Traditional Chinese medicine composition for treating fatty liver and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine composition for treating fatty liver, which is prepared from the following raw material medicines in parts by weight: 15-25 parts of semen cuscutae, 12-16 parts of cortex eucommiae, 8-12 parts of caulis spatholobi, 5-15 parts of radix morindae officinalis, 20-30 parts of fructus lycii, 10-20 parts of lucid ganoderma, 20-30 parts of rhizoma polygonati, 10-20 parts of radix notoginseng, 15-25 parts of rhizoma dioscoreae, 10-20 parts of radix salviae miltiorrhizae, 14-18 parts of fructus trichosanthis, 20-30 parts of semen sterculiae lychnophorae, 10-20 parts of fructus perillae, 8-12 parts of seaweed, 15-25 parts of pericarpium citri reticulatae viride and the like. The traditional Chinese medicine composition can nourish liver and kidney, tonify qi and activate blood, reduce phlegm and remove stasis, sooth the liver and strengthen the spleen, sooth the liver and regulate qi, clear heat and reduce phlegm, and has a remarkable effect on treating stasis and turbidity internal stagnation type fatty liver.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicines, and in particular to a preparation method, a traditional Chinese medicine preparation and application of a traditional Chinese medicine composition for treating fatty liver. Background Art

[0002] In recent years, with the improvement of people's living standards and changes in lifestyle, the number of overweight or obese patients has gradually increased. my country's diet is mainly based on "big fish and big meat", coupled with little exercise, it is easy to suffer from this disease. Since fatty liver is reversible, patients need to actively treat it after being found to have the disease. The treatment of fatty liver mainly includes two categories: drug therapy and non-drug therapy. Among them, drug therapy has the most significant effect. In order to better treat fatty liver, it is necessary to first understand the main cause of fatty liver disease, so as to take effective measures against the cause. Among the many factors that cause fatty liver, long-term and large-scale drinking of sugary drinks is an important one. One of the important factors is that a large amount of carbohydrate intake can easily cause an increase in insulin levels in the body and activate certain factors to inhibit fatty acid oxidation, which increases the body's demand for energy. By taking more food to meet the body's energy supply, it eventually leads to continuous weight gain, abnormal fat metabolism and fatty liver. However, the existing treatment options do not fundamentally achieve the purpose of prevention and cure, and usually only relieve symptoms. Moreover, most of the current drugs have complex ingredients, many side effects and high costs. How to provide a Chinese patent medicine with low irritation, no obvious drug side effects and better prevention and treatment of fatty liver is a difficult problem currently faced.

[0003] Fatty liver, also known as fatty liver disease, refers to a disease caused by excessive fat accumulation in liver cells due to various reasons. The main pathological feature is diffuse fatty changes in liver cells. Clinical symptoms include discomfort in the right upper abdomen, fatigue and poor appetite. According to the degree of fatty changes in liver cells, fatty liver can be divided into mild, moderate and severe. The causes of fatty liver are mainly related to obesity, hypothyroidism and hypertension.

[0004] Traditional Chinese medicine believes that fatty liver belongs to the category of accumulation and flank pain. Traditional Chinese medicine believes that when the liver fails to release, the spleen fails to function properly, and phlegm and turbidity accumulate in the liver, it will cause lumps and pain under the ribs. This is called liver distension in traditional Chinese medicine, which is similar to fatty liver in Western medicine. Traditional Chinese medicine believes that overeating fatty and sweet foods, drinking too much, emotional disorders, damp-heat epidemic toxins, long-term illness and physical weakness often induce this disease. Chinese patent document CN201410539945.0, published on October 14, 2014, discloses a traditional Chinese medicine composition for the treatment of non-alcoholic fatty liver disease and its application. The traditional Chinese medicine composition is made of the following important raw materials in parts by weight: 330-340 parts of Gynostemma pentaphyllum, 330-340 parts of stir-fried Atractylodes macrocephala, 330-340 parts of Salvia miltiorrhiza, 490-510 parts of Alisma orientalis, 330-340 parts of processed Pinellia ternata, 330-340 parts of lotus leaves, 100 parts of Xuanming powder 60-170 parts, 330-340 parts of stir-fried dried orange peel, 330-340 parts of hawthorn; Chinese patent document CN201310404423.5, published on December 25, 2013, discloses a Chinese medicine pill for treating hyperlipidemia, which is made of the following raw materials in weight ratio: whole Trichosanthes, Arisaema consanguineum, Pinellia ternata, stir-fried Rhizoma Alismatis, Poria, Raw Hawthorn, processed Polygonum multiflorum, Fructus Laevigatae, Salvia miltiorrhizae, Cassiae praeparata, Albizzia julibrissin, Lotus leaf, Gynostemma pentaphyllum, processed Polygonatum sibiricum. None of the above documents have a theoretical basis in traditional Chinese medicine, and there is no good solution at present. Summary of the invention

[0005] In view of the deficiencies in the prior art, the purpose of the present invention is to develop a Chinese medicine composition for treating fatty liver and a preparation method thereof. The Chinese medicine composition has a unique and reasonable compatibility, no toxic side effects, obvious therapeutic effect, and a simple and reasonable preparation method.

