Auxiliary equipment for treating malignant tumors by using hypertonic NaCl solution

Abstract

The invention relates to auxiliary equipment for treating malignant tumors by using a hypertonic NaCl solution, which is medical auxiliary equipment. According to experiments, 1 ml of 30% hypertonic NaCl solution can kill 1.5 cm < 3 > sarcoma 180 and 1.2 cm < 3 > rabbit liver tissues, and the guarantee coefficient dosages are increased by 20% and 15% respectively, that is, 1.2 ml and 1.15 ml of 30% hypertonic NaCl solution can kill any malignant tumor with the volume of 1.5 cm < 3 > and kill any normal tissue with the volume of 1 cm < 3 > and 2 cm < 3 > (except for leukemia). According to the volume of malignant tumors needing to be treated and the volume of surrounding tissues needing to be killed, the total amount of the required 30% hypertonic NaCl solution is calculated, and the 30% hypertonic NaCl solution is uniformly injected into the malignant tumors and the surrounding tissues, so that severe dehydration of cytoplasm, mitochondria and the like is caused by the strong hypertonic dehydration effect; and the tricarboxylic acid cycle generates energy to kill malignant cells and normal cells. Protein denaturation can be caused; salting-out cannot realize renaturation; the cure rate on sarcoma 180 is 86.7%, and toxic and side effects are avoided. The traditional Chinese medicine composition has the advantage of treating multiple metastatic cancers of liver, lung and brain.

Description

[0001] Technical field: Medical auxiliary equipment

[0002] 1. Technical Background A local treatment method that is superior to existing malignant tumors, can radically eliminate metastatic lesions and recurrent lesions, has minimal side effects, and can cure malignant tumors with less pain and less money. Inspired by the fact that cars in some African countries break down in the desert, dozens of people die of thirst due to hypertonic dehydration each time, and that the rainy season in some years in the savanna comes too late, and some wild animals die of thirst due to hypertonic dehydration, the malignant tumor cells are artificially dehydrated and cannot produce energy (ATP), and the dehydration-induced protein denaturation cannot be renatured to kill the malignant tumor cells, and the malignant tumors are treated by uniformly injecting hypertonic NaCl solution into the interstitial tissue of the malignant tumor and the interstitial tissue of the surrounding tissues, so that the cytoplasm and the line that can be affected by the injection are hypertonic dehydrated three-dimensionally, and most chemical reactions will not occur in places where there is no water. Enzymes and substrates (glucose, etc.) cannot react to produce energy (ATP) to kill malignant tumor cells, surrounding normal cells, and malignant tumor cells infiltrating therein. Therefore, the original energy (ATP) in the injection site injected with 30% hypertonic NaCl solution is exhausted, new energy (ATP) cannot be generated, and the energy (ATP) in the injection site = 0. Dehydration causes the inability to generate energy and denatures and precipitates the proteins of malignant tumor cells. When the mutagenic factor is relatively mild, it only causes the secondary structure of the protein molecule to lose its specific high-level spatial conformation, while the primary structure still exists and can create renaturation conditions in the laboratory; when the mutagenic effect is persistent and severe, the secondary structure of the protein molecule loses its specific high-level spatial conformation, and the primary structure (hydration layer, electron layer) is also destroyed, and the renaturation conditions cannot be created in the laboratory. In the tumor of malignant tumor patients, whether only the secondary structure of the protein molecule loses its specific high-level spatial conformation, or the secondary structure and primary structure of the protein molecule are destroyed at the same time, the renaturation conditions cannot be created. The cell nucleus cannot proliferate due to dehydration, and severe dehydration causes nuclear condensation and death; plasma dehydration in capillaries leads to blood stagnation and cuts off the supply of substances required for metabolism, which is one of the factors for the death of malignant tumor cells. Inspired by the salting out and coagulation of salted egg protein, which loses its biological activity and cannot hatch new life, and the salting out precipitation method (using slightly higher concentration of ammonium sulfate to salt out and precipitate protein) commonly used to extract protein, a strong neutral salt (30% hypertonic NaCl solution) was selected. The 30% hypertonic NaCl solution was injected into the interstitial tissue of malignant tumors and the interstitial tissue of surrounding normal tissues, which had a strong effect on protein molecules, completely destroyed them, and could not be renatured. When the 30% hypertonic NaCl solution absorbs water and is diluted to a certain extent during passive diffusion: when the concentration of neutral salt solutions such as Nacl is 0.15 mol / L (NaClM=56.44), it is easy to cause the protein molecules of malignant tumor cells to salt out and precipitate, and lose their biological activity. Renaturation conditions can be created for it in the laboratory, but they cannot be created in the malignant tumors and surrounding tissues of malignant tumor patients. Protein salting out precipitation and denaturation precipitation are not death, but damage, and low energy (ATP) is required to maintain this state. If it is to be renatured, it also needs low energy support.However, the energy (ATP) in the injection site of 30% hypertonic NaCl solution = 0, and the energy required for the refolding of protein salting-out precipitation (including denatured precipitation) is time-sensitive. Oxygen and energy (ATP) are not the same thing, but they are equally important. Oxygen is an indispensable substance for energy production. Brain hypoxia for 4-6 minutes can lead to brain-dead vegetative state; myocardial hypoxia for 20-30 minutes can cause infarction. After refolding, energy is still required to maintain its existence. Protein without energy (ATP) precipitation is equivalent to protein "death". All cells in the human body (except liver cells, which can also produce energy in the absence of oxygen) produce energy through aerobic metabolism. Generally speaking, there is no energy without oxygen, and human cells have limited tolerance to hypoxia, that is, lack of energy (ATP), and will die after a while. Negative oxygen balance in skeletal muscle during strenuous exercise can produce energy through anaerobic glycolysis, which is only a limited compensation unique to skeletal muscle. 30% hypertonic NaCl solution absorbs water and dilutes itself in passive diffusion. When its osmotic pressure is isotonic with that of body fluids, local tissues can generate energy. However, after a few hours, the tissues in the early hypoxic (energy-deficient) areas have died. Different tissues and organs of the human body have different tolerances to hypoxia (energy-deficient ATP), but the human body is an organic whole. If one organ dies due to hypoxia (energy-deficient ATP), the whole body will inevitably die. Cases of overall death caused by myocardial infarction and heart failure are not uncommon. The severe dehydration effect of 30% hypertonic NaCl solution causes protein molecules to denature, but 30% NaCl solution cannot cause protein denaturation through chemical reactions. The conditions for protein denaturation include strong acid, strong alkali, high temperature, dehydration, etc., and sodium chloride does not belong to such conditions. The sodium ions in sodium chloride are very stable and will hardly undergo any chemical reactions. They will not form coordination bonds with enzymes like other ions, so they cannot affect the structural morphology of enzymes, so they cannot denature proteins. However, they can reduce the solubility of proteins and cause protein salting out and precipitation, but this is not equivalent to protein denaturation. It is difficult to create renaturation conditions for salted out protein molecules in the laboratory, and it is even more difficult to create renaturation conditions for denatured protein molecules in the laboratory. In patients with malignant tumors, there are no conditions for renaturation of salted out protein molecules, let alone denatured protein molecules. Both protein molecules that have lost their biological activity will inevitably die in patients with malignant tumors. The work I did was not done in laboratory test tubes and flasks, but in ICR mouse sarcoma 180 and surrounding tissues (equivalent to the work done in malignant tumors and surrounding tissues of malignant tumor patients). There are no conditions for protein salting out and denaturation to restore biological activity here, nor are there conditions for creating renaturation conditions for protein molecules salting out and denaturation. The salted out precipitated and denatured precipitated proteins cannot be dissolved again to restore biological activity, and the protein molecules in the center of malignant tumor cells lose their activity and die. I weighed the pros and cons and selected 30% hypertonic NaCl solution from high-concentration neutral salt solutions to treat malignant tumors.As mentioned above, a research project on the treatment of mouse sarcoma 180 with hypertonic NaCl solution was designed, research funding was applied for, three related experimental studies were conducted, and three articles were summarized and published in the national core medical journal: Journal of the First Military Medical University (. Medical core journals - Baidu Encyclopedia:… 5. Journal of the First Military Medical University (renamed as: Journal of Southern Medical University) 6. PLA Medical Journal 7. Journal of Peking University. Medical Edition 8. Journal of Jilin University. Medical Edition 9. Journal of Sichuan University. Medical Edition 10. Journal of Chinese Academy of Medical Sciences 11. Chinese Journal of Modern Medicine 12. Journal of Fudan University. Medical Edition 13. Journal of Huazhong University of Science and Technology. Medical Edition 14. Journal of Sun Yat-sen University...). The article published in the Journal of the First Military Medical University is the document where the effective experimental data of the laboratory for this invention patent application is located.

[0003] Literature 1: Preliminary observation of hypertonic NaCl solution in the treatment of experimental tumors

[0004] Valid experimental data:

[0005] 1 Experimental design:

[0006] Animal selection:

[0007] 40 male ICR mice, 16 weeks old and weighing 15-18 g, were purchased from the Animal Institute of the First Military Medical University (those that did not meet the standard were not sold, and those that exceeded the standard were buried in the soil).

[0008] Animal breeding environment:

[0009] The mice were raised on the table in my office. They were fed with mouse feed with the national mouse feed formula, and water was placed in a 100ml glass bottle with a glass tube inserted into the plastic cap and inserted into the mouse cage. The mice were allowed to drink water at will. The raising and experiment period was November 1987, with an average temperature of 16℃ to 25℃, an average of 25℃ during the day and 16℃ at night; the average humidity was 77%. At night, an electric stove was placed in the ground indoors to keep the indoor temperature at 25℃.

[0010] Modeling:

[0011] Sarcoma 180 tumor vaccine comes from the animal room of the Tumor Research Institute of the Tumor Hospital of Zhongshan Medical College. It uses 180 sarcoma cells successfully cultured in the peritoneal cavity of mice with low-differentiated human breast cancer. 1x107-power 180 sarcoma cells were used in 1 ml of culture medium. 0.2 ml of culture medium containing sarcoma 180 cells was inoculated into the muscle of the outer right thigh of 40 mice. They were fed with normal food until the 6th day and randomly divided into a control group of 10 mice and a treatment group of 30 mice. NaCl 30g + distilled water to 100ml was prepared into a hypertonic NaCl solution. 0.2mg of naphazoline hydrochloride (clinical treatment dosage) was added to each 1ml of hypertonic NaCl solution as a vasoconstrictor. 0.4ml of the hypertonic NaCl solution was injected into 3-4 directions of the tumor in each of the 30 mice in the treatment group; no injection was given into the tumor of the control group.

[0012] The treatment group was divided into three groups: the 30 mice injected with hypertonic NaCl solution into the tumor were divided into three groups A, B, and C, with 10 mice in each group. The animals in the above groups were killed at different time periods and observed with the naked eye. The largest section of the tumor was taken, HE stained and made into sections, and the pathological changes were observed under an optical microscope. After the hypertonic NaCl solution was injected into the tumor, the A group was killed 2 hours, the B group was killed 6 hours, and the C group was killed 24 hours, and then the control group was killed.

[0013] Experimental results:

[0014] 1. Treatment group A: Tumor cells became dehydrated, smaller, and irregular. The intercellular spaces became wider and filled with fluid that had escaped from the tumor cell plasma, nucleus, organelles, and capillaries. The small blood vessels in the interstitium were congested, with focal hemorrhage.

[0015] 2. Treatment group B: The tumor cells were highly shrunken, the cytoplasm was concentrated, the nuclei were condensed, and there was flake necrosis; the interstitial small blood vessels were stagnant and congested (blood stagnation) and exudative bleeding.

[0016] 3. Treatment group C: diffuse coagulative necrosis of tumor cells occurred, with only a few tumor cell foci remaining. No ischemic changes such as turbid swelling, edema, and degeneration caused by naphazoline hydrochloride vasoconstrictor were observed in the above three groups.

[0017] The animals in the three treatment groups showed no abnormalities after injection of hypertonic NaCl solution and began to eat 20 minutes later.

[0018] 4. Control group: Most areas have the structural characteristics of sarcoma 180 solid tumor cells, with nucleoli visible. There are dot-like necrosis in the central part.

[0019] 5. According to the Delese principle, the percentage of tumor necrosis area in the control group and treatment group C in the largest section was measured by dot matrix method. T test showed that the necrosis area in treatment group C was much larger than that in the control group, P < 0.01, and the difference was very significant. According to the Delese principle, the dot matrix method is used to measure the area of ​​bone marrow hematopoiesis, which is more accurate than the area measured by the ruler on the microscope.

[0020] Experimental conclusion:

[0021] 30% hypertonic NaCl solution has a strong dehydrating effect. In the absence of water in the body, all chemical reactions will not occur, and enzymes and substrates cannot react to produce energy. Due to the main reason of not being able to produce energy, the cell pathological changes in the treatment group rapidly worsened, and the necrosis area caused by lack of energy was increased on the natural necrosis area. The total necrosis area was significantly larger than the natural necrosis area of ​​the control group (P < 0.01). The 30% hypertonic NaCl solution used had no toxic effect.

[0022] According to the information obtained, dehydration can cause severe and mild denaturation of proteins. Severe denaturation: The primary structure of the protein molecule loses its water layer, the electron layer becomes scarce, and the secondary structure loses its specific high-level spatial conformation, and it cannot renature and dies; mild denaturation only changes the aforementioned secondary structure without abnormal changes in the primary structure, and it can renature under creatin conditions in the laboratory, but cannot renature in the body and dies. When the water concentration of the hypertonic NaCl solution decreases to a certain level during passive diffusion, the protein salts out and precipitates, and it cannot renature in the body and dies. Denaturation and salting out are components of the factors that cause sarcoma cells to die.

[0023] Note: This manuscript discusses that dehydration can block energy formation and kill malignant tumor cells. It can also cause protein denaturation and salt precipitation in vivo, which cannot be renatured, which is also an important factor in killing tumor cells... The reviewer believes that it is not a new thing and deleted it. Deletion is equivalent to no deletion, and this effect still exists. The reason for the deletion cannot be accurately judged now. It is not ruled out that I did not write it clearly or expressed it inaccurately.

[0024] Literature 2: Light microscopic and transmission electron microscopic observation of sarcoma 180 treated with hypertonic NaCl solution.

[0025] Valid experimental data

[0026] Animal selection:

[0027] 40 male ICR mice, 16 weeks old and weighing 15-18 g, were purchased from the Animal Institute of the First Military Medical University (those that did not meet the standard were not sold, and those that exceeded the standard were buried in the soil).

[0028] Animal breeding environment:

[0029] The mice were raised on the table in my office. They were fed with mouse feed of the national mouse feed formula and water in a 100ml glass bottle with a glass tube inserted into the plastic cap and extended into the mouse cage. The mice were allowed to drink water at will. The raising and experiment time was April 1988. The average daily temperature in Sifen, Guangzhou was 19℃-26℃, with an average of 26℃ during the day; the humidity in Guangzhou in April ranged from 45% to 91%.

