Plasma activated gas wound treatment device and method

Abstract

The application discloses a kind of plasma activated gas wound treatment device and method, the method includes: plasma generator, treatment chamber, high voltage power module, air pump and control module, wherein, treatment chamber includes back gas passage and gas supply passage, back gas passage is communicated with the air inlet of the plasma generator by air pump, and the gas supply passage is communicated with the air outlet of the plasma generator;High voltage power module is electrically connected with the plasma generator and the control module respectively, control module controls the on-off of the high voltage power module, and then controls the plasma generator to be in intermittent working state or continuous working state, the plasma generator generates first type plasma activated gas in intermittent working state, and generates second type plasma activated gas in continuous working state;The application enhances the treatment effect of plasma activated gas, improves the utilization rate of active particles, meets the needs of efficient disinfection and promotes wound healing.

Description

TECHNICAL FIELD

[0001] The application belongs to the technical field of plasma biomedical technology, and particularly relates to a plasma activated gas wound treatment device and method. BACKGROUND

[0002] Trauma is often caused by traffic accidents, sharp instrument injuries, surgery, etc., and poses a serious threat to human health. Trauma treatment generally includes debridement, disinfection, hemostasis, and promotion of healing, etc. However, the current main drug therapy has problems such as single function, poor broad-spectrum bactericidal property, and easy drug resistance, etc., and is difficult to fully meet the treatment needs of patients. Therefore, it is particularly important to develop a new type of multifunctional integrated trauma treatment technology. In recent years, atmospheric pressure cold plasma (hereinafter referred to as plasma) has shown great application potential in the field of trauma treatment. The active gas (hereinafter referred to as plasma activated gas) generated by plasma excitation contains a large amount of active oxygen particles (ROS) and active nitrogen particles (RNS) with biomedical effects, such as O3, NO, N2O5, etc., which can induce tissue regeneration and efficiently inactivate a variety of pathogenic microorganisms at an appropriate dose, and microorganisms are difficult to develop drug resistance. In addition, the temperature of plasma activated gas is close to room temperature, and it can be used to act on complex wound sites in a large range and without dead angles by virtue of the diffusivity of gas.

[0003] The existing discharge plasma equipment usually uses rare gases such as He and Ar as working gas, which not only has high cost, but also needs to be equipped with a gas cylinder, resulting in a large equipment volume. Air discharge plasma uses air as working gas, which can be obtained locally and can realize the economic and efficient generation of plasma activated gas rich in ROS and RNS. However, air discharge has three distinct product modes: ozone mode dominated by O3, nitrogen oxide mode dominated by NO, and transition mode in which O3 and NO coexist when the two modes are converted to each other. High-valence nitrogen oxides such as N2O5 are only generated in the transition mode, making the transition mode have higher microbial inactivation efficiency than the other two modes, and NO in the nitrogen oxide mode plays a crucial role in cell proliferation, migration, differentiation, and apoptosis during wound healing. However, air plasma is extremely sensitive to discharge conditions, making it difficult to stably maintain the transition mode and easily convert to the nitrogen oxide mode, making it difficult to meet the long-term high-efficiency sterilization needs. In addition, the leakage of O3 and nitrogen oxides can also cause potential harm to human health and the environment, which may affect the treatment effect and reduce the acceptance of medical workers and patients. SUMMARY

[0004] (I) Invention purposes

[0005] The application aims to provide a plasma activated gas wound treatment device and method, which adjusts the active species and concentration in the internal circulation activated gas by controlling the intermittent or continuous working state of the plasma activated gas generator, enhances the treatment effect of the plasma activated gas, improves the utilization rate of active particles, and meets the needs of efficient disinfection and wound healing promotion.

[0006] (II) Technical solutions

[0007] To solve the above problems, the first aspect of the application provides a plasma activated gas wound treatment device, comprising: a plasma generator, a treatment chamber, a high-voltage power supply module, a gas pump and a control module, wherein,

[0008] The treatment chamber comprises a gas return passage and a gas supply passage, the gas return passage is communicated with the gas inlet of the plasma generator through the gas pump, and the gas supply passage is communicated with the gas outlet of the plasma generator, and the plasma generator and the gas pump are arranged outside the treatment chamber;

[0009] The high-voltage power supply module is electrically connected with the plasma generator and the control module respectively, and the control module controls the plasma generator to be in an intermittent working state or a continuous working state by controlling the on-off of the high-voltage power supply module.

