A traditional Chinese medicine composition for promoting blood circulation and dispelling cold, its application, hot compress patch containing the same and its preparation method

Abstract

The present invention belongs to the field of medical technology and relates to a traditional Chinese medicine composition for promoting blood circulation and dispelling cold, its application, a hot compress containing the composition, and a preparation method thereof. The composition comprises: bark of Bauhinia chinensis, cortex angelicae radix, root of Radix Trichosanthis, red peony root, notopterygium wilfordii, radix angelicae pubescens, thorn of Gleditsia sinensis, fruit of Nectarine, rhizoma Chuanxiong, forsythia suspensa, papaya, licorice, root of Gentiana macrophylla, angelica dahurica, root of Angelica sinensis, root of Saposhnikovia divaricata, longan, clematis root, gallnut, salvia miltiorrhiza, Achyranthes bidentata, and Scolopendra sinensis. The composition is synergistically formulated with multiple prescriptions for promoting blood circulation and menstruation, dispelling wind and dampness, and removing blood stasis and relieving pain. The composition has excellent effects and strong universality in treating musculoskeletal diseases such as cervical spondylosis, lumbar spondylosis, osteoarthritis, knee arthritis, osteoporosis, piriformis syndrome, or lumbar muscle strain. The composition also exhibits rapid effects, no discomfort, high patient acceptance, and a short treatment cycle.

Description

Technical Field

[0001] The invention belongs to the technical field of medicine, and relates to a traditional Chinese medicine composition for promoting blood circulation and dispelling cold, an application thereof, a hot compress patch containing the composition, and a preparation method thereof. Background Art

[0002] Musculoskeletal disorders include both muscle injuries and bone diseases. Musculoskeletal injuries include trauma and strain, while bone diseases include degenerative or metabolic bone diseases. Musculoskeletal disorders are common and frequently encountered orthopedic conditions, and are also considered difficult to treat. Western orthopedic medicine often focuses solely on open trauma, obvious fractures, and dislocations. Beyond these, there are no better treatment options. If patients with muscle injuries do not receive adequate treatment in the acute phase, they often develop chronic injuries. Compensatory limb function leads to secondary strain of bones, joints, and muscles, ultimately leading to illness. This complicates subsequent diagnosis and treatment, and consumes medical expenses and resources. For degenerative and metabolic bone diseases, current conventional Western anti-inflammatory and anti-osteoporosis drug therapies do not fundamentally improve the prognosis. Furthermore, long-term medication not only creates a significant medical burden but also comes with a host of systemic side effects. The rational use of Traditional Chinese Medicine (TCM) techniques can improve patients' functional status, slow disease progression, and enhance their quality of life.

[0003] Some of TCM's distinctive diagnostic and treatment techniques have unique advantages in the treatment of bone and muscle diseases. TCM's distinctive treatment plans, which mainly use special Chinese medicine bags for external application and traumatology techniques from various schools, are widely used in clinical practice and have certain therapeutic effects.

[0004] Chinese invention patent application CN110624078A discloses a tendon injury ointment and its preparation process. The raw materials for the ointment include Bauhinia bark, Vitex negundo fruit, Salvia miltiorrhiza, Licorice root, Ligusticum chuanxiong, Notopterygium wilfordii, Angelica pubescens, Saposhnikovia divaricata, Atractylodes stephania tetrandra, Forsythia suspensa, Gentiana macrophylla, Paeonia lactiflora, Angelica dahurica, Angelica sinensis, Perennial Root, Clematidis, processed Strychnos nux vomica, Papaya, Radix Trichosanthis, Laurocapram, Achyranthes bidentata, Curcuma longa and malt sugar. The ointment can effectively relieve pain in parts of the body, but the Atractylodes stephania tetrandra used in the ointment is contraindicated for pregnant women, infants and children, and those with renal insufficiency, and lacks practical value.

[0005] Chinese invention patent CN111084842B discloses a Chinese medicine composition for external use for treating periarthritis of shoulder, cervical spondylosis, lumbar disc herniation and osteoarthritis. The composition comprises the following raw materials in parts by weight: 55-65 parts of Rhizoma Cyperi, 30-38 parts of Rhubarb, 75-85 parts of Taraxacum mongolicum, 22-28 parts of Papaya, 20-30 parts of Angelica sinensis, 20-30 parts of Pheretima wormwood, 20-30 parts of Herba Eupatorii, 30-38 parts of Areca catechu, 30-40 parts of Achyranthes bidentata, 30-40 parts of Earthworm, 30-40 parts of Blood Scorpion, 50-60 parts of Panax notoginseng, 33-40 parts of Radix Trichosanthis, 30-38 parts of Polygonum cuspidatum, 30-40 parts of Carthamus tinctorius, 50-60 parts of Notopterygium wilfordii and 50-60 parts of Angelica dahurica. It can effectively relieve frozen shoulder, with an overall cure rate of up to 98%; however, its overall cure rate for cervical spondylosis, lumbar disc herniation, and osteoarthritis is lower, and its universality is poor.

[0006] It can be seen that there are currently many types of traditional Chinese medicine ingredients for common diseases of the musculoskeletal system. In order to give full play to the efficacy of each traditional Chinese medicine ingredient and improve the universality and therapeutic effect of the preparation, the formula and preparation process of such traditional Chinese medicine compositions and plasters still need to be further studied. Summary of the Invention

[0007] The present invention addresses the problems of the prior art and provides a traditional Chinese medicine composition for promoting blood circulation and dispelling cold, its use, a hot compress containing the composition, and a preparation method. The composition utilizes a combination of various prescriptions for promoting blood circulation, dredge menstruation, dispelling wind and dampness, removing blood stasis and relieving pain, and warming the meridians and dispelling cold. The composition is highly universal, has a rapid effect, and has safe ingredients with no toxic side effects.

[0008] To achieve the above object, the technical solution adopted by the present invention is as follows:

[0009] The invention provides a traditional Chinese medicine composition for promoting blood circulation and dispelling cold, which is characterized by comprising: bark of bauhinia, cortex perilla, root of trichosanthes, red peony root, notopterygium root, angelica root, thorn of honeysuckle, fruit of yellow vitex, rhizome of ligusticum, forsythia suspensa, papaya, liquorice, gentiana macrophylla, angelica dahurica, angelica sinensis, siler, turmeric, clematis root, gallnut, salvia miltiorrhiza, achyranthes bidentata and centipede.

