Coding method for endowing material system with specific response external field effect

Abstract

The invention provides a coding method for endowing a material system with a specific response external field effect. The method comprises the following steps: setting a password according to an application scene; coding the component according to the password to obtain a coded component; if the actual external field effect is the specific external field effect, decoding the coding component; the particular outfield action is used to cause the coding component to make an outfield response. The method solves the problems of insufficient response specificity and single application scene in the stimuli-responsive material.

Description

Technical Field

[0001] The present invention relates to the field of material science, and in particular to a coding method for endowing a material system with specific response to an external field effect. Background Art

[0002] Stimuli-responsive materials are an advanced material in the field of materials science. They are mainly used to produce physical or chemical changes and release contents at the target location after being stimulated, and function at the target location in an on-demand and controllable manner. They have a wide range of applications in fields such as biomedicine and energy.

[0003] Stimuli-responsive materials function by responding to external stimuli. In practical applications, due to the lack of specificity of the material system in response to stimuli, the material's response may occur in unexpected circumstances, affecting the accuracy and controllability of the function on demand. In addition, current stimuli-responsive materials are often designed to be applied only to a single application scenario. Therefore, it is necessary to design a coding method that gives the material system a specific response to external fields. Summary of the invention

[0004] The purpose of the present invention is to provide a coding method for endowing a material system with specific response to external field effects, so as to solve the problems of insufficient response specificity and single application scenario in stimulus-responsive materials.

[0005] To achieve the above object, the present invention provides the following solutions:

[0006] A method for encoding a material system to specifically respond to an external field comprises the following steps:

[0007] Set a password according to the application scenario; the password is a restriction instruction; the specific content of the restriction instruction is: to make the restricted target only respond to specific external field effects;

[0008] Encode the component according to the password to obtain the encoded component;

[0009] If the actual external field effect is a specific external field effect, the coding component is decoded; the specific external field effect is used to make the coding component respond to the external field.

[0010] Optionally, the components include: metals, inorganic non-metals, polymers and composite materials.

[0011] Optionally, the components are encoded according to the selected password to obtain the encoded components, and the specific steps are: structural modification and modification operations are performed on the components to obtain the encoded components, and the encoded components are given the function of responding to specific external fields.

[0012] Optionally, the structural modification includes: changing the structure of the component to solid, hollow, porous, multi-layer or core-shell; the modification includes: machining, heat treatment, cross-linking, grafting, coating, filling and blending.

[0013] Optionally, the structural modification and modification operations on the components also include: compounding the components with the contents and the substrate.

[0014] Optionally, the specific external field effect includes: a specific combination of a single external field effect and a specific combination of different external field effects.

[0015] Optionally, the external field effect includes: an external force field of a specific magnitude or a specific direction, light waves of a specific wavelength or a specific energy, sound waves of a specific frequency, an electric field of a specific frequency, an electric current of a specific magnitude, and a magnetic field of a specific frequency and intensity.

[0016] Optionally, the external field response includes: releasing contents, vibrating or breaking, increasing temperature and chemical reaction.

[0017] According to the specific embodiments provided by the present invention, the present invention discloses the following technical effects: the coding method for giving a material system a specific response to an external field provided by the present invention comprises: selecting a password in a password library according to different application scenarios; encoding a component according to the selected password to obtain a coded component; if the actual external field effect is a specific external field effect, decoding the coded component; the specific external field effect is used to make the coded component respond to an external field. This method solves the problem of insufficient response specificity and single application scenario in stimulus-responsive materials. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative labor.

[0019] Figure 1 This is a flow chart of a coding method for imparting specific response of a material system to an external field according to an embodiment of the present invention. DETAILED DESCRIPTION

[0020] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0021] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and understandable, the present invention is further described in detail below with reference to the accompanying drawings and specific embodiments.

[0022] like Figure 1 As shown, an embodiment of the present invention provides a coding method for giving a material system a specific response to an external field, comprising the following steps:

[0023] Step 100: Set a password according to the application scenario.

[0024] Specifically, the password is a restriction instruction; the specific content of the restriction instruction is: to make the restricted target only respond to specific external field effects.

[0025] Step 200: Encode the components according to the code to obtain the encoded components. The specific steps are: structurally modify and modify the components to obtain the encoded components, and give the encoded components the function of responding to specific external fields; the components include: metals, inorganic non-metals, polymers and composite materials.

[0026] Specifically, structural modification includes: changing the structure of the components to solid, hollow, porous, multi-layer or core-shell; modification includes: mechanical processing, heat treatment, cross-linking, grafting, coating, filling and blending.

[0027] More specifically, structural modification and modification operations on components also include: compounding the components with contents and substrates; contents include: drugs, biological molecules, small molecules of chemical substances, polymers and particles; substrates include: metals, inorganic non-metals, polymers and composite materials.

