Traditional Chinese medicine composition for resisting inflammation and removing stasis and preparation method thereof

Abstract

The invention discloses an anti-inflammatory and stasis-removing traditional Chinese medicine composition and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines, the anti-inflammatory and stasis-removing traditional Chinese medicine composition comprises the following raw materials: exocarpium citri grandis, honeysuckle, poria cocos, coix seeds, houttuynia cordata, radix rehmanniae, white hyacinth beans, fingered citron, bitter apricot kernels, oysters, bighead atractylodes rhizome, polygonatum kingianum, radix angelicae, dandelion, kelp, turtle shells, donkey-hide gelatin, pulp of dogwood fruit, Chinese yam, codonopsis pilosula, adenophora stricta and xylitol. The traditional Chinese medicine composition has the beneficial effects that the formula composition is reasonable, toxic medicinal materials are not contained, incompatibility is avoided, and good anti-inflammatory and stasis-removing effects are achieved. After the compatibility of monarch drugs of exocarpium citri grandis and honeysuckle in parts by weight is adjusted, the expression of TNF-alpha and iL-6 in LPS-induced inflammatory reaction can be synergistically inhibited. The raw materials are all natural soothing components, the medicine effect is mild, safe and reasonable, the process is simple, the clinical effect is reliable, no obvious toxic or side effect or adverse reaction occurs in the application process, the clinical effect is ensured, and the quality is controllable.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and in particular to an anti-inflammatory and knot-dispersing traditional Chinese medicine composition and a preparation method thereof. Background Art

[0002] The meridian theory in traditional Chinese medicine believes that there is a meridian system in the human body. When inflammation occurs, the meridians are blocked, resulting in poor blood circulation in the inflamed area and stagnation of qi and blood. The anti-inflammatory and nodule-dispersing treatment concept of traditional Chinese medicine is mainly to regulate the meridians, promote the circulation of qi and blood, and improve local conditions, thereby accelerating the disappearance of inflammation and the disappearance of nodules. In addition, according to clinical experience, the problem of qi and blood circulation is mostly attributed to the weakness of the internal organs. The prescriptions are mostly selected by using traditional classic prescriptions such as Codonopsis pilosula, Atractylodes macrocephala, and Poria cocos, which play the role of strengthening the spleen and replenishing qi, strengthening the body and expelling evil, and combining circulation with supplementation. In the theoretical system of traditional Chinese medicine, the diseases related to anti-inflammatory and nodule-dispersing are extensive and diverse, and the main systems and diseases involved include respiratory system diseases such as acute pharyngitis, acute tonsillitis, etc., digestive system diseases such as cholangitis, dysentery, etc., and motor system diseases such as joint swelling and pain, rheumatoid arthritis, etc.

[0003] At present, the main principles for the treatment of the above-mentioned diseases related to anti-inflammatory and dispersing diseases are to remove dampness and resolve phlegm, clear away heat and detoxify, etc., and to adjust from multiple directions by combining a variety of mild ingredients, such as using drugs containing plant hormones, steroids or analogs to regulate the body's stress state, partially blocking the production of inflammatory mediator molecules arachidonic acid derivatives; using drugs containing cyclooxygenase and lipoxygenase inhibitors to appropriately block the production of inflammatory mediator molecules; using drugs rich in flavonoids and phenolic components to fight oxygen free radicals and regulate the oxidation-antioxidation state in the cell environment; using drugs that enhance immune function to promote the destruction and phagocytosis of inflammatory tissues; using drugs that promote blood circulation, diuresis and laxatives to promote the transfer and excretion of destroyed inflammatory tissues and metabolic wastes. Traditional Chinese medicine has always had the concept of slow treatment of chronic diseases, that is, for chronic diseases, the main focus is on cultivating the body's positive energy and allowing the body to gradually recover; rather than advocating the use of large doses of drugs to attack in order to quickly relieve the condition. These concepts are exactly in line with the concept of regulating the internal environment of cell biology and cultivating the body's own regulatory function. Long-term reuse and single use of one or two ingredients of a drug will actually lead to new environmental imbalances, which is actually not conducive to the treatment of chronic diseases. Clinically, Western medicine does not have a corresponding disease. When people have the above symptoms, they often go to the gastroenterology department and the stomatology department. The treatment method is mainly symptomatic treatment, giving gastrointestinal motility-promoting drugs, Chinese patent medicines for clearing away heat and detoxification, etc. The effect is not certain and it is difficult to cure.

[0004] In view of this, the inventor conducted in-depth research on this demand, and thus the present case was produced. Summary of the invention

[0005] To solve the above problems, the present invention provides an anti-inflammatory and nodule-dispersing Chinese medicine composition and a preparation method thereof, which has the effects of anti-inflammatory and nodule-dispersing, so as to achieve the purpose of treating diseases related to anti-inflammatory and nodule-dispersing and improve the clinical treatment effect of related diseases.

[0006] The invention provides an anti-inflammatory and knot-dispersing Chinese medicine composition, which comprises the following raw materials: tangerine peel, honeysuckle, tuckahoe, coix seed, houttuynia cordata, radix rehmanniae, white hyacinth bean, bergamot, bitter almond, oyster, atractylodes macrocephala, polygonatum sibiricum, angelica dahurica, dandelion, kelp, turtle shell, donkey-hide gelatin, cornus fruit, yam, codonopsis pilosula, adenophora radix and xylitol.