[0006] A traditional Chinese medicine composition for treating fatty liver is prepared from the following raw materials in parts by weight: 15-25 parts of dodder seeds, 12-16 parts of eucommia bark, 8-12 parts of millettia reticulata, 5-15 parts of morinda officinalis, 20-30 parts of wolfberry, 10-20 parts of ganoderma lucidum, 20-30 parts of polygonatum, 10-20 parts of notoginseng, 15-25 parts of yam, 10-20 parts of salvia miltiorrhiza, 14-18 parts of trichosanthes, 20-30 parts of sterculia lychnophora, 10-20 parts of perilla seeds, 8-12 parts of seaweed, 15-25 parts of green peel, 10-20 parts of tangerine peel, 8-12 parts of cyperus rotundus, 12-16 parts of bupleurum, 20-30 parts of astragalus, 10-20 parts of kudzu root, 15-25 parts of ligusticum chuanxiong, 10-20 parts of peucedanum, 6-10 parts of fritillaria cirrhosa, and 8-12 parts of arisaema ciliata.

[0007] The traditional Chinese medicine composition for treating fatty liver is prepared from the following raw materials in parts by weight: 20 parts of Cuscuta seeds, 14 parts of Eucommia ulmoides, 10 parts of Millettia spatholobi, 10 parts of Morinda officinalis, 25 parts of Lycium barbarum, 15 parts of Ganoderma lucidum, 25 parts of Polygonatum sibiricum, 15 parts of Panax notoginseng, 20 parts of Dioscorea opposita, 15 parts of Salvia miltiorrhiza, 16 parts of Trichosanthes kirilowii, 25 parts of Sterculia lychnophora, 15 parts of Perilla seeds, 10 parts of Sargassum, 20 parts of Citrus aurantium, 15 parts of Tangerine peel, 10 parts of Cyperus rotundus, 14 parts of Bupleurum chinense, 25 parts of Astragalus membranaceus, 20 parts of Pueraria root, 20 parts of Ligusticum chuanxiong, 15 parts of Peucedanum peucedanum, 8 parts of Fritillaria cirrhosa, and 10 parts of Arisaema ciliata.

[0008] The traditional Chinese medicine composition for treating fatty liver is prepared from the following raw materials in parts by weight: 15 parts of Cuscuta seeds, 16 parts of Eucommia bark, 8 parts of Millettia spatholobi, 15 parts of Morinda officinalis, 20 parts of Lycium barbarum, 20 parts of Ganoderma lucidum, 20 parts of Polygonatum sibiricum, 20 parts of Panax notoginseng, 15 parts of Dioscorea opposita, 20 parts of Salvia miltiorrhiza, 14 parts of Trichosanthes kirilowii, 30 parts of Sterculia lychnophora, 10 parts of Perilla seeds, 12 parts of Sargassum, 15 parts of Citrus aurantium, 20 parts of Tangerine peel, 8 parts of Cyperus rotundus, 16 parts of Bupleurum, 20 parts of Astragalus, 20 parts of Pueraria root, 15 parts of Ligusticum chuanxiong, 20 parts of Peucedanum peucedanum, 6 parts of Fritillaria cirrhosa, and 12 parts of Arisaema ciliata.

[0009] The traditional Chinese medicine composition for treating fatty liver is prepared from the following raw materials in parts by weight: 25 parts of Cuscuta seeds, 12 parts of Eucommia ulmoides, 12 parts of Millettia spatholobi, 5 parts of Morinda officinalis, 30 parts of Lycium barbarum, 10 parts of Ganoderma lucidum, 30 parts of Polygonatum sibiricum, 10 parts of Panax notoginseng, 25 parts of Dioscorea opposita, 10 parts of Salvia miltiorrhiza, 18 parts of Trichosanthes kirilowii, 20 parts of Sterculia lychnophora, 20 parts of Perilla seeds, 8 parts of Sargassum, 25 parts of Citrus aurantium, 10 parts of Citrus reticulata, 12 parts of Cyperus rotundus, 12 parts of Bupleurum chinense, 25 parts of Ligusticum chuanxiong, 10 parts of Peucedanum peucedanum, 30 parts of Astragalus membranaceus, 10 parts of Pueraria root, 10 parts of Fritillaria cirrhosa, and 8 parts of Arisaema ciliata.

[0010] The Chinese medicine composition for treating fatty liver has a preparation method as follows: the above medicinal materials are weighed according to the dosage, crushed and passed through a 20-mesh sieve, and water 12 times the weight of the medicinal materials is added to immerse the medicinal materials. After soaking for 3 hours, the mixture is heated to boiling and decocted for 2 hours. The decoction is taken, and the residue is decocted 2-3 times according to the method. The decoctions are combined, filtered, evaporated and concentrated to a relative density of 1.2 at 25°C, cooled, added with 1.5 times the amount of ethanol, fully mixed, left overnight, the supernatant is taken, the precipitate is washed with a small amount of 50% ethanol, the washing liquid is combined with the filtrate, concentrated under reduced pressure to recover the ethanol, concentrated, cooled and allowed to stand, filtered, vacuum concentrated at low temperature to a thick paste, the thick paste has a specific gravity of 1.33, and spray-dried to obtain an extract powder, which is added with auxiliary materials to prepare a preparation.