[0028] Step 300: If the actual external field effect is a specific external field effect, the coding component is decoded.

[0029] Specifically, the specific external field effect includes: a specific combination of a single external field effect and a specific combination of different external field effects. The specific external field effect is used to make the coding element perform an external field response.

[0030] More specifically, the specific combination of external field effects includes the sequence of actions of different external fields or the superposition of different external field effects; external field effects include: external force fields of specific magnitude or specific direction, light waves of specific wavelength or specific energy, sound waves of specific frequency, electric fields of specific frequency, currents of specific magnitude, and magnetic fields of specific frequency and intensity.

[0031] More specifically, external field responses include: releasing contents, vibrating or even breaking, increasing temperature, and chemical reactions.

[0032] Embodiment 1 of the present invention is to realize the controllable on-demand degradation of inorganic non-metallic materials by giving the material system specific response to the coding method of the external field effect, and the specific implementation method is: first, set the ultrasonic external field stimulation of 50kHz and 200kHz as a password, so that the target can only respond under the ultrasonic external field stimulation of 50kHz and 200kHz respectively. Secondly, prepare amorphous calcium carbonate as a shell, and load two kinds of core-shell particles of high concentration sodium hydroxide solution respectively, and form two kinds of coding components. Wherein, the shell thickness of the two coding components is different, and the natural frequency is 50kHz and 200kHz respectively, which can only respond to the ultrasonic action of 50kHz and 200kHz respectively, and resonate to break and release the sodium hydroxide solution. Finally, the above two coding components were added to the left and right areas of the inorganic silica glass respectively. After the glass was subjected to ultrasonic stimulation at a frequency of 50kHz, the coding components in the left area were broken, releasing the high concentration of sodium hydroxide solution therein and reacting with the glass, thereby degrading the glass on the left side; after the glass was subjected to ultrasonic stimulation at a frequency of 200kHz, the coding components in the right area were broken, releasing the high concentration of sodium hydroxide solution therein and reacting with the glass, thereby degrading the glass on the right side.

[0033] Embodiment 2 of the present invention is to realize the controllable on-demand degradation of polymer materials by the coding method of giving material system specific response external field effect, and the specific implementation method is: first, set 111kHz, 16mT and 523kHz, 8mT alternating magnetic field external field stimulation as password, so that the target can only respond under the alternating magnetic field external field stimulation of 111kHz, 16mT and 523kHz, 8mT respectively. Secondly, prepare paraffin as shell, and respectively load two kinds of core-shell particles of ethylene glycol diethyl ether diamine tetraacetic acid (EGTA) calcium ion chelator, and two kinds of superparamagnetic iron oxide nanoparticles are added to the paraffin shell of two kinds of core-shell particles respectively, forming two kinds of coding components. Wherein, the magnetic field corresponding to the maximum magnetocaloric effect of two kinds of coding components is 111kHz, 16mT and 523kHz, 8mT respectively, and can only be 111kHz, 16mT and 523kHz, 8mT respectively. The magnetic field is raised to the highest temperature under the magnetic field effect of 8mT. Finally, the above two coding components were added to the left and right areas of calcium alginate hydrogel respectively. After the hydrogel was stimulated by a magnetic field of 111kHz and 16mT, the temperature of the left area increased significantly and the paraffin shell melted, releasing the EGTA therein and degrading the hydrogel on the left side; after the hydrogel was stimulated by a magnetic field of 523kHz and 8mT, the temperature of the right area increased significantly and the paraffin shell melted, releasing the EGTA therein and degrading the hydrogel on the right side.

[0034] Embodiment 3 of the present invention is to realize the controllable on-demand degradation of metal materials by giving the material system a coding method that specifically responds to the external field effect, and the specific implementation method is: First, set 111kHz, 16mT, 523kHz, 8mT and 987kHz, 10mT alternating magnetic field external field stimulation as a password, so that the target can only respond under the alternating magnetic field external field stimulation of 111kHz, 16mT, 523kHz, 8mT and 987kHz, 10mT. Secondly, prepare paraffin as a shell, and load three kinds of core-shell particles of dilute sulfuric acid solution respectively, and add three kinds of superparamagnetic iron oxide nanoparticles to the paraffin shell layer of the three kinds of core-shell particles respectively, and form three kinds of coding components. Among them, the magnetic field corresponding to the maximum magnetocaloric effect of the three coding components is 111kHz, 16mT, 523kHz, 8mT and 987kHz, 10mT respectively, and can only be raised to the highest temperature under the magnetic field of 111kHz, 16mT, 523kHz, 8mT and 987kHz, 10mT respectively. Finally, the above three code elements were added to the upper, middle and lower regions of the titanium block. After the titanium block was stimulated by a magnetic field of 111kHz and 16mT, the temperature of the upper layer increased significantly, melting the paraffin shell, releasing the dilute sulfuric acid therein, and degrading the upper titanium block; after the titanium block was stimulated by a magnetic field of 523kHz and 8mT, the temperature of the middle layer increased significantly, melting the paraffin shell, releasing the dilute sulfuric acid therein, and degrading the middle titanium block; after the titanium block was stimulated by a magnetic field of 987kHz and 10mT, the temperature of the lower layer increased significantly, melting the paraffin shell, releasing the dilute sulfuric acid therein, and degrading the lower titanium block.