[0007] Preferably, the following raw materials are included by weight: 150-350 parts of Huajuhong, 150-350 parts of honeysuckle, 100-300 parts of Poria, 100-300 parts of Coix seeds, 100-300 parts of Houttuynia cordata, 30-120 parts of Radix Rehmanniae, 30-120 parts of White Lablab, 30-120 parts of Citron, 30-120 parts of Bitter Apricot, 30-120 parts of Oyster, 30-120 parts of Atractylodes macrocephala, 30-120 parts of Polygonatum, 30-120 parts of Angelica dahurica, 20-80 parts of Taraxacum, 20-80 parts of Kelp, 20-80 parts of Turtle Shell, 5-60 parts of Donkey-hide Gelatin, 5-60 parts of Cornus officinalis, 5-60 parts of Chinese Yam, 5-30 parts of Codonopsis pilosula, 5-30 parts of Adenophora adenophora, and 5-30 parts of xylitol.

[0008] Preferably, the following raw materials are included by weight: 200-300 parts of Huajuhong, 200-300 parts of honeysuckle, 150-250 parts of Poria, 150-250 parts of Coix seeds, 150-250 parts of Houttuynia cordata, 50-100 parts of Radix Rehmanniae, 50-100 parts of White Lablab, 50-100 parts of Citron, 50-100 parts of Bitter Apricot, 50-100 parts of Oyster, 50-100 parts of Atractylodes macrocephala, 50-100 parts of Polygonatum sibiricum, 50-100 parts of Angelica dahurica, 30-70 parts of Taraxacum, 30-70 parts of Kelp, 30-70 parts of Turtle Shell, 10-50 parts of Donkey-hide Gelatin, 10-50 parts of Cornus officinalis, 10-50 parts of Chinese Yam, 10-20 parts of Codonopsis pilosula, 10-20 parts of Adenophora adenophora, and 10-20 parts of xylitol.

[0009] Preferably, the following raw materials are included by weight: 200-250 parts of Huajuhong, 250-300 parts of honeysuckle, 180-220 parts of Poria, 180-220 parts of Coix seeds, 180-220 parts of Houttuynia cordata, 50-80 parts of Radix Rehmanniae, 50-80 parts of White Lablab, 50-80 parts of Citron, 50-80 parts of Bitter Apricot, 50-80 parts of Oyster, 50-80 parts of Atractylodes macrocephala, 50-80 parts of Polygonatum sibiricum, 50-80 parts of Angelica dahurica, 30-60 parts of Taraxacum, 30-60 parts of Kelp, 30-60 parts of Turtle Shell, 10-30 parts of Donkey-hide Gelatin, 10-30 parts of Cornus officinalis, 10-30 parts of Chinese Yam, 10-15 parts of Codonopsis pilosula, 10-15 parts of Adenophora adenophora, and 10-15 parts of xylitol.

[0010] The present invention also provides the use of the anti-inflammatory and knot-dispersing Chinese medicine composition in the preparation of anti-inflammatory and knot-dispersing medicines.

[0011] The present invention also provides an anti-inflammatory and mass-dispersing medicine, comprising the anti-inflammatory and mass-dispersing traditional Chinese medicine composition and pharmaceutically acceptable adjuvants.

[0012] Preferably, the dosage form of the above-mentioned medicine is Chinese medicine decoction, decoction, granules, pills, capsules, tablets, tea, suspension, powder or oral solution.

[0013] Preferably, the present invention also provides a method for preparing the above-mentioned medicine, wherein the medicine is a pill, and the preparation method thereof is as follows:

[0014] Step 1, weighing the raw materials according to the weight ratio, cleaning, drying, cutting, crushing, sieving, and mixing evenly;

[0015] Step 2: Soak the raw materials in clean water for 0.5 to 1 hour, heat to 80-100°C, and boil repeatedly for 1 to 3 times, with the weight of water added each time being 10 to 20 times the total weight of all raw materials, and the heating and boiling time is 1.5 to 2 hours, and finally the filtrate is combined;

[0016] Step 3, after the filtrate is allowed to settle, the supernatant is taken out, concentrated into a clear paste composition, spray-dried to obtain a clear paste powder, added with refined honey, and made into pills according to conventional processes.

[0017] The beneficial effects produced by the technical solution of the present invention are as follows:

[0018] In the Chinese medicine composition of the present invention, Huajuhong and Jinyinhua are the main drugs, Huajuhong dispels dampness and resolves phlegm, relieves the middle and disperses the knots, Jinyinhua clears away heat and detoxifies, and is anti-inflammatory; Poria, Coix seeds, and Houttuynia cordata are the assistant drugs, Poria and Coix seeds can promote diuresis and eliminate dampness, resist inflammation and antioxidant, and Houttuynia cordata clears away heat and detoxifies, and is anti-inflammatory and disperses the knots; Radix Rehmanniae, White Lablab, Citron, Bitter Apricot Kernel, Oyster, Atractylodes macrocephala, Polygonatum sibiricum, and Angelica dahurica are the adjuvant drugs, Citron can soothe the liver, regulate qi and harmonize the stomach, dry dampness and resolve phlegm, Radix Rehmanniae clears heat and cools blood, nourishes yin and promotes fluid production, White Lablab Bean strengthens the spleen and resolves dampness, harmonizes the middle and relieves heat, Bitter Apricot Kernel relieves cough and asthma, moistens the intestines and relieves constipation, Oyster stops sweating and astringes sperm, resolves phlegm and softens hard masses, Atractylodes macrocephala strengthens the spleen and replenishes qi, Drying dampness and promoting diuresis, Polygonatum sibiricum replenishes Qi and nourishes Yin, strengthens the spleen and moistens the lungs, Angelica dahurica relieves exterior symptoms and dispels cold, dispels wind and relieves pain; Dandelion, kelp, turtle shell, donkey-hide gelatin, Cornus officinalis, Chinese yam, Codonopsis pilosula, and Adenophora stellaria are all used as guiding herbs. Dandelion is a diuretic and resolves nodules, clears away heat and detoxifies, kelp promotes blood circulation and resolves nodules, softens and resolves phlegm, turtle shell nourishes yin and suppresses yang, reduces fever and eliminates steam, softens and resolves nodules, donkey-hide gelatin replenishes blood and stops bleeding, nourishes yin and moistens dryness, Cornus officinalis nourishes the liver and kidneys, is astringent and firm, Chinese yam replenishes the spleen and nourishes the stomach, has anti-inflammatory and pain relief, Codonopsis pilosula strengthens the spleen and benefits the lungs, nourishes blood and produces body fluid, Adenophora stellaria nourishes yin and clears the lungs, benefits the stomach and produces body fluid; Xylitol is a synthetic food sweetener and multifunctional food additive with a sweet taste and is used as an auxiliary medicine.

