Synthesis of 5-chloro-2,4-diphenylpyrimidine
The improved synthesis method solves the problems of numerous steps, high cost, and low purity in the synthesis of 5-chloro-2,4-diphenylpyrimidine in the existing technology, and realizes the preparation of 5-chloro-2,4-diphenylpyrimidine in a high-efficiency and economical way, thereby improving the performance of organic electronic devices.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- NATAORGANIC MATERIAL (SUZHOU) CO LTD
- Filing Date
- 2024-12-13
- Publication Date
- 2026-05-12
AI Technical Summary
Existing methods for synthesizing 5-chloro-2,4-diphenylpyrimidine involve numerous steps, are complex to operate, are costly, and produce products with low purity. In particular, the synthesis efficiency is low due to problems such as excessive reaction and selective coupling.
5-Amino-2,4-diphenylpyrimidine is prepared by adding acid and nitrite to a mixture of organic solvent and water to form a reaction system, and then adding it dropwise to an acidic salt solution of chloride for reaction. Alternatively, 5-amino-2,4-dichloropyrimidine is prepared by reacting 5-amino-2,4-dichloropyrimidine with phenylboronic acid, potassium carbonate and palladium dichloride of bis(triphenylphosphine) in a mixture of organic solvent and water.
It significantly improved the yield and purity of 5-chloro-2,4-diphenylpyrimidine, optimized the performance of organic electronic devices constructed using organic light-emitting technology, and reduced production costs.
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Figure CN119569659B_ABST
Abstract
Description
Technical Field
[0001] This invention relates to the field of organic chemistry, and specifically discloses a method for synthesizing 5-chloro-2,4-diphenylpyrimidine. Background Technology
[0002] Organic light emission (OLED) is a phenomenon that utilizes organic materials to efficiently convert electrical energy into light energy. OLED technology is an electro-luminescent technology that uses organic materials to release energy through the recombination of electrons and holes under an external electric field, radiating it as light. It features simple fabrication, low cost, high luminous efficiency, and good flexibility, and is widely used in displays, lighting, and optoelectronics. Organic electronic devices constructed based on OLED technology have an ingenious structure comprising an anode, a cathode, and an organic material layer between them. These organic material layers are typically carefully selected from a series of specific compounds, which, as the core components of the organic layer, play a decisive role in the device's performance. For example, patents KR20190011463A and KR20180041482A detail innovative organic electronic devices in which a special compound is embedded within the organic layer, and 5-chloro-2,4-diphenylpyrimidine is an indispensable starting material for synthesizing this key compound.
[0003] However, current methods for synthesizing 5-chloro-2,4-diphenylpyrimidine have several drawbacks: numerous steps, complex operation, increased production difficulty and cost, and reliance on expensive raw materials. For example, although patent KR2016065298 reports a synthetic route, this method is plagued by problems of over-reaction and selective coupling, resulting in low product purity and low synthetic efficiency.
[0004] In view of the shortcomings of the existing technology, the present invention aims to develop a new, more efficient, economical and simple synthetic method to improve the yield and purity of 5-chloro-2,4-diphenylpyrimidine. Summary of the Invention
[0005] To address the above problems, the first aspect of this invention provides a method for synthesizing 5-chloro-2,4-diphenylpyrimidine, as follows:
[0006] 5-Amino-2,4-diphenylpyrimidine was dissolved in a mixture of organic solvent and water, acid was added, the mixture was stirred, the temperature was lowered, and then nitrite was added and stirred to form the first reaction system. Subsequently, it was added dropwise to an acidic salt solution of chloride to form the second reaction system, and the reaction was carried out to obtain 5-chloro-2,4-diphenylpyrimidine.
[0007]
[0008] In some specific embodiments of the first aspect, the amount of 5-amino-2,4-diphenylpyrimidine added per 1L of organic solvent is 505 to 910 mmol, preferably 505 mmol.
