 to 15 parts. The present invention has no special limitation on the source of Codonopsis pilosula, and it can be purchased through conventional commercial channels.

[0030] In the present invention, the lotus seed heart is cold in nature, bitter in taste, and enters the heart and kidney meridians, and has the effects of clearing the heart, removing heat, stopping bleeding, and astringing semen, and is a medicine in the prescription. The lotus seed heart can guide the medicine to enter the heart, and indirectly exerts an effect on the lungs through the mutual connection between the heart and the lungs. The weight portion of the lotus seed heart is further preferably 6 to 18 parts, and more preferably 8 to 15 parts. The present invention has no special limitation on the source of the lotus seed heart, and it can be purchased through conventional commercial channels.

[0031] In the present invention, the Momordica grosvenori is cool in nature, sweet in taste, and belongs to the lung and large intestine meridians, and has the effect of clearing the lungs and moistening the intestines, and is the medicine in the prescription. Momordica grosvenori can guide the drug to act on the lung meridian, enhance the effect of the prescription in clearing heat and moistening the lungs, and at the same time, its sweet taste can improve the taste of the prescription, which is conducive to the taking of the drug. The weight portion of the Momordica grosvenori is further preferably 16 to 24 parts, and more preferably 18 to 22 parts. The present invention has no special limitation on the source of Momordica grosvenori, and it can be purchased through conventional commercial channels.

[0032] In the present invention, the luffa is mild in nature, sweet in taste, and enters the lung, stomach, and liver meridians. It has the effects of promoting blood circulation, clearing away heat and resolving phlegm, and is the adjuvant in the prescription. The luffa plays the role of guiding the meridians and dredging the collaterals, so that the medicine can reach the lungs better, play the role of clearing the lungs and dredging the collaterals, promote the smooth flow of qi and blood in the lungs, and ensure the smooth play of the drug effect. The weight portion of the luffa is further preferably 18 to 32 parts, and more preferably 22 to 28 parts. The present invention has no special limitation on the source of the luffa, and it can be purchased through conventional commercial channels.

[0033] In the present invention, polygonatum and houttuynia cordata are used as the main drugs, platycodon, scutellaria baicalensis and astragalus are used as the assistant drugs, calamus, stephania tetrandra and siler are used as the adjuvant drugs, and codonopsis pilosula, lotus seed core, momordica grosvenori and luffa are used as the guiding drugs. All the drugs are used together to play the functions of clearing the lungs and detoxifying, resolving phlegm and relieving cough, purging the lungs and relieving asthma, and invigorating qi and nourishing yin. The present invention uses lung-clearing and detoxifying, phlegm-resolving and cough-relieving methods to treat the symptoms, quickly relieves symptoms such as heat toxicity, phlegm and dampness in the lungs, uses qi-invigorating and yin-nourishing methods to treat the root causes, restores the normal physiological function of the lungs, enhances the body's resistance, prevents recurrence of the disease, and achieves both symptomatic and root treatment; while using heat-clearing and detoxifying and other evil-eliminating drugs, it focuses on using astragalus, codonopsis and other strengthening drugs to eliminate the evil without hurting the body, and enhances the body's ability to resist the evil by strengthening the body, so as to achieve the purpose of eliminating the evil; the medicines in the prescription are both cold and warm, and through reasonable compatibility, the medicines are prevented from being too cold or too warm, so that the medicinal properties of the prescription tend to be peaceful, and adverse effects on the body are avoided.

[0034] The present invention also provides a method for preparing the traditional Chinese medicine composition, comprising the following steps: weighing the raw materials respectively, mixing, boiling with water, filtering, and collecting the filtrate.

[0035] In the present invention, in the decoction with water, the mass ratio of the raw material to water is preferably 1:5-15, more preferably 1:8 or 1:6-8 or 1:8-10; the decoction time is preferably 20-60 min, more preferably 35 min or 30-35 min or 35-45 min; the number of decoctions is preferably 1-4 times, more preferably 2-3 times.