[0019] The prescription composition of the present invention is reasonable, does not contain toxic medicinal materials, has no incompatibility, and has a good anti-inflammatory and dispersing effect. After adjusting the weight ratio of the main medicine Huajuhong and honeysuckle, the expression of TNF-α and iL-6 in the inflammatory response induced by LPS can be synergistically inhibited. In addition, the raw materials are all natural soothing ingredients, the efficacy is mild, safe and reasonable, the process is simple, the clinical efficacy is reliable, no obvious toxic side effects and adverse reactions occur during the application process, the clinical efficacy is ensured, and the quality is controllable. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings required for use in the embodiments will be briefly introduced below. It should be understood that the following drawings only show certain embodiments of the present invention and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other related drawings can be obtained based on these drawings without paying creative work.

[0021] Figure 1 This is a graph of cell survival rates in Experiment 2 of the embodiment of the present invention. DETAILED DESCRIPTION

[0022] In order to make the purpose, technical scheme and advantages of the embodiments of the present invention clearer, the technical scheme in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are part of the embodiments of the present invention, rather than all the embodiments. Therefore, the following detailed description of the embodiments provided by the present invention is not intended to limit the scope of the claimed invention, but merely represents the selected embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0023] The present invention provides an anti-inflammatory and stagnation-dispersing Chinese medicine composition and a preparation method thereof, which has the effect of anti-inflammatory and stagnation-dispersing, so as to achieve the purpose of treating diseases related to anti-inflammatory and stagnation-dispersing and improve the clinical treatment effect of related diseases. The specific implementation method is as follows:

[0024] The invention provides an anti-inflammatory and knot-dispersing Chinese medicine composition, which comprises the following raw materials: tangerine peel, honeysuckle, tuckahoe, coix seed, houttuynia cordata, radix rehmanniae, white hyacinth bean, bergamot, bitter almond, oyster, atractylodes macrocephala, polygonatum sibiricum, angelica dahurica, dandelion, kelp, turtle shell, donkey-hide gelatin, cornus fruit, yam, codonopsis pilosula, adenophora radix and xylitol.

[0025] As a preferred embodiment, the invention comprises the following raw materials in parts by weight: 150-350 parts of Huajuhong, 150-350 parts of honeysuckle, 100-300 parts of Poria, 100-300 parts of Coix seeds, 100-300 parts of Houttuynia cordata, 30-120 parts of Radix Rehmanniae, 30-120 parts of White Lablab, 30-120 parts of Citron, 30-120 parts of Bitter Apricot, 30-120 parts of Oyster, 30-120 parts of Atractylodes macrocephala, 30-120 parts of Polygonatum sibiricum, 30-120 parts of Angelica dahurica, 20-80 parts of Taraxacum, 20-80 parts of Kelp, 20-80 parts of Turtle Shell, 5-60 parts of Donkey-hide Gelatin, 5-60 parts of Cornus officinalis, 5-60 parts of Chinese Yam, 5-30 parts of Codonopsis pilosula, 5-30 parts of Adenophora adenophora, and 5-30 parts of xylitol.

[0026] As a preferred embodiment, the invention comprises the following raw materials in parts by weight: 200-300 parts of Huajuhong, 200-300 parts of honeysuckle, 150-250 parts of Poria, 150-250 parts of Coix seeds, 150-250 parts of Houttuynia cordata, 50-100 parts of Radix Rehmanniae, 50-100 parts of White Lablab, 50-100 parts of Citron, 50-100 parts of Bitter Apricot, 50-100 parts of Oyster, 50-100 parts of Atractylodes macrocephala, 50-100 parts of Polygonatum sibiricum, 50-100 parts of Angelica dahurica, 30-70 parts of Taraxacum, 30-70 parts of Kelp, 30-70 parts of Turtle Shell, 10-50 parts of Donkey-hide Gelatin, 10-50 parts of Cornus officinalis, 10-50 parts of Chinese Yam, 10-20 parts of Codonopsis pilosula, 10-20 parts of Adenophora adenophora, and 10-20 parts of xylitol.

[0027] As a preferred embodiment, the invention comprises the following raw materials in parts by weight: 200-250 parts of Huajuhong, 250-300 parts of honeysuckle, 180-220 parts of Poria, 180-220 parts of Coix seeds, 180-220 parts of Houttuynia cordata, 50-80 parts of Radix Rehmanniae, 50-80 parts of White Lablab, 50-80 parts of Citron, 50-80 parts of Bitter Apricot, 50-80 parts of Oyster, 50-80 parts of Atractylodes macrocephala, 50-80 parts of Polygonatum sibiricum, 50-80 parts of Angelica dahurica, 30-60 parts of Taraxacum, 30-60 parts of Kelp, 30-60 parts of Turtle Shell, 10-30 parts of Donkey-hide Gelatin, 10-30 parts of Cornus officinalis, 10-30 parts of Chinese Yam, 10-15 parts of Codonopsis pilosula, 10-15 parts of Adenophora adenophora, and 10-15 parts of xylitol.