[0011] The traditional Chinese medicine composition for treating fatty liver is prepared in the form of pills, tablets, capsules, granules, oral liquids and pastes.

[0012] In the traditional Chinese medicine composition for treating fatty liver, the concentration of the ethanol solution is 65-75%.

[0013] The temperature of the reduced pressure concentration in the traditional Chinese medicine composition for treating fatty liver is 60-80°C.

[0014] The traditional Chinese medicine composition for treating fatty liver is used in preparing medicine for treating fatty liver.

[0015] The Chinese medicine composition for treating fatty liver is used in preparing a drug for treating fatty liver, and the fatty liver belongs to the type of blood stasis and internal stagnation.

[0016] Fatty liver belongs to the category of "flank pain", "fat turbidity" and "phlegm turbidity" in traditional Chinese medicine. It is divided into four types: phlegm stasis blocking the collaterals, liver depression and blood stasis, spleen dysfunction, and stasis turbidity stagnation. Among them, stasis turbidity stagnation is the most common. It is generally caused by the original diabetes, yin deficiency and fire excess, chronic persistent hepatitis, swelling under the ribs, refusal to press, decreased appetite and fatigue, dark purple tongue with ecchymosis, thin white fur, and fine and wiry pulse. Its etiology and pathogenesis: phlegm and dampness blocking, qi stagnation and blood stasis, phlegm turbidity, and blood stasis blocking the liver collaterals, resulting in tingling and swelling in the liver area and the formation of fatty liver. "Compendium of Materia Medica" states: "Overeating, liking to eat oily noodles and pork fat... stagnation is caused by phlegm." "Clinical Guide Medical Cases·Dampness" states: "If dampness is generated from within, it must be because the person has consumed too much rich food and wine." "Introduction to Medicine" also states: "Those who like to eat rich food will produce phlegm. Modern Chinese medicine believes that if you often eat too much or like rich food such as sorghum, water and grain cannot be transformed into essence, but instead become phlegm and fat, which damages the spleen and stomach, causing abnormal spleen and stomach transportation and transformation, water and dampness stagnation, phlegm and turbidity to be generated internally, which accumulate and turn into heat, blocking the Qi mechanism, Qi stagnation and blood stasis, causing Qi, blood, phlegm and turbidity to fight each other and accumulate in the liver, causing this disease. If only resolving phlegm and removing blood stasis cannot achieve good results, because water cannot contain wood, the liver fails to disperse, the spleen is weak and fails to transport and transform, and phlegm and blood stasis block the liver, "Suwen·Ancient Innocence" says: "At the age of forty, the Yin Qi is halved, and the daily life is declining. "When the kidney qi of the elderly gradually becomes weak, water does not contain wood, or fire does not warm the earth, the liver fails to release and the spleen fails to function properly, fluid accumulates and fat clots in the blood vessels, causing obesity, and accumulation in the liver causes fatty liver. The present invention adopts nourishing the liver and kidney as the fundamental method.

[0017] The main pathogenic cause of turbidity and internal stagnation type is phlegm and blood stasis, qi stagnation and blood stasis. The present invention adopts the method of invigorating qi and activating blood circulation, and because of "Ancient and Modern Medical Mirror·Flanky Pain": "Flanky pain, ... or phlegm accumulation flows into the blood, and fights with the blood, all of which are pains ... The treatment should be based on dispersing stagnation and smoothing qi, resolving phlegm and harmonizing blood." Wu Jutong also said that "the depression of liver qi, phlegm and blood stasis blocking the collaterals" believes that this disease is related to phlegm dampness and blood stasis, and then cooperates with the method of resolving phlegm and removing blood stasis. "Suwen" said: "Drinking enters the stomach, wandering and overflowing essence, and transporting to the spleen, the spleen disperses essence, and returns to the lungs ... "The digestion and absorption of food is realized in the process of spleen transporting water and grain essence. Therefore, the liver and spleen are soothed to promote food metabolism.

[0018] Patients with fatty liver usually have the problem of liver qi stagnation. The liver stores blood. When liver qi stagnates, blood will be blocked, qi and blood will not flow smoothly, and liver disease will occur. Therefore, the treatment of fatty liver should be to soothe the liver and regulate qi. When the liver fails to soothe and release qi, the qi mechanism is out of balance, and the distribution of qi, blood, body fluid and fluid in the whole body is abnormal, which leads to the endogenous generation of phlegm and dampness, which turns into heat. The course of the disease becomes blood stasis over time. The pathological factors such as phlegm, dampness, blood stasis and heat are stuck with each other, leading to the endogenous generation of turbid toxins. The method is to clear away heat, dispel dampness and resolve phlegm.