[0030] Modeling:

[0031] Sarcoma 180 tumor vaccine comes from the animal room of the Tumor Research Institute of the Tumor Hospital of Zhongshan Medical College. It uses 180 sarcoma cells successfully cultured in the peritoneal cavity of mice with low-differentiation human breast cancer. 2×106 180 sarcoma cells were inoculated into the muscles of the outer right thigh of 40 mice. They were fed with normal food until the end of the 6th day and randomly divided into a control group of 10 mice and a treatment group of 30 mice. NaCl 30g + distilled water to 100m was prepared into a hypertonic NaCl solution. Each 1ml of hypertonic NaCl solution contained 0.2mg of naphazoline hydrochloride (clinical treatment dosage) as a vasoconstrictor. The vasoconstrictor was injected into the tumor of each mouse in the treatment group at a dose of 0.4ml / mouse in 3-4 directions; no injection was given to the tumor of the control group. The treatment group was randomly divided into 3 groups, A, B, and C, with 10 mice in each group. The mice were killed 2h, 6h, and 24h after the injection of the hypertonic NaCl solution. The control group was killed on the seventh day after inoculation. After naked eye observation, the largest section of the tumor was taken and HE stained to make sections. According to Delgsse observation, the percentage of necrotic tissue in the largest section in the treatment group C and the control group was observed under an optical microscope. The tissue structure changes in the A, B, C and control groups were also observed. Electron microscopic sampling and conventional preparation were performed on the tumor edges of animals No. 1 and No. 2 in the treatment groups A, B, C and the control group, and ultrastructural changes were observed under a JEM1200EX transmission electron microscope.

[0032] Experimental results:

[0033] 1 The necrosis area in the control group accounted for 9.10% of the largest section; the necrosis area in the treatment group C accounted for 94.73% of the largest section, t-test P < 0.01, the difference between the two groups was very significant. There was no change in the tumor cells of the control group due to dehydration.

[0034] 2. As time went by, the blood circulation disorder in the three experimental groups worsened: from stasis congestion to intravascular coagulation; tumor cell dehydration worsened, tumor cell volume became smaller, shrunken, and developed into necrosis. The surrounding striated muscle cells degenerated.

[0035] 3. Changes under transmission electron microscopy: After the injection of hypertonic NaCl solution, blood circulation worsens with time, and there is a high degree of stasis and congestion. The cytoplasm of tumor cells is concentrated and the volume is reduced. The volume of organelles such as mitochondria is reduced, the electron density is increased, and degenerative vacuoles are seen. The nucleus shrinks and dissolves. By 24 hours, most tumor cells are necrotic and disintegrated.

[0036] Experimental conclusion:

[0037] 1. Light microscopic observations showed that 30% hypertonic NaCl solution has a strong dehydrating effect. There is no water in malignant tumor cells, and glucose cannot undergo anaerobic glycolysis in the cytoplasm to produce energy, causing sarcoma cell death.

[0038] 2. Transmission electron microscopy observations show that the hypertonic dehydration effect of 30% hypertonic NaCl solution. Dehydration can cause the cytoplasm of sarcoma to concentrate, the volume to decrease, the mitochondria to decrease, the electron density to increase, and vacuolar degeneration to occur. Most tumor cells will undergo necrosis and collapse within 24 hours. Without water, malignant tumor cells cannot anaerobic glycolysis of glucose to produce energy, which is the main cause of malignant tumor cell death. Mitochondria dehydrate and become smaller, the electron density increases, and vacuolar degeneration occurs. Even if glucose can be converted into a small amount of pyruvate, it cannot enter the mitochondria to produce energy through the tricarboxylic acid cycle due to the lack of free water. The tricarboxylic acid cycle stops running due to the lack of water. Therefore, dehydration can kill various normal cells of humans and mammals, such as normal cells around malignant tumors.

[0039] Note: The ability of dehydration to block energy production is positively correlated with the NaCl content in the hypertonic solution; dehydration causes protein denaturation in living cells such as malignant tumor cells, which cannot be renatured in the human body and kills living cells, which is positively correlated with the NaCl content in the hypertonic solution; neutral salt NaCl has the effect of salting out and precipitating proteins, which cannot be renatured in the human body and can kill living cells such as malignant tumor cells.

[0040] Literature 3: Observation on the therapeutic effect and immune status of compound hypertonic NaCl solution in treating S180 mice.

[0041] Valid experimental data:

[0042] 1 Experimental design:

[0043] Material selection:

[0044] 60 ICR mice were purchased from the Animal Institute of the First Military Medical University, aged 3 months, weighing 15-18 g (those that did not meet the weight standard were not sold, and those that exceeded the weight standard were buried in the soil). The mice were purchased in two batches.

[0045] For the first time, 30 male ICR mice were purchased to obtain sarcoma 180 tumor tissue and replicate the 180 sarcoma model. The sarcoma 180 tumor seedlings were from the animal room of the Tumor Research Institute of the Tumor Hospital of Zhongshan Medical College. The 180 sarcoma cells were successfully cultured in the peritoneal cavity of mice using low-differentiated human breast cancer. 1x106 180 sarcoma cells were inoculated into the muscles of the outer thighs of 30 mice. On the 6th day, the sarcoma tissue of each mouse was taken out and cut into 03cmx0.2cmx0.2cm180 sarcoma tissue blocks with the help of a mold. After cutting, they were immediately placed in the culture medium for use.

[0046] The second time, 30 male ICR mice were purchased to replicate the 180 sarcoma model with sarcoma 180 tumor tissue. The ceiling fan was turned on day and night in the room.

[0047] Animal breeding environment:

[0048] The mice were kept on the table in my office. It was May 1988. The average temperature in Guangzhou in May was 23℃-30℃, 30℃ during the day and 23℃ at night. The relative humidity was high, usually between 70% and 80%. The mice were fed with a mouse feed made from the national mouse feed formula, and a glass tube was inserted into the mouse cage with 100ml of water. The mice were allowed to drink water at will.

[0049] Modeling:

[0050] 1. Purchase 20 male and 10 female ICR mice from the Animal Research Institute. Make a small transverse cut on the outside of the thigh of the mouse, above the knee joint, insert ophthalmic forceps into the cut and separate the skin and muscle upwards. When reaching the upper thigh, use forceps to scrape left and right to destroy the fascia of the local muscle to cause tissue fluid extravasation (this point was forgotten to be recorded in the application).

[0051] 2. The sarcoma 180 tissue blocks soaked in culture medium were inoculated subcutaneously on the upper outer thigh of mice. The sarcoma 180 tissue blocks survived due to the plasma leaked from the ruptured blood vessels and the tissue fluid exuded from the ruptured muscle fascia, forming a sarcoma 180 solid tumor model that infiltrated the muscles downward and formed a hill-like protrusion outward.

[0052] 3. Based on the hillock-like protrusions of the sarcoma 180 solid tumor model, hypertonic NaCl solution is injected around and at the base of the malignant tumor to cure the malignant tumor. Otherwise, the mice are too small to undergo imaging examinations, and hypertonic NaCl solution cannot be accurately injected into the malignant tumor. Based on the hillock-like protrusions of the sarcoma 180 solid tumor model, hypertonic NaCl solution is injected around and at the base of the malignant tumor to cure the malignant tumor. Otherwise, the mice are too small to undergo imaging examinations, and hypertonic NaCl solution cannot be accurately injected into the malignant tumor. This is a modeling method with "three properties".

[0053] Grouping:

[0054] When the sarcoma tissue was cultured in the thigh muscle of mice for 6 days, 20 male and 10 female ICR mice were divided into two groups: the treatment group had 10 males and 5 females; the control group had 10 males and 5 females.

[0055] 2. Experimental methods:

[0056] Drugs and administration: The drug is a chemical combination drug: 30g NaCl + water containing 0.7g Novocaine to 100ml, prepared into a 30% hypertonic NaCl solution.

[0057] Administration method: The 30% hypertonic NaCl solution was injected into the periphery and base of the sarcoma 180 model in the treatment group. The control group was not given any treatment. The treatment efficacy was evaluated based on the condition of cure survival and recurrence death.

[0058] Drug safety evaluation: The administered animals did not show any discomfort until they were completely cured.

[0059] 3. Experimental results:

[0060] Treatment group: 10 were cured, 3 of them had local suppurative infection but no tumor cells were found, and died 25-30 days after inoculation. Among them, 94% died within 20 days. The total cure rate of this group was 86.7%. 2 died after relapse, accounting for 13.3%.

[0061] Control group: All died within 25 days after modeling. 94% died within 20 days. The difference between the groups in terms of survival and death was tested by t test.

[0062] P<0.01, very significant.

[0063] 4. Experimental conclusion: Hypertonic NaCl solution is very effective in treating sarcoma 180. In view of the commonalities between various human tissue cells, mammalian tissue cells and various malignant tumor cells stated in the application, the efficacy of hypertonic NaCl solution in treating human malignant tumors must also be very significant.

[0064] 2. Valid experimental data on immune status

[0065] Materials and Methods

[0066] Using the materials for observing effective experimental data on efficacy, i.e., the animal models of the treatment group and the control group, the changes in the amount of T lymphocytes and the activity of macrophage Fc receptors and their phagocytic function were measured on the 13th day after inoculation (the 7th day after treatment in the treatment group).

[0067] Experimental results: Changes in the number of T lymphocytes: the treatment group was nearly 49.67+ / -10.17, and the tumor-bearing control group was 22.07+ / -3.92, and the difference between the two groups was very significant, P < 0.01. The macrophage phagocytic function and Fc receptor activity were significantly different between the two groups (P < 0.01).

[0068] Experimental conclusion:

[0069] The mice in the treatment group with sarcoma 180 treated with hypertonic NaCl solution showed no changes in immunity; the mice in the control group (treated tumor model group) showed a significant decrease in immune function. Using hypertonic NaCl solution to treat malignant tumors will not reduce the patient's immunity.

[0070] 4. There are many popular methods for treating malignant tumors in the world today: ①. Immunotherapy: The efficacy varies from person to person. Although there are different degrees of relief and significant relief, only a few people are completely cured. Moreover, the incidence of side effects is high, serious, and can be fatal; ②. Targeted therapy: Drug resistance will occur. 2-3 types of alternating applications will have little effect in the end. It costs money in a long stream. The longer the survival time with the tumor is, the more difficult it is to cure. I feel sorry for my children after spending all my life savings; ③. Radiotherapy: Damage to normal tissues. Low-differentiated malignant tumors are not sensitive to radiotherapy. But radiotherapy is useful; Radiofrequency ablation: The trauma is obvious, it can cause transient arrhythmia, and it is easy to relapse after surgery; ④. Cryotherapy: Complications such as frostbite, shock, recurrence and metastasis may occur, and there are many disadvantages; ⑤. In recent years, ultrasound therapy (high-intensity focused ultrasound therapy, ultrasound thermal therapy, low-frequency and low-intensity ultrasound therapy...) has also emerged. I have received the feeling of efficacy, but I also feel that it is not satisfactory; ⑥. There are also stem cell therapy and T lymphocyte therapy: individual differences are obvious. Overall it is effective, but the cure rate is not satisfactory.

[0071] The mechanism of hypertonic NaCl solution in treating malignant tumors is clear: hypertonic dehydration blocks the formation of energy (ATP), hypertonic dehydration denatures tumor cell proteins and makes them unable to renature, makes tumor cell proteins salt out and lose biological activity and unable to renature, and makes capillaries in tumors hypertonic dehydrate, leading to blood stagnation, unable to transport nutrients such as glucose, and unable to transport acidic products. Hypertonic NaCl solution is effective in treating malignant tumors, simple and easy, with few side effects, and extremely cheap. It can be used for radical surgery or as a comprehensive treatment option. The advantage of this treatment is that malignant tumors have multiple metastatic lesions in the liver, lungs, and brain. For cases where there is no way to treat the aforementioned metastasis, treatment with hypertonic NaCl solution can save the lives of some patients, prolong the survival time of those who cannot be cured, and buy time for their treatment methods. This therapy uses hypertonic NaCl solution to hit the place where it dies; there is no need to evaluate whether it is dead or not wherever it is hit; if you want to kill a place, just hit it there. To hit it accurately requires experience and accumulation of certain experience. After my three articles were published, clinical research in this area was in full swing both at home and abroad.

[0072] Zhangqiao Research: Hypertonic NaCl solution for the treatment of malignant tumors. Related articles (86 articles in total) - Baidu.com

[0073] The Chinese Institute of Scientific and Technological Information promoted my first article "Preliminary Observations on the Treatment of Experimental Tumors with Hypertonic NaCl Solutions" and 50 similar papers on Baidu. This shows that the three papers I published as world-leading papers are very important, causing strong reactions at home and abroad, and related treatments are being carried out, some of which are in full swing.

[0074] 2. Invention content: 35 years ago, the combination of theory and practice laid the medical foundation for the treatment of malignant tumors with hypertonic NaCl solution.

[0075] What kind of medicine is hypertonic NaCl solution? It is a mixture of two chemical substances that do not react chemically. From a chemical point of view, it is a chemical mixture. Both substances have drug activity. When put together, they do not react with each other, but they can cure diseases, so it is called a chemical drug combination. For example, patients with dehydration can be supplemented with saline (0.9% NaCl solution), patients with insufficient blood volume can be supplemented with (10% NaCl solution), and (30% hypertonic NaCl solution can treat malignant tumors).

[0076] 1. Analysis found that there are many differences between various tissue cells of humans, various tissue cells of mammals, and various malignant tumor cells, but there are two points that are exactly the same:

[0077] (1) Various tissue cells of humans, various tissue cells of mammals, and various malignant tumor cells all need to metabolize to generate energy (ATP) in order to survive and proliferate. Metabolism can only be carried out in a place with water. If there is no water in the body, most chemical reactions will not occur. Enzymes and substrates will not react (it is now known that enzymes and water activate each other, accelerate hydrolysis reactions, and water participates in chemical reactions). Without the presence of water, the metabolism of the above three types of cells will stop, and they will inevitably die if they cannot produce energy (ATP).