[0028] The present invention also provides the use of the anti-inflammatory and knot-dispersing Chinese medicine composition in the preparation of anti-inflammatory and knot-dispersing medicines.

[0029] The present invention also provides an anti-inflammatory and mass-dispersing medicine, comprising the anti-inflammatory and mass-dispersing traditional Chinese medicine composition and pharmaceutically acceptable adjuvants.

[0030] As a preferred embodiment, the dosage form of the above-mentioned medicine is Chinese medicine decoction, decoction, granules, pills, capsules, tablets, tea, suspension, powder or oral solution.

[0031] As a preferred embodiment, the present invention also provides a method for preparing the above-mentioned medicine, wherein the medicine is a pill, and the preparation method thereof is as follows:

[0032] Step 1, weighing the raw materials according to the weight ratio, cleaning, drying, cutting, crushing, sieving, and mixing evenly;

[0033] Step 2: Soak the raw materials in clean water for 0.5 to 1 hour, heat to 80-100°C, and boil repeatedly for 1 to 3 times, with the weight of water added each time being 10 to 20 times the total weight of all raw materials, and the heating and boiling time is 1.5 to 2 hours, and finally the filtrate is combined;

[0034] Step 3, after the filtrate is allowed to settle, the supernatant is taken out, concentrated into a clear paste composition, spray-dried to obtain a clear paste powder, added with refined honey, and made into pills according to conventional processes.

[0035] The present invention is further described in detail below in conjunction with specific embodiments:

[0036] Example 1

[0037] An anti-inflammatory and knot-dispersing medicine, the raw materials of which include: 200 parts of Huajuhong, 200 parts of honeysuckle, 150 parts of Poria, 150 parts of Coix seeds, 150 parts of Houttuynia cordata, 50 parts of Radix Rehmanniae, 50 parts of White Lablab, 50 parts of Citron, 50 parts of Bitter Apricot, 50 parts of Oyster, 50 parts of Atractylodes macrocephala, 50 parts of Polygonatum sibiricum, 50 parts of Angelica dahurica, 30 parts of Taraxacum mongolicum, 30 parts of Kelp, 30 parts of Carapace of Turtle, 10 parts of Ejiao, 10 parts of Cornus officinalis, 10 parts of Chinese Yam, 10 parts of Codonopsis pilosula, 10 parts of Adenophora adenophora, and 10 parts of xylitol. The preparation method of the pills is as follows:

[0038] Step 1, weighing the raw materials according to the weight ratio, cleaning, drying, cutting, crushing, sieving, and mixing evenly;

[0039] Step 2: Soak the raw materials in clean water for 0.5 to 1 hour, heat to 80-100°C, and boil repeatedly for 1 to 3 times, with the weight of water added each time being 10 to 20 times the total weight of all raw materials, and the heating and boiling time is 1.5 to 2 hours, and finally the filtrate is combined;

[0040] Step 3, after the filtrate is allowed to settle, the supernatant is taken out, concentrated into a clear paste composition, spray-dried to obtain a clear paste powder, added with refined honey, and made into pills according to conventional processes.

[0041] Example 2

[0042] An anti-inflammatory and knot-dispersing medicine, wherein the raw materials include: 200 parts of Huajuhong, 250 parts of honeysuckle, 180 parts of Poria, 180 parts of Coix seeds, 180 parts of Houttuynia cordata, 50 parts of Radix Rehmanniae, 50 parts of Lablab dahliae, 50 parts of Citron, 50 parts of Bitter Apricot, 50 parts of Oyster, 50 parts of Atractylodes macrocephala, 50 parts of Polygonatum sibiricum, 50 parts of Angelica dahurica, 30 parts of Taraxacum mongolicum, 30 parts of Kelp, 30 parts of Carapace of Turtle, 10 parts of Ejiao, 10 parts of Cornus officinalis, 10 parts of Dioscorea opposita, 10 parts of Codonopsis pilosula, 10 parts of Adenophora adenophora, and 10 parts of xylitol. The preparation method of the pill is the same as that of Example 1.

[0043] Example 3

[0044] An anti-inflammatory and knot-dispersing medicine, wherein the raw materials include: 250 parts of Huajuhong, 300 parts of honeysuckle, 220 parts of Poria, 220 parts of Coix seeds, 220 parts of Houttuynia cordata, 80 parts of Radix Rehmanniae, 80 parts of Lablab dahliae, 80 parts of Citron, 80 parts of Bitter Apricot, 80 parts of Oyster, 80 parts of Atractylodes macrocephala, 80 parts of Polygonatum, 80 parts of Angelica dahurica, 60 parts of Taraxacum, 60 parts of Kelp, 60 parts of Carapace of Turtle, 30 parts of Ejiao, 30 parts of Cornus officinalis, 30 parts of Chinese Yam, 15 parts of Codonopsis pilosula, 15 parts of Adenophora adenophora, and 15 parts of xylitol. The preparation method of the pill is the same as that of Example 1.