[0036] In the present invention, the preparation method preferably further comprises: after mixing the raw materials, soaking them in water and then boiling them; the mass ratio of the raw materials to water is preferably 1:5-15, more preferably 1:8 or 1:6-8 or 1:8-10; the soaking time is preferably 15-60 minutes, more preferably 30 minutes or 20-30 minutes or 30-40 minutes. After the soaking, boiling is performed. The boiling operation is the same as above.

[0037] In the present invention, after decoction, conventional methods can be selected according to actual needs to filter and collect the filtrate; if decoction is performed multiple times, the collected filtrates can be combined.

[0038] The present invention also provides an application of the traditional Chinese medicine composition in preparing medicines for preventing and / or treating pulmonary infectious diseases.

[0039] In the present invention, the Chinese medicine composition has the effects of clearing the lungs and detoxifying, resolving phlegm and relieving cough, purging the lungs and relieving asthma, and replenishing qi and nourishing yin, and can effectively treat pulmonary infectious diseases. In the present invention, the pulmonary infectious diseases preferably include pneumonia, lung cysts or tuberculosis; the pneumonia preferably includes viral pneumonia, bacterial pneumonia, fungal pneumonia or mycoplasma pneumonia; the virus in the viral pneumonia preferably includes a new coronavirus, influenza virus, coxsackie virus or adenovirus. The medicine may contain only one active ingredient of the Chinese medicine composition, or may contain other active ingredients that can treat pulmonary infectious diseases.

[0040] The present invention also provides a medicine for preventing and / or treating pulmonary infectious diseases, which comprises the Chinese medicine composition and pharmaceutically acceptable excipients.

[0041] In the present invention, there is no special limitation on the dosage form of the drug, which can be conventionally selected according to actual needs, including but not limited to decoctions, pills, powders, pastes, granules, oral liquids, capsules or tablets. The excipients can be conventionally selected according to the drug dosage form, including but not limited to one or more of stabilizers, adhesives, regulators, cosolvents, preservatives, surfactants, colorants or sweeteners. In the drug, the content of the Chinese medicine composition can be conventionally selected according to actual needs, for example, the content of the Chinese medicine composition of the present invention can be 0.01% to 100%. The mode of administration of the drug of the present invention can be conventionally selected according to actual needs, preferably oral or injection; the dosage of the drug can be conventionally selected according to actual needs, for example, the dosage of the drug is 0.01μg to 100g / d.

[0042] The technical solutions provided by the present invention are described in detail below in conjunction with the embodiments, but they should not be construed as limiting the protection scope of the present invention.

[0043] In the following embodiments, unless otherwise specified, all of them are conventional methods.

[0044] Unless otherwise specified, the materials and reagents used in the following examples can be obtained from commercial sources.

[0045] Example 1

[0046] A lung-clearing Chinese medicine composition is prepared from the following raw materials in parts by weight:

[0047] 12 parts of polygonatum, 8 parts of houttuynia, 12 parts of platycodon, 9 parts of scutellaria, 15 parts of astragalus, 12 parts of calamus, 12 parts of terrestris, 12 parts of siler, 6 parts of codonopsis, 6 parts of lotus seed core, 16 parts of momordica and 18 parts of luffa.

[0048] The preparation method of the Chinese medicine composition comprises the following steps:

[0049] Weigh each raw material according to the above weight portion, mix, soak in water, the mass ratio of raw material to water is 1:5, soak for 60 minutes, decoct for 20 minutes, filter, collect the filtrate, repeat the decoction 4 times, and combine the filtrates of the 4 decoctions.

[0050] Example 2

[0051] A lung-clearing Chinese medicine composition is prepared from the following raw materials in parts by weight:

[0052] 36 parts of polygonatum, 20 parts of houttuynia, 29 parts of platycodon, 21 parts of leucophylla, 30 parts of astragalus, 18 parts of calamus, 18 parts of terrestris, 24 parts of siler, 18 parts of codonopsis, 18 parts of lotus seed core, 24 parts of momordica and 32 parts of luffa.

[0053] The preparation method of the Chinese medicine composition comprises the following steps:

[0054] Weigh each raw material drug according to the above weight portion, mix, soak in water, the mass ratio of raw material drug to water is 1:15, soak for 15 minutes, boil for 60 minutes, filter, and collect the filtrate.

