Preparation method of nano high-stability retinol

Abstract

The invention discloses a preparation method of nano high-stability retinol, which comprises the following steps: S1, preparing a water phase solution containing retinol, 1, 3-propylene glycol, sodium cocoamphoacetate, tocopheryl acetate, butylated hydroxytoluene, butylated hydroxyanisole and xanthan gum; s2, uniformly mixing retinol and natural carnauba wax according to a certain proportion, then heating to a molten state, and then quickly cooling to form a nano-sized wax wrapping structure, so as to form nano-particles with the particle size of about 220nm; s3, adding the nano-particles into the water phase solution until the nano-particles are uniformly distributed in the solution to form a faint yellow to yellow viscous suspension; and S4, filtering the mixed suspension at the temperature of not more than 40 DEG C, filling a finished product, and sealing and storing the finished product. And S5, testing the finished product to ensure that the quality of the product meets the standard. According to the invention, the long-term storage stability of the retinol is improved, and the infiltration capacity and safety of the retinol to the skin are also enhanced.

Description

Technical Field

[0001] The invention relates to the technical field of cosmetic raw material preparation, and in particular to a method for preparing nano high-stability retinol. Background Art

[0002] Retinol, as an important vitamin A derivative, is widely used in the cosmetics industry due to its excellent anti-aging effect on the skin. However, ordinary retinol molecules are highly unstable and are easily degraded by factors such as light, high temperature and oxidation, resulting in the loss of its active ingredients and affecting the effect of the final product. In addition, although traditional preparation methods such as microencapsulation and liposome encapsulation can improve the stability of retinol to a certain extent, there are still problems such as low bioavailability and high cost, which limit its wide application in cosmetic formulations. Summary of the invention

[0003] 1. Technical Problems Solved

[0004] The technical problems to be solved by the present invention are the various problems mentioned in the above background technology, and a method for preparing nano-retinol with high stability is provided.

[0005] 2. Technical Solution

[0006] In order to solve the above technical problems, the technical solution provided by the present invention is: a method for preparing nano high-stability retinol, comprising the following steps:

[0007] S1. Prepare an aqueous solution containing retinol (concentration of 7%, approximately equal to 17100-19800 IU / g), 1,3-propylene glycol, sodium cocoamphoacetate, tocopheryl acetate, butylated hydroxytoluene, butylated hydroxyanisole, and xanthan gum;

[0008] S2, using natural carnauba wax as a carrier material, mixing retinol and natural carnauba wax in a certain proportion, heating to a molten state, and then rapidly cooling to form a nano-sized wax-wrapped structure, forming nanoparticles with a particle size of about 220 nm;

[0009] S3, adding the nanoparticles prepared above to the aqueous solution prepared in step S1, and mixing thoroughly under stirring until the nanoparticles are evenly distributed in the solution to form a light yellow to yellow viscous suspension;

[0010] S4. Filter the mixed suspension at a temperature not exceeding 40°C, fill the finished product, and seal and preserve the finished product;

[0011] S5. The finished product in step S4 is subjected to physical and chemical property tests, including pH determination, particle size analysis and stability assessment, to ensure that the product quality meets the standards.

[0012] As an improvement, the ratio of the natural carnauba wax to retinol is between 1:1 and 3:1, with a preferred ratio of 2:1.

[0013] As an improvement, the specific temperature range of heating to a molten state is 60°C to 80°C, preferably 70°C.

[0014] As an improvement, the cooling rate in the rapid cooling process is 10°C to 20°C per minute, preferably 15°C per minute.

[0015] As an improvement, the average particle size of the nanoparticles is 200 nm to 250 nm, preferably 220 nm.

[0016] As an improvement, the pH value of the aqueous solution is adjusted to between 5.0 and 9.0, preferably to 6.5.

[0017] 3. Beneficial Effects

[0018] The advantages of the present invention compared with the prior art are:

[0019] The present invention provides a method for preparing nano high-stability retinol, by using natural carnauba wax as a carrier material, retinol and natural carnauba wax are uniformly mixed in a ratio of 1:1 to 3:1 (preferably 2:1), and then heated to a molten state of 60°C to 80°C (preferably 70°C), and subjected to high-pressure homogenization treatment to form nanoparticles with a particle size of about 200nm to 250nm (preferably 220nm). These nanoparticles are added to a pre-modulated aqueous phase solution containing auxiliary materials such as 1,3-propylene glycol, sodium cocoylamphoacetate, tocopherol acetate, butylated hydroxytoluene, butylated hydroxyanisole, xanthan gum, etc., and fully stirred and mixed at a temperature not exceeding 40°C, finally forming a light yellow to yellow viscous suspension, and the physical and chemical properties are tested to ensure product quality. This method significantly improves the stability of retinol under different storage conditions, especially maintaining a longer shelf life under light and high temperature environments; at the same time, due to the use of natural ingredients, the nanoparticles have good biocompatibility and permeability, which helps retinol to more effectively penetrate the stratum corneum and penetrate deep into the skin to exert its skin care effects, providing the cosmetics industry with more efficient and safe product options. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 The present invention is a flow chart of a method for preparing nano high-stability retinol. DETAILED DESCRIPTION

[0021] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments; based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0022] Embodiment 1

[0023] like Figure 1 As shown, a method for preparing nano high-stability retinol comprises the following steps:

[0024] S1. Prepare an aqueous solution containing retinol (concentration of 7%, approximately equal to 17100-19800 IU / g), 1,3-propylene glycol, sodium cocoamphoacetate, tocopheryl acetate, butylated hydroxytoluene, butylated hydroxyanisole, and xanthan gum, wherein the pH value of the aqueous solution is adjusted to between 5.0 and 9.0, preferably to 6.5;