[0078] (2) The main components of the three types of cell structures mentioned above are proteins. 30% hypertonic NaCl solution can dehydrate the three types of cells mentioned above and make them unable to produce energy (ATP), thus killing them. It is also a strong factor that denatures protein molecules (high temperature, vibration, high pressure, dehydration, stirring, ultraviolet irradiation...): Dehydration will denature protein molecules: in severe denaturation, the primary structure of the protein molecules loses the hydration layer and the electrons in the electron layer decrease; the secondary structure of the protein molecules loses a specific high-level spatial conformation. Severely denatured protein molecules cannot be renatured in the laboratory or in the patient's body and die. Mild protein denaturation: the secondary structure of the protein molecules loses a specific high-level conformation, but the primary structure is not destroyed, and has the basis for renaturation. However, a small amount of energy is needed to maintain this state of loss of function. When the hypertonic NaCl solution does not produce energy (ATP) in the injection site, the energy in the injection site = 0, and the mildly denatured protein will definitely die. Different proteins have different tolerance times to lack of energy, but the difference is not too large. When the hypertonic NaCl solution in the injection site absorbs water in passive diffusion and reduces its own concentration to a certain extent, that is, 0.15 mol / L (M=58, 44), the concentration of the NaCl solution at this time is the concentration at which protein molecules undergo salting out and precipitation, and it is also the concentration at which protein molecules of malignant tumor cells, surrounding normal cells, and malignant tumor cells infiltrated in the surrounding normal cells undergo salting out and precipitation. The protein molecules of the three major types of cells undergo salting out and precipitation, and they will definitely die if the conditions for renaturation and restoration of biological activity cannot be created for them. Hypertonic NaCl solution is a high concentration of neutral salt (it is used to treat malignant tumors; if it is to extract protein, ammonium sulfate solution is mostly used). NaCl solution is a neutral salt. When the neutral salt interacts with the protein molecule, the ions generated by the dissociation of the neutral salt compete for most of the free water, thereby destroying the hydration layer of the protein molecule, causing the protein solubility to decrease and precipitate. Since the neutral salt is a strong electrolyte with a strong dissociation effect, the dissociation of the neutral salt can inhibit the dissociation of the weak electrolyte of the protein, reduce the electrons in the protein electron layer, and make it easier to aggregate and precipitate. In the container in the laboratory, favorable conditions are created to make protein molecules salt out and precipitate, and then slightly denature and precipitate. Then, the conditions for restoring biological activity can be artificially met (using dialysis, ultrafiltration and other methods to remove excessive salt ions, maintain a slightly alkaline pH value (pH = 0.86-0.88), supply a small amount of energy, and maintain a low temperature of 4°C, which may make (2). The main components of the three major types of cell structures mentioned above are proteins. 30% hypertonic NaCl solution can dehydrate the above three types of cells and make them unable to produce energy (ATP), killing the three major types of cells. At the same time, it is still a strong factor that denatures protein molecules (high temperature, vibration, high pressure, dehydration, stirring, ultraviolet irradiation...). Dehydration will denature and precipitate protein molecules: slightly denature protein molecules, the secondary structure loses its specific high-level spatial conformation, but the primary structure is not destroyed, and has the basis for renaturation.However, a small amount of energy is needed to maintain this state of dysfunction. When the hypertonic NaCl solution injection site does not produce energy (ATP), the energy in the injection site = 0, and the denatured protein will definitely die. Severe protein denaturation, the primary and secondary structures of the protein molecules are all destroyed and cannot be renatured, and they die. When the hypertonic NaCl solution in the injection site absorbs water in passive diffusion to reduce its own concentration to a certain extent, that is, 0.15mol / L (M = 58, 44), the concentration of the NaCl solution at this time is the concentration at which protein molecules undergo salting out and precipitation, and it is also the concentration at which protein molecules of malignant tumor cells, surrounding normal cells, and malignant tumor cells infiltrated in the surrounding normal cells are salted out and precipitated. The protein molecules of the three major types of cells undergo salting out and precipitation, and they will definitely die if the renaturation conditions cannot be created to restore their biological activity. It is impossible to restore biological activity in the living human body. Proteins that are slightly denatured and precipitated due to dehydration and salting out precipitate urgently need to be renatured, and should not exceed 20-30 minutes. If you are anxious to remove too much neutral salt, you cannot place dialysis or ultrafiltration equipment in the malignant tumor to remove the excess salt. You can only wait for the passive diffusion to absorb water and dilute itself to achieve osmotic pressure balance with the surrounding tissues. But this waiting takes more than ten hours. Without energy supply, the precipitated protein will die long ago. Without a little energy (ATP) to maintain, without an alkaline environment (and the necrotic focus is acidic), the denatured and salted protein molecules will die. Among them, the stagnation of blood in the capillaries and the inability to transport metabolic acidic products play a certain role; ②. In the body, the protein molecules of any cell cannot or are difficult to create ideal renaturation conditions after salting out and precipitation, such as alkaline environment (pH = 8.6-8.8) and maintaining a low temperature of 4°C. The normal body temperature of the human body is around 37°C, and there is no such low temperature in the ward or operating room. Even if the salting out of the protein molecules is not severely damaged, it cannot be renatured and can only die. Doctors are treating malignant tumors. The salting out and denaturation of protein molecules cannot be naturally renatured, so they will not create conditions for restoring biological activity, so that the protein molecules of malignant tumor cells lose their activity and come alive again. Such conditions are also difficult to create; ③. Since the treatment of malignant tumors in patients is not carried out at ultra-low temperatures, energy is always required from living cells to protein molecules in cells. In the absence of energy, there is an urgent time limit from precipitation (loss of biological activity) to recovery of biological activity, and it cannot last too long (as stated above). "Life is the form of protein existence". Energy (ATP) is the material basis for the existence and activity of life. Without energy (ATP), life will no longer exist. Hypertonic NaCl solution treats malignant tumors by blocking the two key points of living cells, including malignant tumor cells, from producing energy and destroying cell proteins through hypertonic dehydration. No other substances need to be added. Adding other substances is of little significance or has side effects.

[0079] 2. Inject 30% hypertonic NaCl solution into the interstitial tissue of malignant tumors and the surrounding normal tissue interstitial tissue, forming a significant osmotic pressure gradient with the area around the injection site. It absorbs water in the process of local and passive diffusion, causing hypertonic dehydration of malignant tumor cells. In the absence of water, enzymes and substrates (here refers to glucose) cannot react and energy (ATP) cannot be generated. All living cells that require water for metabolism, including malignant tumor cells, will inevitably die.

[0080] 2.1. Hypertonic NaCl solution causes severe dehydration of cytoplasm and mitochondria of organelles (cell membrane, organelle membrane, nuclear membrane are biological membranes with semipermeable membrane characteristics, and capillary wall has semipermeable membrane characteristics). In the absence of water, glucose cannot be converted into pyruvate by anaerobic glycolysis under the action of enzymes. Without energy support, transport proteins cannot deliver pyruvate into mitochondria. Without the presence of water, pyruvate entering mitochondria cannot be converted into acetyl CoA (coenzyme A) by the action of three enzymes such as pyruvate kinase. Without water, acetyl CoA (coenzyme A) cannot react with oxaloacetate to convert into citric acid and enter the tricarboxylic acid cycle to generate energy (ATP). Malignant tumor cells produce energy (ATP) mainly by anaerobic glycolysis of glucose, with a total of 10 steps. Without water in each step, enzymes cannot convert glucose into energy (ATP). Without energy, the above three types of cells, including malignant tumor cells, will die.

[0081] 2.2. Hypertonic NaCl solution dehydrates the plasma in the capillaries (the walls of small blood vessels have the characteristics of semipermeable membranes), causing stasis and congestion (blood stagnation), cutting off the supply of substances required for metabolism, mainly the supply of glucose required for metabolism, and failing to produce energy (ATP) or transport the acidic products produced by metabolism. The above three types of cells, including malignant tumor cells, will inevitably die. The acidic substances produced by cell metabolism cannot be discharged due to blood flow obstruction, which will lead to acidosis.

[0082] 3. The success of using hypertonic NaCl solution to treat malignant tumors is due to the physical phenomenon of passive diffusion that is not dependent on human will: in passive diffusion, water is absorbed and the body is diluted to achieve osmotic pressure balance. Injecting hypertonic NaCl solution into rabbit liver tissue caused liver tissue necrosis. After 72 hours, the osmotic pressure of the necrotic focus had already reached equilibrium with the osmotic pressure of the body. A small amount of granulation tissue (capillaries and fibroblasts) proliferated around the necrotic focus, and local organization began, and macrophages engulfed the necrotic tissue. If the osmotic pressure is not balanced with the osmotic pressure of the surrounding tissue, the tissue will continue to be damaged and absorptive changes will not occur.

[0083] 4. Example of using hypertonic NaCl solution to treat advanced metastatic malignant tumors:

[0084] Treatment of advanced metastatic malignant tumors with 30% hypertonic NaCl solution: The treatment of advanced metastatic malignant tumors with 30% hypertonic NaCl solution is the strength of this treatment method: such as intrahepatic metastatic cancer, recurrent liver cancer; treatment of peripheral lung cancer and intrapulmonary metastatic malignant tumors; treatment of brain gliomas and intracranial metastatic cancer. Isolated malignant tumors and metastatic cancers in any part that do not infiltrate larger blood vessels and nerves. Treatment of malignant tumors with a diameter of less than 1cm requires killing 0.5cm of surrounding normal tissue. Treatment of malignant tumors with a diameter of >1cm requires killing 1cm of surrounding normal tissue. Longer needles for injection (needle stem diameter 0.75mm, 0.55mm, or needles with a thinner stem).

[0085] 4.1. Injection treatment of recurrent liver cancer and multiple metastatic cancers in the liver under the guidance of color ultrasound: ①. Injection treatment of recurrent liver cancer and multiple metastatic cancers in the liver under the guidance of color ultrasound: First, a three-dimensional image should be obtained under CT, and a three-dimensional printed image should be obtained on this basis. Design a treatment plan based on the image. Make a careful treatment plan before surgery. Indwelling catheterization, general anesthesia, and injection treatment with an extended but not thickened injection needle under the guidance of color ultrasound. Tumors that infiltrate larger blood vessels can only kill part of the tumor tissue, and comprehensive treatment is used. ②. Treatment of intrahepatic malignant tumors with 30% hypertonic NaCl solution Notes: This treatment is not suitable for patients with liver failure; liver failure should not occur after treatment; pay attention to the treatment and care of other diseases, encourage patients to drink more water, and observe for 3-4 days after surgery for smaller diseases. The necrotic lesions killed are larger, and they should be observed for one week before discharge. All patients who have been treated will return to the hospital for reexamination after three to four weeks. If the cancer cells that have not been killed form small nodules, they will be injected again.

[0086] 4.2. Treatment of peripheral lung cancer and metastatic malignant tumors in the lungs: ①. Before the operation, a detailed treatment plan, possible problems and countermeasures should be formulated for the malignant tumor lesions in the lungs based on the imaging report (including three-dimensional images and three-dimensional printed images). The operation is performed under general anesthesia. Indwelling catheterization, under the guidance of a digital X-ray machine (portable) under general anesthesia, injection treatment is performed with an extended but not thickened injection needle. It infiltrates larger blood vessels and is difficult to cure. It can only partially kill the malignant tumor and alleviate the condition. Further treatment is used for radiotherapy and chemotherapy. Children and young people are prone to osteosarcoma and multiple metastases in the lungs. Multiple 0.1cm-0.3cm small nodules appear in both lungs (almost all osteosarcoma patients died before). The early metastasis is the best time to treat with 30% hypertonic NaCl solution. 0.2ml-0.5ml is injected into each metastatic focus. Isolated small nodules at the hilum of the lung can also be injected for treatment. Once they grow and infiltrate blood vessels, it will be troublesome. ②. Precautions for using 30% hypertonic NaCl solution to treat lung malignancies: When using 30% hypertonic NaCl solution to treat lung malignancies, it is necessary to ensure that one lung still has function; strictly prevent high-pressure pneumothorax, and take precautionary measures when necessary; when injecting 30% hypertonic NaCl solution to treat peripheral lung cancer and metastatic sarcoma, the healed needle holes may rupture again due to strong coughing and cause high-pressure pneumothorax. Pay attention to the treatment and care of other diseases, encourage patients to drink more water, observe patients without cough or mild cough for 3 days, and observe patients with severe cough for one week. Appropriate intravenous analgesics; oral sedatives / antitussives; the use of hypertonic NaCl solution injection to treat the infiltrating tumor tissue around the lung malignant tumor lesion should be "meticulous": the hypertonic NaCl solution should be injected into the edge of the nearby tumor substance, and the infiltrating malignant tumor tissue should be killed by passive diffusion; if there is a protruding tumor tissue, the injection should be into the tumor tissue instead of the outer lung tissue. In this way, the hypertonic NaCl solution diffuses along the alveolar pores to kill more lung tissue and less malignant tumors. Hypertonic NaCl solution should not be injected into the small bronchi to prevent the hypertonic NaCl solution from entering the bronchi. When the patient coughs strongly after waking up from anesthesia, the hypertonic NaCl solution will enter other lung lobes and cause lung tissue damage; pay attention to the treatment and care of the original disease; be discharged from the hospital one week after surgery and return to the hospital for a follow-up examination three to four weeks later.

[0087] 4.3. Treatment of brain glioma and intracranial metastasis with 30% hypertonic NaCl solution: ①. Treatment of brain glioma and intracranial metastasis with 30% hypertonic NaCl solution: Preoperative CT accurate positioning, detailed treatment plan, and selection of appropriate intracranial entry position. General anesthesia, indwelling catheterization; 1 cm small incision in the scalp, 0.2-0.3 cm small hole drilled in the skull, and injection treatment was performed with an extended but not thickened injection needle.

[0088] ②. Use 30% hypertonic NaCl solution to treat brain glioma and intracranial metastatic cancer. Note: Malignant tumors should be kept away from the internal capsule area (1.5 cm); prevent excessive intracranial pressure and foramen magnum herniation.

[0089] 5. As an auxiliary device for the treatment of malignant tumors with hypertonic NaCl solution. Specific implementation plan

[0090] 1. Through experiments, it was found that 1 ml of 30% hypertonic NaCl solution can kill the volume of malignant tumor tissue and normal tissue: I used 30g of medical NaCl + distilled water to 100ml to prepare a hypertonic NaCl solution. 1x106 sarcoma 180 cells (the tumor seedlings came from the Tumor Research Institute of Zhongshan Medical College, and were successfully cultured in the peritoneal cavity of ICR mice using poorly differentiated human breast cancer cells) were inoculated into the right thigh muscles of 12 ICR mice. Four mice were randomly killed after 96 hours and no natural necrosis was found. At 100 hours, 0.4 ml of 30% hypertonic NaCl solution was injected into the center of the inoculated tumor, and the mice were killed after another 24 hours. The radii of the necrotic focus in three perpendicular directions were measured: a, b, c (the measurement error was about + / -0.2 m squared). - 0.3mm). The formula: V = 4 / 3x[3.14x(axbx) can be used for calculation, and it is calculated that 1ml of 30% hypertonic NaCl solution can kill 1.5cm3 of sarcoma 180 tissue (not written in the published article). Under general anesthesia and laparotomy, 0.6ml of 30% hypertonic NaCl solution was injected into the thickest part of the four liver lobes of two rabbits, and the abdominal wall was sutured. One animal was killed at 12 hours and 72 hours of over-anesthesia. The three vertical radii of each of the eight necrotic foci were measured, and the above formula was used to calculate that 1ml of 30% hypertonic NaCl solution can kill 1.2cm3 of rabbit liver tissue. Although only 1ml of 30% hypertonic NaCl solution can kill 1.5cm3 of sarcoma 180 tissue from 8 ICR mice and 1ml of 30% hypertonic NaCl solution can kill 1.2cm3 of liver tissue from 8 necrotic foci of rabbit liver tissue, due to the increase of 20% in each guarantee.

[0091] The coefficient dosage and the 15% guarantee coefficient dosage. Therefore, the number of experimental animals observed and the number of liver tissue necrosis foci observed are not small, that is, there will be no negative impact.