[0009] In some specific embodiments of the first aspect, the amount of 5-amino-2,4-diphenylpyrimidine added per 1L of organic solvent is 550 mmol; in some specific embodiments of the first aspect, the amount of 5-amino-2,4-diphenylpyrimidine added per 1L of organic solvent is 600 mmol; in some specific embodiments of the first aspect, the amount of 5-amino-2,4-diphenylpyrimidine added per 1L of organic solvent is 650 mmol; in some specific embodiments of the first aspect, the amount of 5-amino-2,4-diphenylpyrimidine added per 1L of organic solvent is 700 mmol. In some specific embodiments of the first aspect, the amount of 5-amino-2,4-diphenylpyrimidine added per 1L of organic solvent is 750 mmol; in some specific embodiments of the first aspect, the amount of 5-amino-2,4-diphenylpyrimidine added per 1L of organic solvent is 800 mmol; in some specific embodiments of the first aspect, the amount of 5-amino-2,4-diphenylpyrimidine added per 1L of organic solvent is 850 mmol; in some specific embodiments of the first aspect, the amount of 5-amino-2,4-diphenylpyrimidine added per 1L of organic solvent is 900 mmol.
[0010] In some specific embodiments of the first aspect, the amount of acid added per 1L of organic solvent is 2020 to 4040 mmol, preferably 2020 mmol.
[0011] In some specific embodiments of the first aspect, the amount of acid added per 1L of organic solvent is 2050 mmol; in some specific embodiments of the first aspect, the amount of acid added per 1L of organic solvent is 2100 mmol; in some specific embodiments of the first aspect, the amount of acid added per 1L of organic solvent is 2150 mmol; in some specific embodiments of the first aspect, the amount of acid added per 1L of organic solvent is 2200 mmol; in some specific embodiments of the first aspect, the amount of acid added per 1L of organic solvent is 2250 mmol; in some specific embodiments of the first aspect, the amount of acid added per 1L of organic solvent is 2300 mmol; in some specific embodiments of the first aspect, each 1L contains... The amount of acid added to the organic solvent is 2350 mmol; in some specific embodiments of the first aspect, the amount of acid added to each 1L of organic solvent is 2400 mmol; in some specific embodiments of the first aspect, the amount of acid added to each 1L of organic solvent is 2450 mmol; in some specific embodiments of the first aspect, the amount of acid added to each 1L of organic solvent is 2500 mmol; in some specific embodiments of the first aspect, the amount of acid added to each 1L of organic solvent is 2550 mmol; in some specific embodiments of the first aspect, the amount of acid added to each 1L of organic solvent is 2600 mmol; in some specific embodiments of the first aspect, the amount of acid added to each 1L of organic solvent is 2650 mmol. In some specific embodiments of the first aspect, the amount of acid added per 1L of organic solvent is 2700 mmol; in some specific embodiments of the first aspect, the amount of acid added per 1L of organic solvent is 2750 mmol; in some specific embodiments of the first aspect, the amount of acid added per 1L of organic solvent is 2800 mmol; in some specific embodiments of the first aspect, the amount of acid added per 1L of organic solvent is 2850 mmol; in some specific embodiments of the first aspect, the amount of acid added per 1L of organic solvent is 2900 mmol; in some specific embodiments of the first aspect, the amount of acid added per 1L of organic solvent is 2950 mmol; in some specific embodiments of the first aspect, the amount of acid added per 1L of organic solvent is... The amount of acid added to the organic solvent is 3000 mmol; in some specific embodiments of the first aspect, the amount of acid added to each 1L of organic solvent is 3050 mmol; in some specific embodiments of the first aspect, the amount of acid added to each 1L of organic solvent is 3100 mmol; in some specific embodiments of the first aspect, the amount of acid added to each 1L of organic solvent is 3150 mmol; in some specific embodiments of the first aspect, the amount of acid added to each 1L of organic solvent is 3200 mmol; in some specific embodiments of the first aspect, the amount of acid added to each 1L of organic solvent is 3250 mmol; in some specific embodiments of the first aspect, the amount of acid added to each 1L of organic solvent is 3300 mmol.In some specific embodiments of the first aspect, the amount of acid added per 1L of organic solvent is 3350 mmol; in some specific embodiments of the first aspect, the amount of acid added per 1L of organic solvent is 3400 mmol; in some specific embodiments of the first aspect, the amount of acid added per 1L of organic solvent is 3450 mmol; in some specific embodiments of the first aspect, the amount of acid added per 1L of organic solvent is 3500 mmol; in some specific embodiments of the first aspect, the amount of acid added per 1L of organic solvent is 3550 mmol; in some specific embodiments of the first aspect, the amount of acid added per 1L of organic solvent is 3600 mmol; in some specific embodiments of the first aspect, the amount of acid added per 1L of organic solvent is 3650 mmol. In some specific embodiments of the first aspect, the amount of acid added per 1L of organic solvent is 3700 mmol; in some specific embodiments of the first aspect, the amount of acid added per 1L of organic solvent is 3750 mmol; in some specific embodiments of the first aspect, the amount of acid added per 1L of organic solvent is 3800 mmol; in some specific embodiments of the first aspect, the amount of acid added per 1L of organic solvent is 3850 mmol; in some specific embodiments of the first aspect, the amount of acid added per 1L of organic solvent is 3900 mmol; in some specific embodiments of the first aspect, the amount of acid added per 1L of organic solvent is 3950 mmol; in some specific embodiments of the first aspect, the amount of acid added per 1L of organic solvent is 4000 mmol.