[0019] The present invention adopts Cuscuta chinensis, Eucommia ulmoides, Millettia reticulata, Morinda officinalis, Lycium barbarum, Ganoderma lucidum to nourish liver and kidney as the main medicine; Polygonatum sibiricum, Panax notoginseng, Chinese yam, Salvia miltiorrhiza to invigorate qi and promote blood circulation; Trichosanthes kirilowii, Sterculia lychnophora, Perilla seed, Sargassum to resolve phlegm and remove blood stasis, which are all the assistant medicines; Perilla frutescens, Citrus reticulata, Cyperus rotundus, Bupleurum chinense to soothe the liver and invigorate the spleen, Astragalus membranaceus to invigorate the spleen and replenish the middle, raise yang and lift the sunken, benefit the defense and consolidate the exterior, Pueraria lobata to relieve muscles and reduce fever, promote rash, promote body fluid and quench thirst, raise yang and stop diarrhea, Bupleurum chinense and Chuanxiong to soothe the liver and regulate qi, which are all the adjuvant medicines; Peucedanum chinense The formula is composed of Cuscuta australis, Eucommia ulmoides, Millettia reticulata, Morinda officinalis, Lycium barbarum, Ganoderma lucidum, Polygonatum sibiricum, Panax notoginseng, yam, Salvia miltiorrhiza, Trichosanthes, Sterculia lychnophora, Perilla seed, Sargassum, Green peel, Tangerine peel, Cyperus rotundus, Bupleurum, Astragalus, Pueraria root, Ligusticum chuanxiong, Peucedanum peucedanum, Fritillaria cirrhosa, and Arisaema cinerea. It can nourish the liver and kidney, invigorate qi and promote blood circulation, resolve phlegm and remove blood stasis, soothe the liver and strengthen the spleen, soothe the liver and regulate qi, clear away heat and resolve phlegm, and has significant effect in treating fatty liver with internal stagnation of blood stasis. DETAILED DESCRIPTION

[0020] The present invention will be further described below in conjunction with specific embodiments. It should be understood that these embodiments are only used to illustrate the present invention and are not intended to limit the scope of the present invention. In addition, it should be understood that after reading the content of the present invention, those skilled in the art can make various changes or modifications to the present invention, but these equivalent forms fall within the scope limited by the appended claims of the application equally.

[0021] Example 1: Take 200g of Cuscuta, 140g of Eucommia, 100g of Millettia, 100g of Morinda officinalis, 250g of Lycium barbarum, 150g of Ganoderma lucidum, 250g of Polygonatum, 150g of Panax notoginseng, 200g of Dioscorea opposita, 150g of Salvia miltiorrhiza, 160g of Trichosanthes, 250g of Sterculia lychnophora, 150g of Perilla seed, 100g of Sargassum, 200g of Citrus aurantium, 150g of Cyperus rotundus, 140g of Bupleurum, 250g of Astragalus, 200g of Pueraria root, 200g of Ligusticum chuanxiong, 150g of Peucedanum peucedanum, 80g of Fritillaria cirrhosa, and 100g of Arisaema cinerea. Weigh the above medicinal materials according to the amount and crush them through a 20-mesh sieve. , add 12 times the weight of the medicinal materials in water to immerse the medicinal materials. After soaking for 3 hours, heat to boiling and decoct for 2 hours. Take the decoction, decoct the residue twice according to the method, combine the decoctions, filter, evaporate and concentrate to a relative density of 1.2 at 25°C, add 1.5 times the amount of 75% ethanol after cooling, mix well, let it stand overnight, take the supernatant, wash the precipitate with a small amount of 50% ethanol, combine the washing liquid and the filtrate, concentrate under reduced pressure to recover ethanol, the temperature is 60°C, concentrate, cool and stand, filter, vacuum concentrate at low temperature to a thick paste, the thick paste has a specific gravity of 1.33, spray dry, get the extract powder, add starch, and make granules.

[0022] Example 2: Take 150g of Cuscuta, 160g of Eucommia, 80g of Millettia, 150g of Morinda officinalis, 200g of Lycium barbarum, 200g of Ganoderma lucidum, 200g of Polygonatum, 200g of Panax notoginseng, 150g of Dioscorea opposita, 200g of Salvia miltiorrhiza, 140g of Trichosanthes, 300g of Sterculia lychnophora, 100g of Perilla seed, 120g of Sargassum, 150g of Citrus aurantium, 200g of Tangerine peel, 80g of Cyperus rotundus, 160g of Bupleurum, 200g of Astragalus, 200g of Pueraria root, 150g of Ligusticum chuanxiong, 200g of Peucedanum, 60g of Fritillaria cirrhosa, and 120g of Arisaema cinerea. Weigh the above medicinal materials according to the amount and crush them through a 20-mesh sieve. , add 12 times the weight of the medicinal materials in water to immerse the medicinal materials. After soaking for 3 hours, heat to boiling and decoct for 2 hours. Take the decoction, decoct the residue twice according to the method, combine the decoctions, filter, evaporate and concentrate to a relative density of 1.2 at 25°C, add 1.5 times the amount of 75% ethanol after cooling, mix well, let it stand overnight, take the supernatant, wash the precipitate with a small amount of 50% ethanol, combine the washing liquid and the filtrate, concentrate under reduced pressure to recover ethanol, the temperature is 60°C, concentrate, cool and stand, filter, vacuum concentrate at low temperature to a thick paste, the thick paste has a specific gravity of 1.33, spray dry, get the extract powder, add dextrin, and make tablets.