[0010] Preferably, the ingredients include, by weight: 5-15 parts of Bauhinia bark, 1-5 parts of Periploca odorata, 1-8 parts of Radix Trichosanthis, 1-6 parts of Red Peony Root, 0.5-5 parts of Notopterygium wilfordii, 1-5 parts of Angelica dahurica, 0.1-4 parts of Spina Gleditsiae, 5-10 parts of Vitex Nguptae, 0.5-5 parts of Rhizoma Chuanxiong, 0.2-1.2 parts of Forsythia suspensa, 0.5-4 parts of Chaenomeles sinensis, 0.2-0.8 parts of Licorice, 1-4 parts of Gentiana macrophylla, 0.5-1.5 parts of Angelica dahurica, 1.2-3 parts of Angelica sinensis, 1.5-2.5 parts of Saposhnikovia divaricata, 1-3 parts of Curcuma longa, 1-3 parts of Clematis chinensis, 0.5-2 parts of Gallnut, 0.5-5 parts of Salvia miltiorrhiza, 0.5-5 parts of Achyranthes bidentata and 0.1-1 parts of Scolopendra.

[0011] More preferably, the ingredients include, by weight: 10-12 parts of Bauhinia bark, 1-3 parts of Periploca odorata, 2-6 parts of Radix Trichosanthis, 1-3 parts of Red Peony Root, 1.5-2.5 parts of Notopterygium wilfordii, 1.5-2.5 parts of Angelica dahurica, 0.5-2 parts of Spina Gleditsiae, 7-9 parts of Vitex negundo, 1-3 parts of Rhizoma Chuanxiong, 0.5-1 parts of Forsythia suspensa, 1-3 parts of Papaya, 0.4-0.6 parts of Glycyrrhiza uralensis, 1-3 parts of Gentiana macrophylla, 0.8-1.2 parts of Angelica dahurica, 1.6-2.4 parts of Angelica sinensis, 1.8-2.2 parts of Saposhnikovia divaricata, 1.5-2.5 parts of Curcuma longa, 1.5-2.5 parts of Clematidis, 0.8-1.2 parts of Gallnut, 1-3 parts of Salvia miltiorrhiza, 1-3 parts of Achyranthes bidentata and 0.3-0.8 parts of Scolopendra.

[0012] Further preferably, the ingredients include, by weight: 8 parts of Bauhinia bark, 2 parts of Periploca odorata, 4 parts of Radix Trichosanthis, 2 parts of Red Peony Root, 2 parts of Notopterygium wilfordii, 2 parts of Angelica dahurica, 1 part of Gleditsia sinensis, 8 parts of Vitex negundo, 2 parts of Ligusticum chuanxiong, 1 part of Forsythia suspensa, 2 parts of Papaya, 0.5 parts of Licorice, 2 parts of Gentiana macrophylla, 1 part of Angelica dahurica, 2 parts of Angelica sinensis, 2 parts of Saposhnikovia divaricata, 2 parts of Curcuma longa, 2 parts of Clematidis, 1 part of Gallnut, 2 parts of Salvia miltiorrhiza, 2 parts of Achyranthes bidentata and 0.5 parts of Scolopendra.

[0013] As some preferred technical solutions of the present invention, the mass ratio of the Bauhinia bark, Vitex negundo fruit and Salvia miltiorrhiza is 10-15:5-10:1-5.

[0014] As some preferred technical solutions of the present invention, the mass ratio of Notopterygium wilfordii and Angelica dahurica is 1:1-1.5.

[0015] Each raw material of the present invention has the following effects:

[0016] Bauhinia bark treats muscle and bone pain, wind-cold-dampness arthritis, numbness, paralysis, and weakness, warms the tendons, and relieves low back pain; it also promotes blood circulation and qi, reduces swelling and detoxifies. Persimmon peel promotes diuresis and reduces swelling, dispels rheumatism, and strengthens the bones and muscles. It is used for lower limb edema, palpitations, shortness of breath, wind-cold-dampness arthritis, and soreness of the waist and knees. Trichosanthes root is used to clear heat and promote fluid production, reduce swelling and discharge pus; the Southern Yunnan Materia Medica records that "Trichosanthes root treats traumatic injuries and unbearable chest pain." Red peony root is used to promote blood circulation, relieve pain, clear heat and cool the blood, and reduce swelling. Notopterygium root dispels cold, dispels wind and dampness, and relieves pain. It is used to treat colds caused by wind and cold, headaches, stiff necks, rheumatic pain, and shoulder and back pain. Duhuo root dispels wind and dampness, relieves numbness, and relieves pain. It belongs to the category of anti-rheumatic and anti-cold drugs, which are classified as anti-rheumatic and anti-cold drugs. Sophora japonica thorn has a pungent, warm, and salty flavor. Its pungent properties can dissipate heat and promote blood circulation and qi, soften and disperse lumps, and its warm properties can dispel wind and promote blood circulation and remove blood stasis. Huangjingzi dispels wind and heat, benefits joints; treats rheumatic pain. Chuanxiong promotes qi and relieves depression, dispels wind and dampness, activates blood circulation and relieves pain. Qingqiaolian clears heat, detoxifies, disperses stagnation, and reduces swelling. Papaya relaxes tendons and activates collaterals, dissipates dampness and harmonizes the stomach, and aids digestion. Licorice nourishes the spleen and replenishes qi, clears heat and detoxifies, dispels phlegm and relieves cough, relieves acute pain, and harmonizes various herbs. The Bencao Jing states that it "treats cold and heat pathogens in the five internal organs and six bowels, strengthens tendons and bones, increases muscle strength, treats wounds and swelling, and detoxifies." Gentiana macrophylla dispels wind and dampness, harmonizes blood circulation and relaxes tendons, clears heat and promotes urination. It treats rheumatic pain, tendon and bone cramps, etc. Baizhi dispels wind, dries dampness, reduces swelling, and relieves pain. Angelica sinensis is rich in volatile components, organic acids, sugars, vitamins, amino acids, inorganic elements, alkaline compounds, and ingredients such as stigmasterol and sitosterol. It promotes hemoglobin and red blood cell production, relieves peripheral vascular smooth muscle spasms, increases blood flow, improves peripheral circulation, and has anti-thrombotic, analgesic, anti-inflammatory, and immune-enhancing properties. Saposhnikovia divaricata is primarily used to treat exogenous wind-cold, headaches, dizziness, stiff neck, wind-cold-damp arthritis, joint pain, limb spasms, and tetanus. Curcuma longa promotes blood circulation and qi circulation, relieving pain from menstruation. Clematis chinensis is used to treat rheumatic pain, numbness of the limbs, muscle spasms, difficulty flexing and extending, and bone blockage in the throat. Gallnut astringent nourishes the lungs and reduces internal heat, astringes the intestines and stops diarrhea, stops bleeding, and detoxifies. Salvia miltiorrhiza removes blood stasis and relieves pain, promotes blood circulation and promotes menstruation, and clears the heart and relieves restlessness. Achyranthes bidentata is used to treat low back and knee pain, weak tendons and bones, and lower limb weakness. Centipede herb calms wind and relieves spasms, and eliminates toxins and resolves stagnation.