[0092] 2. The laboratory obtained that 1ml 30% hypertonic NaCl solution can kill 1.5cm3 of sarcoma 180 tissue, and the amount of the guarantee factor can represent the volume of any malignant tumor tissue killed; the volume of 1.2cm3 of rabbit liver tissue that can be killed can represent the volume of normal tissue killed: the sarcoma 180 cells I used were cultured in the peritoneal cavity of ICR mice with low-differentiation breast cancer cells. When inoculated into the muscle to form a solid tumor, its unit volume water content is similar to that of human breast cancer. If the guarantee factor is not added, the volume of any normal tissue killed by 1ml 30% hypertonic NaCl solution and the volume of any malignant tumor tissue killed are not representative. Therefore, the above strategy was adopted. These two data plus the guarantee factor can basically be used as the volume of various malignant tumors killed by 1ml 30% hypertonic NaCl solution in the human body and the volume of various surrounding normal tissues killed. The size of the volume of normal tissue killed by 1ml 30% hypertonic NaCl solution and the size of the volume of malignant tumors killed are negatively correlated with the amount of water per unit volume of the injected tissue. [High school biology required], Chapter 2, Section 2 records (same as medical biology, and concise). The water content in humans and most mammals is relatively close. The water content in mammals accounts for 65% of body weight; the water content in adult males accounts for 65%-60% of body weight; the water content in adult females accounts for 52%-58% of body weight; the water content in the elderly accounts for 55% of body weight (blood tissue contains more water, accounting for 88% of body weight, and bone tissue contains less water, accounting for 22% of body weight. Malignant tumors of these two tissues are not suitable for treatment with this method). Therefore, 1ml of 30% hypertonic NaCl solution can kill the same volume of normal male tissue and mammalian tissue, both of which are about 1.2cm3). The volume of normal tissue that kills adult females and the elderly will be greater than 1.2cm3. Although the water content per unit volume of different malignant tumor tissues and the water content per unit volume of different normal human tissues are different, the difference is not large. Especially in the clinical application of malignant tumor treatment, after increasing the dosage of 30% hypertonic NaCl solution for killing normal tissue by 15% and the dosage of 30% hypertonic NaCl solution for killing malignant tumor tissue by 20%, 1ml of 30% hypertonic NaCl solution can represent the volume of normal tissue killed is 1.2cm3, and 1ml of 30% hypertonic NaCl solution can represent the volume of malignant tumor killed is 1.5cn3 (the actual volume of both killed will be larger than expected, which can prevent the residual malignant tumor tissue and help prevent recurrence).

[0093] 3. Calculation of clinical treatment dosage: Take the volume of the malignant tumor to be treated and the volume of the surrounding normal tissue to be killed as the numerator, and use the known volume of the malignant tumor and the volume of the normal tissue that can be killed by 1ml of 30% hypertonic NaCl solution as the denominator to obtain the dosage of 30% hypertonic NaCl solution to kill a certain malignant tumor tissue, and increase the dosage of the guarantee factor by 20% (which needs to be gradually adjusted in actual construction), and the dosage of 30% hypertonic NaCl solution to kill some normal tissues, and increase the dosage of the guarantee factor by 15% (the dosage of the guarantee factor is temporarily determined and needs to be gradually revised in future actual construction). The sum of the above 4 dosages of 30% hypertonic NaCl solution is called the clinical treatment dosage. According to the size of the malignant tumor, 1-point injection method, 6-point injection method, 8-point injection method, and multiple-point injection method can be used.

[0094] The following is an introduction to the injection therapy method from 1 point to multiple points: ①. 1 point injection method: When the diameter of the malignant tumor is equal to or less than 2cm, the clinical treatment amount of 30% hypertonic NaCl solution is evenly injected into the malignant tumor and the surrounding 0.5cm range at multiple points; ②. 6 point injection method: When the diameter of the malignant tumor is greater than 2cm / =3cm, the clinical treatment amount of 30% hypertonic NaCl solution is divided into 6 equal parts with 1 / 3 of the outer 6 vertical radii as the injection center, and evenly injected into the normal tissue including the 1cm outside the malignant tumor; ③. When the diameter of the malignant tumor is greater than 3ccm / =4cm, use the 8 point injection method: Like cutting a watermelon, divide the malignant tumor and the surrounding 1cm into eight pieces. Divide the clinical amount of 30% hypertonic NaCl solution into 8 equal parts, and evenly inject it at 0.5cm from the edge of the tumor and the surrounding tissue; ④. Multi-point injection: When the diameter of the malignant tumor is greater than 4ccm / =5cm, use the multi-point injection method. Consider the malignant tumor as a nearly circular shape, and divide the 30% hypertonic NaCl solution used in clinical treatment into 23 equal parts, with the injection depth being 0.5 cm from the edge of the tumor and within 1 cm around it. This is equivalent to 7 equal parts on the equator; 5 equal parts on each of the two 45-degree lines; and 3 equal parts on each of the two polar circles. The above is for reference only, because malignant tumors are not round, and flexibility must be maintained to reasonably inject 30% hypertonic NaCl solution according to the specific shape of the malignant tumor. Any injection method that can kill all malignant tumor cells is a good method.

[0095] 4. The role of dosage in increasing the security factor: ①. The injection point may not be accurate. When the injection is not accurate enough, the malignant tumor tissue that has not been killed may remain between the malignant tumor necrosis foci formed by the two injection points, becoming a stable risk of recurrence; ②. The volume of malignant tumor tissue killed by a certain amount of 30% hypertonic NaCl solution (including the volume of normal tissue killed) is negatively correlated with the amount of water content per unit volume. The proliferation rate of malignant tumor cells is much faster than that of capillary endothelial cells. Although malignant tumor cells have more water content than normal cells due to vigorous metabolism, the water content per unit volume is low due to too few blood vessels. Animal experiments have obtained that 1ml of 30% hypertonic NaCl solution kills 1.5cm3 of sarcoma 180 tissues and can kill 1.2cm3 of rabbit liver tissue. The water content per unit volume is different between different types of malignant tumors, between the edge and center of the same malignant tumor tissue, and when the degree of differentiation of the same type of malignant tumor tissue is different, the water content per unit volume is also different. The water content per unit volume of different types of normal tissues around malignant tumor tissue is also different. Since the water content per unit volume of malignant tumor tissue and normal tissue surrounding the malignant tumor tissue is different, it is impossible to find 1 ml of 30% hypertonic NaCl solution that can kill the malignant tumor tissue and the normal tissue as a representative volume. That is, there are similar sizes and certain differences. The method of increasing the dosage of the protection factor can balance these differences, so that the necrotic foci formed will increase and fuse, and only the amount of necrotic foci fusion will be different, so that the malignant tumor tissue that has not been killed will not be missed, and the malignant tumor cells that have not been killed will not be missed from infiltrating the surrounding tissues to become a hidden danger of recurrence.

[0096] 5. The dosage of 30% hypertonic NaCl solution for each treatment: The World Health Organization once believed that the daily salt intake of the general population is 6g-8g per person. 3 days of NaCl intake can be used to prepare 60ml-80ml of 30% hypertonic NaCl solution. The hypertonic NaCl solution is injected into the local part of the body and is absorbed slowly. The renal artery is emitted from the aorta, and the amount of blood entering the renal artery is 1 / 3 of the cardiac output. It has a strong ability to regulate the balance of water and electrolytes in the body. In addition, it is safer to let the patient drink more water. It does not cause a transient increase in blood sodium. At this time, the increase in ghrelin in the blood is beneficial to promote the patient's appetite. Long-term high-salt diet will cause hypertension, but one or two or three times of high blood sodium will not cause hypertension.

[0097] IV. Auxiliary equipment for the treatment of malignant tumors with hypertonic NaCl solution

[0098] 1. Technical solution for producing non-intelligent machinery: Non-intelligent machinery can be divided into: base (including bed surface and bracket), mechanical body, DC servo motor supporting reversal signal, servo motor control console, injection unit, and DC power supply.

[0099] (1). Base: The base is designed as an operating bed; it consists of a bed surface and a bracket. ①. A stainless steel wire mesh frame with a length of 180 cm and a width of 60 cm, with a rectangular frame made of 14 cm thick and 12 cm wide rigid metal welded on the four sides; ②. A trapezoidal groove with a width of 6 cm, a bottom width of 8 cm, and a depth of 10 cm is made in the upper back 1 / 2 of both sides of the frame; ③. A bridge steel plate: 0.6 cm thick, 84 cm wide, and 320 cm long, with 0.1 cm thick stainless steel plates wrapped around the two sides and four edges. Flatten the 100cm long part of the steel plate; then press the two ends of the 100cm plate downward at an angle of 125 degrees, and then fold the two lower 40cm towards the center of the bed into "feet" parallel to the ground, and stick the "sole" with anti-slip material with special glue; ④. Place the bed frame on the bracket, align the two sides of the middle part of the bed frame with the two sides of the bracket, and use multiple smaller screws to fix the lower part of the bed frame on both sides from the lower part of the bracket to form a complete operating bed; ⑤. Install an aluminum alloy metal plate on the upper side of the bed facing the patient's shoulders on both sides, forming a 70-degree angle with the outer side of the bed. The support plate supports the patient's upper limbs during surgery, and uses Velcro straps to tie the upper part of the upper limbs, elbows, and wrists (knees and hips also need to be tied to the bed with Velcro straps. The bed is covered with an artificial sponge pad wrapped in anti-pollution material.

[0100] (2) Mechanical body: ①. Aluminum alloy plate is used to make a 0.4cm thick aluminum alloy box (equivalent to the body of the machine) with a height of 30cm, a width of 20cm, and a thickness of 16cm. The bottom of the box is 20cm away from the skin of the abdomen and chest. ②. Corresponding 3m x 6cm horizontal openings are made on the left and right walls of the upper 1 / 3 of the box, and an aluminum alloy arc body (equivalent to the horizontal bridge) of about 180cm long, 3cm thick, and 6cm wide is inserted into the opening. The aluminum alloy box can move left and right along the aluminum alloy bridge. The bottom of the box is 20cm away from the skin of the chest. A DC servo motor (DC servo motor + reducer) is installed between the aluminum alloy box and the arc bridge; the servo motor driver used in this non-intelligent machine must support reverse input signals. The two ends of the bridge are welded to the upper bottom of a 12cm long trapezoidal body, which is inserted into the trapezoidal groove of the back 1 / 2 of both sides of the bed, and can slide from the back to the upper side of the navel. A DC servo motor (DC servo motor + reducer) is installed on each trapezoidal body; ③. A circular hole with a diameter of 10cm is made 3cm near the bottom of the aluminum alloy box. 8cm away from the left wall and in the corresponding direction of the front and rear walls, and a 0.4cm thick aluminum alloy round tube (equivalent to the boom) is inserted through it. There are gear grooves on the front and rear of the left side of the boom, and a DC servo motor (DC servo motor + reducer) is installed on the inner wall of the aluminum alloy box corresponding to the gear groove. Its gear engages and links with the gear groove on the side of the boom, so that the boom can only move forward and backward; ④. The far end of the boom and the forearm

[0101] The proximal end is connected with a left-right rotating joint. There is a DC servo motor (DC servo motor + reducer) at the joint; ⑤. The distal end of the forearm is connected to the palm through the wrist joint. The distal part of the wrist joint uses a 9.5cm diameter and 6cm long aluminum alloy cylinder. The 3cm at one end is fixed with a special glue and the 2cm long cylinder at the distal end of the forearm. A 0.4cm wide gap is made at the 3cm of the outer distal end. Another section of aluminum alloy square column is used, which is 8cm long and 5cm wide and thick. A 0.4cm thick and 3cm long tenon is made at the proximal end. The two corners are polished into a circle and inserted into the proximal gap. A through circular hole is drilled from the appropriate position on the side, and a proper screw is passed through. The opposite side is fixed with a nut. A wrist joint that can swing up and down is formed. At the distance of 1cm from the front end of the palm, a 2cm x 2cm square hole is made perpendicular to the ground, and a 20cm square aluminum alloy bar is inserted into the hole. A DC servo motor (DC servo motor + reducer) is installed on the right side of the wrist. Tooth-like protrusions with equal distances are made from top to bottom on the right side of the aluminum alloy strip, and upper and lower long openings are made on the corresponding side square hole wall: the opening is 0.4cm wide and 4cm long. Through this opening, the gear installed on the front shaft of the DC servo motor can be embedded with the tooth-like protrusion on the inside, and there is a cover-like protective device; a groove with a length of 2cm, a width of 0.2cm, and a depth of 1.5cm is made on the aluminum alloy square strip 0.5cm above the front lower end, and the groove is perpendicular to the "finger" inserted with the injection needle. A nut hole is drilled on the side wall, and a screw with a handle at one end is screwed into the nut to fix the finger and prevent it from moving; ⑥. The "finger" is made of stainless steel plate: 6cm long, 2cm wide, and 0.2cm thick. Drill the needle stem (outer diameter of 0.75mm, 0.55mm or thinner) for the injection needle on the 0.2cm thick metal wall of the three needle holding fingers, drill the nut hole at the far end, screw the screw into the nut to fix the injection needle stem. Put a hard plastic tube on the upper end of the injection needle stem, and the far end of the tube is connected to the 2cm needle stem with the 12G needle plug on the nipple of the syringe tube filled with hypertonic NaCl solution. The doctor is responsible for the injection in the radiation protection room; ⑦. A small servo motor + reducer is installed horizontally on the upper part of the forearm at the far end of the wrist. Two U-shaped groove winding shafts are installed on the front rotating shaft of the servo motor. The two are close together. When winding the leather rope on the shaft, one is wound clockwise and the other is wound counterclockwise. A 5cm long and 0.4cm diameter steel column is vertically welded on the left side of the wrist (the middle part of the steel column is welded on the left side of the wrist). There are round holes at both ends of the steel column, and the leather ropes wrapped around the two U-shaped shafts on the servo are fixed to the two ends of the cylinder perpendicular to the wrist. The wrist can be controlled to lift up and bend downward, so the injection needle can be controlled to form an angle forward and backward for injection.

[0102] (3) Manual control console: A control console is customized from a company. There is a control system for each DC servo motor in the control console. The control console is placed on the front table in the radiation protection room. The lines are connected by professionals. Carefully debug before use. Power supply: The AC power is converted into DC power through four processes: rectification, filtering, voltage regulation and current limiting. Each DC servo motor is connected through the control system (the servo driver must support the reverse signal). There is a reverse signal twist on the control lever. When the control lever is pushed forward, the servo motor rotates counterclockwise. When the lever is pulled back, a reverse signal is sent to the driver, and the servo motor rotates clockwise. The user should remember the role of each servo and be proficient in kneading. The wires are concentrated in the control console, gathered into a bundle behind the wall of the control console, and then through the lead pipe (faucet-like lead pipe) on the wall of the radiation protection room to the outside, put into a hard plastic pipe and pulled to the side of the machine, and the wires are connected to the corresponding DC servo motor and related parts (the wires are all serially connected in the pipe).

[0103] (4) Servo motor and power supply: DC servo motor with reversible rotation. Power supply: converts AC power into DC power.

[0104] 2. Fully intelligent mechanical production technology solution for targeted injection of 30% hypertonic NaCl solution to treat lung malignancies

[0105] (1) Mechanical part: It includes two parts: the operating table support and the mechanical body.