[0055] Example 3

[0056] A lung-clearing Chinese medicine composition is prepared from the following raw materials in parts by weight:

[0057] 18 parts of polygonatum, 12 parts of houttuynia, 16 parts of platycodon, 12 parts of leucophylla, 18 parts of astragalus, 13 parts of calamus, 13 parts of terrestris, 14 parts of siler, 8 parts of codonopsis, 8 parts of lotus seed core, 18 parts of momordica and 22 parts of luffa.

[0058] The preparation method of the Chinese medicine composition comprises the following steps:

[0059] Weigh each raw material according to the above weight portion, mix, soak in water, the mass ratio of raw material to water is 1:6, soak for 40 minutes, decoct for 30 minutes, filter, collect the filtrate, repeat the decoction 3 times, and combine the filtrates of the 3 decoctions.

[0060] Example 4

[0061] A lung-clearing Chinese medicine composition is prepared from the following raw materials in parts by weight:

[0062] 26 parts of polygonatum, 18 parts of houttuynia, 24 parts of platycodon, 17 parts of lepidium, 25 parts of astragalus, 17 parts of calamus, 17 parts of terrestris, 20 parts of siler, 15 parts of codonopsis, 15 parts of lotus seed core, 22 parts of momordica and 26 parts of luffa.

[0063] The preparation method of the Chinese medicine composition comprises the following steps:

[0064] Weigh each raw material according to the above weight portion, mix, soak in water, the mass ratio of raw material to water is 1:10, soak for 20 minutes, decoct for 45 minutes, filter, collect the filtrate, repeat the decoction twice, and combine the filtrates of the two decoctions.

[0065] Example 5

[0066] A lung-clearing Chinese medicine composition is prepared from the following raw materials in parts by weight:

[0067] 24 parts of polygonatum, 14 parts of houttuynia, 20 parts of platycodon, 15 parts of leucophylla, 22 parts of astragalus, 15 parts of calamus, 15 parts of terrestris, 18 parts of siler, 12 parts of codonopsis, 12 parts of lotus seed core, 20 parts of momordica and 25 parts of luffa.

[0068] The preparation method of the Chinese medicine composition comprises the following steps:

[0069] Weigh each raw material according to the above weight portion, mix, soak in water, the mass ratio of raw material to water is 1:8, soak for 30 minutes, decoct for 35 minutes, filter, collect the filtrate, repeat the decoction 3 times, and combine the filtrates of the 3 decoctions.

[0070] Comparative Example 1

[0071] A Chinese medicine composition is prepared from the following raw materials in parts by weight:

[0072] 24 parts of polygonatum, 14 parts of scutellaria, 20 parts of platycodon, 15 parts of leucophylla, 22 parts of astragalus, 15 parts of calamus, 15 parts of fangji, 18 parts of siler, 12 parts of codonopsis, 12 parts of lotus seed core, 20 parts of momordica and 25 parts of luffa.

[0073] Preparation method of the Chinese medicine composition: The preparation method of this comparative example is the same as that of Example 5 except that the composition of the Chinese medicine raw materials of the Chinese medicine composition is different, and the other steps are the same.

[0074] Comparative Example 2

[0075] A Chinese medicine composition is prepared from the following raw materials in parts by weight:

[0076] 24 parts of polygonatum, 14 parts of houttuynia, 20 parts of platycodon, 15 parts of ephedra, 22 parts of astragalus, 15 parts of calamus, 15 parts of fangji, 18 parts of siler, 12 parts of codonopsis, 12 parts of lotus seed core, 20 parts of momordica and 25 parts of luffa.

[0077] Preparation method of the Chinese medicine composition: The preparation method of this comparative example is the same as that of Example 5 except that the composition of the Chinese medicine raw materials of the Chinese medicine composition is different, and the other steps are the same.