[0023] Example 3: Take 250g of Cuscuta, 120g of Eucommia, 120g of Millettia, 50g of Morinda officinalis, 300g of Lycium barbarum, 100g of Ganoderma lucidum, 300g of Polygonatum, 100g of Panax notoginseng, 250g of Dioscorea opposita, 100g of Salvia miltiorrhiza, 180g of Trichosanthes, 200g of Sterculia lychnophora, 200g of Perilla seed, 80g of Sargassum, 250g of Citrus aurantium, 100g of Citrus reticulata, 120g of Cyperus rotundus, 120g of Bupleurum, 250g of Ligusticum chuanxiong, 100g of Peucedanum, 300g of Astragalus, 100g of Pueraria root, 100g of Fritillaria cirrhosa, and 80g of Arisaema cinerea. After weighing the above medicinal materials according to the amount, crush them through a 20-mesh sieve, and add The medicinal materials are immersed in water 12 times the weight of the medicinal materials. After soaking for 3 hours, the water is heated to boiling and decocted for 2 hours. The decoction is taken. The medicinal residue is decocted twice according to the method. The decoctions are combined, filtered, evaporated and concentrated to a relative density of 1.2 at 25°C. After cooling, 1.5 times the amount of 75% ethanol is added, mixed thoroughly, and allowed to stand overnight. The supernatant is taken, and the precipitate is washed with a small amount of 50% ethanol. The washing liquid is combined with the filtrate, and after reduced pressure concentration to recover ethanol, the temperature is 60°C, concentrated, cooled and allowed to stand, filtered, and vacuum concentrated to a thick paste with a specific gravity of 1.33. Spray drying is performed to obtain an extract powder, and microcrystalline cellulose is added to make capsules.

[0024] Example 4: Take 200g of Cuscuta, 140g of Eucommia, 100g of Millettia, 100g of Morinda officinalis, 250g of Lycium barbarum, 150g of Ganoderma lucidum, 250g of Polygonatum, 150g of Panax notoginseng, 200g of Dioscorea opposita, 150g of Salvia miltiorrhiza, 160g of Trichosanthes, 250g of Sterculia lychnophora, 150g of Perilla seed, 100g of Sargassum, 200g of Citrus aurantium, 150g of Cyperus rotundus, 140g of Bupleurum, 250g of Astragalus, 200g of Pueraria root, 200g of Ligusticum chuanxiong, 150g of Peucedanum, 80g of Fritillaria cirrhosa, and 100g of Arisaema cinerea. Weigh the above medicinal materials according to the amount and crush them through a 20-mesh sieve. After that, add 12 times the weight of the medicinal materials in water to immerse the medicinal materials. After soaking for 3 hours, heat to boiling and boil for 2 hours. Take the decoction, boil the residue three times according to the method, combine the decoctions, filter, evaporate and concentrate to a relative density of 1.2 at 25°C, add 1.5 times the amount of 65% ethanol after cooling, mix well, let it stand overnight, take the supernatant, wash the precipitate with a small amount of 50% ethanol, combine the washing liquid and the filtrate, concentrate under reduced pressure to recover ethanol, the temperature is 80°C, concentrate, cool and stand, filter, vacuum concentrate at low temperature to a thick paste, the thick paste has a specific gravity of 1.33, spray dry, get the extract powder, add dextrin, and make pills.

[0025] Example 5: Take 200g of Cuscuta, 140g of Eucommia, 100g of Millettia, 100g of Morinda officinalis, 250g of Lycium barbarum, 150g of Ganoderma lucidum, 250g of Polygonatum, 150g of Panax notoginseng, 200g of Dioscorea opposita, 150g of Salvia miltiorrhiza, 160g of Trichosanthes, 250g of Sterculia lychnophora, 150g of Perilla seed, 100g of Sargassum, 200g of Citrus aurantium, 150g of Citrus reticulata, 100g of Cyperus rotundus, 140g of Bupleurum, 250g of Astragalus, 200g of Pueraria root, 200g of Ligusticum chuanxiong, 150g of Peucedanum peucedanum, 80g of Fritillaria cirrhosa, and 100g of Arisaema cinerea. After the amount is weighed, it is crushed through a 20-mesh sieve, and water 12 times the weight of the medicinal materials is added to submerge the medicinal materials. After soaking for 3 hours, it is heated to boiling and decocted for 2 hours. The decoction is taken, and the residue is decocted 3 times according to the method. The decoctions are combined, filtered, evaporated and concentrated to a relative density of 1.2 at 25°C, and 1.5 times the amount of 65% ethanol is added after cooling. Mix well, let it stand overnight, take the supernatant, wash the precipitate with a small amount of 50% ethanol, combine the washing liquid and the filtrate, and concentrate under reduced pressure to recover the ethanol. The temperature is 80°C, concentrated, cooled and allowed to stand. After filtering, vacuum-concentrated at low temperature to a thick paste to make an ointment.