[0017] The present invention also provides the use of any of the above-mentioned traditional Chinese medicine compositions in the preparation of medicines for treating musculoskeletal diseases.

[0018] Furthermore, the musculoskeletal diseases include cervical spondylosis, lumbar spondylosis, osteoarthritis, knee arthritis, osteoporosis, piriformis syndrome and / or lumbar muscle strain.

[0019] Furthermore, the medicine is an oral liquid or an external hot compress.

[0020] The present invention also provides a traditional Chinese medicine hot compress patch, comprising any of the above-mentioned traditional Chinese medicine compositions and a heating material.

[0021] Furthermore, the heating material includes at least two of iron powder, activated carbon, vermiculite, panthenolite and industrial salt.

[0022] The present invention also provides a method for preparing the above-mentioned Chinese medicine hot compress patch, comprising the following steps:

[0023] (1) Cinnabar bark, Perennial Herb, Radix Trichosanthis, Red Peony Root, Notopterygium wilfordii, Angelica dahurica, Gleditsia sinensis, Vitex negundo, Rhizoma Chuanxiong, Forsythia suspensa, Chaenomeles sinensis, Licorice root, Gentiana macrophylla, Angelica dahurica, Angelica sinensis, Saposhnikovia divaricata, Curcuma longa, Radix Clematis, Gallnut, Salvia miltiorrhiza, Achyranthes bidentata, and Scolopendra subspinipes were crushed and sieved to obtain raw material powder;

[0024] (2) adding the raw medicinal powder to water for grinding and leaching to obtain a Chinese medicine composition;

[0025] (3) Mix the Chinese medicine composition with the heating material to obtain

[0026] Furthermore, in step (2), the mass volume ratio of the raw material powder to water is 1:1-5 g / mL.

[0027] Furthermore, the mass ratio of the traditional Chinese medicine composition to the heating material is 1:0.2-0.5.

[0028] Compared with the prior art, the present invention has the following beneficial effects:

[0029] (1) The Chinese medicine composition is prepared by synergizing multiple Chinese medicinal ingredients and optimizing the selection and dosage of the Chinese medicinal ingredients to achieve significant effects of promoting blood circulation and menstruation, dispelling wind and dampness, removing blood stasis and relieving pain, and warming the meridians and dispersing cold;

[0030] (2) The Chinese medicine composition has a rapid onset of action, effectively shortening the treatment period for musculoskeletal diseases such as cervical spondylosis, lumbar spondylosis, osteoarthritis, knee arthritis, osteoporosis, piriformis syndrome, and / or lumbar muscle strain, thereby improving the quality of life of patients;

[0031] (3) The heating patch prepared by combining the Chinese medicine composition of the present invention with a suitable heating material in a certain ratio can be directly applied to the painful area without discomfort and has high patient acceptance. It has a good effect on the treatment of bone and joint diseases such as cervical vertebrae, lumbar vertebrae, knee joints, hip joints, etc. and has strong universality.

[0032] (4) The hot compress patch of traditional Chinese medicine for promoting blood circulation and dispelling cold has a simple preparation process and high efficiency, which greatly reduces the production cost. DETAILED DESCRIPTION

[0033] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the embodiments described are part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention. It is worth noting that the raw materials used in the present invention are all common commercially available products, and their sources are not specifically limited.

[0034] Example 1

[0035] A traditional Chinese medicine composition comprises, by weight, 8 parts of Bauhinia bark, 2 parts of Periploca odorata bark, 4 parts of Radix Trichosanthis, 2 parts of Red Peony Root, 2 parts of Notopterygium wilfordii, 2 parts of Angelica dahurica, 1 part of Gleditsia sinensis spinosa, 8 parts of Vitex negundo fruit, 2 parts of Ligusticum chuanxiong, 1 part of Forsythia suspensa, 2 parts of Chaenomeles sinensis, 0.5 part of Licorice root, 2 parts of Gentiana macrophylla, 1 part of Angelica dahurica, 2 parts of Angelica sinensis, 2 parts of Saposhnikovia divaricata, 2 parts of Curcuma longa, 2 parts of Clematidis root, 1 part of Gallnut, 2 parts of Salvia miltiorrhiza, 2 parts of Achyranthes bidentata and 0.5 part of Scolopendra subspinipes.

[0036] A traditional Chinese medicine hot compress patch for promoting blood circulation and dispelling cold comprises the above-mentioned traditional Chinese medicine composition and a heating material, wherein the heating material is iron powder, vermiculite powder and activated carbon in a mass ratio of 1:1:1 (wherein each patch contains 0.5 g of the traditional Chinese medicine composition).

[0037] Weigh the raw materials according to the above ratio, mix them, grind them and pass them through a 100-mesh sieve, mix them with water at a material-liquid ratio of 1:2, add them into a grinder, and grind them thoroughly to obtain a traditional Chinese medicine composition. The traditional Chinese medicine composition and the heating material are fully mixed and ground at a mass ratio of 1:0.4 to obtain the product.

[0038] Example 2

[0039] A traditional Chinese medicine composition comprises, by weight, 12 parts of Bauhinia bark, 2 parts of Periploca odorata bark, 5 parts of Radix Trichosanthis, 3 parts of Red Peony Root, 2.5 parts of Notopterygium wilfordii, 2.5 parts of Angelica dahurica, 1.5 parts of Gleditsia spinosa, 7 parts of Vitex negundo fruit, 3 parts of Ligusticum chuanxiong, 0.5 part of Forsythia suspensa, 1 part of Chaenomeles sinensis, 0.5 part of Licorice root, 1 part of Gentiana macrophylla, 1 part of Angelica dahurica, 1.8 parts of Angelica sinensis, 1.8 parts of Saposhnikovia divaricata, 2.5 parts of Curcuma longa, 2.5 parts of Clematis chinensis, 0.8 part of Gallnut, 3 parts of Salvia miltiorrhiza, 3 parts of Achyranthes bidentata and 0.3 part of Scolopendra subspinipes.