[0078] Comparative Example 3

[0079] A Chinese medicine composition is prepared from the following raw materials in parts by weight:

[0080] 24 parts of polygonatum, 14 parts of houttuynia, 20 parts of platycodon, 15 parts of scutellaria, 22 parts of astragalus, 15 parts of thunbergii, 15 parts of coptis, 18 parts of siler, 12 parts of codonopsis, 12 parts of lotus seed core, 20 parts of momordica and 25 parts of liquorice.

[0081] Preparation method of the Chinese medicine composition: The preparation method of this comparative example is the same as that of Example 5 except that the composition of the Chinese medicine raw materials of the Chinese medicine composition is different, and the other steps are the same.

[0082] Test Example 1

[0083] 1. General information: 150 patients with pneumonia caused by the new coronavirus, aged between 18 and 65 years old, were selected and randomly divided into 5 groups (positive control group, control group 1, control group 2, control group 3 and experimental group), with 30 people in each group.

[0084] 2. Diagnostic criteria: Refer to the diagnostic criteria and clinical classification of pneumonia caused by the new coronavirus.

[0085] 3. Inclusion criteria: Meet the diagnostic criteria and clinical classification is common type.

[0086] 4. Exclusion criteria: patients with other severe primary lung diseases, pregnant or lactating women, patients with severe primary cardiovascular, liver, kidney and hematopoietic system diseases and mental disorders, and patients with drug allergies were excluded.

[0087] 5. Treatment method: The positive control group orally took Jinhua Qinggan Granules, 5 g per bag, 1 bag at a time, 3 times a day; the control groups 1-3 orally took the Chinese medicine compositions prepared by comparative examples 1-3, 1 dose per day, 500 mL per dose, taken in 2 times; the experimental group orally took the Chinese medicine composition prepared by Example 5, 1 dose per day, 500 mL per dose, taken in 2 times.

[0088] 6. Criteria for judging the efficacy: Based on clinical symptoms such as fever, dry cough, fatigue, nasal congestion, runny nose, sore throat, myalgia, diarrhea, and lung imaging lesions, refer to the efficacy evaluation criteria for wind-heat lung heat disease in the "Standards for Diagnosis and Efficacy of Traditional Chinese Medicine Diseases":

[0089] (1) Cure: symptoms and signs disappear, and lung imaging shows significant improvement of acute exudative lesions;

[0090] (2) Improvement: symptoms and signs, and lung imaging examinations have improved, and lung imaging shows that lung lesions have not been completely absorbed;

[0091] (3) Not cured: The condition has not improved.

[0092] After 7 days of treatment, the number of cured, improved, and uncured patients in each group was counted; viral nucleic acid testing was performed every day at the beginning of treatment until the nucleic acid test was negative for two consecutive times, and the time when the nucleic acid turned negative for the first time in two consecutive times was recorded for each group.

[0093] 7. Treatment effect

[0094] Table 1 Treatment effect

[0095]

[0096] As can be seen from the results in Table 1, the effective rate of the Chinese medicine composition of the present invention for the treatment of common pneumonia patients caused by the new coronavirus reached 96.67%, which was 26.09% higher than that of the positive control group; the 30 patients in the experimental group all turned negative in 5-10 days of nucleic acid testing, and the average negative time was 8.93 days, which was 19.37% shorter than that of the positive control group; and during the treatment of the Chinese medicine composition of the present invention, none of the 30 patients had adverse drug reactions, while 6 patients in the positive group reported the occurrence or aggravation of diarrhea and abdominal pain. Control groups 1-3 changed individual medicinal flavors on the basis of the Chinese medicine composition of the present invention, and their effective rates decreased significantly, the nucleic acid negative time increased significantly, and 3 patients in control group 3 reported gastrointestinal discomfort symptoms. It can be seen from this that the medicinal flavors of the Chinese medicine composition of the present invention cooperate with each other, synergize and enhance, and jointly achieve the effect of treating pneumonia caused by the new coronavirus.

[0097] Test Example 2

[0098] Typical cases:

[0099] Case 1: Chen, male, 25 years old, had a body temperature of more than 39°C for 5 consecutive days, cough, fatigue, muscle aches all over the body, diarrhea, and was diagnosed with influenza A virus pneumonia. He took the Chinese medicine composition of Example 2 of the present invention, 1 dose per day, 1 dose of 600 mL, divided into 3 doses, and his body temperature dropped to below 38°C after 2 days, and symptoms such as cough were relieved. After taking it for 5 more days, the symptoms disappeared and did not recur.