[0026] Example 6: Take 200g of Cuscuta, 140g of Eucommia, 100g of Millettia, 100g of Morinda officinalis, 250g of Lycium barbarum, 150g of Ganoderma lucidum, 250g of Polygonatum, 150g of Panax notoginseng, 200g of Dioscorea opposita, 150g of Salvia miltiorrhiza, 160g of Trichosanthes, 250g of Sterculia lychnophora, 150g of Perilla seed, 100g of Sargassum, 200g of Citrus aurantium, 150g of Citrus reticulata, 100g of Cyperus rotundus, 140g of Bupleurum, 250g of Astragalus, 200g of Pueraria root, 200g of Ligusticum chuanxiong, 150g of Peucedanum peucedanum, 80g of Fritillaria cirrhosa, and 100g of Arisaema cinerea. The medicinal materials are weighed according to the dosage, crushed and passed through a 20-mesh sieve, and water 12 times the weight of the medicinal materials is added to immerse the medicinal materials. After soaking for 3 hours, the mixture is heated to boiling and decocted for 2 hours. The decoction is taken, and the residue is decocted 3 times according to the method. The decoctions are combined, filtered, evaporated and concentrated to a relative density of 1.2 at 25° C., cooled, added with 1.5 times the amount of 65% ethanol, mixed thoroughly, left overnight, the supernatant is taken, the precipitate is washed with a small amount of 50% ethanol, the washing liquid is combined with the filtrate, and after reduced pressure concentration to recover the ethanol, the temperature is 80° C., concentrated, cooled and allowed to stand, filtered, and then an oral solution is prepared.

[0027] Example 7: Lipid-lowering effect of the present invention on hyperlipidemic mice

[0028] After 1 week of adaptive feeding, 40 male SD rats were randomly divided into a normal group (n=10) and a model group (n=30). The rats in the normal group were given ordinary feed, and the rats in the model group were given high-fat feed. The temperature in the feeding room was controlled at 20±2℃, the relative humidity was 60%-70%, the light and dark were 12h each, and the rats were free to drink water and eat. After 3 weeks, the rats were fasted for 12h overnight, blood was collected from the orbital vein, and plasma was separated. The plasma triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) of each rat were measured.

[0029] After successful modeling, the model group rats were randomly divided into a model control group (n=10), a drug administration group according to Example 1 of the present invention (n=10), and a positive drug (Xuezhikang Tablets) administration group (n=10). The above three groups of rats were fed a high-fat diet, and the normal group rats (n=10) were fed a common diet. All rats were free to eat and drink water. In addition, the drug administration group according to Example 1 of the present invention was gavaged, which was equivalent to a crude drug dosage of 10g / (kg·d), and the positive drug (Xuezhikang Tablets) was given at 1g / (kg·d); the normal group and the model control group were given 10mL / (kg·d of normal saline. The administration cycle was 2 weeks.

[0030] The experimental results are shown in Tables 1 and 2:

[0031] Table 1 The lipid-lowering effect of the present invention on hyperlipidemia mice (after three weeks)

[0032] index Normal group Model Group TG (mg / dL) 52.14±4.56 112.46±15.09** TC (mg / dL) 61.47±8.75 85.04±12.57** LDL-c (mg / dL) 7.46±2.12 23.58±4.89** HDL-c (mg / dL) 46.87±6.90 29.35±2.64** ALT(U / L) 9.09±1.45 13.51±2.98** AST(U / L) 11.68±2.04 15.31±2.99**

[0033] *P<0.05, **P<0.01, compared with the normal group at 3 weeks

[0034] Table 2 The lipid-lowering effect of the present invention on hyperlipidemia mice (after five weeks)

[0035] index Normal group Model Group Example 1 Group Positive drug group TG (mg / dL) 45.24±5.76 92.56±12.64** 56.85±5.97## 62.81±11.94## TC (mg / dL) 58.68±8.13 97.08±15.93** 61.29±7.57# 70.32±9.53# LDL-c (mg / dL) 12.08±4.32 32.15±5.76** 17.54±5.13## 19.63±5.14# HDL-c (mg / dL) 49.62±6.72 28.25±1.53** 36.41±2.67## 32.80±4.52# ALT(U / L) 9.12±1.67 12.67±2.36** 8.27±1.47# 10.72±2.75# AST(U / L) 10.47±2.85 16.47±2.67** 12.56±2.09## 14.20±2.55#

[0036] *P<0.05, **P<0.01, compared with the normal group at 5 weeks, #P<0.05, ##P<0.01, compared with the model group

[0037] After 5 weeks of feeding, the body weight and liver index of the model group rats were significantly higher than those of the normal group (P < 0.05, P < 0.01), and the plasma TG, TC, LDL-c, ALT and AST were also significantly higher than those of the normal group (P < 0.05 or P < 0.01), and HDL-c was lower than that of the normal group (P < 0.01). The plasma TG, TC and LDL-c of the rats in the Example 1 administration group and the positive drug administration group were lower (P < 0.05), and HDL-c was higher than that of the model group (P < 0.05). The effect of the Example 1 administration group was better than that of the positive drug administration; the results of transaminase detection showed that the plasma ALT of the rats in the Example 1 administration group and the positive drug administration group was lower than that of the model group, and the AST was lower than that of the model group. The effect of the Example 1 administration group was better than that of the positive drug.