[0040] A traditional Chinese medicine hot compress patch for promoting blood circulation and dispelling cold comprises the above-mentioned traditional Chinese medicine composition and a heating material, wherein the heating material is iron powder and panthenol powder in a mass ratio of 1:1.

[0041] Weigh the raw materials according to the above ratio, mix them, grind them and pass them through a 100-mesh sieve, mix them with water at a material-liquid ratio of 1:3, add them into a grinder, and grind them thoroughly to obtain a traditional Chinese medicine composition. The traditional Chinese medicine composition and the heating material are fully mixed and ground at a mass ratio of 1:0.5 to obtain the product.

[0042] Example 3

[0043] A traditional Chinese medicine composition comprises, by weight, 15 parts of Bauhinia bark, 1 part of Periploca odorata bark, 1 part of Radix Trichosanthis, 5 parts of Red Peony Root, 5 parts of Notopterygium wilfordii, 5 parts of Angelica dahurica, 0.5 part of Gleditsia sinensis Spinach, 10 parts of Vitex negundo Fructus, 1 part of Ligusticum chuanxiong, 0.5 part of Forsythia suspensa, 0.5 part of Chaenomeles sinensis, 0.8 part of Licorice, 1 part of Gentiana macrophylla, 1.5 parts of Angelica dahurica, 3 parts of Angelica sinensis, 1.5 parts of Saposhnikovia divaricata, 1 part of Curcuma longa, 1 part of Clematidis, 2 parts of Gallnut, 5 parts of Salvia miltiorrhiza, 0.5 part of Achyranthes bidentata and 1 part of Scolopendra subspinipes.

[0044] A traditional Chinese medicine hot compress patch for promoting blood circulation and dispelling cold comprises the above-mentioned traditional Chinese medicine composition and a heating material, wherein the heating material is iron powder and activated carbon in a mass ratio of 1:1.

[0045] Weigh the raw materials according to the above ratio, mix them, grind them and pass them through a 100-mesh sieve, mix them with water at a material-liquid ratio of 1:1, add them into a grinder, and grind them thoroughly to obtain a traditional Chinese medicine composition. The traditional Chinese medicine composition and the heating material are fully mixed and ground at a mass ratio of 1:0.2 to obtain the product.

[0046] Example 4

[0047] A traditional Chinese medicine composition comprises, by weight, 7.5 parts of Bauhinia bark, 2 parts of Periploca odorata bark, 4 parts of Radix Trichosanthis, 2 parts of Red Peony Root, 2 parts of Notopterygium wilfordii, 2 parts of Angelica dahurica, 1 part of Gleditsia sinensis spinosa, 10 parts of Vitex negundo fruit, 2 parts of Ligusticum chuanxiong, 1 part of Forsythia suspensa, 2 parts of Chaenomeles sinensis, 0.5 part of Glycyrrhiza uralensis, 2 parts of Gentiana macrophylla, 1 part of Angelica dahurica, 2 parts of Angelica sinensis, 2 parts of Saposhnikovia divaricata, 2 parts of Curcuma longa, 2 parts of Clematis chinensis, 1 part of Gallnut, 0.5 part of Salvia miltiorrhiza, 2 parts of Achyranthes bidentata and 0.5 part of Scolopendra subspinipes.

[0048] A traditional Chinese medicine hot compress patch for promoting blood circulation and dispelling cold comprises the above-mentioned traditional Chinese medicine composition and a heating material, wherein the heating material is iron powder, vermiculite powder and activated carbon in a mass ratio of 1:1:1.

[0049] Weigh the raw materials according to the above ratio, mix them, grind them and pass them through a 100-mesh sieve, mix them with water at a material-liquid ratio of 1:2, add them into a grinder, and grind them thoroughly to obtain a traditional Chinese medicine composition. The traditional Chinese medicine composition and the heating material are fully mixed and ground at a mass ratio of 1:0.4 to obtain the product.

[0050] Example 5

[0051] A traditional Chinese medicine composition comprises, by weight, 8 parts of Bauhinia bark, 2 parts of Periploca odorata bark, 4 parts of Radix Trichosanthis, 2 parts of Red Peony Root, 3 parts of Notopterygium wilfordii, 1 part of Angelica dahurica Root, 1 part of Sophora japonica Root, 8 parts of Vitex negundo Fruit, 2 parts of Ligusticum chuanxiong, 1 part of Forsythia suspensa, 2 parts of Chaenomeles sinensis, 0.5 part of Licorice, 2 parts of Gentiana macrophylla, 1 part of Angelica dahurica, 2 parts of Angelica sinensis, 2 parts of Saposhnikovia divaricata, 2 parts of Curcuma longa, 2 parts of Clematidis, 1 part of Gallnut, 2 parts of Salvia miltiorrhiza, 2 parts of Achyranthes bidentata and 0.5 part of Scolopendra subspinipes.

[0052] A traditional Chinese medicine hot compress patch for promoting blood circulation and dispelling cold comprises the above-mentioned traditional Chinese medicine composition and a heating material, wherein the heating material is iron powder, vermiculite powder and activated carbon in a mass ratio of 1:1:1.

[0053] Weigh the raw materials according to the above ratio, mix them, grind them and pass them through a 100-mesh sieve, mix them with water at a material-liquid ratio of 1:2, add them into a grinder, and grind them thoroughly to obtain a traditional Chinese medicine composition. The traditional Chinese medicine composition and the heating material are fully mixed and ground at a mass ratio of 1:0.4 to obtain the product.

[0054] Example 6

[0055] A traditional Chinese medicine composition comprises, by weight, 8 parts of Bauhinia bark, 2 parts of Periploca odorata bark, 4 parts of Radix Trichosanthis, 2 parts of Red Peony Root, 2 parts of Notopterygium wilfordii, 2 parts of Angelica dahurica, 1 part of Gleditsia sinensis spinosa, 8 parts of Vitex negundo fruit, 2 parts of Ligusticum chuanxiong, 1 part of Forsythia suspensa, 2 parts of Chaenomeles sinensis, 0.5 part of Licorice root, 2 parts of Gentiana macrophylla, 1 part of Angelica dahurica, 2 parts of Angelica sinensis, 2 parts of Saposhnikovia divaricata, 2 parts of Curcuma longa, 2 parts of Clematidis root, 1 part of Gallnut, 2 parts of Salvia miltiorrhiza, 2 parts of Achyranthes bidentata and 0.5 part of Scolopendra subspinipes.