[0045] Example 4

[0046] An anti-inflammatory and stagnation-dispersing medicine, wherein the raw materials include: 150 parts of Huajuhong, 150 parts of honeysuckle, 100 parts of Poria, 100 parts of Coix seeds, 100 parts of Houttuynia cordata, 30 parts of Radix Rehmanniae, 30 parts of White Lablab, 30 parts of Citron, 30 parts of Bitter Apricot, 30 parts of Oyster, 30 parts of Atractylodes macrocephala, 30 parts of Polygonatum, 30 parts of Angelica dahurica, 20 parts of Taraxacum, 20 parts of Kelp, 20 parts of Carapace of Turtle, 5 parts of Ejiao, 5 parts of Cornus officinalis, 5 parts of Chinese Yam, 5 parts of Codonopsis pilosula, 5 parts of Adenophora adenophora, and 5 parts of xylitol. The preparation method of the pill is the same as that of Example 1.

[0047] Example 5

[0048] An anti-inflammatory and knot-dispersing medicine, wherein the raw materials include: 300 parts of Huajuhong, 300 parts of honeysuckle, 250 parts of Poria, 250 parts of Coix seeds, 250 parts of Houttuynia cordata, 100 parts of Radix Rehmanniae, 100 parts of Lablab dahliae, 100 parts of Citronella, 100 parts of Manchurian citron, 100 parts of Apricot kernel, 100 parts of Oyster, 100 parts of Atractylodes macrocephala, 100 parts of Polygonatum sibiricum, 100 parts of Angelica dahurica, 70 parts of Taraxacum mongolicum, 70 parts of Laminaria japonica, 70 parts of Carapace of Turtle, 50 parts of Ejiao, 50 parts of Cornus officinalis, 50 parts of Chinese Yam, 20 parts of Codonopsis pilosula, 20 parts of Adenophora adenophora, and 20 parts of xylitol. The preparation method of the pill is the same as that of Example 1.

[0049] Example 6

[0050] An anti-inflammatory and stagnation-dispersing medicine, wherein the raw materials include: 350 parts of Huajuhong, 350 parts of honeysuckle, 300 parts of Poria, 300 parts of Coix seeds, 300 parts of Houttuynia cordata, 120 parts of Radix Rehmanniae, 120 parts of Lablab dahliae, 120 parts of Citronella, 120 parts of Bitter Apricot, 120 parts of Oyster, 120 parts of Atractylodes macrocephala, 120 parts of Polygonatum, 120 parts of Angelica dahurica, 80 parts of Taraxacum, 80 parts of Kelp, 80 parts of Carapace of Turtle, 60 parts of Ejiao, 60 parts of Cornus officinalis, 60 parts of Chinese Yam, 30 parts of Codonopsis pilosula, 30 parts of Adenophora adenophora, and 30 parts of xylitol. The preparation method of the pill is the same as that of Example 1.

[0051] Comparative Example 1

[0052] An anti-inflammatory and stagnation-dispersing medicine, wherein the raw materials include: 200 parts of Huajuhong, 180 parts of Poria, 180 parts of Coix seeds, 180 parts of Houttuynia cordata, 50 parts of Radix Rehmanniae, 50 parts of Lablab dahliae, 50 parts of Citronella, 50 parts of Bitter Apricot, 50 parts of Oyster, 50 parts of Atractylodes macrocephala, 50 parts of Polygonatum sibiricum, 50 parts of Angelica dahurica, 30 parts of Taraxacum mongolicum, 30 parts of Kelp, 30 parts of Carapace of Turtle, 10 parts of Ejiao, 10 parts of Cornus officinalis, 10 parts of Dioscorea opposita, 10 parts of Codonopsis pilosula, 10 parts of Adenophora adenophora, and 10 parts of xylitol. The preparation method of the pill is the same as that of Example 2.

[0053] Comparative Example 2

[0054] An anti-inflammatory and knot-dispersing medicine, wherein the raw materials include: 250 parts of honeysuckle, 180 parts of tuckahoe, 180 parts of coix seeds, 180 parts of houttuynia, 50 parts of radix rehmanniae, 50 parts of labiatae, 50 parts of bergamot, 50 parts of bitter almonds, 50 parts of oysters, 50 parts of atractylodes macrocephala, 50 parts of polygonatum, 50 parts of angelica dahurica, 30 parts of dandelions, 30 parts of kelp, 30 parts of turtle shell, 10 parts of donkey-hide gelatin, 10 parts of cornus fruit, 10 parts of yam, 10 parts of codonopsis pilosula, 10 parts of adenophora, and 10 parts of xylitol. The preparation method of the pills is the same as that of Example 2.

[0055] Experiment 1: The drugs prepared in the preferred embodiments 1 to 3 and comparative examples 1 to 2 were used to conduct experiments to identify the effects of the drugs provided by the present invention on removing dampness and dispersing stagnation:

[0056] (1) Experimental animals

[0057] Thirty-six healthy SPF male mice, aged 7 to 8 weeks and weighing 120 to 125 g, were purchased from the Experimental Animal Center of Guangzhou University of Chinese Medicine and raised in the SPF Animal Experimental Center of the First Affiliated Hospital of Guangzhou University of Chinese Medicine. The experimental environment was a constant temperature of 20 to 25°C, a relative humidity of 40 to 60%, a light cycle of 12 hours, and free access to food and water. The experiment began after one week of adaptive feeding.

[0058] (2) Experimental drugs

[0059] The experimental raw materials were purchased from the First Affiliated Hospital of Guangzhou University of Chinese Medicine. After being identified by the Chinese Medicine Identification Teaching and Research Office of Guangzhou University of Chinese Medicine, the purchased medicinal materials all met the standards of the Pharmacopoeia of the People's Republic of China, and the excipients used met the standards for the use of food additives in the Pharmacopoeia of the People's Republic of China or GB 2760.