[0106] (1.1). Surgical bed support: ①. Use aluminum alloy beams with a width of 4 cm and a thickness of 3 cm to weld a rectangular frame with a length of 190 cm and a width of 50 cm. A stainless steel wire mesh with an appropriate mesh is welded inside the frame, and a dense artificial sponge pad with a thickness of 4 cm wrapped with anti-pollution material is placed on top. A rectangular frame made of rigid metal with a thickness of 12 cm and a width of 10 cm is welded on the four sides of the frame. A trapezoidal groove with a width of 6 cm at the top, a width of 8 cm at the bottom, and a depth of 8 cm is made in the upper rear 1 / 2 of both sides of the frame; ②. A rectangular base is made of cast iron: the long side of the base is 180 cm long and the end side is 80 cm long. The width and thickness of the cast iron are both 14 cm; ③. A nut hole with a diameter of 6 cm is made at 16 cm from both ends of the long side of the rectangular bottom cast iron. Use 4 rigid metal round rods with a length of 80 cm and a screw thread within the range of 16 cm at the bottom. A universal ball with a diameter of 4 cm is installed at the lower end of each screw, and a horizontal rocker with a handle is installed on the top. When the screw wheel is turned clockwise, the universal ball extends to the outside of the nut hole and contacts the floor, which can push the operating bed to move. When the screw wheel is turned counterclockwise, the universal ball retracts into the screw hole, and the base of the bed is fixed to the floor; ④. Four rigid metal round tubes with a length of 80cm, a diameter of 8cm, and a wall thickness of 0.6cm are made with male threads within a range of 5cm outside the two ends, and screwed into the nut holes at the lower part of the two sides of the bed and the upper part of the bottom edge to form the structure of the bed; ⑤. An aluminum alloy metal plate is installed above the outer side of the bed facing the patient's shoulders on both sides, forming a 70-degree angle with the outer side of the bed. The support plate supports the patient's upper limbs during surgery, and uses Velcro straps to tie and fix the upper part of the upper limbs, elbows, and wrists (the knees and hips also need to be tied to the bed with Velcro straps_).

[0107] (1.2). Mechanical body and other auxiliary devices: ①. Left and right motion bridge (equivalent to the leg): A rectangular metal strip with a length of 180cm, a width of 16cm, and a thickness of 8cm is made of rigid metal to form an arc-shaped body. Trapezoidal bodies are welded on both ends of the arc-shaped body of the metal strip, which can be inserted into the trapezoidal grooves on both sides of the bed frame. A servo control unit (DC servo motor + intelligent control power module) is installed at the rear of each of the two trapezoidal bodies to drive the gears. The gears are stuck in the toothed grooves on both sides of the trapezoidal groove to drive the arc-shaped mechanical bridge to move forward and backward, which can drive the mechanical body to move forward and backward; ②. "Trunk": A rigid metal tube with a diameter of 10cm and a length of 20cm. One end of the two sections of the tube is cut off and welded into a right-angled structure. The long end is appropriately polished and the lower end matches the shape of the upper part of the arc-shaped trapezoidal body made of metal. It is vertically welded above the trapezoidal body in the 16cm long trapezoidal groove (the opening faces forward), which is equivalent to the trunk of the mechanical body. A servo control unit (DC servo motor + intelligent control power module) is installed on the upper part of the lower trapezoidal body to push the body to move back and forth on the left and right sides of the patient's body; ③. Upper arm: A 10cm diameter aluminum alloy tube is made into a 34cm high "Z" shape (the middle vertical is straight). Insert the horizontal part of the upper part of the "Z" shape into the forward opening of the upper part of the trunk to form a joint that can rotate 90 degrees to the left and right, and install a servo control unit.

[0108] ④. "Forearm": Made of aluminum alloy tube. 10cm in diameter, 36cm in length. The distal end of the upper arm and the proximal end of the forearm are made into a joint that can swing left and right at an angle of 45 degrees. A set of DC servo control units are installed. A syringe sleeve clamp is welded on the front and rear directions of the upper and outer sides of the forearm, which can be clamped with syringe sleeves of different sizes (sleeves have different models: sleeves for 1ml, 5ml, 10ml, and 20ml syringe needles). Each syringe sleeve has a round hole at the distal end, and the nipple of the syringe barrel extends from the round hole to the outside of the front barrel (a thick needle is put on the nipple, and the needle stem is cut short, leaving only 2cm of the needle stem to cover the near end of the hard plastic tube). A 4cm wide metal strip is installed in the cavity of the forearm, and the proximal end of the metal strip has a 5cm upward bend at 90 degrees, and extends to the outside from a 4cm wide long opening from near the proximal end to near the distal end made above the cavity wall of the forearm. A set of tools is installed inside to coordinate and push the piston in the syringe barrel to achieve the purpose of injecting 30% hypertonic NaCl solution into the interstitial tissue of the malignant tumor and its surrounding tissues; ⑤. "Wrist" part: made of aluminum alloy tube. The wrist is 10 cm long and 9 cm in diameter. There is a joint at the proximal end of the wrist and the distal end of the forearm that can rotate 45 degrees forward and backward (the joint can make the injection needle insert into the malignant tumor under the ribs forward and backward: the power is a set of DC servo control units (DC servo motor + intelligent control power module). In front of the aluminum alloy tube of the wrist, there is a welded aluminum alloy cuboid with a length of 25 cm, a width of 4 cm, and a thickness of 4 cm (the middle part of the cuboid is welded to the wrist). A trapezoidal groove is made from top to bottom on the front side of the cuboid; a suitable trapezoidal body with a length of 25 cm is installed in the trapezoidal groove; a rectangular socket (depth of 2 cm) is made at the front and lower part of the trapezoidal body, which can just insert and fix the "finger" holding the needle. The "finger" is made of stainless steel plate: 6 cm long, 2 cm wide, and 0.2 cm thick. A penetrating hole with the same diameter as the stem of the injection needle is drilled on the 0.2 cm wide finger surface 0.5 cm away from the distal end. The needle stem is fixed with a nut and a screw at the far end. The proximal end of the needle stem is covered with a hard plastic tube and connected to the far end of the syringe nipple stuck on the forearm; the other end of the plastic tube covers the needle stem on the syringe nipple. A penetrating, 0.5 cm wide long opening is made from the bottom of the trapezoidal groove close to the top to the bottom. A set of DC servo control units (DC servo motor + intelligent control power module) is installed in the distal lumen of the wrist, driving a gear to extend from the long opening at the bottom of the trapezoidal groove to the outside of the trapezoidal groove, clamping the longitudinal tooth groove on the rear side of the trapezoidal body to drive the trapezoidal body (the long needle for injection is fixed at the front and bottom). The movement completes the work of inserting the needle into the stroma of the malignant tumor and the surrounding tissue stroma; ⑥. After the appropriate parts of each joint are fixed. A sensor is installed to monitor the joint movement (monitoring position and angle) and feedback the information obtained to the numerical control device. After verification, the verified situation is used to correct the control joint program at the far end.

[0109] (2) Programming and transfer of program carriers: Use a common computer or automatic programming machine to program using G code. Store the compiled program on a USB flash drive. During surgery, insert the USB flash drive into the socket of the numerical control device of the operating room computer to provide the program to the computer numerical control device.

[0110] (3) Input / output device: The function of the input device is to transfer the CNC code on the program carrier (information carrier) and store it in the CNC system. Output interface circuit, the output is to decode the G code program into various digital information and instructions: control the injection program or motion program of intelligent mechanical equipment, detect the status of the switch, etc. Input and output various information and instructions. Keyboard and display are the most basic input / output devices required for any CNC equipment. In addition, it can also be equipped with an optical reader, a floppy disk drive, etc. Computer is one of the commonly used input / output devices (it is planned to use an industrial control computer, IPC).

[0111] (4) Numerical control device: Numerical control device is the core device of intelligent mechanical equipment. It consists of input / output interface circuit, controller, memory and other parts. The function of the numerical control device is to compile, calculate and process the data input by the input device through the internal logic circuit or control software, and output various information and instructions to control the various parts of the mechanical equipment to perform the prescribed actions. Automatically complete the treatment task of injecting hypertonic NaCl solution into lung malignant tumors. Because the special industrial control computer itself contains the controller, operation Calculator and memory and other units, so the function of the numerical control device of the machine equipment is completed by an industrial control computer (IPC). Use an ordinary computer or a special programming machine to store the program written in G code on a USB flash drive, and then transfer it to the numerical control device of the industrial control computer when needed to convert the G code of the program into digital. In other words, the industrial control computer has the function of a numerical control device, can logically process programs with control codes or other symbolic instructions, and use digital representations converted from codes. After calculation and processing, it can send various control signals to control the action of mechanical equipment. Modern numerical control processing devices generally use multiple microprocessors to realize numerical control functions in the form of programmed software. It is best not to use the industrial control computer of mechanical equipment for programming. It is placed in the operating room. Whenever someone enters and leaves the operating room, the operating room must be fully disinfected. Instead, use an automatic programming machine or industrial control computer away from mechanical equipment to program and store it on a USB flash drive for use.

[0112] (5) Servo drive device: servo motor plus intelligent power module (IPM). The servo controller constitutes the servo control unit. The servo control system refers to the feedback control system used to accurately follow or reproduce a process. Before submitting the invention patent application, the latest servo control system that has developed into a servo motor and a servo controller has begun to use a new module that integrates the control circuit function and high-power electronic switching devices, called intelligent power module (IPM). This device integrates input isolation, energy braking, over-temperature, over-voltage, over-current protection and fault diagnosis functions into a small module. Its input logic level is fully compatible with TTL signals and can be directly interfaced with the output of the microprocessor. Its application significantly simplifies the design of the servo unit and realizes the miniaturization and micro-miniaturization of the servo system.

[0113] (6) Feedback device: According to the needs of the designed machine, purchase a suitable model of sensor-controller integrated equipment. Install it step by step according to the actual model manual. The sensor converts the sensed information (such as speed, angle position...information) into electrical signals or digital signals, preferably digital signal output. These signals are then transmitted to the controller, which processes data and makes decisions based on the information provided by the sensor, and then outputs control signals to the actuator (select the appropriate type of electric actuator and pay attention to correct wiring). The actuator performs relevant actions based on the control signal.

[0114] (7). Industrial control computers for fully intelligent injection machinery and equipment: Most of the above functions are derived from the functions of industrial control computers. Nowadays, CNC machine tools tend to use industrial control computers that integrate input, output and control functions to assist operators in operation and reduce the error rate. The author also uses industrial control computers (IPC) in intelligent injection machinery and equipment. Industrial control computers (IPC) have many advantages (reliability, intelligence, real-time, expandability, compatibility, rich software and hardware resources) and few disadvantages. Industrial control computers (IPC) have important computer properties and characteristics, such as computer motherboards, CPUs, hard disks, memory, peripherals and interfaces, operating systems, control networks and protocols, computing power, and friendly human-computer interfaces. The industrial control computer system can logically process programs specified by control codes or other symbolic instructions, and convert them into Decoding, expressed in coded numbers. The program is input into the CNC through the information carrier, and various control signals are sent out by the CNC device after calculation and processing to control the mechanical equipment that injects 30% hypertonic NaCl solution into the lung malignant tumor, automatically completing the task of treating lung malignant tumor. The workbench for placing the industrial control computer chassis is made of aluminum alloy: the lower feet of the four legs are equipped with casters and brakes; the required industrial control computer should be customized (the design of the interface needs to meet the needs of specific external equipment). The situation of lung malignant tumor is complicated: sometimes there are metastatic malignant tumor lesions in both lungs, and often multiple malignant tumor lesions. In order to prevent occasional local errors in the program, a set of keyboard encoders needs to be installed (select the most suitable one for programming, and the keyboard encoder that uses G code to program).

[0115] 3. Design and produce technical solutions for radiation protection overalls to protect doctors working in front of digital X-ray (DR) cameras: The general features are: ①. To fully meet the national requirements for radiation shielding for radiation-related practitioners; ②. Loose standing collar, 1cm gap from the neck skin, tops connected to pants, long zipper from chin to pubic symphysis (the radiation protection material on one side of the zipper grows 3cm to the opposite side). The radiation protection function is x

[0116] Line transmission = 0mSv; ③. The radiation shielding material of the work clothes is the space suit radiation protection material developed by the Australian National University; the lining is made of anti-pollution material; ④. The gloves with five separated fingers are made of space suit radiation protection material; ⑤. The helmet is made by modifying the electric bicycle helmet: a layer of 0.6cm thick lead plate is added to the helmet shell, and the two sides and the back extend downward and slightly turned outward, similar to the bottom edge of the ancient warrior hat. The front windshield is changed to 1cm thick white transparent lead glass, 3cm longer upward and 5cm longer downward; it is flattened against the eyes (4cmx6cm each). There are 6 circular holes with a diameter of 1cm on the helmet wall, which is equivalent to the top of the pillow. The upper part is covered with a semicircular helmet shell and a 0.6cm lead plate, and the opening is backward. There is a clip-on microphone on the front lower edge of the helmet (the wireless speaker is installed in the left chest pocket); ⑥. A belt with two sides is made between the shoulder blades

[0117] The backpack of the shoulder strap packs the battery: 35cm high, 25cm wide, and 25cm thick; ⑦. A round canvas tube is sewn on the back and outside of the backpack to hold a 14W inward exhaust fan. The top of the fan is a stainless steel wire mesh, and a stainless steel wire fan cover is added on it. The stainless steel wire fan cover is connected to the fan wall with a hinge. On the opposite side, an elastic steel sheet is installed with a card on the fan wall: press down to get stuck, and lift up to open. 3-4 layers of mask cloth are clamped under the cover, and it is replaced after each use. There is a 3cm diameter corrugated tube at the bottom of the fan that extends to the outside, and its free end has a bayonet that is stuck with the mouth of the corrugated tube extending from the inside of the clothes. The corrugated tube is divided into two upward and downward sleeves on the inner side of the back of the top (the tube wall is solid and smooth, about 3cm long). After applying special glue, two 3cm diameter canvas tubes are put on downward and upward to make the two firmly combined. There are 0.2mm laser holes distributed on the canvas tube wall. The two tubes extend downward to the waist and turn forward and downward along the groin to the inner side of the knee for sealing (the canvas tubes should be sewn intermittently on the lining of the radiation protection suit). The two upward sleeves are put on the two canvas tubes and go up along the two sides of the backpack, crossing the shoulders and going down to the xiphoid process and turning upward to the sternum, and the two openings are sewn together at the sterno-clavicular joint. The canvas tube is connected to the lining of the suit with intermittent sewing. A pocket of the right size to fit the speed regulator is installed on the right chest of the suit. The pocket is equipped with a zipper. A large round hole is cut on the front wall of the bag to just expose the adjustment button and the surrounding scale. The wires are run on the inside of the lining of the suit.

[0118] 4. Meter for measuring the amount of injected hypertonic NaCl solution: modified from a vortex flowmeter: ①. Reduced: The water pipe is 2.4cm long, 1.2cm in outer diameter, and 0.6cm in inner diameter. A layer of hard rubber is glued to the proximal tube within 0.6cm using special glue, and the nipple of the injection needle can be inserted tightly into the hole; ②. A needle plug is made at the far end, and the nipple just fits the needle. The tiny turbine is installed in a tube with an inner diameter of 0.6cm: the display screen is installed on the right side of the outside of the tube, size: 1cmx1.4cm (with a small battery inside); ②. There is a shaft sleeve with an outer diameter of 0.3cm and an inner diameter of 0.15cm in the center of the turbine, and a small magnet is embedded in the inner wall 0.2cm away from the edge of the mouth. Use an outer diameter of 0.3cm, an inner diameter of 0.15cm, and a chromium-containing stainless steel tube of appropriate length with an iron wire in the center, make it into an L shape, and the long vertical part extends out of the tube wall to connect to the converter in the display screen. The short horizontal line is located in the center of the sleeve and faces the rear. A 0.1 cm hole is made on its outer wall to reach the iron wire in the center. After the turbine is installed, the magnet on the sleeve and the hole exposing the iron coin are on the same circular track. When the hypertonic NaCl solution is injected, the turbine rotates. The magnetic lines of force are sent to the iron wire once every rotation. They are recorded and converted into liquid volume by the converter, and can be added up multiple times to appear on the display. The display shows the injection volume of the hypertonic NaCl solution. The amount of hypertonic NaCl solution that passes through the turbine once a rotation should be measured in advance and input into the converter.