[0012] In some specific embodiments of the first aspect, the amount of nitrite added per 1L of the organic solvent is 555~1110mmol, preferably 555mmol.
[0013] In some specific embodiments of the first aspect, the amount of nitrite in each 1L of the organic solvent is 600 mmol; in some specific embodiments of the first aspect, the amount of nitrite in each 1L of the organic solvent is 650 mmol; in some specific embodiments of the first aspect, the amount of nitrite in each 1L of the organic solvent is 700 mmol; in some specific embodiments of the first aspect, the amount of nitrite in each 1L of the organic solvent is 750 mmol; in some specific embodiments of the first aspect, the amount of nitrite in each 1L of the organic solvent is 800 mmol; in some specific embodiments of the first aspect, the amount of nitrite in each 1L of the organic solvent is... The amount of nitrite in the solvent is 850 mmol; in some specific embodiments of the first aspect, the amount of nitrite in each 1L of the organic solvent is 900 mmol; in some specific embodiments of the first aspect, the amount of nitrite in each 1L of the organic solvent is 950 mmol; in some specific embodiments of the first aspect, the amount of nitrite in each 1L of the organic solvent is 1000 mmol; in some specific embodiments of the first aspect, the amount of nitrite in each 1L of the organic solvent is 1050 mmol; in some specific embodiments of the first aspect, the amount of nitrite in each 1L of the organic solvent is 1100 mmol.
[0014] In some specific embodiments of the first aspect, the molar ratio of 5-amino-2,4-diphenylpyrimidine to nitrite is (505~910):(555~1110).
[0015] In some specific embodiments of the first aspect, the molar ratio of 5-amino-2,4-diphenylpyrimidine to nitrite is 505:555.
[0016] In some specific embodiments of the first aspect, the molar ratio of the acid to the nitrite is (2020~4040):(555~1110).
[0017] In some specific embodiments of the first aspect, the molar ratio of the acid to the nitrite is 2020:555.
[0018] In some specific embodiments of the first aspect, the acid is selected from one or a mixture of hydrochloric acid, sulfuric acid, and nitric acid.
[0019] In some specific embodiments of the first aspect, the nitrite is sodium nitrite.
[0020] In some specific embodiments of the first aspect, the acidic salt solution of the chloride is an acidic cuprous chloride solution.
[0021] In some specific embodiments of the first aspect, the reaction temperature of the first reaction system is -10 to 0°C, preferably -5°C.
[0022] In some specific embodiments of the first aspect, the reaction temperature of the first reaction system is -10°C, -9°C, -8°C, -7°C, -6°C, -5°C, -4°C, -3°C, -2°C, -1°C, or 0°C.
[0023] In some specific embodiments of the first aspect, the reaction temperature of the second reaction system is 60–80°C, preferably 70°C.
[0024] In some specific embodiments of the first aspect, the reaction temperature of the second reaction system is 60°C, 61°C, 62°C, 63°C, 64°C, 65°C, 66°C, 67°C, 68°C, 69°C, 70°C, 71°C, 72°C, 73°C, 74°C, 75°C, 76°C, 77°C, 78°C, 79°C, or 80°C.