[0060] (3) Modeling and experimental grouping

[0061] After 1 week of adaptive feeding, 36 mice were randomly divided into 6 groups:

[0062] ①Modeling group,

[0063] ② Example 1 medication group,

[0064] ③ Example 2 medication group,

[0065] ④ Example 3 medication group,

[0066] ⑤Comparative Example 1 medication group,

[0067] ⑥Comparative Example 2 medication group;

[0068] 36 mice were placed in a sealed box at a temperature of 25-35°C and a humidity of 70%-80%, and continuously fed with high-fat feed for 12 days. A moisture obesity model was constructed by high-fat diet and high humidity environment, and 6 mice were randomly selected as the modeling group. The remaining mice were randomly divided into 5 groups, namely, the Example 1 administration group, the Example 2 administration group, the Example 3 administration group, the Comparative Example 1 administration group and the Comparative Example 2 administration group. On the basis of modeling, each group was gavaged with 10g of the pills prepared by Examples 1-3 and Comparative Examples 1-2, divided into two administrations a day, morning and evening, for 14 consecutive days, and the weight difference of each group of mice before and after the experiment was recorded. The modeling group adopted a normal diet for 14 days. The weight changes are shown in Table 1.

[0069] (3) Experimental results

[0070] Table 1 Effects of each group of pills on rat body weight

[0071]

[0072] (P<0.05 indicates a significant difference ( * ), P<0.01 indicates a very significant difference ( ** ))

[0073] As can be seen from the results in Table 1, for mice suffering from dampness-induced obesity, the weight change is not significant only through a normal diet, but the weight of the mice taking the pills prepared by Examples 1 to 3 is significantly reduced compared with the mice taking the pills prepared by Comparative Examples 1 to 2, indicating that it has the effect of reducing weight and removing dampness and dispersing stagnation.

[0074] Experiment 2: The drugs prepared in the preferred embodiments 1 to 3 and comparative examples 1 to 2 were used to conduct experiments to identify the anti-inflammatory effects of the drugs provided by the present invention:

[0075] (1) Drug preparation

[0076] 20 g of the pills prepared in Examples 1 to 3 and Comparative Examples 1 to 2 were weighed, ground, and added to 10 mL of water to fully dissolve to prepare corresponding 2 g / mL drug solutions.

[0077] (2) Model building

[0078] RAW264.7 cells were seeded in 96-well plates at 1×10 6 cells per well and cultured overnight at 37°C.

[0079] (3) Formal Experiment

[0080] The cells were treated with 2 g / mL of the drug solutions obtained in Examples 1 to 3 and Comparative Examples 1 to 2 for 24 h, the culture medium was discarded, an appropriate amount of MTT working solution was added, and the cells were placed in a cell culture incubator for further incubation for 2 h, and then an appropriate amount of stop solution was added. After incubation for 2 h, the OD value was measured at 562 nm using an ELISA instrument to calculate the cell survival rate. Figure 1 .

[0081] (4) Experimental results

[0082] Depend on Figure 1 The results show that the 2 g / mL drug solutions prepared by the pills of Examples 1 to 3 and Comparative Examples 1 to 2 have good biocompatibility, and the cell survival rates are all above 99.5%, and the cell survival rates of Examples 1 to 3 are higher than those of Comparative Examples 1 to 2. It can be seen that all the above pills are highly safe and non-toxic, and Examples 1 to 3 are safer.

[0083] Experiment 3: The drugs prepared in the preferred embodiments 1 to 3 and comparative examples 1 to 2 were used to conduct experiments to identify the anti-inflammatory effect of the drugs provided by the present invention on LPS-induced RAW264.7 inflammatory cells:

[0084] (1) Drug preparation

[0085] 20 g of the pills prepared in Examples 1 to 3 and Comparative Examples 1 to 2 were weighed, ground, and added to 10 mL of water to fully dissolve to prepare corresponding 2 g / mL drug solutions.

[0086] (2) Model building

[0087] The inflammation model was constructed by stimulating mouse mononuclear macrophage RAW264.7 cells with bacterial lipopolysaccharide (LPS) using conventional techniques.

[0088] (3) Formal Experiment

[0089] RAW264.7 cells were seeded in 96-well plates at 2×106 cells per well and cultured overnight. After the cells adhered to the wall, 2 g / mL of drug solution in each group was added to the model cells, and an equal amount of culture medium was added as the control group. After culturing together for 24 hours, the corresponding concentrations were measured using commercially available kits that can detect TNF-α and iL-6 inflammatory factors before and after the experiment. The concentration changes are shown in Table 2.

[0090] Table 2 Effects of each group of pills on RAW264.7 cells

[0091]

[0092] (P<0.05 indicates a significant difference (*), P<0.01 indicates an extremely significant difference (**))

[0093] As shown in Table 2, for LPS-induced RAW264.7 inflammatory cells, Comparative Example 1 of taking the pill solution prepared with Huajuhong as the main drug and Comparative Example 2 of taking the pill solution prepared with Jin Yinhua as the main drug both have the effect of reducing TNF-α and iL-6 inflammatory factors in inflammatory cells, which has significant statistical significance. However, the pill solution prepared in Examples 1 to 3 has a more significant anti-inflammatory effect, and the Jin's formula is used to evaluate the effect of the combined medication of Huajuhong and Jin Yinhua. The conventional Jin's formula stipulates that Q<0.85 has an antagonistic effect, 0.85≤Q≤1.15 has an additive effect, and Q>1.15 has a synergistic effect.