[0119] 5. Technical solution for producing radiation shielding clothing for patients with malignant tumors

[0120] 5.1. Technical solution for producing radiation shielding blankets for abdomen and lower limbs: Made of semi-silver fiber blended fabric. Semi-silver fiber fabric refers to fabric blended with silver fiber and polyester and other fibers, which can be washed. Fold into two layers and cut into 120cmx80cm rectangular blocks, lock the periphery together, and cover the outside with anti-pollution material. Cover the abdomen and lower limbs during surgery.

[0121] 5.2. Technical solution for producing chest shielding radiation-proof quilt: use all-silver fiber knitted fabric. The silver fiber here is not pure silver, but a new type of composite fiber fused with silver ions and ordinary fabrics. Breathable, washable, antibacterial and stable shielding performance. Three layers are stacked together, and a layer of anti-pollution material is added on both sides. They are cut into: 3 pieces of 50cmx30cm, 2 pieces of 40cmx20cm, and 1 piece of 40cmx15cm (the blank area under the shielding neck hood), and the 4 edges are locked to form a whole. One side of the 4 sides of each of the above pieces is hit with one side of the Velcro, and the other side of the 4 sides of the other side is hit with the other side of the Velcro. When the hand is wooden, windows of different sizes can be formed on the chest for X-ray observation and injection of hypertonic NaCl solution.

[0122] 5.3. Technical solution for making radiation protection hood: Use 1cm thick white transparent lead glass plate to smash into an inverted "U" shaped hood at an appropriate temperature: 50cm high, 40cm wide, and 10cm outward from the bottom of the two sides. The hood is 40cm long from front to back, and should protrude 15cm toward the chest facing the mouth and nose.

[0123] 6. Technical solution for designing and producing radiation-proof studio: When the camera is turned on, the doctor does not wear radiation-proof clothing and moves the radiation-proof studio to the front of the operating table, and the doctor works in the room. Radiation-proof room: front-to-back length: 160cm, left-right width: 200cm, height: 200cm. The frame is welded with triangular iron stainless steel. The floor should be thick (the bottom layer is a 0.4cm thick bridge steel plate, on which is a 0.6cm lead plate, a 2cm wooden floor on the lead plate, and a 0.1cm stainless steel anti-skid plate on the wooden floor. Two wheels (30cm in diameter) are installed at the front and back under the floor. The front two wheels are driven by electric motors for walking. The motor is welded under the bridge steel plate. The four walls and ceilings of the radiation protection room have 0.6cm lead plates on both sides glued with special glue. 0.2cm stainless steel plates are fixed on the stainless steel triangle iron with screws. The front side wall is 140cm high from the ground and a window is installed horizontally: 180cm long and 50cm wide. Two display screens are hung on the window, the right side is the X-ray machine image display screen; the left side is the non-intelligent machine and patient display screen. The window is equipped with 1c mm white transparent lead glass. There is a long table 80cm high under the indoor window. The table is 180cm long and 60cm wide, with 6 drawers. A battery and a joystick with a control motor are placed on the floor in the middle under the table. A door is installed on the back wall of the room. A 20cm diameter air hole is made at each of the two corners on the back side of the floor, and white plastic tubes of the same diameter are installed on the holes, 50cm high. A 20cm diameter air outlet is made at each of the two corners on the front side of the ceiling, and two lead pipes of the same diameter are installed on the top side, 30cm high, with the upper 1 / 2 slightly tilted backwards. On the lower wall of the front window, 5cm away from the window, 5 4cm diameter faucet-like lead pipes (wall thickness 0.6cm) are installed, and the spacing is determined according to needs, which are various line channels; the plastic tube connected to the syringe also passes through here.

[0124] 7. Technical solution for producing handheld injection needles: The needle stem is 0.7mm, 0.55m, or thinner in various specifications; the length of the needle stem of each diameter (referring to the part far from the handle) is 10cm, 1`5cm, 20cm, and 25cm. The needle stem of the 14G needle is cut off by 2cm. The remaining 2cm needle stem is covered with the proximal end of the hard plastic tube, and the plastic tube is connected to the syringe barrel with the help of the 14G needle stem; each injection needle stem is 2cm away from the needle stem, and a soft stainless steel wire with a diameter of 0.15cm is tightly wound to form a 3cm handle to the distal end. The 2cm needle stem on the handle is covered with the distal end of the hard plastic tube.

[0125] 8. Design and produce technical solutions for mechanical handheld injection needles: the needle stem of each needle cover plastic tube and the handle junction are bent at 90 degrees, and the rest of the parts are the same as handheld needles.

[0126] 9. Intelligent robot for injecting hypertonic NaCl solution to treat malignant tumors:

[0127] It is mainly used to treat peripheral lung cancer and metastatic lung cancer.

[0128] Mechanical system: It has a head shell similar to that of a human, neck and neck joints (it can bend its head up to 50 degrees and rotate 35 degrees left and right), chest cavity, upper limbs on both sides, and the range of motion is similar to that of human upper limbs. Abdominal cavity; waist and waist joints: can bend forward 45 degrees, move left and right 30 degrees, lower limbs are short front and back, wide left and right, and are in a rounded cylindrical shape connected to the abdominal cavity, welded above the feet, the feet are square cast iron of 50cmx50cmx20cm, weighing about 30kg. The four corners are polished to be round, and there are four controllable wheels at the bottom. The total height is 165cm.

[0129] Drive system: The drive system enables the robot to move and perform various actions. Electric drive systems are used: including DC servo motors, stepper motors and AC servo motors.

[0130] Control system: The core of the control system is the central processor, which receives information from sensors and issues instructions to control the robot's behavior. The use of microprocessors and various chips makes the robot more intelligent and efficient. The main controller stores the program.

[0131] Perception system: The perception system collects environmental information through various sensors to help the robot make the right response. Sensors: visual sensors, auditory sensors, and tactile sensors (there must be a sufficient number of tactile sensors and actuators on the fingers, palms, and wrists). It can sense the signals in the environment and convert them into electrical signals for the controller to process and judge data. The accuracy and stability of the sensor directly affect the performance of the automation equipment.

[0132] Actuator: It is the power output component of the automation equipment. It drives the mechanical parts to move according to the instructions of the controller. The type and performance of the actuator are closely related to the purpose of the automation equipment. It is possible to consider using integrated sensors and actuators, which have many advantages.

[0133] Programming: With the help of an automatic programming machine, use binary numbers 0 and 1 to program. This language has many advantages, such as high efficiency and better than assembly language. The compiled program is stored in the memory of the main controller. Since there are no two completely identical things in the world, the location, size, and shape of the tumors in different cases of lung malignant tumors are different, so the compiled program should be divided into two parts: (1) routine activity program, (2) treatment program for each case. The program for using the syringe must be detailed, and the method of holding the syringe must be mastered by the intelligent robot.

[0134] (1). Routine activity procedures: ①. Get familiar with the working environment: get to know the operating table, tumor patients, anesthesiologists, digital X-ray machines (conventional, three-dimensional image X-ray machines), syringes, and the injection volume numbers displayed on the flow meter at the front of the syringe...; ②. Learn to use the digital X-ray machine and learn to read the malignant tumor and edge conditions on the display screen; ③. Learn to identify the position of the human chest: left chest, right chest, sternum, ribs, intercostal space, distance from the midclavicular line, inner and outer distances of the anterior axillary line (? cm)... The above-written programs are placed in the program storage of the main controller.

[0135] 2. Each case of lung malignant tumor needs a treatment program: peripheral lung cancer and metastatic malignant tumors of the lung (multiple malignant metastatic tumors should be numbered 1, 2, 3...) The size, shape, and accurate location of each tumor are obtained through CT examination, and a 3D image is printed based on the 3D examination. On this basis, the doctor makes a complete treatment plan for each malignant tumor. The programmer uses an automatic programming machine to compile the treatment program and save it in a USB flash drive. When using it, insert the USB flash drive into the socket on the head of the intelligent robot, connect it to the main controller, and ask it to execute the new program.

[0136] The intelligent robot does not need to learn, improve, or move on its own, it only needs to obey and execute programs.

[0137] Power supply: The intelligent power supply adopts DSP digital control technology, with high precision, low ripple, fast response, good high-voltage output stability, and can be used in parallel and series.

Claims

1. Technical solution for producing non-intelligent machinery for treating lung malignant tumors using hypertonic NaCl solution: The non-intelligent machinery can be divided into: a base (including a bed frame and a bracket), a mechanical body, a DC servo motor supporting a reversal signal, a servo motor control console, and a DC power supply. (1). Base: The base is designed as an operating bed; it consists of a bed frame and a bracket. ①. A stainless steel wire mesh frame with a length of 180cm and a width of 60cm, with a rectangular frame made of rigid metal with a thickness of 14cm and a width of 12cm welded on the four sides; ②. A trapezoidal groove with a width of 6cm at the top, a width of 8cm at the bottom, and a depth of 10cm is made in the upper back 1 / 2 of both sides of the frame; ③. Operating bed bracket: a bridge steel plate: 0.6cm thick, 84cm wide, and 320cm long, with 0.1cm thick stainless steel plates wrapped around the two sides and four edges. Flatten the 100cm long part of the steel plate; then press the two ends of the 100cm plate downward to an angle of 125 degrees, and then fold the two lower 40cm parts toward the center of the bed to form "feet" parallel to the ground, and stick anti-slip material on the "foot soles" with special glue; ④. Place the bed frame on the bracket, align the two sides of the middle part of the bed frame with the two sides of the bracket, and use multiple smaller screws to fix the lower part of the bracket to the lower part of the bed frames on both sides, thus forming a complete operating bed; ⑤. Install an aluminum alloy plate on the upper side of the outer side of the bed facing the patient's shoulders on both sides (the aluminum alloy plate can be extended and retracted). When the aluminum alloy plate is extended, it forms a 70-degree angle with the outer side of the bed. The support board supports the patient's upper limbs during surgery, and uses Velcro straps to secure the upper limbs, elbows, and wrists (knees and hips also need to be tied to the bed with Velcro straps). The bed is covered with an artificial sponge pad wrapped in anti-pollution material. (2) Mechanical body: ①. Aluminum alloy plate is used to make a 0.4cm thick aluminum alloy box (equivalent to the body of the machine) with a height of 30cm, a width of 20cm, and a length of 16cm. The bottom of the box is within 6cm of the chest skin. ②. Corresponding 3m x 6cm horizontal openings are made on the left and right walls of the upper 1 / 3 of the box, and an aluminum alloy arc body (equivalent to the horizontal bridge) of about 180cm long, 3cm thick, and 6cm wide is inserted into the opening. The aluminum alloy box can move left and right along the aluminum alloy bridge. The bottom of the box is 6cm away from the chest skin. A DC servo motor (DC servo motor + reducer) is installed between the aluminum alloy box and the arc bridge to enable the machine body to move left and right: the servo motor driver used in this non-cognitive machine must support reverse input signals. The two ends of the bridge are welded to the upper bottom of a 12cm long trapezoidal body. The trapezoidal body is inserted into the upper part of the two sides of the bed, occupying 1 / 2 of the length of the operating bed. It can slide from the back to the patient's navel. A DC servo motor (DC servo motor + reducer) is installed horizontally on the two trapezoidal bodies, and the gear in front of the motor is embedded with the tooth-like protrusions at equal distances on the inner side of the trapezoidal groove (the tooth-like protrusions are from the rear end to the middle of the operating table); ③. 3cm near the bottom of the aluminum alloy box. 5cm away from the left and right walls, and a 10cm diameter round hole is made in the corresponding direction of the front and rear walls, and a 0.4cm thick aluminum alloy round tube (equivalent to the upper arm) is inserted through it. The length is 40cm and the outer diameter is 10cm. There is a gear groove from front to back on the left side of the corresponding upper arm, and a DC servo motor (DC servo motor + reducer) is installed on the rear wall of the aluminum alloy box corresponding to the gear groove. Its gear engages and links with the gear groove on the upper arm side, so that the upper arm can only move forward and backward; ④. The distal end of the upper arm and the proximal end of the forearm are joints that can rotate 90 degrees left and right. There is a DC servo motor (DC servo motor + reducer) at the joint as the power for joint rotation; ⑤. The forearm is an 8cm long aluminum alloy metal tube, with the wrist joint at the far end. The "palm" connected to the far end of the wrist joint is an aluminum alloy part: the part is an aluminum alloy plate with a length of 6cm, a width of 6cm, and a thickness of 3cm (the upper and lower sides of the plate are perpendicular to the ground, that is, the palm side faces the body surface and the back of the hand faces the outside). A 1cm x 1cm square hole is made from the back of the hand to the palm side on the front and back midline 0.5cm away from the far end of the palm. A rigid 1cm x 1cm x 20cm square metal column is inserted from the back of the hand. A 20cm long tooth groove is made on the upper side of the square column (equivalent to the thumb side when a person lies on his back). A small DC servo motor (DC servo motor + speed reducer) is installed on the back of the hand near the thumb side, and the gear at the front end is just embedded in the tooth groove on the side of the square metal column. The composition of the wrist joint: a section of aluminum alloy cylinder with the same inner diameter as the tubular forearm, 6cm long. 3cm of one end is inserted into the round tube of the forearm, and 3 nuts are made. The forearm and the cylinder are fixed together with 3 screws. A 3cm wide and 3cm deep notch is made in the middle of the far end of the cylinder (equivalent to the position when a person stands with both hands stretched forward and the palms facing down). A 2.5cm long and 3cm wide protrusion is made in the middle of the near end of the "palm", and the protrusion is inserted into the notch at the far end of the forearm. A metal rod is passed through from the side, and the two ends of the metal rod are fixed to form a wrist joint (note that the edges and corners of the upper and lower plate heads are polished into round shapes so as not to affect the movement of the newly formed wrist joint); ⑥. The "fingers" are made of rigid metal plates: 4cm long, 1.5cm wide, and 0.3cm thick. There are 3 in total, which can be installed in the front-to-back and 1.5cm deep opening at the bottom of the square metal bar. A nut is made on the outside and tightened with a screw with a handle to block the "fingers" and prevent them from moving. Drill holes with diameters of 0.75mm, 0.55mm, and even thinner in the vertical direction at 0.5cm from the front end of each metal strip, insert the needle stem of the injection needle, and insert the front end perpendicularly into the needle stem hole. Make a nut with a diameter of 0.15mm to reach the needle stem hole, and screw the screw with a handle into the nut to fix the inserted injection needle stem. Put a hard plastic tube on the 90-degree backward bend at the upper end of the injection needle stem, and put the distal end of the plastic tube on the needle stem 2cm proximal to the 12G needle on the nipple of the syringe barrel filled with hypertonic NaCl solution (the needle stem more than 2cm away is cut off). The doctor is responsible for the injection in the radiation protection room; ⑦. A small servo motor + reducer is installed horizontally on the upper part of the wrist and the forearm (equivalent to the upper side of the forearm when a person stands, stretches both upper limbs forward, and the palms face down). Two U-shaped shafts are installed on the rotating shaft at the front end of the servo motor. The two are close together. When wrapping the leather rope around the two U-shaped shaft grooves, one is wrapped clockwise and the other is wrapped counterclockwise. On the thumb side of the "palm" (equivalent to the upper side when a person lies on the operating table with the palm against the body surface), a steel column with a length of 7 cm and a diameter of 0.6 cm is welded horizontally (the middle part of the steel column is welded to the middle part of the upper side of the palm). There are round holes at both ends of the steel column. The leather strips wrapped around the two U-shaped shafts on the servo are fixed to the two ends of the column respectively. The "palm" can be controlled to bend to one side and the other side through the knee-wrist joint, so the injection needle can be controlled to form an angle forward and backward for injection. (3) Manual control console: A control console is customized from a company. There is a control system for each DC servo motor in the control console. The control console is placed on the front table in the radiation protection room. The lines are connected by professionals. Carefully debug before use. Power supply: The AC power is converted into DC power through four processes: rectification, filtering, voltage regulation and current limiting. Each DC servo motor is connected through the control system (the servo driver must support the reverse signal). There is a reverse signal twist on the control lever. When the control lever is pushed forward, the servo motor rotates counterclockwise. When the lever is pulled back, a reverse signal is sent to the driver, and the servo motor rotates clockwise. Users should remember the role of each servo and be proficient in operation. The wires are concentrated in the control console, gathered into a bundle behind the wall of the control console, and then reach the outside through the lead pipe (faucet-like lead pipe) on the wall of the radiation protection room. They are put into a hard plastic pipe and pulled to the side of the machine. The wires are connected to the corresponding DC servo motor and related parts (the wires are all connected in series in the pipe). (4) Servo motor and power supply: DC servo motor that can be reversed. Power supply: AC becomes DC.