[0010] The plasma generator generates a first type of plasma activated gas in the intermittent working state, the first type of plasma activated gas comprises O3 and N2O5, and is used for disinfecting the treatment site in the treatment chamber;

[0011] The plasma generator generates a second type of plasma activated gas in the continuous working state, the second type of plasma activated gas comprises NO, and is used for promoting the healing of the treatment site in the treatment chamber.

[0012] Further, the intermittent working state comprises: in a first time period, the plasma generator simultaneously performs discharge and flows working gas, and in a second time period, the plasma generator stops discharging while flowing working gas, and the first time period and the second time period are sequentially connected and reciprocally circulated.

[0013] Further, the continuous working state comprises: the plasma generator simultaneously performs discharge and flows working gas.

[0014] Further, the wound treatment device further comprises a temperature adjusting module and a flow rate adjusting module, and the control module is electrically connected with the temperature adjusting module and the flow rate adjusting module respectively.

[0015] Further, the temperature adjusting module comprises a refrigeration device and a temperature raising device, when the plasma generator is switched from the intermittent working state to the continuous working state, the control module starts the temperature raising device to raise the temperature of the environment around the plasma generator; when the plasma generator is switched from the continuous working state to the intermittent working state, the control module starts the refrigeration device to lower the temperature of the environment around the plasma generator.

[0016] Further, when the plasma generator is switched from the intermittent working state to the continuous working state, the control module controls the flow rate adjusting module to lower the flow rate of the air pump, when the plasma generator is switched from the continuous working state to the intermittent working state, the control module controls the flow rate adjusting module to increase the flow rate of the air pump.

[0017] Further, the treatment chamber further comprises a three-way valve, which is arranged between the air return passage and the air pump.

[0018] Further, the three-way valve is provided with a suspended end, the suspended end is introduced with working gas outside the treatment chamber, comprising:

[0019] During the treatment process, the plasma generator is turned on, the suspended end is turned on, and the air pump inhales working gas while recycling plasma activated gas, the treatment process comprises the intermittent working state and the continuous working state of the plasma generator;

[0020] When the treatment is completed, the plasma generator is turned off, the suspended end is turned off, and the air pump only recycles plasma activated gas.

[0021] Further, the total content of O3 and N2O5 accounts for more than 55% of the total concentration of active substances in the first type of plasma activated gas, and the content of NO accounts for more than 35% of the total concentration of active substances in the second type of plasma activated gas.

[0022] Another aspect of the present application also provides a treatment method of a wound treatment device using plasma activated gas, the method uses any one of the wound treatment devices using plasma activated gas described above for treatment, and the method comprises:

[0023] The plasma generator is set to the intermittent working state, the suspended end of the three-way valve is turned on, the first type of plasma activated gas is generated, the first type of plasma activated gas is input into the treatment chamber through the air supply passage to disinfect the part to be treated, and at the same time, the plasma activated gas is recycled through the air return passage, the intermittent working state runs for 0-30 minutes, wherein the first type of plasma activated gas comprises O3 and N2O5.

[0024] After the intermittent operation ends, the plasma generator is switched to continuous operation, the suspended end of the three-way valve is opened, the second type of plasma activated gas is generated, the second type of plasma activated gas is input into the treatment chamber through the gas supply passage to promote the healing of the treatment site, and the plasma activated gas is recovered through the gas return passage, the continuous operation time is 0-30 minutes, and the second type of plasma activated gas comprises NO.

[0025] After the continuous operation ends, the suspended end of the three-way valve is closed, and the plasma generator 300 is turned off, and the treatment ends.