[0035] Embodiment 4 of the present invention is to realize the performance regulation of material mechanics by the coding method of giving material system specific response to external field effect, and the specific implementation method is: first, set 111kHz, 16mT alternating magnetic field external field stimulation and 1065nm laser external field stimulation as passwords, so that the target can only respond under 111kHz, 16mT alternating magnetic field external field and 1065nm laser external field stimulation. Secondly, paraffin is prepared as a shell, and core-shell particles with EGTA calcium ion chelator are loaded, and superparamagnetic iron oxide nanoparticles are added to the paraffin shell of the core-shell particles to form coding components. Wherein, the magnetic field corresponding to the maximum magnetothermal effect of the coding component is 111kHz, 16mT. Polycaprolactone is prepared as a shell, and calcium chloride is loaded. Nanogold rods are added to the polycaprolactone shell of the core-shell particles to form coding components, wherein the light wavelength corresponding to the maximum photothermal effect of the coding component is 1065nm. The above two coding components can only be raised to the highest temperature under the action of a magnetic field of 111kHz, 16mT and irradiation of light with a wavelength of 1065nm. Finally, the above two coding components are placed in a calcium alginate hydrogel. After the hydrogel is stimulated by a magnetic field with a frequency of 111kHz, 16mT, the temperature of the paraffin particles increases significantly, the paraffin shell is melted, the EGTA therein is released, the hydrogel is degraded, and the mechanical properties of the hydrogel decrease; after the hydrogel is irradiated with light with a wavelength of 1065nm, the temperature of the polycaprolactone particles increases significantly, the polycaprolactone shell is melted, the calcium chloride therein is released, the cross-linking density is increased, and the mechanical properties of the hydrogel increase.

[0036] Embodiment 5 of the present invention is to realize the degradability of bone repair materials by giving the material system a coding method that specifically responds to the external field effect, and the specific implementation method is: First, set 111kHz, 16mT alternating magnetic field external field stimulation and 20kHz ultrasonic external field stimulation as passwords, so that the target can only respond under 111kHz, 16mT alternating magnetic field external field and 20kHz ultrasonic external field stimulation. Secondly, prepare mesoporous silica particles with a particle size of 5μm (natural frequency is 20kHz), and load strontium carbonate to form coding components; prepare paraffin as a shell, and load EGTA core-shell particles, add superparamagnetic iron oxide nanoparticles to the paraffin shell layer, and form coding components. Among them, the magnetic field corresponding to the maximum magnetocaloric effect of the coding component is 111kHz, 16mT, and the silica particles can only respond to the ultrasonic effect of 20kHz, and resonance causes particle fragmentation; paraffin particles can only be raised to the highest temperature under the magnetic field of 111kHz, 16mT. Finally, the above two coding components are placed in calcium alginate hydrogel, and the hydrogel is given ultrasonic stimulation at a frequency of 20kHz. The silica particle coding component will respond and release the strontium carbonate therein. The strontium ion can increase the activity of alkaline phosphatase and the formation of calcium nodules, thereby promoting bone regeneration. After giving the hydrogel a magnetic field stimulation with a frequency of 111kHz and 16mT, the paraffin particle coding component will respond, the temperature will rise significantly, the paraffin shell will melt, the EGTA therein will be released, the calcium ions of the calcium alginate hydrogel will be chelated, the cross-linking structure of the hydrogel will be destroyed, and the hydrogel will be degraded.