[0038] Example 8: Clinical effect of the present invention on lowering blood lipids

[0039] Case selection: 60 patients (all with non-alcoholic fatty liver) were selected and randomly divided into a positive drug control group and a treatment group according to the random number table method, with 30 cases in each group. Western medicine diagnostic criteria: ① Meet the following three items of the "2012 Guidelines for the Diagnosis and Treatment of Non-alcoholic Fatty Liver Disease": a. Never drink or occasionally drink a small amount of alcohol (alcohol volume female <70g / week, male <140g / week). b. Exclude viral hepatitis and autoimmune liver disease; c. Imaging examination meets the pathological diagnostic criteria for fatty liver disease; ② Age 30 to 60 years old. TCM syndrome diagnostic criteria: According to the relevant standards of the "Guidelines for Clinical Research of New Chinese Medicines", the syndrome type is stasis and internal stagnation, original diabetes, Yin deficiency and fire, chronic persistent hepatitis, subcostal swelling, refusal to press in the middle, loss of appetite and fatigue, dark purple tongue with ecchymosis, thin white fur, and fine and astringent pulse.

[0040] Treatment method: The control group selected atorvastatin calcium tablets (Beijing Jialin Pharmaceutical Co., Ltd., national medicine standard H20093819, 20 mg / tablet) according to the condition of the disease. 4 weeks was a course of treatment, and the treatment lasted for 4 weeks. Example 1 Group took the granules prepared in Example 1, with a daily dosage of: Cuscuta 20g, Eucommia 14g, Millettia 10g, Morinda officinalis 10g, Lycium barbarum 25g, Ganoderma lucidum 15g, Polygonatum 25g, Panax notoginseng 15g, Dioscorea 20g, Salvia miltiorrhiza 15g, Trichosanthes 16g, Sterculia lychnophora 25g, Perilla seed 15g, Sargassum 10g, Perilla frutescens 20g, Citrus aurantium 15g, Cyperus rotundus 10g, Bupleurum 14g, Astragalus 25g, Pueraria lobata 20g, Ligusticum chuanxiong 20g, Peucedanum peucedanum 15g, Fritillaria cirrhosa 8g, Arisaema cinerea 10g, 4 weeks was a course of treatment, and the treatment lasted for 4 weeks.

[0041] Observation indicators: 10 mL of fasting blood was drawn from the two groups of patients in the morning before treatment and 4 weeks after treatment. The serum was centrifuged at 3000 rpm for 20 min. Liver function and blood lipids were measured using the hexokinase method on an automatic biochemical analyzer.

[0042] Experimental results: See Table 3.

[0043] Table 3 Comparison of liver function and blood lipids between the two groups before and after treatment (x±s, mmol / L)

[0044]

[0045] Note: Compared with the positive drug control group after 4 weeks of treatment, *P<0.05

[0046] There was no significant difference in liver function and blood lipid between the two groups before treatment (P>0.05). After 4 weeks of treatment, the alanine aminotransferase, aspartate aminotransferase, cholesterol and triglyceride of the treatment group were significantly lower than those of the control group (P<0.05), indicating that the present invention has the effect of lowering blood lipids, and the effect is better than that of the positive drug group.

[0047] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A Chinese medicine composition for treating fatty liver, characterized in that: The invention is prepared from the following raw materials in parts by weight: 15-25 parts of Cuscuta seeds, 12-16 parts of Eucommia bark, 8-12 parts of Millettia spatholobi, 5-15 parts of Morinda officinalis, 20-30 parts of Lycium barbarum, 10-20 parts of Ganoderma lucidum, 20-30 parts of Polygonatum sibiricum, 10-20 parts of Panax notoginseng, 15-25 parts of Dioscorea opposita, 10-20 parts of Salvia miltiorrhiza, 14-18 parts of Trichosanthes kirilowii, 20-30 parts of Sterculia lychnophora, 10-20 parts of Perilla seeds, 8-12 parts of Sargassum, 15-25 parts of Citrus aurantium, 10-20 parts of Tangerine peel, 8-12 parts of Cyperus rotundus, 12-16 parts of Bupleurum, 20-30 parts of Astragalus membranaceus, 10-20 parts of Pueraria root, 15-25 parts of Ligusticum chuanxiong, 10-20 parts of Peucedanum peucedanum, 6-10 parts of Fritillaria cirrhosa and 8-12 parts of Arisaema ciliata.