[0056] A traditional Chinese medicine hot compress patch for promoting blood circulation and dispelling cold comprises the above-mentioned traditional Chinese medicine composition and a heating material, wherein the heating material is iron powder and vermiculite powder in a mass ratio of 1:1.

[0057] Weigh the raw materials according to the above ratio, mix them, grind them and pass them through a 100-mesh sieve, mix them with water at a material-liquid ratio of 1:2, add them into a grinder, and grind them thoroughly to obtain a traditional Chinese medicine composition. The traditional Chinese medicine composition and the heating material are fully mixed and ground at a mass ratio of 1:0.4 to obtain the product.

[0058] Example 7

[0059] A traditional Chinese medicine composition comprises, by weight, 8 parts of Bauhinia bark, 2 parts of Periploca odorata bark, 4 parts of Radix Trichosanthis, 2 parts of Red Peony Root, 2 parts of Notopterygium wilfordii, 2 parts of Angelica dahurica, 1 part of Gleditsia sinensis spinosa, 8 parts of Vitex negundo fruit, 2 parts of Ligusticum chuanxiong, 1 part of Forsythia suspensa, 2 parts of Chaenomeles sinensis, 0.5 part of Licorice root, 2 parts of Gentiana macrophylla, 1 part of Angelica dahurica, 2 parts of Angelica sinensis, 2 parts of Saposhnikovia divaricata, 2 parts of Curcuma longa, 2 parts of Clematidis root, 1 part of Gallnut, 2 parts of Salvia miltiorrhiza, 2 parts of Achyranthes bidentata and 0.5 part of Scolopendra subspinipes.

[0060] A traditional Chinese medicine hot compress patch for promoting blood circulation and dispelling cold comprises the above-mentioned traditional Chinese medicine composition and a heating material, wherein the heating material is iron powder and vermiculite powder in a mass ratio of 1:1.

[0061] Weigh the raw materials according to the above ratio, mix them, grind them and pass them through a 100-mesh sieve, mix them with water at a material-liquid ratio of 1:2, add them into a grinder, and grind them thoroughly to obtain a traditional Chinese medicine composition. The traditional Chinese medicine composition and the heating material are fully mixed and ground at a mass ratio of 1:0.5 to obtain the product.

[0062] Example 8

[0063] A traditional Chinese medicine composition comprises, by weight, 8 parts of Bauhinia bark, 2 parts of Periploca odorata bark, 4 parts of Radix Trichosanthis, 2 parts of Red Peony Root, 2 parts of Notopterygium wilfordii, 2 parts of Angelica dahurica, 1 part of Gleditsia sinensis spinosa, 8 parts of Vitex negundo fruit, 2 parts of Ligusticum chuanxiong, 1 part of Forsythia suspensa, 2 parts of Chaenomeles sinensis, 0.5 part of Licorice root, 2 parts of Gentiana macrophylla, 1 part of Angelica dahurica, 2 parts of Angelica sinensis, 2 parts of Saposhnikovia divaricata, 2 parts of Curcuma longa, 2 parts of Clematidis root, 1 part of Gallnut, 2 parts of Salvia miltiorrhiza, 2 parts of Achyranthes bidentata and 0.5 part of Scolopendra subspinipes.

[0064] A traditional Chinese medicine hot compress patch for promoting blood circulation and dispelling cold comprises the above-mentioned traditional Chinese medicine composition and a heating material, wherein the heating material is iron powder, vermiculite powder and activated carbon in a mass ratio of 1:1:1.

[0065] Weigh the raw materials according to the above ratio, mix them, grind them and pass them through a 100-mesh sieve, mix them with water at a material-liquid ratio of 1:2, add them into a grinder, and grind them thoroughly to obtain a traditional Chinese medicine composition. The traditional Chinese medicine composition and the heating material are fully mixed and ground at a mass ratio of 1:0.2 to obtain the product.

[0066] Comparative Example 1

[0067] The only difference from Example 1 is that the Chinese medicine composition does not contain Gleditsia thorn, Gallnut and Centipede;

[0068] Specifically: the Chinese medicine composition includes, by weight: 8 parts of Bauhinia bark, 2 parts of Perennial Perilla Bark, 4 parts of Radix Trichosanthis, 2 parts of Red Peony Root, 2 parts of Notopterygium wilfordii, 2 parts of Angelica dahurica, 8 parts of Vitex Ngauji, 2 parts of Ligusticum chuanxiong, 1 part of Forsythia suspensa, 2 parts of Papaya, 0.5 parts of Licorice, 2 parts of Gentiana macrophylla, 1 part of Angelica dahurica, 2 parts of Angelica sinensis, 2 parts of Saposhnikovia divaricata, 2 parts of Curcuma longa, 2 parts of Clematidis, 2 parts of Salvia miltiorrhiza and 2 parts of Achyranthes bidentata.

[0069] A traditional Chinese medicine hot compress for promoting blood circulation and dispelling cold is prepared by replacing the traditional Chinese medicine composition of Example 1 with the above traditional Chinese medicine composition, and the preparation method is the same as that of Example 1.

[0070] Comparative Example 2

[0071] The only difference from Example 1 is that the Chinese medicine composition does not contain Gleditsia thorn, Gallnut and Centipede; instead, 2.5 parts of processed Strychnos nux vomica are used.

[0072] Specifically: the Chinese medicine composition includes, by weight: 8 parts of Bauhinia bark, 2 parts of Periploca odorata bark, 4 parts of Radix Trichosanthis, 2 parts of Red Peony Root, 2 parts of Notopterygium wilfordii, 2 parts of Angelica dahurica, 2 parts of Angelica pubescens, 2.5 parts of processed Strychnos nux vomica, 8 parts of Vitex negundo, 2 parts of Ligusticum chuanxiong, 1 part of Forsythia suspensa, 2 parts of Papaya, 0.5 parts of Licorice, 2 parts of Gentiana macrophylla, 1 part of Angelica dahurica, 2 parts of Angelica sinensis, 2 parts of Saposhnikovia divaricata, 2 parts of Curcuma longa, 2 parts of Clematidis, 2 parts of Salvia miltiorrhiza and 2 parts of Achyranthes bidentata.

[0073] A traditional Chinese medicine hot compress for promoting blood circulation and dispelling cold is prepared by replacing the traditional Chinese medicine composition of Example 1 with the above traditional Chinese medicine composition, and the preparation method is the same as that of Example 1.