[0026] (III) Beneficial effects

[0027] The application provides a plasma activated gas wound treatment device and method. The device adopts an internal circulation mode controlled in time division, recycles generated plasma activated gas and further activates the plasma activated gas as working gas, can avoid the harm caused by O3 and nitrogen oxide leakage, and can improve the concentration and generation efficiency of active particles. In addition, the internal circulation continuous operation can gradually increase the concentration of nitrogen oxides in the activated gas, thereby greatly reducing the yield of high-valence nitrogen oxides and weakening the disinfection and sterilization capacity of the plasma activated gas. The application adjusts the concentration of nitrogen oxides in the internal circulation activated gas by controlling the intermittent or continuous operation of the plasma activated gas generator, and adjusts the temperature and flow rate of the working environment and the working gas flow rate by using a temperature and flow rate adjustment module, so that the stable conversion of the transition mode and the nitrogen oxide mode of the plasma activated gas generator is realized. The high-valence nitrogen oxides generated in the transition mode can kill bacteria in the wound, and the NO generated in the nitrogen oxide mode can promote wound healing, so that a treatment method for efficient disinfection and wound healing is developed. The specific principle is that the control module controls the plasma generator to be in an intermittent operation state or a continuous operation state, the plasma generator generates a first type of plasma activated gas containing O3 and N2O5 in the intermittent operation state, and the first type of plasma activated gas is used for disinfection of a treatment site. The plasma generator generates a second type of plasma activated gas containing NO in the continuous operation state, and the second type of plasma activated gas is used for promoting healing of the treatment site. The first type of plasma activated gas and the second type of plasma activated gas enter the gas supply passage of the treatment chamber through the gas outlet of the plasma generator and act on the treatment site. During the treatment process, the plasma generator is switched to the intermittent operation state or the continuous operation state, so that the treatment effect of the plasma activated gas is enhanced, the utilization rate of active particles is improved, and the demand for efficient disinfection and wound healing is met. The treatment chamber comprises a gas return passage. The internal circulation gas circuit recycles the plasma activated gas treated on the wound in the treatment chamber, can avoid a large amount of gas and active particles from diffusing into the atmosphere, and can reduce potential harm to human health and the environment. BRIEF DESCRIPTION OF DRAWINGS

[0028] Figure 1 is a schematic diagram of the overall structure of a plasma-activated gas wound treatment device according to the present application;

[0029] Figure 2 is a schematic diagram of a partial structure of a plasma-activated gas wound treatment device according to the present application (a schematic diagram of the connection between the circuit and the gas path among the air pump, the plasma-activated gas generator, and the treatment chamber);

[0030] Figure 3 is a graph showing the sterilization effect of Staphylococcus aureus using the plasma-activated gas wound treatment method according to the present application.

[0031] Reference signs:

[0032] 100, air pump; 200, high-voltage power module; 300, plasma generator (plasma-activated gas generator); 310, outer ring electrode; 320, inner ring electrode; 330, quartz dielectric layer; 340, heat sink; 400, treatment chamber; 410, air supply path; 420, air return path; 421, disposable filter structure; 430, input end; 440, output end; 450, three-way valve; 500, temperature adjustment module; 600, flow rate adjustment module; 700, control module. DETAILED DESCRIPTION

[0033] In order to make the objectives, technical solutions, and advantages of the present application clearer and more comprehensible, the present application is further described in detail below with reference to the specific embodiments and the accompanying drawings. It should be understood that these descriptions are merely exemplary and are not intended to limit the scope of the present application. In addition, in the following description, the description of well-known structures and techniques is omitted to avoid unnecessary confusion of the concept of the present application.

[0034] As shown in Figure 1 , the present application provides a plasma-activated gas wound treatment device, which comprises a plasma generator 300, a treatment chamber 400, a high-voltage power module 200, an air pump 100, and a control module 700, wherein:

[0035] The treatment chamber 400 comprises a gas supply passage 410 and a gas return passage 420, the plasma generator 300 and the gas pump 100 are arranged outside the treatment chamber 400, the gas return passage 420 is communicated with the gas inlet of the plasma generator 300 through the gas pump 100, and the gas supply passage 410 is communicated with the gas outlet of the plasma generator 300; the treatment chamber 400 has good airtightness, and the treatment chamber can be made of a gas-impermeable rigid material such as acrylic material, or a soft gas-impermeable flexible high polymer material such as a plastic bag, preferably a plastic bag, the treatment chamber separates the internal equipment and the external instrument by a bagging mode, the treatment chamber 400 delivers the plasma-activated gas generated by the plasma generator 300 to the treatment site through the gas supply passage 410, and recovers the plasma-activated gas in the treatment chamber 400 through the gas return passage 420, and the treatment site includes but is not limited to the foot, the hand, the groin and the like. The discharge form of the plasma generator 300 includes but is not limited to corona discharge and dielectric barrier discharge, and the discharge structure includes but is not limited to a needle-cylinder structure and a dielectric barrier structure. The gas return passage 420 is further provided with a disposable filter structure 421 for filtering out impurities such as effusion, scab and skin tissue at the wound site.