[0037] Embodiment 6 of the present invention is to realize the treatment of tumor by the coding method of giving material system specific response to external field effect, and the specific implementation method is: first, set 111kHz, 16mT alternating magnetic field external field stimulation and 1MHz ultrasonic external field stimulation as password, so that the target can only respond under 111kHz, 16mT alternating magnetic field external field and 1MHz ultrasonic external field stimulation respectively. Secondly, prepare mesoporous silica particles (natural frequency is 1MHz) with a particle size of 100nm, and load chemotherapy drug adriamycin to form coding components; prepare paraffin as a shell, and load the core-shell particles of anti-inflammatory drugs and anti-inflammatory peptides, the core-shell particle size is 200nm, and superparamagnetic iron oxide nanoparticles (the magnetic field corresponding to the maximum magnetocaloric effect is 111kHz, 16mT) are added to the paraffin shell layer to form coding components. Wherein, silica particles can only respond to the ultrasonic action of 1MHz, produce resonance and cause particle fragmentation, and paraffin particles can only be raised to the highest temperature under the magnetic field of 111kHz, 16mT. Finally, the above two coding components were injected into mice with solid tumors. Due to the passive targeting effect, the particles eventually gathered in the tumor area. After the tumor site was stimulated by ultrasound at a frequency of 1MHz, the silica particle coding components responded, releasing the doxorubicin therein to kill tumor cells; after the tumor site was stimulated by a magnetic field at a frequency of 111kHz and 16mT, the paraffin particle coding components responded, the temperature rose significantly, melting the paraffin shell, releasing the anti-inflammatory peptides therein, and eliminating the inflammatory response caused by chemotherapy.

[0038] Embodiment 7 of the present invention is to realize the treatment of wound inflammation and infection by giving material system specific response to external field effect coding method, and the specific implementation method is: first, set 20kHz and 1MHz ultrasonic external field stimulation as password, so that the target can only respond under 20kHz and 1MHz ultrasonic external field stimulation respectively. Secondly, prepare mesoporous silica particles with a particle size of 5μm (natural frequency is 20kHz), and load anti-inflammatory drug anti-inflammatory peptides to form coding components; prepare mesoporous polystyrene particles with a particle size of 100nm (natural frequency is 1MHz), and load antibiotic vancomycin to form coding components. Among them, the two coding components can only respond to the ultrasonic effects of 20kHz and 1MHz respectively, generate resonance and break the release drug. Finally, the above two coding components are placed in a wound dressing, and the dressing is used at the wound site to monitor the wound in real time. If inflammation occurs, ultrasonic stimulation with a frequency of 20kHz is applied to the dressing, and the mesoporous silica particles in the dressing release the anti-inflammatory peptides they carry to respond to the inflammatory response; if infection occurs, ultrasonic stimulation with a frequency of 1MHz is applied to the dressing, and the mesoporous polystyrene particles in the dressing release the vancomycin they carry for sterilization.

[0039] The beneficial effects of the present invention are as follows:

[0040] 1) Improved response specificity in stimuli-responsive materials;

[0041] 2) It enables responsive materials to respond precisely as needed and can be applied in a variety of scenarios.

[0042] The various embodiments in this specification are described in a progressive manner, and each embodiment focuses on the differences from other embodiments. The same or similar parts between the various embodiments can be referenced to each other.

[0043] The present invention uses specific examples to illustrate the principles and implementation methods of the present invention. The above examples are only used to help understand the method and core ideas of the present invention. At the same time, for those skilled in the art, according to the ideas of the present invention, there will be changes in the specific implementation methods and application scope. In summary, the content of this specification should not be understood as limiting the present invention.

Claims

1. A method for encoding a material system to specifically respond to an external field, characterized in that: The steps include: A password is set according to the application scenario; the password is a restriction instruction; the specific content of the restriction instruction is: to restrict the target to respond only to a specific external field effect; Encoding the component according to the password to obtain the encoded component; If the actual external field effect is a specific external field effect, the coding component is decoded; the specific external field effect is used to make the coding component respond to the external field.

2. The encoding method for imparting specific response to external field action to a material system according to claim 1, characterized in that: The components include: metals, inorganic non-metals, polymers and composite materials.

3. The encoding method for imparting specific response to external field to a material system according to claim 1, characterized in that: The component is encoded according to the selected password to obtain the encoded component. The specific steps are: structural modification and modification operations are performed on the component to obtain the encoded component, and the encoded component is given the function of responding to the specific external field.

4. The encoding method for imparting specific response to external field to a material system according to claim 3, characterized in that: The structural modification includes: changing the structure of the component to solid, hollow, multi-hole, multi-layer or core-shell; the modification includes: mechanical processing, heat treatment, cross-linking, grafting, coating, filling and blending.

5. The encoding method for imparting specific response to external field to a material system according to claim 3, characterized in that: The structural modification and property modification operations of the components also include: compounding the components with the contents and the substrate.

6. The encoding method for imparting specific response to external field to a material system according to claim 1, characterized in that: The specific external field effects include: a specific combination of a single external field effect and a specific combination of different external field effects.

7. The encoding method for imparting specific response to external field to a material system according to claim 6, characterized in that: The external field effects include: an external force field of a specific size or a specific direction, light waves of a specific wavelength or a specific energy, sound waves of a specific frequency, an electric field of a specific frequency, an electric current of a specific size, and a magnetic field of a specific frequency and intensity.

8. The encoding method for imparting specific response to external field to a material system according to claim 5, characterized in that: The external field response includes: releasing the contents, vibrating or breaking, increasing temperature and chemical reaction.

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