[0074] Comparative Example 3

[0075] The only difference from Example 1 is that the amount of each raw material in the Chinese medicine composition is different;

[0076] Specifically: the Chinese medicine composition includes, by weight: 3 parts of Bauhinia bark, 4 parts of Perennial Perilla Bark, 6 parts of Radix Trichosanthis, 4 parts of Red Peony Root, 5 parts of Notopterygium, 3 parts of Angelica dahurica, 1 part of Gleditsia Spinach, 3 parts of Vitex Ngawain Fruit, 5 parts of Ligusticum chuanxiong, 3 parts of Forsythia suspensa, 6 parts of Papaya, 0.8 parts of Licorice, 4 parts of Gentiana macrophylla, 5 parts of Angelica dahurica, 5 parts of Angelica sinensis, 4 parts of Saposhnikovia divaricata, 5 parts of Curcuma longa, 5 parts of Clematidis, 1 part of Gallnut, 5 parts of Salvia miltiorrhiza, 6 parts of Achyranthes bidentata and 0.5 parts of Scolopendra.

[0077] A traditional Chinese medicine hot compress for promoting blood circulation and dispelling cold is prepared by replacing the traditional Chinese medicine composition of Example 1 with the above traditional Chinese medicine composition, and the preparation method is the same as that of Example 1.

[0078] Comparative Example 4

[0079] The only difference from Example 3 is that the heating material is iron powder, and the mass ratio of the Chinese medicine composition to the heating material is 1:0.8.

[0080] A traditional Chinese medicine hot compress patch for promoting blood circulation and dispelling cold is prepared by replacing the heating material in Example 1 with the heating material described above. The preparation method is the same as that in Example 1.

[0081] Comparative Example 5

[0082] The only difference from Example 3 is that the heating material is activated carbon, and the mass ratio of the Chinese medicine composition to the heating material is 1:1.

[0083] A traditional Chinese medicine hot compress patch for promoting blood circulation and dispelling cold is prepared by replacing the heating material in Example 1 with the heating material described above. The preparation method is the same as that in Example 1.

[0084] 1. Effects on traumatic bruising and swelling in the plantar area of ​​mice

[0085] One hundred and fifty healthy adult C57BL / 6 mice were randomly divided into 13 groups, each containing 10 mice, half male and half female. A cylinder with an inner diameter of 3.2 cm and a length of 27 cm was placed vertically on the left hind paw of the mouse. A 200g weight was then applied vertically downward from inside the cylinder to the plantar region of the mouse's paw, causing acute traumatic swelling and hemorrhage.

[0086] 48 hours after modeling, the Chinese medicine patches prepared in Examples 1-8 and Comparative Examples 1-5 were respectively applied to the swollen bruises on the left hind paw of the corresponding experimental group mice. The patches were applied once a day for 6 hours each time for 3 consecutive days, and the bruise disappearance time was observed (starting from the end of modeling); and 2 hours after the last application, the mice were killed, and the left and right feet were cut off 4 mm above the ankle joint and weighed. The difference was the swelling degree, and the data of 10 mice were averaged. The results are shown in Table 1.

[0087] Table 1

[0088] Swelling degree (mg) Bruising disappearance time (h) Example 1 32.1 23.6 Example 2 38.4 30.2 Example 3 33.2 29.4 Example 4 40.3 25.6 Example 5 36.4 28.7 Example 6 35.6 27.9 Example 7 32.8 25.6 Example 8 42.3 32.5 Comparative Example 1 90.4 72.3 Comparative Example 2 74.6 66.5 Comparative Example 3 52.9 43.2 Comparative Example 4 35.2 25.5 Comparative Example 5 39.6 24.4

[0089] As can be seen from the table above, the ankle swelling of mice using the Chinese herbal hot compresses of Examples 1-5 was around 40 mg, with the lowest being only 32.1 mg; the time for ecchymosis to disappear was no more than 30 hours. In contrast, the ankle swelling of mice in Comparative Example 1 was as high as 90.4 mg, and the time for ecchymosis to disappear was as long as 72.3 hours, indicating that the effect of the Chinese herbal hot compress patch was significantly reduced even with a constant total amount of Chinese herbal medicine after the patch lacked some of its ingredients. The ankle swelling and ecchymosis disappearance time of mice in Comparative Examples 2 and 3 also increased to varying degrees, indicating that the replacement of some Chinese herbal ingredients and changes in dosage will affect the recovery of traumatic bruises and swelling. In addition, Comparative Examples 4 and 5 only used a single heating material. When the amount of Chinese herbal ingredients was the same, the dosage of the heating material using a single ingredient had to be increased by 8-10 times relative to when two materials were used to achieve the corresponding effect.

[0090] 2. Impact on the recovery of local tissue damage

[0091] One hundred and fifty healthy adult C57BL / 6 mice were randomly divided into 15 groups: control, model, and experimental groups 1-13, with 10 mice per group, half male and half female. The mice in the model and experimental groups were anesthetized, and after skin preparation and disinfection, a 0.5 cm longitudinal incision was made below the right knee joint. A 22G / 0.41 mm intramedullary fixation pin was inserted through the patellar tendon. The muscle and fascia were separated at the mid-superior third of the tibia. The tibial shaft was sawed and immediately flushed with 0.9% saline. The intramedullary fixation pin was then fully inserted and sutured. The incision was sutured layer by layer to create a right tibial shaft fracture model in mice.

[0092] 72 hours after modeling, the herbal compresses prepared in Examples 1-8 and Comparative Examples 1-5 were applied to the right tibial shaft fracture site of the corresponding experimental group mice. The compresses were applied once daily for 6 hours for 3 consecutive days. Plasma was collected 2 hours after the last administration and assayed for levels of the pain-related neuropeptide substance P (SP), calcitonin gene-related peptide (CGRP), tumor necrosis factor TNF-α, and interleukin (IL-β). The results are shown in Table 2.