[0025] S2, using natural carnauba wax as a carrier material, mixing retinol and natural carnauba wax in a certain ratio and then heating to a molten state, wherein the ratio of natural carnauba wax to retinol is between 1:1 and 3:1, preferably 2:1, and the specific temperature range of heating to a molten state is 60°C to 80°C, preferably 70°C, and then rapidly cooling to form a nano-sized waxy encapsulation structure, wherein the cooling rate during the rapid cooling process is reduced by 10°C to 20°C per minute, preferably 15°C per minute, to form nanoparticles with a particle size of about 220 nm, and the average particle size of the nanoparticles is 200nm to 250nm, preferably 220nm;

[0026] S3, adding the nanoparticles prepared above to the aqueous solution prepared in step S1, and mixing thoroughly under stirring until the nanoparticles are evenly distributed in the solution to form a light yellow to yellow viscous suspension;

[0027] S4. Filter the mixed suspension at a temperature not exceeding 40°C, fill the finished product, and seal and preserve the finished product;

[0028] S5. The finished product in step S4 is subjected to physical and chemical property tests, including pH determination, particle size analysis and stability assessment, to ensure that the product quality meets the standards.

[0029] In the specific implementation of the present invention: first, prepare an aqueous solution containing retinol (concentration of 7%, approximately equal to 17100-19800 IU / g), 1,3-propylene glycol, sodium cocoylamphoacetate, tocopheryl acetate, butylated hydroxytoluene, butylated hydroxyanisole, and xanthan gum. Next, take an appropriate amount of natural Brazilian palm wax as a carrier material, and mix it with retinol in a ratio of 1:1 to 3:1, preferably a ratio of 2:1. Heat the mixture to 60°C to 80°C, preferably 70°C, to completely melt it to form a uniform liquid mixture. Subsequently, the molten mixture is rapidly cooled, and the cooling rate is controlled to decrease by 10°C to 20°C per minute, preferably by 15°C per minute, to form a nano-sized waxy encapsulation structure, and finally obtain nanoparticles with a particle size of about 200nm to 250nm, preferably 220nm.

[0030] Next, the nanoparticles prepared above are slowly added to the pre-prepared aqueous solution and mixed thoroughly under continuous stirring until the nanoparticles are evenly distributed in the solution to form a light yellow to yellow viscous suspension. In order to ensure that the activity of retinol is not destroyed, the entire mixing process must be carried out at a low temperature of no more than 40°C. After mixing, the suspension is filtered to remove possible large particles, and then filled and sealed for storage to ensure the quality stability of the product during subsequent transportation and storage.

[0031] Finally, the finished product needs to undergo a series of physical and chemical property tests, including pH determination (adjusted to between 5.0 and 9.0, preferably pH 6.5), particle size analysis and stability assessment, to ensure that the product quality meets the established standards. The nano high-stability retinol suspension prepared through the above steps not only significantly improves the stability of retinol, but also enhances its biocompatibility and permeability. It is suitable for a variety of cosmetic formulations, especially for O / W and W / O emulsion systems, and can effectively improve the effect of skin care products.

[0032] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device.

[0033] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

[0034] The present invention and its embodiments are described above, and such description is not restrictive. The drawings show only one embodiment of the present invention, and the actual structure is not limited thereto. In short, if ordinary technicians in the field are inspired by it, without departing from the purpose of the invention, they can design a structure and embodiment similar to the technical solution without creativity, which should belong to the protection scope of the present invention.

Claims

1. A method for preparing nano high-stability retinol, characterized in that: The following steps are involved: S1. Prepare an aqueous solution containing retinol (concentration of 7%, approximately equal to 17100-19800 IU / g), 1,3-propylene glycol, sodium cocoamphoacetate, tocopheryl acetate, butylated hydroxytoluene, butylated hydroxyanisole, and xanthan gum; S2, using natural carnauba wax as a carrier material, mixing retinol and natural carnauba wax in a certain proportion, heating to a molten state, and then rapidly cooling to form a nano-sized wax-wrapped structure, forming nanoparticles with a particle size of about 220 nm; S3, adding the nanoparticles prepared above to the aqueous solution prepared in step S1, and mixing thoroughly under stirring until the nanoparticles are evenly distributed in the solution to form a light yellow to yellow viscous suspension; S4. Filter the mixed suspension at a temperature not exceeding 40°C, fill the finished product, and seal and preserve the finished product; S5. The finished product in step S4 is subjected to physical and chemical property tests, including pH determination, particle size analysis and stability assessment, to ensure that the product quality meets the standards.

2. The method for preparing nano high-stability retinol according to claim 1, characterized in that: The ratio of the natural carnauba wax to retinol is between 1:1 and 3:1, with a preferred ratio of 2:

1.

3. The method for preparing nano high-stability retinol according to claim 1, characterized in that: The specific temperature range of heating to a molten state is 60°C to 80°C, preferably 70°C.

4. The method for preparing nano high-stability retinol according to claim 1, characterized in that: The cooling rate in the rapid cooling process is 10° C. to 20° C. per minute, preferably 15° C. per minute.

5. The method for preparing nano high-stability retinol according to claim 1, characterized in that: The average particle size of the nanoparticles is 200 nm to 250 nm, preferably 220 nm.

6. The method for preparing nano high-stability retinol according to claim 1, characterized in that: The pH value of the aqueous phase solution is adjusted to between 5.0 and 9.0, preferably to 6.5.

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