2. Technical solution for producing intelligent mechanical equipment for treating lung malignant tumors using hypertonic NaCl solution: (1) Mechanical part: It includes two parts: the operating table support and the mechanical body. (1.1). Surgical bed support: ①. Use aluminum alloy beams with a width of 4 cm and a thickness of 3 cm to weld a rectangular frame with a length of 190 cm and a width of 50 cm. A stainless steel wire mesh with an appropriate mesh is welded inside the frame, and a dense artificial sponge pad with a thickness of 4 cm wrapped with anti-pollution material is placed on top. A rectangular frame made of rigid metal with a thickness of 12 cm and a width of 10 cm is welded on the four sides of the frame. A trapezoidal groove with a width of 6 cm at the top, a width of 8 cm at the bottom, and a depth of 8 cm is made in the upper rear 1 / 2 of both sides of the frame; ②. A rectangular base is made of cast iron: the long side of the base is 180 cm long and the end side is 80 cm long. The width and thickness of the cast iron are both 14 cm; ③. A nut hole with a diameter of 6 cm is made at 16 cm from both ends of the long side of the rectangular bottom cast iron. Use 4 rigid metal round rods with a length of 80 cm and a screw thread within the range of 16 cm at the bottom. A universal ball with a diameter of 4 cm is installed at the lower end of each screw, and a horizontal rocker with a handle is installed on the top. When the screw wheel is turned clockwise, the universal ball extends to the outside of the nut hole and contacts the floor, which can push the operating bed to move. When the screw wheel is turned counterclockwise, the universal ball retracts into the screw hole, and the base of the bed is fixed to the floor; ④. Four rigid metal round tubes with a length of 80cm, a diameter of 8cm, and a wall thickness of 0.6cm are made with male threads within a range of 5cm outside the two ends, and screwed into the nut holes at the lower part of the two sides of the bed and the upper part of the bottom to form the structure of the bed; ⑤. An aluminum alloy metal plate is installed on the upper part of the outer side of the bed facing the patient's shoulders on both sides, forming a 70-degree angle with the outer side of the bed. The support board supports both upper limbs of the patient during surgery, and uses Velcro straps to secure the upper limbs, elbows, and wrists (the knees and hips are also secured to the bed with Velcro straps). (1.2). Mechanical body and other auxiliary devices: ①. Connecting the left and right arc bridges: A rectangular arc body with a length of 180cm (tentative), a width of 16cm, and a thickness of 8cm is made of rigid metal. Trapezoidal bodies are welded on both ends of the arc body, which can be inserted into the trapezoidal grooves of the two sides of the bed frame. A servo control unit (DC servo motor + intelligent control power module) is installed at the rear of each of the two trapezoidal bodies to drive the gears. The gears are stuck in the toothed grooves on the inner sides of the two trapezoidal grooves to drive the arc bridge to move forward and backward; a trapezoidal groove is made on the top of the arc bridge: the upper bottom is 12cm wide, the lower bottom is 14cm wide, the upper and lower bottoms are 6cm apart, and a toothed groove is made on one side. A slightly arc-shaped trapezoidal body with a length of 16cm is installed in the groove; ②. "Trunk": two rigid metal tubes with a diameter of 10cm and a length of 20cm. A part of one end of the two tubes is cut off obliquely and then welded into a right-angle structure. The end of a tube is properly polished to match the shape of the upper part of the arc-shaped trapezoidal body made of metal, and welded vertically to the bottom of the trapezoidal body with a length of 16 cm. The opening of the upper tube faces forward. A servo control unit (DC servo motor + intelligent control power module) is installed on the outside of the vertical tube (left or right side). A gear is installed at the front end of the servo motor to fit the toothed groove on the edge of the trapezoidal groove, pushing the "body" to move back and forth on the left and right sides above the patient's body; ③. Upper arm: A 10cm diameter aluminum alloy tube is made into a "Z" shape with a height of 34cm (tentative) (the middle vertical is straight). The upper part of the "Z" shape is 4cm long horizontally. A section of aluminum alloy round tube, 6cm long, its outer diameter is equal to the inner diameter of the body tube and the "Z" tube. The 4cm proximal end of a horizontal section is inserted into the tube with an opening facing forward at the upper part of the trunk, forming a joint that can rotate 90 degrees to the left and right. A servo control unit (DC servo motor + intelligent control power module) is installed in the tube with an opening facing forward of the "body". The distal 2 cm is fixed in the horizontal tube at the upper part of the "Z"-shaped tube; ④. "Forearm": Made of aluminum alloy tube. Diameter 10cm, length 46cm. Make sliding joints between the distal end of the upper arm and the proximal end of the forearm that can be extended forward and backward: The horizontal length of the lower part of the "Z"-shaped tube is 20ccm. A section of aluminum alloy round tube, 18cm long, its outer diameter is equal to the inner diameter of the "Z"-shaped tube and the forearm tube. The 3cm of the distal end of the 18cm long aluminum alloy round tube is fixed in the tube cavity at the proximal end of the forearm, and the remaining 15cm is made into longitudinal openings of 0.4cm width and 12cm length on both sides, and longitudinal serrated grooves are made on the upper part, and then inserted into the horizontal tube at the lower part of the "Z"-shaped tube. Then, from both sides of the lower part of the "Z"-shaped tube, a metal sheet of 1cm width, 0.4cm thickness and 1.2cm length is inserted 1cm away from the tube mouth (the metal sheet is just inserted into the longitudinal opening of the inner tube wall, and the metal sheet is fixed to the outer tube wall on the outside, with a range of motion of about 15cm linear sliding. A DC servo control unit (DC servo) is installed on the upper part of the lower part of the "Z"-shaped tube. The servo motor + intelligent control power module) drives the gear, and clamps the tooth groove on the upper part of the inner tube through the 2cm longitudinal opening on the tube wall to make the forearm slide forward and backward. A syringe sleeve clamp is welded on the front and rear directions of the upper outside of the forearm, which can be equipped with sleeves of syringes of different sizes (the sleeves have different models: there are sleeves for 1ml, 5ml, 10ml, and 20ml syringe needles). Each syringe sleeve has a round hole at the distal end, and the nipple of the syringe barrel extends from the round hole to the outside of the front barrel (a thick needle is put on the nipple, and the needle stem is cut short, leaving only the proximal 2cm needle stem to cover the proximal end of the hard plastic tube). A 4-inch wide needle that can be pulled forward and backward is installed in the cavity of the forearm. The metal strip has a 90-degree upward bend of 5 cm at the proximal end of the metal strip, and extends from the upper side of the cavity wall of the forearm to the outer upper side (moving back and forth along the 4 cm wide and 18 cm long opening away from the mouth of the syringe barrel (a device for sliding the metal strip back and forth is installed on the inner upper wall of the forearm metal barrel). A servo control unit (DC servo motor + intelligent control power module) is installed in the forearm metal barrel to push the piston in the syringe barrel to achieve the purpose of injecting 30% hypertonic NaCl solution into the interstitial tissue of the malignant tumor and its surrounding tissues; ⑤. "Palm" part: made of aluminum alloy tube, the "palm" has a diameter of 10 cm and a length of 5 cm Aluminum alloy tube. Drill a 0.4cm diameter round hole on the front and back walls 1cm away from the upper edge of the "palm" (when the person is standing at attention, with the palm facing the trouser line). Bend 0.5cm of one end of two aluminum alloy rods with a diameter of 0.4cm and a length of 4.5cm by 90 degrees, and insert the 0.5cm side into the 0.4cm diameter round hole (free to rotate); the upper 1cm of the two aluminum alloy rods are welded to the outside of the front and back tube walls of the forearm respectively (cannot move). Use rigid metal to make hemispheres with a diameter of 10cm, and weld them to the inner and outer edges of the proximal end of the "palm" aluminum alloy tube, and make a serrated groove on the equator from the "palm" to the "back of the hand".A small-sized, high-torque servo control unit (DC servo motor + intelligent control power module) is installed horizontally in the tube at the far end of the forearm, and the gear in front of it just catches the toothed groove of the hemispherical equator. The servo can rotate clockwise or counterclockwise, driving the "palm" to rotate 45 degrees inward and outward. (This joint can tilt the injection needle forward and backward, making it easier to insert the needle into the malignant tumor under the upper and lower ribs for injection). A 25cm long, 4cm wide, and 4cn thick aluminum alloy cuboid is welded on the front end of the palm (vertical to the body surface when standing at attention). A trapezoidal groove is made from top to bottom on the front side of the cuboid; a suitable trapezoidal body with a length of 25cm is installed in the trapezoidal groove (there is a toothed groove from top to bottom on the bottom midline of the bottom when standing at attention); a rectangular socket (2cm deep) is made on the front and lower part of the trapezoidal body, which can just insert and fix the "finger" holding the needle. There is a nut on one side, and a screw with a handle is used to fix the finger so that it cannot move. The "finger" is made of stainless steel plate: 6cm long, 2cm wide, and 0.2cm thick. A penetrating circular hole with a diameter substantially the same as that of the injection needle stem is drilled on the 0.2cm wide surface 0.5cm away from the distal end of the "finger" to insert the injection needle stem. A nut perpendicular to the needle stem hole is drilled at the distal end of the finger, and the injection needle stem is fixed with a screw. A hard plastic tube is put on the proximal end of the needle stem to connect with the needle stem at the distal end of the injection syringe nipple stuck above the forearm. A penetrating, 0.5cm wide long opening is made from the bottom of the trapezoidal groove from the top to the bottom. A small DC servo control unit (DC servo motor + intelligent control power module) is installed horizontally on the "back of the hand" side near the distal end of the "palm", driving a gear from the long opening at the bottom of the trapezoidal groove to the trapezoidal groove, clamping the longitudinal tooth groove on the rear side of the trapezoidal body to drive the trapezoidal body (the "finger" with the long needle for injection fixed at its front and lower part) to move downward to complete the insertion of the needle into the interstitial tissue of the malignant tumor and its surrounding tissues. When the needle is pulled out, the trapezoidal body moves upward;. ⑥. After each joint is installed, install a suitable sensor-actuator integrated device at the appropriate position of each joint (see the feedback device below). (2) Programming and transfer of program carriers: Use a common computer or automatic programming machine to program in G code, and store the program on a USB flash drive. During surgery, insert the USB flash drive into the socket of the CNC device of the operating room computer to provide the program to the computer CNC device. This machine partially imitates the closed-loop control CNC machine tool, so it adopts closed-loop control. (3) Input / output device: The function of the input device is to transfer the CNC code on the program carrier (information carrier) and store it in the CNC system. Output interface circuit, the output is to decode the G code program into various digital information and instructions: control the injection program or motion program of intelligent mechanical equipment, detect the status of the switch, etc. Input and output various information and instructions. Keyboard and display are the most basic input / output devices required for any CNC equipment. In addition, it can also be equipped with an optical reader, a floppy disk drive, etc. Computer is one of the commonly used input / output devices (it is planned to use an industrial control computer, IPC). (4) Numerical control device: Numerical control device is the core device of intelligent mechanical equipment. It consists of input / output interface circuit, controller, memory and other parts. The function of the numerical control device is to interpret, calculate and process the data input by the input device through the internal logic circuit or control software, and output various information and instructions to control the relevant parts of the mechanical equipment to perform the specified actions. Automatically complete the treatment task of injecting hypertonic NaCl solution into lung malignant tumors. Because the special industrial control computer itself contains the controller, operation Calculator , memory, output instructions and other units mentioned above, so the function of the numerical control device of the machine equipment is completed by an industrial control computer (IPC). Use an ordinary computer or a special programming machine to store the program compiled in G code on a USB flash drive, and then input it into the numerical control device of the industrial control computer when needed to convert the G code of the program into numbers. In other words, the industrial control computer has the function of a numerical control device, can logically process programs with control codes or other symbolic instructions, and use codes to convert digital representations. After calculation and processing, it can send various control signals to control the relevant parts of the mechanical equipment to perform specified actions. It is best not to use the industrial control computer of mechanical equipment for programming. It is placed in the operating room. Whenever someone enters and leaves the operating room, the operating room must be fully disinfected. Instead, use an automatic programming machine or industrial control computer far away from the mechanical equipment to program and store it on a USB flash drive for use. (5) Servo drive device; using servo motor plus intelligent control power module (Intelligent Power Modules, IPM for short). That is, the servo motor plus the intelligent control power module constitutes a servo control unit. The function of the servo control system is to accurately follow or reproduce a feedback control system of a process. Before submitting the patent application for this invention, the latest servo control system that has developed into servo motor and servo controller has begun to use a new module that integrates the control circuit function and high-power electronic switching devices, called Intelligent Control Power Modules (IPM for short). This device integrates input isolation, energy consumption braking, over-temperature, over-voltage, over-current protection and fault diagnosis functions into a small module. Its input logic level is fully compatible with TTL signals and can be directly interfaced with the output of the microprocessor. Its application significantly simplifies the design of the servo unit and realizes the miniaturization and micro-miniaturization of the servo system. (6) Feedback device: According to the needs of the designed machine, purchase a suitable model of sensor-controller integrated equipment. Install according to the actual model manual. The sensor converts the sensed information (such as speed, angle, position... information) into electrical signals or digital signals, preferably digital signals. These signals are then transmitted to the controller, which processes data and makes decisions based on the information provided by the sensor, and then outputs control signals to the actuator (select the appropriate type of electric actuator and pay attention to correct wiring). The actuator performs relevant actions based on the control signal. (7). Industrial control computers for key equipment of intelligent injection machinery: Intelligent machinery is a tool of the computer series, and most of the above devices are closely related to computers. Industrial personal computers (IPCs) that integrate input, output, and control functions are used. Industrial personal computers (IPCs) have many advantages (reliability, intelligence, real-time, expandability, compatibility, and rich software and hardware resources). Industrial personal computers (IPCs) have important computer attributes and characteristics, such as computer motherboards, CPUs, hard disks, memory, peripherals and interfaces, and operating systems... The industrial control computer system can logically process programs specified by control codes or other symbolic instructions and Decoding , expressed in coded numbers. The program is input into the CNC through the information carrier, and after calculation and processing, the CNC device sends various control signals to control the mechanical equipment that injects 30% hypertonic NaCl solution into the lung malignant tumor, automatically completing the task of treating lung malignant tumor. A workbench for placing the industrial control computer chassis is made of aluminum alloy: the bottom of the four legs are equipped with casters and brakes; the required industrial control computer should be customized. The industrial control computer is placed in a dry, ventilated place with the display screen at a proper distance from the user.