[0036] Further, the input end 430 and the output end 440 can be arranged in the treatment chamber 400, one end of the gas supply passage 410 is connected with the gas outlet of the plasma generator 300, and the other end is connected with the input end 430, the generated plasma-activated gas can be further delivered to the treatment site through the input end 430, one end of the gas return passage 420 is communicated with the gas pump 100, and the other end is connected with the output end 440, that is, the plasma-activated gas in the treatment chamber is recovered through the output end 440 and then enters the gas return passage 420.

[0037] The treatment chamber 400 further comprises a three-way valve 450, which is arranged inside the treatment chamber 400 and between the gas return passage 420 and the gas pump 100. The common end of the three-way valve 450 is connected with the gas inlet of the gas pump 100, and the other two ends are connected with the gas return passage 420 for recovering the plasma-activated gas in the treatment chamber 400, and the other end is a suspended end, the suspended end adjusts the gas pressure in the treatment chamber 400 by introducing working gas outside the treatment chamber 400, including the treatment process and the non-treatment process, as follows:

[0038] During the treatment process, the plasma generator 300 is turned on, the suspended end is opened, and the gas pump 100 inhales the working gas while recovering the plasma-activated gas, and the treatment process includes an intermittent working state and a continuous working state of the plasma generator 300;

[0039] When the treatment is over (off-treatment), the plasma generator 300 is switched off, the hanging end is closed, and the gas pump 100 recovers only the plasma-activated gas.

[0040] As Figure 1As shown, the high-voltage power module 200 is electrically connected with the plasma generator 300 and the control module 700, respectively. The control module 700 includes a control panel and internal control circuit, which is used for selection and control of the working mode of the device and the working state of each part. The types of the high-voltage power module 200 include but are not limited to AC sinusoidal high-voltage power supply, pulse high-voltage power supply, DC high-voltage power supply, etc. The control module 700 controls the high-voltage power module 200 to be on or off, thereby controlling the plasma generator 300 to be in intermittent working state or continuous working state. There are five buttons on the device panel of the control module: disinfection mode, healing promotion mode, start / stop, + and -. The disinfection mode corresponds to the intermittent working state of the plasma generator 300, the healing promotion mode corresponds to the continuous working state of the plasma generator 300, and + and - are used to set the processing time. Before starting the device, the working time of the two modes is set respectively. After the setting is completed, press the "start / stop" button to start the device. By default, the disinfection mode is performed first, and then the healing promotion mode is performed. The plasma generator 300 generates the first type of plasma activated gas in the intermittent working state, and the first type of plasma activated gas is used for disinfection of the treatment site in the treatment chamber 400. The intermittent working state includes: in the first time period, the plasma generator 300 discharges and circulates working gas at the same time, in the second time period, the plasma generator 300 stops discharging and circulates working gas, and the first time period and the second time period are connected in turn and cycle repeatedly. The principle of setting the intermittent working state of the device is as follows: when the air discharge is in continuous working state, the concentration of nitrogen oxides in the treatment chamber gradually increases, resulting in the gradual disappearance of ozone and N2O5. Therefore, in the intermittent working state, the discharge is stopped after a period of time, and the working gas is circulated to reduce the concentration of nitrogen oxides in the treatment chamber, so that it returns to the state before discharging, and then the discharge is restarted to generate ozone and N2O5. In this intermittent state, the first time period is set to, for example, 45s, and the second time period is set to, for example, 30s. The reason for such setting is that when the gas phase product of the device is measured by a Fourier infrared spectrometer (FTIR), the key gas product N2O5 for disinfection function disappears at most when working for 45s, and the shortest rest time required for generating the same amount of gas again is 30s. However, the running time and the time of stopping discharge will change according to the changes of temperature and humidity, for example, the running time will be prolonged and the time of stopping discharge will be shortened when the temperature decreases. The first type of plasma activated gas includes O3 and N2O5, which have disinfection function. O3 and N2O5 belong to active substances, and the total content of O3 and N2O5 accounts for more than 55%, for example, 60%, of the total concentration of active substances in the first type of plasma activated gas.

[0041] The plasma generator 300 generates the second type of plasma activated gas in a continuous working state, which is used to promote healing of the treatment site in the treatment chamber 400. The continuous working state includes discharging and circulating working gas in the plasma generator 300. The second type of plasma activated gas includes NO with a healing-promoting function, which is an active substance and accounts for more than 35%, for example 40%, of the total concentration of active substances in the second type of plasma activated gas.