[0093] Table 2

[0094] SP (pg / mL) CGRP (pg / mL) TNF-α (ng / mL) IL-β (ng / mL) control group 26.784±1.550 53.541±2.185 1.115±0.125 0.112±0.021 Model Group 13.217±0.994** 18.325±1.803** 2.258±0.183** 0.325±0.048** Example 1 <![CDATA[24.150±1.142 ## ]]> <![CDATA[42.450±2.017 ## ]]> <![CDATA[1.154±0.119 ## ]]> <![CDATA[0.145±0.024 ## ]]> Example 2 <![CDATA[22.152±1.040 ## ]]> <![CDATA[39.367±1.895 ## ]]> <![CDATA[1.172±0.121 ## ]]> <![CDATA[0.148±0.028 ## ]]> Example 3 <![CDATA[23.478±1.137 ## ]]> <![CDATA[40.291±1.942 ## ]]> <![CDATA[1.203±0.209 ## ]]> <![CDATA[0.151±0.031 ## ]]> Example 4 <![CDATA[22.561±1.084 ## ]]> <![CDATA[36.471±2.014* ## ]]> <![CDATA[1.235±0.150 ## ]]> <![CDATA[0.153±0.025 ## ]]> Example 5 <![CDATA[23.225±1.179 ## ]]> <![CDATA[38.425±2.106* ## ]]> <![CDATA[1.308±0.143 ## ]]> <![CDATA[0.149±0.028 ## ]]> Example 6 <![CDATA[23.561±1.144 ## ]]> <![CDATA[41.573±1.855 ## ]]> <![CDATA[1.195±0.129 ## ]]> <![CDATA[0.155±0.033 ## ]]> Example 7 <![CDATA[22.187±1.120 ## ]]> <![CDATA[40.922±1.884 ## ]]> <![CDATA[1.178±0.201 ## ]]> <![CDATA[0.152±0.031 ## ]]> Example 8 <![CDATA[21.179±1.133 # ]]> <![CDATA[42.018±2.110 ## ]]> <![CDATA[1.217±0.078 ## ]]> <![CDATA[0.146±0.029 ## ]]> Comparative Example 1 <![CDATA[17.171±1.105* #& ]]> <![CDATA[21.425±1.132** #&& ]]> <![CDATA[1.875±0.155 #&& ]]> <![CDATA[0.244±0.044 #&& ]]> Comparative Example 2 <![CDATA[17.045±1.119* #& ]]> <![CDATA[23.794±1.224** #&& ]]> <![CDATA[1.745±0.148 #&& ]]> <![CDATA[0.261±0.048 #&& <!-- 7 -->]]> Comparative Example 3 <![CDATA[15.432±1.152** && ]]> <![CDATA[26.877±1.138** #&& ]]> <![CDATA[1.533±0.133 #& ]]> <![CDATA[0.223±0.039 #& ]]> Comparative Example 4 <![CDATA[20.195±1.120 ## ]]> <![CDATA[40.315±2.150* ## ]]> <![CDATA[1.252±0.124 ## ]]> <![CDATA[0.155±0.022 ## ]]> Comparative Example 5 <![CDATA[21.524±1.108 ## ]]> <![CDATA[38.247±2.084* ## ]]> <![CDATA[1.270±0.117 ## ]]> <![CDATA[0.143±0.025 ## ]]>

[0095] Remark: * Compared with the control group, P < 0.05; ** Compared with the control group, P < 0.01; # Compared with the model group, P < 0.05; ## Compared with the model group, P < 0.01;& Compared with Example 1, P < 0.05; && Compared with Example 1, P < 0.01.

[0096] Related studies have shown that SP and CGRP play a positive role in accelerating bone formation and inhibiting bone resorption. As can be seen from the above table: compared with the control group, the levels of SP and CGRP in the plasma of mice in the model group decreased significantly, indicating that the modeling was successful. Compared with the model group, the levels of SP and CGRP in the mice in Examples 1-8 and Comparative Examples 4-5 were significantly improved (P < 0.01), indicating that the hot compress of the present invention can effectively repair tibial shaft fractures, but in Comparative Examples 4 and 5, under the same dosage of Chinese medicine components, the dosage of heating materials is higher, which is easy to affect the uniformity of the Chinese medicine components and thus affect the efficacy; compared with Example 1, the SP content of mice in Comparative Examples 1-3 had significant differences, and the CGRP content had extremely significant differences, indicating that the lack or replacement of Chinese medicine ingredients in the hot compress of the present invention, as well as changes in dosage, have a greater impact on the recovery of mice with fractures.

[0097] In addition, inflammatory factors IL-1β and TNF-α are closely related to cartilage damage, and cartilage damage can lead to increased levels of TNF-α and IL-1β. As can be seen from the above table, compared with the control group, the levels of TNF-α and IL-1β in the plasma of the model group mice were significantly increased, indicating that the modeling was successful. Compared with the model group, the levels of TNF-α and IL-1β in the mice in Example 1-8 groups were significantly decreased (P < 0.01), indicating that the hot compress of the present invention can effectively repair cartilage damage; compared with Example 1, the levels of TNF-α and IL-1β in the mice in the comparative example 1-2 groups were significantly different (P < 0.01), indicating that the Chinese herbal ingredients in the hot compress have a significant effect on the repair of cartilage damage; the levels of TNF-α and IL-1β in the mice in the comparative example 3 group were also significantly different (P < 0.05), indicating that the amount of Chinese herbal ingredients also has a certain degree of effect on cartilage damage. The present invention fully exerts the effect of each component by regulating the composition and dosage of the Chinese herbal ingredients in the hot compress.

[0098] 3. Observation of clinical efficacy in clinical volunteers with osteoarthritis

[0099] Two hundred clinical patients aged 35-65 were selected as volunteers. X-rays showed varying degrees of knee osteoarthritis, cervical disc herniation, lumbar disc herniation, and osteoporosis. They were divided into four groups based on their symptoms. Each group was then randomly divided into two groups: a control group and a treatment group. The groups were comparable in age, gender, and disease severity.

[0100] Treatment method: The control group applied Dai Wenjiu ointment to the painful area; the experimental group applied the Chinese medicine hot compress patch prepared in Example 1 of the present invention to the painful area; the application was applied once a day for 6 hours each time for 5 consecutive days.

[0101] Efficacy criteria: Based on the efficacy evaluation criteria in the "Guiding Principles for Clinical Research of New Traditional Chinese Medicines" and the efficacy criteria for TCM disease diagnosis and syndrome diagnosis, clinical efficacy was categorized into four levels: clinical cure, marked effect, effective, and ineffective. Changes in joint pain: Scores were 0, 1, 2, and 3 for each level (no change, relief, significantly relieved, and disappeared, respectively). Changes in joint swelling: Scores were 0, 1, and 2 for each level (no change, improvement, and disappearance, respectively). Changes in joint motion: Scores were 0, 1, and 2 for each level (no change, improvement, and normal, respectively). Changes in walking function: Scores were 0, 1, 2, and 3 for each level (no change, improvement, significantly improved, and normal, respectively).