2. The Chinese medicine composition for treating fatty liver according to claim 1, characterized in that: The invention is prepared from the following raw materials in parts by weight: 20 parts of Cuscuta seeds, 14 parts of Eucommia ulmoides, 10 parts of Millettia spatholobi, 10 parts of Morinda officinalis, 25 parts of Lycium barbarum, 15 parts of Ganoderma lucidum, 25 parts of Polygonatum sibiricum, 15 parts of Panax notoginseng, 20 parts of Dioscorea opposita, 15 parts of Salvia miltiorrhiza, 16 parts of Trichosanthes kirilowii, 25 parts of Sterculia lychnophora, 15 parts of Perilla seeds, 10 parts of Sargassum, 20 parts of Citrus aurantium, 15 parts of Tangerine peel, 10 parts of Cyperus rotundus, 14 parts of Bupleurum chinense, 25 parts of Astragalus membranaceus, 20 parts of Pueraria root, 20 parts of Ligusticum chuanxiong, 15 parts of Peucedanum peucedanum, 8 parts of Fritillaria cirrhosa and 10 parts of Arisaema ciliata.

3. The Chinese medicine composition for treating fatty liver according to claim 1, characterized in that: The invention is prepared from the following raw materials in parts by weight: 15 parts of Cuscuta seeds, 16 parts of Eucommia bark, 8 parts of Millettia spatholobi, 15 parts of Morinda officinalis, 20 parts of Lycium barbarum, 20 parts of Ganoderma lucidum, 20 parts of Polygonatum sibiricum, 20 parts of Panax notoginseng, 15 parts of Dioscorea opposita, 20 parts of Salvia miltiorrhiza, 14 parts of Trichosanthes kirilowii, 30 parts of Sterculia lychnophora, 10 parts of Perilla seeds, 12 parts of Sargassum, 15 parts of Citrus aurantium, 20 parts of Tangerine peel, 8 parts of Cyperus rotundus, 16 parts of Bupleurum, 20 parts of Astragalus, 20 parts of Pueraria root, 15 parts of Ligusticum chuanxiong, 20 parts of Peucedanum peucedanum, 6 parts of Fritillaria cirrhosa and 12 parts of Arisaema ciliata.

4. The Chinese medicine composition for treating fatty liver according to claim 1, characterized in that: The invention is prepared from the following raw materials in parts by weight: 25 parts of Cuscuta seeds, 12 parts of Eucommia bark, 12 parts of Millettia spatholobi, 5 parts of Morinda officinalis, 30 parts of Lycium barbarum, 10 parts of Ganoderma lucidum, 30 parts of Polygonatum sibiricum, 10 parts of Panax notoginseng, 25 parts of Dioscorea opposita, 10 parts of Salvia miltiorrhiza, 18 parts of Trichosanthes kirilowii, 20 parts of Sterculia lychnophora, 20 parts of Perilla seeds, 8 parts of Sargassum, 25 parts of Citrus aurantium, 10 parts of Tangerine peel, 12 parts of Cyperus rotundus, 12 parts of Bupleurum chinense, 25 parts of Ligusticum chuanxiong, 10 parts of Peucedanum peucedanum, 30 parts of Astragalus membranaceus, 10 parts of Pueraria root, 10 parts of Fritillaria cirrhosa and 8 parts of Arisaema ciliata.

5. The Chinese medicine composition for treating fatty liver according to claim 1, characterized in that: Preparation method: After weighing the above medicinal materials according to the amount, crush them through a 20-mesh sieve, add water 12 times the weight of the medicinal materials to immerse the medicinal materials, soak for 3 hours, heat to boiling, decoct for 2 hours, take the decoction, decoct the residue 2-3 times according to the method, combine the decoctions, filter, evaporate and concentrate to a relative density of 1.2 at 25°C, add 1.5 times the amount of ethanol after cooling, mix well, let it stand overnight, take the supernatant, wash the precipitate with a small amount of 50% ethanol, combine the washing liquid and the filtrate, concentrate under reduced pressure to recover the ethanol, concentrate, cool and stand, filter, vacuum and low-temperature concentrate to a thick paste, the thick paste has a specific gravity of 1.33, spray dry, obtain the extract powder, add excipients, and make a preparation.

6. The Chinese medicine composition for treating fatty liver according to claim 5, characterized in that: The preparation is one of pills, tablets, capsules, granules, oral liquid and ointment.

7. The Chinese medicine composition for treating fatty liver according to claim 5, characterized in that: The concentration of the ethanol solution is 65-75%.

8. The Chinese medicine composition for treating fatty liver according to claim 5, characterized in that: The temperature of the reduced pressure concentration is 60-80°C.

9. Use of the traditional Chinese medicine composition for treating fatty liver as claimed in claim 1 in preparing a drug for treating fatty liver.

10. Use of the traditional Chinese medicine composition for treating fatty liver according to claim 9 in preparing a drug for treating fatty liver, characterized in that: Fatty liver belongs to the type of internal stagnation of blood stasis.

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