[0094] By calculating the Q value of the pill preparation solution of Example 2, it can be seen that the Q for TNF-α is 1.456; the Q for iL-6 inflammatory factor is 1.712, and the Q is greater than the Q>1.15 specified by the King's formula. It can be seen that the pill preparation solution of Example 3 has a synergistic effect on inhibiting LPS stimulation and promoting the release of inflammatory factors in RAW264.7 cells.

[0095] Typical cases:

[0096] Case 1:

[0097] Patient He, male, 55 years old, had lung nodules for more than 1 year. He came to the hospital for treatment in August 2023. Chest CT examination showed a left upper lung nodule, about 0.6×0.8cm in size. The clinical manifestations were repeated coughing with white sputum, occasional shortness of breath and chest tightness, sticky and uncomfortable stools, often rotten, clear and long urine, general appetite and sleep, pale red tongue, white and greasy fur, and slippery pulse. Chinese medicine diagnosis: accumulation of disease, spleen deficiency and phlegm syndrome; Western medicine diagnosis: lung nodules; oral administration of the Chinese medicine compound extract paste prescription preparation containing Example 2 provided by the present invention, twice a day, 10-15g each time, taken after meals, 28 days for 1 course of treatment, and 3 courses of treatment in succession. After taking 1 course of treatment, cough and sputum were significantly relieved, there was no complaint of shortness of breath and chest tightness, the stool gradually formed, the tongue was pale red, the fur was thin and white, and the pulse was slippery. In November 2023, our hospital reviewed the chest CT and showed a 0.5×0.6cm nodule in the left upper lung, and no new lesions were found. The results showed that this prescription can effectively relieve chest symptoms such as cough and sputum in patients with lung nodules, and can also reduce the size of lung nodule lesions. It has a good clinical effect on patients with spleen deficiency and phlegm-dampness type sarcoidosis.

[0098] Case 2:

[0099] Patient Luo, female, 76 years old, had thyroid nodules for more than 10 years and underwent thyroid tumor removal twice in foreign hospitals. In March 2024, she came to the hospital for treatment. The thyroid B-ultrasound examination showed that the thyroid was enlarged, with multiple nodules, and the largest lesion was about 2.6×3.2cm. The clinical manifestations were swelling of the neck, repeated throat discomfort, chest fullness, uncomfortable sputum, rotten stool, general appetite, dark red tongue, thick white fur, and slippery pulse. Chinese medicine diagnosis: accumulation of disease, spleen deficiency and phlegm and blood stasis syndrome; Western medicine diagnosis: nodular goiter; oral administration of the Chinese medicine compound extract paste preparation containing Example 2 provided by the present invention, twice a day, 10 to 15g each time, taken after meals, 28 days for 1 course of treatment, and 3 courses of treatment in succession. After taking 1 course of treatment, the throat discomfort was relieved, the chest tightness was significantly improved, and the stool was gradually formed after taking 3 courses of treatment. The tongue was light red, the fur was thin and greasy, and the pulse was thin and smooth. In July 2024, the neck swelling was significantly improved, and the hospital's reexamination of B-ultrasound showed that the largest lesion was 2.2×2.8cm. The results showed that this prescription can effectively relieve the throat and chest discomfort symptoms of patients with nodular goiter (thyroid nodules), and at the same time can significantly reduce the thyroid lesions, and has a good clinical effect on patients with spleen deficiency and phlegm stasis type sarcoidosis.

[0100] Case 3:

[0101] Patient Ma, female, 47 years old, more than 5 months after breast cancer surgery. The patient underwent breast surgery in an external hospital in December 2023. Postoperative pathology indicated invasive adenocarcinoma, and standardized radiotherapy, chemotherapy and endocrine treatment were performed after surgery. The review in March 2024 indicated a right breast nodule, about 0.8×0.9cm in size, BI-RADS4A category, and no obvious special discomfort except mental anxiety during the consultation. The tongue is dark red, the tongue coating is white and greasy, and the pulse is stringy and slippery. Chinese medicine diagnosis: accumulation of disease, spleen deficiency and phlegm and blood stasis syndrome; Western medicine diagnosis: breast malignancy, breast fibroids; oral administration of the Chinese medicine compound extract paste preparation containing Example 2 provided by the present invention, twice a day, 10 to 15g each time, taken after meals, 28 days for 1 course of treatment, and 3 courses of treatment in succession. After taking 3 courses of treatment, the patient had no special circumstances, the tongue was pale red, the tongue coating was thin and greasy, and the pulse was thin. In August 2024, the B-ultrasound examination at another hospital showed a right breast nodule, about 0.7×0.8cm in size, BI-RADS3, and no abnormality in the original breast cancer surgery site. The results showed that this prescription can effectively treat breast fibroids (breast nodules) lesions, shrink and downgrade the original lesions, and has a good clinical effect on patients with spleen deficiency and phlegm stasis type sarcoidosis.

[0102] Case 4:

[0103] Patient Wu, male, 60 years old, had intrahepatic cysts for more than 1 year. He came to the hospital for treatment in August 2023. The liver B-ultrasound and upper abdominal CT showed liver S6 lesions, about 1.6×1.9cm in size, and cysts were considered. The clinical manifestations were pain in the right ribs, occasional nausea and pantothenic acid, loose stools, poor appetite and sleep, dark red tongue, thin white greasy fur, and stringy and slippery pulse. Chinese medicine diagnosis: accumulated disease, liver depression and spleen deficiency syndrome; Western medicine diagnosis: liver cysts; oral administration of the Chinese medicine compound extract paste prescription preparation containing Example 2 provided by the present invention, twice a day, 10-15g each time, taken after meals, 28 days for 1 course of treatment, and 3 courses of treatment in succession. After taking 1 course of treatment, there was no complaint of pain in the ribs. After taking 3 courses of treatment, the stool gradually took shape, the tongue was light red, the fur was thin and white, and the pulse was thin. In November 2023, the hospital re-examined the B-ultrasound and indicated that the intrahepatic cyst was 1.2×1.4cm, and no new lesions were found. The results showed that this prescription can effectively relieve chest symptoms such as pain in patients with liver space-occupying lesions, and can also reduce the size of liver cyst lesions. It has a good clinical effect on patients with liver cysts of liver depression and spleen deficiency type.