[0102] The sum of the scores of the four observation indicators is 0.1, 2.5, 6.8 and 9.10, which represent ineffectiveness, effectiveness, marked effectiveness and clinical cure respectively. Total effective rate = (number of cured patients + number of marked effectiveness + number of effective patients) / total number of patients × 100%

[0103] From the above results, it can be seen that the composition of the present invention has a high therapeutic efficacy for cervical spondylosis, lumbar disc herniation, rheumatoid arthritis, osteoporosis and other musculoskeletal diseases, has excellent therapeutic effects and strong universality.

[0104] Finally, it should be noted that the above content is only used to illustrate the technical solution of the present invention, rather than to limit the scope of protection of the present invention. Simple modifications or equivalent substitutions of the technical solution of the present invention by ordinary technicians in this field do not deviate from the essence and scope of the technical solution of the present invention.

Claims

1. A Chinese medicine composition for promoting blood circulation and dispelling cold, characterized in that: The invention is prepared from the following raw materials in parts by weight: 5-15 parts of Bauhinia bark, 1-5 parts of Periploca odorata, 1-8 parts of Radix Trichosanthis, 1-6 parts of Red Peony Root, 0.5-5 parts of Notopterygium wilfordii, 1-5 parts of Angelica dahurica, 0.1-4 parts of Spina Gleditsiae, 5-10 parts of Vitex negundo, 0.5-5 parts of Rhizoma Chuanxiong, 0.2-1.2 parts of Forsythia suspensa, 0.5-4 parts of Chaenomeles sinensis, 0.2-0.8 parts of Licorice, 1-4 parts of Gentiana macrophylla, 0.5-1.5 parts of Angelica dahurica, 1.2-3 parts of Angelica sinensis, 1.5-2.5 parts of Saposhnikovia divaricata, 1-3 parts of Curcuma longa, 1-3 parts of Clematis chinensis, 0.5-2 parts of Gallnut, 0.5-5 parts of Salvia miltiorrhiza, 0.5-5 parts of Achyranthes bidentata and 0.1-1 parts of Scolopendra subspinipes.

2. The Chinese medicine composition according to claim 1, characterized in that The invention is prepared from the following raw materials in parts by weight: 6-10 parts of Bauhinia bark, 1-3 parts of Periploca odorata bark, 2-6 parts of Radix Trichosanthis, 1-3 parts of Red Peony Root, 1.5-2.5 parts of Notopterygium wilfordii, 1.5-2.5 parts of Angelica dahurica, 0.5-2 parts of Spinach Spinach, 7-9 parts of Vitex negundo, 1-3 parts of Ligusticum chuanxiong, 0.5-1 parts of Forsythia suspensa, 1-3 parts of Papaya, 0.4-0.6 parts of Licorice, 1-3 parts of Gentiana macrophylla, 0.8-1.2 parts of Angelica dahurica, 1.6-2.4 parts of Angelica sinensis, 1.8-2.2 parts of Saposhnikovia divaricata, 1.5-2.5 parts of Curcuma longa, 1.5-2.5 parts of Clematis chinensis, 0.8-1.2 parts of Gallnut, 1-3 parts of Salvia miltiorrhiza, 1-3 parts of Achyranthes bidentata and 0.3-0.8 parts of Scolopendra subspinipes.

3. The Chinese medicine composition according to claim 2, characterized in that The invention is prepared from the following raw materials in parts by weight: 8 parts of Bauhinia bark, 2 parts of Periploca odorata bark, 4 parts of Radix Trichosanthis, 2 parts of Red Peony Root, 2 parts of Notopterygium wilfordii, 2 parts of Angelica dahurica, 1 part of Gleditsia sinensis spinosa, 8 parts of Vitex negundo fruit, 2 parts of Ligusticum chuanxiong, 1 part of Forsythia suspensa, 2 parts of Chaenomeles sinensis, 0.5 part of Licorice root, 2 parts of Gentiana macrophylla, 1 part of Angelica dahurica, 2 parts of Angelica sinensis, 2 parts of Saposhnikovia divaricata, 2 parts of Curcuma longa, 2 parts of Clematidis root, 1 part of Gallnut, 2 parts of Salvia miltiorrhiza, 2 parts of Achyranthes bidentata and 0.5 part of Scolopendra subspinipes.

4. The Chinese medicine composition according to claim 1, characterized in that The mass ratio of the bark of Cercis chinensis, the fruit of Nelumbo nucifera and the salvia miltiorrhiza is 10-15:5-10:1-5; the mass ratio of the Notopterygium wilfordii and the Angelica dahurica is 1:1-1.

5.

5. Use of the Chinese medicine composition according to any one of claims 1 to 4 in preparing a medicine for treating musculoskeletal diseases, characterized in that: The bone and muscle disease is any one of cervical spondylosis, lumbar spondylosis, rheumatoid arthritis and osteoporosis; and the medicine is an external hot compress.

6. A Chinese medicine hot compress patch, characterized in that: The invention comprises the traditional Chinese medicine composition according to any one of claims 1 to 4 and a heating material.

7. The Chinese medicine hot compress patch according to claim 6, characterized in that: The heating material includes at least two of iron powder, activated carbon, vermiculite, panthenium and industrial salt.

8. The method for preparing the Chinese medicine hot compress according to claim 6 or 7, characterized in that: The following steps are involved: (1) Take Bauhinia bark, Perennial Herb, Radix Trichosanthis, Red Peony Root, Notopterygium wilfordii, Angelica dahurica, Gleditsia sinensis, Vitex negundo, Rhizoma Chuanxiong, Forsythia suspensa, Papaya, Licorice, Gentiana macrophylla, Angelica dahurica, Angelica sinensis, Saposhnikovia divaricata, Curcuma longa, Clematis chinensis, Gallnut, Salvia miltiorrhiza, Achyranthes bidentata and Scolopendra subspinipes, grind and sieve to obtain raw material powder; (2) adding the raw medicinal powder to water for grinding and extraction to obtain a Chinese medicine composition; (3) Mix the Chinese medicine composition with the heating material to obtain the product.

9. The preparation method according to claim 8, characterized in that In step (2), the mass volume ratio of the raw medicinal powder to water is 1:1-5 g / mL; the mass ratio of the traditional Chinese medicine composition to the heating material is 1:0.2-0.5.

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