[0025] A second aspect of the present invention provides a method for synthesizing 5-amino-2,4-diphenylpyrimidine, as follows:
[0026] 5-Amino-2,4-dichloropyrimidine was reacted with phenylboronic acid, potassium carbonate, and palladium dichloride of bis(triphenylphosphine) in a mixture of organic solvent and water under an inert atmosphere to yield 5-amino-2,4-diphenylpyrimidine.
[0027]
[0028] In some specific embodiments of the second aspect, the molar amount of 5-amino-2,4-dichloropyrimidine in each 1L of the organic solvent is 142.5 to 162.5 mmol, preferably 152.5 mmol.
[0029] In some specific embodiments of the second aspect, the molar amount of 5-amino-2,4-dichloropyrimidine in each 1L of the organic solvent is 152.5 mmol.
[0030] In some specific embodiments of the second aspect, the molar amount of phenylboronic acid in each 1L of the organic solvent is 452.5 to 462.5 mmol, preferably 457.5 mmol.
[0031] In some specific embodiments of the second aspect, the molar amount of phenylboronic acid in each 1L of the organic solvent is 457.5 mmol.
[0032] In some specific embodiments of the second aspect, the molar amount of potassium carbonate in each 1L of the organic solvent is 452.5 to 462.5 mmol, preferably 457.5 mmol.
[0033] In some specific embodiments of the second aspect, the molar amount of potassium carbonate in each 1L of the organic solvent is 457.5 mmol.
[0034] In some specific embodiments of the second aspect, the molar amount of palladium dichloride bis(triphenylphosphine) in each 1L of the organic solvent is 2.5 to 3.5 mmol, preferably 3.0 mmol.
[0035] In some specific embodiments of the second aspect, the molar amount of palladium dichloride bis(triphenylphosphine) in each 1L of the organic solvent is 3.0 mmol.
[0036] In some specific embodiments of the second aspect, the molar ratio of 5-amino-2,4-dichloropyrimidine to phenylboronic acid is (142.5-162.5):(452.5-462.5).
[0037] In some specific embodiments of the second aspect, the molar ratio of 5-amino-2,4-dichloropyrimidine to phenylboronic acid is 152.5:457.5.
[0038] In some specific embodiments of the second aspect, the molar ratio of potassium carbonate to palladium dichloride bis(triphenylphosphine) is (452.5-462.5):(2.5-3.5).
[0039] In some specific embodiments of the second aspect, the molar ratio of potassium carbonate to palladium dichloride bis(triphenylphosphine) is 457.5:3.0.
[0040] In some specific embodiments of the second aspect, the organic solvent is selected from one or a mixture of DMF, toluene, xylene, acetonitrile, acetic acid, NMP, alcohols, and dichloromethane, and the inert atmosphere is one or a mixture of argon and nitrogen.
[0041] In some specific embodiments of the second aspect, the reaction temperature is 60–100°C, preferably 80°C.
[0042] In some specific embodiments of the second aspect, the reaction temperature is 60°C, 61°C, 62°C, 63°C, 64°C, 65°C, 66°C, 67°C, 68°C, 69°C, 70°C, 71°C, 72°C, 73°C, 74°C, 75°C, 76°C, 77°C, 78°C, 79°C, 80°C, 81°C, 82°C, 83°C, 84°C, 85°C, 86°C, 87°C, 88°C, 89°C, 90°C, 91°C, 92°C, 93°C, 94°C, 95°C, 96°C, 97°C, 98°C, 99°C, or 100°C.
[0043] The present invention has the following advantages:
[0044] This invention provides a novel, more efficient, economical, and simpler synthetic method to significantly improve the yield and purity of 5-chloro-2,4-diphenylpyrimidine, thereby optimizing the performance of organic electronic devices constructed based on organic light-emitting technology and providing stronger support for applications in display, lighting, and optoelectronics fields. Attached Figure Description
[0045] Figure 1 : The 1H NMR data of 5-amino-2,4-diphenylpyrimidine of this invention;
[0046] Figure 2 : The 1H NMR data of 5-chloro-2,4-diphenylpyrimidine of this invention. Detailed Implementation
[0047] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. Based on the embodiments of this application, all other embodiments obtained by those skilled in the art based on this application are within the scope of protection of this application.