[0042] Further, the wound treatment device further comprises a temperature adjusting module 500 and a flow rate adjusting module 600, and the control module 700 is electrically connected to the temperature adjusting module 500 and the flow rate adjusting module 600, respectively. The plasma activated gas wound treatment device of the present application adopts a time-sharing control mechanism, so that it works in an intermittent or continuous mode according to the needs, and cooperates with the temperature adjusting module 500 and the flow rate adjusting module 600 to realize stable conversion between different working modes. The temperature adjusting module 500 comprises a refrigeration device and a heating device, and the refrigeration device comprises a semiconductor refrigeration sheet, a water cooling module and a cooling fan. When the plasma generator 300 is switched from the intermittent working state to the continuous working state, the control module 700 starts the heating device to warm the environment around the plasma generator 300. The design principle here is that if the treatment only needs the disinfection mode (intermittent working state), a low-temperature environment is advantageous, but if the healing-promoting mode (continuous working state) is needed at this time, the temperature is too low to quickly switch the mode. At this time, the temperature adjusting module needs to be warmed to make the environment around the plasma generator 300 a local high-temperature environment to promote the mode conversion process. Similarly, when the plasma generator 300 is switched from the continuous working state to the intermittent working state, the control module 700 starts the refrigeration device to cool the environment around the plasma generator 300, that is, if the treatment only needs the healing-promoting mode, a high-temperature environment is advantageous, and if the disinfection mode is needed, the temperature adjusting module needs to start the cooling fan or the refrigeration sheet to form a local low-temperature environment around the plasma generator 300. In the present application, the temperature adjusting module sets an optimal working temperature, for example 27℃, and adjusts based on this optimal working temperature, so that the working temperature inside the device is always maintained near the optimal working temperature.

[0043] Furthermore, when the plasma generator 300 switches from intermittent to continuous operation, the control module 700 controls the flow rate adjustment module 600 to reduce the flow rate of the air pump 100 to ensure that the NO production remains constant. This step, combining temperature and flow rate adjustment, also helps to stabilize the product type and yield. Similarly, when the plasma generator 300 switches from continuous to intermittent operation, the control module 700 controls the flow rate adjustment module 600 to increase the flow rate of the air pump 100 to ensure that the N2O5 production remains constant.

[0044] like Figure 2 As shown, the plasma generator 300 discharges in the form of a micro-gap coaxial annular dielectric barrier discharge, which includes: an outer ring electrode 310, an inner ring electrode 320, a quartz dielectric layer 330, a heat sink 340, an air inlet, and an air outlet. The inner wall of the outer ring electrode 310 is fixed with a quartz dielectric layer 330, and air introduced between the quartz dielectric layer 330 and the inner ring electrode 320 is ionized into plasma. The outer ring electrode 310 is grounded, and the inner ring electrode 320 is connected to a voltage of AC 13kV. The gap (discharge gap) between the inner ring electrode 320 and the quartz dielectric layer 330 is 0.4mm, the thickness of the quartz dielectric layer 330 is 1.6mm, and the length of the discharge region is 110mm. Air is introduced through the air inlet, and the discharge generates plasma activation gas with disinfection or healing functions, which is then introduced into the treatment chamber 400 to treat the affected area. The air pump 100 uses ambient air, has a rated voltage of 24V, and a maximum gas flow rate of 11.5L / min.

[0045] Another aspect of the present invention provides a method for treating injuries using any of the plasma-activated gas trauma treatment devices described above, the method comprising the following steps:

[0046] S1. Set the plasma generator 300 to intermittent operation mode, open the floating end of the three-way valve 450 to generate first type of plasma activation gas, the first type of plasma activation gas is input into the treatment chamber 400 through the gas supply passage 410 to disinfect the treatment site, and at the same time the plasma activation gas is recovered through the return gas passage 420. The intermittent operation mode runs for 0-30 minutes (this mode is not run when the running time is 0), wherein the first type of plasma activation gas includes O3 and N2O5;

[0047] S2, after the intermittent operation state ends, the plasma generator 300 is switched to a continuous operation state, the idle end of the three-way valve 450 is opened, the second type of plasma activated gas is generated, the second type of plasma activated gas is input into the treatment chamber 400 through the gas supply passage 410, and the wound healing of the treatment site is promoted, and at the same time, the plasma activated gas is recovered through the gas return passage 420, the continuous operation state runs for 0-30 minutes (when the running time is 0, the mode is not run, that is, the intermittent operation state and the continuous operation state are not selected at the same time, and when the running time is 0, the continuous operation state can be selected), wherein the second type of plasma activated gas comprises NO;

[0048] S3, after the continuous operation state ends, the idle end of the three-way valve 450 is closed, the plasma generator 300 is closed, the air pump runs for 3-5 minutes, and then the plasma activated gas wound treatment device stops running, and the treatment ends.