[0104] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. For those skilled in the art, the present invention may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. An anti-inflammatory and stagnation-dispersing Chinese medicine composition, characterized in that: The ingredients include: dried tangerine peel, honeysuckle, poria, coix seed, houttuynia cordata, raw rehmannia, white hyacinth bean, bergamot, bitter almond, oyster, atractylodes, polygonatum, angelica dahurica, dandelion, kelp, turtle shell, donkey-hide gelatin, cornus fruit, yam, codonopsis pilosula, adenophora, and xylitol.

2. The anti-inflammatory and mass-dispersing Chinese medicine composition according to claim 1, characterized in that: The invention comprises the following raw materials by weight: 150-350 parts of Huajuhong, 150-350 parts of honeysuckle, 100-300 parts of Poria, 100-300 parts of Coix seeds, 100-300 parts of Houttuynia cordata, 30-120 parts of Radix Rehmanniae, 30-120 parts of White Lablab, 30-120 parts of Citron, 30-120 parts of Bitter Apricot, 30-120 parts of Oyster, 30-120 parts of Atractylodes macrocephala, 30-120 parts of Polygonatum sibiricum, 30-120 parts of Angelica dahurica, 20-80 parts of Taraxacum, 20-80 parts of Kelp, 20-80 parts of Turtle Shell, 5-60 parts of Donkey-hide Gelatin, 5-60 parts of Cornus officinalis, 5-60 parts of Chinese Yam, 5-30 parts of Codonopsis pilosula, 5-30 parts of Adenophora adenophora, and 5-30 parts of xylitol.

3. The anti-inflammatory and mass-dispersing Chinese medicine composition according to claim 1, characterized in that: The invention comprises the following raw materials by weight: 200-300 parts of Huajuhong, 200-300 parts of honeysuckle, 150-250 parts of Poria, 150-250 parts of Coix seeds, 150-250 parts of Houttuynia cordata, 50-100 parts of Radix Rehmanniae, 50-100 parts of White Lablab, 50-100 parts of Citron, 50-100 parts of Bitter Apricot, 50-100 parts of Oyster, 50-100 parts of Atractylodes macrocephala, 50-100 parts of Polygonatum sibiricum, 50-100 parts of Angelica dahurica, 30-70 parts of Taraxacum mongolicum, 30-70 parts of Kelp, 30-70 parts of Turtle Shell, 10-50 parts of Donkey-hide Gelatin, 10-50 parts of Cornus officinalis, 10-50 parts of Chinese Yam, 10-20 parts of Codonopsis pilosula, 10-20 parts of Adenophora adenophora, and 10-20 parts of xylitol.

4. The anti-inflammatory and mass-dispersing Chinese medicine composition according to claim 1, characterized in that: The invention comprises the following raw materials by weight: 200-250 parts of Huajuhong, 250-300 parts of honeysuckle, 180-220 parts of Poria, 180-220 parts of Coix seeds, 180-220 parts of Houttuynia cordata, 50-80 parts of Radix Rehmanniae, 50-80 parts of White Lablab, 50-80 parts of Citron, 50-80 parts of Bitter Apricot, 50-80 parts of Oyster, 50-80 parts of Atractylodes macrocephala, 50-80 parts of Polygonatum sibiricum, 50-80 parts of Angelica dahurica, 30-60 parts of Taraxacum mongolicum, 30-60 parts of Kelp, 30-60 parts of Turtle Shell, 10-30 parts of Donkey-hide gelatin, 10-30 parts of Cornus officinalis, 10-30 parts of Chinese yam, 10-15 parts of Codonopsis pilosula, 10-15 parts of Adenophora adenophora, and 10-15 parts of xylitol.

5. Use of the anti-inflammatory and stagnation-dispersing Chinese medicinal composition according to any one of claims 1 to 4 in the preparation of anti-inflammatory and stagnation-dispersing drugs.

6. An anti-inflammatory and mass-dispersing drug, characterized in that: The invention comprises the anti-inflammatory and knot-dispersing traditional Chinese medicine composition according to any one of claims 1 to 4 and pharmaceutically acceptable auxiliary materials.

7. The anti-inflammatory and mass-dispersing drug according to claim 6, characterized in that: The dosage form of the medicine is Chinese medicine decoction, decoction, granules, pills, capsules, tablets, tea, suspension, powder or oral solution.

8. The method for preparing the anti-inflammatory and mass-dispersing drug according to claim 7, characterized in that: The medicine is a pill, and its preparation method is as follows: Step 1, weighing the raw materials according to the weight ratio, cleaning, drying, cutting, crushing, sieving, and mixing evenly; Step 2: Soak the raw materials in clean water for 0.5 to 1 hour, heat to 80-100°C, and boil repeatedly for 1 to 3 times, with the weight of water added each time being 10 to 20 times the total weight of all raw materials, and the heating and boiling time is 1.5 to 2 hours, and finally the filtrate is combined; Step 3, after the filtrate is allowed to settle, the supernatant is taken out, concentrated into a clear paste composition, spray-dried to obtain a clear paste powder, added with refined honey, and made into pills according to conventional processes.

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