[0048] The synthetic route of this invention can be summarized as follows:
[0049]
[0050] 5-Amino-2,4-dichloropyrimidine was reacted with phenylboronic acid, potassium carbonate, and palladium dichloride in a mixture of organic solvent and water under an inert atmosphere to form 5-amino-2,4-diphenylpyrimidine. 5-Amino-2,4-diphenylpyrimidine was then dissolved in a mixture of organic solvent and water, and hydrochloric acid and nitrite were added. The mixture was stirred to form a reaction system. Subsequently, the system was added dropwise to an acidic salt solution of chloride and kept at a constant temperature to obtain 5-chloro-2,4-diphenylpyrimidine.
[0051] Example 1: Synthesis of 5-amino-2,4-diphenylpyrimidine
[0052] The chemical reaction equation is as follows:
[0053]
[0054] Compound 1 (5 g, 30.5 mmol), phenylboronic acid (11.15 g, 91.5 mmol), potassium carbonate (12.6 g, 91.5 mmol), and palladium dichloride (0.42 g, 0.6 mmol) were added to a reaction flask, followed by toluene (160 mL), ethanol (40 mL), and water (20 mL). The mixture was purged with nitrogen three times. The mixture was heated to 80 °C and refluxed for 16 hours. TLC showed that the reaction was complete. The reaction solution was quenched with water, extracted with ethyl acetate, and the organic phase was retained. The organic phase was brushed onto a silica gel column, and the filtrate was concentrated to obtain the crude product. The crude product was then crystallized from ethyl acetate and petroleum ether to give compound 2, 4.9 g, in 65% yield.
[0055] 1H NMR spectrum of 5-amino-2,4-diphenylpyrimidine: 1 H NMR (400 MHz, Chloroform-d) δ 8.51- 8.33 (m, 3H), 7.90 (d, J = 7.2 Hz, 2H), 7.50 (m, 6H), 3.97 (s, 2H).
[0056] Example 2: Synthesis of 5-chloro-2,4-diphenylpyrimidine
[0057] The chemical reaction equation is as follows:
[0058]
[0059] Compound 2 (4.5 g, 18.2 mmol) was dissolved in a mixture of DMF (18 mL), acetic acid (18 mL), and water (9 mL) by stirring. Then, dilute hydrochloric acid (7.4 g, 72.8 mmol) was added and stirred at room temperature for 30 min, followed by cooling to -5°C. Sodium nitrite (1.4 g, 20.0 mmol) was added in portions, and the mixture was stirred at this temperature for 30 min after the addition was complete. This mixture was then added dropwise to a mixture of dilute hydrochloric acid (7.4 g, 72.8 mmol) and cuprous chloride (0.54 g, 5.5 mmol) at 70°C, and the temperature was maintained above 60°C. The mixture was then kept at 70°C for 1 hour. TLC showed that the reaction was complete. The reaction mixture was filtered to obtain a solid. The solid was dissolved in dichloromethane, dried over anhydrous sodium sulfate, and concentrated by column chromatography. The crude product was then crystallized from petroleum ether and ethyl acetate to give compound 3, 3.2 g, in 66% yield.
[0060] 1H NMR spectrum of 5-chloro-2,4-diphenylpyrimidine: 1H NMR (400 MHz, Chloroform-d) δ 8.84(s, 1H), 8.55 - 8.49 (m, 2H), 8.06- 8.00 (m, 2H), 7.59 - 7.51 (m, 6H).
[0061] Example 3: Synthesis of 5-chloro-2,4-diphenylpyrimidine
[0062] Compound 2 (5 g, 20.2 mmol) was dissolved in a mixture of DMF (20 mL), acetic acid (20 mL), and water (10 mL) by stirring. Then, 80% sulfuric acid (9.9 g, 80.8 mmol) was added and stirred at room temperature for 30 min, followed by cooling to -5°C. Sodium nitrite (1.5 g, 22.2 mmol) was added in portions, and the mixture was stirred at this temperature for 30 min after the addition was complete. This mixture was then added dropwise to a mixture of dilute hydrochloric acid (8.1 g, 80.8 mmol) and cuprous chloride (0.60 g, 6.1 mmol) at 70°C, and the temperature was maintained above 60°C. The mixture was then kept at 70°C for 1 hour. TLC showed that the reaction was complete. The reaction mixture was filtered to obtain a solid. The solid was dissolved in dichloromethane, dried over anhydrous sodium sulfate, and concentrated by column chromatography. The crude product was then crystallized from petroleum ether and ethyl acetate to give compound 3, 3.1 g, in 57.6% yield.