[0049] The steps S1, S2 and S3 are repeated to perform the next treatment cycle. During the treatment, when the plasma generator 300 is switched from the intermittent operation state to the continuous operation state, the control module 700 starts the heating device to heat the environment around the plasma generator 300, and at the same time, the control module 700 reduces the flow rate of the air pump 100 through the flow rate adjustment module 600 to ensure that the yield of NO is unchanged; when the plasma generator 300 is switched from the continuous operation state to the intermittent operation state, the control module 700 starts the refrigeration device to cool the environment around the plasma generator 300, and at the same time, the control module 700 controls the flow rate adjustment module 600 to increase the flow rate of the air pump 100 to ensure that the yield of N2O5 is unchanged.

[0050] The following will be described in combination with Figure 3 The sterilization effect of the plasma activated gas wound treatment method of the present application on Staphylococcus aureus is described below, and the treatment method is specifically as follows:

[0051] The Staphylococcus aureus solution with a volume of 200 μL, OD 600 about 1 is placed in the treatment chamber 400, the internal circulation plasma activated gas wound treatment device is turned on, and the gas blowing treatment is performed in the disinfection mode (intermittent operation state), and the treatment time is 5 min, 10 min and 20 min, respectively. It can be found through the determination of the number of Staphylococcus aureus in the solution that when the treatment time is 5 min, the device has a sterilization effect of one order of magnitude on the bacterial solution; when the treatment time is 10 min, the device has a sterilization effect of three orders of magnitude on the bacterial solution; and when the treatment time is 20 min, the bacteria can be completely killed.

[0052] The application relates to a plasma-activated gas wound treatment device and method, which adopts an internal circulation design, introduces plasma-activated gas from a gas supply channel, an input end into a treatment chamber for treatment, and recycles and reuses the plasma-activated gas through an output end and a gas return channel, a three-way valve arranged in the treatment chamber adjusts the air pressure of the treatment chamber by opening and closing a suspended end, so as to promote the penetration and absorption of active particles; the application also carries out time-sharing regulation and control on a plasma-activated gas generator, so that the plasma-activated gas generator works in an intermittent or continuous mode according to requirements, and realizes stable conversion between different working modes by cooperating with a temperature adjusting module and a flow rate adjusting module: the plasma-activated gas generated in the intermittent working mode is rich in O3 and N2O5, and can efficiently sterilize and disinfect; and the plasma-activated gas generated in the continuous working mode is rich in NO, and is helpful to promote wound healing. The application realizes the integration of efficient sterilization and healing promotion functions, avoids potential hazards of O3 and nitrogen oxides leakage to human health and the environment, and has the following advantages:

[0053] 1. The internal circulation gas channel design formed by the gas supply channel, the gas return channel and the like in the treatment chamber can recycle the plasma-activated gas processed by the wound in the treatment chamber, which is helpful to enhance the treatment effect of the plasma-activated gas, improve the utilization rate of active particles, and effectively avoid the diffusion of the gas and active particles to the atmosphere, so as to reduce the potential influence on patients, medical workers and the environment.

[0054] 2. By controlling the intermittent or continuous working of the plasma-activated gas generator, the conversion of the plasma-activated gas generator between a sterilization mode (transition mode) and a healing promotion mode (nitrogen oxide mode) is realized, wherein the intermittent working of the plasma-activated gas generator solves the problem that the continuous working of the internal circulation causes the transition mode to be rapidly converted into the nitrogen oxide mode, and the continuous working of the plasma-activated gas generator is in the nitrogen oxide mode.

[0055] 3. The temperature adjusting module can adjust the working environment temperature, so that the device can ensure that the healing promotion mode is rapidly converted into the nitrogen oxide mode and stably works in the nitrogen oxide mode through temperature rising in a low-temperature environment, and ensure that the sterilization mode stably works in the transition mode through temperature reduction in a high-temperature environment, thereby offsetting the influence of the environment temperature on the device and enhancing the working stability and environmental adaptability of the device.