3. Design and produce technical solutions for radiation protection overalls to protect doctors working in front of digital X-ray (DR) cameras: The general features are: ①. To fully meet the national requirements for radiation shielding for radiation-related practitioners; ②. Loose stand-up collar, 1 cm gap from the neck skin, tops connected to pants, long zipper from chin to pubic symphysis (radiation protection material on one side of the zipper extends 3 cm to the opposite side). Radiation protection function is x-ray transmittance = 0 mSv; ③. The radiation shielding material of the overalls uses the radiation protection material of space suits developed by the Australian National University; the lining uses anti-pollution material; ④. Gloves with five separate fingers are used to make radiation protection materials for space suits; ⑤. The helmet is made by modifying an electric bicycle helmet: a layer of 0.6cm thick lead plate is added to the helmet shell, and the sides and back extend downward to the shoulders and the lower back of the neck, and slightly turned outward, similar to the lower edge of the ancient warrior hat. The front windshield is changed to 1cm thick white transparent lead glass, 3cm longer upward and 5cm longer downward; a plane with a horizontal length of 18cm and a width of 6cm is pressed out facing the eyes. There are 6 round holes with a diameter of 1cm on the wall of the helmet, which is equivalent to the top occipital part. The upper part is covered with a semicircular helmet shell and a 0.6cm lead plate, and the opening is backward. There is a clip-on microphone on the front lower edge of the helmet (the wireless speaker is installed in the left chest pocket); ⑥. A backpack with straps on both sides is made between the shoulder blades to pack batteries: 35cm high, 25cm wide, and 25cm thick; ⑦. A round canvas tube is sewn on the back and outside of the backpack to hold a 14W inward exhaust fan. The top of the fan is a stainless steel wire mesh, and a stainless steel wire fan cover is added on it. The stainless steel wire fan cover is connected to the fan wall with a hinge. On the opposite side, an elastic steel sheet is installed with a card on the fan wall: press down to get stuck, and lift up to open. 3-4 layers of mask cloth are clamped under the cover, and they are replaced every time they are used. There is a 3cm diameter corrugated tube at the bottom of the fan that extends to the outside, and its free end has a bayonet that is stuck with the mouth of the corrugated tube extending from the inside of the clothes. The corrugated tube is divided into two upward and downward sleeves on the inside of the back of the top (the tube wall is solid and smooth, about 3cm long). After applying special glue, two 3cm diameter canvas tubes are put on downward and upward to make the two firmly combined together. There are 0.2mm laser holes distributed on the canvas tube wall. The two extend downward to the waist and turn to the front lower edge of the groin to the inner side of the knee for sealing (the canvas tube should be intermittently sewn on the lining of the radiation protection suit). The two upward sleeves are put on two canvas tubes and go up along the two sides of the backpack, crossing the shoulders and going down to the xiphoid process and turning upward to the sternum, and the two openings are sewed together at the sternoclavicular joint. The canvas tube is connected to the lining of the clothes with intermittent sews. A pocket of the right size to fit the speed regulator is installed on the right chest of the clothes. The pocket is equipped with a zipper. A large round hole is cut on the front wall of the bag to just expose the adjustment button and the surrounding scale. The wires are run on the inside of the lining of the clothes.

4. Technical solution for producing a meter for measuring the amount of injected hypertonic NaCl solution: It is manufactured in imitation of a vortex flowmeter: ①. Reduced: The water pipe is 2 cm long, 1 cm in outer diameter, and 0.8 cm in inner diameter. A 0.5 cm long tube is made at the proximal end to insert the nipple of the injection syringe. A section of hard rubber tube is glued to the inside of the tube, and the nipple of the injection syringe can be tightly inserted into the lumen of the tube; ②. A needle plug is made at the distal end to fit the nipple of the injection needle. A turbine with a diameter of 0.7 cm is installed in a tube with an inner diameter of 0.8 cm: the display screen is installed on the right side of the outside of the tube, with a size of 2 cm long x 1.5 cm wide (with a converter and a small battery inside); ③. There is a shaft sleeve with an outer diameter of 0.4 cm and an inner diameter of 0.2 cm in the center of the turbine, and a small magnet is embedded in the wall of the shaft sleeve 0.15 cm away from the proximal edge. A section of chromium-containing stainless steel tube with an outer diameter of 0.2 cm, an inner diameter of 0.05 cm, and an appropriate length is used, and an iron wire with a diameter of 0.05 cm is installed in the center. A metal rod with an outer layer containing chromium and an inner iron wire is made into an "L" shape. The long vertical part of the "L" shape extends out of the tube wall and is connected to the converter in the display screen. The short horizontal part is located in the center of the tube with a diameter of `0.8 cm, facing the rear. A 0.1 cm hole is made on the wall of the stainless steel with an outer diameter of 0.2 cm, reaching the iron wire in the center. After the turbine is installed, the magnet on the sleeve and the hole exposing the iron coin are on the same circumferential track. When the hypertonic NaCl solution is injected, the turbine is rotated, and a magnetic line of force is sent to the iron wire once every rotation. It is recorded in the converter (equivalent to a simplified microprocessor) and can be automatically converted into liquid volume. The total amount of hypertonic NaCl solution (i.e. the total amount of hypertonic NaCl solution injected) can be added up to display the total amount of hypertonic NaCl solution (i.e. the total amount of hypertonic NaCl solution injected) on the display screen. The number marked on the display screen is the injection amount of hypertonic NaCl solution. The amount of hypertonic NaCl solution that passes through the turbine during one revolution must be measured in advance and input into the converter for automatic calculation.

5. Technical solution for producing radiation-proof quilts for patients with malignant tumors: 5.

1. Technical solution for producing radiation shielding blankets for abdomen and lower limbs: Made of semi-silver fiber blended fabric. Semi-silver fiber fabric refers to fabric blended with silver fiber and polyester and other fibers, which can be washed. Fold into two layers and cut into 120cmx80cm rectangular blocks, lock the periphery together, and cover the outside with anti-pollution material. Cover the abdomen and lower limbs during surgery. 5.

2. Technical solution for producing chest shielding radiation-proof quilt: use all-silver fiber knitted fabric. The silver fiber here is not pure silver, but a new type of composite fiber fused by silver ions and ordinary fabrics. Breathable, washable, antibacterial and stable shielding performance. Three layers are stacked together, and a layer of anti-pollution material is added on both sides. They are cut into: 3 pieces of 50cmx30cm, 2 pieces of 40cmx20cm, and 1 piece of 40cmx15cm (the blank area under the shielding neck hood), and the 4 edges are locked to form a whole. One side of the 4 sides of each of the above pieces is hit with one side of the Velcro, and the other side of the 4 sides of the other side is hit with the other side of the Velcro. During surgery, windows of different sizes can be formed on the chest for X-ray observation and injection of hypertonic NaCl solution. Shielding the chest against radiation is of great significance and cannot be ignored. 5.

3. Technical solution for making radiation protection hood: Use 1cm thick white transparent lead glass plate to smash into an inverted "U" shaped hood at an appropriate temperature: 50cm high, 40cm wide, and 10cm outward from the bottom of the two sides. The hood is 40cm long from front to back, and should protrude 15cm toward the chest facing the nose and mouth.

6. Technical solution for producing radiation-proof studio: When the camera is turned on, the doctor does not wear radiation-proof clothing and moves the radiation-proof studio to the front of the operating table, and the doctor works in the room. Radiation-proof room: front-to-back length: 180cm, left-right width: 200cm, height: 200cm. Use stainless steel to make a triangle iron welded into a frame. The floor should be thick (the bottom layer is a 0.4cm thick bridge steel plate, on which is a 0.6cm lead plate, a 2cm wooden floor on the lead plate, and a 0.1cm stainless steel anti-skid plate on the wooden floor. Two wheels (12cm in diameter) are installed at the front and back of the floor. The front two wheels are driven by electric motors for walking. The motor is welded under the bridge steel plate. The four walls and ceiling of the radiation protection room: 0.2cm stainless steel plates are glued on both sides of the 0.6cm lead plate with special glue and fixed to the inner side of the stainless steel triangle with screws. The front side wall is 120cm high from the ground and a window is installed horizontally: 180cm long and 50cm wide. Two display screens are hung on the window: the right side is the X-ray machine image display screen; the left side is the non-intelligent machine and patient display screen. The window is equipped with 1cmm white Colored and transparent lead glass. There is a long table 80cm high under the indoor window. The table is 180cm long and 60cm wide, with 6 drawers. A battery and a joystick with a control motor are placed on the floor in the middle under the table. A door is installed on the back wall of the room. Two air inlets with a diameter of 20cm are made at the two corners on the back side of the floor, and white plastic tubes with the same diameter and a height of 50cm are installed on the holes. Two air outlets with a diameter of 20cm are made at the two corners on the front side of the ceiling, and two lead tubes with the same diameter and a height of 30cm are installed on the top side, with the upper 1 / 2 slightly tilted backwards. On the lower wall of the front window, 5cm away from the window, 5 downward-bent pipes (wall thickness 0.6cm) made of 4cm diameter lead faucets are installed, and the spacing is determined according to needs. They are channels for various lines; plastic tubes connected to syringes also pass through them.

7. Technical solution for producing handheld injection needles: The needle stem is 0.7mm, 0.55mm, or thinner in various specifications; the length of the needle stem of each diameter (referring to the part far from the handle) is 10cm, 1.5cm, 20cm, and 25cm. Keep 2cm of the needle stem in front of the needle plug of the 14G injection needle, and cut off the needle stem far from it. The remaining 2cm needle stem is covered with the proximal end of the hard plastic tube, so that the plastic tube is connected to the syringe barrel with the help of the needle plug of the 14G injection needle; 2cm away from each injection needle stem, use a soft stainless steel wire with a diameter of 0.15cm to tightly wrap a 3cm handle to the distal end. The 2cm needle stem on the handle is covered with the distal end of the hard plastic tube.

8. Design and produce technical solutions for mechanical handheld injection needles: the needle stem of each needle cover plastic tube and the handle junction are bent at 90 degrees, and the rest of the parts are the same as the handheld needle.

9. Technical solution for producing an intelligent robot for injecting hypertonic NaCl solution to treat malignant tumors (design concept: practical and low-cost): Mechanical system: It has a human-like head shell, neck and neck joint (can bend 50 degrees, turn 35 degrees left and right), chest cavity, upper limbs on both sides, and the range of motion is similar to that of human upper limbs (the flexibility of the robot's joints mainly depends on sufficient actuators: there are 6 rotary actuators on the shoulder, 2 linear actuators and 2 rotary actuators on the elbow, 4 linear actuators on the wrist, and 2 rotary actuators on the waist. Each hand has 22 degrees of freedom; force sensors are installed on the fingertips...). Abdominal cavity; waist and waist joint: forward, can bend 45 degrees, move 30 degrees left and right, and the lower limbs are short in front and back and wide in the shape of an elliptical cylinder. The top of the cylinder is connected to the abdominal cavity and welded above the feet. The feet are square cast iron of 50cm x 50cm x 20cm and weigh about 30kg. The four corners are polished to be round, and there are four controllable wheels at the bottom. The total height is 165cm. Drive system: The drive system enables the robot to move and perform various actions. It adopts electric drive system: stepper servo motor system. Control system: The core of the control system is the central processing unit (microprocessor), which receives information from sensors via the (input interface), processes and judges data, makes decisions, and issues instructions via the (output interface) to control the behavior of the robot. Modern microprocessors are highly integrated, usually integrated on a semiconductor chip. The compiled program is copied to the program memory of the main controller through the USB interface. The main controller issues commands (in the form of pulses or potentials) according to certain logical operation requirements to control the coordinated work of the three parts of the computer: input, operation, and output. Perception system: The perception system collects environmental information through various sensors to help the robot make the right response. Sensors: Visual sensors (two cameras), auditory sensors (two microphones), and tactile sensors (there must be a sufficient number of tactile sensors on fingers, palms, and wrists) are required. It can perceive information in the environment and convert this information into electrical signals, which are then converted into digital signals through D / A and transmitted to the control system for the controller to process and judge data and issue instructions. The accuracy and stability of the sensor must be good, and its performance directly affects the performance of the automation equipment. Actuator: It is the power output component of the automation equipment. It drives the mechanical parts to move according to the instructions of the controller. The type and performance of the actuator are closely related to the purpose of the automation equipment. You can consider using a suitable type of sensor and actuator integrated equipment, which has many advantages. Robot actuators usually include motors, reducers, encoders, controllers and other devices. Programming: Automatic programming machines (programming technology is developing rapidly, and more intelligent technology equipment will be available by then) use binary 0 and 1 codes to program, and then copy the program to the program memory of the main controller after repeated modification on the computer. Binary 0 and 1 codes have many advantages, such as high efficiency, which is better than assembly language. Since there are no two completely identical things in the world, the location, size, and shape of lung malignant tumors vary in different cases, so the program should be divided into two parts: (1) routine activity program, and (2) treatment program for each case. The program for using the syringe must be written in detail, and the method of holding the syringe must be mastered by the intelligent robot: flexible and accurate. (1). Routine activity procedures: ①. Familiarize yourself with the working environment: get to know the operating table, tumor patients, anesthesiologists, digital X-ray machines (conventional, three-dimensional image digital X-ray machines), syringes, and the injection volume numbers displayed on the flow meter at the front of the syringe...; ②. Learn to use digital X-ray machines, three-dimensional image digital X-ray machines, and learn to read the conditions of malignant tumors and marginal areas on the display screen; learn to identify images of malignant tumors and non-tumor tissues; ③. Learn to identify the position of the human chest: left chest, right chest, sternum, ribs, intercostal space, distance from the midclavicular line, anterior axillary line, midaxillary line, etc. to the inside and outside (? cm)... The above-written programs are placed in the program storage of the main controller. (2) Each case of lung malignant tumor needs a treatment program: peripheral lung cancer and metastatic malignant tumors of the lung (multiple malignant metastatic malignant tumors should be numbered 1, 2, 3...) The size, shape, and location of each tumor are obtained during CT examination. On this basis, the doctor makes a complete treatment plan for each malignant tumor patient. The programmer uses an automatic programming machine to program the treatment program in 0 and 1 codes and save it in a USB flash drive. When using it, download the program in the USB flash drive to the computer through the USB port, and then copy and paste the program in the computer through the computer's file manager to copy the program in the program memory of the intelligent robot's main controller to execute the new treatment program. Export it after use. Power supply: Intelligent power supply adopts DSP digital control technology, with high precision, low ripple, fast response, good high-voltage output stability, and can be used in parallel and series. It is a bit complicated and cumbersome... You can consider making a simple and practical choice. * In order to reduce costs, the human-computer dialogue device was omitted and the treatment program writing was made more detailed. When practice proved that it was not feasible, human-computer dialogue was added.