[0100] Case 2: Lin, female, 28 years old, influenza A virus combined with mycoplasma infection, chest X-ray examination showed pneumonia lesions, and the main symptoms were fever, cough, and sore throat. Taking the Chinese medicine composition of Example 4 of the present invention, 1 dose per day, 1 dose of 600 mL, divided into 2 doses, the symptoms were relieved after 3 days, and the cough was significantly relieved. After continuing to take the medicine for 7 days, the symptoms completely disappeared and did not recur.

[0101] Case 3: Chen, male, 51 years old, was diagnosed with pneumonia caused by the new coronavirus before. After the nucleic acid turned negative, he still coughed and expectorated, and the cough worsened at night and after getting up in the morning. The symptoms lasted for more than 2 months. Take the Chinese medicine composition of Example 3 of the present invention, 1 dose per day, 1 dose of 500mL, divided into 2 doses, and the cough symptoms were significantly alleviated after 3 days. After continuing to take it for 11 days, the symptoms basically disappeared, only occasionally coughing at night, and continuing to take it for 7 days, the symptoms completely disappeared, and there was no recurrence thereafter.

[0102] It can be seen from the above results that the Chinese medicine composition of the present invention has the effects of clearing the lungs and detoxifying, resolving phlegm and relieving cough, purging the lungs and relieving asthma, and invigorating qi and nourishing yin. It has a good therapeutic effect on lung infectious diseases caused by factors including the new coronavirus, influenza A virus, mycoplasma, etc.

[0103] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A lung-clearing Chinese medicine composition, characterized in that: The Chinese medicine composition comprises the following raw materials in parts by weight: 1-50 parts of polygonatum, 1-40 parts of houttuynia cordata, 1-50 parts of platycodon, 1-40 parts of leonuri seeds, 1-50 parts of astragalus, 1-40 parts of calamus, 1-30 parts of terrestris, 1-40 parts of siler, 1-30 parts of codonopsis pilosula, 1-30 parts of lotus seed core, 1-50 parts of momordica grosvenori and 1-50 parts of luffa.

2. The Chinese medicine composition according to claim 1, characterized in that: The Chinese medicine composition comprises the following raw materials in parts by weight: 12-36 parts of polygonatum, 8-20 parts of houttuynia cordata, 12-29 parts of platycodon, 9-21 parts of scutellaria baicalensis, 15-30 parts of astragalus, 12-18 parts of calamus, 12-18 parts of terrestris, 12-24 parts of siler, 6-18 parts of codonopsis pilosula, 6-18 parts of lotus seed core, 16-24 parts of momordica grosvenori and 18-32 parts of luffa.

3. The method for preparing the Chinese medicine composition according to any one of claims 1 to 2, characterized in that: The method comprises the following steps: weighing the raw materials respectively, mixing, boiling with water, filtering and collecting the filtrate.

4. The preparation method according to claim 3, characterized in that: The decoction time is 20 to 60 minutes.

5. Use of the Chinese medicine composition according to any one of claims 1 to 2 in the preparation of a medicament for preventing and / or treating pulmonary infectious diseases.

6. The use according to claim 5, characterized in that: The pulmonary infectious diseases include pneumonia, lung cysts or pulmonary tuberculosis.

7. The use according to claim 6, characterized in that: The pneumonia includes viral pneumonia, bacterial pneumonia, fungal pneumonia or mycoplasma pneumonia.

8. The use according to claim 7, characterized in that: The viruses in the viral pneumonia include the new coronavirus, influenza virus, coxsackie virus or adenovirus.

9. A drug for preventing and / or treating pulmonary infectious diseases, characterized in that: The medicine comprises the Chinese medicine composition according to any one of claims 1 to 2 and pharmaceutically acceptable excipients.

10. The drug according to claim 9, characterized in that The drug dosage forms include decoctions, pills, powders, pastes, granules, oral liquids, capsules or tablets.

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