[0063] Example 4: Synthesis of 5-chloro-2,4-diphenylpyrimidine
[0064] Compound 2 (4.5 g, 18.2 mmol) was dissolved in a mixture of acetone (20 mL) and water (10 mL) by stirring. Then, 80% sulfuric acid (9.9 g, 80.8 mmol) was added and stirred at room temperature for 30 min, followed by cooling to -5°C. Sodium nitrite (1.5 g, 22.2 mmol) was added in portions, and the mixture was stirred at this temperature for 30 min after the addition was complete. This mixture was then added dropwise to a mixture of dilute hydrochloric acid (8.1 g, 80.8 mmol) and cuprous chloride (0.60 g, 6.1 mmol) at 70°C, and the temperature was maintained above 60°C. The mixture was then kept at 70°C for 1 hour. TLC showed that the reaction was complete. The reaction mixture was filtered to obtain a solid. The solid was dissolved in dichloromethane, dried over anhydrous sodium sulfate, and concentrated by column chromatography. The crude product was then crystallized from petroleum ether and ethyl acetate to give compound 3, 2.7 g, in 56.1% yield.
[0065] Example 5: Synthesis of 5-chloro-2,4-diphenylpyrimidine
[0066] Compound 2 (3 g, 12.13 mmol) was dissolved in a mixture of acetonitrile (12 mL), acetic acid (12 mL), and water (6 mL) by stirring. Then, dilute hydrochloric acid (4.9 g, 48.5 mmol) was added and stirred at room temperature for 30 min, followed by cooling to -5°C. Sodium nitrite (0.9 g, 13.34 mmol) was added in portions, and the mixture was stirred at this temperature for 30 min after the addition was complete. This mixture was then added dropwise to a mixture of dilute hydrochloric acid (4.9 g, 48.5 mmol) and cuprous chloride (0.36 g, 3.67 mmol) at 70°C, and the temperature was maintained above 60°C. The mixture was then kept at 70°C for 1 hour. TLC showed that the reaction was complete. The reaction mixture was filtered to obtain a solid. The solid was dissolved in dichloromethane, dried over anhydrous sodium sulfate, and concentrated by column chromatography. The crude product was then crystallized from petroleum ether and ethyl acetate to give compound 3, 1.8 g, in 55.7% yield.
[0067] The above-described embodiments are only used to illustrate the technical solutions of this application, and are not intended to limit them. Although this application has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some of the technical features. Such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of this application, and should all be included within the protection scope of this application.
Claims
1. A method for synthesizing 5-chloro-2,4-diphenylpyrimidine, characterized in that, Includes the following steps: S1. 5-Amino-2,4-dichloropyrimidine is reacted with phenylboronic acid, potassium carbonate and palladium dichloride of bis(triphenylphosphine) in a mixture of organic solvent and water under an inert atmosphere to obtain 5-amino-2,4-diphenylpyrimidine. S2. Dissolve 5-amino-2,4-diphenylpyrimidine in a mixture of organic solvent and water, add acid, stir, cool, then add nitrite and stir to form the first reaction system; then add dropwise to an acidic salt solution of chloride to form the second reaction system, and react to obtain 5-chloro-2,4-diphenylpyrimidine; ； In step S1, the molar ratio of 5-amino-2,4-dichloropyrimidine to phenylboronic acid is (142.5–162.5):(452.5–462.5); the molar ratio of potassium carbonate to palladium dichloride is (452.5–462.5):(2.5–3.5); the organic solvent is selected from one or a mixture of DMF, toluene, xylene, acetonitrile, acetic acid, NMP, alcohols, and dichloromethane; the inert gas atmosphere is one or a mixture of argon and nitrogen; and the reaction temperature is 60–100°C. In step S2, the molar ratio of 5-amino-2,4-diphenylpyrimidine to nitrite is (505~910):(555~1110); the molar ratio of acid to nitrite is (2020~4040):(555~1110); the acid is selected from hydrochloric acid, sulfuric acid, nitric acid, or a mixture thereof; the nitrite is sodium nitrite; the acidic salt solution of the chloride is an acidic cuprous chloride solution; the reaction temperature of the first reaction system is -10 to 0℃; the reaction temperature of the second reaction system is 60 to 80℃.