[0056] 4. The application realizes the free conversion of the discharge mode by using only a single plasma-activated gas generator, reduces the device size, reduces the production cost, and uses air as the working gas, so that the device has portability.

[0057] It should be understood that the foregoing detailed description of the application, rather than limiting the application, is intended to explain and describe the current implementation of the application. Therefore, any modification, equivalent replacement or improvement made without departing from the spirit and scope of the application should be included in the protection scope of the application. In addition, the appended claims of the application are intended to cover all changes and modifications falling within the scope and boundary of the appended claims, or the equivalent form of such scope and boundary.

Claims

1. A plasma-activated air wound treatment device, characterized in that, The wound treatment device comprises a plasma generator (300), a treatment chamber (400), a high-voltage power supply module (200), a gas pump (100) and a control module (700), wherein, The treatment chamber (400) comprises a gas supply passage (410) and a gas return passage (420), the gas return passage (420) is communicated with the gas inlet of the plasma generator (300) through the gas pump (100), the gas supply passage (410) is communicated with the gas outlet of the plasma generator (300), and the plasma generator (300) and the gas pump (100) are arranged outside the treatment chamber (400); The high-voltage power supply module (200) is electrically connected with the plasma generator (300) and the control module (700) respectively, the control module (700) controls the high-voltage power supply module (200) to be on or off, so as to control the plasma generator (300) to be in an intermittent working state or a continuous working state; wherein the intermittent working state comprises that in a first time period, the plasma generator (300) discharges and circulates working gas at the same time, in a second time period, the plasma generator (300) stops discharging while circulating working gas, and the first time period and the second time period are connected in turn and reciprocate; the continuous working state comprises that the plasma generator (300) discharges and circulates working gas at the same time; The plasma generator (300) generates a first type of plasma activated gas in the intermittent working state, the first type of plasma activated gas comprises O3 and N2O5, and is used for disinfecting a to-be-treated part in the treatment chamber (400); the content sum of O3 and N2O5 accounts for more than 55% of the total concentration of active substances in the first type of plasma activated gas; The plasma generator (300) generates a second type of plasma activated gas in the continuous working state, the second type of plasma activated gas comprises NO, and is used for promoting healing of the to-be-treated part in the treatment chamber (400); the content of NO accounts for more than 35% of the total concentration of active substances in the second type of plasma activated gas; The wound treatment device further comprises a temperature adjusting module (500) and a flow rate adjusting module (600), and the control module (700) is electrically connected with the temperature adjusting module (500) and the flow rate adjusting module (600) respectively. The temperature adjusting module (500) comprises a refrigeration device and a temperature rising device, when the plasma generator (300) is switched from the intermittent working state to the continuous working state, the control module (700) starts the temperature rising device to warm the environment around the plasma generator (300); when the plasma generator (300) is switched from the continuous working state to the intermittent working state, the control module (700) starts the refrigeration device to cool the environment around the plasma generator (300).

2. The plasma-activated gas wound treatment device of claim 1, wherein, ​ 3. The plasma-activated gas wound treatment apparatus of claim 1, wherein, When the plasma generator (300) is switched from the intermittent working state to the continuous working state, the control module (700) controls the flow rate adjusting module (600) to reduce the flow rate of the gas pump (100), and when the plasma generator (300) is switched from the continuous working state to the intermittent working state, the control module (700) controls the flow rate adjusting module (600) to increase the flow rate of the gas pump (100).

4. The plasma-activated gas wound treatment apparatus of claim 1, wherein, The treatment chamber (400) further comprises a three-way valve (450) arranged between the gas return passage (420) and the gas pump (100).

5. The plasma-activated gas wound treatment apparatus of claim 4, wherein, The three-way valve (450) is provided with a suspended end, which adjusts the gas pressure in the treatment chamber (400) by introducing working gas outside the treatment chamber (400), comprising: During the treatment process, the plasma generator (300) is turned on, the suspended end is turned on, and the gas pump (100) inhales working gas while recovering plasma activated gas, and the treatment process includes the intermittent working state and the continuous working state of the plasma generator (300); When the treatment is completed, the plasma generator (300) is turned off, the suspended end is turned off, and the gas pump (100) only recovers plasma activated gas.

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