2. The method for synthesizing 5-chloro-2,4-diphenylpyrimidine according to claim 1, characterized in that, In step S1, the reaction temperature is 80°C.
3. The method for synthesizing 5-chloro-2,4-diphenylpyrimidine according to claim 1, characterized in that, In step S2, the reaction temperature of the first reaction system is -5℃.
4. The method for synthesizing 5-chloro-2,4-diphenylpyrimidine according to claim 1, characterized in that, In step S2, the reaction temperature of the second reaction system is 70°C.
5. The method for synthesizing 5-chloro-2,4-diphenylpyrimidine according to claim 1, characterized in that, In step S2, the amount of 5-amino-2,4-diphenylpyrimidine added per 1L of organic solvent is 505–910 mmol.
6. The method for synthesizing 5-chloro-2,4-diphenylpyrimidine according to claim 1, characterized in that, In step S2, the amount of 5-amino-2,4-diphenylpyrimidine added per 1L of organic solvent is 505mmol.
7. The method for synthesizing 5-chloro-2,4-diphenylpyrimidine according to claim 1, characterized in that, In step S2, the amount of acid added per 1L of organic solvent is 2020–4040 mmol.
8. The method for synthesizing 5-chloro-2,4-diphenylpyrimidine according to claim 1, characterized in that, In step S2, the amount of acid added per 1L of organic solvent is 2020mmol.
9. The method for synthesizing 5-chloro-2,4-diphenylpyrimidine according to claim 1, characterized in that, In step S2, the amount of nitrite added per 1L of the organic solvent is 555~1110 mmol.
10. The method for synthesizing 5-chloro-2,4-diphenylpyrimidine according to claim 1, characterized in that, In step S2, the amount of nitrite added per 1L of the organic solvent is 555mmol.
11. The method for synthesizing 5-chloro-2,4-diphenylpyrimidine according to claim 1, characterized in that, In step S1, the molar amount of 5-amino-2,4-dichloropyrimidine in each 1L of the organic solvent is 142.5 to 162.5 mmol.
12. The method for synthesizing 5-chloro-2,4-diphenylpyrimidine according to claim 1, characterized in that, In step S1, the molar amount of 5-amino-2,4-dichloropyrimidine in each 1L of the organic solvent is 152.5 mmol.
13. The method for synthesizing 5-chloro-2,4-diphenylpyrimidine according to claim 1, characterized in that, In step S1, the molar amount of phenylboronic acid in each 1L of the organic solvent is 452.5 to 462.5 mmol.
14. The method for synthesizing 5-chloro-2,4-diphenylpyrimidine according to claim 1, characterized in that, In step S1, the molar amount of phenylboronic acid in each 1L of the organic solvent is 457.5 mmol.
15. The method for synthesizing 5-chloro-2,4-diphenylpyrimidine according to claim 1, characterized in that, In step S1, the molar amount of potassium carbonate in each 1L of the organic solvent is 452.5 to 462.5 mmol.
16. The method for synthesizing 5-chloro-2,4-diphenylpyrimidine according to claim 1, characterized in that, In step S1, the molar amount of potassium carbonate in each 1L of the organic solvent is 457.5 mmol.
17. The method for synthesizing 5-chloro-2,4-diphenylpyrimidine according to claim 1, characterized in that, In step S1, the molar amount of palladium dichloride bis(triphenylphosphine) in each 1L of the organic solvent is 2.5 to 3.5 mmol.
18. The method for synthesizing 5-chloro-2,4-diphenylpyrimidine according to claim 1, characterized in that, In step S1, the molar amount of palladium dichloride bis(triphenylphosphine) in each 1L of the organic solvent is 3.0 mmol.